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You searched for subject:(functional selectivity). Showing records 1 – 30 of 32 total matches.

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Vanderbilt University

1. Yin, Shen. Allosteric modulation of metabotropic glutamate receptors.

Degree: PhD, Pharmacology, 2013, Vanderbilt University

 Metabotropic glutamate receptors (mGlus) are a group of Family C Seven Transmembrane Spanning Receptors that play important roles in modulating signaling transduction, particularly within the… (more)

Subjects/Keywords: heterodimerization; functional selectivity; pharmacology; allosteric modulators; mGlu

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APA (6th Edition):

Yin, S. (2013). Allosteric modulation of metabotropic glutamate receptors. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://etd.library.vanderbilt.edu//available/etd-11262013-230503/ ;

Chicago Manual of Style (16th Edition):

Yin, Shen. “Allosteric modulation of metabotropic glutamate receptors.” 2013. Doctoral Dissertation, Vanderbilt University. Accessed November 12, 2019. http://etd.library.vanderbilt.edu//available/etd-11262013-230503/ ;.

MLA Handbook (7th Edition):

Yin, Shen. “Allosteric modulation of metabotropic glutamate receptors.” 2013. Web. 12 Nov 2019.

Vancouver:

Yin S. Allosteric modulation of metabotropic glutamate receptors. [Internet] [Doctoral dissertation]. Vanderbilt University; 2013. [cited 2019 Nov 12]. Available from: http://etd.library.vanderbilt.edu//available/etd-11262013-230503/ ;.

Council of Science Editors:

Yin S. Allosteric modulation of metabotropic glutamate receptors. [Doctoral Dissertation]. Vanderbilt University; 2013. Available from: http://etd.library.vanderbilt.edu//available/etd-11262013-230503/ ;


University of Kansas

2. Johnson, Stephanie. Design and Synthesis of Functionally Selective Kappa Opioid Receptor Ligands.

Degree: MS, Medicinal Chemistry, 2017, University of Kansas

 The ability of ligands to differentially regulate the activity of signaling pathways coupled to a receptor potentially enables researchers to optimize therapeutically relevant efficacies, while… (more)

Subjects/Keywords: Pharmaceutical sciences; Organic chemistry; Chemistry; functional; kappa; opioid; selectivity; U50; 488

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APA (6th Edition):

Johnson, S. (2017). Design and Synthesis of Functionally Selective Kappa Opioid Receptor Ligands. (Masters Thesis). University of Kansas. Retrieved from http://hdl.handle.net/1808/26154

Chicago Manual of Style (16th Edition):

Johnson, Stephanie. “Design and Synthesis of Functionally Selective Kappa Opioid Receptor Ligands.” 2017. Masters Thesis, University of Kansas. Accessed November 12, 2019. http://hdl.handle.net/1808/26154.

MLA Handbook (7th Edition):

Johnson, Stephanie. “Design and Synthesis of Functionally Selective Kappa Opioid Receptor Ligands.” 2017. Web. 12 Nov 2019.

Vancouver:

Johnson S. Design and Synthesis of Functionally Selective Kappa Opioid Receptor Ligands. [Internet] [Masters thesis]. University of Kansas; 2017. [cited 2019 Nov 12]. Available from: http://hdl.handle.net/1808/26154.

Council of Science Editors:

Johnson S. Design and Synthesis of Functionally Selective Kappa Opioid Receptor Ligands. [Masters Thesis]. University of Kansas; 2017. Available from: http://hdl.handle.net/1808/26154


Purdue University

3. Brust Fernandes, Tarsis. FUNCTIONAL SELECTIVITY DOWNSTREAM OF Gαi/o-COUPLED RECEPTORS.

Degree: PhD, Medicinal Chemistry and Molecular Pharmacology, 2015, Purdue University

 G protein-coupled receptors (GPCRs) are drug targets that often activate multiple signaling pathways. The multiple GPCR responses provide opportunities for biased or functionally selective ligands… (more)

Subjects/Keywords: adenylyl cyclase; beta-arrestin; biased signaling; functional selectivity; GPCR; G protein

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APA (6th Edition):

Brust Fernandes, T. (2015). FUNCTIONAL SELECTIVITY DOWNSTREAM OF Gαi/o-COUPLED RECEPTORS. (Doctoral Dissertation). Purdue University. Retrieved from https://docs.lib.purdue.edu/open_access_dissertations/1448

Chicago Manual of Style (16th Edition):

Brust Fernandes, Tarsis. “FUNCTIONAL SELECTIVITY DOWNSTREAM OF Gαi/o-COUPLED RECEPTORS.” 2015. Doctoral Dissertation, Purdue University. Accessed November 12, 2019. https://docs.lib.purdue.edu/open_access_dissertations/1448.

MLA Handbook (7th Edition):

Brust Fernandes, Tarsis. “FUNCTIONAL SELECTIVITY DOWNSTREAM OF Gαi/o-COUPLED RECEPTORS.” 2015. Web. 12 Nov 2019.

Vancouver:

Brust Fernandes T. FUNCTIONAL SELECTIVITY DOWNSTREAM OF Gαi/o-COUPLED RECEPTORS. [Internet] [Doctoral dissertation]. Purdue University; 2015. [cited 2019 Nov 12]. Available from: https://docs.lib.purdue.edu/open_access_dissertations/1448.

Council of Science Editors:

Brust Fernandes T. FUNCTIONAL SELECTIVITY DOWNSTREAM OF Gαi/o-COUPLED RECEPTORS. [Doctoral Dissertation]. Purdue University; 2015. Available from: https://docs.lib.purdue.edu/open_access_dissertations/1448


The Ohio State University

4. Schmid, Cullen L. Differential regulation of serotonin 2A receptor responsiveness by agonist-directed interactions with beta-arrestin2.

Degree: PhD, Neuroscience Graduate Studies Program, 2011, The Ohio State University

 The G protein-coupled, serotonin 2A (5-HT2A) receptor is a major drug target for the treatment of a number of mental health disorders, including schizophrenia, anxiety… (more)

Subjects/Keywords: Neurosciences; Pharmacology; G protein-coupled receptor; Serotonin 2A receptor; beta-arrestin2; hallucinogens; functional selectivity

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APA (6th Edition):

Schmid, C. L. (2011). Differential regulation of serotonin 2A receptor responsiveness by agonist-directed interactions with beta-arrestin2. (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1300287547

Chicago Manual of Style (16th Edition):

Schmid, Cullen L. “Differential regulation of serotonin 2A receptor responsiveness by agonist-directed interactions with beta-arrestin2.” 2011. Doctoral Dissertation, The Ohio State University. Accessed November 12, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1300287547.

MLA Handbook (7th Edition):

Schmid, Cullen L. “Differential regulation of serotonin 2A receptor responsiveness by agonist-directed interactions with beta-arrestin2.” 2011. Web. 12 Nov 2019.

Vancouver:

Schmid CL. Differential regulation of serotonin 2A receptor responsiveness by agonist-directed interactions with beta-arrestin2. [Internet] [Doctoral dissertation]. The Ohio State University; 2011. [cited 2019 Nov 12]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1300287547.

