subject:(forced vergence cover test)

The Ohio State University

1. Toole, Andrew J. The Effects of Forced Vergence Cover Tests and the Burst Vergence Response on Phoria Adaptation.

Degree: PhD, Physiological Optics, 2008, The Ohio State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1211893739

► Symptoms associated with binocular vision disorders are attributed to stress on the disparity vergence system. This system is composed of an open-loop burst signal… (more)

▼ Symptoms associated with binocular vision disorders are attributed to stress on the disparity vergence system. This system is composed of an open-loop burst signal that initiates changes in the ocular vergence angle, and a closed-loop sustained response that completes and maintains this angle. Disparity vergence also contains an adaptable component known as phoria adaptation (PA). The ability of the sustained response to generate PA has been extensively studied, however little is known regarding the burst signal's contribution to PA. The phoria is the ocular angle in the absence of a disparity vergence response. However the time course for depleting PA makes measuring the true phoria challenging and is typically done by extended periods of monocular occlusion. As these extended periods of occlusion are not practical in a clinical setting, two forced vergence cover test (FVCT) procedures have previously been proposed for rapidly depleting PA and revealing the true phoria. In a series of experiments, this study evaluated these FVCT procedures and the burst vergence contribution to PA. The FVCTs were performed before and after significant PA was generated by fifteen minutes of binocularly viewing through base-out prisms. Pre- and post-adaptation FVCT results were significantly different (p<0.01) indicating that the procedures did not eliminate existing phoria adaptation. In a second experiment, PA generated in response to three over-convergence adapting scenarios was measured. These scenarios consisted of 30-seconds of steady fusion (steady), 3-seconds of fusion (quick-step), 27-seconds of a flashed target presentation (flash) that repeatedly presented the stimuli binocularly when subjects were under-converged, and monocularly when subject's vergence angle was near that required of the stimuli; the flash period concluded with 3-seconds of fusion. The flash period was designed to generate repeated burst vergence responses with minimal influence from the closed-loop response. Greater PA was generated by the flash period than the quick-step (p=0.025). Equivalent PA was found following the flash and the steady periods. In conclusion, currently described FVCT procedures do not eliminate PA and thus are unlikely to reveal the true phoria. Additionally, the burst vergence response can generate significant PA. Advisors/Committee Members: Fogt, Nicklaus (Advisor).

Subjects/Keywords: Ophthalmology; phoria; phoria adaptation; vergence; vergence adaptation; cover test; forced vergence cover test; burst vergence response

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APA (6^th Edition):

Toole, A. J. (2008). The Effects of Forced Vergence Cover Tests and the Burst Vergence Response on Phoria Adaptation. (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1211893739

Chicago Manual of Style (16^th Edition):

Toole, Andrew J. “The Effects of Forced Vergence Cover Tests and the Burst Vergence Response on Phoria Adaptation.” 2008. Doctoral Dissertation, The Ohio State University. Accessed April 10, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu1211893739.

MLA Handbook (7^th Edition):

Toole, Andrew J. “The Effects of Forced Vergence Cover Tests and the Burst Vergence Response on Phoria Adaptation.” 2008. Web. 10 Apr 2021.

Vancouver:

Toole AJ. The Effects of Forced Vergence Cover Tests and the Burst Vergence Response on Phoria Adaptation. [Internet] [Doctoral dissertation]. The Ohio State University; 2008. [cited 2021 Apr 10]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1211893739.

Council of Science Editors:

Toole AJ. The Effects of Forced Vergence Cover Tests and the Burst Vergence Response on Phoria Adaptation. [Doctoral Dissertation]. The Ohio State University; 2008. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1211893739

The Ohio State University

2. Fenton, Rachel. Role of Accommodation in Clinical Measures of Proximal Vergence.

Degree: MS, Vision Science, 2019, The Ohio State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1555572551774614

► Proximal vergence is the subtype of vergence that is stimulated by visual cues other than blur and disparity. There are two major clinical methods to… (more)

▼ Proximal vergence is the subtype of vergence that is stimulated by visual cues other than blur and disparity. There are two major clinical methods to assess proximal vergence. In one of these methods, termed the AC/A differencing method, proximal vergence is determined by calculating the difference in vergence change from the far-near AC/A method and the vergence change from the gradient AC/A method (equated for the accommodative demand). In the other method, termed the +2.50D method, the change in vergence posture between distance viewing and near viewing through a +2.50D lens is calculated. In assessing these values, it is typically assumed that response accommodation matched the change in accommodative demand from distance to near, which would be 2.50D for a 40cm near viewing distance. However, individuals often do not alter their accommodation by the amount of the accommodative demand. Therefore, proximal values calculated using accommodative responses might vary from proximal values that are calculated using the accommodative demand. The purpose of the present research is to determine the extent to which response accommodation could influence these methods of assessing proximal vergence, in order to better understand how proximal vergence is measured and therefore to better understand the relationship between proximal vergence and the other vergence subtypes in future studies. Thirteen subjects were recruited, ages 22-37, who underwent a battery of measurements consisting of interpupillary distance, visual acuity, stereoacuity, accommodative amplitudes, step vergence ranges, distance heterophoria, and near heterophoria using various refractive lenses. A Grand Seiko WR5100K autorefractor measured accommodation. Accommodative data revealed high accommodative lags in many subjects, which influenced response AC/A ratios and response proximal vergence results. Proximal vergence was then calculated in four distinct ways, two based on stimulus measurements and two taking response accommodation into consideration. Statistical analysis using t-tests showed no statistically significant difference between any of these proximal vergence calculations after using the Bonferonni correction (p>0.0083 for all comparisons). Additionally, no statistically significant relationship between measures of fusional vergence and measures for proximal vergence were found (p>0.05) using linear regression analysis. In conclusion, this study found that all four clinical methods, using stimulus and response measurements, yielded similar values. Advisors/Committee Members: Fogt, Nicklaus (Advisor).

Subjects/Keywords: Ophthalmology; Vergence, Proximal Vergence, Accommodation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Fenton, R. (2019). Role of Accommodation in Clinical Measures of Proximal Vergence. (Masters Thesis). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1555572551774614

Chicago Manual of Style (16^th Edition):

Fenton, Rachel. “Role of Accommodation in Clinical Measures of Proximal Vergence.” 2019. Masters Thesis, The Ohio State University. Accessed April 10, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu1555572551774614.

MLA Handbook (7^th Edition):

Fenton, Rachel. “Role of Accommodation in Clinical Measures of Proximal Vergence.” 2019. Web. 10 Apr 2021.

Vancouver:

Fenton R. Role of Accommodation in Clinical Measures of Proximal Vergence. [Internet] [Masters thesis]. The Ohio State University; 2019. [cited 2021 Apr 10]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1555572551774614.

Council of Science Editors:

Fenton R. Role of Accommodation in Clinical Measures of Proximal Vergence. [Masters Thesis]. The Ohio State University; 2019. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1555572551774614

George Mason University

3. Beech, Erin H. The Effects of Excess Zinc and Copper on Anxiety and Depression in a Rat Model .

Degree: 2012, George Mason University

URL: http://hdl.handle.net/1920/7904

► Zinc deficiency is associated with both anxiety and depression in animal models. Zinc supplementation reduces depression-like behaviors in the forced swim test and increases grooming… (more)

▼ Zinc deficiency is associated with both anxiety and depression in animal models. Zinc supplementation reduces depression-like behaviors in the forced swim test and increases grooming behavior and line crossing in the open field test. Zinc is a toxin, however, and excess zinc has been associated with increased anxiety-like behaviors, including a reduced ability to extinguish fear and greater thigmotaxicity in the Morris water maze. The addition of copper was reported to remediate the negative effects of zinc supplementation in this case. Many of the studies reporting the anti-depressant and anti-anxiety effects of zinc supplementation employed a single, acute zinc dose, or treatment over a short period of time. This study employed a chronic, pre- and post-natal zinc supplementation paradigm to determine if there would be a difference between zinc, zinc plus copper, or lab water fed rats, on behavioral measures of anxiety and depression in rats. It was hypothesized that the zinc-supplemented rats would display a higher amount of anxiety- and depression-like behaviors than controls, and that the zinc + plus copper animals would show fewer anxiety- and depression-like behaviors than the zinc-supplemented rats, similar to controls. However, the results showed that there was no difference in depression-like behaviors between the groups on the forced swim test. There was also no difference in anxiety-like behaviors between the groups on the elevated plus maze or on day one of the open field test. On day two of the open field test, there was a significant interaction between water group and time. The zinc rats spent more time in the center at the end of the trial than at the beginning, while the zinc + copper animals and the lab animals spent less time in the center at the end of the trial than at the beginning. The multiple, conflicting results in this field of research may be due to the complex mechanisms behind the relationship between zinc homeostasis and affective disorders, but are more likely due to differences in methodology and high variability. Although zinc supplementation seems to be a promising treatment, it should seek to restore zinc homeostasis without leading to a state of excess zinc. Advisors/Committee Members: Flinn, Jane M (advisor).

Subjects/Keywords: zinc; anxiety; depression; openfield; elevated plus maze; forced swim test

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APA (6^th Edition):

Beech, E. H. (2012). The Effects of Excess Zinc and Copper on Anxiety and Depression in a Rat Model . (Thesis). George Mason University. Retrieved from http://hdl.handle.net/1920/7904

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Beech, Erin H. “The Effects of Excess Zinc and Copper on Anxiety and Depression in a Rat Model .” 2012. Thesis, George Mason University. Accessed April 10, 2021. http://hdl.handle.net/1920/7904.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Beech, Erin H. “The Effects of Excess Zinc and Copper on Anxiety and Depression in a Rat Model .” 2012. Web. 10 Apr 2021.

Vancouver:

Beech EH. The Effects of Excess Zinc and Copper on Anxiety and Depression in a Rat Model . [Internet] [Thesis]. George Mason University; 2012. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/1920/7904.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Beech EH. The Effects of Excess Zinc and Copper on Anxiety and Depression in a Rat Model . [Thesis]. George Mason University; 2012. Available from: http://hdl.handle.net/1920/7904

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Toronto

4. Liu, Junhan. Effects of Cannabidiol and delta-9-Tetrahydrocannabinol in The Elevated Plus Maze and Forced Swim Tests.

Degree: 2019, University of Toronto

URL: http://hdl.handle.net/1807/102969

►

The effects of THC, CBD and a combination of CBD and THC (15:1) were tested in mice models of anxiety (elevated plus maze EPM) and… (more)

Subjects/Keywords: cannabidiol; cannabis; elevated plus maze; forced swim test; mice; tetrahydrocannabinol; 0419

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Liu, J. (2019). Effects of Cannabidiol and delta-9-Tetrahydrocannabinol in The Elevated Plus Maze and Forced Swim Tests. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/102969

Chicago Manual of Style (16^th Edition):

Liu, Junhan. “Effects of Cannabidiol and delta-9-Tetrahydrocannabinol in The Elevated Plus Maze and Forced Swim Tests.” 2019. Masters Thesis, University of Toronto. Accessed April 10, 2021. http://hdl.handle.net/1807/102969.

MLA Handbook (7^th Edition):

Liu, Junhan. “Effects of Cannabidiol and delta-9-Tetrahydrocannabinol in The Elevated Plus Maze and Forced Swim Tests.” 2019. Web. 10 Apr 2021.

Vancouver:

Liu J. Effects of Cannabidiol and delta-9-Tetrahydrocannabinol in The Elevated Plus Maze and Forced Swim Tests. [Internet] [Masters thesis]. University of Toronto; 2019. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/1807/102969.

Council of Science Editors:

Liu J. Effects of Cannabidiol and delta-9-Tetrahydrocannabinol in The Elevated Plus Maze and Forced Swim Tests. [Masters Thesis]. University of Toronto; 2019. Available from: http://hdl.handle.net/1807/102969

5. MCDONNELL, CONOR WILLIAM. Investigation of ?-tubulins as translational biomarkers of major depressive disorder: indications for disease severity and treatment efficacy.

