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University of Western Ontario

1. Khazaee, Tina. Characterization and Enhancement of Local Drug Delivery in Orthopaedic Infection.

Degree: 2020, University of Western Ontario

The delivery of antibiotics is an important component of therapy for orthopedic device-related infections (ODRI). In this study, we have investigated new techniques to characterize and enhance antibiotic delivery for ODRI. Characterization of small-molecule diffusion is essential to the development of drug-delivery systems. We have developed a quantitative, non-invasive, longitudinal, micro-CT technique to quantify the diffusion of small-molecules in an intact phantom. We employed a radio-opaque molecule (i.e., Iohexol) as a surrogate for commonly used antibiotics (e.g., Vancomycin). We characterized diffusion from a finite-core carrier into an agar, tissue-equivalent phantom. The estimate of the diffusion coefficient was derived from the analysis of radial diffusion distance of Iohexol and the cumulative release amount of this drug surrogate. This micro-CT method enabled us to describe the elution of small-molecules from enhanced carriers within a porous metal scaffold. To enhance antibiotic delivery, we designed and fabricated gyroid-based scaffolds with appropriate mechanical properties and filled with Iohexol-loaded carriers. Diffusion characteristics within the porous structures were evaluated using the micro-CT technique.

Subjects/Keywords: Diffusion; small-molecules; local drug delivery; micro-CT; drug-surrogate; contrast agent; orthopedic device-related infection; 3D-printed porous scaffold.; Medical Biophysics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Khazaee, T. (2020). Characterization and Enhancement of Local Drug Delivery in Orthopaedic Infection. (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/6851

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Khazaee, Tina. “Characterization and Enhancement of Local Drug Delivery in Orthopaedic Infection.” 2020. Thesis, University of Western Ontario. Accessed October 29, 2020. https://ir.lib.uwo.ca/etd/6851.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Khazaee, Tina. “Characterization and Enhancement of Local Drug Delivery in Orthopaedic Infection.” 2020. Web. 29 Oct 2020.

Vancouver:

Khazaee T. Characterization and Enhancement of Local Drug Delivery in Orthopaedic Infection. [Internet] [Thesis]. University of Western Ontario; 2020. [cited 2020 Oct 29]. Available from: https://ir.lib.uwo.ca/etd/6851.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Khazaee T. Characterization and Enhancement of Local Drug Delivery in Orthopaedic Infection. [Thesis]. University of Western Ontario; 2020. Available from: https://ir.lib.uwo.ca/etd/6851

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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