Council of Science Editors:

Schmid CL. Differential regulation of serotonin 2A receptor responsiveness by agonist-directed interactions with beta-arrestin2. [Doctoral Dissertation]. The Ohio State University; 2011. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1300287547


UCLA

5. Yu, Peiyuan. Computational Studies on the Reactivity, Selectivity and Molecular Dynamics of Cycloaddition Reactions.

Degree: Chemistry, 2017, UCLA

 The first part of this dissertation describes computational studies of higher-order cycloadditions with a focus on elucidating the origins of periselectivity. These reactions involve ambimodal… (more)

Subjects/Keywords: Chemistry; Organic chemistry; Cycloaddition; Density Functional Theory; Diels–Alder; Molecular Dynamics; Reactivity; Selectivity

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APA (6th Edition):

Yu, P. (2017). Computational Studies on the Reactivity, Selectivity and Molecular Dynamics of Cycloaddition Reactions. (Thesis). UCLA. Retrieved from http://www.escholarship.org/uc/item/1jk894mq

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Yu, Peiyuan. “Computational Studies on the Reactivity, Selectivity and Molecular Dynamics of Cycloaddition Reactions.” 2017. Thesis, UCLA. Accessed November 12, 2019. http://www.escholarship.org/uc/item/1jk894mq.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Yu, Peiyuan. “Computational Studies on the Reactivity, Selectivity and Molecular Dynamics of Cycloaddition Reactions.” 2017. Web. 12 Nov 2019.

Vancouver:

Yu P. Computational Studies on the Reactivity, Selectivity and Molecular Dynamics of Cycloaddition Reactions. [Internet] [Thesis]. UCLA; 2017. [cited 2019 Nov 12]. Available from: http://www.escholarship.org/uc/item/1jk894mq.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Yu P. Computational Studies on the Reactivity, Selectivity and Molecular Dynamics of Cycloaddition Reactions. [Thesis]. UCLA; 2017. Available from: http://www.escholarship.org/uc/item/1jk894mq

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

6. Rahmeh, Rita. Etude des bases structurales de l’efficacité et de la sélectivité fonctionnelle des récepteurs couplés aux protéines G : cas du récepteur V2 de la vasopressine : Study of structural bases of efficacy and functional selectivity of G protein-coupled receptors : a case study with vasopressin V2 receptor.

Degree: Docteur es, Biologie Santé, 2010, Université Montpellier I

 Les récepteurs couplés aux protéines G (RCPG) représentent la plus grande famille de protéines membranaires. Ils sont activés par une grande variété d'hormones, de neurotransmetteurs,… (more)

Subjects/Keywords: Rcpg; Arginine-vasopressine; Efficacité; Sélectivité fonctionnelle; Gpcr; Arginine-vasopressin; Efficacy; Functional selectivity

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APA (6th Edition):

Rahmeh, R. (2010). Etude des bases structurales de l’efficacité et de la sélectivité fonctionnelle des récepteurs couplés aux protéines G : cas du récepteur V2 de la vasopressine : Study of structural bases of efficacy and functional selectivity of G protein-coupled receptors : a case study with vasopressin V2 receptor. (Doctoral Dissertation). Université Montpellier I. Retrieved from http://www.theses.fr/2010MON1T033

Chicago Manual of Style (16th Edition):

Rahmeh, Rita. “Etude des bases structurales de l’efficacité et de la sélectivité fonctionnelle des récepteurs couplés aux protéines G : cas du récepteur V2 de la vasopressine : Study of structural bases of efficacy and functional selectivity of G protein-coupled receptors : a case study with vasopressin V2 receptor.” 2010. Doctoral Dissertation, Université Montpellier I. Accessed November 12, 2019. http://www.theses.fr/2010MON1T033.

MLA Handbook (7th Edition):

Rahmeh, Rita. “Etude des bases structurales de l’efficacité et de la sélectivité fonctionnelle des récepteurs couplés aux protéines G : cas du récepteur V2 de la vasopressine : Study of structural bases of efficacy and functional selectivity of G protein-coupled receptors : a case study with vasopressin V2 receptor.” 2010. Web. 12 Nov 2019.

Vancouver:

Rahmeh R. Etude des bases structurales de l’efficacité et de la sélectivité fonctionnelle des récepteurs couplés aux protéines G : cas du récepteur V2 de la vasopressine : Study of structural bases of efficacy and functional selectivity of G protein-coupled receptors : a case study with vasopressin V2 receptor. [Internet] [Doctoral dissertation]. Université Montpellier I; 2010. [cited 2019 Nov 12]. Available from: http://www.theses.fr/2010MON1T033.

Council of Science Editors:

Rahmeh R. Etude des bases structurales de l’efficacité et de la sélectivité fonctionnelle des récepteurs couplés aux protéines G : cas du récepteur V2 de la vasopressine : Study of structural bases of efficacy and functional selectivity of G protein-coupled receptors : a case study with vasopressin V2 receptor. [Doctoral Dissertation]. Université Montpellier I; 2010. Available from: http://www.theses.fr/2010MON1T033


Freie Universität Berlin

7. Dinter, Juliane. Functional selectivity of G-Protein coupled receptors with a role in energy homeostasis.

Degree: 2015, Freie Universität Berlin

 G-protein coupled receptors (GPCRs) are involved in the control of all basic cellular and physiological functions such as metabolism, cell differentiation and growth. The characteristics… (more)

Subjects/Keywords: GPCR; functional selectivity; energy homeostasis; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA (6th Edition):

Dinter, J. (2015). Functional selectivity of G-Protein coupled receptors with a role in energy homeostasis. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-10264

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Dinter, Juliane. “Functional selectivity of G-Protein coupled receptors with a role in energy homeostasis.” 2015. Thesis, Freie Universität Berlin. Accessed November 12, 2019. http://dx.doi.org/10.17169/refubium-10264.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Dinter, Juliane. “Functional selectivity of G-Protein coupled receptors with a role in energy homeostasis.” 2015. Web. 12 Nov 2019.

Vancouver:

Dinter J. Functional selectivity of G-Protein coupled receptors with a role in energy homeostasis. [Internet] [Thesis]. Freie Universität Berlin; 2015. [cited 2019 Nov 12]. Available from: http://dx.doi.org/10.17169/refubium-10264.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Dinter J. Functional selectivity of G-Protein coupled receptors with a role in energy homeostasis. [Thesis]. Freie Universität Berlin; 2015. Available from: http://dx.doi.org/10.17169/refubium-10264

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


University of Arizona

8. Olson, Keith Mathew. Atypical Opioid Interactions – Development of Selective Mu-Delta Heterodimer Antagonists, Clinical Opioids at Non-Mu Pain Targets and Endogenous Biased Signaling .

Degree: 2017, University of Arizona

 Most clinical opioids produce analgesia through the Mu Opioid Receptor (MOR) providing the only effective treatment for chronic pain patients. These studies explore three pre-clinical… (more)

Subjects/Keywords: Bivalent; Delta Opioid Receptor; Functional Selectivity; MDOR Heterodimer; Mu Opioid Receptor; Opioid Signaling

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APA (6th Edition):

Olson, K. M. (2017). Atypical Opioid Interactions – Development of Selective Mu-Delta Heterodimer Antagonists, Clinical Opioids at Non-Mu Pain Targets and Endogenous Biased Signaling . (Doctoral Dissertation). University of Arizona. Retrieved from http://hdl.handle.net/10150/626669

Chicago Manual of Style (16th Edition):

Olson, Keith Mathew. “Atypical Opioid Interactions – Development of Selective Mu-Delta Heterodimer Antagonists, Clinical Opioids at Non-Mu Pain Targets and Endogenous Biased Signaling .” 2017. Doctoral Dissertation, University of Arizona. Accessed November 12, 2019. http://hdl.handle.net/10150/626669.

MLA Handbook (7th Edition):

Olson, Keith Mathew. “Atypical Opioid Interactions – Development of Selective Mu-Delta Heterodimer Antagonists, Clinical Opioids at Non-Mu Pain Targets and Endogenous Biased Signaling .” 2017. Web. 12 Nov 2019.