Degree: School of Medicine. Discipline of Psychiatry, 2020, Trinity College Dublin

URL: http://hdl.handle.net/2262/91857

► Introduction: Major Depressive Disorder is a significant cause of disability worldwide. In a 2017 report, the World Health Organisation estimated that 320 million people suffered… (more)

▼ Introduction: Major Depressive Disorder is a significant cause of disability worldwide. In a 2017 report, the World Health Organisation estimated that 320 million people suffered from depression globally. Although several antidepressant drugs have been delivered to the market over recent years, many patients do not respond adequately, or at all, to treatment. This has created an urgent need for safer and more effective treatments, which requires a better understanding of the underlying pathophysiology of depression. Disruption in neuronal plasticity; the ability of neurons to physically and functionally change over time, has been implicated in the pathophysiology of depression in both preclinical and clinical investigations. Microtubule dynamics, the rapid assembly and disassembly of microtubules and its constituents is a cellular mechanism allowing for neuronal plasticity. Microtubules contribute to this process primarily through axonal and dendritic remodelling that is required for the maintenance of synaptic connections. Microtubule stability and dynamic states affecting neuronal plasticity can be measured by assessing one of the microtubule heterodimers, Introduction: Major Depressive Disorder is a significant cause of disability worldwide. In a 2017 report, the World Health Organisation estimated that 320 million people suffered from depression globally. Although several antidepressant drugs have been delivered to the market over recent years, many patients do not respond adequately, or at all, to treatment. This has created an urgent need for safer and more effective treatments, which requires a better understanding of the underlying pathophysiology of depression. Disruption in neuronal plasticity; the ability of neurons to physically and functionally change over time, has been implicated in the pathophysiology of depression in both preclinical and clinical investigations. Microtubule dynamics, the rapid assembly and disassembly of microtubules and its constituents is a cellular mechanism allowing for neuronal plasticity. Microtubules contribute to this process primarily through axonal and dendritic remodelling that is required for the maintenance of synaptic connections. Microtubule stability and dynamic states affecting neuronal plasticity can be measured by assessing one of the microtubule heterodimers, ?-tubulin and its post-translational modifications. While ?-tubulins have been studied in the brain, they can also be detected in blood plasma, providing the possibility of peripheral detection of neuronal states. In order to evaluate if ?-tubulins indicate a depressed state and subsequently a treatment response, analysis of tissue from a preclinical model of depression and blood plasma from depressed individuals was conducted. Hypothesis: That ?-tubulins are biomarkers for depression severity and treatment efficacy. Methods: The Forced Swim Test was used to measure ?depressive-like? behaviour of Wistar Kyoto and Sprague Dawley rats following chronic or acute antidepressant treatment. Due to the reported… Advisors/Committee Members: Gill, Michael.

Subjects/Keywords: biomarker; depression; forced swim test; blood plasma; ?-tubulin

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

MCDONNELL, C. W. (2020). Investigation of ?-tubulins as translational biomarkers of major depressive disorder: indications for disease severity and treatment efficacy. (Thesis). Trinity College Dublin. Retrieved from http://hdl.handle.net/2262/91857

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

MCDONNELL, CONOR WILLIAM. “Investigation of ?-tubulins as translational biomarkers of major depressive disorder: indications for disease severity and treatment efficacy.” 2020. Thesis, Trinity College Dublin. Accessed April 10, 2021. http://hdl.handle.net/2262/91857.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

MCDONNELL, CONOR WILLIAM. “Investigation of ?-tubulins as translational biomarkers of major depressive disorder: indications for disease severity and treatment efficacy.” 2020. Web. 10 Apr 2021.

Vancouver:

MCDONNELL CW. Investigation of ?-tubulins as translational biomarkers of major depressive disorder: indications for disease severity and treatment efficacy. [Internet] [Thesis]. Trinity College Dublin; 2020. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/2262/91857.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

MCDONNELL CW. Investigation of ?-tubulins as translational biomarkers of major depressive disorder: indications for disease severity and treatment efficacy. [Thesis]. Trinity College Dublin; 2020. Available from: http://hdl.handle.net/2262/91857

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

6. Payne, Sean K. An Investigation of Anxiety- And Depression-Like Behavior after Head Trauma in Mice.

Degree: MA- Psychology, Psychology, 2020, Stephen F. Austin State University

URL: https://scholarworks.sfasu.edu/etds/301

► Every year around 2 million people in the United States (US) suffer a traumatic brain injury. Those people are often at a higher risk… (more)

Subjects/Keywords: TBI; anxiety; depression; zero maze; open field; forced swim test; Psychology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Payne, S. K. (2020). An Investigation of Anxiety- And Depression-Like Behavior after Head Trauma in Mice. (Masters Thesis). Stephen F. Austin State University. Retrieved from https://scholarworks.sfasu.edu/etds/301

Chicago Manual of Style (16^th Edition):

Payne, Sean K. “An Investigation of Anxiety- And Depression-Like Behavior after Head Trauma in Mice.” 2020. Masters Thesis, Stephen F. Austin State University. Accessed April 10, 2021. https://scholarworks.sfasu.edu/etds/301.

MLA Handbook (7^th Edition):

Payne, Sean K. “An Investigation of Anxiety- And Depression-Like Behavior after Head Trauma in Mice.” 2020. Web. 10 Apr 2021.

Vancouver:

Payne SK. An Investigation of Anxiety- And Depression-Like Behavior after Head Trauma in Mice. [Internet] [Masters thesis]. Stephen F. Austin State University; 2020. [cited 2021 Apr 10]. Available from: https://scholarworks.sfasu.edu/etds/301.

Council of Science Editors:

Payne SK. An Investigation of Anxiety- And Depression-Like Behavior after Head Trauma in Mice. [Masters Thesis]. Stephen F. Austin State University; 2020. Available from: https://scholarworks.sfasu.edu/etds/301

7. VALENTE, Thales Levi Azevedo. Metodologia Computacional para Detecção e Diagnóstico Automáticos de Estrabismo em Vídeos Digitais utilizando o Cover Test.

Degree: 2017, Universidade Federal do Maranhão; PROGRAMA DE PÓS-GRADUAÇÃO EM ENGENHARIA DE ELETRICIDADE/CCET; UFMA; Brasil; DEPARTAMENTO DE ENGENHARIA DA ELETRICIDADE/CCET

URL: http://tedebc.ufma.br:8080/jspui/handle/tede/1292

►

Submitted by Maria Aparecida ([email protected]) on 2017-04-17T11:42:26Z No. of bitstreams: 1 Thales Valente.pdf: 2116457 bytes, checksum: 1fe85262c104d5e919673a3d65e1fd56 (MD5)

Made available in DSpace on 2017-04-17T11:42:26Z (GMT).… (more)

▼

Submitted by Maria Aparecida ([email protected]) on 2017-04-17T11:42:26Z No. of bitstreams: 1 Thales Valente.pdf: 2116457 bytes, checksum: 1fe85262c104d5e919673a3d65e1fd56 (MD5)

Made available in DSpace on 2017-04-17T11:42:26Z (GMT). No. of bitstreams: 1 Thales Valente.pdf: 2116457 bytes, checksum: 1fe85262c104d5e919673a3d65e1fd56 (MD5) Previous issue date: 2017-02-03

CNPQ, TeCGraf/PUC-Rio

Medical image processing can contribute to the detection and diagnosis of human body anomalies, as an important toll to minimizes the degree of uncertainty in diagnosis, and provides specialists with an additional source of information. Strabismus is one of these anomalies, which affects approximately 4% of the population. Strabismus modify the mechanism of vision, resulting in aesthetical and sensory problems. The first case is reversible at any age. Regarding sensory problems, late treatment may lead to an irreversible condition. The cover test is one of the types of exams used to diagnose this pathology. The use of low cost computational resources to aid in the diagnosis and treatment within the strabismus subspecialty is not yet a reality. Therefore, this work presents a computational methodology to automatically pre-diagnosis strabismus through digital videos featuring cover test. To do this, the methodology was divided in 8 stages: Acquisition (1), Detection of eyes region (2), Location of pupil (3), Location of limbus (4) , Tracking eyes (5), Detection of occluder (6) , Detection (7) and Diagnosis of strabismus (8). The effectiveness of the method in the indication of the diagnosis was evaluated by comparisons made with the diagnosis provided by the expert. For detection of strabismus, the method proposed achieved 100% specificity, sensitivity of 80% and 93.33% accuracy and was demonstrated to be 87% accurate in diagnosing strabismus, while acknowledging measures lower than 1 prismatic diopter, and an average error of 2.57 prismatic diopters in deviation measure. So, was demonstrated the feasibility of using computational resources based on images processing techniques to achieve diagnosing strabismus through cover test.

O processamento de imagens médicas vem contribuindo para a detecção e o diagnóstico de anomalias no corpo humano, sendo uma importante ferramenta na redução do grau de incerteza do diagnóstico, provendo uma fonte adicional de informação aos especialistas. Uma dessas anomalias é o estrabismo, que afeta aproximadamente 4% da população e modifica o mecanismo de visão, resultando em problemas estéticos e sensoriais. O primeiro caso é reversível a qualquer idade. Já em relação aos problemas sensoriais, o tratamento tardio pode levar á um quadro irreversível. O cover test é um dos tipos de exames realizados para diagnosticar tal patologia. A utilização de recursos computacionais de baixo custo no auxílio diagnóstico e terapêutico dentro da subespecialidade estrabismo ainda não é uma realidade. Portanto, este trabalho apresenta uma metodologia computacional para pré-diagnosticar…

Advisors/Committee Members: SILVA, Aristófanes Corrêa.

Subjects/Keywords: Diagnóstico de estrabismo; Cover test; Processamento de imagens; Vídeos digitais; Diagnosis of strabismus; Cover test; Image processing; Digital videos; Engenharia Médica

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APA (6^th Edition):

VALENTE, T. L. A. (2017). Metodologia Computacional para Detecção e Diagnóstico Automáticos de Estrabismo em Vídeos Digitais utilizando o Cover Test. (Masters Thesis). Universidade Federal do Maranhão; PROGRAMA DE PÓS-GRADUAÇÃO EM ENGENHARIA DE ELETRICIDADE/CCET; UFMA; Brasil; DEPARTAMENTO DE ENGENHARIA DA ELETRICIDADE/CCET. Retrieved from http://tedebc.ufma.br:8080/jspui/handle/tede/1292

Chicago Manual of Style (16^th Edition):

VALENTE, Thales Levi Azevedo. “Metodologia Computacional para Detecção e Diagnóstico Automáticos de Estrabismo em Vídeos Digitais utilizando o Cover Test.” 2017. Masters Thesis, Universidade Federal do Maranhão; PROGRAMA DE PÓS-GRADUAÇÃO EM ENGENHARIA DE ELETRICIDADE/CCET; UFMA; Brasil; DEPARTAMENTO DE ENGENHARIA DA ELETRICIDADE/CCET. Accessed April 10, 2021. http://tedebc.ufma.br:8080/jspui/handle/tede/1292.

MLA Handbook (7^th Edition):

VALENTE, Thales Levi Azevedo. “Metodologia Computacional para Detecção e Diagnóstico Automáticos de Estrabismo em Vídeos Digitais utilizando o Cover Test.” 2017. Web. 10 Apr 2021.

Vancouver:

VALENTE TLA. Metodologia Computacional para Detecção e Diagnóstico Automáticos de Estrabismo em Vídeos Digitais utilizando o Cover Test. [Internet] [Masters thesis]. Universidade Federal do Maranhão; PROGRAMA DE PÓS-GRADUAÇÃO EM ENGENHARIA DE ELETRICIDADE/CCET; UFMA; Brasil; DEPARTAMENTO DE ENGENHARIA DA ELETRICIDADE/CCET; 2017. [cited 2021 Apr 10]. Available from: http://tedebc.ufma.br:8080/jspui/handle/tede/1292.

