subject:(female reproductive tract)

University of Houston

1. Mehta, Fabiola Melissa 1985-. Suppression of Cervical Cancer by the Progesterone Receptor Signaling.

Degree: PhD, Biology, 2016, University of Houston

► Cervical cancer is the fourth-most common cancer in woman and fourth leading cause of cancer death worldwide. The majority of cervical cancer is associated with… (more)

▼ Cervical cancer is the fourth-most common cancer in woman and fourth leading cause of cancer death worldwide. The majority of cervical cancer is associated with high-risk human papillomaviruses (HPVs). Their tumorigenic potential stems mainly from viral oncoproteins E6 and E7, which are best known to inactivate p53 and pRb tumor suppressor, respectively. Epidemiological evidence suggests that, in addition to persistent HPV infections, other cofactors are required for cervical cancer. Multiple pregnancies and oral contraceptive use increases the risk for cervical cancer in HPV-infected women, implicating a role of estrogen and progesterone in cervical cancer. Prior studies utilizing an HPV transgenic mouse model expressing E6 and E7 (K14E6/K14E7) have demonstrated the requirement of estrogen receptor alpha (ERα) and estradiol (E2) for cervical carcinogenesis. Accumulating evidence suggests that ERα may be important for human cervical cancer. The role of progesterone and progesterone receptor (PR) in cervical cancer remains elusive. Our laboratory has demonstrated that PR agonist medroxyprogesterone acetate (MPA) promotes regression of cervical cancer and cervical intraepithelial neoplasia (CIN) in the K14E6/K14E7 mice. Goals of my dissertation project were to determine whether cervical cancer recurs after MPA therapy and whether epithelial PR is required for therapeutic effect of MPA. Using the K14E6/K14E7 mice, I found that cervical cancer recurred even if MPA treatment was continued, and recurring cervical cancer expressed PR but was refractory to MPA. In addition to PR, MPA interacts with other nuclear receptors including glucocorticoid receptor. Using the Cre/LoxP recombination system, I found that epithelial PR promoted apoptosis and inhibited proliferation in the cervical epithelium. I also determined that epithelial PR was required for MPA-mediated regression of cervical cancer, which was inhibited by E2. My results strongly support the hypothesis that epithelial PR is ligand-dependent tumor suppressor in cervical cancer. Approximately 33% of cervical cancer expresses PR. My results suggest that PR expression may not be sufficient to benefit from MPA therapy. My results also warrants further study to determine mechanism of recurrence and therapy resistance, which will facilitate the development of a better therapy for the disease. Advisors/Committee Members: Chung, Sang-Hyuk (advisor), Bawa-Khalfe, Tasneem (committee member), Frigo, Daniel E. (committee member), Weigel, Nancy L. (committee member).

Subjects/Keywords: Progesterone receptor; Cervical cancer; Female reproductive tract

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APA (6^th Edition):

Mehta, F. M. 1. (2016). Suppression of Cervical Cancer by the Progesterone Receptor Signaling. (Doctoral Dissertation). University of Houston. Retrieved from http://hdl.handle.net/10657/3271

Chicago Manual of Style (16^th Edition):

Mehta, Fabiola Melissa 1985-. “Suppression of Cervical Cancer by the Progesterone Receptor Signaling.” 2016. Doctoral Dissertation, University of Houston. Accessed April 17, 2021. http://hdl.handle.net/10657/3271.

MLA Handbook (7^th Edition):

Mehta, Fabiola Melissa 1985-. “Suppression of Cervical Cancer by the Progesterone Receptor Signaling.” 2016. Web. 17 Apr 2021.

Vancouver:

Mehta FM1. Suppression of Cervical Cancer by the Progesterone Receptor Signaling. [Internet] [Doctoral dissertation]. University of Houston; 2016. [cited 2021 Apr 17]. Available from: http://hdl.handle.net/10657/3271.

Council of Science Editors:

Mehta FM1. Suppression of Cervical Cancer by the Progesterone Receptor Signaling. [Doctoral Dissertation]. University of Houston; 2016. Available from: http://hdl.handle.net/10657/3271

Georgia Tech

2. Lindsay, Kevin E. Orthogonal platforms to modulate, monitor, and deliver mRNA in vivo.

Degree: PhD, Biomedical Engineering (Joint GT/Emory Department), 2018, Georgia Tech

URL: http://hdl.handle.net/1853/61677

► Delivering molecular immunotherapies to the necessary organs is a frequent bottleneck in translating drugs to the clinic. We directly associate adjuvants to naked mRNA in… (more)

Subjects/Keywords: Synthetic mRNA; PET imaging; HIV; Female reproductive tract

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APA (6^th Edition):

Lindsay, K. E. (2018). Orthogonal platforms to modulate, monitor, and deliver mRNA in vivo. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/61677

Chicago Manual of Style (16^th Edition):

Lindsay, Kevin E. “Orthogonal platforms to modulate, monitor, and deliver mRNA in vivo.” 2018. Doctoral Dissertation, Georgia Tech. Accessed April 17, 2021. http://hdl.handle.net/1853/61677.

MLA Handbook (7^th Edition):

Lindsay, Kevin E. “Orthogonal platforms to modulate, monitor, and deliver mRNA in vivo.” 2018. Web. 17 Apr 2021.

Vancouver:

Lindsay KE. Orthogonal platforms to modulate, monitor, and deliver mRNA in vivo. [Internet] [Doctoral dissertation]. Georgia Tech; 2018. [cited 2021 Apr 17]. Available from: http://hdl.handle.net/1853/61677.

Council of Science Editors:

Lindsay KE. Orthogonal platforms to modulate, monitor, and deliver mRNA in vivo. [Doctoral Dissertation]. Georgia Tech; 2018. Available from: http://hdl.handle.net/1853/61677

University of Washington

3. DavÃ©, Veronica Anjali. T cell immunity in the female genital tract.

Degree: PhD, 2021, University of Washington

URL: http://hdl.handle.net/1773/46869

► Many pathogens of global health significance are sexually transmitted, highlighting the importance of studying immune cells in genital barrier tissues. T cells are a critical… (more)

