subject:(endocrinology)

Boston University

1. Segal, Amanda Rachel. Iodine status of pregnant Haitian-American women.

Degree: MS, Medical Sciences, 2014, Boston University

► Iodine is an essential element for the production of thyroid hormone, which is required for fetal cognitive development during pregnancy. Changes in maternal metabolism and… (more)

Subjects/Keywords: Endocrinology

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APA (6^th Edition):

Segal, A. R. (2014). Iodine status of pregnant Haitian-American women. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/15359

Chicago Manual of Style (16^th Edition):

Segal, Amanda Rachel. “Iodine status of pregnant Haitian-American women.” 2014. Masters Thesis, Boston University. Accessed January 18, 2021. http://hdl.handle.net/2144/15359.

MLA Handbook (7^th Edition):

Segal, Amanda Rachel. “Iodine status of pregnant Haitian-American women.” 2014. Web. 18 Jan 2021.

Vancouver:

Segal AR. Iodine status of pregnant Haitian-American women. [Internet] [Masters thesis]. Boston University; 2014. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/2144/15359.

Council of Science Editors:

Segal AR. Iodine status of pregnant Haitian-American women. [Masters Thesis]. Boston University; 2014. Available from: http://hdl.handle.net/2144/15359

Boston University

2. Matos, Cynara. The mechanism of action of MKRN3 and its implication in central precocious puberty.

Degree: MS, Medical Sciences, 2020, Boston University

URL: http://hdl.handle.net/2144/41293

► BACKGROUND: MKRN3 is a gene recently identified to encode the first known inhibitor of puberty initiation. MKRN3 mutations have been identified in children diagnosed with… (more)

▼ BACKGROUND: MKRN3 is a gene recently identified to encode the first known inhibitor of puberty initiation. MKRN3 mutations have been identified in children diagnosed with familial central precocious puberty. MKRN3 is a maternally imprinted gene; only the father’s allele is expressed by the child. Family studies and patterns of inheritance affirm that mutant alleles only result in CPP when the mutation was inherited from the father. Although mutations in MKRN3 were found to have implications in development of central precocious puberty, its mechanism of action remains a mystery. Previous studies in our laboratory have focused on MKRN3’s function as an E3 ubiquitin ligase and thus sought to investigate its potential targets in the cell. Because kisspeptin is the most potent known activator of GnRH neurons, it seemed to be the most likely candidate. Despite efforts to identify an association between kisspeptin levels and MKRN3 expression, little headway has been made. OBJECTIVE: Beyond the most common known function of E3 ubiquitin ligases in protein degradation, increasing evidence suggests that E3 ubiquitin ligases contribute to aiding human brain development throughout childhood and into adolescence. This proposed action of E3 ubiquitin ligases led us to propose a role for MKRN3 as a potential regulator of GnRH neuronal plasticity and maturation. I hypothesized that MKRN3 plays a role in delaying GnRH neuronal maturation and neuronal plasticity until puberty onset. Thus, MKRN3 deficiency would result in premature GnRH neuron maturation. METHODS: A mouse model of Mkrn3 knockout mice (Mkrn3 +/p-) was compared to wildtype mice (Mkrn3+/+). Using DAB IHC, GnRH neurons in the rostral pre-optic area (rPOA) area were labeled and morphologically analyzed. Additionally, Golgi staining of neurons in the arcuate nucleus was done to visualize details of neuronal synapses. Neurons were visualized under 40X and 100X magnification. To visualize spines, confocal images of dendrites from Mkrn3+/p- and Mkrn3+/+ mice were captured. Images were visualized and analyzed using both ImageJ and NeuronStudio software (for spine analysis only). RESULTS: Initial morphological analysis of GnRH neurons failed to show any significant effect of the Mkrn3 genotype on dendrite arrangement, varying among complex, bipolar, and unipolar. Similarly, Golgi staining analysis revealed that the Mkrn3 genotype did not have a measurable effect on dendritic spine type percentages. Mkrn3+/p- and Mkrn3+/+ mice showed no apparent difference in the percentage of stubby, thin, and mushroom shaped spines. However, Mkrn3 deficiency did show an effect on spine density, with neurons from the arcuate nucleus of the hypothalamus of Mkrn3+/p- mice having an increased total number of dendritic spines compared to neurons from wildtype mice. CONCLUSIONS: Mkrn3 does not appear to have an effect on dendrite architecture of GnRH neurons nor change in spine type of arcuate nucleus neurons. However, the Mkrn3 genotype does seem to affect neuronal spine density, at least in… Advisors/Committee Members: Moussavi, Mina (advisor).

Subjects/Keywords: Endocrinology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Matos, C. (2020). The mechanism of action of MKRN3 and its implication in central precocious puberty. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/41293

Chicago Manual of Style (16^th Edition):

Matos, Cynara. “The mechanism of action of MKRN3 and its implication in central precocious puberty.” 2020. Masters Thesis, Boston University. Accessed January 18, 2021. http://hdl.handle.net/2144/41293.

MLA Handbook (7^th Edition):

Matos, Cynara. “The mechanism of action of MKRN3 and its implication in central precocious puberty.” 2020. Web. 18 Jan 2021.

Vancouver:

Matos C. The mechanism of action of MKRN3 and its implication in central precocious puberty. [Internet] [Masters thesis]. Boston University; 2020. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/2144/41293.

Council of Science Editors:

Matos C. The mechanism of action of MKRN3 and its implication in central precocious puberty. [Masters Thesis]. Boston University; 2020. Available from: http://hdl.handle.net/2144/41293

Boston University

3. Bapatla, Neha. An evaluation and comparison of current FDA-approved treatments for obesity.

Degree: MS, Medical Sciences, 2018, Boston University

URL: http://hdl.handle.net/2144/30872

► As society adopts a sedentary lifestyle coupled with increased energy intake, obesity continues to spread pervasively throughout the world. It poses a strong public health… (more)

▼ As society adopts a sedentary lifestyle coupled with increased energy intake, obesity continues to spread pervasively throughout the world. It poses a strong public health threat due to the development of related comorbidities in individuals, such as diabetes, hypertension, dyslipidemia, and obstructive sleep apnea. Prior to the new millennium, treatment of obesity included lifestyle modifications or bariatric surgery. However, this alienated a large subset of the population who were unable to lose weight with behavioral changes alone but not obese enough to qualify for bariatric surgery. Thus, the need for an intermediate therapeutic method existed. Short-term pharmacotherapy, such as orlistat, was developed as a potential treatment option for weight loss. However, as the years passed, scientists began targeting the central nervous system (CNS) and gastrointestinal systems to develop long-term medications. As a result, liraglutide, lorcaserin, naltrexone/bupropion extended-release, and phentermine/ topiramate extended-release became FDA-approved for long-term treatment of obesity. Each drug acts on a specific part of the CNS to modulate appetite and cause decreased food intake in patients. Clinical trials conducted on these medications found phentermine/topiramate extended-release to cause the greatest weight loss. However, none of the medications emerged as a first-line treatment option for weight loss. With a myriad of side effects and contraindications, clinicians must practice personalized medicine to prescribe certain drugs for patients. Furthermore, because these medications have been relatively recently approved, research on long-term effects of these medications on the human body is not available. Despite this, the emergence of pharmacotherapy in conjunction with lifestyle modifications in treating obesity has been positive. It has created a necessary step in the direction of reducing obesity prevalence worldwide and thus a proactive step in promoting the health of individuals. Advisors/Committee Members: Offner, Gwynneth (advisor), Spencer, Jean (advisor).

Subjects/Keywords: Endocrinology

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APA (6^th Edition):

Bapatla, N. (2018). An evaluation and comparison of current FDA-approved treatments for obesity. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/30872

Chicago Manual of Style (16^th Edition):

Bapatla, Neha. “An evaluation and comparison of current FDA-approved treatments for obesity.” 2018. Masters Thesis, Boston University. Accessed January 18, 2021. http://hdl.handle.net/2144/30872.

MLA Handbook (7^th Edition):

Bapatla, Neha. “An evaluation and comparison of current FDA-approved treatments for obesity.” 2018. Web. 18 Jan 2021.

Vancouver:

Bapatla N. An evaluation and comparison of current FDA-approved treatments for obesity. [Internet] [Masters thesis]. Boston University; 2018. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/2144/30872.

Council of Science Editors:

Bapatla N. An evaluation and comparison of current FDA-approved treatments for obesity. [Masters Thesis]. Boston University; 2018. Available from: http://hdl.handle.net/2144/30872

Boston University

4. Allen, Ronald Wayne. Fatty acid required for glucose-induced change in beta cell plasma membrane potential leading to insulin secretion.

Degree: MS, Nutrition and Metabolism, 2019, Boston University

URL: http://hdl.handle.net/2144/34890

► The pancreatic β−cell secretes insulin through a combination of triggering and amplification pathways in response to glucose. Glucose metabolism is known to increase intracellular calcium… (more)

▼ The pancreatic β−cell secretes insulin through a combination of triggering and amplification pathways in response to glucose. Glucose metabolism is known to increase intracellular calcium and trigger insulin secretion from the β−cell while fatty acid (FA), an essential component of glucose stimulated insulin secretion (GSIS), is known to amplify secretion through varied mechanisms. Orlistat, a lipase inhibitor, blocks GSIS although the mechanism has not been clearly elucidated. We show that orlistat can also inhibit basal insulin secretion. FA can prevent/reverse orlistat-induced inhibition of secretion but fails to amplify GSIS after orlistat treatment. Here we test the hypothesis that FA is required to maintain normal plasma membrane potential and calcium influx in the β−cell. Clonal pancreatic β−cells (INS-1 832/13) were cultured in RPMI media containing 11 mM glucose and 10% FBS. Insulin secretion was measured over 2 hours with and without FA and orlistat (200 µM) using homogeneous time resolved fluorescence insulin assay (HTRF, Cisbio) and reported as ng/million cells. Intracellular calcium was measured in single cells using fura-2 AM. Single cell membrane potential was measured with virally expressed ARC Lite protein (Montana molecular). High glucose (8 mM) stimulated insulin secretion at least 3-fold over basal glucose (2 mM) and addition of FA enhanced GSIS. Orlistat almost completely abolished GSIS. This inhibition was mostly prevented in the presence of FA. Orlistat blocked calcium influx required for triggering insulin release while addition of FA recovered normal calcium homeostasis. The monoacylglycerol lipase inhibitor JZL 184 reduced both calcium influx and the increase in plasma membrane potential induced by KCl. FA recovered plasma membrane potential inhibited by JZL 184. Our results suggest that reducing β−cell intracellular FA availability by lipase inhibition blocks GSIS by preventing the glucose-induced rise in plasma membrane potential required to induce β−cell calcium influx through voltage dependent calcium channels (VDCC). FA is thus required to maintain normal nutrient metabolic coupling to insulin secretion. Whether the effect of FA to modulate plasma membrane potential plays a role in β−cell insulin hypersecretion resulting from excess nutrients requires further investigation. Advisors/Committee Members: Corkey, Barbara E. (advisor), Deeney, Jude T. (advisor).