Council of Science Editors:

VALENTE TLA. Metodologia Computacional para Detecção e Diagnóstico Automáticos de Estrabismo em Vídeos Digitais utilizando o Cover Test. [Masters Thesis]. Universidade Federal do Maranhão; PROGRAMA DE PÓS-GRADUAÇÃO EM ENGENHARIA DE ELETRICIDADE/CCET; UFMA; Brasil; DEPARTAMENTO DE ENGENHARIA DA ELETRICIDADE/CCET; 2017. Available from: http://tedebc.ufma.br:8080/jspui/handle/tede/1292

NSYSU

8. Chen, Yen-Shuo. Research for polyethylene fibers Reinforced Concrete.

Degree: Master, Marine Environment and Engineering, 2012, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0524112-141602

► In this study, Dyneema fiber can bear tension and not easy to react with the chemicals characteristics, to explore for the resistance to bending moment… (more)

Subjects/Keywords: To cover the load test; Dyneema fiber; AE water-reducing; Component test

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APA (6^th Edition):

Chen, Y. (2012). Research for polyethylene fibers Reinforced Concrete. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0524112-141602

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chen, Yen-Shuo. “Research for polyethylene fibers Reinforced Concrete.” 2012. Thesis, NSYSU. Accessed April 10, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0524112-141602.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chen, Yen-Shuo. “Research for polyethylene fibers Reinforced Concrete.” 2012. Web. 10 Apr 2021.

Vancouver:

Chen Y. Research for polyethylene fibers Reinforced Concrete. [Internet] [Thesis]. NSYSU; 2012. [cited 2021 Apr 10]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0524112-141602.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chen Y. Research for polyethylene fibers Reinforced Concrete. [Thesis]. NSYSU; 2012. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0524112-141602

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

UCLA

9. Chen, Lingxuan. Novel Quantitative Analyses in Mouse Models of Neurological and Psychiatric Disorders.

Degree: Molec, Cell, & Integ Physiology, 2017, UCLA

URL: http://www.escholarship.org/uc/item/1gf2z8p9

► Numerous efforts have been made to illuminate the mechanisms underlying neurological and psychiatric disorders, in order to develop treatments for these diseases. With the advantage… (more)

▼ Numerous efforts have been made to illuminate the mechanisms underlying neurological and psychiatric disorders, in order to develop treatments for these diseases. With the advantage of transgenic mouse models to recapitulate human pathological alterations and to support drug screening, promising discoveries have been made over the past century. In this dissertation, I am focusing on Alzheimer’s disease (AD), which is a neurodegenerative disorder with significant public health concern. Using one of the newest mouse models of AD, the AppNL-F mouse model, I have investigated synaptic, network, and cognitive alterations related to this disease, with techniques from in vitro and in vivo electrophysiology for examining abnormalities in the brain to behavior tests for assessing the cognitive functions of the animals. In the meantime, novel quantitative approaches have been developed and applied to objectively interpret the experimental data. In AppNL-F homozygous mice, we have found synaptic alterations consistent with deficits in parvalbumin-expressing interneurons (PV INs). Moreover, through long-term in vivo local field potential (LFP) recording, we have discovered perturbed network activities associated with disrupted sleep patterns, which happened during a critical period in the disease progression and may lead to further cognitive deficits in these animals. Besides well-known cognitive dysfunctions such as loss of memory and reasoning as well as language difficulties, there is a second group of non-cognitive symptoms including psychiatric disorders and behavioral disturbances, such as depression, hallucination, delusions, and agitations(Burns et al., 1990; Burns and Iliffe, 2009). Therefore, I have also investigated into the mouse forced-swim test (FST), which is widely used in the screening of antidepressants. By quantitative analyses on this test, we have discovered a new confounding factor, and developed novel methods to determine the important parameters in the mouse FST, which could be applied to mouse AD models to study depression and the effect of antidepressants in AD. In conclusion, the application of quantitative approaches in neuroscience studies have led to the discovery of intriguing results and provided ground for exciting future research.

Subjects/Keywords: Neurosciences; Aging; Pathology; Alzheimer's disease; Electrophysiology; Forced swim test; Parvalbumin interneuron; Quantitative analysis; Synaptic transmission

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chen, L. (2017). Novel Quantitative Analyses in Mouse Models of Neurological and Psychiatric Disorders. (Thesis). UCLA. Retrieved from http://www.escholarship.org/uc/item/1gf2z8p9

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chen, Lingxuan. “Novel Quantitative Analyses in Mouse Models of Neurological and Psychiatric Disorders.” 2017. Thesis, UCLA. Accessed April 10, 2021. http://www.escholarship.org/uc/item/1gf2z8p9.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chen, Lingxuan. “Novel Quantitative Analyses in Mouse Models of Neurological and Psychiatric Disorders.” 2017. Web. 10 Apr 2021.

Vancouver:

Chen L. Novel Quantitative Analyses in Mouse Models of Neurological and Psychiatric Disorders. [Internet] [Thesis]. UCLA; 2017. [cited 2021 Apr 10]. Available from: http://www.escholarship.org/uc/item/1gf2z8p9.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chen L. Novel Quantitative Analyses in Mouse Models of Neurological and Psychiatric Disorders. [Thesis]. UCLA; 2017. Available from: http://www.escholarship.org/uc/item/1gf2z8p9

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

10. Carey, Lawrence, IV. ANTIDEPRESSANT EFFECTS OF THE NTS1 AGONIST PD149163 IN THE FORCED SWIM TEST.

Degree: MS, Psychology, 2014, Northen Michigan University

URL: https://commons.nmu.edu/theses/26

► Neurotensin is a neuropeptide that influences monoaminergic neurotransmission in areas of the brain involved in the pathophysiology of depression. The forced swim test is… (more)

Subjects/Keywords: Neurotensin; Depression; Forced Swim Test; Neuroscience and Neurobiology; Pharmacy and Pharmaceutical Sciences

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APA (6^th Edition):

Carey, Lawrence, I. (2014). ANTIDEPRESSANT EFFECTS OF THE NTS1 AGONIST PD149163 IN THE FORCED SWIM TEST. (Thesis). Northen Michigan University. Retrieved from https://commons.nmu.edu/theses/26

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Carey, Lawrence, IV. “ANTIDEPRESSANT EFFECTS OF THE NTS1 AGONIST PD149163 IN THE FORCED SWIM TEST.” 2014. Thesis, Northen Michigan University. Accessed April 10, 2021. https://commons.nmu.edu/theses/26.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Carey, Lawrence, IV. “ANTIDEPRESSANT EFFECTS OF THE NTS1 AGONIST PD149163 IN THE FORCED SWIM TEST.” 2014. Web. 10 Apr 2021.

Vancouver:

Carey, Lawrence I. ANTIDEPRESSANT EFFECTS OF THE NTS1 AGONIST PD149163 IN THE FORCED SWIM TEST. [Internet] [Thesis]. Northen Michigan University; 2014. [cited 2021 Apr 10]. Available from: https://commons.nmu.edu/theses/26.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Carey, Lawrence I. ANTIDEPRESSANT EFFECTS OF THE NTS1 AGONIST PD149163 IN THE FORCED SWIM TEST. [Thesis]. Northen Michigan University; 2014. Available from: https://commons.nmu.edu/theses/26

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas Tech University

11. Hulbert, Lindsey E. Stress and allergic pulmonary inflammation.

Degree: Animal and Food Sciences, 2006, Texas Tech University

URL: http://hdl.handle.net/2346/16233

► The interactions between stress and allergic pulmonary inflammation are not well understood. Experiments were conducted utilizing the ovalbulmin (OVA) sensitization and aerosol challenge to induce… (more)

Subjects/Keywords: Forced swim test; Amphetamine withdrawal; Ovalbumin

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APA (6^th Edition):

Hulbert, L. E. (2006). Stress and allergic pulmonary inflammation. (Thesis). Texas Tech University. Retrieved from http://hdl.handle.net/2346/16233

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hulbert, Lindsey E. “Stress and allergic pulmonary inflammation.” 2006. Thesis, Texas Tech University. Accessed April 10, 2021. http://hdl.handle.net/2346/16233.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hulbert, Lindsey E. “Stress and allergic pulmonary inflammation.” 2006. Web. 10 Apr 2021.

Vancouver:

Hulbert LE. Stress and allergic pulmonary inflammation. [Internet] [Thesis]. Texas Tech University; 2006. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/2346/16233.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hulbert LE. Stress and allergic pulmonary inflammation. [Thesis]. Texas Tech University; 2006. Available from: http://hdl.handle.net/2346/16233

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

12. Ariandra Guerini Sartim. Possível interação entre os sistemas endocanabinóide, glutamatérgico e nitrérgico do CPFmv na modulação de respostas emocionais/comportamentais ao estresse.

Degree: 2017, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/60/60138/tde-23112017-083836/

► Receptores CB1 e TRPV1 desempenham papéis opostos na modulação da atividade neuronal e, possivelmente, na regulação da resposta ao estresse. A exposição ao estresse reduz… (more)

▼ Receptores CB1 e TRPV1 desempenham papéis opostos na modulação da atividade neuronal e, possivelmente, na regulação da resposta ao estresse. A exposição ao estresse reduz a neurotransmissão mediada por receptores CB1, enquanto que a facilitação do sistema endocanabinóide produz efeito tipoantidepressivo. Por outro lado, estudos farmacológicos e de manipulação genética apontam que a diminuição da sinalização mediada por receptores TRPV1 produz efeito tipo-antidepressivo em modelos animais. Evidências científicas apontam que a modulação da neurotransmissão glutamatérgica, dependente de receptores NMDA, esteja envolvida em respostas mediadas por CB1 e TRPV1. Ambos os receptores são amplamente expressos em estruturas cerebrais envolvidas na resposta emocional, incluindo o córtex pré-frontal medial ventral (CPFmv), o que aponta para essa estrutura como importante alvo para os efeitos mediados por receptores CB1, TRPV1 e NMDA. Entretanto, pouco se sabe sobre a interação entre CB1 e TRPV1 corticais na resposta ao estresse. Dessa forma, avaliamos se receptores CB1 e TRPV1 localizados no CPFmv-pré-límbico (PL) podem contribuir, de maneiras opostas, para as mudanças comportamentais induzidas pelo estresse do teste do nado forçado (TNF), um teste preditivo de efeito tipo-antidepressivo. Em um primeiro grupo experimental observou-se que a AEA induz efeito tipo-antidepressivo com uma curva dose-resposta em U, quando administrada no CPFmv-PL. Além disso, o efeito tipo-antidepressivo da AEA foi prevenido pela pré-administração de AM251, um antagonista para receptores CB1. Por outro lado, a maior dose de AEA, que não induz efeito per se, produziu efeito tipo-antidepressivo quando combinada ao bloqueio de receptores TRPV1 por meio do pré-tratamento com SB366791. Corroborando estes dados, observou-se que a administração intra-CPFmv-PL de um bloqueador dual da enzima FAAH e de receptores TRPV1 (AA-5HT), induziu efeito tipo-antidepressivo no teste do nado forçado. Além disso, a administração do inibidor da FAAH (URB597) e do antagonista de receptores TRPV1 (SB366791), em grupos independentes de animais, reduziu o tempo de imobilidade no teste do nado forçado. Ademais, a coadministração de doses subefetivas de URB597 e SB366791 reduziu o tempo de imobilidade no mesmo teste comportamental, evidenciando somação de efeito do bloqueio combinado da FAAH com receptores TRPV1. Em conjunto, esses ii resultados indicam que tanto a facilitação da neurotransmissão mediada por CB1R quanto o bloqueio de TRPV1R no CPFmv-PL promove efeito tipo-antidepressivo, sugerindo que ambos os receptores corticais são importantes na modulação de respostas comportamentais ao estresse e, possivelmente, na neurobiologia da depressão, porém de maneiras opostas. Buscando elucidar os mecanismos pelos quais a AEA, através da ativação de CB1R e TRPV1R, promove seus efeitos comportamentais, o envolvimento da das neurotransmissões glutamatérgica e nitrérgica nos efeitos induzidos pela AEA foi investigado. Nossos resultados demonstraram que a administração de antagonista de… Advisors/Committee Members: Sâmia Regiane Lourenço Joca, Carlos Cesar Crestani, Vanessa Beijamini Harres, Helio Zangrossi Junior.

Subjects/Keywords: Depressão; Sistema endocanabinóide; Teste do nado forçado; Depression; Endocannabinoid system; Forced swimming test

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sartim, A. G. (2017). Possível interação entre os sistemas endocanabinóide, glutamatérgico e nitrérgico do CPFmv na modulação de respostas emocionais/comportamentais ao estresse. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/60/60138/tde-23112017-083836/

Chicago Manual of Style (16^th Edition):

Sartim, Ariandra Guerini. “Possível interação entre os sistemas endocanabinóide, glutamatérgico e nitrérgico do CPFmv na modulação de respostas emocionais/comportamentais ao estresse.” 2017. Doctoral Dissertation, University of São Paulo. Accessed April 10, 2021. http://www.teses.usp.br/teses/disponiveis/60/60138/tde-23112017-083836/.