▼ Many pathogens of global health significance are sexually transmitted, highlighting the importance of studying immune cells in genital barrier tissues. T cells are a critical component of the immune response to viruses, yet their role in protecting the female genital tract against viral infection is incompletely understood. Here, we combined studies of the mouse and human female genital tract to characterize T cells isolated from female genital barrier tissues. In human cervicovaginal tissue, CD8 T cells resembled effector T cells, raising the question of whether they were recently activated. By employing mouse models, we found that systemic immunization resulted in a cervicovaginal CD8 T cell compartment that was poorly maintained and underwent progressive differentiation that was not observed in spleen, lymph nodes, or small intestine lamina propria. This progressive differentiation occurred over five months, after which CD8 T cells gained an effector-like phenotype, ultimately resembling human cervicovaginal CD8 T cells. Vaginal inflammation combined with vaginal antigen exposure accelerated this differentiation process. The CD8 T cell compartment induced by systemic immunization mediated partial protection against vaginal infection with herpes simplex virus type 2 (HSV-2). This protection waned over time as the loss and differentiation of the CD8 T cell compartment progressed. Together, these results demonstrate that tissue-intrinsic factors interact with environmental cues to dictate the final longevity and phenotype of the cervicovaginal CD8 T cell compartment.Women living with HSV-2 often experience recurring genital herpes lesions. We explored the T cell compartment in human genital skin during these localized HSV-2 reactivation events. Upon HSV-2 lesion formation, we found that CD4 and CD8 T cells expanded in the infected skin site and upregulated markers of proliferation and activation. Some of the expanded T cells resembled circulating memory T cells, suggesting influx of immune cells from the blood. Cell-intrinsic and cell-extrinsic regulatory mechanisms were also upregulated in HSV-2 lesions, indicating that the immune system acted to control the virus as well as limit immunopathology. Meanwhile, T cells isolated from a nearby unaffected region distinct from the HSV-2 lesion were quiescent, instead resembling the T cell isolate from genital biopsies from HSV seronegative participants. Despite the frequency of HSV-2 reactivation in people with chronic genital herpes, we did not observe evidence of T cell exhaustion or loss of functionality. After lesion resolution, the T cell infiltrate in HSV-2 lesions returned to quiescence, again resembling the T cell compartment in contralateral and seronegative control biopsies. Given these results, we conclude that T cell responses to HSV-2 reactivation events in genital skin are highly localized, include both resident T cells and circulating memory T cells, and are rapidly constrained by regulatory T cells and intrinsic regulatory mechanisms. Taken together, our… Advisors/Committee Members: Lund, Jennifer (advisor), Prlic, Martin (advisor).

Subjects/Keywords: female genital tract; female reproductive tract; herpes simplex virus; mucosal immunology; sexually transmitted infections; T cell; Immunology; Virology; Biology; Pathobiology

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APA (6^th Edition):

DavÃ©, V. A. (2021). T cell immunity in the female genital tract. (Doctoral Dissertation). University of Washington. Retrieved from http://hdl.handle.net/1773/46869

Chicago Manual of Style (16^th Edition):

DavÃ©, Veronica Anjali. “T cell immunity in the female genital tract.” 2021. Doctoral Dissertation, University of Washington. Accessed April 17, 2021. http://hdl.handle.net/1773/46869.

MLA Handbook (7^th Edition):

DavÃ©, Veronica Anjali. “T cell immunity in the female genital tract.” 2021. Web. 17 Apr 2021.

Vancouver:

DavÃ© VA. T cell immunity in the female genital tract. [Internet] [Doctoral dissertation]. University of Washington; 2021. [cited 2021 Apr 17]. Available from: http://hdl.handle.net/1773/46869.

Council of Science Editors:

DavÃ© VA. T cell immunity in the female genital tract. [Doctoral Dissertation]. University of Washington; 2021. Available from: http://hdl.handle.net/1773/46869

Universiteit Utrecht

4. Buck, Carolien. Detection of Leptospira organism in the female reproductive tract of farmed deer in New Zealand.

Degree: 2008, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/32490

► Leptospirosis is a big zoonotic problem in deer in New Zealand. To find out if leptospira can also cause reproductive failure, there was a research… (more)

Subjects/Keywords: Diergeneeskunde; Leptospires; Leptospira; Hardjobovis; Pomona; farmed deer; female reproductive tract; uterus; New Zealand

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APA (6^th Edition):

Buck, C. (2008). Detection of Leptospira organism in the female reproductive tract of farmed deer in New Zealand. (Doctoral Dissertation). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/32490

Chicago Manual of Style (16^th Edition):

Buck, Carolien. “Detection of Leptospira organism in the female reproductive tract of farmed deer in New Zealand.” 2008. Doctoral Dissertation, Universiteit Utrecht. Accessed April 17, 2021. http://dspace.library.uu.nl:8080/handle/1874/32490.

MLA Handbook (7^th Edition):

Buck, Carolien. “Detection of Leptospira organism in the female reproductive tract of farmed deer in New Zealand.” 2008. Web. 17 Apr 2021.

Vancouver:

Buck C. Detection of Leptospira organism in the female reproductive tract of farmed deer in New Zealand. [Internet] [Doctoral dissertation]. Universiteit Utrecht; 2008. [cited 2021 Apr 17]. Available from: http://dspace.library.uu.nl:8080/handle/1874/32490.

Council of Science Editors:

Buck C. Detection of Leptospira organism in the female reproductive tract of farmed deer in New Zealand. [Doctoral Dissertation]. Universiteit Utrecht; 2008. Available from: http://dspace.library.uu.nl:8080/handle/1874/32490

University of Manitoba

5. Yazdanpanah, Atta. Understanding the role of neutrophils in female reproductive tract (FRT) epithelial barrier remodeling in vivo.

Degree: Immunology, 2019, University of Manitoba

URL: http://hdl.handle.net/1993/33915

► When the mucous membrane of the female reproductive tract (FRT) is compromised, women are more susceptible to pathogens, especially human immunodeficiency virus (HIV), which emphasizes… (more)

▼ When the mucous membrane of the female reproductive tract (FRT) is compromised, women are more susceptible to pathogens, especially human immunodeficiency virus (HIV), which emphasizes the importance of an intact barrier in female vaginal health. In a large human cohort analysis, previous studies have observed a strong association between neutrophil activation, epithelial barrier damage and HIV infection, supporting the hypothesis that these innate cells are an important modulator of the vaginal mucosal barrier and HIV susceptibility. However, a gap in knowledge is the biological mechanisms that regulate the recruitment of neutrophils and their interaction with the vaginal epithelium. Here, we show, using a mouse model, that neutrophils are recruited into the vaginal mucosa in response to progesterone. Proteomic analysis of the cervicovaginal lavage fluid revealed that pathways involved in epithelial barrier disruption were activated, and that these pathways were significantly reduced after in vivo depletion of neutrophils. We show that vaginal neutrophils expressed high levels of CXCR2 that allowed their positioning along the outer layers of the vaginal epithelium. Vaginal inoculation of BSA at steady-state and neutrophil depletion did not assign neutrophils to epithelial disruption. Furthermore, elevated expression of neutrophil-associated mediators MPO, MMP8 and elastase in the diestrus phase were observed. In the presence of anaerobic bacteria that are associated with bacterial vaginosis (BV), expression of neutrophil elastase, MMP8, and MMP9 trended higher, suggesting that different bacteria species can elevate inflammation reactions by activating mucosal neutrophils. These data argue that the mouse model can recapitulate key aspects of neutrophil:epithelium interactions in vivo. Our overall goal is to further define the role of mucosal neutrophils, and whether blocking their recruitment/activation can reduce HIV susceptibility. Advisors/Committee Members: Murooka, Thomas (Immunology) (supervisor), Kung, Sam (Immunology) Keynan, Yoav (Medical Microbiology and Infectious Diseases) (examiningcommittee).

