You searched for subject:(diagnostic).
Showing records 1 – 30 of
3629 total matches.
◁ [1] [2] [3] [4] [5] … [121] ▶
1.
Totaro, Kyle A.
Development of New Chemical Approaches for Diagnostic
Medicine and for Syntheses of Antibacterial Agents.
Degree: PhD, Chemistry, 2014, Brown University
URL: https://repository.library.brown.edu/studio/item/bdr:386279/ 
► Medicine can be divided into two central components: the diagnosis of a disease and its treatment. Both components of medicine are being transformed by the…
(more)
▼ Medicine can be divided into two central components:
the diagnosis of a disease and its treatment. Both components of
medicine are being transformed by the availability of new “omics”
technologies in which gene, proteins, and metabolites are
holistically analyzed and measured. At the center of these “omics”
technologies are the principles of chemistry and ingeniously
designed chemical reagents. It is my contention that chemistry will
continue to play a critical role in the diagnosis and treatment of
disease. The work in this thesis describes new chemical methods for
disease diagnosis via metabolomics and the synthesis of
antibacterial drug candidates identified via genomics. We
demonstrate that a multicomponent reaction can be used to
chemoselectively derivatize a wide range of metabolites, including
amino acids, neurotransmitters, hormones, intermediates in central
metabolism, and co-factors. The potential of this technology for
disease diagnosis is highlighted in the derivatization and
detection of metabolites associated with the metabolic disorder,
Phenylketonuria. While it also describes the development of new
methodologies for the syntheses of peptide antibiotics discovered
in a traditional screen for antibacterial agents, this thesis
illustrates how “omics” technologies can inform antibacterial drug
discovery and development. Specifically, it depicts the rational
design and synthesis of species-selective inhibitors of the
mycobacterial proteasome, a tuberculosis drug target identified via
state-of-the art genomic approaches. Collectively, the results in
the thesis illustrate how chemistry can be transformative in both
disease diagnosis and drug development.
Advisors/Committee Members: Sello, Jason (Director), Basu, Amit (Reader), Delaney, Sarah (Reader).
Subjects/Keywords: Diagnostic Medicine
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Totaro, K. A. (2014). Development of New Chemical Approaches for Diagnostic
Medicine and for Syntheses of Antibacterial Agents. (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:386279/
Chicago Manual of Style (16th Edition):
Totaro, Kyle A. “Development of New Chemical Approaches for Diagnostic
Medicine and for Syntheses of Antibacterial Agents.” 2014. Doctoral Dissertation, Brown University. Accessed February 27, 2021.
https://repository.library.brown.edu/studio/item/bdr:386279/.
MLA Handbook (7th Edition):
Totaro, Kyle A. “Development of New Chemical Approaches for Diagnostic
Medicine and for Syntheses of Antibacterial Agents.” 2014. Web. 27 Feb 2021.
Vancouver:
Totaro KA. Development of New Chemical Approaches for Diagnostic
Medicine and for Syntheses of Antibacterial Agents. [Internet] [Doctoral dissertation]. Brown University; 2014. [cited 2021 Feb 27].
Available from: https://repository.library.brown.edu/studio/item/bdr:386279/.
Council of Science Editors:
Totaro KA. Development of New Chemical Approaches for Diagnostic
Medicine and for Syntheses of Antibacterial Agents. [Doctoral Dissertation]. Brown University; 2014. Available from: https://repository.library.brown.edu/studio/item/bdr:386279/
KTH
2.
Malakhatka, Elena.
Diagnostics of valves on the gas pipeline.
Degree: Heat and Power Technology, 2012, KTH
URL: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-101377
► The work of the gas transmission pipeline system is regulated by the thousands of valveses and other elements of the shut-off valves, located in…
(more)
▼ The work of the gas transmission pipeline system is regulated by the thousands of valveses and other elements of the shut-off valves, located in different places. Information about the current status of each valve, and confidence in its technical serviceability is an important element in the control of pipeline system. There are a number of problems that adversely affect the valving operation. Principal among them - is the lack of siystematical approach in valving diagnostics. To solve this problem, developed a new approach to the valving diagnostics – multi-level diagnostics. Depending on the level of diagnosis, we get a different amount of information about the object. The focus is on the 3rd level of diagnosis, which allows to determine the leackages of valves, and identify type of defects quantitatively. This level of diagnosis is regarded as an example of Method «Micropuls». The method «Micropuls» based on the theory of mechanical vibrations and forced with high accuracy to set the time, frequency and spectral characteristics of noise in the details of the valve, and their spatial location and intensity of that in the presence of a system of analysis allows to determine the state of the object, its faults and defects. Micropulse technology is based on the impact on the measured object micropower impulses, records the response and subsequent filtering, decoding and analyzing the data. Specially designed calibrated pulses can effectively influence the measured objects (valve) over a wide range of structural dimensions and mounting schemes, regardless of physical location of the valve.
Subjects/Keywords: valves; diagnostic
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Malakhatka, E. (2012). Diagnostics of valves on the gas pipeline. (Thesis). KTH. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-101377
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Malakhatka, Elena. “Diagnostics of valves on the gas pipeline.” 2012. Thesis, KTH. Accessed February 27, 2021.
http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-101377.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Malakhatka, Elena. “Diagnostics of valves on the gas pipeline.” 2012. Web. 27 Feb 2021.
Vancouver:
Malakhatka E. Diagnostics of valves on the gas pipeline. [Internet] [Thesis]. KTH; 2012. [cited 2021 Feb 27].
Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-101377.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Malakhatka E. Diagnostics of valves on the gas pipeline. [Thesis]. KTH; 2012. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-101377
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of KwaZulu-Natal
3.
Moodley, Revesa Sadasivan.
Evaluation of paper substrates for microfluidic application in medical diagnostic kits.
Degree: 2018, University of KwaZulu-Natal
URL: https://researchspace.ukzn.ac.za/handle/10413/16613
► Recent studies in the biomedical field have shown the use of paper in microfluidic analytical devices. However, no studies have been undertaken to ascertain what…
(more)
▼ Recent studies in the biomedical field have shown the use of paper in microfluidic analytical devices. However, no studies have been undertaken to ascertain what type(s) of paper substrates are ideal for such microfluidic applications. Hence, this study was conducted to determine the feasibility of using different paper substrates for implementation in microfluidic analytical devices, specifically in the South African context, compared to currently used materials such as glass and silicone. In addition, fibres in paper substrates were substituted with nanofibrillated cellulose (NFC) fibres to ascertain the impact of NFC on the microfluidics of the paper substrates. The wicking rate of the substrates was the focus of the study, with high -resolution field emission gun-scanning electron microscopy and contact angle tests being used to support the results obtained. Solid wax printing was also conducted to determine whether the paper substrates were suited to fabrication for microfluidic applications.
High-resolution morphological studies of the paper substrates showed that pore sizes of the pulp fibres were in the order sulphite> bleached kraft > unbleached kraft > Whatman No. 1 Chromatography Filter Paper > Whatman 3MM Chromatography Filter Paper > thermo-mechanical > recycled. It was concluded that the larger pore size of fibres correlated with faster wicking rates of the relevant paper substrates. The substitution of pulp fibres with NFC led to reduced pore size of the fibres thus leading to reduced wicking rates due to the presence of the small NFC particles.
Contact angle is directly linked to the hydrophobicity of the substrate and is indicative of the resistance to absorption of a liquid. The results revealed that all the paper substrates were hydrophilic. However, the hydrophilicity of two of the substrates (sheets substituted with 100% NFC unbleached kraft pulp and 100% NFC recycled pulp) were higher than those of the other substrates indicating that, although these substrates were still hydrophilic in nature, their absorption of aqueous liquid would take longer periods of time.
The results showed that Whatman glass microfiber GF/D filter paper was the fastest wicking substrate, using both dye and blood simulant as wicking liquids. Similarly, paper substrates made with recycled fibres exhibited the slowest wicking rates when using both wicking liquids. These results can be used when determining which of the substrates to use for paper-based microfluidic device (μPAD) application, whereby the desired detection time would be the factor used to establish which of the substrates to use. Comparison of vertical and horizontal tests showed varying results. In theory, the horizontal wicking test should result in a faster wicking rate than the vertical test, taking hydrostatic pressure into consideration. The majority of the substrates showed that the horizontal wicking rate was faster when using the dye solution, whereas vertical wicking was faster when using the blood simulant. Discrepancies between the results…
Advisors/Committee Members: Land, Kevin. (advisor), Sithole, Bishop Bruce. (advisor), Van Zyl, Werner Ewald. (advisor), Andrew, Jerome. (advisor).
Subjects/Keywords: MICROFLUIDIC.; DIAGNOSTIC.
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Moodley, R. S. (2018). Evaluation of paper substrates for microfluidic application in medical diagnostic kits. (Thesis). University of KwaZulu-Natal. Retrieved from https://researchspace.ukzn.ac.za/handle/10413/16613
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Moodley, Revesa Sadasivan. “Evaluation of paper substrates for microfluidic application in medical diagnostic kits.” 2018. Thesis, University of KwaZulu-Natal. Accessed February 27, 2021.
https://researchspace.ukzn.ac.za/handle/10413/16613.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Moodley, Revesa Sadasivan. “Evaluation of paper substrates for microfluidic application in medical diagnostic kits.” 2018. Web. 27 Feb 2021.
Vancouver:
Moodley RS. Evaluation of paper substrates for microfluidic application in medical diagnostic kits. [Internet] [Thesis]. University of KwaZulu-Natal; 2018. [cited 2021 Feb 27].
Available from: https://researchspace.ukzn.ac.za/handle/10413/16613.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Moodley RS. Evaluation of paper substrates for microfluidic application in medical diagnostic kits. [Thesis]. University of KwaZulu-Natal; 2018. Available from: https://researchspace.ukzn.ac.za/handle/10413/16613
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Cape Town
4.
Richter-Joubert, Lisel.
Assessment of airway compression on chest radiographs in children with pulmonary tuberculosis.