Vancouver:

Olson KM. Atypical Opioid Interactions – Development of Selective Mu-Delta Heterodimer Antagonists, Clinical Opioids at Non-Mu Pain Targets and Endogenous Biased Signaling . [Internet] [Doctoral dissertation]. University of Arizona; 2017. [cited 2019 Nov 12]. Available from: http://hdl.handle.net/10150/626669.

Council of Science Editors:

Olson KM. Atypical Opioid Interactions – Development of Selective Mu-Delta Heterodimer Antagonists, Clinical Opioids at Non-Mu Pain Targets and Endogenous Biased Signaling . [Doctoral Dissertation]. University of Arizona; 2017. Available from: http://hdl.handle.net/10150/626669


Université de Montréal

9. Charfi, Iness. Étude du trafic du récepteur delta-opiacé suite à sa stimulation par différents agonistes .

Degree: 2012, Université de Montréal

 Les opiacés figurent parmi les analgésiques les plus puissants pour le traitement des douleurs sévères. Les agonistes du DOR (récepteur delta opiacé) induisent moins d'effets… (more)

Subjects/Keywords: Récepteur delta opiacé; Signalisation; Internalisation; Recyclage; Analgésie; Tolérance; Sélectivité fonctionnelle; Delta opioid receptor; Signaling; Internalization; Recycling; Analgesia; Tolerance; Functional selectivity

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APA (6th Edition):

Charfi, I. (2012). Étude du trafic du récepteur delta-opiacé suite à sa stimulation par différents agonistes . (Thesis). Université de Montréal. Retrieved from http://hdl.handle.net/1866/8899

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Charfi, Iness. “Étude du trafic du récepteur delta-opiacé suite à sa stimulation par différents agonistes .” 2012. Thesis, Université de Montréal. Accessed November 12, 2019. http://hdl.handle.net/1866/8899.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Charfi, Iness. “Étude du trafic du récepteur delta-opiacé suite à sa stimulation par différents agonistes .” 2012. Web. 12 Nov 2019.

Vancouver:

Charfi I. Étude du trafic du récepteur delta-opiacé suite à sa stimulation par différents agonistes . [Internet] [Thesis]. Université de Montréal; 2012. [cited 2019 Nov 12]. Available from: http://hdl.handle.net/1866/8899.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Charfi I. Étude du trafic du récepteur delta-opiacé suite à sa stimulation par différents agonistes . [Thesis]. Université de Montréal; 2012. Available from: http://hdl.handle.net/1866/8899

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Université de Montréal

10. Richard-Lalonde, Mélissa. Développement d'un biosenseur BRET permettant le criblage de drogues qui causent l'activation de canaux Kir3 via les récepteurs couplés aux protéines G .

Degree: 2011, Université de Montréal

 Les récepteurs couplés aux protéines G forment des complexes multimériques comprenant protéines G et effecteurs. Nous cherchons à caractériser de tels complexes comprenant les récepteurs… (more)

Subjects/Keywords: complexes multimériques; récepteurs opioïdes delta; sélectivité fonctionnelle; HEK293; conformations multiples; multimeric complexes; functional selectivity; delta opioid receptors; HEK293; multiple conformations

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APA (6th Edition):

Richard-Lalonde, M. (2011). Développement d'un biosenseur BRET permettant le criblage de drogues qui causent l'activation de canaux Kir3 via les récepteurs couplés aux protéines G . (Thesis). Université de Montréal. Retrieved from http://hdl.handle.net/1866/6964

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Richard-Lalonde, Mélissa. “Développement d'un biosenseur BRET permettant le criblage de drogues qui causent l'activation de canaux Kir3 via les récepteurs couplés aux protéines G .” 2011. Thesis, Université de Montréal. Accessed November 12, 2019. http://hdl.handle.net/1866/6964.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Richard-Lalonde, Mélissa. “Développement d'un biosenseur BRET permettant le criblage de drogues qui causent l'activation de canaux Kir3 via les récepteurs couplés aux protéines G .” 2011. Web. 12 Nov 2019.

Vancouver:

Richard-Lalonde M. Développement d'un biosenseur BRET permettant le criblage de drogues qui causent l'activation de canaux Kir3 via les récepteurs couplés aux protéines G . [Internet] [Thesis]. Université de Montréal; 2011. [cited 2019 Nov 12]. Available from: http://hdl.handle.net/1866/6964.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Richard-Lalonde M. Développement d'un biosenseur BRET permettant le criblage de drogues qui causent l'activation de canaux Kir3 via les récepteurs couplés aux protéines G . [Thesis]. Université de Montréal; 2011. Available from: http://hdl.handle.net/1866/6964

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


University of Guelph

11. Silenieks, Leonardo. The Effect of 5-HT2C Receptor Activation on Nausea-Induced Behaviour in Rats .

Degree: 2014, University of Guelph

 The present study aimed at investigating the role of the 5-HT2C receptor in nausea using different models of nausea-induced behaviour in rats. Two chemically distinct… (more)

Subjects/Keywords: Neuroscience; Nausea; Serotonin; 5-HT2C; Lorcaserin; CP-809101; Pharmacology; Behavioural Neuroscience; Obesity; Conditioned Gaping; Taste Reactivity; Functional Selectivity

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APA (6th Edition):

Silenieks, L. (2014). The Effect of 5-HT2C Receptor Activation on Nausea-Induced Behaviour in Rats . (Thesis). University of Guelph. Retrieved from https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8306

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Silenieks, Leonardo. “The Effect of 5-HT2C Receptor Activation on Nausea-Induced Behaviour in Rats .” 2014. Thesis, University of Guelph. Accessed November 12, 2019. https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8306.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Silenieks, Leonardo. “The Effect of 5-HT2C Receptor Activation on Nausea-Induced Behaviour in Rats .” 2014. Web. 12 Nov 2019.

Vancouver:

Silenieks L. The Effect of 5-HT2C Receptor Activation on Nausea-Induced Behaviour in Rats . [Internet] [Thesis]. University of Guelph; 2014. [cited 2019 Nov 12]. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8306.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Silenieks L. The Effect of 5-HT2C Receptor Activation on Nausea-Induced Behaviour in Rats . [Thesis]. University of Guelph; 2014. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8306

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

12. Cabana, Jérôme. Étude des déterminants structuraux de l'activation des voies de signalisation de la protéine G[indice inférieur q/11] et des β-arrestines par le récepteur de type 1 à l'angiotensine II.

Degree: PhD, Pharmacologie, 2015, Université de Sherbrooke

 Résumé : La signalisation biaisée représente la capacité des récepteurs couplés aux protéines G (RCPG) d'engager des voies de signalisation distinctes avec des efficacités variables… (more)

Subjects/Keywords: RCPG; GPCR; Récepteur AT1; Mécanisme d'activation; Sélectivité fonctionnelle; Signalisation biaisée; Angiotensine II; Dynamique moléculaire; AT1 receptor; Activation mechanism; Angiotensin II; Biased signaling; Functional selectivity; Molecular dynamics

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APA (6th Edition):

Cabana, J. (2015). Étude des déterminants structuraux de l'activation des voies de signalisation de la protéine G[indice inférieur q/11] et des β-arrestines par le récepteur de type 1 à l'angiotensine II. (Doctoral Dissertation). Université de Sherbrooke. Retrieved from http://www.collectionscanada.gc.ca/obj/thesescanada/vol2/QSHERU/TC-QSHERU-11143_7706.pdf ; http://savoirs.usherbrooke.ca/bitstream/11143/7706/4/Cabana_Jerome_PhD_2015.pdf

Chicago Manual of Style (16th Edition):

Cabana, Jérôme. “Étude des déterminants structuraux de l'activation des voies de signalisation de la protéine G[indice inférieur q/11] et des β-arrestines par le récepteur de type 1 à l'angiotensine II.” 2015. Doctoral Dissertation, Université de Sherbrooke. Accessed November 12, 2019. http://www.collectionscanada.gc.ca/obj/thesescanada/vol2/QSHERU/TC-QSHERU-11143_7706.pdf ; http://savoirs.usherbrooke.ca/bitstream/11143/7706/4/Cabana_Jerome_PhD_2015.pdf.