Subjects/Keywords: Female reproductive tract (FRT); Neutrophils; Cervicovaginal lavage; Bacterial vaginosis (BV); HIV susceptibility

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APA (6^th Edition):

Yazdanpanah, A. (2019). Understanding the role of neutrophils in female reproductive tract (FRT) epithelial barrier remodeling in vivo. (Masters Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/33915

Chicago Manual of Style (16^th Edition):

Yazdanpanah, Atta. “Understanding the role of neutrophils in female reproductive tract (FRT) epithelial barrier remodeling in vivo.” 2019. Masters Thesis, University of Manitoba. Accessed April 17, 2021. http://hdl.handle.net/1993/33915.

MLA Handbook (7^th Edition):

Yazdanpanah, Atta. “Understanding the role of neutrophils in female reproductive tract (FRT) epithelial barrier remodeling in vivo.” 2019. Web. 17 Apr 2021.

Vancouver:

Yazdanpanah A. Understanding the role of neutrophils in female reproductive tract (FRT) epithelial barrier remodeling in vivo. [Internet] [Masters thesis]. University of Manitoba; 2019. [cited 2021 Apr 17]. Available from: http://hdl.handle.net/1993/33915.

Council of Science Editors:

Yazdanpanah A. Understanding the role of neutrophils in female reproductive tract (FRT) epithelial barrier remodeling in vivo. [Masters Thesis]. University of Manitoba; 2019. Available from: http://hdl.handle.net/1993/33915

University of KwaZulu-Natal

6. Takalani, Funanani. The biological mechanisms associated with Depo-Provera and HIV-1 risk acquisition in women.

Degree: 2017, University of KwaZulu-Natal

URL: https://researchspace.ukzn.ac.za/handle/10413/18501

► Thirty-six years after the first identification of AIDS, the spread of its aetiological agents continues unabated, human immunodeficiency virus 1 (HIV-1) in particular. About 40%… (more)

Subjects/Keywords: Female reproductive tract.; Depo-Provera.; Women with HIV.; HIV infections.; AIDS disease.

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APA (6^th Edition):

Takalani, F. (2017). The biological mechanisms associated with Depo-Provera and HIV-1 risk acquisition in women. (Thesis). University of KwaZulu-Natal. Retrieved from https://researchspace.ukzn.ac.za/handle/10413/18501

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Takalani, Funanani. “The biological mechanisms associated with Depo-Provera and HIV-1 risk acquisition in women.” 2017. Thesis, University of KwaZulu-Natal. Accessed April 17, 2021. https://researchspace.ukzn.ac.za/handle/10413/18501.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Takalani, Funanani. “The biological mechanisms associated with Depo-Provera and HIV-1 risk acquisition in women.” 2017. Web. 17 Apr 2021.

Vancouver:

Takalani F. The biological mechanisms associated with Depo-Provera and HIV-1 risk acquisition in women. [Internet] [Thesis]. University of KwaZulu-Natal; 2017. [cited 2021 Apr 17]. Available from: https://researchspace.ukzn.ac.za/handle/10413/18501.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Takalani F. The biological mechanisms associated with Depo-Provera and HIV-1 risk acquisition in women. [Thesis]. University of KwaZulu-Natal; 2017. Available from: https://researchspace.ukzn.ac.za/handle/10413/18501

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas Medical Center

7. Gonzalez, Gabriel. ROLE OF SOX9 IN UTERINE GLAND DEVELOPMENT AND DISEASE INITIATION.

Degree: PhD, 2012, Texas Medical Center

URL: https://digitalcommons.library.tmc.edu/utgsbs_dissertations/254

► The female reproductive tract (FRT) develops midway through embryogenesis, and consists of oviducts, uterine horns, cervix and upper part of the vagina. The uterine… (more)

▼ The female reproductive tract (FRT) develops midway through embryogenesis, and consists of oviducts, uterine horns, cervix and upper part of the vagina. The uterine horns are composed of an epithelial layer, luminal (LE) and glandular epithelium (GE), surrounded by a mesenchymal layer, the stroma and myometrium. Interestingly, in most mammals the GE forms after birth and it only becomes fully differentiated as the female reaches sexual maturity. Uterine glands (UG) are made up of GE and are present in all mammals. They secrete nutrients, cytokines and several other proteins, termed histotroph, that are necessary for embryo implantation and development. Experiments in ewes and mice have revealed that females who lack UGs are infertile mainly due to impaired implantation and early pregnancy loss, suggesting that UGs are essential for fertility. Fortunately for us, UGs develop after birth allowing us to peer into the genetic mechanism of tubulogenesis and branching morphogenesis; two processes that are disrupted in various adenocarcinomas (cancer derived from glands). We created 3D replicas of the epithelium lining the FRT using optical projection tomography and characterized UG development in mice using lineagetracing experiments. Our findings indicate that mouse UGs develop as simple tubular structures and later grow multiple secretory units that stem from the main duct. The main aim of this project was to study the role of SOX9 in the UGs. Preliminary studies revealed that Sox9 is mostly found in the nucleus of the GE. vii This observation led to the hypothesis that Sox9 plays a role in the formation and/or differentiation of the GE. To study the role of Sox9 in UGs differentiation, we conditionally knocked out and overexpressed Sox9 in both the LE and GE using the progesterone receptor (Pgr) promoter. Overexpressing Sox9 in the uterine epithelium, parts of the stroma, and myometrium led to formation of multiple cystic structures inside the endometrium. Histological analysis revealed that these structures appeared morphologically similar to structures present in histological tissue sections obtained from patients with endometrial polyps. We have accounted for the presence of simple and complex hyperplasia with atypia, metaplasia, thick-walled blood vessels, and stromal fibrosis; all “hallmarks” that indicate overexpressing Sox9 leads to development of a polyp-like morphology. Therefore, we can propose the use of Sox9-cOE mice to study development of endometrial cystic lesions and disease progression into hyperplastic lesions. Advisors/Committee Members: Richard R. Behringer, Ph.D., Michelle Barton, Ph.D., Russell Broaddus, M.D., Ph.D..

Subjects/Keywords: SOX9; Uterine Gland Hyperplasia; Female Reproductive Tract Development; Medicine and Health Sciences

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APA (6^th Edition):

Gonzalez, G. (2012). ROLE OF SOX9 IN UTERINE GLAND DEVELOPMENT AND DISEASE INITIATION. (Doctoral Dissertation). Texas Medical Center. Retrieved from https://digitalcommons.library.tmc.edu/utgsbs_dissertations/254

Chicago Manual of Style (16^th Edition):

Gonzalez, Gabriel. “ROLE OF SOX9 IN UTERINE GLAND DEVELOPMENT AND DISEASE INITIATION.” 2012. Doctoral Dissertation, Texas Medical Center. Accessed April 17, 2021. https://digitalcommons.library.tmc.edu/utgsbs_dissertations/254.

MLA Handbook (7^th Edition):

Gonzalez, Gabriel. “ROLE OF SOX9 IN UTERINE GLAND DEVELOPMENT AND DISEASE INITIATION.” 2012. Web. 17 Apr 2021.

Vancouver:

Gonzalez G. ROLE OF SOX9 IN UTERINE GLAND DEVELOPMENT AND DISEASE INITIATION. [Internet] [Doctoral dissertation]. Texas Medical Center; 2012. [cited 2021 Apr 17]. Available from: https://digitalcommons.library.tmc.edu/utgsbs_dissertations/254.

