Open Access Theses and Dissertations

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You searched for subject:(fetal disposition). Showing records 1 – 2 of 2 total matches.

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University of Georgia

1. Lewis, Summer Renee. Maternal and fetal disposition of antiviral agents in the pregnant rat.

Degree: 2014, University of Georgia

URL: http://hdl.handle.net/10724/23173 

Human immunodeficiency virus type-1 (HIV) infection has increased dramatically in pregnant women, thus, exposing the fetus in utero. However, with the increasing use of combination therapies, drug-drug interactions causing significant health risks are becoming more common. Therefore, antiviral drugs are used therapeutically in pregnancy for the treatment of the mother and the fetus. Antiviral drugs are presumed to prevent the transmission of infections from mother to fetus by decreasing maternal viral load and/or accumulation of drugs in the fetal compartment. Drugs enter the fetal compartment through either passive diffusion and/or active transport across the placenta. Studies with single antiviral agents suggest that these drugs cross the placenta by passive diffusion. However, recent studies have identified several nucleoside transporters in the placenta. To date, very few studies have examined the fetal disposition of drugs administered in combination. To understand these interactions, the pharmacokinetics of these antiretroviral agents, alone and in combination, must be fully understood in both mother and fetus in order to successfully treat pregnant HIV positive women.

Subjects/Keywords: Pharmacokinetics; HIV; Abacavir; Lamivudine; 3TC; Zidovudine; AZT; placental transport; antiviral; fetal disposition

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Lewis, S. R. (2014). Maternal and fetal disposition of antiviral agents in the pregnant rat. (Thesis). University of Georgia. Retrieved from http://hdl.handle.net/10724/23173

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Lewis, Summer Renee. “Maternal and fetal disposition of antiviral agents in the pregnant rat.” 2014. Thesis, University of Georgia. Accessed April 15, 2021. http://hdl.handle.net/10724/23173.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Lewis, Summer Renee. “Maternal and fetal disposition of antiviral agents in the pregnant rat.” 2014. Web. 15 Apr 2021.

Vancouver:

Lewis SR. Maternal and fetal disposition of antiviral agents in the pregnant rat. [Internet] [Thesis]. University of Georgia; 2014. [cited 2021 Apr 15]. Available from: http://hdl.handle.net/10724/23173.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lewis SR. Maternal and fetal disposition of antiviral agents in the pregnant rat. [Thesis]. University of Georgia; 2014. Available from: http://hdl.handle.net/10724/23173

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


University of Georgia

2. Xu, Meng. Quantitative analysis and pharmacokinetics of antiviral agents in the pregnant rat.

Degree: 2014, University of Georgia

URL: http://hdl.handle.net/10724/25093 

Antiviral drugs are used therapeutically in pregnancy for treatment of both mother and fetus. Antiviral drugs are presumed to prevent viral transmission from mother to fetus by decreasing maternal viral load and/or accumulation of the drugs in the fetal compartment. Due to a number of reasons, pregnant women are generally not used during clinical trials, so very little is known about the behavior of therapeutic agents during pregnancy. A pregnant rat model has been developed to investigate the pharmacokinetics and placental transport of antivirals during pregnancy. Presented here are validated analytical methods for the extraction and quantitation of the nucleoside reverse transcriptase inhibitors zalcitabine (DDC) and stavudine (D4T) in the various matrices needed to support the maternal-fetal pharmacokinetic studies. Also presented here are the pharmacokinetics of DDC and D4T, using the pregnant rat model.

Subjects/Keywords: Analytical; Pharmacokinetics; HIV; Zalcitabine; DDC; Stavudine; D4T; Lamivudine; 3TC; placental transport; fetal disposition

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Xu, M. (2014). Quantitative analysis and pharmacokinetics of antiviral agents in the pregnant rat. (Thesis). University of Georgia. Retrieved from http://hdl.handle.net/10724/25093

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Xu, Meng. “Quantitative analysis and pharmacokinetics of antiviral agents in the pregnant rat.” 2014. Thesis, University of Georgia. Accessed April 15, 2021. http://hdl.handle.net/10724/25093.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Xu, Meng. “Quantitative analysis and pharmacokinetics of antiviral agents in the pregnant rat.” 2014. Web. 15 Apr 2021.

Vancouver:

Xu M. Quantitative analysis and pharmacokinetics of antiviral agents in the pregnant rat. [Internet] [Thesis]. University of Georgia; 2014. [cited 2021 Apr 15]. Available from: http://hdl.handle.net/10724/25093.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Xu M. Quantitative analysis and pharmacokinetics of antiviral agents in the pregnant rat. [Thesis]. University of Georgia; 2014. Available from: http://hdl.handle.net/10724/25093

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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