Subjects/Keywords: Endocrinology

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APA (6^th Edition):

Allen, R. W. (2019). Fatty acid required for glucose-induced change in beta cell plasma membrane potential leading to insulin secretion. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/34890

Chicago Manual of Style (16^th Edition):

Allen, Ronald Wayne. “Fatty acid required for glucose-induced change in beta cell plasma membrane potential leading to insulin secretion.” 2019. Masters Thesis, Boston University. Accessed January 18, 2021. http://hdl.handle.net/2144/34890.

MLA Handbook (7^th Edition):

Allen, Ronald Wayne. “Fatty acid required for glucose-induced change in beta cell plasma membrane potential leading to insulin secretion.” 2019. Web. 18 Jan 2021.

Vancouver:

Allen RW. Fatty acid required for glucose-induced change in beta cell plasma membrane potential leading to insulin secretion. [Internet] [Masters thesis]. Boston University; 2019. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/2144/34890.

Council of Science Editors:

Allen RW. Fatty acid required for glucose-induced change in beta cell plasma membrane potential leading to insulin secretion. [Masters Thesis]. Boston University; 2019. Available from: http://hdl.handle.net/2144/34890

University of Pennsylvania

5. Cannon, Corey Elizabeth. Maintaining Glucose Homeostasis in Response to Aging and Stress: The Role of Pcif1, Bmi1, and Pdx1.

Degree: 2014, University of Pennsylvania

URL: https://repository.upenn.edu/edissertations/1223

► A sufficient number of functioning beta cells is necessary for maintaining glucose homeostasis. Reduction of beta cell mass or function leads to diabetes. Investigation into… (more)

▼ A sufficient number of functioning beta cells is necessary for maintaining glucose homeostasis. Reduction of beta cell mass or function leads to diabetes. Investigation into the maintenance of both beta cell mass and function is important for the development of therapies to prevent and/or restore functional beta cells. Here, the networks surrounding three proteins in the beta cell, Pcif1, Bmi1, and Pdx1, were studied as they relate to beta cell function and number. The Polycomb protein, Bmi1, has been shown to influence beta cell replication via epigenetic repression of the Ink4a/Arf locus, resulting in suppression of p16 protein translation. The adapter protein, Pcif1, facilitates the ubiquitination of Bmi1 and influences beta cell replication, as Pcif1 heterogyzous mice have increased rates of beta cell proliferation. I hypothesized that Pcif1 regulates beta cell proliferation through a Bmi1-dependent mechanism. Analysis of Pcif1 heterozygous islets revealed that p16 protein levels were indistinguishable from controls, thus making a p16-dependent mechanism unlikely. Further investigation of Bmi1 targets may reveal another pathway by which Pcif1 and Bmi1 influence beta cell replication. The role of Bmi1 has not been well-described in adult animals. Analysis of Bmi1 heterozygous animals revealed increased insulin sensitivity, as compared to wildtype. This was found to be due to an enhancement of Akt phosphorylation, with the upstream insulin signaling pathway unaffected. Bmi1 also appears to play a role in the development of insulin resistance, as Bmi1 levels are high in insulin-resistant animals. I also began to explore the possibility that the action of Pcif1 on Bmi1 is responsible for the role Bmi1 plays in insulin signaling. The transcription factor, Pdx1, regulates numerous processes specific to the beta cell, including multiple pathways regulating translation. Pdx1 levels have been shown to affect the ability of beta cells to respond to ER stress. A global analysis of translational efficiencies using the TRAP methodology indicated that Pdx1 activity may result in repression of translation of some transcripts. Further analysis of these transcripts will help determine how Pdx1 regulates the translatome of the beta cell and, potentially, how Pdx1 influences the beta cell stress response.

Subjects/Keywords: Endocrinology; Endocrinology, Diabetes, and Metabolism

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APA (6^th Edition):

Cannon, C. E. (2014). Maintaining Glucose Homeostasis in Response to Aging and Stress: The Role of Pcif1, Bmi1, and Pdx1. (Thesis). University of Pennsylvania. Retrieved from https://repository.upenn.edu/edissertations/1223

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Cannon, Corey Elizabeth. “Maintaining Glucose Homeostasis in Response to Aging and Stress: The Role of Pcif1, Bmi1, and Pdx1.” 2014. Thesis, University of Pennsylvania. Accessed January 18, 2021. https://repository.upenn.edu/edissertations/1223.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Cannon, Corey Elizabeth. “Maintaining Glucose Homeostasis in Response to Aging and Stress: The Role of Pcif1, Bmi1, and Pdx1.” 2014. Web. 18 Jan 2021.

Vancouver:

Cannon CE. Maintaining Glucose Homeostasis in Response to Aging and Stress: The Role of Pcif1, Bmi1, and Pdx1. [Internet] [Thesis]. University of Pennsylvania; 2014. [cited 2021 Jan 18]. Available from: https://repository.upenn.edu/edissertations/1223.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cannon CE. Maintaining Glucose Homeostasis in Response to Aging and Stress: The Role of Pcif1, Bmi1, and Pdx1. [Thesis]. University of Pennsylvania; 2014. Available from: https://repository.upenn.edu/edissertations/1223

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

6. Long, Nathan P. Tamoxifen and ICI 182,780 activate GPER-1 in orphanin FQ neurons to facilitate sexual receptivity in female rats.

Degree: 2016, California State University, Long Beach

URL: http://pqdtopen.proquest.com/#viewpdf?dispub=10142967

► Infusion of 17β-estradiol into the arcuate nucleus of the hypothalamus (ARH) 47.5 hours after estrogen benzoate (EB) priming rapidly facilitates sexual receptivity (lordosis) via… (more)

Subjects/Keywords: Neurosciences; Endocrinology

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APA (6^th Edition):

Long, N. P. (2016). Tamoxifen and ICI 182,780 activate GPER-1 in orphanin FQ neurons to facilitate sexual receptivity in female rats. (Thesis). California State University, Long Beach. Retrieved from http://pqdtopen.proquest.com/#viewpdf?dispub=10142967

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Long, Nathan P. “Tamoxifen and ICI 182,780 activate GPER-1 in orphanin FQ neurons to facilitate sexual receptivity in female rats.” 2016. Thesis, California State University, Long Beach. Accessed January 18, 2021. http://pqdtopen.proquest.com/#viewpdf?dispub=10142967.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Long, Nathan P. “Tamoxifen and ICI 182,780 activate GPER-1 in orphanin FQ neurons to facilitate sexual receptivity in female rats.” 2016. Web. 18 Jan 2021.

Vancouver:

Long NP. Tamoxifen and ICI 182,780 activate GPER-1 in orphanin FQ neurons to facilitate sexual receptivity in female rats. [Internet] [Thesis]. California State University, Long Beach; 2016. [cited 2021 Jan 18]. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=10142967.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Long NP. Tamoxifen and ICI 182,780 activate GPER-1 in orphanin FQ neurons to facilitate sexual receptivity in female rats. [Thesis]. California State University, Long Beach; 2016. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=10142967

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Tulane University

7. King-Bailey, Gillian. The behavior and endocrinology of dominance in female white-faced capuchins (Cebus capucinus imitator) in Sector Santa Rosa, Área de Conservación Guanacaste, Costa Rica.

Degree: 2001, Tulane University

URL: https://digitallibrary.tulane.edu/islandora/object/tulane:89673

►

[email protected]

The relationship between behavior, hormones and the environment has long been of interest to evolutionary biologists and biological anthropologists. Hormone levels vary between individuals,… (more)

▼

[email protected]

The relationship between behavior, hormones and the environment has long been of interest to evolutionary biologists and biological anthropologists. Hormone levels vary between individuals, seasonally, and affect behavior. Research in male mammals shows dominance rank is related to androgen and cortisol levels, both of which vary with breeding season. However, even though females also produce androgens and they play a crucial role in regulating the female reproductive system, the role of androgens in the behavior of females is not well understood. White-faced capuchins (Cebus capucinus imitator) are female philopatric, medium-sized Neotropical monkeys. We characterize dominance in female white-faced capuchins, examine how rates of agonism vary with social and environmental change, and investigate the hormonal underpinnings of behavior in Sector Santa Rosa, Área de Conservación Guanacaste, Costa Rica. We find that females demonstrate only moderately linear dominance hierarchies, likely due to high kin-relatedness between females. We determined nearly the same hierarchy despite the methodology used to determine the rank order. Rates of agonism varied with dominance rank and fruit availability and we suggest that females inherit their rank from their mother, but use agonism to maintain this rank throughout their lives. Females adjust their rates of agonism such that they exhibit greater rates of agonism when ripe fruit availability is low. We propose that females need to increase agonism in order to gain access to sufficient resources to sustain themselves and their reproductive requirements. We also suggest that higher fruit availability leads to fewer bouts of agonism because there is enough fruit to occupy most group members. Higher-ranking females exhibit higher androgen and cortisol levels. This is inconsistent with the dual-hormone hypothesis, which suggests that higher-ranking individuals have higher androgen, but lower cortisol levels. It is possible that the threat of male takeovers leads to higher stress and thus higher levels of cortisol as the threat of infanticide remains present. Androgen and cortisol levels did not vary seasonally with fruit availability. This work advances our understanding of the relationship of behavior, hormone levels and environmental changes and is especially important for a growing understanding of androgens in female primates.

1

Gillian Louisa King-Bailey

Advisors/Committee Members: Jack, Katharine (Thesis advisor), School of Liberal Arts Anthropology (Degree granting institution).

Subjects/Keywords: Endocrinology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

King-Bailey, G. (2001). The behavior and endocrinology of dominance in female white-faced capuchins (Cebus capucinus imitator) in Sector Santa Rosa, Área de Conservación Guanacaste, Costa Rica. (Thesis). Tulane University. Retrieved from https://digitallibrary.tulane.edu/islandora/object/tulane:89673

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

King-Bailey, Gillian. “The behavior and endocrinology of dominance in female white-faced capuchins (Cebus capucinus imitator) in Sector Santa Rosa, Área de Conservación Guanacaste, Costa Rica.” 2001. Thesis, Tulane University. Accessed January 18, 2021. https://digitallibrary.tulane.edu/islandora/object/tulane:89673.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

King-Bailey, Gillian. “The behavior and endocrinology of dominance in female white-faced capuchins (Cebus capucinus imitator) in Sector Santa Rosa, Área de Conservación Guanacaste, Costa Rica.” 2001. Web. 18 Jan 2021.