MLA Handbook (7th Edition):

Cabana, Jérôme. “Étude des déterminants structuraux de l'activation des voies de signalisation de la protéine G[indice inférieur q/11] et des β-arrestines par le récepteur de type 1 à l'angiotensine II.” 2015. Web. 12 Nov 2019.

Vancouver:

Cabana J. Étude des déterminants structuraux de l'activation des voies de signalisation de la protéine G[indice inférieur q/11] et des β-arrestines par le récepteur de type 1 à l'angiotensine II. [Internet] [Doctoral dissertation]. Université de Sherbrooke; 2015. [cited 2019 Nov 12]. Available from: http://www.collectionscanada.gc.ca/obj/thesescanada/vol2/QSHERU/TC-QSHERU-11143_7706.pdf ; http://savoirs.usherbrooke.ca/bitstream/11143/7706/4/Cabana_Jerome_PhD_2015.pdf.

Council of Science Editors:

Cabana J. Étude des déterminants structuraux de l'activation des voies de signalisation de la protéine G[indice inférieur q/11] et des β-arrestines par le récepteur de type 1 à l'angiotensine II. [Doctoral Dissertation]. Université de Sherbrooke; 2015. Available from: http://www.collectionscanada.gc.ca/obj/thesescanada/vol2/QSHERU/TC-QSHERU-11143_7706.pdf ; http://savoirs.usherbrooke.ca/bitstream/11143/7706/4/Cabana_Jerome_PhD_2015.pdf


Université de Montréal

13. Trottier, Giacomo. The biasing of the 5-HT4 receptor as an antidepressant target .

Degree: 2017, Université de Montréal

 La dépression majeure peut être très dommageable pour le 8% des Nord-Américains qui en souffriront au moins une fois durant leur vie. Les traitements actuels… (more)

Subjects/Keywords: 5-HT; RS67333; BRET; AD; Antidepressant; pCREB; CREB; Anhedonia; Zacopride; Prucalopride; ML10302; 5-HT4; Functional Selectivity; anhédonie; GPCR; récepteur 5-HT4; 5-HT4 Receptor; Sélectivité Fonctionnelle

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Trottier, G. (2017). The biasing of the 5-HT4 receptor as an antidepressant target . (Thesis). Université de Montréal. Retrieved from http://hdl.handle.net/1866/18903

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Trottier, Giacomo. “The biasing of the 5-HT4 receptor as an antidepressant target .” 2017. Thesis, Université de Montréal. Accessed November 12, 2019. http://hdl.handle.net/1866/18903.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Trottier, Giacomo. “The biasing of the 5-HT4 receptor as an antidepressant target .” 2017. Web. 12 Nov 2019.

Vancouver:

Trottier G. The biasing of the 5-HT4 receptor as an antidepressant target . [Internet] [Thesis]. Université de Montréal; 2017. [cited 2019 Nov 12]. Available from: http://hdl.handle.net/1866/18903.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Trottier G. The biasing of the 5-HT4 receptor as an antidepressant target . [Thesis]. Université de Montréal; 2017. Available from: http://hdl.handle.net/1866/18903

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Université de Sherbrooke

14. Cabana, Jérôme. Étude des déterminants structuraux de l'activation des voies de signalisation de la protéine G[indice inférieur q/11] et des β-arrestines par le récepteur de type 1 à l'angiotensine II .

Degree: 2015, Université de Sherbrooke

 Résumé : La signalisation biaisée représente la capacité des récepteurs couplés aux protéines G (RCPG) d'engager des voies de signalisation distinctes avec des efficacités variables… (more)

Subjects/Keywords: RCPG; GPCR; Récepteur AT1; Mécanisme d'activation; Sélectivité fonctionnelle; Signalisation biaisée; Angiotensine II; Dynamique moléculaire; AT1 receptor; Activation mechanism; Angiotensin II; Biased signaling; Functional selectivity; Molecular dynamics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Cabana, J. (2015). Étude des déterminants structuraux de l'activation des voies de signalisation de la protéine G[indice inférieur q/11] et des β-arrestines par le récepteur de type 1 à l'angiotensine II . (Doctoral Dissertation). Université de Sherbrooke. Retrieved from http://hdl.handle.net/11143/7706

Chicago Manual of Style (16th Edition):

Cabana, Jérôme. “Étude des déterminants structuraux de l'activation des voies de signalisation de la protéine G[indice inférieur q/11] et des β-arrestines par le récepteur de type 1 à l'angiotensine II .” 2015. Doctoral Dissertation, Université de Sherbrooke. Accessed November 12, 2019. http://hdl.handle.net/11143/7706.

MLA Handbook (7th Edition):

Cabana, Jérôme. “Étude des déterminants structuraux de l'activation des voies de signalisation de la protéine G[indice inférieur q/11] et des β-arrestines par le récepteur de type 1 à l'angiotensine II .” 2015. Web. 12 Nov 2019.

Vancouver:

Cabana J. Étude des déterminants structuraux de l'activation des voies de signalisation de la protéine G[indice inférieur q/11] et des β-arrestines par le récepteur de type 1 à l'angiotensine II . [Internet] [Doctoral dissertation]. Université de Sherbrooke; 2015. [cited 2019 Nov 12]. Available from: http://hdl.handle.net/11143/7706.

Council of Science Editors:

Cabana J. Étude des déterminants structuraux de l'activation des voies de signalisation de la protéine G[indice inférieur q/11] et des β-arrestines par le récepteur de type 1 à l'angiotensine II . [Doctoral Dissertation]. Université de Sherbrooke; 2015. Available from: http://hdl.handle.net/11143/7706

15. Nattino, Francesco. Ab initio molecular dynamics calculations on reactions of molecules with metal surfaces.

Degree: 2015, Theoretical Chemistry Group, Leiden Institute of Chemistry (LIC), Faculty of Science, Leiden University

 Reactions on metal surfaces are of scientific interest due to the tremendous relevance of heterogeneous catalysis. Single crystal surfaces under controlled physical conditions are generally… (more)

Subjects/Keywords: Ab-initio-molecular-dynamics; Density-functional-theory; Gas-surface dynamics; Surface-temperature effects; Mode specificity; Bond selectivity; Ab-initio-molecular-dynamics; Density-functional-theory; Gas-surface dynamics; Surface-temperature effects; Mode specificity; Bond selectivity

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Nattino, F. (2015). Ab initio molecular dynamics calculations on reactions of molecules with metal surfaces. (Doctoral Dissertation). Theoretical Chemistry Group, Leiden Institute of Chemistry (LIC), Faculty of Science, Leiden University. Retrieved from http://hdl.handle.net/1887/35980

Chicago Manual of Style (16th Edition):

Nattino, Francesco. “Ab initio molecular dynamics calculations on reactions of molecules with metal surfaces.” 2015. Doctoral Dissertation, Theoretical Chemistry Group, Leiden Institute of Chemistry (LIC), Faculty of Science, Leiden University. Accessed November 12, 2019. http://hdl.handle.net/1887/35980.