MLA Handbook (7^th Edition):

Sartim, Ariandra Guerini. “Possível interação entre os sistemas endocanabinóide, glutamatérgico e nitrérgico do CPFmv na modulação de respostas emocionais/comportamentais ao estresse.” 2017. Web. 10 Apr 2021.

Vancouver:

Sartim AG. Possível interação entre os sistemas endocanabinóide, glutamatérgico e nitrérgico do CPFmv na modulação de respostas emocionais/comportamentais ao estresse. [Internet] [Doctoral dissertation]. University of São Paulo; 2017. [cited 2021 Apr 10]. Available from: http://www.teses.usp.br/teses/disponiveis/60/60138/tde-23112017-083836/.

Council of Science Editors:

Sartim AG. Possível interação entre os sistemas endocanabinóide, glutamatérgico e nitrérgico do CPFmv na modulação de respostas emocionais/comportamentais ao estresse. [Doctoral Dissertation]. University of São Paulo; 2017. Available from: http://www.teses.usp.br/teses/disponiveis/60/60138/tde-23112017-083836/

13. Almeida, Eduardo Farina de. Efeito antidepressivo e ansiolítico do extrato metanólico de Hibiscus tiliaceus em modelo animal de depressão pós-parto.

Degree: 2012, Brazil

URL: http://hdl.handle.net/10183/67656

►

Hibiscus tiliaceus L. (Malvaceae) é usado popularmente em desordens do pós-parto. O extrato metanólico de flores de H. tiliaceus apresentou atividade antidepressiva-like nos testes de… (more)

▼

Hibiscus tiliaceus L. (Malvaceae) é usado popularmente em desordens do pós-parto. O extrato metanólico de flores de H. tiliaceus apresentou atividade antidepressiva-like nos testes de nado forçado e de suspensão da cauda, ambos são amplamente usados como modelos animais preditivos da atividade antidepressiva. Além disso, o extrato demonstrou uma tendência de aumento do tempo gasto nos braços abertos no labirinto em cruz elevado. Considerando que o extrato de H. tiliaceus, que contém fitoesteróis como o estigmasterol, o stigmastadienol e o stigmastadienone, pode ser útil no tratamento ou prevenção da depressão pós-parto relacionadas à retirada crônica de altos níveis de hormônios associados à gestação. Nosso objetivo foi avaliar o efeito de extratos de H. tiliaceus em modelo animal de depressão pós-parto e ansiedade. Utilizamos ratas Wistar fêmeas submetidas ao modelo de depressão pós-parto induzido por hormônios (estradiol e progesterona), administrados por via subcutânea. Após período gestacional induzido, os animais receberam água, veiculo ou extrato de H. tiliaceus nas doses de 100 e 400mg/kg, via oral (gavagem). No período pós-parto, as ratas foram submetidas a testes comportamentais de nado forçado, o labirinto em cruz elevado e de preferência claro-escuro como modelos preditivo de depressão e ansiedade. Foi obsevado um aumento no tempo de imobilidade associado a uma diminuição na tentativa de fuga, no teste do nado forçado, em animais submetidos ao modelo de depressão pós-parto comparado ao grupo controle, sugerindo que este modelo é capaz reproduzir sintomas de depressão pós-parto. Não houve diferença significativa nos testes de ansiedade entre os animais submetidos ao modelo de depressão pós-parto comparado aos controles. A administração de extrato metanólico de H. tiliaceus não foi capaz de alterar o comportamento relacionado à depressão e ansiedade em ratas Wistar.

Postpartum affective disorders are rarely modeled. The depressive-like behavior of hormone withdrawal following hormone-simulated "pregnancy" was described in Long-Evans and Sprague Dawley rats. Our aim was to evaluate the validity of hormone withdrawal following hormonesimulated "pregnancy" method in Wistar rats as a model of depression and/or anxiety. Recently, it was demonstrated an antidepressant-like profile of methanol extract of Hibiscus tiliaceus L., a plant used in postpartum disorders, in adult male Swiss albino mice, then, we also investigated the antidepressant and anxiolytic-like activities of the methanol extract of H. tiliaceus flowers using this animal model of postpartum disorder. Ovariectomized rats received daily injections of the vehicle or hormones (estradiol and progesterone) to simulate the 23-day gestational period in the rat. Days 24-27 were considered the ''post-partum'' period, where the methanolic extract of H. tiliaceus or vehicle were administered by gavage. Rats were submitted to forced swimming, elevated plus-maze test and lightdark box tests. Rats submitted to ''post-partum depression model'' increased the…

Advisors/Committee Members: Siqueira, Ionara Rodrigues.

Subjects/Keywords: Hibiscus; Estradiol; Progesterona; Período pós-parto; Gravidez; Depressão; Reprodutibilidade dos testes; Estradiol; Progesterone; Post-partum; Pregnancy; Depression; Forced swimming test; Elevated plus-maze test; Light-dark box test

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Almeida, E. F. d. (2012). Efeito antidepressivo e ansiolítico do extrato metanólico de Hibiscus tiliaceus em modelo animal de depressão pós-parto. (Masters Thesis). Brazil. Retrieved from http://hdl.handle.net/10183/67656

Chicago Manual of Style (16^th Edition):

Almeida, Eduardo Farina de. “Efeito antidepressivo e ansiolítico do extrato metanólico de Hibiscus tiliaceus em modelo animal de depressão pós-parto.” 2012. Masters Thesis, Brazil. Accessed April 10, 2021. http://hdl.handle.net/10183/67656.

MLA Handbook (7^th Edition):

Almeida, Eduardo Farina de. “Efeito antidepressivo e ansiolítico do extrato metanólico de Hibiscus tiliaceus em modelo animal de depressão pós-parto.” 2012. Web. 10 Apr 2021.

Vancouver:

Almeida EFd. Efeito antidepressivo e ansiolítico do extrato metanólico de Hibiscus tiliaceus em modelo animal de depressão pós-parto. [Internet] [Masters thesis]. Brazil; 2012. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/10183/67656.

Council of Science Editors:

Almeida EFd. Efeito antidepressivo e ansiolítico do extrato metanólico de Hibiscus tiliaceus em modelo animal de depressão pós-parto. [Masters Thesis]. Brazil; 2012. Available from: http://hdl.handle.net/10183/67656

Texas A&M University

14. Bernhardt, Michelle Lee. 2008 Midwest Levee Failure: Erosion Studies.

Degree: MS, Civil Engineering, 2011, Texas A&M University

URL: http://hdl.handle.net/1969.1/ETD-TAMU-2009-12-7423

► The United States contains an estimated 100,000 miles (160000 km) of levees in which erosion related issues are the top priorities. Proper documentation of overtopping… (more)

▼ The United States contains an estimated 100,000 miles (160000 km) of levees in which erosion related issues are the top priorities. Proper documentation of overtopping induced erosion is a complicated issue involving the collection and analysis of timesensitive field data and personal observations. This thesis is a study of the performance of the Midwest Levee system during the 2008 flooding events. The goal of the Midwest Levee investigation was to gather and analyze perishable data in an effort to provide a comprehensive overview at each breach location. To predict how a site will perform during a particular flood event, there are three main inputs: the flood conditions, the site conditions, and the soil properties. Site geometry and imperfections can greatly affect the performance of a levee system. Any low spots or potential seepage paths can concentrate the flow and be detrimental to the levee. The vegetative cover is the single most important condition at a site. As seen in the Brevator case, vegetative armor can prevent failure of a levee comprised of less resistant soils subjected to long periods of overtopping. Recommended grasses include: Switchgrass, Smooth Brome, Reed Canarygrass, and Tall Fescue. It is also recommended that grasses are kept at least 0.5 m tall during the flood season and to limit the presence of trees to 10 m beyond the levee toe. The erosion resistance of the materials comprising the levee is also important. From the correlations in this study, it was determined that erodibility is influenced by grain size, relative compaction, clay content, and activity. Devices like the Torvane and Pocket Erodometer can also be used to get a quick field estimate of erosion. While these correlations and field devices give insight into an erodibility value, they are no substitute for site specific analysis with laboratory equipment such as the Erosion Function Apparatus. Soil behavior is highly nonlinear and the entire erosion function is needed to get an accurate measure of the erodibility of a soil. By combining these properties in an erosion matrix, a prediction of whether a site will withstand a given flood event can be made. Advisors/Committee Members: Briaud, Jean-Louis (advisor), Biscontin, Giovanna (advisor), Jessup, Russell W. (committee member).

Subjects/Keywords: Erosion; Erosion Function Apparatus; Levee; Midwest Levees; Vegetative cover; Pocket Erodometer Test

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bernhardt, M. L. (2011). 2008 Midwest Levee Failure: Erosion Studies. (Masters Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/ETD-TAMU-2009-12-7423

Chicago Manual of Style (16^th Edition):

Bernhardt, Michelle Lee. “2008 Midwest Levee Failure: Erosion Studies.” 2011. Masters Thesis, Texas A&M University. Accessed April 10, 2021. http://hdl.handle.net/1969.1/ETD-TAMU-2009-12-7423.

MLA Handbook (7^th Edition):

Bernhardt, Michelle Lee. “2008 Midwest Levee Failure: Erosion Studies.” 2011. Web. 10 Apr 2021.

Vancouver:

Bernhardt ML. 2008 Midwest Levee Failure: Erosion Studies. [Internet] [Masters thesis]. Texas A&M University; 2011. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2009-12-7423.

Council of Science Editors:

Bernhardt ML. 2008 Midwest Levee Failure: Erosion Studies. [Masters Thesis]. Texas A&M University; 2011. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2009-12-7423

University of South Africa

15. Laisi, Elton. Development of a flood-frequency model for the river basins of the Central Region of Malawi as a tool for engineering design and disaster preparedness in flood-prone areas .

Degree: 2016, University of South Africa

URL: http://hdl.handle.net/10500/23597

► Since 1971, a number of flood frequency models have been developed for river basins in Malawi for use in the design of hydraulic structures, but… (more)

Subjects/Keywords: Flood frequency; Homogeneity test; Hydraulic structures; Land use and land cover change; Return period

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Laisi, E. (2016). Development of a flood-frequency model for the river basins of the Central Region of Malawi as a tool for engineering design and disaster preparedness in flood-prone areas . (Masters Thesis). University of South Africa. Retrieved from http://hdl.handle.net/10500/23597

Chicago Manual of Style (16^th Edition):

Laisi, Elton. “Development of a flood-frequency model for the river basins of the Central Region of Malawi as a tool for engineering design and disaster preparedness in flood-prone areas .” 2016. Masters Thesis, University of South Africa. Accessed April 10, 2021. http://hdl.handle.net/10500/23597.

MLA Handbook (7^th Edition):

Laisi, Elton. “Development of a flood-frequency model for the river basins of the Central Region of Malawi as a tool for engineering design and disaster preparedness in flood-prone areas .” 2016. Web. 10 Apr 2021.

Vancouver:

Laisi E. Development of a flood-frequency model for the river basins of the Central Region of Malawi as a tool for engineering design and disaster preparedness in flood-prone areas . [Internet] [Masters thesis]. University of South Africa; 2016. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/10500/23597.

Council of Science Editors:

Laisi E. Development of a flood-frequency model for the river basins of the Central Region of Malawi as a tool for engineering design and disaster preparedness in flood-prone areas . [Masters Thesis]. University of South Africa; 2016. Available from: http://hdl.handle.net/10500/23597

Universidade Nova

16. Costa, Helder António Bento da. Detecting and evaluating land cover change in the eastern half of East Timor (1972-2011).

Degree: 2013, Universidade Nova

URL: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/9204

►

Dissertation submitted in partial fulfillment of the requirements for the Degree of Master of Science in Geospatial Technologies.

Land use / land cover (LULC) change… (more)

▼

Dissertation submitted in partial fulfillment of the requirements for the Degree of Master of Science in Geospatial Technologies.