Vancouver:

King-Bailey G. The behavior and endocrinology of dominance in female white-faced capuchins (Cebus capucinus imitator) in Sector Santa Rosa, Área de Conservación Guanacaste, Costa Rica. [Internet] [Thesis]. Tulane University; 2001. [cited 2021 Jan 18]. Available from: https://digitallibrary.tulane.edu/islandora/object/tulane:89673.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

King-Bailey G. The behavior and endocrinology of dominance in female white-faced capuchins (Cebus capucinus imitator) in Sector Santa Rosa, Área de Conservación Guanacaste, Costa Rica. [Thesis]. Tulane University; 2001. Available from: https://digitallibrary.tulane.edu/islandora/object/tulane:89673

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Loyola University Chicago

8. Flaws, Jodi. The Magnetic Separation of Rat Anterior Pituitary Cells.

Degree: MS, Biology, 1989, Loyola University Chicago

URL: https://ecommons.luc.edu/luc_theses/3874

Subjects/Keywords: Endocrinology

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APA (6^th Edition):

Flaws, J. (1989). The Magnetic Separation of Rat Anterior Pituitary Cells. (Thesis). Loyola University Chicago. Retrieved from https://ecommons.luc.edu/luc_theses/3874

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Flaws, Jodi. “The Magnetic Separation of Rat Anterior Pituitary Cells.” 1989. Thesis, Loyola University Chicago. Accessed January 18, 2021. https://ecommons.luc.edu/luc_theses/3874.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Flaws, Jodi. “The Magnetic Separation of Rat Anterior Pituitary Cells.” 1989. Web. 18 Jan 2021.

Vancouver:

Flaws J. The Magnetic Separation of Rat Anterior Pituitary Cells. [Internet] [Thesis]. Loyola University Chicago; 1989. [cited 2021 Jan 18]. Available from: https://ecommons.luc.edu/luc_theses/3874.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Flaws J. The Magnetic Separation of Rat Anterior Pituitary Cells. [Thesis]. Loyola University Chicago; 1989. Available from: https://ecommons.luc.edu/luc_theses/3874

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Boston University

9. Vrolyk, Michael. Testosterone replacement therapy.

Degree: MS, Medical Sciences, 2015, Boston University

URL: http://hdl.handle.net/2144/16024

► Physicians and scientists have suspected that the testes secrete a substance into the body that causes male secondary sexual characteristics for hundreds of years. However,… (more)

▼ Physicians and scientists have suspected that the testes secrete a substance into the body that causes male secondary sexual characteristics for hundreds of years. However, testosterone was not synthesized until 1935 and it was not until the 1940's when scientists could accurately measure the amount of this hormone in the blood. Since then, scientists have been able to make correlations between the levels of testosterone in the body and men's health Scientists have long observed higher levels of testosterone to be associated with an increase in levels of Hematocrit (Hct). As a result, Testosterone Replacement Therapy (TRT) has been used to treat anemia associated with chronic diseases. In recent years, prescription sales for testosterone have sky rocketed due to new clinical uses such as androgen deficiency in older men. In fact, the rate of prescription for testosterone products has increased by over 170% in the previous five years. Long-term data shows that the level of testosterone in the male body begins to decrease at about the age of 30. As the life expectancy of the general population continues to increase, TRT may be a viable option for older men with low testosterone to increase the quality and duration of life. However, an increase in Hct continues to be a major side effect of TRT. New research is beginning to make clear the mechanism by which testosterone affects erythropoeisis. New research suggests TRT suppresses hepcidin and leads to an increase in the rate of iron (Fe) retention in red blood cells (RBCs). Inter-individual differences in the pharmacogenetic effects of TRT have been observed. In the future TRT could be genetically tailored based on the individuals DNA. In this case, the optimal dose of testosterone can be given to maximize benefits and reduce side effects. Here, the risks and benefits associated with TRT and a review of the updated Clinical Guidelines for its use will be presented. The effects of TRT on erythropoeisis will be investigated via a review of the literature. The main objective of this review is to provide a general understanding of TRT and a major side effect of its use, excessive erythropoeisis.

Subjects/Keywords: Endocrinology; Testosterone

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Vrolyk, M. (2015). Testosterone replacement therapy. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/16024

Chicago Manual of Style (16^th Edition):

Vrolyk, Michael. “Testosterone replacement therapy.” 2015. Masters Thesis, Boston University. Accessed January 18, 2021. http://hdl.handle.net/2144/16024.

MLA Handbook (7^th Edition):

Vrolyk, Michael. “Testosterone replacement therapy.” 2015. Web. 18 Jan 2021.

Vancouver:

Vrolyk M. Testosterone replacement therapy. [Internet] [Masters thesis]. Boston University; 2015. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/2144/16024.

Council of Science Editors:

Vrolyk M. Testosterone replacement therapy. [Masters Thesis]. Boston University; 2015. Available from: http://hdl.handle.net/2144/16024

10. Laczko, Stephen M. Evaluation of the Thyroid Endocrine System in Two Flatfish Species in Relation to Exposures to Legacy Contaminants and Contaminants of Emerging Concern.

Degree: 2018, California State University, Long Beach

URL: http://pqdtopen.proquest.com/#viewpdf?dispub=10826608

► Anthropogenic contaminants have been well documented in Southern California coastal marine waters and are largely associated with point source pollution entities like waste water… (more)

Subjects/Keywords: Biology; Endocrinology

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APA (6^th Edition):

Laczko, S. M. (2018). Evaluation of the Thyroid Endocrine System in Two Flatfish Species in Relation to Exposures to Legacy Contaminants and Contaminants of Emerging Concern. (Thesis). California State University, Long Beach. Retrieved from http://pqdtopen.proquest.com/#viewpdf?dispub=10826608

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Laczko, Stephen M. “Evaluation of the Thyroid Endocrine System in Two Flatfish Species in Relation to Exposures to Legacy Contaminants and Contaminants of Emerging Concern.” 2018. Thesis, California State University, Long Beach. Accessed January 18, 2021. http://pqdtopen.proquest.com/#viewpdf?dispub=10826608.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Laczko, Stephen M. “Evaluation of the Thyroid Endocrine System in Two Flatfish Species in Relation to Exposures to Legacy Contaminants and Contaminants of Emerging Concern.” 2018. Web. 18 Jan 2021.

Vancouver:

Laczko SM. Evaluation of the Thyroid Endocrine System in Two Flatfish Species in Relation to Exposures to Legacy Contaminants and Contaminants of Emerging Concern. [Internet] [Thesis]. California State University, Long Beach; 2018. [cited 2021 Jan 18]. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=10826608.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Laczko SM. Evaluation of the Thyroid Endocrine System in Two Flatfish Species in Relation to Exposures to Legacy Contaminants and Contaminants of Emerging Concern. [Thesis]. California State University, Long Beach; 2018. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=10826608

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

College of William and Mary

11. Hirsh, Larry Stephen. Serum Concentrations of Follicle Stimulating Hormone and Luteinizing Hormone in Laboratory Populations of the Prairie Deermouse (Peromyscus maniculatus Bairdii).

Degree: MA, Biology, 1975, College of William and Mary

URL: https://scholarworks.wm.edu/etd/1539624891

Subjects/Keywords: Endocrinology

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APA (6^th Edition):

Hirsh, L. S. (1975). Serum Concentrations of Follicle Stimulating Hormone and Luteinizing Hormone in Laboratory Populations of the Prairie Deermouse (Peromyscus maniculatus Bairdii). (Masters Thesis). College of William and Mary. Retrieved from https://scholarworks.wm.edu/etd/1539624891

Chicago Manual of Style (16^th Edition):

Hirsh, Larry Stephen. “Serum Concentrations of Follicle Stimulating Hormone and Luteinizing Hormone in Laboratory Populations of the Prairie Deermouse (Peromyscus maniculatus Bairdii).” 1975. Masters Thesis, College of William and Mary. Accessed January 18, 2021. https://scholarworks.wm.edu/etd/1539624891.

MLA Handbook (7^th Edition):

Hirsh, Larry Stephen. “Serum Concentrations of Follicle Stimulating Hormone and Luteinizing Hormone in Laboratory Populations of the Prairie Deermouse (Peromyscus maniculatus Bairdii).” 1975. Web. 18 Jan 2021.

Vancouver:

Hirsh LS. Serum Concentrations of Follicle Stimulating Hormone and Luteinizing Hormone in Laboratory Populations of the Prairie Deermouse (Peromyscus maniculatus Bairdii). [Internet] [Masters thesis]. College of William and Mary; 1975. [cited 2021 Jan 18]. Available from: https://scholarworks.wm.edu/etd/1539624891.

Council of Science Editors:

Hirsh LS. Serum Concentrations of Follicle Stimulating Hormone and Luteinizing Hormone in Laboratory Populations of the Prairie Deermouse (Peromyscus maniculatus Bairdii). [Masters Thesis]. College of William and Mary; 1975. Available from: https://scholarworks.wm.edu/etd/1539624891

College of William and Mary

12. Bayne, Cary Gresham. An Investigation of the Role of Hormones and the Hypothalamus in Ovarian Growth and Vitellogenesis in Sceloporus cyanogenys.

Degree: MA, Biology, 1970, College of William and Mary

URL: https://scholarworks.wm.edu/etd/1539624687

Subjects/Keywords: Endocrinology

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APA (6^th Edition):

Bayne, C. G. (1970). An Investigation of the Role of Hormones and the Hypothalamus in Ovarian Growth and Vitellogenesis in Sceloporus cyanogenys. (Masters Thesis). College of William and Mary. Retrieved from https://scholarworks.wm.edu/etd/1539624687

Chicago Manual of Style (16^th Edition):

Bayne, Cary Gresham. “An Investigation of the Role of Hormones and the Hypothalamus in Ovarian Growth and Vitellogenesis in Sceloporus cyanogenys.” 1970. Masters Thesis, College of William and Mary. Accessed January 18, 2021. https://scholarworks.wm.edu/etd/1539624687.

MLA Handbook (7^th Edition):

Bayne, Cary Gresham. “An Investigation of the Role of Hormones and the Hypothalamus in Ovarian Growth and Vitellogenesis in Sceloporus cyanogenys.” 1970. Web. 18 Jan 2021.

Vancouver:

Bayne CG. An Investigation of the Role of Hormones and the Hypothalamus in Ovarian Growth and Vitellogenesis in Sceloporus cyanogenys. [Internet] [Masters thesis]. College of William and Mary; 1970. [cited 2021 Jan 18]. Available from: https://scholarworks.wm.edu/etd/1539624687.