Degree: MMed, Division of Radiology, 2018, University of Cape Town
URL: http://hdl.handle.net/11427/29690
► Study rationale: Diagnosis of pulmonary tuberculosis (PTB) in children relies heavily on chest radiography as sputum samples are difficult to obtain and only yield positive…
(more)
▼ Study rationale: Diagnosis of pulmonary tuberculosis (PTB) in children relies heavily on chest radiography as sputum samples are difficult to obtain and only yield positive results in 30-74% of children treated for PTB. However, radiological signs between lower respiratory tract infections (LRTI) and PTB overlap considerably and there is a wide inter-observer agreement in the detection of lymphadenopathy, considered the hallmark of PTB. Small pliable paediatric airways are easily compressed by enlarged lymph nodes. Unlike lymph nodes, however, the lucent airways contrast against the surrounding mediastinal structures on radiographs, thus airway compression may serve as a more objective criterion for diagnosing PTB. Many studies have reviewed the radiographic features of PTB in children but few included airway compression or used a control group and none have evaluated inter-observer agreement. Objective: To investigate frequency and inter-observer agreement of airway compression on chest radiographs in children with PTB compared to those with another LRTI. Methods: Chest radiographs of children admitted to Red Cross War Memorial Children’s Hospital with suspected PTB were read by two readers according to a standardised format and a 3rd when there was disagreement. Radiographs of children with definite PTB were compared to those with another LRTI. Frequency and location of airway compression were evaluated. Findings were correlated with human immunodeficiency virus (HIV) infection and age. Inter-observer agreement was assessed using kappa statistic. Results: Radiographs of 505 children (median age 25.9 months [IQR 14.3-62.2]) were reviewed; 97/505 (19%) children were HIV-infected. Airway compression occurred in 54/188 (28.7%) definite PTB cases versus 24/317 (7.6 %) of other LRTI cases (OR 4.9; 95%CI 2.9–8.3). The left main bronchus was most affected in 51/493 (10.3%). A higher frequency of airway compression occurred in infants at 22/101 (21.8%) compared to 56/404 (13.9%) in older children (OR 1.7; 95%CI 1.00–3.00). No association between airway compression and HIV infection was found. Inter-observer agreement ranged from none to fair (kappa of 0.0-0.4). Discussion: The overall frequency of airway compression in definite PTB is compatible with reports in the literature. Although airway compression used alone is not a specific sign, if seen on radiographs, there is a strong correlation with PTB compared to other LRTI with infants at higher risk due to their smaller airways. Contradictory to other studies, our study showed the left main bronchus to be affected twice more commonly than the bronchus intermedius in both age groups. This is thought to be due to different patient selection. Confirming reports in the literature, no significant association between airway compression and HIV status was found. A disappointing finding was the poor inter-observer agreement. Contributing aspects include the lack of standardised criteria in the definition of airway compression and suboptimal visualisation of the airways on standard…
Subjects/Keywords: Diagnostic Radiology
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Richter-Joubert, L. (2018). Assessment of airway compression on chest radiographs in children with pulmonary tuberculosis. (Thesis). University of Cape Town. Retrieved from http://hdl.handle.net/11427/29690
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Richter-Joubert, Lisel. “Assessment of airway compression on chest radiographs in children with pulmonary tuberculosis.” 2018. Thesis, University of Cape Town. Accessed February 27, 2021.
http://hdl.handle.net/11427/29690.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Richter-Joubert, Lisel. “Assessment of airway compression on chest radiographs in children with pulmonary tuberculosis.” 2018. Web. 27 Feb 2021.
Vancouver:
Richter-Joubert L. Assessment of airway compression on chest radiographs in children with pulmonary tuberculosis. [Internet] [Thesis]. University of Cape Town; 2018. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/11427/29690.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Richter-Joubert L. Assessment of airway compression on chest radiographs in children with pulmonary tuberculosis. [Thesis]. University of Cape Town; 2018. Available from: http://hdl.handle.net/11427/29690
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Cape Town
5.
Raubenheimer, Lauren.
Corpus callosum morphology in children on mid-sagittal MR imaging.
Degree: MMed, Division of Radiology, 2018, University of Cape Town
URL: http://hdl.handle.net/11427/29692
► Background: There is little published research on the wide variation of corpus callosum (CC) morphology in children, the assessment of which is made difficult by…
(more)
▼ Background: There is little published research on the wide variation of corpus callosum (CC) morphology in children, the assessment of which is made difficult by the complex alteration of its appearance in childhood. Objective: The purpose of our study was to assess the morphology of the CC on mid-sagittal T1- weighted magnetic resonance imaging (MRI) in a large number of children and correlate the findings with demographic and clinical criteria. Materials and methods: We reviewed all brain mid-sagittal T1-weighted MRI’s performed from July to December 2015 and obtained relevant demographic and clinical information from the accompanying report and laboratory system. The CC morphology was analysed by three radiologists and compared using cross tabulation with the chi-square test and ANOVA. Interobserver correlation was assessed using Kappa coefficient of conformance. Results: 257 patients with mean age 72±60 months were included, 142 were male (55%). In abnormal MRI’s the CC was less likely to have an identifiable isthmus and was more likely to be convex, thin and have separation of the fornix insertion (all p<0.01). In young children (< 5 years) the CC was also less likely to have an identifiable isthmus (p=0.01) and was more likely to be convex (p=0.04) but the fornix was more likely to insert normally (p<0.01). Children with tuberous sclerosis had significantly thinner splenia (p=0.02). Conclusion: There is a distinct pathological appearance of the CC. The immature appearance of the corpus callosum can mirror this but is distinguished by normal insertion of the fornix and normal quantitative measurements. Splenial thinning in children with tuberous sclerosis warrants further investigation.
Advisors/Committee Members: Andronikou, Savvas (advisor), Kilborn,Tracy (advisor).
Subjects/Keywords: Diagnostic Radiology
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Raubenheimer, L. (2018). Corpus callosum morphology in children on mid-sagittal MR imaging. (Thesis). University of Cape Town. Retrieved from http://hdl.handle.net/11427/29692
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Raubenheimer, Lauren. “Corpus callosum morphology in children on mid-sagittal MR imaging.” 2018. Thesis, University of Cape Town. Accessed February 27, 2021.
http://hdl.handle.net/11427/29692.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Raubenheimer, Lauren. “Corpus callosum morphology in children on mid-sagittal MR imaging.” 2018. Web. 27 Feb 2021.
Vancouver:
Raubenheimer L. Corpus callosum morphology in children on mid-sagittal MR imaging. [Internet] [Thesis]. University of Cape Town; 2018. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/11427/29692.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Raubenheimer L. Corpus callosum morphology in children on mid-sagittal MR imaging. [Thesis]. University of Cape Town; 2018. Available from: http://hdl.handle.net/11427/29692
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Cape Town
6.
Ncube, Innocent Vusumusi.
Evaluating the yield of brain CT examinations in patients presenting with first onset seizures at the Groote Schuur Hospital, Cape Town.
Degree: MMed, Division of Radiology, 2019, University of Cape Town
URL: http://hdl.handle.net/11427/31818
► Background: Seizures are a frequent and potentially significant presenting complaint to the emergency department (ED). Determining the underlying cause for seizures is important in guiding…
(more)
▼ Background: Seizures are a frequent and potentially significant presenting complaint to the emergency department (ED). Determining the underlying cause for seizures is important in guiding further clinical management of patients. ED physicians at Groote Schuur Hospital, Cape Town, South Africa routinely request Computed Tomography (CT) brain scans in the work-up of patients presenting with first onset seizures. Objectives: To determine the number and proportion of CT scan examinations with abnormal findings in patients presenting with first onset seizures at the Groote Schuur Hospital ED, Cape Town, South Africa and to identify the range of CT abnormalities. Method: A retrospective study was carried out in the Division of Radiology, Groote Schuur Hospital. Patients who presented to the ED with first onset seizures and who underwent brain CT examination as part of their work up between 1 January 2013 and 31 December 2016 were enrolled. All patients presenting to the ED with first onset focal or grand mal seizures were included. Patients with recent trauma and those with previously diagnosed epilepsy were excluded. Results: A total of 200 patients were eligible for the study. Of these, 92 (46%) patients with first onset seizures had an abnormality or abnormalities on brain CT scan. Of those patients whose HIV status was known, 50% of HIV positive and 53% of HIV negative patients had abnormal CT scans. 54% of patients with focal seizures and 38% with generalised seizures had an abnormality on CT scan. Abnormalities found on CT scans included chronic cerebral infarction (7.5%), acute or subacute cerebral infarction (4.5%), neurocysticercosis (7.0%), other infections (6.5%), haemorrhage and other vascular lesions (6.5%), post-traumatic encephalomalacia (6.5%), primary brain tumours and metastases (based on CT characteristics) (7.0%). Conclusion: Forty-six (46%) of patients presenting to the Groote Schuur Hospital ED, Cape Town, South Africa with first onset seizures had an abnormality on their brain CT scans. Brain CT scan is therefore recommended in patients presenting to the ED department with first-onset seizures, irrespective of their HIV/ neurological status.
Advisors/Committee Members: Ahmed, Nazir (advisor).
Subjects/Keywords: Diagnostic Radiology
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Ncube, I. V. (2019). Evaluating the yield of brain CT examinations in patients presenting with first onset seizures at the Groote Schuur Hospital, Cape Town. (Thesis). University of Cape Town. Retrieved from http://hdl.handle.net/11427/31818
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Ncube, Innocent Vusumusi. “Evaluating the yield of brain CT examinations in patients presenting with first onset seizures at the Groote Schuur Hospital, Cape Town.” 2019. Thesis, University of Cape Town. Accessed February 27, 2021.
http://hdl.handle.net/11427/31818.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Ncube, Innocent Vusumusi. “Evaluating the yield of brain CT examinations in patients presenting with first onset seizures at the Groote Schuur Hospital, Cape Town.” 2019. Web. 27 Feb 2021.
Vancouver:
Ncube IV. Evaluating the yield of brain CT examinations in patients presenting with first onset seizures at the Groote Schuur Hospital, Cape Town. [Internet] [Thesis]. University of Cape Town; 2019. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/11427/31818.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Ncube IV. Evaluating the yield of brain CT examinations in patients presenting with first onset seizures at the Groote Schuur Hospital, Cape Town. [Thesis]. University of Cape Town; 2019. Available from: http://hdl.handle.net/11427/31818
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Cape Town
7.
De Vos, Hendrik Johannes.
Radiation dose optimization in interventional radiology and cardiology using diagnostic reference levels.
Degree: Image, Division of Medical Physics, 2016, University of Cape Town
URL: http://hdl.handle.net/11427/20928
► The International Commission of Radiological Protection (ICRP) advises that in principle Diagnostic Reference Levels (DRL) could be used in fluoroscopically guided interventional procedures to avoid…
(more)
▼ The International Commission of Radiological Protection (ICRP) advises that in principle
Diagnostic Reference Levels (DRL) could be used in fluoroscopically guided interventional procedures to avoid unnecessary stochastic radiation risk. The increase in complexity of interventional procedures, combined with a lack of specialist training on radiation techniques, poses a significant risk to patients. These risks have not gone unnoticed by government authorities worldwide and in 2015 the South African Department of Health: Directorate Radiation Control issued requirements to license holders of interventional fluoroscopy units, requiring that a medical physicist optimize their radiation usage using DRLs. The Dose Area Product (DAP) quantity measured for each patient represents a dosimetry index, the value of which for the purpose of improvement should be optimized against the DRL. In this dissertation, I aim to establish if DRLs in the South African private healthcare interventional theatres are high compared to international levels and whether DRLs will optimize the doses used.
Advisors/Committee Members: Trauernicht, Christoph Jan (advisor), Kotzé, T C (advisor).
Subjects/Keywords: Diagnostic Radiology
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
De Vos, H. J. (2016). Radiation dose optimization in interventional radiology and cardiology using diagnostic reference levels. (Thesis). University of Cape Town. Retrieved from http://hdl.handle.net/11427/20928
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
De Vos, Hendrik Johannes. “Radiation dose optimization in interventional radiology and cardiology using diagnostic reference levels.” 2016. Thesis, University of Cape Town. Accessed February 27, 2021.
http://hdl.handle.net/11427/20928.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
De Vos, Hendrik Johannes. “Radiation dose optimization in interventional radiology and cardiology using diagnostic reference levels.” 2016. Web. 27 Feb 2021.
Vancouver:
De Vos HJ. Radiation dose optimization in interventional radiology and cardiology using diagnostic reference levels. [Internet] [Thesis]. University of Cape Town; 2016. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/11427/20928.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
De Vos HJ. Radiation dose optimization in interventional radiology and cardiology using diagnostic reference levels. [Thesis]. University of Cape Town; 2016. Available from: http://hdl.handle.net/11427/20928
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Cape Town
8.
Lawson, Andrew James.