Council of Science Editors:

Gonzalez G. ROLE OF SOX9 IN UTERINE GLAND DEVELOPMENT AND DISEASE INITIATION. [Doctoral Dissertation]. Texas Medical Center; 2012. Available from: https://digitalcommons.library.tmc.edu/utgsbs_dissertations/254

Boston University

8. Baldeon Vaca, Gabriela Betsave. Topical use of monoclonal antibodies as a multipurpose prevention technology offering contraception and decreased transmission of HIV-1 and trichomonas vaginalis.

Degree: PhD, Molecular and Translational Medicine, 2020, Boston University

URL: http://hdl.handle.net/2144/39394

► New transgenic antibody production platforms enable cost-effective, rapid manufacturing of antibodies for clinical applications. Our lab is investigating a human monoclonal antibody, the Human Contraceptive… (more)

▼ New transgenic antibody production platforms enable cost-effective, rapid manufacturing of antibodies for clinical applications. Our lab is investigating a human monoclonal antibody, the Human Contraceptive Antibody (HCA), produced in Nicotiana benthamiana, as a candidate for a topical Multipurpose Prevention Technology offering both contraception and protection against sexually transmitted infections. HCA was developed from a sperm-agglutinating antibody isolated from plasma cells of an infertile woman. The antibody targets a GPI-anchored glycoprotein, CD52g, produced specifically by epithelial cells in the male reproductive tract (MRT). Due to its GPI anchor, the hypermobile protein coats sperm as they migrate through the MRT. In this study, we tested HCA’s specificity and contraceptive properties under physiologically relevant conditions in vitro. We demonstrated that HCA quickly and potently agglutinates sperm in physiological conditions at concentrations >6.25 μg/mL. Sperm concentration, soluble CD52g found in seminal plasma/whole semen, or prolonged exposure to the low pH found in the vaginal tract did not affect agglutination time. We also determined that CD52g incorporates into other cells present in the MRT, including human immunodeficiency virus (HIV-1) infected cells (lymphocytes, macrophages) and the parasite, Trichomonas vaginalis (TV), and that HIV virions produced from CD52g-coated cells incorporate CD52g in the virus particle membrane. HCA alone did not agglutinate HIV or TV. Both pathogens, however, appeared to co-agglutinate with sperm when co-cultures were treated with HCA. The trapping of pathogens in sperm agglutinates resulted in decreased TV adherence to MatTek tissue and vaginal epithelial cells, and a modest neutralization of HIV-1 in TZM-bl assays. These data indicate that HCA is a promising candidate to achieve contraception and decrease the male-to-female transmission of STI pathogens. Advisors/Committee Members: Anderson, Deborah (advisor), Sagar, Manish (advisor).

Subjects/Keywords: Biology; Antibodies; CD52g; Contraception; Female reproductive tract; Multipurpose prevention technology; Sexually transmitted infections

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APA (6^th Edition):

Baldeon Vaca, G. B. (2020). Topical use of monoclonal antibodies as a multipurpose prevention technology offering contraception and decreased transmission of HIV-1 and trichomonas vaginalis. (Doctoral Dissertation). Boston University. Retrieved from http://hdl.handle.net/2144/39394

Chicago Manual of Style (16^th Edition):

Baldeon Vaca, Gabriela Betsave. “Topical use of monoclonal antibodies as a multipurpose prevention technology offering contraception and decreased transmission of HIV-1 and trichomonas vaginalis.” 2020. Doctoral Dissertation, Boston University. Accessed April 17, 2021. http://hdl.handle.net/2144/39394.

MLA Handbook (7^th Edition):

Baldeon Vaca, Gabriela Betsave. “Topical use of monoclonal antibodies as a multipurpose prevention technology offering contraception and decreased transmission of HIV-1 and trichomonas vaginalis.” 2020. Web. 17 Apr 2021.

Vancouver:

Baldeon Vaca GB. Topical use of monoclonal antibodies as a multipurpose prevention technology offering contraception and decreased transmission of HIV-1 and trichomonas vaginalis. [Internet] [Doctoral dissertation]. Boston University; 2020. [cited 2021 Apr 17]. Available from: http://hdl.handle.net/2144/39394.

Council of Science Editors:

Baldeon Vaca GB. Topical use of monoclonal antibodies as a multipurpose prevention technology offering contraception and decreased transmission of HIV-1 and trichomonas vaginalis. [Doctoral Dissertation]. Boston University; 2020. Available from: http://hdl.handle.net/2144/39394

Texas A&M University

9. Rathmann, Ryan James. Effects of conventional or low bull to female ratio and utilization of reproductive tract scores in extensively-managed, natural mating breeding groups.

Degree: MS, Physiology of Reproduction, 2007, Texas A&M University

URL: http://hdl.handle.net/1969.1/4676

► The current study involved two experiments which were conducted at the Texas A&M Agricultural Research and Extension Center in Uvalde (semi-arid environment) from 2002 to… (more)

▼ The current study involved two experiments which were conducted at the Texas A&M Agricultural Research and Extension Center in Uvalde (semi-arid environment) from 2002 to 2004. In experiment one, Bonsmara bulls (n = 19; 20-24 mo of age) were joined with multiparous, crossbred females (n =586) for 90 d in 2003 and 2004. Bulls were allotted by selected physical traits, seminal traits, social rank, and serving capacity to one of two bull to female ratio (BFR) treatments: Conventional (1:21-1:29; n = 6 pastures) or Low (1:47-1:52; n = 2 pastures) BFR. Pregnancy rate (P = 0.33), calving rate (P = 0.26), and calving date (P = 0.22) did not differ between Conventional and Low BFR treatments. Post-breeding evaluation of bulls in 2002 (n = 16) indicated that social rank, but not seminal traits, was significantly correlated with pre-breeding values (P < 0.05). The current study demonstrates that Low BFR can be utilized in single- and multisire, 90-d breeding pastures of up to 2,090 ha without adversely affecting reproductive performance. In experiment two, yearling, one-half or three-quarter Bonsmara heifers (n = 106; 11-14 mo of age) were palpated per rectum and assigned a reproductive tract score (RTS) immediately prior to the beginning of the breeding season. Reproductive performance was measured in their two subsequent breeding years in order to estimate the value of the RTS system in extensively-managed, natural mating, 90-d breeding season programs. RTS was positively correlated (p < 0.01) with frame score (r = 0.25), age (r = 0.31), weaning weight (r = 0.47), and the weight of the heifer on the day of RTS exam (r = 0.56). The RTS means by dam parity also differed (P < 0.03). A lower (P < 0.01) percentage of females conceived during each of their first two breeding seasons for heifers of RTS 1 and 2 (65.2%) than for heifers of RTS 3, 4, and 5 (91.2%). Females with a RTS of 1 had a lower pregnancy rate over each of their first two breeding seasons, conceived later during their first breeding season, weaned lighter first calves, and remained lighter each year for fall body weight and body condition score than did heifers with RTS of 2 to 5 (P < 0.05). Collectively, the results of the current study indicate that heifers with a RTS of 1 immediately prior to a 90-d breeding season should be culled. Consideration should also be given to eliminating RTS 2 heifers, but further studies will be needed to confirm the potential economic advantage of this practice. Advisors/Committee Members: Forrest, David (advisor), Sprott, L.R. (advisor), Barling, Kerry (committee member), Holloway, Bill (committee member).