Council of Science Editors:

Bayne CG. An Investigation of the Role of Hormones and the Hypothalamus in Ovarian Growth and Vitellogenesis in Sceloporus cyanogenys. [Masters Thesis]. College of William and Mary; 1970. Available from: https://scholarworks.wm.edu/etd/1539624687

College of William and Mary

13. Nicoll, James B. TR Phosphorylation & Nuclear Import.

Degree: MA, Biology, 2001, College of William and Mary

URL: https://scholarworks.wm.edu/etd/1539626303

Subjects/Keywords: Endocrinology

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APA (6^th Edition):

Nicoll, J. B. (2001). TR Phosphorylation & Nuclear Import. (Masters Thesis). College of William and Mary. Retrieved from https://scholarworks.wm.edu/etd/1539626303

Chicago Manual of Style (16^th Edition):

Nicoll, James B. “TR Phosphorylation & Nuclear Import.” 2001. Masters Thesis, College of William and Mary. Accessed January 18, 2021. https://scholarworks.wm.edu/etd/1539626303.

MLA Handbook (7^th Edition):

Nicoll, James B. “TR Phosphorylation & Nuclear Import.” 2001. Web. 18 Jan 2021.

Vancouver:

Nicoll JB. TR Phosphorylation & Nuclear Import. [Internet] [Masters thesis]. College of William and Mary; 2001. [cited 2021 Jan 18]. Available from: https://scholarworks.wm.edu/etd/1539626303.

Council of Science Editors:

Nicoll JB. TR Phosphorylation & Nuclear Import. [Masters Thesis]. College of William and Mary; 2001. Available from: https://scholarworks.wm.edu/etd/1539626303

College of William and Mary

14. Grespin, Matthew Edward. Nuclear Export of the Thyroid Hormone Receptor [Alpha].

Degree: MS, Biology, 2008, College of William and Mary

URL: https://scholarworks.wm.edu/etd/1539626868

Subjects/Keywords: Endocrinology

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APA (6^th Edition):

Grespin, M. E. (2008). Nuclear Export of the Thyroid Hormone Receptor [Alpha]. (Masters Thesis). College of William and Mary. Retrieved from https://scholarworks.wm.edu/etd/1539626868

Chicago Manual of Style (16^th Edition):

Grespin, Matthew Edward. “Nuclear Export of the Thyroid Hormone Receptor [Alpha].” 2008. Masters Thesis, College of William and Mary. Accessed January 18, 2021. https://scholarworks.wm.edu/etd/1539626868.

MLA Handbook (7^th Edition):

Grespin, Matthew Edward. “Nuclear Export of the Thyroid Hormone Receptor [Alpha].” 2008. Web. 18 Jan 2021.

Vancouver:

Grespin ME. Nuclear Export of the Thyroid Hormone Receptor [Alpha]. [Internet] [Masters thesis]. College of William and Mary; 2008. [cited 2021 Jan 18]. Available from: https://scholarworks.wm.edu/etd/1539626868.

Council of Science Editors:

Grespin ME. Nuclear Export of the Thyroid Hormone Receptor [Alpha]. [Masters Thesis]. College of William and Mary; 2008. Available from: https://scholarworks.wm.edu/etd/1539626868

College of William and Mary

15. Subramanian, Kelly Sue. Nuclear Export Dynamics of Thyroid Hormone Receptors.

Degree: MS, Biology, 2012, College of William and Mary

URL: https://scholarworks.wm.edu/etd/1539626924

Subjects/Keywords: Endocrinology

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APA (6^th Edition):

Subramanian, K. S. (2012). Nuclear Export Dynamics of Thyroid Hormone Receptors. (Masters Thesis). College of William and Mary. Retrieved from https://scholarworks.wm.edu/etd/1539626924

Chicago Manual of Style (16^th Edition):

Subramanian, Kelly Sue. “Nuclear Export Dynamics of Thyroid Hormone Receptors.” 2012. Masters Thesis, College of William and Mary. Accessed January 18, 2021. https://scholarworks.wm.edu/etd/1539626924.

MLA Handbook (7^th Edition):

Subramanian, Kelly Sue. “Nuclear Export Dynamics of Thyroid Hormone Receptors.” 2012. Web. 18 Jan 2021.

Vancouver:

Subramanian KS. Nuclear Export Dynamics of Thyroid Hormone Receptors. [Internet] [Masters thesis]. College of William and Mary; 2012. [cited 2021 Jan 18]. Available from: https://scholarworks.wm.edu/etd/1539626924.

Council of Science Editors:

Subramanian KS. Nuclear Export Dynamics of Thyroid Hormone Receptors. [Masters Thesis]. College of William and Mary; 2012. Available from: https://scholarworks.wm.edu/etd/1539626924

Oregon State University

16. Chambers, Derrell Lynn. The endocrine control of the early stages of oöcyte maturation in Leucophaea maderae (FAB.).

Degree: PhD, Entomology, 1965, Oregon State University

URL: http://hdl.handle.net/1957/48010

► A procedure was developed for the isolation and maintenance of isolated abdomina of the cockroach, Leucophaea maderae. The degree of injury and loss of body… (more)

▼ A procedure was developed for the isolation and maintenance of isolated abdomina of the cockroach, Leucophaea maderae. The degree of injury and loss of body fluid was best minimized by ligating the animals immediately following the final molt. The nutritional needs of the isolates were satisfied by filling the animals' crops with a glucose or casamino acid-glucose solution prior to separation of the abdomina. Isolates prepared in this manner quickly recovered from the operation and remained quiescent with normal heart beat and cercal response for periods extending to several months. It was necessary to provide the isolates with an amino acid solution for maximum responsiveness of the reproductive organs to implanted corpora allata. Response was evaluated on the basis of accessory gland activation and oocyte growth. The nymphal diet did not contribute to the responsiveness of the accessory glands or oocytes. Nymphs fed only sucrose prior to the final molt did not provide abdomina responsive to corpora allata unless the newly molted adults were force-fed with amino acids prior to isolation. The amino acid requirement could also be satisfied by injection of the isolates. Abdomina isolated from nymphs fed dog food and force-fed either saline solution or whole casein were not responsive. A time course study of the responsiveness of the oocytes to corpora allata implants showed that the capacity for response coincided with the normal mating time of intact females. Oocytes were unresponsive before the sixth day following ecdysis and thereafter reacted fairly uniformly. Inactive corpora allata obtained from pregnant females returned to activity when implanted in allatectomized intact females. However, such glands produced no response in the reproductive organs of isolated abdomina within the same period of time. It was concluded that reactivation of the corpora allata was due to humoral stimulus present in intact females but absent in the isolates, rather than to an intrinsic cyclic activity as other workers had suggested. Bioassays of materials with known gonadotropic activity were attempted. Farnesol was tested as an external smear on the cuticle of isolated abdomina, and a juvenile hormone extract was tested by injection. Neither of these materials initiated the growth of oocytes, and the maximum accessory gland response observed was very slight. Examination of the evolution of radioactive CO₂ following the injection of isotopically labelled glucose and acetate indicated that the respiratory activity of isolates was reproducible and that abdomina continued to function uniformly for several weeks following isolation. The incorporation of acetate-C¹⁴ into lipids was more variable than its oxidation, but possibly not more so than would be expected with intact animals. The levels of incorporation were similar to those which have been reported for intact roaches. No correlation was observed between the action of the corpora allata on the reproductive organs and the oxidation or… Advisors/Committee Members: Brooks, Victor Jack (advisor).

Subjects/Keywords: Endocrinology

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APA (6^th Edition):

Chambers, D. L. (1965). The endocrine control of the early stages of oöcyte maturation in Leucophaea maderae (FAB.). (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/48010

Chicago Manual of Style (16^th Edition):

Chambers, Derrell Lynn. “The endocrine control of the early stages of oöcyte maturation in Leucophaea maderae (FAB.).” 1965. Doctoral Dissertation, Oregon State University. Accessed January 18, 2021. http://hdl.handle.net/1957/48010.

MLA Handbook (7^th Edition):

Chambers, Derrell Lynn. “The endocrine control of the early stages of oöcyte maturation in Leucophaea maderae (FAB.).” 1965. Web. 18 Jan 2021.

Vancouver:

Chambers DL. The endocrine control of the early stages of oöcyte maturation in Leucophaea maderae (FAB.). [Internet] [Doctoral dissertation]. Oregon State University; 1965. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/1957/48010.

Council of Science Editors:

Chambers DL. The endocrine control of the early stages of oöcyte maturation in Leucophaea maderae (FAB.). [Doctoral Dissertation]. Oregon State University; 1965. Available from: http://hdl.handle.net/1957/48010

Florida State University

17. Stathopoulos, Andrea Mahi. Hypothalamic Factors Involved in the Regulation of Prolactin Surges in Female Rats.

Degree: PhD, Biological Science, 2015, Florida State University

URL: http://purl.flvc.org/fsu/fd/FSU_migr_etd-9688 ;

► Prolactin is a fertility hormone produced and released by the anterior pituitary gland. Normal changes in prolactin levels influence fertility and these changes are carefully… (more)

▼ Prolactin is a fertility hormone produced and released by the anterior pituitary gland. Normal changes in prolactin levels influence fertility and these changes are carefully regulated by neuroendocrine cells in the hypothalamus. Specifically, prolactin surges along with luteinizing hormone to stimulate ovulation and mating behaviors in rodents. Prolactin also follows a twice-daily surge pattern during rodent pregnancy, helping to maintain the pregnancy and prepare the maternal brain for offspring care. Dopamine is the primary regulatory of prolactin and acts through tonic inhibition during non-surge times. High levels of prolactin feedback to stimulate dopamine and thereby reduce prolactin back down to normal, low levels. However, dopamine is not alone in regulating prolactin release. Early mathematical models from the lab helped to identify some shortcomings in the understanding of prolactin regulation. Based on the existing literature, a model was designed to replicate experimental results. When I came to lab and began reviewing this literature and the model's assumptions, I began to ask some important questions: Do dopamine levels change dramatically with the prolactin surges? Does the timing signal in the model really act as an inhibitory signal? Does the stimulatory signal act alone to drive surges of prolactin release? What else is out that that feeds into this circuit? These perfectly timed surges of prolactin must somehow be controlled by the brain's central clock. One clock signal, VIP, has been implicated in indirect prolactin regulation. This neurotransmitter could stimulate prolactin either by inhibiting dopamine or by activating a prolactin simulator. In this dissertation, I show that it may in fact be doing both. Oxytocin is one potential, and particularly potent, prolactin stimulator that is itself implicated in reproduction and the associated social behaviors. Released at the posterior pituitary, I hypothesized that plasma oxytocin levels might be predictive of the large prolactin surges observed during times of fertility and pregnancy. However, the data fail to support such a clear direct correlation. Other hypothalamic factors that have also been proposed to be involved in prolactin regulation include the endogenous opioid dynorphin. One major hypothalamic source of dynorphin are the KNDy neurons that co-secrete kisspeptin, neurokinin B, and dynorphin. All these neurotransmitters have been studied for their roles in luteinizing hormone regulation. Research presented here shows that the KNDy neuron dynorphin, while directly involved in luteinizing hormone surge release, is not involved in prolactin surge release. In fact, another KNDy product is likely involved in the single, estrogen-induced fertility surge, while another, still unknown, source of dynorphin is involved during the twice-daily prolactin surge pattern. Overall, this dissertation explores many aspects beyond just dopamine as possible regulatory inputs to the prolactin control circuit. Our simplified rodent models and the mathematical… Advisors/Committee Members: R. (Richard) Bertram (professor co-directing dissertation), Paul Q. Trombley (professor co-directing dissertation), Timothy M. Logan (university representative), Kimberly A. Hughes (committee member), Arturo Eduardo Gonzalez-Iglesias (committee member).