Imaging displacement and strain in the medial gastrocnemius muscle during ankle-joint motion using 2D-ciné DENSE MRI.
Degree: Image, Division of Radiology, 2011, University of Cape Town
URL: http://hdl.handle.net/11427/11758
► Skeletal muscle structure has been defined on both macro and microscopic levels by gross dissection, light- and electron-microscopy. The basic physiological building blocks involve the…
(more)
▼ Skeletal muscle structure has been defined on both macro and microscopic levels by gross dissection, light- and electron-microscopy. The basic physiological building blocks involve the electromechanical coupling between interlinking actin and myosin fibres. Detailed intramuscular behaviour during contraction can be clearly defined when examining a single isolated muscle. However, there are few areas in the human body where single muscles act independently to affect motion. This thesis attempts to address the compounded effect that muscles have on each other, while working synergistically in a group, such as the calf muscle.
Advisors/Committee Members: Beningfield, Stephen J (advisor), Spottiswoode, Bruce Shawn (advisor).
Subjects/Keywords: Diagnostic Radiology
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Lawson, A. J. (2011). Imaging displacement and strain in the medial gastrocnemius muscle during ankle-joint motion using 2D-ciné DENSE MRI. (Thesis). University of Cape Town. Retrieved from http://hdl.handle.net/11427/11758
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Lawson, Andrew James. “Imaging displacement and strain in the medial gastrocnemius muscle during ankle-joint motion using 2D-ciné DENSE MRI.” 2011. Thesis, University of Cape Town. Accessed February 27, 2021.
http://hdl.handle.net/11427/11758.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Lawson, Andrew James. “Imaging displacement and strain in the medial gastrocnemius muscle during ankle-joint motion using 2D-ciné DENSE MRI.” 2011. Web. 27 Feb 2021.
Vancouver:
Lawson AJ. Imaging displacement and strain in the medial gastrocnemius muscle during ankle-joint motion using 2D-ciné DENSE MRI. [Internet] [Thesis]. University of Cape Town; 2011. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/11427/11758.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Lawson AJ. Imaging displacement and strain in the medial gastrocnemius muscle during ankle-joint motion using 2D-ciné DENSE MRI. [Thesis]. University of Cape Town; 2011. Available from: http://hdl.handle.net/11427/11758
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Cape Town
9.
Davis, Razaan.
Radiological features of psoriatic arthritis.
Degree: Image, Division of Radiology, 2011, University of Cape Town
URL: http://hdl.handle.net/11427/10338
► Psoriatic arthritis (PsA) is an inflammatory arthritis associated with psoriasis. Psoriasis is a dermatological condition that affects 1-2% of the population. Approximately 10-15% of patients…
(more)
▼ Psoriatic arthritis (PsA) is an inflammatory arthritis associated with psoriasis. Psoriasis is a dermatological condition that affects 1-2% of the population. Approximately 10-15% of patients with skin manifestations of psoriasis develop PsA and 0.3-1% of the general population. Moll and Wright defined PsA as psoriasis associated with inflammatory arthritis and usually a negative serological test for rheumatoid factor (RF).
Advisors/Committee Members: Kalla, A A (advisor).
Subjects/Keywords: Diagnostic Radiology
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Davis, R. (2011). Radiological features of psoriatic arthritis. (Thesis). University of Cape Town. Retrieved from http://hdl.handle.net/11427/10338
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Davis, Razaan. “Radiological features of psoriatic arthritis.” 2011. Thesis, University of Cape Town. Accessed February 27, 2021.
http://hdl.handle.net/11427/10338.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Davis, Razaan. “Radiological features of psoriatic arthritis.” 2011. Web. 27 Feb 2021.
Vancouver:
Davis R. Radiological features of psoriatic arthritis. [Internet] [Thesis]. University of Cape Town; 2011. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/11427/10338.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Davis R. Radiological features of psoriatic arthritis. [Thesis]. University of Cape Town; 2011. Available from: http://hdl.handle.net/11427/10338
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Cape Town
10.
Owen, Jeannine Margaret.
Value of follow-up CT in head injury assessment.
Degree: Image, Division of Radiology, 2015, University of Cape Town
URL: http://hdl.handle.net/11427/15682
► INTRODUCTION: The question of when and if to perform follow- up CT scanning of the brain in a patient with a proven head injury remains…
(more)
▼ INTRODUCTION: The question of when and if to perform follow- up CT scanning of the brain in a patient with a proven head injury remains pertinent, and the answer is not clear cut. This is even more so compounded when one tries to compare and equate what happens in a developed country with that of a developing country such as South Africa. AIM: To evaluate referral patterns, associated time-delays and findings of follow-up CT as well as patient outcomes in patients with head injury at Groote Schuur Hospital. METHOD: A retrospective review, over a 6 month time period, of the CT scans and folders belonging to patients who underwent follow-up CT scanning of the brain after blunt trauma to the head. RESULTS: There were 313 follow-up studies performed in 212 patients, of which the majority, 135 /313 (43.1%) were referred for neurological reasons, whilst 103/313 (32.9%) were referred for conservative management reasons and 75/313 (24%) were referred as part of their post-surgical check-up. There were significant time delays from arrival of patients in casualty to their initial CT scan (mean 18.74 hours) as well as between the initial CT and the first follow-up scan (mean 121.78 hours). There was a significant amount of data missing regarding the time of actual injury for many patients. There were 74 neurosurgical interventions that took place as a result of CT scans performed. Of these, 54 (73%) took place after the initial CT scan, whilst only 20 (27%) occurred after a follow-up CT. Of those surgical interventions performed after a follow- up study, 6 (30%) were performed as a result of a scan performed for post-surgical check- up. 12 (60%) were performed as a result of a scan performed for neurological reasons. Two (10%) neurosurgical interventions occurred as a result of a scan performed for conservative management reasons (thus routine follow-up imaging). CONCLUSIONS: A routine single follow-up CT may be a reasonable approach with further follow-up imaging reserved for patients who have undergone surgery, those with possibly surgically manageable findings on initial CT (that do not undergo surgery) and those with new neurology. The routine use of follow-up CT beyond the first follow-up CT is unlikely to lead to a change in management when the above clinical, and prior CT findings are absent. However, the time delays across all aspects of imaging traumatic brain injuries in our setting are unpredictable and represent a major problem in standardising when CT scans are performed.
Advisors/Committee Members: Andronikou, Savvas (advisor).
Subjects/Keywords: Diagnostic Radiology
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Owen, J. M. (2015). Value of follow-up CT in head injury assessment. (Thesis). University of Cape Town. Retrieved from http://hdl.handle.net/11427/15682
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Owen, Jeannine Margaret. “Value of follow-up CT in head injury assessment.” 2015. Thesis, University of Cape Town. Accessed February 27, 2021.
http://hdl.handle.net/11427/15682.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Owen, Jeannine Margaret. “Value of follow-up CT in head injury assessment.” 2015. Web. 27 Feb 2021.
Vancouver:
Owen JM. Value of follow-up CT in head injury assessment. [Internet] [Thesis]. University of Cape Town; 2015. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/11427/15682.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Owen JM. Value of follow-up CT in head injury assessment. [Thesis]. University of Cape Town; 2015. Available from: http://hdl.handle.net/11427/15682
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Cape Town
11.
Ho-Yee, Ruschka.
Evaluation of the utility of specific CXR features for diagnosis of pulmonary tuberculosis in young children using multiple readers.
Degree: Image, Division of Radiology, 2015, University of Cape Town
URL: http://hdl.handle.net/11427/16594
► INTRODUCTION: The diagnosis of childhood pulmonary tuberculosis (TB) can be notoriously difficult. The chest X-ray (CXR) is a significant diagnostic resource in the detection of…
(more)
▼ INTRODUCTION: The diagnosis of childhood pulmonary tuberculosis (TB) can be notoriously difficult. The chest X-ray (CXR) is a significant
diagnostic resource in the detection of PTB in children. However, non-specific radiological features combined with variable inter-observer assessment s contribute to
diagnostic uncertainty. The CXR would be of most value when used specifically to evaluate those features of childhood TB that it shows best and where expert observers agree, namely those signs indicating lymphadenopathy. AIM: To identify simple and reliable CXR features of primary TB in children by determining signs and anatomical sites of best observer agreement. METHOD: This is a retrospective descriptive study within a clinical trial performed by the South African TB Vaccine Initiative (SATVI). Healthy BCG-vaccinated newborn infants in a high TB prevalence rural area in Worcester, near Cape Town, South Africa, were followed for a minimum of two years for possible incident al pulmonary TB. Three independent, blinded, expert paediatric radiologists reported the resultant CXR images using a standardised data collection tick sheet, on which the specific anatomical sites and signs of pathology consistent with pulmonary TB were recorded. The first 200 original data collection tick sheets were sampled and recorded in a pre-compiled data spreadsheet for our study. The sampled data were t hen analysed using kappa statistics. RESULTS: The overall combined agreement for airway compression (by presumed lymphadenopathy) was 0.5%. Five % of the CXR's had soft tissue densities reflecting lymphadenopathy on the frontal view and 5% on the lateral view. The most common site reflecting lymphadenopathy through airway narrowing or displacement was the left main bronchus. The hilar region (kappa 0.27) on the frontal CXR and behind bronchus intermedius (kappa 0.18) on the lateral were the most common sites of soft tissue densities reflecting lymphadenopathy. There were no positive findings for cavitation or pleural effusion. The overall decisions reflecting PTB (lymphadenopathy or miliary) by each individual reader were 27.6% by Reader 1, 8.5% by Reader 2 and 24.6 % by Reader 3. Abnormal findings not specific for PTB were found in 3.5 % by Reader 1, 10.5% by Reader 2 and 3.5% by Reader 3.68. 3 % of the radiographs were reported as normal by Reader 1, 81.9% by Reader 2 and 66.8 % by Reader 3. Only 5% of the radiographs were found to be unreadable by one reader. The overall agreement of all three readers on PTB was 14.6 % and for normal CXR 49.2%. CONCLUSIONS: The fair degree of agreement amongst expert readers suggests that the CXR alone is not a reliable tool for detecting pulmonary TB and should be utilised in conjunction with the clinical features and/or skin tests and blood results. Soft tissue masses rather than airway compression are a more reliable sign for lymphadenopathy, with the most agreed upon sites on the frontal projection for soft tissue mass detection being the right hilar region, followed by the left hilum. Unfortunately,…
Advisors/Committee Members: Andronikou, Savvas (advisor), Beningfield, Stephen J (advisor), Hatherill, Mark (advisor).
Subjects/Keywords: Diagnostic Radiology
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Ho-Yee, R. (2015). Evaluation of the utility of specific CXR features for diagnosis of pulmonary tuberculosis in young children using multiple readers. (Thesis). University of Cape Town. Retrieved from http://hdl.handle.net/11427/16594
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Ho-Yee, Ruschka. “Evaluation of the utility of specific CXR features for diagnosis of pulmonary tuberculosis in young children using multiple readers.” 2015. Thesis, University of Cape Town. Accessed February 27, 2021.
http://hdl.handle.net/11427/16594.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Ho-Yee, Ruschka. “Evaluation of the utility of specific CXR features for diagnosis of pulmonary tuberculosis in young children using multiple readers.” 2015. Web. 27 Feb 2021.