Subjects/Keywords: Bull to Female Ratio; Reproductive Tract Score

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APA (6^th Edition):

Rathmann, R. J. (2007). Effects of conventional or low bull to female ratio and utilization of reproductive tract scores in extensively-managed, natural mating breeding groups. (Masters Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/4676

Chicago Manual of Style (16^th Edition):

Rathmann, Ryan James. “Effects of conventional or low bull to female ratio and utilization of reproductive tract scores in extensively-managed, natural mating breeding groups.” 2007. Masters Thesis, Texas A&M University. Accessed April 17, 2021. http://hdl.handle.net/1969.1/4676.

MLA Handbook (7^th Edition):

Rathmann, Ryan James. “Effects of conventional or low bull to female ratio and utilization of reproductive tract scores in extensively-managed, natural mating breeding groups.” 2007. Web. 17 Apr 2021.

Vancouver:

Rathmann RJ. Effects of conventional or low bull to female ratio and utilization of reproductive tract scores in extensively-managed, natural mating breeding groups. [Internet] [Masters thesis]. Texas A&M University; 2007. [cited 2021 Apr 17]. Available from: http://hdl.handle.net/1969.1/4676.

Council of Science Editors:

Rathmann RJ. Effects of conventional or low bull to female ratio and utilization of reproductive tract scores in extensively-managed, natural mating breeding groups. [Masters Thesis]. Texas A&M University; 2007. Available from: http://hdl.handle.net/1969.1/4676

Freie Universität Berlin

10. Araujo Sales de Oliveira, Fabiola. Epidemiology of sexually transmitted diseases, bacterial vaginosis and candidiasis, and occurrence of female genital schistosomiasis in women from rural northeast Brazil.

Degree: 2010, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-8376

► Women of reproductive age are particularly vulnerable to sexually transmitted diseases (STD) due to biological, cultural and gender-specific characteristics. Additionally, ulcerative STD, as well as… (more)

▼ Women of reproductive age are particularly vulnerable to sexually transmitted diseases (STD) due to biological, cultural and gender-specific characteristics. Additionally, ulcerative STD, as well as genital schistosomiasis - a particular form of this parasitic disease - increase the risk of acquiring an HIV infection. The objectives of the present study were to describe the epidemiology of the most important STD (syphilis, gonorrhoea, trichomoniasis, chlamydia and HPV infection) as well as other reproductive tract infections (bacterial vaginosis and candidiasis) in women from rural northeast Brazil, and the prevalence of genital schistosomiasis in this population group. A cross-sectional study in a small municipality in Ceará State was undertaken (girls and women aged 12 to 49 years). After the application of structured questionnaires, participants were examined gynecologically and specimens were collected for laboratory diagnostics. A total of 734 girls and women participated in the study. Among these, 592 (80,7%) had initiated sexual life and were included in the present analysis. At least one STD was found in 112 (19,6%; 95% confidence interval: 16,5%-23,2%) and at least one genital tract infection in 255 participants (44,8%; 40,7%-49,0%). The prevalences of STD were: HPV 11,7% (9,3%-14,7%), chlamydia infection 4,5% (3,0%-6,6%), trichomoniasis 4,1% (2,7%-6,1%), syphilis 0,2% (0,0%-1,1%) and gonorrhoea (1,2%; 0,5%-2,6%). The prevalences of bacterial vaginosis and candidiasis were 20,0% (16,9%-23,6%) and 12,5% (10,0%-15,5%), respectively. There was no case of HIV infection. The most common gynecological complaints were abnormal vaginal discharge in gonorrhoea (85,7%), and lower abdominal pain in trichomoniasis (75,0%). The following variables were independently associated with STD: not knowing if the partner had another partner (adjusted odds ratio: 3,56; 95% confidence interval: 1,09-11,62; p=0,04), three or more partners in life (2,35; 1,32-4,17; p=0,004) and first pregnancy younger than 16 years (2,28; 1,09-4,78; p=0,03). Previous participation in a cervical cancer screening program was protective against STD (0,26; 0,12-0,57; p=0,001). There was no case of genital schistosomiasis: in 401 biopsies and 981 Pap smears no Schistosoma mansoni eggs were found. This study shows that genital infections in women from rural northeast Brazil are common and are associated with different risk factors. The absence of genital schistosomiasis in almost 1000 girls and women from two endemic areas can be explained by the low parasite load in this population. Advisors/Committee Members: n (gender), Prof. Dr. med. Prof. h. c. Hermann Feldmeier (firstReferee), Prof. Dr. med. Gundel Harms-Zwingenberger (furtherReferee), Priv.-Doz. Dr. med. Joachim Richter (furtherReferee).

Subjects/Keywords: epidemiology; sexually transmitted diseases; reproductive tract infections; female genital schistosomiasis; Brazil; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA (6^th Edition):

Araujo Sales de Oliveira, F. (2010). Epidemiology of sexually transmitted diseases, bacterial vaginosis and candidiasis, and occurrence of female genital schistosomiasis in women from rural northeast Brazil. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-8376

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Araujo Sales de Oliveira, Fabiola. “Epidemiology of sexually transmitted diseases, bacterial vaginosis and candidiasis, and occurrence of female genital schistosomiasis in women from rural northeast Brazil.” 2010. Thesis, Freie Universität Berlin. Accessed April 17, 2021. http://dx.doi.org/10.17169/refubium-8376.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Araujo Sales de Oliveira, Fabiola. “Epidemiology of sexually transmitted diseases, bacterial vaginosis and candidiasis, and occurrence of female genital schistosomiasis in women from rural northeast Brazil.” 2010. Web. 17 Apr 2021.

Vancouver:

Araujo Sales de Oliveira F. Epidemiology of sexually transmitted diseases, bacterial vaginosis and candidiasis, and occurrence of female genital schistosomiasis in women from rural northeast Brazil. [Internet] [Thesis]. Freie Universität Berlin; 2010. [cited 2021 Apr 17]. Available from: http://dx.doi.org/10.17169/refubium-8376.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Araujo Sales de Oliveira F. Epidemiology of sexually transmitted diseases, bacterial vaginosis and candidiasis, and occurrence of female genital schistosomiasis in women from rural northeast Brazil. [Thesis]. Freie Universität Berlin; 2010. Available from: http://dx.doi.org/10.17169/refubium-8376

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Edinburgh

11. Frew, Lorraine. The production and function of cervical hCAP18/LL-37 in pregnancy.

Degree: PhD, 2014, University of Edinburgh

URL: http://hdl.handle.net/1842/18000

► Antimicrobial peptides (AMPs) are small proteins produced by epithelial surfaces, which have broad-spectrum antimicrobial and immunomodulatory activities. In the lung, skin and alimentary tract AMPs… (more)