Subjects/Keywords: Neurosciences; Endocrinology

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APA (6^th Edition):

Stathopoulos, A. M. (2015). Hypothalamic Factors Involved in the Regulation of Prolactin Surges in Female Rats. (Doctoral Dissertation). Florida State University. Retrieved from http://purl.flvc.org/fsu/fd/FSU_migr_etd-9688 ;

Chicago Manual of Style (16^th Edition):

Stathopoulos, Andrea Mahi. “Hypothalamic Factors Involved in the Regulation of Prolactin Surges in Female Rats.” 2015. Doctoral Dissertation, Florida State University. Accessed January 18, 2021. http://purl.flvc.org/fsu/fd/FSU_migr_etd-9688 ;.

MLA Handbook (7^th Edition):

Stathopoulos, Andrea Mahi. “Hypothalamic Factors Involved in the Regulation of Prolactin Surges in Female Rats.” 2015. Web. 18 Jan 2021.

Vancouver:

Stathopoulos AM. Hypothalamic Factors Involved in the Regulation of Prolactin Surges in Female Rats. [Internet] [Doctoral dissertation]. Florida State University; 2015. [cited 2021 Jan 18]. Available from: http://purl.flvc.org/fsu/fd/FSU_migr_etd-9688 ;.

Council of Science Editors:

Stathopoulos AM. Hypothalamic Factors Involved in the Regulation of Prolactin Surges in Female Rats. [Doctoral Dissertation]. Florida State University; 2015. Available from: http://purl.flvc.org/fsu/fd/FSU_migr_etd-9688 ;

California State University – East Bay

18. Vieira, Roland. The Endocrine Axis Controlling the Osmoregulating Gills of Pachygrapsus crassipes.

Degree: 1988, California State University – East Bay

URL: http://hdl.handle.net/10211.3/7583

► The euryhaline rock crab Pachygrapsus crassipes is exposed to varying salinities depending on the weather, the tides, and the seasons, and must therefore make physiological… (more)

Subjects/Keywords: Endocrinology

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APA (6^th Edition):

Vieira, R. (1988). The Endocrine Axis Controlling the Osmoregulating Gills of Pachygrapsus crassipes. (Thesis). California State University – East Bay. Retrieved from http://hdl.handle.net/10211.3/7583

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Vieira, Roland. “The Endocrine Axis Controlling the Osmoregulating Gills of Pachygrapsus crassipes.” 1988. Thesis, California State University – East Bay. Accessed January 18, 2021. http://hdl.handle.net/10211.3/7583.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Vieira, Roland. “The Endocrine Axis Controlling the Osmoregulating Gills of Pachygrapsus crassipes.” 1988. Web. 18 Jan 2021.

Vancouver:

Vieira R. The Endocrine Axis Controlling the Osmoregulating Gills of Pachygrapsus crassipes. [Internet] [Thesis]. California State University – East Bay; 1988. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10211.3/7583.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Vieira R. The Endocrine Axis Controlling the Osmoregulating Gills of Pachygrapsus crassipes. [Thesis]. California State University – East Bay; 1988. Available from: http://hdl.handle.net/10211.3/7583

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Minnesota

19. Sandiford, Irene. The Basal Metabolic Rate in Exophthalmic Goitre (1917 Cases) With A Brief Description of the Technic Used at the Mayo Clinic; The Effect of the Subcutaneous Injection of Adrenalin Chlorid on the Heat Production, Blood Pressure and Pulse Rate in Man.

Degree: PhD, Endocrinology, 1919, University of Minnesota

URL: http://hdl.handle.net/11299/178070

Subjects/Keywords: Endocrinology

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APA (6^th Edition):

Sandiford, I. (1919). The Basal Metabolic Rate in Exophthalmic Goitre (1917 Cases) With A Brief Description of the Technic Used at the Mayo Clinic; The Effect of the Subcutaneous Injection of Adrenalin Chlorid on the Heat Production, Blood Pressure and Pulse Rate in Man. (Doctoral Dissertation). University of Minnesota. Retrieved from http://hdl.handle.net/11299/178070

Chicago Manual of Style (16^th Edition):

Sandiford, Irene. “The Basal Metabolic Rate in Exophthalmic Goitre (1917 Cases) With A Brief Description of the Technic Used at the Mayo Clinic; The Effect of the Subcutaneous Injection of Adrenalin Chlorid on the Heat Production, Blood Pressure and Pulse Rate in Man.” 1919. Doctoral Dissertation, University of Minnesota. Accessed January 18, 2021. http://hdl.handle.net/11299/178070.

MLA Handbook (7^th Edition):

Sandiford, Irene. “The Basal Metabolic Rate in Exophthalmic Goitre (1917 Cases) With A Brief Description of the Technic Used at the Mayo Clinic; The Effect of the Subcutaneous Injection of Adrenalin Chlorid on the Heat Production, Blood Pressure and Pulse Rate in Man.” 1919. Web. 18 Jan 2021.

Vancouver:

Sandiford I. The Basal Metabolic Rate in Exophthalmic Goitre (1917 Cases) With A Brief Description of the Technic Used at the Mayo Clinic; The Effect of the Subcutaneous Injection of Adrenalin Chlorid on the Heat Production, Blood Pressure and Pulse Rate in Man. [Internet] [Doctoral dissertation]. University of Minnesota; 1919. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/11299/178070.

Council of Science Editors:

Sandiford I. The Basal Metabolic Rate in Exophthalmic Goitre (1917 Cases) With A Brief Description of the Technic Used at the Mayo Clinic; The Effect of the Subcutaneous Injection of Adrenalin Chlorid on the Heat Production, Blood Pressure and Pulse Rate in Man. [Doctoral Dissertation]. University of Minnesota; 1919. Available from: http://hdl.handle.net/11299/178070

McGill University

20. Courtright, Mary N. Investigation of a method of fractionation of anterior pituitary.

Degree: PhD, Department of Endocrinology, 1944, McGill University

URL: https://escholarship.mcgill.ca/downloads/th83m256g.pdf ; https://escholarship.mcgill.ca/concern/theses/sq87bx477

► Our knowledge of the hypophysis cerebri orpituitary gland dates back to the early anatomists.Cilen, who considered that the gland acted as a filterfor the mucous… (more)

Subjects/Keywords: Endocrinology.

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APA (6^th Edition):

Courtright, M. N. (1944). Investigation of a method of fractionation of anterior pituitary. (Doctoral Dissertation). McGill University. Retrieved from https://escholarship.mcgill.ca/downloads/th83m256g.pdf ; https://escholarship.mcgill.ca/concern/theses/sq87bx477

Chicago Manual of Style (16^th Edition):

Courtright, Mary N. “Investigation of a method of fractionation of anterior pituitary.” 1944. Doctoral Dissertation, McGill University. Accessed January 18, 2021. https://escholarship.mcgill.ca/downloads/th83m256g.pdf ; https://escholarship.mcgill.ca/concern/theses/sq87bx477.

MLA Handbook (7^th Edition):

Courtright, Mary N. “Investigation of a method of fractionation of anterior pituitary.” 1944. Web. 18 Jan 2021.

Vancouver:

Courtright MN. Investigation of a method of fractionation of anterior pituitary. [Internet] [Doctoral dissertation]. McGill University; 1944. [cited 2021 Jan 18]. Available from: https://escholarship.mcgill.ca/downloads/th83m256g.pdf ; https://escholarship.mcgill.ca/concern/theses/sq87bx477.

Council of Science Editors:

Courtright MN. Investigation of a method of fractionation of anterior pituitary. [Doctoral Dissertation]. McGill University; 1944. Available from: https://escholarship.mcgill.ca/downloads/th83m256g.pdf ; https://escholarship.mcgill.ca/concern/theses/sq87bx477

University of Maryland

21. McNamara, Bernard Patrick. The biological assay of estrogenic hormones.

Degree: 1942, University of Maryland

URL: http://hdl.handle.net/1903/17486

Subjects/Keywords: Endocrinology

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

McNamara, B. P. (1942). The biological assay of estrogenic hormones. (Thesis). University of Maryland. Retrieved from http://hdl.handle.net/1903/17486

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

McNamara, Bernard Patrick. “The biological assay of estrogenic hormones.” 1942. Thesis, University of Maryland. Accessed January 18, 2021. http://hdl.handle.net/1903/17486.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

McNamara, Bernard Patrick. “The biological assay of estrogenic hormones.” 1942. Web. 18 Jan 2021.

Vancouver:

McNamara BP. The biological assay of estrogenic hormones. [Internet] [Thesis]. University of Maryland; 1942. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/1903/17486.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

McNamara BP. The biological assay of estrogenic hormones. [Thesis]. University of Maryland; 1942. Available from: http://hdl.handle.net/1903/17486

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Maryland

22. Conner, Mark Hale. Effects of thyroxine sex hormones, and stress on hormonal interactions as measured by gland and organ weights, metabolic rate, resistance to exhaustion, and adrenal histology of New Hampshire.

Degree: 1953, University of Maryland

URL: http://hdl.handle.net/1903/17619

Subjects/Keywords: Endocrinology

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APA (6^th Edition):

Conner, M. H. (1953). Effects of thyroxine sex hormones, and stress on hormonal interactions as measured by gland and organ weights, metabolic rate, resistance to exhaustion, and adrenal histology of New Hampshire. (Thesis). University of Maryland. Retrieved from http://hdl.handle.net/1903/17619

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Conner, Mark Hale. “Effects of thyroxine sex hormones, and stress on hormonal interactions as measured by gland and organ weights, metabolic rate, resistance to exhaustion, and adrenal histology of New Hampshire.” 1953. Thesis, University of Maryland. Accessed January 18, 2021. http://hdl.handle.net/1903/17619.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Conner, Mark Hale. “Effects of thyroxine sex hormones, and stress on hormonal interactions as measured by gland and organ weights, metabolic rate, resistance to exhaustion, and adrenal histology of New Hampshire.” 1953. Web. 18 Jan 2021.