Vancouver:
Ho-Yee R. Evaluation of the utility of specific CXR features for diagnosis of pulmonary tuberculosis in young children using multiple readers. [Internet] [Thesis]. University of Cape Town; 2015. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/11427/16594.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Ho-Yee R. Evaluation of the utility of specific CXR features for diagnosis of pulmonary tuberculosis in young children using multiple readers. [Thesis]. University of Cape Town; 2015. Available from: http://hdl.handle.net/11427/16594
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Missouri – Columbia
12.
Caldwell, Charles W. Jr.
Peptide nanoconjugates for tissue diagnostics and molecular imaging.
Degree: 2016, University of Missouri – Columbia
URL: http://hdl.handle.net/10355/62515
► The rise of targeted therapy in cancer treatment has created a strong need for characterization of a patient's tumor before receiving treatment. Many effective cancer…
(more)
▼ The rise of targeted therapy in cancer treatment has created a strong need for characterization of a patient's tumor before receiving treatment. Many effective cancer drugs are now being targeted to specific proteins present in the tumor, thus only patients who have tumors that express these proteins in appreciable amounts will respond to these kinds of therapy. The most popular method of diagnosing patients is through the practice of immunohistochemistry (IHC), where biopsied patient tissue is subjected to testing for specific protein expression. IHC works by incubating a primary antibody towards the target protein, followed by detection with a secondary antibody containing a reactive enzyme - most commonly, horseradish peroxidase (HRP). IHC procedures are expensive, comprises several steps, involves varying amounts of amplification due to enzyme reactivity, and is only as specific as the primary antibody. Patients receiving treatment using popular drugs targeted at common proteins such as EGFR, c-MET, and PD-L1 have shown varying degrees of responses based on initial IHC diagnosis, even when using FDA-approved
diagnostic kits. Due to the discrepancies seen between diagnosis and drug efficacy, we have developed new methods utilizing gold nanoparticles that utilize peptides to target protein biomarkers in human tissues. Peptides which are targeted towards receptors contain only the amino acid sequences which are sufficient for protein binding. Due to their tailored specificity, low cost, scalable production, and ease of modification, peptides can be an attractive method of investigating protein content in human tissues. We investigated the use of peptides combined with imaging agents as
diagnostic methods to compare with standard immunohistochemistry procedures. Gold nanorods (GNR) scatter light efficiently in the dark field, and their high surface-area-to-volume ratio allows each nanorod to be coated with many targeting peptides, enhancing specificity of each nanoparticle for the receptor of interest. We first investigated attachment of peptides to GNR that can be used to diagnose common biomarkers EGFR and cMET in tumor tissues. EGFR is one of the most commonly overexpressed proteins in human cancers, and many EGFR-targeted drugs have shown improvement of progression-free survival in patients. During the course of EGFR-targeted treatment it is common that a patient will eventually develop resistance to the EGFR-targeted drugs. One such mechanism is the circumventing of EGFR pathway through upregulation of the c-MET protein on the tumor surface. Once EGFR is internalized and c-MET is the dominant pathway, patients will stop responding to EGFR-targeted drug and the tumor will continue proliferation. There are numerous c-MET drugs on the market for second or third line therapy when resistance occurs with this mechanism, however diagnosis of the c-MET biomarker has become controversial due to poor
diagnostic results using the current standard IHC methods. We thus followed up our EGFR
diagnostic study by investigating…
Advisors/Committee Members: Kannan, Raghuraman (advisor).
Subjects/Keywords: Diagnostic immunohistochemistry
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Caldwell, C. W. J. (2016). Peptide nanoconjugates for tissue diagnostics and molecular imaging. (Thesis). University of Missouri – Columbia. Retrieved from http://hdl.handle.net/10355/62515
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Caldwell, Charles W Jr. “Peptide nanoconjugates for tissue diagnostics and molecular imaging.” 2016. Thesis, University of Missouri – Columbia. Accessed February 27, 2021.
http://hdl.handle.net/10355/62515.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Caldwell, Charles W Jr. “Peptide nanoconjugates for tissue diagnostics and molecular imaging.” 2016. Web. 27 Feb 2021.
Vancouver:
Caldwell CWJ. Peptide nanoconjugates for tissue diagnostics and molecular imaging. [Internet] [Thesis]. University of Missouri – Columbia; 2016. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/10355/62515.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Caldwell CWJ. Peptide nanoconjugates for tissue diagnostics and molecular imaging. [Thesis]. University of Missouri – Columbia; 2016. Available from: http://hdl.handle.net/10355/62515
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Cape Town
13.
Nair, Tamiya.
The risks of medical imaging: a survey of doctors' knowledge and consenting practice.
Degree: MMed, Division of Radiology, 2018, University of Cape Town
URL: http://hdl.handle.net/11427/29708
► Background: Diagnostic imaging forms an integral part of patient evaluation and its use has increased dramatically. Not only is medical imaging a source of increased…
(more)
▼ Background:
Diagnostic imaging forms an integral part of patient evaluation and its use has increased dramatically. Not only is medical imaging a source of increased radiation dose, but also poses other risks such as those related to the procedure performed, the contrast and drugs administered, acoustic and heat deposition and para-magnetic risks. While many studies have assessed doctors' knowledge of radiation risk, data regarding doctors' knowledge of the remaining risks of medical imaging and doctors' attitudes toward consenting practice for imaging is lacking. Aim: To survey and compare the levels of knowledge between referring clinicians and radiologists regarding the risks to patients undergoing medical imaging and to explore doctors' attitudes toward consenting practice. Method: A cross sectional, observational, descriptive study design was employed. The study was conducted using a non-validated, piloted, self-administered three-page questionnaire. The questionnaire was distributed to doctors in various stages of their medical careers at a tertiary level hospital. The questionnaire was constructed in sections including demographics, risks of medical imaging and consent practice. The maximum score potentially attainable was 79, with a point given for each correct answer. No points were given for incorrect, unsure or blank responses. Results: A total of 431 questionnaires were distributed but only 85 doctors (19 radiologists and 66 clinicians) returned a completed survey, yielding a response rate of 19,7%. Older respondents with more years of experience had greater levels of knowledge regarding the risks of medical imaging. There were no significant differences according to gender or university. Although the levels of knowledge of risk was poor overall, radiologists had greater levels of knowledge (mean knowledge score expressed as a percentage =79% compared to that of clinicians= 71%). The largest proportion of doctors' (49%) were of the opinion that clinicians should be responsible for obtaining consent for medical imaging. Only 18% of doctors (radiologists and clinicians) and 5% of clinicians admitted to feeling adequately prepared to obtain consent for medical imaging. Conclusion: We successfully surveyed and compared the levels of knowledge of medical imaging risks amongst doctors and determined their attitudes toward responsibility for consent. The levels of knowledge of the risks of medical imaging is inadequate among radiologists and poor amongst non-radiologists. While statutory body guidelines recommend that the performing health care provider obtain consent, there remains varying opinion as to who should obtain consent. The largest proportion of doctors' were of the opinion that clinicians should obtain consent for medical imaging - this despite clinicians' feelings of inadequacy when consenting patients to the risks of imaging. It is therefore important to take into consideration the levels of knowledge and comfort when making decisions as to who is best suited to obtain consent for medical imaging.…
Advisors/Committee Members: Andronikou, Savvas (advisor).
Subjects/Keywords: Diagnostic Radiology
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Nair, T. (2018). The risks of medical imaging: a survey of doctors' knowledge and consenting practice. (Thesis). University of Cape Town. Retrieved from http://hdl.handle.net/11427/29708
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Nair, Tamiya. “The risks of medical imaging: a survey of doctors' knowledge and consenting practice.” 2018. Thesis, University of Cape Town. Accessed February 27, 2021.
http://hdl.handle.net/11427/29708.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Nair, Tamiya. “The risks of medical imaging: a survey of doctors' knowledge and consenting practice.” 2018. Web. 27 Feb 2021.
Vancouver:
Nair T. The risks of medical imaging: a survey of doctors' knowledge and consenting practice. [Internet] [Thesis]. University of Cape Town; 2018. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/11427/29708.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Nair T. The risks of medical imaging: a survey of doctors' knowledge and consenting practice. [Thesis]. University of Cape Town; 2018. Available from: http://hdl.handle.net/11427/29708
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Cape Town
14.
Scholtz, Paul Victor John.
A retrospective study of CT angiography versus digital subtraction angiography in penetrating neck trauma.
Degree: Image, Division of Radiology, 2013, University of Cape Town
URL: http://hdl.handle.net/11427/2851
► BACKGROUND. Penetrating neck trauma is commonly encountered in South African trauma units, and is associated with high mortality and morbidity rates. The imaging protocol for…
(more)
▼ BACKGROUND. Penetrating neck trauma is commonly encountered in South African trauma units, and is associated with high mortality and morbidity rates. The imaging protocol for stable patients with penetrating neck trauma remains controversial. There is only sparse data validating the use of Computed Tomography Angiography (CTA) in the evaluation of penetrating neck trauma. OBJECTIVES. To assess the sensitivity and specificity of CTA versus Digital Subtraction Angiography (DSA) in detecting arterial injury and secondarily evaluate the ability of CT to assess non-arterial injury.
Advisors/Committee Members: Candy, S (advisor), Beningfield, S (advisor).
Subjects/Keywords: Diagnostic Radiology
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Scholtz, P. V. J. (2013). A retrospective study of CT angiography versus digital subtraction angiography in penetrating neck trauma. (Thesis). University of Cape Town. Retrieved from http://hdl.handle.net/11427/2851
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Scholtz, Paul Victor John. “A retrospective study of CT angiography versus digital subtraction angiography in penetrating neck trauma.” 2013. Thesis, University of Cape Town. Accessed February 27, 2021.
http://hdl.handle.net/11427/2851.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Scholtz, Paul Victor John. “A retrospective study of CT angiography versus digital subtraction angiography in penetrating neck trauma.” 2013. Web. 27 Feb 2021.
Vancouver:
Scholtz PVJ. A retrospective study of CT angiography versus digital subtraction angiography in penetrating neck trauma. [Internet] [Thesis]. University of Cape Town; 2013. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/11427/2851.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Scholtz PVJ. A retrospective study of CT angiography versus digital subtraction angiography in penetrating neck trauma. [Thesis]. University of Cape Town; 2013. Available from: http://hdl.handle.net/11427/2851
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Rutgers University
15.
Patel, Khushbu Dipak.
Assessment of optical transmission and image contrast at infrared wavelengths using tissue simulating phantoms and biological tissues.
Degree: MS, Biomedical Engineering, 2017, Rutgers University
URL: https://rucore.libraries.rutgers.edu/rutgers-lib/55614/
► In vivo fluorescence imaging is an emerging technique with potential for usage in non-invasive cancer screening, surveillance, real-time surgical guidance, and staging. Fluorescence imaging uses…
(more)
▼ In vivo fluorescence imaging is an emerging technique with potential for usage in non-invasive cancer screening, surveillance, real-time surgical guidance, and staging. Fluorescence imaging uses the interaction of non-ionizing optical radiation with endogenous fluorophores or fluorescent labels to provide real-time wide-field images of tissue structure and/or functional components. When imaging in vivo, excitation light must travel through overlying tissue to reach the fluorescent target and emitted fluorescence must then propagate back through the overlying tissue in order to be imaged onto a camera. Recently, fluorescent contrast agents have been developed with excitation and emission wavelengths in the near infrared (NIR) spectrum (~700 – 1,000 nm) in order to minimize attenuation and maximize the measured signal from tissue. While several clinical trials have shown the potential benefits of NIR contrast agents over visible fluorophores, there may still be room for improvement by moving to even longer wavelengths. As scattering is reduced as wavelength increases, some researchers are investigating fluorophores that emit in the short-wave infrared (SWIR) wavelength region (~1,000 – 2,300 nm). This study focuses on examining optical transmission and image contrast at NIR wavelengths and SWIR wavelengths to determine which wavelength region may be optimal for development of fluorescent contrast agents. Transmission and contrast measurements were performed on both tissue simulating phantoms and real biological tissues using 780 nm, 980 nm, and 1550 nm wavelengths. From the experiments conducted, it appears that fluorophore emissions should be chosen based on the goals of the specific application. For an application that requires simple detection of signal, near infrared wavelengths will be better as they can be detected with higher signal levels. For an application that focuses on imaging fluorophore-labeled tissues, short-wave infrared wavelengths will be the better option as they provided better image contrast
Advisors/Committee Members: Pierce, Mark C. (chair), School of Graduate Studies.