MLA Handbook (7th Edition):

Nattino, Francesco. “Ab initio molecular dynamics calculations on reactions of molecules with metal surfaces.” 2015. Web. 12 Nov 2019.

Vancouver:

Nattino F. Ab initio molecular dynamics calculations on reactions of molecules with metal surfaces. [Internet] [Doctoral dissertation]. Theoretical Chemistry Group, Leiden Institute of Chemistry (LIC), Faculty of Science, Leiden University; 2015. [cited 2019 Nov 12]. Available from: http://hdl.handle.net/1887/35980.

Council of Science Editors:

Nattino F. Ab initio molecular dynamics calculations on reactions of molecules with metal surfaces. [Doctoral Dissertation]. Theoretical Chemistry Group, Leiden Institute of Chemistry (LIC), Faculty of Science, Leiden University; 2015. Available from: http://hdl.handle.net/1887/35980


Université de Montréal

16. Lagréou, Alexandre. À la recherche de meilleurs traitements analgésiques : interactions entre le récepteur opioïde δ et ses différents agonistes .

Degree: 2017, Université de Montréal

 Les opioïdes restent encore à l’heure actuelle les composés pharmacologiques les plus efficaces pour traiter les différentes formes de douleurs, et donc fournir une analgésie… (more)

Subjects/Keywords: Récepteurs couplés aux protéines G; RCPG; Sélectivité fonctionnelle; Analgésie; Biais; Convulsions; Modèle opérationnel; G protein-coupled receptor; GPCR; Bioluminescence resonance energy transfer; BRET; Delta opioid receptor; Récepteur opioïde delta; DOP; Analgesia; Functional selectivity; Transfert d'énergie de bioluminescence par résonance; Biased agonism; Seizures; Operational model

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Lagréou, A. (2017). À la recherche de meilleurs traitements analgésiques : interactions entre le récepteur opioïde δ et ses différents agonistes . (Thesis). Université de Montréal. Retrieved from http://hdl.handle.net/1866/18900

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Lagréou, Alexandre. “À la recherche de meilleurs traitements analgésiques : interactions entre le récepteur opioïde δ et ses différents agonistes .” 2017. Thesis, Université de Montréal. Accessed November 12, 2019. http://hdl.handle.net/1866/18900.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Lagréou, Alexandre. “À la recherche de meilleurs traitements analgésiques : interactions entre le récepteur opioïde δ et ses différents agonistes .” 2017. Web. 12 Nov 2019.

Vancouver:

Lagréou A. À la recherche de meilleurs traitements analgésiques : interactions entre le récepteur opioïde δ et ses différents agonistes . [Internet] [Thesis]. Université de Montréal; 2017. [cited 2019 Nov 12]. Available from: http://hdl.handle.net/1866/18900.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lagréou A. À la recherche de meilleurs traitements analgésiques : interactions entre le récepteur opioïde δ et ses différents agonistes . [Thesis]. Université de Montréal; 2017. Available from: http://hdl.handle.net/1866/18900

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Université de Montréal

17. Audet, Nicolas. La sélectivité fonctionnelle des ligands du récepteur delta opiacé .

Degree: 2012, Université de Montréal

 Les récepteurs couplés aux protéines GRCPG sont une des plus grandes familles de récepteur membranaire codifié par le génome humain et certainement la plus grande… (more)

Subjects/Keywords: Récepteur couplé au protéine G; Opiacé; Tolérance; βarrestine; Signalisation; Régulation; Récepteur opiacé delta; Douleur; Sélectivité fonctionnelle; Recyclage; G protein coupled receptor; Opioid; Tolerance; βarrestin; Regulation; Delta opioid receptor; Pain; analgesic; Functional selectivity; Desensitization

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Audet, N. (2012). La sélectivité fonctionnelle des ligands du récepteur delta opiacé . (Thesis). Université de Montréal. Retrieved from http://hdl.handle.net/1866/7057

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Audet, Nicolas. “La sélectivité fonctionnelle des ligands du récepteur delta opiacé .” 2012. Thesis, Université de Montréal. Accessed November 12, 2019. http://hdl.handle.net/1866/7057.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Audet, Nicolas. “La sélectivité fonctionnelle des ligands du récepteur delta opiacé .” 2012. Web. 12 Nov 2019.

Vancouver:

Audet N. La sélectivité fonctionnelle des ligands du récepteur delta opiacé . [Internet] [Thesis]. Université de Montréal; 2012. [cited 2019 Nov 12]. Available from: http://hdl.handle.net/1866/7057.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Audet N. La sélectivité fonctionnelle des ligands du récepteur delta opiacé . [Thesis]. Université de Montréal; 2012. Available from: http://hdl.handle.net/1866/7057

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

18. Stallaert, Wayne. Use of cellular impedance to characterize ligand functional selectivity at G protein-coupled receptors .

Degree: 2014, Université de Montréal

 Les récepteurs couplés aux protéines G (RCPGs) représentent la plus grande famille de cibles thérapeutiques pour le traitement d’une panoplie de pathologies humaines. Bien que… (more)

Subjects/Keywords: Récepteurs couplés aux protéines G; Récepteur β2-adrénergique; Sélectivité fonctionnelle des ligands; Réseaux signalétique; Impédance cellulaire; Cardiomyocytes; Découverte de médicaments; G protein-coupled receptors; β2-adrenergic receptor; Ligand functional selectivity; Signalling networks; Cellular impedance

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Stallaert, W. (2014). Use of cellular impedance to characterize ligand functional selectivity at G protein-coupled receptors . (Thesis). Université de Montréal. Retrieved from http://hdl.handle.net/1866/11055

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Stallaert, Wayne. “Use of cellular impedance to characterize ligand functional selectivity at G protein-coupled receptors .” 2014. Thesis, Université de Montréal. Accessed November 12, 2019. http://hdl.handle.net/1866/11055.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Stallaert, Wayne. “Use of cellular impedance to characterize ligand functional selectivity at G protein-coupled receptors .” 2014. Web. 12 Nov 2019.

Vancouver:

Stallaert W. Use of cellular impedance to characterize ligand functional selectivity at G protein-coupled receptors . [Internet] [Thesis]. Université de Montréal; 2014. [cited 2019 Nov 12]. Available from: http://hdl.handle.net/1866/11055.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Stallaert W. Use of cellular impedance to characterize ligand functional selectivity at G protein-coupled receptors . [Thesis]. Université de Montréal; 2014. Available from: http://hdl.handle.net/1866/11055

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Université de Montréal

19. Leduc, Martin. Étude de la pharmacologie de ligands du récepteur EP4 de prostaglandine E2 .

Degree: 2010, Université de Montréal

 La prostaglandine E2 est une hormone lipidique produite abondamment dans le corps, incluant dans le rein où elle agit localement pour réguler les fonctions rénales.… (more)

Subjects/Keywords: PGE2; Récepteur couplé aux protéines G; sélectivité fonctionnelle; allostérie; insuffisance rénale aiguë; peptidomimétique; signalisation; transfert d’énergie de résonance de bioluminescence; BRET; Prostaglandin; EP4; G protein-coupled receptor; functional selectivity; allosteric; acute renal failure; peptidomimetic; signaling; GPCR

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Leduc, M. (2010). Étude de la pharmacologie de ligands du récepteur EP4 de prostaglandine E2 . (Thesis). Université de Montréal. Retrieved from http://hdl.handle.net/1866/4698

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Leduc, Martin. “Étude de la pharmacologie de ligands du récepteur EP4 de prostaglandine E2 .” 2010. Thesis, Université de Montréal. Accessed November 12, 2019. http://hdl.handle.net/1866/4698.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Leduc, Martin. “Étude de la pharmacologie de ligands du récepteur EP4 de prostaglandine E2 .” 2010. Web. 12 Nov 2019.