Land use / land cover (LULC) change detection based on remote sensing (RS) data is an important source of information for various decision support systems. In East Timor where forest plays a key role in sustaining communities’ livelihoods the information derived from LULC change detection is invaluable to the conservation, sustainable development and management of forest resources. To assess the patterns of land cover change, as a result of complex socio-economic factors, satellite imagery and image processing techniques can be useful. This study is concerned with identifying change in land use and land cover types in East Timor between 1972 and 2011, using satellite images from Landsat MSS, TM and ETM+ sensors. Seven major cover types were identified in this study including forest, mixed rangeland, grassland, farmland, built-up areas, bare soil and water. A combination of NDVI differencing, supervised and unsupervised classification was used to derive final classification maps. Due to the lack of ground truth data, further processing were performed to improve the final classification maps by applying rationality change test. Post-classification comparison change detection technique was used to assess categorical changes between 1972 and 2011. The results highlight a significant level of deforestation due to uncontrolled illegal logging and increase in farmland, built-up areas, as well as bare soil. This decline has had considerable impact on the livelihoods of rural communities. As the new nation of Timor-Leste establishes itself, it must consider its current stock and distribution of natural resources to ensure that development efforts are geared towards sustainable outcomes. Without this information historical patterns of resource consumption, development efforts may, unwittingly, lead to continuing decline in forest resources.

Advisors/Committee Members: Caetano, Mário Rochinha de Andrade, Bañon, Filiberto Pla, Pebesma, Edzer.

Subjects/Keywords: Change Detection; Change Rationality Test; Landsat; Land Use; Land Cover; NDVI Differencing

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APA (6^th Edition):

Costa, H. A. B. d. (2013). Detecting and evaluating land cover change in the eastern half of East Timor (1972-2011). (Thesis). Universidade Nova. Retrieved from http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/9204

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Costa, Helder António Bento da. “Detecting and evaluating land cover change in the eastern half of East Timor (1972-2011).” 2013. Thesis, Universidade Nova. Accessed April 10, 2021. http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/9204.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Costa, Helder António Bento da. “Detecting and evaluating land cover change in the eastern half of East Timor (1972-2011).” 2013. Web. 10 Apr 2021.

Vancouver:

Costa HABd. Detecting and evaluating land cover change in the eastern half of East Timor (1972-2011). [Internet] [Thesis]. Universidade Nova; 2013. [cited 2021 Apr 10]. Available from: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/9204.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Costa HABd. Detecting and evaluating land cover change in the eastern half of East Timor (1972-2011). [Thesis]. Universidade Nova; 2013. Available from: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/9204

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

17. 박, 아람. Clinical Efficacy of Photography with Spielmann Translucent Occluder in Intermittent Exotropia.

Degree: 2019, Ajou University

URL: http://repository.ajou.ac.kr/handle/201003/17876 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000028662

►

This study was to evaluate clinical efficacy of photography with Spielmann translucent occluder in intermittent exotropia. A total of 271 patients with intermittent exotropia were… (more)

▼

This study was to evaluate clinical efficacy of photography with Spielmann translucent occluder in intermittent exotropia. A total of 271 patients with intermittent exotropia were included. Photographs were obtained in alternate cover test with Spielmann translucent occluder, and analyzed by 3 observers (2 strabismus pediatric ophthalmology specialists and 1 ophthalmology resident). The angle of photo-analysis was compared with that of prism alternate cover test. We also measured inter-observer variability and the effect of the type of exotropia, the direction of suppression, eyelid features and control grade. Photo-analysis and prism alternate cover test showed a strong positive correlation (at distant R=0.605, at near R=0.531; P <0.001), and the standard error was 3.6 prism diopter (PD). The standard error in inter-observer difference was 3.3PD (ICC=0.786; P <0.001). In basic type of intermittent exotropia, there was positive correlation between the angle of photoanalysis and that of prism alternate cover test, while no correlation in convergence insufficiency type and divergence excess type. The angle of deviation in photo analysis was lower than that of prism alternate cover test in patient who have good control grade, but not statistically significant. There was no difference according to the direction of suppression. Photography with Spielmann translucent occluder can be used as an objective tool for measuring the angle of exotropia deviation. However, there is possibility of errors according to the degree and type of exotropia and control grade.

반투명가리개를 이용하여 간헐외사시를 촬영한 사진의 유용성을 평가하고자 하였다. 간헐외사시 환자 271명을 대상으로 Spielmann반투명가리개를 이용하여 한눈씩 교대로 가리면서 정면사진을 촬영하였다. 사진에서 보이는 사시각을 안과의사 3명이 표준사진을 바탕으로 판독하여 프리즘교대가림검사로 측정한 사시각과 비교하였다. 검사방법간, 검사자간 차이를 분석하였고, 간헐외사시의 종류, 억제, 눈꺼풀모양, 조절정도가 사진촬영에 영향을 미치는지 조사하였다. 사진 사시각은 실제 사시각과 뚜렷한 양의 상관관계가 있었고(원거리 R=0.605, 근거리 R=0.531, P <0.001), 3.6프리즘디옵터(PD)의 표준오차를 보였다. 사진 사시각의 검사자간 표준오차는 3.3PD이었다(ICC=0.786, P <0.001). 기본형에서는 사진 사시각이 실제 사시각을 반영하였지만, 눈모음부족형과 눈벌림과다형에서는 상관관계가 없었다. 조절정도가 좋은 환자에서 사진 사시각이 실제 사시각보다 적은 경향이 있었으나, 억제유무와 방향에 따른 차이는 없었다. 간헐외사시에서 반투명가리개를 이용하여 촬영한 사진 사시각은 실제 사시각을 비교적 반영하였지만, 사시 정도와 종류, 조절정도에 따른 영향이 있을 수 있으므로 해석에 주의하여야 하겠다.

Ⅰ. 서론 1 Ⅱ. 연구대상 및 방법 2 Ⅲ. 결과 7 Ⅳ. 고찰 21 Ⅴ. 결론 25 참고문헌 26 ABSTRACT 27

Master

Advisors/Committee Members: 대학원 의학과, 201524487, 박, 아람.

Subjects/Keywords: Intermittent exotropia; Strabismic angle; Spielmann translucent occluder; Prism alternate cover test; 간헐외사시; 사시각; 반투명가리개; 프리즘교대가림검사

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

박, �. (2019). Clinical Efficacy of Photography with Spielmann Translucent Occluder in Intermittent Exotropia. (Thesis). Ajou University. Retrieved from http://repository.ajou.ac.kr/handle/201003/17876 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000028662

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

박, 아람. “Clinical Efficacy of Photography with Spielmann Translucent Occluder in Intermittent Exotropia.” 2019. Thesis, Ajou University. Accessed April 10, 2021. http://repository.ajou.ac.kr/handle/201003/17876 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000028662.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

박, 아람. “Clinical Efficacy of Photography with Spielmann Translucent Occluder in Intermittent Exotropia.” 2019. Web. 10 Apr 2021.

Vancouver:

박 �. Clinical Efficacy of Photography with Spielmann Translucent Occluder in Intermittent Exotropia. [Internet] [Thesis]. Ajou University; 2019. [cited 2021 Apr 10]. Available from: http://repository.ajou.ac.kr/handle/201003/17876 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000028662.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

박 �. Clinical Efficacy of Photography with Spielmann Translucent Occluder in Intermittent Exotropia. [Thesis]. Ajou University; 2019. Available from: http://repository.ajou.ac.kr/handle/201003/17876 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000028662

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Toronto

18. Karam, Majed. Assessing the Impact of Curing on Chloride Penetration Resistance of the Concrete Cover Zone.

Degree: 2020, University of Toronto

URL: http://hdl.handle.net/1807/103218

►

There is a lack of rapid test methods for accurately assessing the impact of curing on the differential hydration through the depth of the concrete… (more)

Subjects/Keywords: Chloride Penetration; Concrete Cover; Differential Hydration; Electrical Resistivity; Performance Test; Sorptivity; 0543

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Karam, M. (2020). Assessing the Impact of Curing on Chloride Penetration Resistance of the Concrete Cover Zone. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/103218

Chicago Manual of Style (16^th Edition):

Karam, Majed. “Assessing the Impact of Curing on Chloride Penetration Resistance of the Concrete Cover Zone.” 2020. Masters Thesis, University of Toronto. Accessed April 10, 2021. http://hdl.handle.net/1807/103218.

MLA Handbook (7^th Edition):

Karam, Majed. “Assessing the Impact of Curing on Chloride Penetration Resistance of the Concrete Cover Zone.” 2020. Web. 10 Apr 2021.

Vancouver:

Karam M. Assessing the Impact of Curing on Chloride Penetration Resistance of the Concrete Cover Zone. [Internet] [Masters thesis]. University of Toronto; 2020. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/1807/103218.

Council of Science Editors:

Karam M. Assessing the Impact of Curing on Chloride Penetration Resistance of the Concrete Cover Zone. [Masters Thesis]. University of Toronto; 2020. Available from: http://hdl.handle.net/1807/103218

New Jersey Institute of Technology

19. Rajah, Joel V. Vergence eye movement parameters for pre/post-obvat and sham therapy on binocularly normal controls.

Degree: MSin Biomedical Engineering - (M.S.), Biomedical Engineering, 2019, New Jersey Institute of Technology

URL: https://digitalcommons.njit.edu/theses/1659

► Vergence is the disjunctive movement of the eyes to maintain single binocular vision. Vergence eye movements are necessary to maintain the object of interest… (more)

Subjects/Keywords: Vergence; Vergence eye movement; Convergence insufficiency; Biomedical Engineering and Bioengineering

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APA (6^th Edition):

Rajah, J. V. (2019). Vergence eye movement parameters for pre/post-obvat and sham therapy on binocularly normal controls. (Thesis). New Jersey Institute of Technology. Retrieved from https://digitalcommons.njit.edu/theses/1659

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rajah, Joel V. “Vergence eye movement parameters for pre/post-obvat and sham therapy on binocularly normal controls.” 2019. Thesis, New Jersey Institute of Technology. Accessed April 10, 2021. https://digitalcommons.njit.edu/theses/1659.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rajah, Joel V. “Vergence eye movement parameters for pre/post-obvat and sham therapy on binocularly normal controls.” 2019. Web. 10 Apr 2021.

Vancouver:

Rajah JV. Vergence eye movement parameters for pre/post-obvat and sham therapy on binocularly normal controls. [Internet] [Thesis]. New Jersey Institute of Technology; 2019. [cited 2021 Apr 10]. Available from: https://digitalcommons.njit.edu/theses/1659.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rajah JV. Vergence eye movement parameters for pre/post-obvat and sham therapy on binocularly normal controls. [Thesis]. New Jersey Institute of Technology; 2019. Available from: https://digitalcommons.njit.edu/theses/1659

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Norte

20. Melo, Thieza Graziella Araújo da Silva Góes de. Antidepressivos modificam a extinção de uma memória aversiva em ratas .

Degree: 2011, Universidade do Rio Grande do Norte

URL: http://repositorio.ufrn.br/handle/123456789/17314

► Treatment of major depression, posttraumatic stress disorder and other psychopathologies with antidepressants can be associated with improvement of the cognitive deficits related to these disorders.… (more)

Subjects/Keywords: Fluoxetina; Nortriptilina; Mirtazapina; Ratas; Memória aversiva; Depressão; Ansiedade; Discriminative avoidance task; Sex differences; Forced swimming test; Aversive memory; Depression; Anxiety

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APA (6^th Edition):

Melo, T. G. A. d. S. G. d. (2011). Antidepressivos modificam a extinção de uma memória aversiva em ratas . (Thesis). Universidade do Rio Grande do Norte. Retrieved from http://repositorio.ufrn.br/handle/123456789/17314

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Melo, Thieza Graziella Araújo da Silva Góes de. “Antidepressivos modificam a extinção de uma memória aversiva em ratas .” 2011. Thesis, Universidade do Rio Grande do Norte. Accessed April 10, 2021. http://repositorio.ufrn.br/handle/123456789/17314.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Melo, Thieza Graziella Araújo da Silva Góes de. “Antidepressivos modificam a extinção de uma memória aversiva em ratas .” 2011. Web. 10 Apr 2021.