Vancouver:

Conner MH. Effects of thyroxine sex hormones, and stress on hormonal interactions as measured by gland and organ weights, metabolic rate, resistance to exhaustion, and adrenal histology of New Hampshire. [Internet] [Thesis]. University of Maryland; 1953. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/1903/17619.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Conner MH. Effects of thyroxine sex hormones, and stress on hormonal interactions as measured by gland and organ weights, metabolic rate, resistance to exhaustion, and adrenal histology of New Hampshire. [Thesis]. University of Maryland; 1953. Available from: http://hdl.handle.net/1903/17619

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

The Ohio State University

23. Walton, James C. Photoperiod, Brain Plasticity, and Behavior.

Degree: PhD, Neuroscience Graduate Studies Program, 2013, The Ohio State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1364994837

► Outside of the tropics, distinctive sets of adaptations have evolved to cope with the unique demands of winter and summer on survival and reproduction. Because… (more)

▼ Outside of the tropics, distinctive sets of adaptations have evolved to cope with the unique demands of winter and summer on survival and reproduction. Because these seasonal adaptations often require significant time to develop, individuals rely upon an environmental signal (day length) to alter gene expression in order to produce the suite of season-specific adaptations. Photoperiodism is the ability of plants and animals to measure environmental day length (photoperiod) to ascertain the time of year and engage in seasonally appropriate adaptations; the annual cycle of changing photoperiod provides the environmental switch between seasonal phenotypes. The aim of this dissertation is to describe the influence of photoperiod on phenotype, the distribution of energetically expensive processes across the year, to maximize survival and fitness in males of a small photoperiodic rodent species, white-footed mice (Peromyscus leucopus).In Chapter 1 I provide a review of photoperiodism and an overview of the suite of adaptive responses at multiple levels to changing day lengths in a variety of vertebrate species. Among the adaptive responses in male white-footed mice are reduced brain size, and a marked reduction in hippocampal volume. Given that the hippocampus is critical for spatial learning and memory, I explore the functional outcomes of having a small hippocampus in Chapter 2 utilizing a spatial learning and memory task. I also assess neuronal physiology in the form of long-term potentiation in the hippocampus, the form of neuronal plasticity that is the putative mechanism of how memories are stored in the brain. In Chapters 3 and 4 I explore how photoperiod-mediated changes in hormones alter hippocampal function. Given that mammals use pineal melatonin rhythms to monitor day length, in Chapter 3 I explore the role of melatonin in the functional and structural hippocampal changes described in Chapter 2. Downstream of pineal melatonin signaling, gonadal steroids are also altered in short days in this species, and the role of gonadal steroids in photoperiod-mediated changes in the hippocampus is explored in Chapter 4. Given that the hippocampus is heavily interconnected with other brain structures, it follows that these areas, and behaviors dependent upon them, are altered in short days as well. In Chapter 5 I explore how photoperiod affects the structure and function of the amygdala and alters amygdala-dependent fear behaviors.Whereas Chapters 3-5 explore functional outcomes of reduced brain volume, in Chapter 6 and 7 I explore a potential mechanism by which brain mass and hippocampal volume may be altered. The recruitment and retention of new neurons in the brains of adults may contribute to volumetric and mass changes; thus, I explore the effect of photoperiod on neurogenesis in the two main neurogenic niches of adult brains: the olfactory bulb (Chapter 6) and the dentate gyrus of the hippocampus (Chapter 7). In conclusion, in Chapter 8 I summarize my findings and propose future directions for research in this species… Advisors/Committee Members: Nelson, Randy (Advisor).

Subjects/Keywords: Neurosciences; Endocrinology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Walton, J. C. (2013). Photoperiod, Brain Plasticity, and Behavior. (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1364994837

Chicago Manual of Style (16^th Edition):

Walton, James C. “Photoperiod, Brain Plasticity, and Behavior.” 2013. Doctoral Dissertation, The Ohio State University. Accessed January 18, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu1364994837.

MLA Handbook (7^th Edition):

Walton, James C. “Photoperiod, Brain Plasticity, and Behavior.” 2013. Web. 18 Jan 2021.

Vancouver:

Walton JC. Photoperiod, Brain Plasticity, and Behavior. [Internet] [Doctoral dissertation]. The Ohio State University; 2013. [cited 2021 Jan 18]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1364994837.

Council of Science Editors:

Walton JC. Photoperiod, Brain Plasticity, and Behavior. [Doctoral Dissertation]. The Ohio State University; 2013. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1364994837

24. Kluger, Nicolas. New insights in Autoimmune Polyendocrine Syndromes 1 and 2.

Degree: Institute of Clinical Medicine, Department of Dermatology, Venereology and Allergology, 2015, University of Helsinki

URL: http://hdl.handle.net/10138/153326

► Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED, OMIM 240300) is a rare autosomal recessive disorder caused by mutations in the autoimmune regulator (AIRE) gene located on chromosome 21… (more)

▼ Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED, OMIM 240300) is a rare autosomal recessive disorder caused by mutations in the autoimmune regulator (AIRE) gene located on chromosome 21 (21q22.3). AIRE deficiency causes a loss in central immune tolerance, leading to the failure to eliminate autoreactive T cells in the thymus and allowing their escape to the periphery. Because of a founder effect, APECED is particularly prevalent in Finland (1/25,000) but is observed worldwide with variable prevalence. APECED patients are susceptible to mucocutaneous candidiasis and multiple endocrine autoimmune diseases such as primary hypoparathyroidism, adrenal insufficiency, primary hypogonadism, type 1 diabetes, hypothyroidism, and hypophysitis. They may also develop additional nonendocrine autoimmune diseases, such as alopecia areata/totalis, vitiligo, gastro-intestinal (GI) diseases, keratitis or tubulointerstitial nephritis (TIN). In addition, the patients typically develop a variety of serum tissue-specific autoantibodies, which are predictive of the development of autoimmune disease and anticytokine antibodies such as those against type I interferons and Th17-related interleukin IL-17 and IL-22. The aim of this thesis was to study such manifestations of APECED that have not been well characterized before and also, to study health-related quality of life among Finnish APECED and Addison s disease/APS2 patients. We evaluated the clinical GI features and searched for novel markers of GI dysfunction in a Finnish cohort of 31 APECED patients. The main upper GI symptoms were dysphagia and retrosternal pain (45%) and the lower GI symptoms were constipation (48%), diarrhoea (45%) and malabsorption (16%). Previously, L-amino-acid decarboxylase (AADC) and tryptophan hydroxylase type 1 (TPH-1) antibodies have been demonstrated in APECED. AADC antibodies were found in 51% and TPH-1 antibodies in 39% of all patients. Also, a T cell response to AADC was detected in 43%. One third of the patients had autoimmune enteropathy (AIE)-related 75 kDa antigen (AIE-75, 33%) and villin (29%) autoantibodies, and antibodies against brush borders and Paneth cells (PCs) were detected in 29% and 20%, respectively. Mucosal intestinal IL-17 expression was decreased or negative in 77% of the intestinal samples. Duodenal chromogranin A and serotonin expression was absent or decreased in 50% and 66% of the patients, respectively. Of the clinical symptoms, constipation correlated with negative serotonin staining (p less than 0.05) and with AADC antibodies (p = 0.019). Importantly, we found a correlation between autoantibodies against AADC, which are critical for serotonin and DOPA synthesis, and constipation. Constipation was also associated with a lack of serotonin expression in the enteroendocrine cells (EECs). Paneth cells (PCs) were lacking in the duodenum in 20% of our intestinal samples, even though this was not associated with GI symptoms. In this Finnish APECED patient cohort, 17% (5/30) had moderate-to-severe renal failure,…

Subjects/Keywords: endocrinology; endocrinology

10 more images…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kluger, N. (2015). New insights in Autoimmune Polyendocrine Syndromes 1 and 2. (Doctoral Dissertation). University of Helsinki. Retrieved from http://hdl.handle.net/10138/153326

Chicago Manual of Style (16^th Edition):

Kluger, Nicolas. “New insights in Autoimmune Polyendocrine Syndromes 1 and 2.” 2015. Doctoral Dissertation, University of Helsinki. Accessed January 18, 2021. http://hdl.handle.net/10138/153326.

MLA Handbook (7^th Edition):

Kluger, Nicolas. “New insights in Autoimmune Polyendocrine Syndromes 1 and 2.” 2015. Web. 18 Jan 2021.

Vancouver:

Kluger N. New insights in Autoimmune Polyendocrine Syndromes 1 and 2. [Internet] [Doctoral dissertation]. University of Helsinki; 2015. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10138/153326.

Council of Science Editors:

Kluger N. New insights in Autoimmune Polyendocrine Syndromes 1 and 2. [Doctoral Dissertation]. University of Helsinki; 2015. Available from: http://hdl.handle.net/10138/153326

Boise State University

25. Wonder, Erin Leigh. A Test of Whether Human Handling Causes Developmental or Habituation Effects on the Hypothalamic-Pituitary-Adrenal Stress Response of Young American Kestrels (Falco Sparverius).

Degree: 2013, Boise State University

URL: https://scholarworks.boisestate.edu/td/759

► Early exposure to stressors affects subsequent stress responses in both mammalian and avian species, with the likelihood for lasting effects depending, in part, on the… (more)

▼ Early exposure to stressors affects subsequent stress responses in both mammalian and avian species, with the likelihood for lasting effects depending, in part, on the magnitude of the stressor. However, it is unclear whether lasting effects are the result of developmental changes to the hypothalamic-pituitary-adrenal (HPA) axis or habituation to the stressor. I investigated the effects of human handling, a known stressor, in free-living American kestrel (Falco sparverius) nestlings to determine if this brief, non-invasive stressor causes lasting changes in the stress response of handled birds, and whether alterations in the stress response were the result of developmental changes (early-handled birds) or habituation (later-handled birds). Broods were randomly assigned to one of three treatment groups: 1) early-handled nestlings were held daily for 15 min for 7 days following hatching, 2) late-handled nestlings were held for the same time and duration beginning on the 18th day post-hatching, and 3) control birds were not handled before sampling for circulating corticosterone (CORT). When nestlings were 25 or 26 days old, they were exposed to either a handling restraint protocol (similar to the treatment of handling) or a novel noise stressor. The stress test not applied on the first day was conducted the next day. During the hour-long restraint protocol, I collected five 75 ul samples of blood through venipuncture of the alar vein. HPA response to a novel stressor was measured by sampling CORT immediately after exposing birds to 10 min of 96 dB(A) (±1 dB) white noise. I analyzed serum CORT levels using enzyme-linked immunoabsorbent assays (ELISA). There was no effect of handling treatment on CORT patterns sampled over the 1 hr restraint test (P = 0.092), though a priori contrasts showed a significant difference between CORT levels of late-handled and control birds at 60 min (P = 0.01). Late-handled birds had lower CORT compared to control birds. In addition, there was no significant differences among handling treatments on noise-induced CORT (P = 0.94). Taken together, these results suggest that the HPA axis was unaffected by human handling and that the changes in CORT at 60 min in late-handled birds is likely the result of habituation to human handling rather than to developmental changes. Further, results indicate that mild and brief stress associated with human handling is unlikely to have negative lasting effects on the stress physiology of young birds.