Vancouver:

Leduc M. Étude de la pharmacologie de ligands du récepteur EP4 de prostaglandine E2 . [Internet] [Thesis]. Université de Montréal; 2010. [cited 2019 Nov 12]. Available from: http://hdl.handle.net/1866/4698.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Leduc M. Étude de la pharmacologie de ligands du récepteur EP4 de prostaglandine E2 . [Thesis]. Université de Montréal; 2010. Available from: http://hdl.handle.net/1866/4698

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Georgia Tech

20. Pak, Richard. An investigation of perceptual load, aging, and the functional field of view.

Degree: PhD, Psychology, 2005, Georgia Tech

 A common metaphor for visual attention is the spotlight (Posner, 1980). It follows from the spotlight metaphor and other similar models (e.g., zoom-lens model; Eriksen… (more)

Subjects/Keywords: Perceptual load; FFOV; Aging; Functional field of view; Selectivity (Psychology); Visual perception; Aging; Attention

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Pak, R. (2005). An investigation of perceptual load, aging, and the functional field of view. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/7585

Chicago Manual of Style (16th Edition):

Pak, Richard. “An investigation of perceptual load, aging, and the functional field of view.” 2005. Doctoral Dissertation, Georgia Tech. Accessed November 12, 2019. http://hdl.handle.net/1853/7585.

MLA Handbook (7th Edition):

Pak, Richard. “An investigation of perceptual load, aging, and the functional field of view.” 2005. Web. 12 Nov 2019.

Vancouver:

Pak R. An investigation of perceptual load, aging, and the functional field of view. [Internet] [Doctoral dissertation]. Georgia Tech; 2005. [cited 2019 Nov 12]. Available from: http://hdl.handle.net/1853/7585.

Council of Science Editors:

Pak R. An investigation of perceptual load, aging, and the functional field of view. [Doctoral Dissertation]. Georgia Tech; 2005. Available from: http://hdl.handle.net/1853/7585

21. Gabl, Michael. Modulation of Receptor Signaling and Functional Selectivity in Neutrophils.

Degree: 2017, University of Gothenburg / Göteborgs Universitet

 Neutrophils are important effector cells of the innate immune system and in the regulation of inflammation. Many of their functions, such as chemotactic migration, secretion… (more)

Subjects/Keywords: neutrophils; G-protein coupled receptors; reactive oxygen species; ligands; functional selectivity; allosteric modulation

…56 Functional Selectivity… …certain morphological and functional changes and they are transferred from a resting to a primed… …TLR11 is a non-functional pseudogene and TLR12 and 13 are lacking [80]. Human… 

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Gabl, M. (2017). Modulation of Receptor Signaling and Functional Selectivity in Neutrophils. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/52860

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Gabl, Michael. “Modulation of Receptor Signaling and Functional Selectivity in Neutrophils.” 2017. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed November 12, 2019. http://hdl.handle.net/2077/52860.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Gabl, Michael. “Modulation of Receptor Signaling and Functional Selectivity in Neutrophils.” 2017. Web. 12 Nov 2019.

Vancouver:

Gabl M. Modulation of Receptor Signaling and Functional Selectivity in Neutrophils. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 2017. [cited 2019 Nov 12]. Available from: http://hdl.handle.net/2077/52860.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gabl M. Modulation of Receptor Signaling and Functional Selectivity in Neutrophils. [Thesis]. University of Gothenburg / Göteborgs Universitet; 2017. Available from: http://hdl.handle.net/2077/52860

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

22. Martí Solano, Maria. Ligand selectivity at GPCRs: from multitarget binding profiles to biased agonism.

Degree: Departament de Ciències Experimentals i de la Salut, 2015, Universitat Pompeu Fabra

 Deeper characterization of drugs targeting G protein-coupled receptors (GPCR)s has shown that their mechanisms of action can be more complex than previously thought. On the… (more)

Subjects/Keywords: GPCR; Afinitat d’unió; Selectivitat funcional; Serotonina; Farmacoinformàtica; Binding affinity; Functional selectivity; Serotonin; Pharmacoinformatics; 615

…pathway or functional selectivity and analyze its potential impact in different therapeutic… …functional selectivity at the 2A serotonin receptor, an important antipsychotic drug target… …receptors: implications for functional selectivity 173 xv 3.5 Detection of new biased agonists… …with wanted and unwanted effects. 4 1.3 Functional selectivity and its therapeutic… …different type of selectivity, namely functional selectivity. Functional selectivity is a property… 

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Martí Solano, M. (2015). Ligand selectivity at GPCRs: from multitarget binding profiles to biased agonism. (Thesis). Universitat Pompeu Fabra. Retrieved from http://hdl.handle.net/10803/285964

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Martí Solano, Maria. “Ligand selectivity at GPCRs: from multitarget binding profiles to biased agonism.” 2015. Thesis, Universitat Pompeu Fabra. Accessed November 12, 2019. http://hdl.handle.net/10803/285964.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Martí Solano, Maria. “Ligand selectivity at GPCRs: from multitarget binding profiles to biased agonism.” 2015. Web. 12 Nov 2019.

Vancouver:

Martí Solano M. Ligand selectivity at GPCRs: from multitarget binding profiles to biased agonism. [Internet] [Thesis]. Universitat Pompeu Fabra; 2015. [cited 2019 Nov 12]. Available from: http://hdl.handle.net/10803/285964.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Martí Solano M. Ligand selectivity at GPCRs: from multitarget binding profiles to biased agonism. [Thesis]. Universitat Pompeu Fabra; 2015. Available from: http://hdl.handle.net/10803/285964

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


University of California – San Francisco

23. Chang, Wei Chun. Controlling the Agonist-Mediated and Constitutive G-Protein Signaling of the Human 5-HT4 Receptor.

Degree: Pharmaceutical Sciences and Pharmacogenomics, 2007, University of California – San Francisco

 G-protein-coupled receptors (GPCRs) signal through a limited number of G-protein pathways and are crucial in many biological processes. The molecular and functional diversity of GPCRs… (more)

Subjects/Keywords: Biology, Cell; GPCR; RASSL; 5HT4; domain swapping; chimera; G protein signaling; agonist mediated; constitutive signaling; functional selectivity

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Chang, W. C. (2007). Controlling the Agonist-Mediated and Constitutive G-Protein Signaling of the Human 5-HT4 Receptor. (Thesis). University of California – San Francisco. Retrieved from http://www.escholarship.org/uc/item/6hf4j89w

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Chang, Wei Chun. “Controlling the Agonist-Mediated and Constitutive G-Protein Signaling of the Human 5-HT4 Receptor.” 2007. Thesis, University of California – San Francisco. Accessed November 12, 2019. http://www.escholarship.org/uc/item/6hf4j89w.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Chang, Wei Chun. “Controlling the Agonist-Mediated and Constitutive G-Protein Signaling of the Human 5-HT4 Receptor.” 2007. Web. 12 Nov 2019.

Vancouver:

Chang WC. Controlling the Agonist-Mediated and Constitutive G-Protein Signaling of the Human 5-HT4 Receptor. [Internet] [Thesis]. University of California – San Francisco; 2007. [cited 2019 Nov 12]. Available from: http://www.escholarship.org/uc/item/6hf4j89w.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chang WC. Controlling the Agonist-Mediated and Constitutive G-Protein Signaling of the Human 5-HT4 Receptor. [Thesis]. University of California – San Francisco; 2007. Available from: http://www.escholarship.org/uc/item/6hf4j89w

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

24. Janevski, G. Alex. Causes and Consequences of Extinction and Survival in Fossil Marine Invertebrates with a Special Focus on the Crinoidea (Phylum Echinodermata).