Subjects/Keywords: Diagnostic imaging
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Patel, K. D. (2017). Assessment of optical transmission and image contrast at infrared wavelengths using tissue simulating phantoms and biological tissues. (Masters Thesis). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/55614/
Chicago Manual of Style (16th Edition):
Patel, Khushbu Dipak. “Assessment of optical transmission and image contrast at infrared wavelengths using tissue simulating phantoms and biological tissues.” 2017. Masters Thesis, Rutgers University. Accessed February 27, 2021.
https://rucore.libraries.rutgers.edu/rutgers-lib/55614/.
MLA Handbook (7th Edition):
Patel, Khushbu Dipak. “Assessment of optical transmission and image contrast at infrared wavelengths using tissue simulating phantoms and biological tissues.” 2017. Web. 27 Feb 2021.
Vancouver:
Patel KD. Assessment of optical transmission and image contrast at infrared wavelengths using tissue simulating phantoms and biological tissues. [Internet] [Masters thesis]. Rutgers University; 2017. [cited 2021 Feb 27].
Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/55614/.
Council of Science Editors:
Patel KD. Assessment of optical transmission and image contrast at infrared wavelengths using tissue simulating phantoms and biological tissues. [Masters Thesis]. Rutgers University; 2017. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/55614/
Iowa State University
16.
Forseth, Anna.
Evaluation of diagnostic tools for naturally occurring lameness in swine.
Degree: 2020, Iowa State University
URL: https://lib.dr.iastate.edu/etd/17993
► Sow lameness is a production disease affecting not only animal welfare but also swine profitability. Second to reproductive problems, lameness is a major cause for…
(more)
▼ Sow lameness is a production disease affecting not only animal welfare but also swine profitability. Second to reproductive problems, lameness is a major cause for premature sow culling in the swine industry (Anil et al., 2005). It has been estimated that 32% of sows culled for lameness have only produced one litter (Boyle et al., 1998). Lameness has been estimated to cost the United States swine industry approximately $23 million/year (Butters-Johnson et al, 2011).
The overall goal of this thesis was to validate diagnostic tools using a naturally occurring sow lameness model. This work was completed through four objectives: 1) to determine if behavior assessments, mechanical nociceptive threshold testing and walking and standing lameness scoring could identify a lame sow, 2) to determine if behavior assessments, mechanical nociceptive threshold testing and walking and standing lameness scoring were affected by the body system suspected to be contributing to the lameness identified using the Swine Lameness Diagnostic Manual, 3) to determine lameness etiology within the suspected body system as guided by the Lameness Diagnostic Manual, 4) to evaluate the accuracy of the suspected lameness etiology using the results of the Swine Lameness Diagnostic Manual, standing lameness scoring, locomotion lameness scoring and swine veterinarian expertise.
The results of this thesis identified that the walking and standing lameness scoring systems and behavior are promising tools for a producer to use on farm for lame sow identification. However, behavior assessments, mechanical nociceptive threshold testing and walking and standing lameness scoring were less correlative when evaluating the body system suspected to influence lameness. The Swine Lameness Diagnostic Manual was able to identify a presumptive lameness etiology for each case. However, a panel of practicing swine veterinarians unanimously agreed that the manual identified the correct and complete lameness etiology on only 4.3% of the cases after reviewing all data and diagnostic testing for each case.
Subjects/Keywords: diagnostic; diagnostic manual; education; hoof; lameness; swine
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Forseth, A. (2020). Evaluation of diagnostic tools for naturally occurring lameness in swine. (Thesis). Iowa State University. Retrieved from https://lib.dr.iastate.edu/etd/17993
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Forseth, Anna. “Evaluation of diagnostic tools for naturally occurring lameness in swine.” 2020. Thesis, Iowa State University. Accessed February 27, 2021.
https://lib.dr.iastate.edu/etd/17993.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Forseth, Anna. “Evaluation of diagnostic tools for naturally occurring lameness in swine.” 2020. Web. 27 Feb 2021.
Vancouver:
Forseth A. Evaluation of diagnostic tools for naturally occurring lameness in swine. [Internet] [Thesis]. Iowa State University; 2020. [cited 2021 Feb 27].
Available from: https://lib.dr.iastate.edu/etd/17993.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Forseth A. Evaluation of diagnostic tools for naturally occurring lameness in swine. [Thesis]. Iowa State University; 2020. Available from: https://lib.dr.iastate.edu/etd/17993
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
17.
Baudrillart, Benoit.
Etude du procédé de croissance de films de diamant nanocristallin par dépôt chimique en phase vapeur assisté par plasma micro-onde distribué, à basse température et basse pression : Study of nanocrystalline diamond film growth process by distributed antenna array microwave plasma assisted chemical vapor deposition, at low temperature and low pressure.
Degree: Docteur es, Genies des procédés, 2017, Sorbonne Paris Cité
URL: http://www.theses.fr/2017USPCD051
► Ce travail de thèse porte sur la compréhension et le contrôle du procédé de croissance de films de diamant nanocristallin (DNC) par dépôt chimique en…
(more)
▼ Ce travail de thèse porte sur la compréhension et le contrôle du procédé de croissance de films de diamant nanocristallin (DNC) par dépôt chimique en phase vapeur assisté par plasma micro-onde distribué. Deux axes de travail ont été suivis pour atteindre ces objectifs : une étude « matériau » visant à étudier les mécanismes de germination et de croissance et les caractéristiques des films de DNC élaborés ; une étude « plasma » s’intéressant au diagnostic des décharges basse pression H₂ /CH₄/CO₂ utilisées pour la croissance.Concernant le premier volet, des techniques de caractérisation ex situ, telles que la microscopie électronique à balayage, à transmission haute résolution et à force atomique, la spectroscopie Raman, la diffraction des rayons X, la réflectométrie UV-visible, et in situ, telles que l’interférométrie de réflectance laser, ont été mises en oeuvre pour étudier la densité de germination, la morphologie, la topographie, la microstructure, la pureté et la vitesse de croissance des films de DNC. L’influence de certains paramètres du procédé, tels que la pression dans l’enceinte, la position du substrat, la composition gazeuse, la température de surface, la puissance micro-onde et le prétraitement ex situ du substrat, a été étudié pour le silicium. La synthèse de DNC jusqu’à une température aussi basse que 130 °C a ainsi pu être maîtrisée. La faisabilité de la croissance à cette température sur un matériau polymère comme le polytétrafluoroéthylène (PTFE) a été démontrée. La croissance de films de DNC sur d’autres types de substrats tels que le nitrure de silicium et l'acier inoxydable a également été examinée. Concernant la deuxième partie de ce travail, le diagnostic du plasma de dépôt a été effectué par spectroscopie optique d’émission et spectroscopie d'absorption infrarouge en utilisant comme sources de rayonnement des diodes lasers accordables en longueurs d’ondes et des lasers à cascade quantique à cavité externe. L’influence des conditions expérimentales, en particulier de la puissance micro-onde et de la pression dans l’enceinte, sur la concentration du radical méthyl CH₃, précurseur de croissance du diamant, et de cinq molécules stables (CH₄, CO₂, CO, C₂H₂, C₂H₆), ainsi que sur le degré de dissociation de H₂ et les températures cinétiques, vibrationnelles et rotationnelles des espèces, a été étudiée. Le degré de dissociation élevé des précurseurs gazeux, pour une température de gaz relativement faible de quelques centaines de kelvins, indiquent que la chimie du plasma est principalement gouvernée par des processus électroniques. Le système à plasma micro-onde distribué utilisé permet cependant de produire certaines espèces de croissance et de gravure en quantité comparable aux procédés de croissance de DNC conventionnels tout en permettant le processus de synthèse à basse température.
This PhD thesis focuses on the understanding and the control of the nanocrystalline diamond (NCD) film growth process by distributed antenna array microwave plasma-assisted chemical vapor deposition. Two approaches…
Advisors/Committee Members: Achard, Jocelyn (thesis director), Bénédic, Fabien (thesis director).
Subjects/Keywords: Diagnostic in situ; In situ diagnostic
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Baudrillart, B. (2017). Etude du procédé de croissance de films de diamant nanocristallin par dépôt chimique en phase vapeur assisté par plasma micro-onde distribué, à basse température et basse pression : Study of nanocrystalline diamond film growth process by distributed antenna array microwave plasma assisted chemical vapor deposition, at low temperature and low pressure. (Doctoral Dissertation). Sorbonne Paris Cité. Retrieved from http://www.theses.fr/2017USPCD051
Chicago Manual of Style (16th Edition):
Baudrillart, Benoit. “Etude du procédé de croissance de films de diamant nanocristallin par dépôt chimique en phase vapeur assisté par plasma micro-onde distribué, à basse température et basse pression : Study of nanocrystalline diamond film growth process by distributed antenna array microwave plasma assisted chemical vapor deposition, at low temperature and low pressure.” 2017. Doctoral Dissertation, Sorbonne Paris Cité. Accessed February 27, 2021.
http://www.theses.fr/2017USPCD051.
MLA Handbook (7th Edition):
Baudrillart, Benoit. “Etude du procédé de croissance de films de diamant nanocristallin par dépôt chimique en phase vapeur assisté par plasma micro-onde distribué, à basse température et basse pression : Study of nanocrystalline diamond film growth process by distributed antenna array microwave plasma assisted chemical vapor deposition, at low temperature and low pressure.” 2017. Web. 27 Feb 2021.
Vancouver:
Baudrillart B. Etude du procédé de croissance de films de diamant nanocristallin par dépôt chimique en phase vapeur assisté par plasma micro-onde distribué, à basse température et basse pression : Study of nanocrystalline diamond film growth process by distributed antenna array microwave plasma assisted chemical vapor deposition, at low temperature and low pressure. [Internet] [Doctoral dissertation]. Sorbonne Paris Cité; 2017. [cited 2021 Feb 27].
Available from: http://www.theses.fr/2017USPCD051.
Council of Science Editors:
Baudrillart B. Etude du procédé de croissance de films de diamant nanocristallin par dépôt chimique en phase vapeur assisté par plasma micro-onde distribué, à basse température et basse pression : Study of nanocrystalline diamond film growth process by distributed antenna array microwave plasma assisted chemical vapor deposition, at low temperature and low pressure. [Doctoral Dissertation]. Sorbonne Paris Cité; 2017. Available from: http://www.theses.fr/2017USPCD051
18.
Hotait, Hassane.
Contribution au processus de surveillance intelligente des machines tournantes : cas des roulements à billes. : Contribution to the process of smart monitoring of rotating machines : the case of ball bearings.