Vancouver:

Melo TGAdSGd. Antidepressivos modificam a extinção de uma memória aversiva em ratas . [Internet] [Thesis]. Universidade do Rio Grande do Norte; 2011. [cited 2021 Apr 10]. Available from: http://repositorio.ufrn.br/handle/123456789/17314.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Melo TGAdSGd. Antidepressivos modificam a extinção de uma memória aversiva em ratas . [Thesis]. Universidade do Rio Grande do Norte; 2011. Available from: http://repositorio.ufrn.br/handle/123456789/17314

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

21. Lim, Sher-Wei. Therapeutic evaluation of simvastatin and hyperbaric oxygen in neurotrauma related depression.

Degree: PhD, Institute of Biomedical Sciences, 2018, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0316118-210041

► Introduction Previous researches showed that depression is the most frequently diagnosed psychiatric disorder after traumatic brain injury (TBI). Neuroinflammation plays an important role in this… (more)

▼ Introduction Previous researches showed that depression is the most frequently diagnosed psychiatric disorder after traumatic brain injury (TBI). Neuroinflammation plays an important role in this issue. Our previous study demonstrated that hyperbaric oxygen (HBO) therapy in after TBI can attenuate neuroinflammation, resulting in a neuroprotective effect. We also found preexisting hyperlipidemia to be an independent predictor of new-onset depression and anxiety in patients with TBI. In this thesis, in the basic research, we will elucidate the therapeutic effect of HBO and Simvastatin in acute stage of TBI-induced anti-depression-like behavior by rat model. In addition to TBI, psychological disorders may also occur after traumatic spinal cord injury (tSCI). Therefore, in the clinical research, we conducted a large nationwide Taiwanese population-based study to retrospectively examine the relationship between tSCI and the risk of new-onset anxiety or depression in comparison with other health condition groups. We also hypothesized that preexisting hyperlipidemia may also a risk factor for new-onset of anxiety and depression in patient with tSCI. Methods and results There are basic research and clinical research two parts in this study: Fluid percussion device was used in anesthetized rats to produce a moderate severity brain trauma. In the basic research I study, animals were divided into 3 groups: sham operation plus normobaric air (NBA), TBI plus NBA, and TBI plus HBO. HBO was applied immediately for 60min/d after TBI for 3 days. In the basic research II study, animals were divided into 5 groups: sham-operated controls, TBI controls, and TBI treatment with Simvastatin 4, 10, or 20mg/kg. Simvastatin was intraperitoneally injected 0, 24, and 48 hours after TBI. The motor function was measured using an inclined plane, and depression-like behavior was evaluated using forced swimming tests on the 4th, 8th, and 15th day after TBI in all groups. Neuronal apoptosis, microglia and astrocyte activation, and TNF-Î± expression in the microglia and astrocytes of the hippocampal CA3 area were investigated using immunofluorescence assay. TBI-induced depression-like behavior, which increased duration of immobility, was significant attenuated by HBO or 20mg Simvastatin therapy on day 15 after TBI. TBI-induced neuronal apoptosis, microglia and astrocyte activation, and TNF-Î± expression in the microglia and astrocytes of the CA3 area of the hippocampus were significant reduced by HBO or Simvastatin treatment, particularly when 20mg/kg was administered for 3 days. In the clinical research for tSCI, the Longitudinal Health Insurance Database (LHID) from Taiwanâs National Heath Insurance Research Database (NHIRD) was used for retrospective cohort study. Individuals with tSCI were identified using the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) diagnostic codes. The relative risk of anxiety or depression was estimated using a Cox regression analysis between patients with tSCI and health… Advisors/Committee Members: Chin-Hong Chang (chair), Jinn-Rung Kuo (committee member), Long-Sen Chang (chair), Che-Chuan Wang (chair), Yow-Ling Shiue (committee member), Chien-Feng Li (committee member), Chung-Ching Chio (chair).

Subjects/Keywords: TNF-Î±; neurotrauma; traumatic brain injury; traumatic spinal cord injury; depression; Simvastatin; hyperbaric oxygen; forced swimming test

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lim, S. (2018). Therapeutic evaluation of simvastatin and hyperbaric oxygen in neurotrauma related depression. (Doctoral Dissertation). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0316118-210041

Chicago Manual of Style (16^th Edition):

Lim, Sher-Wei. “Therapeutic evaluation of simvastatin and hyperbaric oxygen in neurotrauma related depression.” 2018. Doctoral Dissertation, NSYSU. Accessed April 10, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0316118-210041.

MLA Handbook (7^th Edition):

Lim, Sher-Wei. “Therapeutic evaluation of simvastatin and hyperbaric oxygen in neurotrauma related depression.” 2018. Web. 10 Apr 2021.

Vancouver:

Lim S. Therapeutic evaluation of simvastatin and hyperbaric oxygen in neurotrauma related depression. [Internet] [Doctoral dissertation]. NSYSU; 2018. [cited 2021 Apr 10]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0316118-210041.

Council of Science Editors:

Lim S. Therapeutic evaluation of simvastatin and hyperbaric oxygen in neurotrauma related depression. [Doctoral Dissertation]. NSYSU; 2018. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0316118-210041

Brigham Young University

22. Crossen, Edward Wayne. Textural, Color and Sensory Attributes of Fruits and Vegetables Dried Using Electric Forced-Air and Solar Dehydrators.

Degree: MS, 2017, Brigham Young University

URL: https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=7675&context=etd

► Direct sun drying is one of the oldest methods of food preservation. A drying method that utilizes solar energy while minimizing negative aspects of sun… (more)

Subjects/Keywords: solar dryer; forced-air dryer; dried fruits; dried vegetables; sensory; affective test; colorimeter; texture; apple; grape; tomato; carrot; pea; Nutrition

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Crossen, E. W. (2017). Textural, Color and Sensory Attributes of Fruits and Vegetables Dried Using Electric Forced-Air and Solar Dehydrators. (Masters Thesis). Brigham Young University. Retrieved from https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=7675&context=etd

Chicago Manual of Style (16^th Edition):

Crossen, Edward Wayne. “Textural, Color and Sensory Attributes of Fruits and Vegetables Dried Using Electric Forced-Air and Solar Dehydrators.” 2017. Masters Thesis, Brigham Young University. Accessed April 10, 2021. https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=7675&context=etd.

MLA Handbook (7^th Edition):

Crossen, Edward Wayne. “Textural, Color and Sensory Attributes of Fruits and Vegetables Dried Using Electric Forced-Air and Solar Dehydrators.” 2017. Web. 10 Apr 2021.

Vancouver:

Crossen EW. Textural, Color and Sensory Attributes of Fruits and Vegetables Dried Using Electric Forced-Air and Solar Dehydrators. [Internet] [Masters thesis]. Brigham Young University; 2017. [cited 2021 Apr 10]. Available from: https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=7675&context=etd.

Council of Science Editors:

Crossen EW. Textural, Color and Sensory Attributes of Fruits and Vegetables Dried Using Electric Forced-Air and Solar Dehydrators. [Masters Thesis]. Brigham Young University; 2017. Available from: https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=7675&context=etd

23. Jonsson, Josefine. Effect of voluntary exercise on BDNF/TrkB gene expression and alcohol intake.

Degree: The Institute of Technology, 2012, Linköping UniversityLinköping University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-86749

► Voluntary wheel running is rewarding and believed to activate the same brain reward system as in alcohol and drug addiction. Brain-derived neurotrophic factor (BDNF),… (more)

Subjects/Keywords: Alcohol addiction; BDNF; C57BL/6 mice; Forced swim test; Gene expression; Neurotrophins; TrkB; Voluntary wheel exercise

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APA (6^th Edition):

Jonsson, J. (2012). Effect of voluntary exercise on BDNF/TrkB gene expression and alcohol intake. (Thesis). Linköping UniversityLinköping University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-86749

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jonsson, Josefine. “Effect of voluntary exercise on BDNF/TrkB gene expression and alcohol intake.” 2012. Thesis, Linköping UniversityLinköping University. Accessed April 10, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-86749.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jonsson, Josefine. “Effect of voluntary exercise on BDNF/TrkB gene expression and alcohol intake.” 2012. Web. 10 Apr 2021.

Vancouver:

Jonsson J. Effect of voluntary exercise on BDNF/TrkB gene expression and alcohol intake. [Internet] [Thesis]. Linköping UniversityLinköping University; 2012. [cited 2021 Apr 10]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-86749.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jonsson J. Effect of voluntary exercise on BDNF/TrkB gene expression and alcohol intake. [Thesis]. Linköping UniversityLinköping University; 2012. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-86749

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

24. Freitas, Daniele Leão de. Influência da estimulação tátil neonatal associada à administração de antidepressivo, sobre parâmetros comportamentais e bioquímicos em ratos jovens.

Degree: 2017, Universidade Federal de Santa Maria; Centro de Ciências Naturais e Exatas; Programa de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica; UFSM; Brasil; Ciências Biológicas

URL: http://repositorio.ufsm.br/handle/1/12430

►

Early life events, in both humans and animals, may influence on brain development, leading to long-term consequences on adult behavior. Thus, this study was carried… (more)

▼

Early life events, in both humans and animals, may influence on brain development, leading to long-term consequences on adult behavior. Thus, this study was carried out in order to assess the influence of neonatal tactile stimulation (TS), when associated to sub-therapeutic administration of sertraline (SERT) in rats, on behavioral parameters related to depression-like. We also evaluated the influence of the TS-SERT association on the hypothalamic-pituitary-adrenal axis, as well as on the development of anxiety-like symptoms, assessed in different behavioral. Male rat pups were daily submitted to 10 min TS, from postnatal day (PND) 8 to PND 14. On DPN50, rats were first exposed to forced swimming test (FST). Then, after 24h, it was conducted the SERT administration and, 30 minutes later, animals were submitted to new evaluation on FST. On DPN51, rats were evaluated on the elevated plus maze (EPM). The animals were euthanized 24h after the behavioral tasks, followed by biochemical assessments. TS per se decreased depression behaviors, since there was an increase on swimming time and a decrease on immobility time in FST. On the EPM task, TS diminished behaviors related to anxiety, as shown in the increase of time on open arms and decrease on anxiety rates. In addition, TS also decreased corticosterone and cortisol plasma levels. All these results were enhanced when TS was associated to a sub-therapeutic dose of SERT. From these results, we suggest that neonatal handling TS may accomplish beneficial influence on parameters of depression, promoting the ability to cope with stressful situations in adulthood.

Eventos ocorridos em estágios iniciais do desenvolvimento, tanto em humanos quanto em animais, influenciam o desenvolvimento do cérebro e podem ter consequências em longo prazo na idade adulta. Assim, o presente estudo foi realizado para avaliar a influência da estimulação tátil neonatal (ET), associada à administração de uma dose subterapêutica de sertralina (SERT), sobre parâmetros comportamentais relacionados a depressão em ratos. A influência da associação ET-SERT sobre o eixo hipotálamo-pituitária-adrenal, assim como sobre o desenvolvimento de comportamentos de ansiedade foram também avaliados. Filhotes machos de ratos Wistar foram diariamente submetidos à ET durante 10 min, desde o dia pós-natal (DPN) 8 até o DPN14. No DPN50, os animais foram previamente expostos ao nado forçado. Após 24h, receberam a administração de SERT e, decorridos 30 minutos, foram novamente avaliados mediante o estresse do nado forçado. No DPN 51, os animais também foram avaliados no labirinto em cruz elevado (LCE). Os animais foram eutanasiados 24h após os testes comportamentais, seguindo-se as avaliações bioquímicas. A ET per se reduziu comportamentos de depressão, tendo em vista a observação do maior tempo de nado e menor tempo de imobilidade no teste do nado forçado. No teste do LCE, a ET diminuiu comportamentos relacionados à ansiedade, como observado pelo maior tempo nos braços abertos e pelo menor índice de ansiedade. Além…

Advisors/Committee Members: Burger, Marilise Escobar, Brüning, César Augusto, Pase, Camila Simonetti.