Degree: PhD, Geology, 2011, University of Michigan

 In the geologic past, certain traits increased the chance of survival of some marine invertebrate taxa, which means that extinction did not occur randomly. However,… (more)

Subjects/Keywords: Extinction Selectivity; Phylogeny; Crinoids; Marine Invertebrates; Biomechanics; Functional Morphology; Geology and Earth Sciences; Science

…Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . Functional morphology of swimming… …selectivity increases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Observed extinction… …the contribution of regional selectivity to observed extinction selectivity patterns… …ix 19 36 53 91 91 104 LIST OF APPENDICES Appendix A. Evidence for selectivity for… …the P-Tr extinction event? Did extinction selectivity affect crinoids during this event? The… 

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APA (6th Edition):

Janevski, G. A. (2011). Causes and Consequences of Extinction and Survival in Fossil Marine Invertebrates with a Special Focus on the Crinoidea (Phylum Echinodermata). (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/84527

Chicago Manual of Style (16th Edition):

Janevski, G Alex. “Causes and Consequences of Extinction and Survival in Fossil Marine Invertebrates with a Special Focus on the Crinoidea (Phylum Echinodermata).” 2011. Doctoral Dissertation, University of Michigan. Accessed November 12, 2019. http://hdl.handle.net/2027.42/84527.

MLA Handbook (7th Edition):

Janevski, G Alex. “Causes and Consequences of Extinction and Survival in Fossil Marine Invertebrates with a Special Focus on the Crinoidea (Phylum Echinodermata).” 2011. Web. 12 Nov 2019.

Vancouver:

Janevski GA. Causes and Consequences of Extinction and Survival in Fossil Marine Invertebrates with a Special Focus on the Crinoidea (Phylum Echinodermata). [Internet] [Doctoral dissertation]. University of Michigan; 2011. [cited 2019 Nov 12]. Available from: http://hdl.handle.net/2027.42/84527.

Council of Science Editors:

Janevski GA. Causes and Consequences of Extinction and Survival in Fossil Marine Invertebrates with a Special Focus on the Crinoidea (Phylum Echinodermata). [Doctoral Dissertation]. University of Michigan; 2011. Available from: http://hdl.handle.net/2027.42/84527

25. Karpinsky-Semper, Darla. The Structural Basis of Gβ5-RGS7 Interaction with the Muscarinic M3 Receptor and Implications for its Role in Functional Pathway Selectivity.

Degree: PhD, Molecular and Cellular Pharmacology (Medicine), 2014, University of Miami

  The neurotransmitter acetylcholine (Ach) is arguably the most important in the CNS. Two classes of receptors are activated by Ach: nicotinic (ionotropic) and muscarinic… (more)

Subjects/Keywords: Gβ5-RGS7; G protein-coupled receptor; muscarinic M3 receptor; Ca2+ signaling; functional selectivity

…conferred functional selectivity of M3R regulation by Gβ5-RGS7… …Fig. 3.16). The terms biased agonism, functional selectivity, agonist trafficking or… …ligand bias are interchangeable. Functional selectivity is not only a consequence of receptor G… …4.4 The central 85 amino acids of the M3R i3 loop may dictate selectivity for Gβ5-RGS7… …different G proteins identified specific receptor regions involved in selectivity of G protein… 

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APA (6th Edition):

Karpinsky-Semper, D. (2014). The Structural Basis of Gβ5-RGS7 Interaction with the Muscarinic M3 Receptor and Implications for its Role in Functional Pathway Selectivity. (Doctoral Dissertation). University of Miami. Retrieved from https://scholarlyrepository.miami.edu/oa_dissertations/1312

Chicago Manual of Style (16th Edition):

Karpinsky-Semper, Darla. “The Structural Basis of Gβ5-RGS7 Interaction with the Muscarinic M3 Receptor and Implications for its Role in Functional Pathway Selectivity.” 2014. Doctoral Dissertation, University of Miami. Accessed November 12, 2019. https://scholarlyrepository.miami.edu/oa_dissertations/1312.

MLA Handbook (7th Edition):

Karpinsky-Semper, Darla. “The Structural Basis of Gβ5-RGS7 Interaction with the Muscarinic M3 Receptor and Implications for its Role in Functional Pathway Selectivity.” 2014. Web. 12 Nov 2019.

Vancouver:

Karpinsky-Semper D. The Structural Basis of Gβ5-RGS7 Interaction with the Muscarinic M3 Receptor and Implications for its Role in Functional Pathway Selectivity. [Internet] [Doctoral dissertation]. University of Miami; 2014. [cited 2019 Nov 12]. Available from: https://scholarlyrepository.miami.edu/oa_dissertations/1312.

Council of Science Editors:

Karpinsky-Semper D. The Structural Basis of Gβ5-RGS7 Interaction with the Muscarinic M3 Receptor and Implications for its Role in Functional Pathway Selectivity. [Doctoral Dissertation]. University of Miami; 2014. Available from: https://scholarlyrepository.miami.edu/oa_dissertations/1312

26. Peterson, Sean Michael. Functional Selectivity at the Dopamine D2 Receptor .

Degree: 2015, Duke University

  The neuromodulator dopamine signals through the dopamine D2 receptor (D2R) to modulate central nervous system functions through diverse signal transduction pathways. D2R is a… (more)

Subjects/Keywords: Cellular biology; Pharmacology; Dopamine; Functional Selectivity; GPCR; G protein; β-arrestin

…36 Table II: Evolutionary Action predicted functional selectivity phenotype mutations in… …91 Table IV: Receptor manipulations yield operationally defined functional selectivity… …Ligand contributions to functional selectivity. Calculated from Figures 9 and 10. *p<0.05 when… …Table VI: Transducer contributions to functional selectivity. Calculated from Figure 11. *p… …94 viii List of Figures Figure 1: The functional selectivity of D2R. (A)… 

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APA (6th Edition):

Peterson, S. M. (2015). Functional Selectivity at the Dopamine D2 Receptor . (Thesis). Duke University. Retrieved from http://hdl.handle.net/10161/10500

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Peterson, Sean Michael. “Functional Selectivity at the Dopamine D2 Receptor .” 2015. Thesis, Duke University. Accessed November 12, 2019. http://hdl.handle.net/10161/10500.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Peterson, Sean Michael. “Functional Selectivity at the Dopamine D2 Receptor .” 2015. Web. 12 Nov 2019.

Vancouver:

Peterson SM. Functional Selectivity at the Dopamine D2 Receptor . [Internet] [Thesis]. Duke University; 2015. [cited 2019 Nov 12]. Available from: http://hdl.handle.net/10161/10500.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Peterson SM. Functional Selectivity at the Dopamine D2 Receptor . [Thesis]. Duke University; 2015. Available from: http://hdl.handle.net/10161/10500

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Université de Montréal

27. Charfi, Iness. Étude des propriétés de signalisation et de trafic du récepteur delta opiacé : vers une meilleure compréhension des bases cellulaires de la tolérance analgésique aux opioïdes .