Degree: Docteur es, Matériaux, mécanique, structures, 2020, Reims
URL: http://www.theses.fr/2020REIMS019
► La production industrielle est actuellement déterminée par la concurrence mondiale et la nécessité d’adapter rapidement la production aux demandes du marché en évolution constante. Ces…
(more)
▼ La production industrielle est actuellement déterminée par la concurrence mondiale et la nécessité d’adapter rapidement la production aux demandes du marché en évolution constante. Ces exigences ne peuvent être satisfaites que par des avancées radicales dans les technologies de fabrication actuelles. L’industrie 4.0 est une approche intéressante basée sur l’intégration des processus d’entreprise et de fabrication. L’objectif de cette thèse est de développer une méthodologie de la maintenance 4.0 pour briser les compromis des anciennes stratégies en permettant aux entreprises de maximiser la vie utile de leurs équipements de production tout en évitant les temps d’arrêt imprévus, par combinaison de l’analyse vibratoire et la méthode de reconnaissance de formes pour détecter, et suivre la dégradation d’un défaut. Deux méthodologies sont proposées, IRT-OPTICS (Improved Real-Time Ordering Points to Identify the Clustering Structure) et AOC-OPTICS (Automatic Online Classification monitoring based on OPTICS), basées sur la méthode de reconnaissance de formes non supervisée. Ces méthodes devraient aboutir à une surveillance autonome. Elles visent à déceler les dysfonctionnements des machines tournantes et de suivre l’évolution de ce dysfonctionnement. Cette démarche commence par l’extraction de trois types d’indicateurs (scalaires, temps-fréquence, temps-échelle), suivie par une réduction de dimension dans un espace visuel, représentant la présence de défauts dans le roulement. L’étape suivante consiste à suivre l’évolution de la dégradation en utilisant cinq paramètres : Davies-Bouldin index, Calinski-index, le saut du centre de la classe, la densité, le contour.
Industrial production is currently determined by global competition and the need to adapt the production quickly to changing market demands. These requirements can only be met by radical advancements in the current manufacturing technologies. Industry 4.0 is an interesting approach based on the integration of business and manufacturing processes. The objective of this thesis is to develop a methodology of maintenance 4.0 to break the trade-offs of old strategies by allowing companies to maximize the useful life of their production equipment while avoiding unplanned downtime, by combining vibration analysis and pattern recognition methods to detect and track the degradation of a defect. Two methodologies proposed IRT-OPTICS (Improved Real-Time Ordering Points To Identify the Clustering Structure) and AOC-OPTICS (Automatic Online Classification monitoring based on OPTICS), based on the unsupervised pattern recognition method. These methods should lead to autonomous surveillance. They aim to detect the malfunctions of rotating machines and to monitor the evolution of this malfunction. This starts with the extraction of three types of indicators (scalar, time-frequency, time-scale), followed by a dimensional reduction in a visual space, representing the presence of defects in the bearing. The next step is to follow the evolution of the degradation using five…
Advisors/Committee Members: Chiementin, Xavier (thesis director), Rasolofondraibe, Lanto (thesis director).
Subjects/Keywords: Classification; Surveillance; Diagnostic; Clustering; Surveillance; Diagnostic; 621.3
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Hotait, H. (2020). Contribution au processus de surveillance intelligente des machines tournantes : cas des roulements à billes. : Contribution to the process of smart monitoring of rotating machines : the case of ball bearings. (Doctoral Dissertation). Reims. Retrieved from http://www.theses.fr/2020REIMS019
Chicago Manual of Style (16th Edition):
Hotait, Hassane. “Contribution au processus de surveillance intelligente des machines tournantes : cas des roulements à billes. : Contribution to the process of smart monitoring of rotating machines : the case of ball bearings.” 2020. Doctoral Dissertation, Reims. Accessed February 27, 2021.
http://www.theses.fr/2020REIMS019.
MLA Handbook (7th Edition):
Hotait, Hassane. “Contribution au processus de surveillance intelligente des machines tournantes : cas des roulements à billes. : Contribution to the process of smart monitoring of rotating machines : the case of ball bearings.” 2020. Web. 27 Feb 2021.
Vancouver:
Hotait H. Contribution au processus de surveillance intelligente des machines tournantes : cas des roulements à billes. : Contribution to the process of smart monitoring of rotating machines : the case of ball bearings. [Internet] [Doctoral dissertation]. Reims; 2020. [cited 2021 Feb 27].
Available from: http://www.theses.fr/2020REIMS019.
Council of Science Editors:
Hotait H. Contribution au processus de surveillance intelligente des machines tournantes : cas des roulements à billes. : Contribution to the process of smart monitoring of rotating machines : the case of ball bearings. [Doctoral Dissertation]. Reims; 2020. Available from: http://www.theses.fr/2020REIMS019
Tulane University
19.
Beddingfield, Brandon.
Design and Evaluation of a Non-Structural Protein 1-Based Diagnostic Zika Virus Infection.
Degree: 2020, Tulane University
URL: https://digitallibrary.tulane.edu/islandora/object/tulane:120381
► [email protected]
Zika virus (ZIKV), a member of the Flaviviridae family, was the cause of a large viral outbreak reaching across the Americas during 2015 and…
(more)
▼ [email protected]
Zika virus (ZIKV), a member of the Flaviviridae family, was the cause of a large
viral outbreak reaching across the Americas during 2015 and 2016. Discovered in 1947,
it has historically been a neglected disease, due to its emergence in humans on a large
scale being recent. At the time of the outbreak, no FDA approved ZIKV diagnostics
existed, and those that were able to detect the virus were unable to distinguish it from
related viruses such as Dengue virus (DENV), and at this time, no approved therapeutics
or vaccines are available. We investigated the ability of diagnostics targeted toward both
anti-NS1 antibodies and NS1 antigen circulating during infection to detect current or past
ZIKV disease, as well as the capability of NS1 to produce a protective response. Our
studies suggest anti-NS1diagnostics are feasible, though some populations may display
an immune response reminiscent of a prior infection. Levels of circulating NS1 were
lower than those produced during DENV infection, though were still detectable with our
assay. Additionally, intraperitoneal immunization with NS1 produced an anti-ZIKV NS1
response that coincided with a decrease in viremia, though further work was needed to
discern life-prolonging effects. Together, this work furthers the development of the tools
necessary to combat future outbreaks of ZIKV in vulnerable populations.
1
Brandon Beddingfield
Advisors/Committee Members: Garry, Robert (Thesis advisor), School of Medicine Microbiology and Immunology (Degree granting institution).
Subjects/Keywords: Diagnostic; Zika; Flavivirus
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Beddingfield, B. (2020). Design and Evaluation of a Non-Structural Protein 1-Based Diagnostic Zika Virus Infection. (Thesis). Tulane University. Retrieved from https://digitallibrary.tulane.edu/islandora/object/tulane:120381
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Beddingfield, Brandon. “Design and Evaluation of a Non-Structural Protein 1-Based Diagnostic Zika Virus Infection.” 2020. Thesis, Tulane University. Accessed February 27, 2021.
https://digitallibrary.tulane.edu/islandora/object/tulane:120381.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Beddingfield, Brandon. “Design and Evaluation of a Non-Structural Protein 1-Based Diagnostic Zika Virus Infection.” 2020. Web. 27 Feb 2021.
Vancouver:
Beddingfield B. Design and Evaluation of a Non-Structural Protein 1-Based Diagnostic Zika Virus Infection. [Internet] [Thesis]. Tulane University; 2020. [cited 2021 Feb 27].
Available from: https://digitallibrary.tulane.edu/islandora/object/tulane:120381.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Beddingfield B. Design and Evaluation of a Non-Structural Protein 1-Based Diagnostic Zika Virus Infection. [Thesis]. Tulane University; 2020. Available from: https://digitallibrary.tulane.edu/islandora/object/tulane:120381
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Nairobi
20.
Terah, Stephen A A.
Herbalist Diagnostic Support System: A Prototype
.
Degree: 2009, University of Nairobi
URL: http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/23652
► The Herbalist Diagnostic Support System has been built using expert system techniques. Expert Systems are useful in capturing rare knowledge from a human expert into…
(more)
▼ The Herbalist Diagnostic Support System has been built using expert system techniques.
Expert Systems are useful in capturing rare knowledge from a human expert into a
computer system, thereby allowing a non-expert to be able to use the knowledge captured
intothe computer to solve problems from the associated problem domain. The knowledge
acquisition bottleneck is a fundamental problem in building expert systems. This work
gives a report on how a Herbalist Diagnostic Support System has been built in spite of the
knowledge acquisition bottleneck. In this report a framework where the knowledge based
system approach is applied to assist attend to patients in a herbalists setting has also been
formulated. The resulting prototype that was designed was evaluated by doctors,
herbalists and system analysts, and found to be acceptable. They also found the system
interface acceptable.
Subjects/Keywords: Diagnostic Support System
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Terah, S. A. A. (2009). Herbalist Diagnostic Support System: A Prototype
. (Thesis). University of Nairobi. Retrieved from http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/23652
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Terah, Stephen A A. “Herbalist Diagnostic Support System: A Prototype
.” 2009. Thesis, University of Nairobi. Accessed February 27, 2021.
http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/23652.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Terah, Stephen A A. “Herbalist Diagnostic Support System: A Prototype
.” 2009. Web. 27 Feb 2021.
Vancouver:
Terah SAA. Herbalist Diagnostic Support System: A Prototype
. [Internet] [Thesis]. University of Nairobi; 2009. [cited 2021 Feb 27].
Available from: http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/23652.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Terah SAA. Herbalist Diagnostic Support System: A Prototype
. [Thesis]. University of Nairobi; 2009. Available from: http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/23652
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
21.
Touati, Youcef.
Diagnostic robuste et estimation de défauts à base de modèle Bond Graph : Robust diagnosis and fault estimation using bond graph approach.
Degree: Docteur es, Automatique et Informatique Industrielle, 2012, Université Lille I – Sciences et Technologies
URL: http://www.theses.fr/2012LIL10100
► Ce travail de thèse concerne la conception d’un système de diagnostic robuste à base de modèle bond graph et a pour objectif principal de générer…
(more)
▼ Ce travail de thèse concerne la conception d’un système de diagnostic robuste à base de modèle bond graph et a pour objectif principal de générer des seuils robustes aux incertitudes de mesures mais aussi la génération systématiques des équations d’estimation de défauts. Une procédure de génération des seuils basée sur une représentation graphiques des incertitudes de mesure a été développée et implémentée sur un système réel. La représentation bond graph sous forme LFT (transformation linéaire fractionnelle) a été exploitée pour la génération des équations d’estimation de défauts qui sont utilisées pour l’amélioration de la décision concernant l’isolabilité de défauts ayant la même signature de pannes ainsi à l’analyse de la sensibilité des résidus aux défauts capteurs, actionneurs et aux défauts liés aux paramètres. Les algorithmes développés dans ce travail de thèse ont été validés par une implémentation sur un système mécatronique représentant un robot mobile, appelé : Robotino.
This work deals with robust bond graph model-based fault diagnosis. The main objectives of this work are related to the generation of robust thresholds with respect to measurement uncertainties, and the creation of a systematic procedure for the generation of fault estimation equations. A procedure of thresholds generation based on a graphical representation of the measurement uncertainty has been developed and implemented on a real system. The Bond graph under LFT (linear fractional transformation) form has been used for the generation of fault estimation equations. These equations are used to improve the decision step concerning the isolation of the faults having the same signature and for analyzing the sensitivity of the residuals to faults affecting sensors, actuators and parameters. The algorithms developed in this work have been on a mechatronic system representing a mobile robot, called: Robotino.