▼ Antimicrobial peptides (AMPs) are small proteins produced by epithelial surfaces, which have broad-spectrum antimicrobial and immunomodulatory activities. In the lung, skin and alimentary tract AMPs are known to be important in infectious and inflammatory conditions. Far less is known regarding the role of AMPs within the female reproductive tract, but as infection and inflammation are causes of preterm labour, AMPs may have a key function in maintain and protecting pregnancy. The major groups of human AMPs include the human beta defensins (HBDs), two antileukoproteinases (secretory leukocyte protease inhibitor (SLPI) and Trappin-2/Elafin), and the human cathelicidin hCAP18/LL-37, with several studies identifying their presence at sites throughout the reproductive tract. The cervix in pregnancy is positioned between the upper genital tract containing the developing fetus and the lower tract where infections usually arise. I hypothesise that AMPs are fundamental to mucosal immune defence of the cervix in pregnancy, preventing ascending infection and excessive inflammation that can cause preterm labour. This thesis focused on the human cathelicidin hCAP18/LL-37 and its role within the cervix and vagina. The aims of this thesis were to; investigate the inflammatory effects of LL-37 from cervical and vaginal derived epithelial cells and determine the pathways and receptors in which LL-37 may elicit its effects and how production may be regulated; investigate the role of CRAMP in a mouse model of preterm birth; and determine the production of AMPs by the pregnant cervix whilst investigating the relationship between AMP concentrations in cervicovaginal secretions and preterm labour. The inflammatory effect of LL-37 was investigated using cell lines derived from endocervical, ectocervical and vaginal epithelium. The study of these cell lines suggests divergent responses of cervical and vaginal epithelial cells. LL-37 mediated induction of IL-8 and IL-6 production from endocervical epithelial cells was observed in a dose-dependent and time-dependent manner, whilst ectocervical and vaginal cells also respond to treatment with LL-37 through IL-8 and IL-6 production. To determine a possible mechanism of action of LL-37 on IL-8 and IL-6 in the three cell lines, inhibitors against MAPK cascades, ERK, p38 MAPK and JNK, and known LL-37 receptors were investigated. In endocervical cells LL-37 mediated IL-8 occurs via activation of unidentified GPCRs, whilst in ectocervical cells this effect on IL‐8 and IL-6 is via the activation of ERK and p38 MAPK cascades. The mechanism by which LL-37 induces IL-8 secretion in vaginal epithelial cells remains unknown. Expression of LL-37 was shown to be mediated by vitamin D3 in vitro in cervical and vaginal epithelial cells. However when this relationship was investigated in vivo, using matched serum and cervicovaginal secretions from woman at early pregnancy, no correlation was observed between circulating vitamin D and cervicovaginal or circulating hCAP18/LL-37. However, the majority of women…

Subjects/Keywords: 618.3; antimicrobial peptides; female reproductive tract; cervix; pregnancy; mucosal immune defence; cathelicidin hCAP18/LL-37; epithelial cells; vaginal epithelium

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APA (6^th Edition):

Frew, L. (2014). The production and function of cervical hCAP18/LL-37 in pregnancy. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/18000

Chicago Manual of Style (16^th Edition):

Frew, Lorraine. “The production and function of cervical hCAP18/LL-37 in pregnancy.” 2014. Doctoral Dissertation, University of Edinburgh. Accessed April 17, 2021. http://hdl.handle.net/1842/18000.

MLA Handbook (7^th Edition):

Frew, Lorraine. “The production and function of cervical hCAP18/LL-37 in pregnancy.” 2014. Web. 17 Apr 2021.

Vancouver:

Frew L. The production and function of cervical hCAP18/LL-37 in pregnancy. [Internet] [Doctoral dissertation]. University of Edinburgh; 2014. [cited 2021 Apr 17]. Available from: http://hdl.handle.net/1842/18000.

Council of Science Editors:

Frew L. The production and function of cervical hCAP18/LL-37 in pregnancy. [Doctoral Dissertation]. University of Edinburgh; 2014. Available from: http://hdl.handle.net/1842/18000

University of Central Florida

12. Eade, Colleen. Characterization Of Innate Immunity In The Female Reproductive Tract For The Prevention Of Hiv Acquisition.

Degree: 2013, University of Central Florida

URL: https://stars.library.ucf.edu/etd/2960

► Human immunodeficiency virus (HIV) infects 30 million people worldwide. In sub-Saharan Africa, the region most affected by HIV, women comprise 60% of the infected population.… (more)

▼ Human immunodeficiency virus (HIV) infects 30 million people worldwide. In sub-Saharan Africa, the region most affected by HIV, women comprise 60% of the infected population. Heterosexual transmission is a major mode of viral acquisition, mandating further research of the process and prevention of HIV acquisition via the female reproductive tract (FRT). The FRT is a dynamic environment, protected by host immune mechanisms and commensal microbes. The disruption of either of these elements can increase susceptibility to HIV. Accordingly, one common risk factor for HIV acquisition is the microbial shift condition known as bacterial vaginosis (BV), which is characterized by the displacement of healthy lactobacilli by an overgrowth of pathogenic bacteria. As the bacteria responsible for BV pathogenicity and their interactions with host immunity are not understood, we sought to evaluate the effects of BV-associated bacteria on reproductive epithelia. Here we have characterized the interaction between BV-associated bacteria and the female reproductive tract by measuring cytokine and defensin induction in FRT epithelial cells following bacterial inoculation. Four BV-associated bacteria were evaluated alongside six lactobacilli for a comparative assessment. Our model showed good agreement with clinical BV trends; we observed a distinct cytokine and human β- defensin-2 response to BV-associated bacteria, especially Atopobium vaginae, compared to most lactobacilli. One lactobacillus species, Lactobacillus vaginalis, induced an immune response similar to that elicited by BV-associated bacteria. These iii data provide an important prioritization of BV-associated bacteria and support further characterization of reproductive bacteria and their interactions with host epithelia. We next evaluated the effect of this interaction on HIV infection by investigating the soluble effectors secreted when FRT epithelial cells were cocultured with A. vaginae. We observed increased proviral activity mediated by secreted low molecular weight effectors, and determined that this activity was not likely mediated by cytokine responses. Instead, we identified a complex mixture containing several upregulated host proteins. Selected individual proteins from the mixture exhibited HIV-enhancing activity only when applied with the complex mixture of proviral factors, suggesting that HIV enhancement might be mediated by synergistic effects. In addition to characterizing the immune interactions that mediate the enhanced HIV acquisition associated with BV, we also evaluated the safety and efficacy of RC- 101, a candidate vaginal microbicide being developed for the prevention of HIV transmission. RC-101 has been effective and well tolerated in preliminary cell culture and macaque models. However, the effect of RC-101 on primary vaginal tissues and resident vaginal microflora requires further evaluation. Here, we treated primary vaginal tissues and vaginal bacteria, both pathogenic and commensal, with RC-101 to investigate compatibility of this microbicide with… Advisors/Committee Members: Cole, Alexander.

Subjects/Keywords: Hiv; bacterial vaginosis; innate immunology; mucosal immunology; female reproductive tract; Molecular Biology; Dissertations, Academic – Graduate Studies, Graduate Studies – Dissertations, Academic

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APA (6^th Edition):

Eade, C. (2013). Characterization Of Innate Immunity In The Female Reproductive Tract For The Prevention Of Hiv Acquisition. (Doctoral Dissertation). University of Central Florida. Retrieved from https://stars.library.ucf.edu/etd/2960

Chicago Manual of Style (16^th Edition):

Eade, Colleen. “Characterization Of Innate Immunity In The Female Reproductive Tract For The Prevention Of Hiv Acquisition.” 2013. Doctoral Dissertation, University of Central Florida. Accessed April 17, 2021. https://stars.library.ucf.edu/etd/2960.