Subjects/Keywords: corticosterone; stress response; developmental endocrinology; habituation; Endocrinology

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APA (6^th Edition):

Wonder, E. L. (2013). A Test of Whether Human Handling Causes Developmental or Habituation Effects on the Hypothalamic-Pituitary-Adrenal Stress Response of Young American Kestrels (Falco Sparverius). (Thesis). Boise State University. Retrieved from https://scholarworks.boisestate.edu/td/759

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wonder, Erin Leigh. “A Test of Whether Human Handling Causes Developmental or Habituation Effects on the Hypothalamic-Pituitary-Adrenal Stress Response of Young American Kestrels (Falco Sparverius).” 2013. Thesis, Boise State University. Accessed January 18, 2021. https://scholarworks.boisestate.edu/td/759.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wonder, Erin Leigh. “A Test of Whether Human Handling Causes Developmental or Habituation Effects on the Hypothalamic-Pituitary-Adrenal Stress Response of Young American Kestrels (Falco Sparverius).” 2013. Web. 18 Jan 2021.

Vancouver:

Wonder EL. A Test of Whether Human Handling Causes Developmental or Habituation Effects on the Hypothalamic-Pituitary-Adrenal Stress Response of Young American Kestrels (Falco Sparverius). [Internet] [Thesis]. Boise State University; 2013. [cited 2021 Jan 18]. Available from: https://scholarworks.boisestate.edu/td/759.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wonder EL. A Test of Whether Human Handling Causes Developmental or Habituation Effects on the Hypothalamic-Pituitary-Adrenal Stress Response of Young American Kestrels (Falco Sparverius). [Thesis]. Boise State University; 2013. Available from: https://scholarworks.boisestate.edu/td/759

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of California – Berkeley

26. Kapadia, Bhumika. Glucocorticoid-mediated Regulation of Tight Junction Organization in Human Endometrial Cancer Cells.

Degree: Endocrinology, 2013, University of California – Berkeley

URL: http://www.escholarship.org/uc/item/44c031j2

► Communication between cells is important to multi-cellular organisms for processes such as cell survival, development, proliferation, differentiation, adhesion, and migration. Junctional complexes that are comprised… (more)

▼ Communication between cells is important to multi-cellular organisms for processes such as cell survival, development, proliferation, differentiation, adhesion, and migration. Junctional complexes that are comprised of intracellular and intercellular protein components govern these cell-cell interactions. The loss of junctional integrity is implicated in the development and progression of cancer. Although intracellular signaling molecules such as phosphatases and kinases and extracellular signaling molecules such as steroids hormones and growth factors have been shown to regulate cellular junctions, the exact mechanism by which these junctional complexes are assembled, disassembled, and maintained is largely unknown. Glucocorticoids have been shown to regulate junctional complexes in a variety of tissue types. However, their effect on the human endometrium, a tissue that is primarily regulated by steroid hormones, has not been evaluated. Using human endometrial cancer cells, the present work details the effects of glucocorticoids on junctional organization and delineates glucocorticoid-mediated signaling cascades that regulate protein complexes within these cellular junctions. We show that treatment of Ishikawa cells, a well-established human endometrial cancer cell line, with dexamethasone (DEX), a synthetic glucocorticoid, results in organization of tight junctional proteins ZO-1 and occludin to the cell periphery. This effect does not involve changes in cell cycle progression and is attenuated upon treatment with RU-486, a glucocorticoid receptor (GR) antagonist. Furthermore, DEX treatment stimulates the interaction between ZO-1 and occludin that occurs before the localization to the cellular membrane. Total protein expression levels of the GR, ZO-1, occludin and other junctional proteins such as E-cadherin and beta-catenin do not change. The DEX-dependent increase in interaction between ZO-1 and occludin and the subsequent localization of the proteins at the cell periphery is a co-dependent process that requires the expression of both ZO-1 and occludin. An evaluation of various kinases known to regulate interactions between ZO-1 and occludin reveals that activation of AMP-activated protein kinase (AMPK), a serine/threonine kinase, is required for the DEX-induced organization of the ZO-1 and occludin to the cell periphery, as siRNA mediated knockdown of AMPK reverses the effect. Inhibition of c-Src, a non-receptor protein tyrosine kinase, increases the localization of ZO-1 and occludin to the cell membrane where as the inhibition of protein kinase C (PKC), a serine/threonine kinase, disrupts the membranous organization of the two proteins. Activation of AMPK and inhibition of c-Src and PCK also results in changes in interaction between ZO-1 and occludin. Gene expression profile of Ishikawa cells reveals that Kruppel-like factor (KLF9), a transcription factor that is associated with a differentiated endometrium, is significantly up-regulated upon treatment with DEX. Clinical data suggests that loss-of-expression of…

Subjects/Keywords: Endocrinology; Molecular biology

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APA (6^th Edition):

Kapadia, B. (2013). Glucocorticoid-mediated Regulation of Tight Junction Organization in Human Endometrial Cancer Cells. (Thesis). University of California – Berkeley. Retrieved from http://www.escholarship.org/uc/item/44c031j2

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kapadia, Bhumika. “Glucocorticoid-mediated Regulation of Tight Junction Organization in Human Endometrial Cancer Cells.” 2013. Thesis, University of California – Berkeley. Accessed January 18, 2021. http://www.escholarship.org/uc/item/44c031j2.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kapadia, Bhumika. “Glucocorticoid-mediated Regulation of Tight Junction Organization in Human Endometrial Cancer Cells.” 2013. Web. 18 Jan 2021.

Vancouver:

Kapadia B. Glucocorticoid-mediated Regulation of Tight Junction Organization in Human Endometrial Cancer Cells. [Internet] [Thesis]. University of California – Berkeley; 2013. [cited 2021 Jan 18]. Available from: http://www.escholarship.org/uc/item/44c031j2.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kapadia B. Glucocorticoid-mediated Regulation of Tight Junction Organization in Human Endometrial Cancer Cells. [Thesis]. University of California – Berkeley; 2013. Available from: http://www.escholarship.org/uc/item/44c031j2

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Boston University

27. O'Toole, Patrick. Evaluating the vitamin D content in sardines and mackerel.

Degree: MS, Medical Sciences, 2015, Boston University

URL: http://hdl.handle.net/2144/16279

► Vitamin D is an important secosteroid hormone that is responsible for calcium and phosphorus homeostasis. Vitamin D deficiency and insufficiency are an ever increasing global… (more)

Subjects/Keywords: Endocrinology; Vitamin D

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APA (6^th Edition):

O'Toole, P. (2015). Evaluating the vitamin D content in sardines and mackerel. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/16279

Chicago Manual of Style (16^th Edition):

O'Toole, Patrick. “Evaluating the vitamin D content in sardines and mackerel.” 2015. Masters Thesis, Boston University. Accessed January 18, 2021. http://hdl.handle.net/2144/16279.

MLA Handbook (7^th Edition):

O'Toole, Patrick. “Evaluating the vitamin D content in sardines and mackerel.” 2015. Web. 18 Jan 2021.

Vancouver:

O'Toole P. Evaluating the vitamin D content in sardines and mackerel. [Internet] [Masters thesis]. Boston University; 2015. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/2144/16279.

Council of Science Editors:

O'Toole P. Evaluating the vitamin D content in sardines and mackerel. [Masters Thesis]. Boston University; 2015. Available from: http://hdl.handle.net/2144/16279

Boston University

28. Allen, Katherine. The effects of troglitazone and PMA on AMPK in HepG2 cells.

Degree: MS, Medical Sciences, 2016, Boston University

URL: http://hdl.handle.net/2144/16783

► Type 2 diabetes, as well as other metabolic diseases, is an increasing global health concern and many of the mechanisms of both the disease and… (more)

▼ Type 2 diabetes, as well as other metabolic diseases, is an increasing global health concern and many of the mechanisms of both the disease and its current drug treatments have not been fully described. It has been shown that the anti-diabetic class of drugs, the thiazolidinediones, work via both a known PPARγ-dependent, and a lesser known PPARγ-independent mechanism of action. This PPARγ-independent mechanism likely involves the metabolic regulatory molecule AMPK, which has a newly elucidated inhibitory site of phosphorylation at Ser485/Ser491. In this study we sought to determine if the thiazolidinedione troglitazone affects AMPK in HepG2 liver cells via phosphorylation at both the known Thr172 site as well as the letter understood Ser485 site. We also looked for potential upstream kinases of the Ser485 site by comparing our results to recently proposed mechanisms of phosphorylation here. HepG2 cells were cultured in the lab and treated with troglitazone to determine time- and dose- dependent effects on AMPK. We also treated cultured HepG2 cells with PMA as well as troglitazone and PMA in order to compare mechanisms of action of troglitazone on AMPK. Results were analyzed using common western blot techniques and statistical analysis. Our data found that troglitazone increased AMPK activity by increasing phosphorylation at Thr172 in a time- and dose- dependent manner. The inhibitory site Ser485 was also increasingly phosphorylated with troglitazone treatments, although the net result of troglitazone treatment remained AMPK activation. The recently elucidated results from our laboratory showing the mechanism of p-AMPK Ser485 phosphorylation via PKD after PMA treatment also occurred in HepG2 cells, although this did not appear to be the mechanism by which troglitazone phosphorylated AMPK at Ser485. These data support the current research that there is an AMPK mediated PPARγ-independent mechanism of troglitazone treatment for type 2 diabetes and other metabolic diseases. The results do however bring into question the full effects of the drug on AMPK at a molecular level and leaves room for new research in this area, specifically the exact mechanism by which troglitazone phosphorylates AMPK at Ser485. Our data also brings up new questions as to the simultaneous phosphorylation of AMPK at both Thr172 and Ser485 and what this means for the activity of the molecule as a whole, a current area of critical research. Lastly our data support the newly elucidated mechanism of AMPK phosphorylation at Ser485 via PKD1, an exciting and novel discovery and potential target for therapeutic intervention.

Subjects/Keywords: Endocrinology; AMPK; Troglitazone

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APA (6^th Edition):

Allen, K. (2016). The effects of troglitazone and PMA on AMPK in HepG2 cells. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/16783

Chicago Manual of Style (16^th Edition):

Allen, Katherine. “The effects of troglitazone and PMA on AMPK in HepG2 cells.” 2016. Masters Thesis, Boston University. Accessed January 18, 2021. http://hdl.handle.net/2144/16783.

MLA Handbook (7^th Edition):

Allen, Katherine. “The effects of troglitazone and PMA on AMPK in HepG2 cells.” 2016. Web. 18 Jan 2021.