Degree: 2018, Université de Montréal

Subjects/Keywords: RCPG; DOPr; Signalisation; Internalisation; Sélectivité fonctionnelle; Modèle opérationnel; Recyclage; TGN; Rab9; TIP47; ALIX; Tolérance analgésique; GPCR; Signaling; Internalization; Functional selectivity; Operational model; Recycling; Analgesic tolerance

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Charfi, I. (2018). Étude des propriétés de signalisation et de trafic du récepteur delta opiacé : vers une meilleure compréhension des bases cellulaires de la tolérance analgésique aux opioïdes . (Thesis). Université de Montréal. Retrieved from http://hdl.handle.net/1866/21203

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Charfi, Iness. “Étude des propriétés de signalisation et de trafic du récepteur delta opiacé : vers une meilleure compréhension des bases cellulaires de la tolérance analgésique aux opioïdes .” 2018. Thesis, Université de Montréal. Accessed November 12, 2019. http://hdl.handle.net/1866/21203.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Charfi, Iness. “Étude des propriétés de signalisation et de trafic du récepteur delta opiacé : vers une meilleure compréhension des bases cellulaires de la tolérance analgésique aux opioïdes .” 2018. Web. 12 Nov 2019.

Vancouver:

Charfi I. Étude des propriétés de signalisation et de trafic du récepteur delta opiacé : vers une meilleure compréhension des bases cellulaires de la tolérance analgésique aux opioïdes . [Internet] [Thesis]. Université de Montréal; 2018. [cited 2019 Nov 12]. Available from: http://hdl.handle.net/1866/21203.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Charfi I. Étude des propriétés de signalisation et de trafic du récepteur delta opiacé : vers une meilleure compréhension des bases cellulaires de la tolérance analgésique aux opioïdes . [Thesis]. Université de Montréal; 2018. Available from: http://hdl.handle.net/1866/21203

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

28. Strachan, Ryan Thomas. P90 Ribosomal S6 Kinase 2 (RSK2) Directly Phosphorylates the 5-HT2A Serotonin Receptor thereby Modulating Signaling.

Degree: PhD, Biochemistry, 2009, Case Western Reserve University

 Given the pivotal role G protein-coupled receptors (GPCRs) play in physiological responses, various mechanisms have evolved to ensure the tight regulation of GPCR signaling. Classically,… (more)

Subjects/Keywords: Biochemistry; Pharmacology; serotonin; 5-HT; 5-HT2A; GPCR; RSK; ERK; phosphorylation; RTK; growth factor; functional selectivity; biased agonism

…Differentially Affects Agonist Signaling Thereby Promoting Altered Patterns of Functional Selectivity… …of functional selectivity. These studies ultimately led to the larger discovery that RSK2… …functional selectivity‘, has profound implications for drug discovery and will be discussed in… …x29;. However, functional experiments and low-resolution biophysical studies have provided… 

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APA (6th Edition):

Strachan, R. T. (2009). P90 Ribosomal S6 Kinase 2 (RSK2) Directly Phosphorylates the 5-HT2A Serotonin Receptor thereby Modulating Signaling. (Doctoral Dissertation). Case Western Reserve University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1247172805

Chicago Manual of Style (16th Edition):

Strachan, Ryan Thomas. “P90 Ribosomal S6 Kinase 2 (RSK2) Directly Phosphorylates the 5-HT2A Serotonin Receptor thereby Modulating Signaling.” 2009. Doctoral Dissertation, Case Western Reserve University. Accessed November 12, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=case1247172805.

MLA Handbook (7th Edition):

Strachan, Ryan Thomas. “P90 Ribosomal S6 Kinase 2 (RSK2) Directly Phosphorylates the 5-HT2A Serotonin Receptor thereby Modulating Signaling.” 2009. Web. 12 Nov 2019.

Vancouver:

Strachan RT. P90 Ribosomal S6 Kinase 2 (RSK2) Directly Phosphorylates the 5-HT2A Serotonin Receptor thereby Modulating Signaling. [Internet] [Doctoral dissertation]. Case Western Reserve University; 2009. [cited 2019 Nov 12]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1247172805.

Council of Science Editors:

Strachan RT. P90 Ribosomal S6 Kinase 2 (RSK2) Directly Phosphorylates the 5-HT2A Serotonin Receptor thereby Modulating Signaling. [Doctoral Dissertation]. Case Western Reserve University; 2009. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1247172805


Vrije Universiteit Amsterdam

29. Kooistra, A.J. In silico Medicinal Chemistry: Investigating GPCRs: key regulators of signal transduction and cell function .

Degree: 2015, Vrije Universiteit Amsterdam

Subjects/Keywords: GPCRs; virtual screening; membrane proteins; transmembrane proteins; computer-aided drug design; chemogenomics; functional selectivity; histamine receptor; adrenoceptor; antihistamine; site-directed mutagenesis; structure-affinity relationship; protein-ligand interactions; GPCR crystal structures

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APA (6th Edition):

Kooistra, A. J. (2015). In silico Medicinal Chemistry: Investigating GPCRs: key regulators of signal transduction and cell function . (Doctoral Dissertation). Vrije Universiteit Amsterdam. Retrieved from http://hdl.handle.net/1871/52308

Chicago Manual of Style (16th Edition):

Kooistra, A J. “In silico Medicinal Chemistry: Investigating GPCRs: key regulators of signal transduction and cell function .” 2015. Doctoral Dissertation, Vrije Universiteit Amsterdam. Accessed November 12, 2019. http://hdl.handle.net/1871/52308.

MLA Handbook (7th Edition):

Kooistra, A J. “In silico Medicinal Chemistry: Investigating GPCRs: key regulators of signal transduction and cell function .” 2015. Web. 12 Nov 2019.

Vancouver:

Kooistra AJ. In silico Medicinal Chemistry: Investigating GPCRs: key regulators of signal transduction and cell function . [Internet] [Doctoral dissertation]. Vrije Universiteit Amsterdam; 2015. [cited 2019 Nov 12]. Available from: http://hdl.handle.net/1871/52308.

Council of Science Editors:

Kooistra AJ. In silico Medicinal Chemistry: Investigating GPCRs: key regulators of signal transduction and cell function . [Doctoral Dissertation]. Vrije Universiteit Amsterdam; 2015. Available from: http://hdl.handle.net/1871/52308


Australian National University

30. Lording, William James. A deeper understanding of the Diels–Alder reaction .

Degree: 2014, Australian National University

 The Diels-Alder reaction was discovered in 1928 and has become the most efficient and practical method for the synthesis of six-membered carbocyclic and heterocyclic rings.… (more)

Subjects/Keywords: organic chemistry; physical organic chemistry; chemical synthesis; chemical kinetics; computational chemistry; density functional theory; DFT; nuclear magnetic resonance; NMR; Diels-Alder; Diels-Alder reaction; 4+2 cycloaddition; cycloaddition; 4+2 diene; dienophile; cyclohexene; stereochemistry; stereoselectivity; endo-exo selectivity; endo selective; exo selective; secondary orbital interaction; SOI; electrostatic interaction; butadiene; deuterium; isotopic label; kinetic isotope effect; KIE; natural abundance; transition structure; intramolecular Diels-Alder reaction; rate study; transition state; activation barrier

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APA (6th Edition):

Lording, W. J. (2014). A deeper understanding of the Diels–Alder reaction . (Thesis). Australian National University. Retrieved from http://hdl.handle.net/1885/11776

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Lording, William James. “A deeper understanding of the Diels–Alder reaction .” 2014. Thesis, Australian National University. Accessed November 12, 2019. http://hdl.handle.net/1885/11776.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Lording, William James. “A deeper understanding of the Diels–Alder reaction .” 2014. Web. 12 Nov 2019.

Vancouver:

Lording WJ. A deeper understanding of the Diels–Alder reaction . [Internet] [Thesis]. Australian National University; 2014. [cited 2019 Nov 12]. Available from: http://hdl.handle.net/1885/11776.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lording WJ. A deeper understanding of the Diels–Alder reaction . [Thesis]. Australian National University; 2014. Available from: http://hdl.handle.net/1885/11776

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

[1] [2]

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