Subjects/Keywords: Manipulação neonatal; Nado forçado; Sertralina; Ansiedade; Estresse; Neonatal handling; Forced swimming test; Sertraline; Anxiety; Stress; CNPQ::CIENCIAS BIOLOGICAS

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Freitas, D. L. d. (2017). Influência da estimulação tátil neonatal associada à administração de antidepressivo, sobre parâmetros comportamentais e bioquímicos em ratos jovens. (Masters Thesis). Universidade Federal de Santa Maria; Centro de Ciências Naturais e Exatas; Programa de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica; UFSM; Brasil; Ciências Biológicas. Retrieved from http://repositorio.ufsm.br/handle/1/12430

Chicago Manual of Style (16^th Edition):

Freitas, Daniele Leão de. “Influência da estimulação tátil neonatal associada à administração de antidepressivo, sobre parâmetros comportamentais e bioquímicos em ratos jovens.” 2017. Masters Thesis, Universidade Federal de Santa Maria; Centro de Ciências Naturais e Exatas; Programa de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica; UFSM; Brasil; Ciências Biológicas. Accessed April 10, 2021. http://repositorio.ufsm.br/handle/1/12430.

MLA Handbook (7^th Edition):

Freitas, Daniele Leão de. “Influência da estimulação tátil neonatal associada à administração de antidepressivo, sobre parâmetros comportamentais e bioquímicos em ratos jovens.” 2017. Web. 10 Apr 2021.

Vancouver:

Freitas DLd. Influência da estimulação tátil neonatal associada à administração de antidepressivo, sobre parâmetros comportamentais e bioquímicos em ratos jovens. [Internet] [Masters thesis]. Universidade Federal de Santa Maria; Centro de Ciências Naturais e Exatas; Programa de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica; UFSM; Brasil; Ciências Biológicas; 2017. [cited 2021 Apr 10]. Available from: http://repositorio.ufsm.br/handle/1/12430.

Council of Science Editors:

Freitas DLd. Influência da estimulação tátil neonatal associada à administração de antidepressivo, sobre parâmetros comportamentais e bioquímicos em ratos jovens. [Masters Thesis]. Universidade Federal de Santa Maria; Centro de Ciências Naturais e Exatas; Programa de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica; UFSM; Brasil; Ciências Biológicas; 2017. Available from: http://repositorio.ufsm.br/handle/1/12430

25. Carvalho, Bernardo Hollanda de. Investigação do mecanismo de ação antidepressivo-símile da quercetina em camundongos por meio de testes comportamentais e neuroquímicos.

Degree: 2018, Universidade Federal da Paraíba; Programa de Pós-Graduação em Neurociência Cognitiva e Comportamento; UFPB; Brasil; Psicologia Social

URL: https://repositorio.ufpb.br/jspui/handle/123456789/14867

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Nenhuma

A depressão é um transtorno psiquiátrico com alta incidência na população. O tratamento envolve fármacos que possuem uma série de efeitos adversos que, em muitos casos, diminuem a adesão do paciente ao tratamento. Isto tem incentivado a busca por novos fármacos e o reino vegetal se apresenta como uma alternativa. Os flavonoides são uma classe de metabólitos secundários encontrados em diferentes espécies de plantas. A quercetina (3, 5, 7, 3’ – 4’ pentahidroxi flavona), um importante flavonoide, possui diversas atividades biológicas, entre elas: atividade anti-inflamatória, anti-agregante, anti-hipertensiva, antidiabética, ansiolítica e antidepressiva. Esta última atividade, no entanto, ainda não é bem caracterizada e este fato levou ao desenvolvimento do presente trabalho, o qual teve como objetivo avaliar o efeito antidepressivo-símile da quercetina, por meio de testes comportamentais e neuroquímicos. Foram utilizados camundongos Swiss machos (protocolo CEUA/UFPB n. 112/2016), provenientes da Unidade de Produção Animal da Universidade Federal da Paraíba – UPA/UFPB. Os animais foram divididos em grupos compostos por seis camundongos, tratados por via oral com salina, quercetina 10 ou 40 mg/kg e por via intraperitoneal com imipramina 30 mg/kg, e submetidos aos testes do campo aberto e nado forçado. Para investigação do possível mecanismo de ação, a quercetina foi administrada isoladamente (0,5 mg/kg, v.o.) e em associação aos antidepressivos bupropiona (0,1 mg/kg, i.p.), fluoxetina (0,1 mg/kg, i.p.) ou imipramina (1 mg/kg, i.p.) em animais submetidos ao nado forçado. Em adição foram realizadas análises neuroquímicas para determinar a concentração estriatal de monoaminas e a concentração hipocampal de nitrito e TBARs. Os resultados mostraram que a quercetina não alterou a atividade locomotora no teste do campo aberto; por outro lado, o composto reduziu de forma significativa e dose-dependente o tempo de imobilidade dos animais no nado forçado. Este efeito foi potencializado na presença de bupropiona e imipramina, mas não de fluoxetina. A quercetina (10 mg/kg, v.o.) não alterou a concentração hipocampal de nitrito e TBARs; por outro lado, o composto aumentou significativamente a concentração de noradrenalina, mas não de dopamina, no estriado de animais submetidos ao teste do nado forçado. Tomados em conjunto, os resultados sugerem que o efeito antidepressivo-símile da quercetina parece depender, pelo menos em parte, do aumento da concentração estriatal de monoaminas, em especial, a…

Advisors/Committee Members: Felipe, Cícero Francisco Bezerra.

Subjects/Keywords: CNPQ::CIENCIAS HUMANAS::PSICOLOGIA; Depressão; Nado forçado; Flavonóides; Quercetina; Monoaminas; Estresse oxidativo; Depression; Forced swim test; Flavonoids; Quercetin; Monoamines; Oxidative stress

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Carvalho, B. H. d. (2018). Investigação do mecanismo de ação antidepressivo-símile da quercetina em camundongos por meio de testes comportamentais e neuroquímicos. (Masters Thesis). Universidade Federal da Paraíba; Programa de Pós-Graduação em Neurociência Cognitiva e Comportamento; UFPB; Brasil; Psicologia Social. Retrieved from https://repositorio.ufpb.br/jspui/handle/123456789/14867

Chicago Manual of Style (16^th Edition):

Carvalho, Bernardo Hollanda de. “Investigação do mecanismo de ação antidepressivo-símile da quercetina em camundongos por meio de testes comportamentais e neuroquímicos.” 2018. Masters Thesis, Universidade Federal da Paraíba; Programa de Pós-Graduação em Neurociência Cognitiva e Comportamento; UFPB; Brasil; Psicologia Social. Accessed April 10, 2021. https://repositorio.ufpb.br/jspui/handle/123456789/14867.

MLA Handbook (7^th Edition):

Carvalho, Bernardo Hollanda de. “Investigação do mecanismo de ação antidepressivo-símile da quercetina em camundongos por meio de testes comportamentais e neuroquímicos.” 2018. Web. 10 Apr 2021.

Vancouver:

Carvalho BHd. Investigação do mecanismo de ação antidepressivo-símile da quercetina em camundongos por meio de testes comportamentais e neuroquímicos. [Internet] [Masters thesis]. Universidade Federal da Paraíba; Programa de Pós-Graduação em Neurociência Cognitiva e Comportamento; UFPB; Brasil; Psicologia Social; 2018. [cited 2021 Apr 10]. Available from: https://repositorio.ufpb.br/jspui/handle/123456789/14867.

Council of Science Editors:

Carvalho BHd. Investigação do mecanismo de ação antidepressivo-símile da quercetina em camundongos por meio de testes comportamentais e neuroquímicos. [Masters Thesis]. Universidade Federal da Paraíba; Programa de Pós-Graduação em Neurociência Cognitiva e Comportamento; UFPB; Brasil; Psicologia Social; 2018. Available from: https://repositorio.ufpb.br/jspui/handle/123456789/14867

26. Angélica Caroline Dutra Romano Suavinha. Participação da via BDNF-TRkB-mTor do córtex pré-frontal medial ventral no efeito tipo antidepressivo induzido por inibidores da metilação do DNA.

Degree: 2014, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/60/60138/tde-24062014-092102/

► Recentemente suspeitas de que mecanismos epigenéticos poderiam estar relacionados à fisiopatologia da depressão foram levantadas. Estudos recentes indicam que as alterações na transcrição gênica, induzidas… (more)

▼ Recentemente suspeitas de que mecanismos epigenéticos poderiam estar relacionados à fisiopatologia da depressão foram levantadas. Estudos recentes indicam que as alterações na transcrição gênica, induzidas por estresse ou por drogas antidepressivas, parecem envolver mecanismos epigenéticos. Nesse sentido, resultados preliminares de nosso grupo de pesquisa indicaram pioneiramente inibição global da metilação de DNA através da administração sistêmica do agente inibidor da DNA metiltransferase (DNMTs), 5-aza-2-deoxicitidina (5-azaD), induz efeito tipo-antidepressivo, dose-dependente, no modelo animal do nado forçado em ratos(Sales et al., 2011). O córtex pré-frontal medial ventral (CPFMv) é uma estrutura límbica intimamente relacionada com a neurobiologia da depressão. Evidências recentes indicam que o efeito tipo-antidepressivo aparece associado a aumento dos níveis da neurotrofina BDNF (brain derived neurotrophic factor) e de seu receptor TrkB no CPFMv, sendo a sinalização intracelular mediada pela ativação da proteína m-TOR. Contudo, não há evidências de que esses mecanismos moleculares estariam envolvidos nos efeitos induzidos pelos inibidores da metilação do DNA. Sabe-se, no entanto, que tanto o BDNF quanto TrkB têm sua expressão regulada por metilação do DNA. Diante disso, o objetivo presente trabalho será investigar a participação da via BDNF-TrkB-mTOR do CPFMv no efeito antidepressivo induzido por inibidores da metilação de DNA. Para tanto, ratos tratados com inibidores da metilação de DNA (5-azaD ou RG-108), em dois momentos diferentes (imediatamente após o PT e 23horas após o PT) foram submetidos ao teste do nado forçado (FST). Outro grupo de animais recebeu uma injeção intra-CPMv de k252a ou Rapamicina, 40 minutos antes do teste e uma injeção de BDNF intra-CPFMv, 30 minutos antes do teste. Em outro experimento, grupos independentes de animais submetidos ao nado forçado foram tratados sistemicamente com RG-108 e receberam injeção intra-CPFMv de K252a (antagonista de Trk) ou de rapamicina (inibidor da m-Tor), a fim de investigar se o efeito dessas drogas depende da via BDNF-TrkB-mTOR no CPFMv. Um grupo independente foi tratado com RG108 e CPFM desses animais foi dissecado para posterior análise da expressão de BDNF, TrkB e m-TOR, bem como da metilação de DNA. O tratamento com RG108 e 5azaD sistêmico reduziu o tempo de imobilidade dos animais submetidos ao nado forçado nos dois tempo de administração. A administração intra-CPFMv de BDNF promoveu efeito antidepressivo no FST, e esse efeito foi bloqueado pela administração de k252a ou Rapamicina no CPFMv. No mesmo sentido, o efeito antidepressivo do RG108 sistêmico foi bloqueado pela administração intra-CPFMv de k252a ou Rapamicina. Entretanto, a medida dos níveis de metilação global no CPFMv não apresentou alteração como tratamento com RG108, e também não mostrou alteração nos níveis de BDNF presente no CPF. O tratamento com RG108 não alterou a expressão, bem como a ativação de TRkB e mTOR. Concluímos que os inibidores da metilação do DNA apresentam agudamente… Advisors/Committee Members: Sâmia Regiane Lourenço Joca, Flavio da Silva Emery, Stela Maris Kuze Rates.

Subjects/Keywords: antidepressivo; BDNF; inibidores de metilação do DNA; mTOR; nado forçado.; TRkB; antidepressant; BDNF; forced swimming test.; inhibitors of methylation; mTOR; TRkB

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Suavinha, A. C. D. R. (2014). Participação da via BDNF-TRkB-mTor do córtex pré-frontal medial ventral no efeito tipo antidepressivo induzido por inibidores da metilação do DNA. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/60/60138/tde-24062014-092102/

Chicago Manual of Style (16^th Edition):

Suavinha, Angélica Caroline Dutra Romano. “Participação da via BDNF-TRkB-mTor do córtex pré-frontal medial ventral no efeito tipo antidepressivo induzido por inibidores da metilação do DNA.” 2014. Masters Thesis, University of São Paulo. Accessed April 10, 2021. http://www.teses.usp.br/teses/disponiveis/60/60138/tde-24062014-092102/.