Vancouver:

Allen K. The effects of troglitazone and PMA on AMPK in HepG2 cells. [Internet] [Masters thesis]. Boston University; 2016. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/2144/16783.

Council of Science Editors:

Allen K. The effects of troglitazone and PMA on AMPK in HepG2 cells. [Masters Thesis]. Boston University; 2016. Available from: http://hdl.handle.net/2144/16783

West Virginia University

29. Nestor, Casey C. Evidence of a Role for Three Neuropeptides that Mediate Steroid Negative Feedback on Gonadotropin Releasing Hormone/Luteinizing Hormone Secretion in the Ewe: Kisspeptin, Neurokinin B and Orphanin FQ.

Degree: PhD, Microbiology, Immunology, and Cell Biology, 2012, West Virginia University

URL: https://doi.org/10.33915/etd.4903 ; https://researchrepository.wvu.edu/etd/4903

► Gonadotropin-releasing hormone (GnRH) is the final common output from the central nervous system for controlling luteinizing hormone (LH) secretion from the anterior pituitary. GnRH, and… (more)

▼ Gonadotropin-releasing hormone (GnRH) is the final common output from the central nervous system for controlling luteinizing hormone (LH) secretion from the anterior pituitary. GnRH, and subsequently LH, secretion for most of the menstrual/estrous cycle occurs in an episodic pattern that is controlled by the inhibitory actions of estradiol and progesterone. However, GnRH neurons are devoid of the appropriate steroid receptors, therefore, estradiol and progesterone must mediate their effects on GnRH/LH secretion through interneurons. Three likely candidates are neurons containing kisspeptin, neurokinin B (NKB) and orphanin FQ (OFQ).;Puberty in the ewe is marked by an increase in GnRH/LH secretion which in part results from a lessening of estradiol negative feedback. Kisspeptin and NKB are coexpressed in the same subsets of neurons in the arcuate nucleus (ARC) of the hypothalamus and are proposed to be critical for normal timing of puberty. Given that greater than 95% of kisspeptin/NKB neurons colocalize with estrogen receptor-alpha (ERalpha) and progesterone receptor in the ewe, we examined changes in kisspeptin- and NKB-positive neurons in the ARC of pre- and postpubertal ewes in the presence and absence of sex steroids. We observed a greater number of kisspeptin, but not NKB, positive neurons in the ARC of postpubertal ewes compared to prepubertal ewes, which corresponded with changes in LH secretion. Also, we showed that an intravenous injection of senktide, an NKB receptor agonist, stimulates LH secretion in prepubertal ewes. These results support a role for kisspeptin and NKB in ovine puberty.;OFQ when given centrally has been shown to inhibit LH secretion in rats and ewes and OFQ localizes to the external zone of the median eminence. Given its effect on LH secretion and its location, we investigated whether OFQ acts at the pituitary to inhibit LH release and/or at the hypothalamus to inhibit GnRH secretion. OFQ had no direct influence on ovine anterior pituitary cells in cell culture. However, we did observe a decrease in GnRH secretion in hypophyseal portal blood samples following infusion of an OFQ agonist into the third cerebroventricle of ovariectomized ewes. From this we conclude that OFQ acts centrally at the hypothalamus to inhibit GnRH secretion.;Given its central inhibitory action on GnRH secretion in the ewe, we examined if OFQ neurons in the preoptic area (POA) and hypothalamus contain steroid receptors. Furthermore, we investigated a role for endogenous OFQ by infusing an OFQ receptor antagonist into steroid-treated ewes. POA OFQ neurons did not contain steroid receptors, while a majority of OFQ neurons in the ARC contained both ERalpha and progesterone receptor. Furthermore, ovariectomized (OVX) ewes with luteal phase concentrations of progesterone and estradiol, but not OVX ewes implanted with only estradiol or ovary-intact anestrous ewes, showed a significant increase in LH pulse frequency during infusion of an OFQ receptor antagonist. Therefore, we conclude that OFQ mediates, at least in part,… Advisors/Committee Members: Robert L Goodman.

Subjects/Keywords: Physiology; Neurosciences; Endocrinology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Nestor, C. C. (2012). Evidence of a Role for Three Neuropeptides that Mediate Steroid Negative Feedback on Gonadotropin Releasing Hormone/Luteinizing Hormone Secretion in the Ewe: Kisspeptin, Neurokinin B and Orphanin FQ. (Doctoral Dissertation). West Virginia University. Retrieved from https://doi.org/10.33915/etd.4903 ; https://researchrepository.wvu.edu/etd/4903

Chicago Manual of Style (16^th Edition):

Nestor, Casey C. “Evidence of a Role for Three Neuropeptides that Mediate Steroid Negative Feedback on Gonadotropin Releasing Hormone/Luteinizing Hormone Secretion in the Ewe: Kisspeptin, Neurokinin B and Orphanin FQ.” 2012. Doctoral Dissertation, West Virginia University. Accessed January 18, 2021. https://doi.org/10.33915/etd.4903 ; https://researchrepository.wvu.edu/etd/4903.

MLA Handbook (7^th Edition):

Nestor, Casey C. “Evidence of a Role for Three Neuropeptides that Mediate Steroid Negative Feedback on Gonadotropin Releasing Hormone/Luteinizing Hormone Secretion in the Ewe: Kisspeptin, Neurokinin B and Orphanin FQ.” 2012. Web. 18 Jan 2021.

Vancouver:

Nestor CC. Evidence of a Role for Three Neuropeptides that Mediate Steroid Negative Feedback on Gonadotropin Releasing Hormone/Luteinizing Hormone Secretion in the Ewe: Kisspeptin, Neurokinin B and Orphanin FQ. [Internet] [Doctoral dissertation]. West Virginia University; 2012. [cited 2021 Jan 18]. Available from: https://doi.org/10.33915/etd.4903 ; https://researchrepository.wvu.edu/etd/4903.

Council of Science Editors:

Nestor CC. Evidence of a Role for Three Neuropeptides that Mediate Steroid Negative Feedback on Gonadotropin Releasing Hormone/Luteinizing Hormone Secretion in the Ewe: Kisspeptin, Neurokinin B and Orphanin FQ. [Doctoral Dissertation]. West Virginia University; 2012. Available from: https://doi.org/10.33915/etd.4903 ; https://researchrepository.wvu.edu/etd/4903

Florida State University

30. Fletcher, Patrick Allen. Theoretical, Computational, and Experimental Topics in Anterior Pituitary Cell Signaling.

Degree: PhD, Mathematics, 2015, Florida State University

URL: http://purl.flvc.org/fsu/fd/FSU_migr_etd-9598 ;

► The neuroendocrine system presents a diversity of patterns in hormone secretion across a large range of temporal scales. These patterns of secretion are crucial to… (more)

▼ The neuroendocrine system presents a diversity of patterns in hormone secretion across a large range of temporal scales. These patterns of secretion are crucial to many aspects of animal survival and behavior. This offers a wealth of important and interesting topics of study amenable to theoretical, experimental, and computational approaches. The pituitary gland plays a large role in neuroendocrine physiology by decoding signals from the brain, translating those signals and relaying them to the glands and tissues of the body via the circulatory system. The cells of the anterior pituitary gland use a diverse set of biochemical processes to accomplish this task. The first step is the activation of a hormone receptor, which convert an extracellular signal to an intracellular one. These receptors in turn trigger cascades of chemical reactions involving enzymes and intracellular messengers, as well as changes in membrane potential dynamics and intracellular Ca2+ ion concentrations, all of which are important in controlling the production and secretion of hormones at appropriate levels. The first portion of this dissertation studies how such biochemical systems respond to patterned inputs, such as pulsatile patterns that are characteristic of hormones in the reproductive system, growth hormone, and stress-responsive hormones. We examine how models of some common intracellular signaling components such as receptor binding and protein phosphorylation respond to pulsed inputs. We then study how a preference for a specific input pulse frequency may arise from the interactions between transcription factors, which are molecules regulating the expression of genes and in this case responsible for production of a hormone. The next portion of this work describes experiments performed to demonstrate the direct actions of a hormone, oxytocin, on three pituitary cell types. Intracellular Ca2+ ion concentration was measured in primary cultured female rat pituitary cells in vitro using video microscopy and a fluorescent \ca-sensitive dye. Oxytocin triggered increases in intracellular Ca2+ concentration as well as secretion of hormone from gonadotrophs, somatotrophs, and lactotrophs in a manner consistent with a direct action via the oxytocin receptor. Finally, computational tools are presented for harnessing the computational power of graphics processing units to rapidly compute numerical solutions to initial value problems such as those that arise in the study of pituitary cell electrophysiology. This provides tools for more rapid model exploration by computing the ensembles of parameter combinations required in parameter sweep and parameter space sampling computations in parallel. This allows rapid computations to be performed on inexpensive modern desktop or laptop computers. As a case study, we use a model of membrane potential dynamics of pituitary lactotroph cells, which is produces spiking and bursting patterns. We compare the actions of three K+ channel conductances known to be increased by the action of the hormone dopamine in… Advisors/Committee Members: R. (Richard) Bertram (professor co-directing dissertation), Joel Tabak-Sznajder (professor co-directing dissertation), Wei Yang (university representative), Nicholas G. Cogan (committee member), Michael V. Mascagni (committee member), Washington Mio (committee member).

Subjects/Keywords: Mathematics; Cytology; Endocrinology

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APA (6^th Edition):

Fletcher, P. A. (2015). Theoretical, Computational, and Experimental Topics in Anterior Pituitary Cell Signaling. (Doctoral Dissertation). Florida State University. Retrieved from http://purl.flvc.org/fsu/fd/FSU_migr_etd-9598 ;

Chicago Manual of Style (16^th Edition):

Fletcher, Patrick Allen. “Theoretical, Computational, and Experimental Topics in Anterior Pituitary Cell Signaling.” 2015. Doctoral Dissertation, Florida State University. Accessed January 18, 2021. http://purl.flvc.org/fsu/fd/FSU_migr_etd-9598 ;.

MLA Handbook (7^th Edition):

Fletcher, Patrick Allen. “Theoretical, Computational, and Experimental Topics in Anterior Pituitary Cell Signaling.” 2015. Web. 18 Jan 2021.

Vancouver:

Fletcher PA. Theoretical, Computational, and Experimental Topics in Anterior Pituitary Cell Signaling. [Internet] [Doctoral dissertation]. Florida State University; 2015. [cited 2021 Jan 18]. Available from: http://purl.flvc.org/fsu/fd/FSU_migr_etd-9598 ;.

Council of Science Editors:

Fletcher PA. Theoretical, Computational, and Experimental Topics in Anterior Pituitary Cell Signaling. [Doctoral Dissertation]. Florida State University; 2015. Available from: http://purl.flvc.org/fsu/fd/FSU_migr_etd-9598 ;

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