Advisors/Committee Members: Ould Bouamama, Belkacem (thesis director), Merzouki, Rochdi (thesis director).
Subjects/Keywords: Diagnostic robuste; 629.895
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Touati, Y. (2012). Diagnostic robuste et estimation de défauts à base de modèle Bond Graph : Robust diagnosis and fault estimation using bond graph approach. (Doctoral Dissertation). Université Lille I – Sciences et Technologies. Retrieved from http://www.theses.fr/2012LIL10100
Chicago Manual of Style (16th Edition):
Touati, Youcef. “Diagnostic robuste et estimation de défauts à base de modèle Bond Graph : Robust diagnosis and fault estimation using bond graph approach.” 2012. Doctoral Dissertation, Université Lille I – Sciences et Technologies. Accessed February 27, 2021.
http://www.theses.fr/2012LIL10100.
MLA Handbook (7th Edition):
Touati, Youcef. “Diagnostic robuste et estimation de défauts à base de modèle Bond Graph : Robust diagnosis and fault estimation using bond graph approach.” 2012. Web. 27 Feb 2021.
Vancouver:
Touati Y. Diagnostic robuste et estimation de défauts à base de modèle Bond Graph : Robust diagnosis and fault estimation using bond graph approach. [Internet] [Doctoral dissertation]. Université Lille I – Sciences et Technologies; 2012. [cited 2021 Feb 27].
Available from: http://www.theses.fr/2012LIL10100.
Council of Science Editors:
Touati Y. Diagnostic robuste et estimation de défauts à base de modèle Bond Graph : Robust diagnosis and fault estimation using bond graph approach. [Doctoral Dissertation]. Université Lille I – Sciences et Technologies; 2012. Available from: http://www.theses.fr/2012LIL10100
22.
Bressel, Mathieu.
Modélisation raphique pour le pronostic robuste de pile à combustible à membrane échangeuse de proton : Graphical modeling for robust prognostic of proton exchange membrane fuel cell.
Degree: Docteur es, Automatique, Génie Informatique, Traitement du Signal et des Images, 2016, Université Lille I – Sciences et Technologies
URL: http://www.theses.fr/2016LIL10119
► La pile à combustible (PàC) est actuellement la solution alternative aux énergies fossiles la plus prometteuse. Il convient cependant d’améliorer sa fiabilité. Cela nécessite la…
(more)
▼ La pile à combustible (PàC) est actuellement la solution alternative aux énergies fossiles la plus prometteuse. Il convient cependant d’améliorer sa fiabilité. Cela nécessite la mise en place d’algorithmes capables d’estimer en temps réel l´état de santé de son fonctionnement et de prédire sa durée de vie résiduelle. Les méthodes de pronostic basées sur un modèle physique offrent des résultats précis car ne nécessitent ni apprentissage de modes de fonctionnement ni expertise de l’opérateur. Toutefois, la problématique pour un système PàC réside dans le couplage de plusieurs phénomènes physique, l’incertitude des paramètres du modèle et la faible instrumentation du cœur de pile. Ainsi, nous utilisons des modèles incertains basés sur l’outil Bond Graph bien adapté pour la PàC. Concrètement, les incertitudes sont intégrées au modèle d´évolution des puissances qui est utilisé pour la détection du vieillissement et l’estimation de la dégradation de la PàC. Un modèle de dégradation est utilisé par un filtre de Kalman étendu pour l’estimation de l’état de santé, de la dynamique du vieillissement et permet de quantifier l’incertitude pour toute condition opératoire. Un algorithme Inverse First Order Reliability Method permet ensuite la prédiction de la durée de vie résiduelle et de l’incertitude de prédiction inhérente. La méthode globale a été validée sur différents jeux de données expérimentales. Grâce à l’ensemble de ces outils, un contrôle par inversion de modèle REM (Représentation Energétique Macroscopique) à paramètres variant, robuste au vieillissement a été développé en se basant sur l’estimation de l’état de santé.
The fuel cell (FC) is at present the alternative solution to the fossil fuels the most promising. It is however advisable to improve its reliability. This requires the implementation of algorithms capable of estimating in real time the state of health and forecasting its remaining useful life (prognostics). The methods of prognostics based on a physical model offer precise results once they do not requiring either learning or expertise of the operator. However, the problem for a FC system lies in the coupling of several physical phenomena, the uncertainty of the parameters of the model and the low instrumentation of the FC stack.Thus, we use uncertain models based on the Bond Graph tool well adapted for the FC. Concretely, the parameters uncertainties are integrated in the model of evolution of the powers which is used for the detection of the beginning of the aging and the estimation of the degradation of the FC based on the causal and structural properties of the model. The generated model of degradation is used by an extended Kalman filter which allows the estimation of the state of health , the dynamics of the aging and the quantification of the uncertainty for any operating condition (of temperature, current and pressure). An Inverse First Order Reliability Method is then used for the prediction of the remaining useful life and the inherent uncertainty. The global method was validated on various…
Advisors/Committee Members: Ould Bouamama, Belkacem (thesis director), Hissel, Daniel (thesis director), Hilairet, Mickaël (thesis director).
Subjects/Keywords: Diagnostic; Pronostic; 629.895
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Bressel, M. (2016). Modélisation raphique pour le pronostic robuste de pile à combustible à membrane échangeuse de proton : Graphical modeling for robust prognostic of proton exchange membrane fuel cell. (Doctoral Dissertation). Université Lille I – Sciences et Technologies. Retrieved from http://www.theses.fr/2016LIL10119
Chicago Manual of Style (16th Edition):
Bressel, Mathieu. “Modélisation raphique pour le pronostic robuste de pile à combustible à membrane échangeuse de proton : Graphical modeling for robust prognostic of proton exchange membrane fuel cell.” 2016. Doctoral Dissertation, Université Lille I – Sciences et Technologies. Accessed February 27, 2021.
http://www.theses.fr/2016LIL10119.
MLA Handbook (7th Edition):
Bressel, Mathieu. “Modélisation raphique pour le pronostic robuste de pile à combustible à membrane échangeuse de proton : Graphical modeling for robust prognostic of proton exchange membrane fuel cell.” 2016. Web. 27 Feb 2021.
Vancouver:
Bressel M. Modélisation raphique pour le pronostic robuste de pile à combustible à membrane échangeuse de proton : Graphical modeling for robust prognostic of proton exchange membrane fuel cell. [Internet] [Doctoral dissertation]. Université Lille I – Sciences et Technologies; 2016. [cited 2021 Feb 27].
Available from: http://www.theses.fr/2016LIL10119.
Council of Science Editors:
Bressel M. Modélisation raphique pour le pronostic robuste de pile à combustible à membrane échangeuse de proton : Graphical modeling for robust prognostic of proton exchange membrane fuel cell. [Doctoral Dissertation]. Université Lille I – Sciences et Technologies; 2016. Available from: http://www.theses.fr/2016LIL10119
Columbia University
23.
Monard, Francois.
Taming unstable inverse problems: Mathematical routes toward high-resolution medical imaging modalities.
Degree: 2012, Columbia University
URL: https://doi.org/10.7916/D8DZ0GDK
► This thesis explores two mathematical routes that make the transition from some severely ill-posed parameter reconstruction problems to better-posed versions of them. The general introduction…
(more)
▼ This thesis explores two mathematical routes that make the transition from some severely ill-posed parameter reconstruction problems to better-posed versions of them. The general introduction starts by defining what we mean by an inverse problem and its theoretical analysis. We then provide motivations that come from the field of medical imaging. The first part consists in the analysis of an inverse problem involving the Boltzmann transport equation, with applications in Optical Tomography. There we investigate the reconstruction of the spatially-dependent part of the scattering kernel, from knowledge of angularly averaged outgoing traces of transport solutions and isotropic boundary sources. We study this problem in the stationary regime first, then in the time-harmonic regime. In particular we show, using techniques from functional analysis and stationary phase, that this inverse problem is severely ill-posed in the former setting, whereas it is mildly ill-posed in the latter. In this case, we deduce that making the measurements depend on modulation frequency allows to improve the stability of reconstructions. In the second part, we investigate the inverse problem of reconstructing a tensor-valued conductivity (or diffusion) coefficient in a second-order elliptic partial differential equation, from knowledge of internal measurements of power density type. This problem finds applications in the medical imaging modalities of Electrical Impedance Tomography and Optical Tomography, and the fact that one considers power densities is justified in practice by assuming a coupling of this physical model with ultrasound waves, a coupling assumption that is characteristic of so-called hybrid medical imaging methods. Starting from the famous Calderon's problem (i.e. the same parameter reconstruction problem from knowledge of boundary fluxes of solutions), and recalling its lack of injectivity and severe instability, we show how going from Dirichlet-to-Neumann data to considering the power density operator leads to reconstruction of the full conductivity tensor via explicit inversion formulas. Moreover, such reconstruction algorithms only require the loss of either zero or one derivative from the power density functionals to the unknown, depending on what part of the tensor one wants to reconstruct. The inversion formulas are worked out with the help of linear algebra and differential geometry, in particular calculus with the Euclidean connection. The practical pay-off of such theoretical improvements in injectivity and stability is twofold: (i) the lack of injectivity of Calderà³n's problem, no longer existing when using power density measurements, implies that future medical imaging modalities such as hybrid methods may make anisotropic properties of human tissues more accessible; (ii) the improvements in stability for both problems in transport and conductivity may yield practical improvements in the resolution of images of the reconstructed coefficients.
Subjects/Keywords: Mathematics; Diagnostic imaging
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Monard, F. (2012). Taming unstable inverse problems: Mathematical routes toward high-resolution medical imaging modalities. (Doctoral Dissertation). Columbia University. Retrieved from https://doi.org/10.7916/D8DZ0GDK
Chicago Manual of Style (16th Edition):
Monard, Francois. “Taming unstable inverse problems: Mathematical routes toward high-resolution medical imaging modalities.” 2012. Doctoral Dissertation, Columbia University. Accessed February 27, 2021.
https://doi.org/10.7916/D8DZ0GDK.
MLA Handbook (7th Edition):
Monard, Francois. “Taming unstable inverse problems: Mathematical routes toward high-resolution medical imaging modalities.” 2012. Web. 27 Feb 2021.
Vancouver:
Monard F. Taming unstable inverse problems: Mathematical routes toward high-resolution medical imaging modalities. [Internet] [Doctoral dissertation]. Columbia University; 2012. [cited 2021 Feb 27].
Available from: https://doi.org/10.7916/D8DZ0GDK.
Council of Science Editors:
Monard F. Taming unstable inverse problems: Mathematical routes toward high-resolution medical imaging modalities. [Doctoral Dissertation]. Columbia University; 2012. Available from: https://doi.org/10.7916/D8DZ0GDK
University of Arizona
24.
Nelson, Rebecca.
Diagnostic Challenges: Advancing Assay Design
.
Degree: 2018, University of Arizona
URL: http://hdl.handle.net/10150/630106
► Prologue: A unique aspect of the Professional Science Masters Applied Bioscience program is to immerse future graduates into the fields of scientific research inclusive of…
(more)
▼ Prologue: A unique aspect of the Professional Science Masters Applied Bioscience program is to
immerse future graduates into the fields of scientific research inclusive of both business and
basic science. At the culmination of the program, an 8 credit hour internship requirement proved
to be an invaluable opportunity for me to experience a broad range of scientific inquiry.