MLA Handbook (7^th Edition):

Suavinha, Angélica Caroline Dutra Romano. “Participação da via BDNF-TRkB-mTor do córtex pré-frontal medial ventral no efeito tipo antidepressivo induzido por inibidores da metilação do DNA.” 2014. Web. 10 Apr 2021.

Vancouver:

Suavinha ACDR. Participação da via BDNF-TRkB-mTor do córtex pré-frontal medial ventral no efeito tipo antidepressivo induzido por inibidores da metilação do DNA. [Internet] [Masters thesis]. University of São Paulo; 2014. [cited 2021 Apr 10]. Available from: http://www.teses.usp.br/teses/disponiveis/60/60138/tde-24062014-092102/.

Council of Science Editors:

Suavinha ACDR. Participação da via BDNF-TRkB-mTor do córtex pré-frontal medial ventral no efeito tipo antidepressivo induzido por inibidores da metilação do DNA. [Masters Thesis]. University of São Paulo; 2014. Available from: http://www.teses.usp.br/teses/disponiveis/60/60138/tde-24062014-092102/

27. Hufgard, Jillian R. PDE1B KO Confers Resilience to Acute Stress-induced Depression-like Behavior.

Degree: PhD, Medicine: Molecular and Developmental Biology, 2017, University of Cincinnati

URL: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1504803606103525

► Phosphodiesterases (PDE) regulate secondary messengers such as cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) by hydrolyzing the phosphodiester bond. There are over 100… (more)

▼ Phosphodiesterases (PDE) regulate secondary messengers such as cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) by hydrolyzing the phosphodiester bond. There are over 100 PDE proteins that are categorized into 11 families. Each protein family has a unique tissue distribution and binding affinity for cAMP and/or cGMP. The modulation of different PDEs has been used to treat several disorders: inflammation, erectile dysfunction, and neurological disorders. Recently, PDE inhibitors were implicated for therapeutic benefits in Alzheimer’s disease, depression, Huntington’s disease, Parkinson’s disease, schizophrenia, and substance abuse. PDE1B is found in the caudate-putamen, nucleus accumbens, dentate gyrus, and substantia nigra–areas linked to depression. PDE1B expression is also increased after acute and chronic stress. Two ubiquitous Pde1b knockout (KO) mouse models, both removing part of the catalytic region, decreased immobility on two acute stress tests associated with depression-like behavior; tail suspension test (TST) and forced swim test (FST). The decreases in immobility suggest resistance to depression-like behavior, and these effects were additive when combined with two current antidepressants, fluoxetine and bupropion. The resistance to induced immobility was seen when PDE1B was knocked down during adolescence or earlier. Expression of Pde1b mRNA and protein showed that Pde1b is localized to dopaminergic and glutamatergic post-synaptic cells. Serotonin transporter, dopamine transporter, and dopamine receptor D1a (Drd1a) Cre drivers were tested and only Pde1b KO in Drd1a specific cells was sufficient to reproduce the immobility phenotype in TST. Intrastriatal injections of dopamine receptor, D1, agonist (SKF38393) and antagonist (SCH23390) revealed an additive immobility effect of Pde1b KO and dopamine receptor antagonism. The D1 agonist reversed the genotype immobility phenotype. The results suggest that reduction of PDE1B causes resistance to acute stress-induced depression-like behaviors through the dopamine pathways. Advisors/Committee Members: Vorhees, Charles (Committee Chair).

Subjects/Keywords: Neurology; Phosphodiesterase; depression; tail suspension test; forced swim test; dopamine

…al., 2013). They also showed an increase in forced swim test (FST)… …1a cells confers an immobility-resistant phenotype in forced swim and tail suspension tests… …Dopamine receptor dopamine Epac Exchange factor directly activated by cAMP FST Forced swim… …test GABA gamma-Aminobutyric acid GLUT Glutamate transporter HD Huntington's… …Standard error of the mean SERT Serotonin transporter TST Tail suspension test WT Wild-type…

10 more images…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hufgard, J. R. (2017). PDE1B KO Confers Resilience to Acute Stress-induced Depression-like Behavior. (Doctoral Dissertation). University of Cincinnati. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=ucin1504803606103525

Chicago Manual of Style (16^th Edition):

Hufgard, Jillian R. “PDE1B KO Confers Resilience to Acute Stress-induced Depression-like Behavior.” 2017. Doctoral Dissertation, University of Cincinnati. Accessed April 10, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1504803606103525.

MLA Handbook (7^th Edition):

Hufgard, Jillian R. “PDE1B KO Confers Resilience to Acute Stress-induced Depression-like Behavior.” 2017. Web. 10 Apr 2021.

Vancouver:

Hufgard JR. PDE1B KO Confers Resilience to Acute Stress-induced Depression-like Behavior. [Internet] [Doctoral dissertation]. University of Cincinnati; 2017. [cited 2021 Apr 10]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1504803606103525.

Council of Science Editors:

Hufgard JR. PDE1B KO Confers Resilience to Acute Stress-induced Depression-like Behavior. [Doctoral Dissertation]. University of Cincinnati; 2017. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1504803606103525

Leiden University

28. Vinck, Willemijn. Advertising and memory: The modulation of eye vergence applied in marketing.

Degree: 2017, Leiden University

URL: http://hdl.handle.net/1887/46690

Subjects/Keywords: eyetracking; vergence; advertisement

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Vinck, W. (2017). Advertising and memory: The modulation of eye vergence applied in marketing. (Masters Thesis). Leiden University. Retrieved from http://hdl.handle.net/1887/46690

Chicago Manual of Style (16^th Edition):

Vinck, Willemijn. “Advertising and memory: The modulation of eye vergence applied in marketing.” 2017. Masters Thesis, Leiden University. Accessed April 10, 2021. http://hdl.handle.net/1887/46690.

MLA Handbook (7^th Edition):

Vinck, Willemijn. “Advertising and memory: The modulation of eye vergence applied in marketing.” 2017. Web. 10 Apr 2021.

Vancouver:

Vinck W. Advertising and memory: The modulation of eye vergence applied in marketing. [Internet] [Masters thesis]. Leiden University; 2017. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/1887/46690.

Council of Science Editors:

Vinck W. Advertising and memory: The modulation of eye vergence applied in marketing. [Masters Thesis]. Leiden University; 2017. Available from: http://hdl.handle.net/1887/46690

University of Waterloo

29. Erkelens, Ian. The adaptive elements of disparity vergence: Dynamics and directional asymmetries.

Degree: 2018, University of Waterloo

URL: http://hdl.handle.net/10012/13173

► Vergence eye movements alter the angle between the two visual axes, creating changes in binocular fixation distance. They are primarily stimulated by retinal image disparities,… (more)

▼ Vergence eye movements alter the angle between the two visual axes, creating changes in binocular fixation distance. They are primarily stimulated by retinal image disparities, but can also be driven by inputs from ocular accommodation (accommodative-vergence) and perceived proximity (size) changes. Because of these diverse and complex sensory inputs, the neuro-motor substrates that sub-serve vergence control possess robust adaptive capabilities to manage the interactions with other oculomotor systems (accommodation). This adaptive plasticity in vergence allows for a high degree of precision in binocular alignment to be maintained throughout life in the face of constantly changing environmental demands. The precise alignment of each eyes’ fovea is a fundamental requirement for stereopsis and the perception of depth in 3 dimensions. In a significant portion of the ophthalmic clinical population, the adaptive capacities of vergence are reduced or dysfunctional, leading to difficulties focusing clearly and comfortably at near distances such as books, computer screens and other hand-held devices. Furthermore, new wearable technologies such as virtual and augmented reality increase the demand on the adaptive capacities of vergence by drastically altering the congruency of the sensory inputs to vergence. Currently, our understanding of the mechanisms that underlie this adaptive control and their behavioral limits are limited. This knowledge gap has led to conjecture in the literature regarding proper rehabilitative therapies for clinical dysfunctions of vergence control and in the optimal environmental design parameters that should provide comfortable and compelling user experiences in wearable technologies like VR and AR. The inward (convergence) and the outward (divergence) turning of the eyes in response to retinal disparities are controlled by two separate systems and demonstrate significant directional asymmetries in their reflexive response properties. In general, reflexive divergence responses tend to be slower and longer than their convergence counter-parts. It is unclear whether the adaptive mechanisms are influence by these reflexive asymmetries. It is also unknown whether similar directional differences exist in the different adaptive capacities possessed by vergence. The purpose of the following dissertation was to characterize the effects of stimulus direction on the adaptive behavior of disparity-driven vergence eye movements with an end goal aimed at improving rehabilitation therapies for clinical populations with vergence dysfunction and providing valuable insight for the design and future development of wearable technologies like virtual and augmented reality environments. A series of 4 experiments were conducted in order to characterize the effect of stimulus direction and the physiological limits of the adaptive behavior within the two-main disparity vergence motor controllers, fast-phasic and slow-tonic. In each study, binocular viewing conditions were dichoptic, which allowed retinal disparity to…

Subjects/Keywords: eye movement control; adaptation; vergence; plasticity

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Erkelens, I. (2018). The adaptive elements of disparity vergence: Dynamics and directional asymmetries. (Thesis). University of Waterloo. Retrieved from http://hdl.handle.net/10012/13173

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Erkelens, Ian. “The adaptive elements of disparity vergence: Dynamics and directional asymmetries.” 2018. Thesis, University of Waterloo. Accessed April 10, 2021. http://hdl.handle.net/10012/13173.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Erkelens, Ian. “The adaptive elements of disparity vergence: Dynamics and directional asymmetries.” 2018. Web. 10 Apr 2021.

Vancouver:

Erkelens I. The adaptive elements of disparity vergence: Dynamics and directional asymmetries. [Internet] [Thesis]. University of Waterloo; 2018. [cited 2021 Apr 10]. Available from: http://hdl.handle.net/10012/13173.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Erkelens I. The adaptive elements of disparity vergence: Dynamics and directional asymmetries. [Thesis]. University of Waterloo; 2018. Available from: http://hdl.handle.net/10012/13173

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Hong Kong University of Science and Technology

30. Zhao, Zhetuo. Learning hierarchical integration of foveal and peripheral vision for vergence control.

Degree: 2016, Hong Kong University of Science and Technology

URL: http://repository.ust.hk/ir/Record/1783.1-86951 ; https://doi.org/10.14711/thesis-b1626123 ; http://repository.ust.hk/ir/bitstream/1783.1-86951/1/th_redirect.html

► Joint development of perception and behavior based on efficient coding theory has been proposed and proved to be an effective approach in the study of… (more)

Subjects/Keywords: Eye tracking ; Vergence (Binocular vision) ; Peripheral vision

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APA (6^th Edition):

Zhao, Z. (2016). Learning hierarchical integration of foveal and peripheral vision for vergence control. (Thesis). Hong Kong University of Science and Technology. Retrieved from http://repository.ust.hk/ir/Record/1783.1-86951 ; https://doi.org/10.14711/thesis-b1626123 ; http://repository.ust.hk/ir/bitstream/1783.1-86951/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Zhao, Zhetuo. “Learning hierarchical integration of foveal and peripheral vision for vergence control.” 2016. Thesis, Hong Kong University of Science and Technology. Accessed April 10, 2021. http://repository.ust.hk/ir/Record/1783.1-86951 ; https://doi.org/10.14711/thesis-b1626123 ; http://repository.ust.hk/ir/bitstream/1783.1-86951/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Zhao, Zhetuo. “Learning hierarchical integration of foveal and peripheral vision for vergence control.” 2016. Web. 10 Apr 2021.

Vancouver:

Zhao Z. Learning hierarchical integration of foveal and peripheral vision for vergence control. [Internet] [Thesis]. Hong Kong University of Science and Technology; 2016. [cited 2021 Apr 10]. Available from: http://repository.ust.hk/ir/Record/1783.1-86951 ; https://doi.org/10.14711/thesis-b1626123 ; http://repository.ust.hk/ir/bitstream/1783.1-86951/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Zhao Z. Learning hierarchical integration of foveal and peripheral vision for vergence control. [Thesis]. Hong Kong University of Science and Technology; 2016. Available from: http://repository.ust.hk/ir/Record/1783.1-86951 ; https://doi.org/10.14711/thesis-b1626123 ; http://repository.ust.hk/ir/bitstream/1783.1-86951/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Open Access Theses and Dissertations