MLA Handbook (7^th Edition):

Eade, Colleen. “Characterization Of Innate Immunity In The Female Reproductive Tract For The Prevention Of Hiv Acquisition.” 2013. Web. 17 Apr 2021.

Vancouver:

Eade C. Characterization Of Innate Immunity In The Female Reproductive Tract For The Prevention Of Hiv Acquisition. [Internet] [Doctoral dissertation]. University of Central Florida; 2013. [cited 2021 Apr 17]. Available from: https://stars.library.ucf.edu/etd/2960.

Council of Science Editors:

Eade C. Characterization Of Innate Immunity In The Female Reproductive Tract For The Prevention Of Hiv Acquisition. [Doctoral Dissertation]. University of Central Florida; 2013. Available from: https://stars.library.ucf.edu/etd/2960

13. 小泉, 雅江. LGR4はマウスにおいて雌生殖器の分化をコントロールする.

Degree: 博士(医学), 2016, Ehime University / 愛媛大学

URL: http://iyokan.lib.ehime-u.ac.jp/dspace/handle/iyokan/4799

博士(医学)

乙医博第421号

Subjects/Keywords: Female reproductive tract; Fetal development; Sex determination; Sex differentiation; Steroid hormones

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APA (6^th Edition):

小泉, �. (2016). LGR4はマウスにおいて雌生殖器の分化をコントロールする. (Thesis). Ehime University / 愛媛大学. Retrieved from http://iyokan.lib.ehime-u.ac.jp/dspace/handle/iyokan/4799

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

小泉, 雅江. “LGR4はマウスにおいて雌生殖器の分化をコントロールする.” 2016. Thesis, Ehime University / 愛媛大学. Accessed April 17, 2021. http://iyokan.lib.ehime-u.ac.jp/dspace/handle/iyokan/4799.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

小泉, 雅江. “LGR4はマウスにおいて雌生殖器の分化をコントロールする.” 2016. Web. 17 Apr 2021.

Vancouver:

小泉 �. LGR4はマウスにおいて雌生殖器の分化をコントロールする. [Internet] [Thesis]. Ehime University / 愛媛大学; 2016. [cited 2021 Apr 17]. Available from: http://iyokan.lib.ehime-u.ac.jp/dspace/handle/iyokan/4799.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

小泉 �. LGR4はマウスにおいて雌生殖器の分化をコントロールする. [Thesis]. Ehime University / 愛媛大学; 2016. Available from: http://iyokan.lib.ehime-u.ac.jp/dspace/handle/iyokan/4799

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

14. Dixon, Rose E. The Role of Interstitial Cells of Cajal in Oviduct Pacemaker Activity.

Degree: 2009, University of Nevada – Reno

URL: http://hdl.handle.net/11714/4133

► The experiments described in this dissertation were performed to investigate the spontaneous electrical activity of the oviduct myosalpinx and to determine its cellular origin and… (more)

▼ The experiments described in this dissertation were performed to investigate the spontaneous electrical activity of the oviduct myosalpinx and to determine its cellular origin and ionic basis. We have also examined the impact of chlamydia on this activity, using a murine model of genital chlamydia infection. In vitro spatio-temporal mapping and video imaging of myosalpinx contractions and egg and luminal particle movement within the oviduct have revealed that spontaneous myosalpinx contractions are critical for egg transport along the duct, not ciliary beating. Intracellular microelectrode recordings and simultaneous isometric force recordings have shown that slow waves provide the electrical basis for the rhythmic contractions of the myosalpinx. Immunohistochemistry against the KIT protein has revealed an extensive network of ICC-OVI along the length of oviducts. Organotypic culture experiments performed on P0 oviducts incubated with or without the KIT neutralizing antibody ACK2, have shown that slow wave activity is absent from oviducts with severely disrupted ICC-OVI networks, revealing for the first time, that ICC-OVI are the pacemakers of the oviduct. RT-PCR has revealed transcriptional expression of several Ca2+ and K+ channels as well as ClCa channels (encoded by Tmem16a) in the oviduct myosalpinx. The ionic basis of slow wave activity has been thoroughly examined using intracellular electrophysiology and specific ion channel agonists and antagonists. Adequate extracellular Ca2+ and intact intracellular Ca2+ stores have been found to be critical for pacemaker activity. ClCa channel activity has also been determined to be essential for ii pacemaker activity, since slow waves are absent from oviducts exposed to the ClCa channel antagonist niflumic acid and from oviducts taken from animals that are homozygotes for the null allele of TMEM16A. TREK, KATP and Kv channels are regulators of slow wave frequency. These three channels along with IK, have all been found to contribute to the setting of the RMP in the oviduct. Caffeine has been demonstrated to activate KATP channels in a cAMP-dependent manner in the oviduct. This causes membrane hyperpolarization, inhibition of slow wave activity and loss of myosalpinx contractions and may explain why women with high caffeine intakes take longer to conceive than women who do not consume caffeine. In oviducts 2 wk post-infection with C. muridarum, slow wave activity has been found to be absent and ICC-OVI populations were severely disrupted or absent. Damage to pacemaker activity is suggested to be a result of the host immune response to infection, more specifically to the upregulation of proinflammatory mediators NOS2 and PTGS2. Pacemaker activity can be protected from LPS induced inflammatory damage in vitro by inhibition of NOS2 with 1400W. ICC-OVI networks begin to recover or re-establish and pacemaker activity returns as the infection is resolved, 4 - 7 weeks post-infection. In conclusion, this dissertation provides compelling… Advisors/Committee Members: Ward, Sean M. (advisor), Sanders, Kenton M. (committee member), Koh, Sang D. (committee member), Leblanc, Normand (committee member), Kidd, Thomas (committee member).

Subjects/Keywords: Chlamydia; Fallopian tubes; Female reproductive tract; Interstitial cells of Cajal; Oviduct; Smooth muscle

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APA (6^th Edition):

Dixon, R. E. (2009). The Role of Interstitial Cells of Cajal in Oviduct Pacemaker Activity. (Thesis). University of Nevada – Reno. Retrieved from http://hdl.handle.net/11714/4133

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Dixon, Rose E. “The Role of Interstitial Cells of Cajal in Oviduct Pacemaker Activity.” 2009. Thesis, University of Nevada – Reno. Accessed April 17, 2021. http://hdl.handle.net/11714/4133.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Dixon, Rose E. “The Role of Interstitial Cells of Cajal in Oviduct Pacemaker Activity.” 2009. Web. 17 Apr 2021.

Vancouver:

Dixon RE. The Role of Interstitial Cells of Cajal in Oviduct Pacemaker Activity. [Internet] [Thesis]. University of Nevada – Reno; 2009. [cited 2021 Apr 17]. Available from: http://hdl.handle.net/11714/4133.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Dixon RE. The Role of Interstitial Cells of Cajal in Oviduct Pacemaker Activity. [Thesis]. University of Nevada – Reno; 2009. Available from: http://hdl.handle.net/11714/4133

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

15. Cristhiane Valério Garabello Pires. Prevalência de infecções genitais em mulheres com deficiência física por lesão medular.

Degree: 2015, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/5/5139/tde-27012016-101516/

►

Além da deficiência física, a diminuição ou perda da sensibilidade geniturinária é um dos maiores impactos para mulheres com Lesão Medular (LM). Devido à perda… (more)

▼

Além da deficiência física, a diminuição ou perda da sensibilidade geniturinária é um dos maiores impactos para mulheres com Lesão Medular (LM). Devido à perda da mobilidade funcional e as barreiras arquitetônicas, estas muitas vezes não tem acesso aos cuidados adequados para a saúde ginecológica. Como aproximadamente 80% das lesões da medula espinal acometem indivíduos do sexo masculino, os estudos raramente focam as necessidades e questões referentes às mulheres. Objetivo: Avaliar a prevalência de infecções genitais não virais em mulheres com deficiência física por lesão medular, comparativamente às mulheres saudáveis Método: Estudo de corte transversal, caso controle. Foram estudadas 52 mulheres com LM (grupo estudo) e 57 mulheres saudáveis (grupo controle). Todas responderam a um questionário estruturado e foram submetidas à coleta de conteúdo vaginal para pesquisa de Trichomonas vaginalis e leveduras, bacterioscopia com coloração pelo método Gram, cultura geral (meio ágar sangue), cultura para fungos (meio Sabouraud) e coleta de conteúdo endocervical para pesquisa de Chlamydia trachomatis e Neisseria gonorrhorae (reação em cadeia da polimerase) e cultura para Mycoplasmas sp (meios U9, A7). Resultados: As mulheres com lesão medular, comparativamente ao grupo controle, apresentaram maior frequência de Candida sp no exame micológico direto (p= 0,017); entretanto não foi observada diferença estatisticamente significativa na frequência de isolamento de espécies fúngicas entre os grupos. O grupo estudo apresentou maior frequência de isolamento de Escherichia coli (p= 0,002) e de Corynebacterium sp (p= 0,023) e menor frequência de Lactobacillus sp (p < 0,001) em conteúdo vaginal. Em ambos os grupos não foram encontrados casos positivos para Trichomonas vaginalis. A avaliação do escore de Nugent para diagnóstico de vaginose bacteriana demonstrou maior freqüência de flora intermediária (Nugent 4-7) no grupo estudo (p= 0,039). As pesquisas de Chlamydia trachomatis e Neisseria gonorroheae foram negativas em todas as mulheres. Com relação ao isolamento de Mycoplasmas sp, os resultados foram semelhantes em ambos os grupos. Conclusão: A menor freqüência de isolamento de Lactobacillus sp e a maior freqüência de isolamento de Corynebacterium sp e de Escherichia coli na vagina em mulheres com LM, assim como a elevada frequência de flora intermediária pelo escore de Nugent verificada nas mesmas, fortemente sugerem um desequilíbrio da microbiota vaginal, diferente de uma flora dominada por Lactobacillus sp em tais mulheres. Desde que os Lactobacillus sp são essenciais para a manutenção da flora vaginal e a inibição do crescimento de outras bactérias, sua ausência relativa em mulheres com LM pode influenciar a ocorrência de infecções do trato urogenital. Adicionalmente, a mais elevada frequência de detecção de fungos pela microscopia em mulheres com LM sugere que estas podem albergar uma maior concentração vaginal desses microorganismos do que outras mulheres

Besides their physical disability, decreased or absent…

Advisors/Committee Members: Iara Moreno Linhares, Nilson Roberto de Melo, Neila Maria de Góis Speck.

Subjects/Keywords: Doenças dos genitais femininos; Infecções do sistema genital; Mulheres; Saúde da mulher; Traumatismos da medula espinal; Genital diseases female; Reproductive tract infections; Spinal cord injuries; Women; Women's health

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APA (6^th Edition):

Pires, C. V. G. (2015). Prevalência de infecções genitais em mulheres com deficiência física por lesão medular. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/5/5139/tde-27012016-101516/

Chicago Manual of Style (16^th Edition):

Pires, Cristhiane Valério Garabello. “Prevalência de infecções genitais em mulheres com deficiência física por lesão medular.” 2015. Masters Thesis, University of São Paulo. Accessed April 17, 2021. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-27012016-101516/.

MLA Handbook (7^th Edition):

Pires, Cristhiane Valério Garabello. “Prevalência de infecções genitais em mulheres com deficiência física por lesão medular.” 2015. Web. 17 Apr 2021.

Vancouver:

Pires CVG. Prevalência de infecções genitais em mulheres com deficiência física por lesão medular. [Internet] [Masters thesis]. University of São Paulo; 2015. [cited 2021 Apr 17]. Available from: http://www.teses.usp.br/teses/disponiveis/5/5139/tde-27012016-101516/.

Council of Science Editors:

Pires CVG. Prevalência de infecções genitais em mulheres com deficiência física por lesão medular. [Masters Thesis]. University of São Paulo; 2015. Available from: http://www.teses.usp.br/teses/disponiveis/5/5139/tde-27012016-101516/

University of Florida

16. Matter, John Martin, 1959-. Factors associated with sperm motility and storage in a squamate reptile, Scelopours jarrovi.

Degree: PhD, Zoology, 1996, University of Florida

URL: https://ufdc.ufl.edu/AA00009010

Subjects/Keywords: Androgens; Epididymis; Female animals; Lizards; Mating behavior; Reproductive tract infections; Reptiles; Snakes; Spermatozoa; Testes; Sceloporus – Physiology; Sceloporus – Reproduction

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APA (6^th Edition):

Matter, John Martin, 1. (1996). Factors associated with sperm motility and storage in a squamate reptile, Scelopours jarrovi. (Doctoral Dissertation). University of Florida. Retrieved from https://ufdc.ufl.edu/AA00009010

Chicago Manual of Style (16^th Edition):

Matter, John Martin, 1959-. “Factors associated with sperm motility and storage in a squamate reptile, Scelopours jarrovi.” 1996. Doctoral Dissertation, University of Florida. Accessed April 17, 2021. https://ufdc.ufl.edu/AA00009010.

MLA Handbook (7^th Edition):

Matter, John Martin, 1959-. “Factors associated with sperm motility and storage in a squamate reptile, Scelopours jarrovi.” 1996. Web. 17 Apr 2021.

Vancouver:

Matter, John Martin 1. Factors associated with sperm motility and storage in a squamate reptile, Scelopours jarrovi. [Internet] [Doctoral dissertation]. University of Florida; 1996. [cited 2021 Apr 17]. Available from: https://ufdc.ufl.edu/AA00009010.

Council of Science Editors:

Matter, John Martin 1. Factors associated with sperm motility and storage in a squamate reptile, Scelopours jarrovi. [Doctoral Dissertation]. University of Florida; 1996. Available from: https://ufdc.ufl.edu/AA00009010

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Open Access Theses and Dissertations