Throughout the duration of the internship, I was able to learn and master laboratory techniques,
adhere to federal and state regulations, practice communicating my results, and ultimately be a
contributing member of a collaborative team. In return, I aided my supervisors by completing
projects and assigned tasks that was of great value and/or interest to the company. Internships
can be done at one company or split to be completed at two separate industries. I was fortunate
enough to be able to experience two companies, one focusing more on research and assay
development (MSDx) and the other focusing on
diagnostic tools to add to their testing services
(Pharos Dx). The first internship was with MSDx, Inc., a research company aiming to provide
diagnostic solutions for neurodegenerative disorders. The researchers were interested in moving
a first generation assay to a second generation assay for greater specificity in detecting tau, a
protein which is primarily located within the brain and a proven marker for brain degeneration
[10, 11]. Their first generation assay, an indirect ELISA, is compatible with their current anti-tau
monoclonal and polyclonal antibodies. My responsibilities were to search for additional anti-tau
antibodies that could be used as pairs in a sandwich assay and would detect an epitope within the
tau amino acid sequence of interest (c-terminus of the protein). At the conclusion of the
internship, I created a table of commercially available antibodies and provided it to the company
(table 1 within the paper). I was also able to demonstrate how the first generation assay worked
to model the first steps that would be taken when testing a new antibody for assay development
(figure 4). The second internship took place at Pharos Dx., which is a
diagnostic company utilizing
liquid-chromatography mass-spectrometry as part of their testing services. Pharos Dx was
looking to offer microsampling devices to their clientele as it would help veterinarians to easily
collect samples from animals. Microsampling has a disadvantage with the hematocrit where an
unknown volume of blood would affect the overall spreading and homogeneity of the sample
across the filter paper [43, 46]. My responsibility during this internship was to research the
various microsampling tools currently out on the market. With the amount of published papers
available, my objective was to sort through the validated and completed experiments to make a
recommendation to Pharos Dx regarding the microsampling device to pursue and explore further.
At the conclusion of the internship, I summarized my findings (presented within this paper) and
…
Advisors/Committee Members: Wertheimer, Anne (advisor).
Subjects/Keywords: diagnostic & laboratory science
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Nelson, R. (2018). Diagnostic Challenges: Advancing Assay Design
. (Masters Thesis). University of Arizona. Retrieved from http://hdl.handle.net/10150/630106
Chicago Manual of Style (16th Edition):
Nelson, Rebecca. “Diagnostic Challenges: Advancing Assay Design
.” 2018. Masters Thesis, University of Arizona. Accessed February 27, 2021.
http://hdl.handle.net/10150/630106.
MLA Handbook (7th Edition):
Nelson, Rebecca. “Diagnostic Challenges: Advancing Assay Design
.” 2018. Web. 27 Feb 2021.
Vancouver:
Nelson R. Diagnostic Challenges: Advancing Assay Design
. [Internet] [Masters thesis]. University of Arizona; 2018. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/10150/630106.
Council of Science Editors:
Nelson R. Diagnostic Challenges: Advancing Assay Design
. [Masters Thesis]. University of Arizona; 2018. Available from: http://hdl.handle.net/10150/630106
Columbia University
25.
Kruchevsky, Natalia.
The Role of Magnetic Resonance in Prostate Cancer Diagnosis, Characterization and Treatment.
Degree: 2013, Columbia University
URL: https://doi.org/10.7916/D8HQ3WV1
► One in six men will be affected by prostate cancer in their life time. Prostate cancer can be slow or fast growing and it affects…
(more)
▼ One in six men will be affected by prostate cancer in their life time. Prostate cancer can be slow or fast growing and it affects mainly men over fifty. Current options for treatments are surgery, radiation, hormone therapy, immunotherapy, chemotherapy and active surveillance. Magnetic resonance imaging and spectroscopy is a non-invasive, sensitive, and non-radioactive way to detect, characterize and understand the anatomy, physiology and metabolism of a tumor. MRI provides high image resolution that depicts the zonal anatomy of the prostate and cancer in areas that may have been missed by a biopsy. The field of MRI/MRS is constantly evolving toward new emerging techniques that can provide higher accuracy and sensitivity for cancer detection as well as treatment planning.
Subjects/Keywords: Diagnostic imaging; Oncology
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Kruchevsky, N. (2013). The Role of Magnetic Resonance in Prostate Cancer Diagnosis, Characterization and Treatment. (Masters Thesis). Columbia University. Retrieved from https://doi.org/10.7916/D8HQ3WV1
Chicago Manual of Style (16th Edition):
Kruchevsky, Natalia. “The Role of Magnetic Resonance in Prostate Cancer Diagnosis, Characterization and Treatment.” 2013. Masters Thesis, Columbia University. Accessed February 27, 2021.
https://doi.org/10.7916/D8HQ3WV1.
MLA Handbook (7th Edition):
Kruchevsky, Natalia. “The Role of Magnetic Resonance in Prostate Cancer Diagnosis, Characterization and Treatment.” 2013. Web. 27 Feb 2021.
Vancouver:
Kruchevsky N. The Role of Magnetic Resonance in Prostate Cancer Diagnosis, Characterization and Treatment. [Internet] [Masters thesis]. Columbia University; 2013. [cited 2021 Feb 27].
Available from: https://doi.org/10.7916/D8HQ3WV1.
Council of Science Editors:
Kruchevsky N. The Role of Magnetic Resonance in Prostate Cancer Diagnosis, Characterization and Treatment. [Masters Thesis]. Columbia University; 2013. Available from: https://doi.org/10.7916/D8HQ3WV1
University of Texas – Austin
26.
Jiang, Yu.
Nucleic acid circuit and its application in genetic diagnostic.
Degree: PhD, Chemistry, 2016, University of Texas – Austin
URL: http://hdl.handle.net/2152/39611
► DNA can execute programmed strand exchange reactions that process signals and information. In particular, toehold-mediated strand exchange, a process in which one strand of a…
(more)
▼ DNA can execute programmed strand exchange reactions that process signals and information. In particular, toehold-mediated strand exchange, a process in which one strand of a hemi-duplex is replaced by another, single strand to create a more stable complex, is the basis for many DNA circuits. By engineering several strand exchange reactions in a systematic way, complex DNA circuits can be created that accomplish sophisticated control tasks, similar to an electronic circuit. In this dissertation, we will demonstrate how we engineered and improved a toehold-mediated strand exchanged-based reaction, catalytic hairpin assembly (CHA), to make it into a real-world nucleic acid
diagnostic. While CHA has previously been shown to act as an excellent amplifier of nucleic acid signals, it can sometimes execute non-specifically even in the absence of catalyst, limiting signal-to-noise and limits of detection. By introducing two mismatched bases into a specific domain on the circuit, the background leakage can be greatly decreased and the signal-to-noise ratio can be improved from less than 10 to over 100. However, the improvement of the signal:background ratio still cannot increase sensitivity compatible to the enzyme-based nucleic acid amplification. Still, DNA circuits can improve upon background issues inherent in isothermal amplification reactions, which often produce spurious side products. We engineered DNA circuits that were thermostable from 37 °C to 60 °C and used these for the real-time detection of isothermal amplification reactions. These circuits in essence acted like an additional probe to measure the accumulation of correct, rather than spurious, amplicons. One isothermal amplification reaction, loop-mediated isothermal amplification (LAMP) combined with our DNA could detect particular alleles of M. tuberculosis RNA polymerase (rpoB) in sputum and of the melanoma-related biomarker BRAF. As one more step towards generating a true point-of-care (POC) test, we engineered DNA circuits to transduce amplicons into an off-the-shelf glucometer. Using these reactions and devices we could directly transduce Middle-East respiratory syndrome coronavirus (MERS) and Zaire Ebolavirus (Ebola) templates into glucose signals, with a sensitivity as low as 20-100 copies/µL. Virus from cell lysates and synthetic templates could be readily amplified and detected even in sputum or saliva. An OR gate that coordinately triggered on viral amplicons further guaranteed fail-safe virus detection.
Advisors/Committee Members: Ellington, Andrew D. (advisor), Brodbelt, Jennifer S. (committee member), Crooks, Richard M. (committee member), Anslyn, Eric V. (committee member), Finkelstein, Ilya J. (committee member).
Subjects/Keywords: DNA circuit; Diagnostic
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Jiang, Y. (2016). Nucleic acid circuit and its application in genetic diagnostic. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/39611
Chicago Manual of Style (16th Edition):
Jiang, Yu. “Nucleic acid circuit and its application in genetic diagnostic.” 2016. Doctoral Dissertation, University of Texas – Austin. Accessed February 27, 2021.
http://hdl.handle.net/2152/39611.
MLA Handbook (7th Edition):
Jiang, Yu. “Nucleic acid circuit and its application in genetic diagnostic.” 2016. Web. 27 Feb 2021.
Vancouver:
Jiang Y. Nucleic acid circuit and its application in genetic diagnostic. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2016. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/2152/39611.
Council of Science Editors:
Jiang Y. Nucleic acid circuit and its application in genetic diagnostic. [Doctoral Dissertation]. University of Texas – Austin; 2016. Available from: http://hdl.handle.net/2152/39611
27.
Dwire, Ashley.
Publication Bias in the Performance Diagnostic Checklist and its Variations.
Degree: Applied Behavior Analysis: M.S., Community Psychology, Counseling and Family Therapy, 2020, St. Cloud State University
URL: https://repository.stcloudstate.edu/cpcf_etds/71
► Publication bias—selectively publishing studies with positive outcomes—poses a problem to science as it can lead to inaccurate reports of intervention effects. Sham and Smith…
(more)
▼ Publication bias—selectively publishing studies with positive outcomes—poses a problem to science as it can lead to inaccurate reports of intervention effects. Sham and Smith (2014) found that the published and unpublished pivotal response treatment literature differed, calling for more investigation into behavior-analytic research for publication bias. In this study, comparisons between the published and unpublished literature on the Performance
Diagnostic Checklist, Performance
Diagnostic Checklist-Human Services, and the Performance
Diagnostic Checklist-Safety were conducted across three effect size measures: percentage of non-overlapping data, improvement rate difference, and percentage of data exceeding the median. Generally published literature outperformed the unpublished literature, providing further evidence of an overselling of results in the field.
Advisors/Committee Members: Benjamin N. Witts, Odessa Luna, Kimberly Schulze.
Subjects/Keywords: Publication Bias; Performance Diagnostic Checklist; Performance Diagnostic Checklist-Safety; Performance Diagnostic Checklist-Human Services
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Dwire, A. (2020). Publication Bias in the Performance Diagnostic Checklist and its Variations. (Masters Thesis). St. Cloud State University. Retrieved from https://repository.stcloudstate.edu/cpcf_etds/71
Chicago Manual of Style (16th Edition):
Dwire, Ashley. “Publication Bias in the Performance Diagnostic Checklist and its Variations.” 2020. Masters Thesis, St. Cloud State University. Accessed February 27, 2021.
https://repository.stcloudstate.edu/cpcf_etds/71.
MLA Handbook (7th Edition):
Dwire, Ashley. “Publication Bias in the Performance Diagnostic Checklist and its Variations.” 2020. Web. 27 Feb 2021.
Vancouver:
Dwire A. Publication Bias in the Performance Diagnostic Checklist and its Variations. [Internet] [Masters thesis]. St. Cloud State University; 2020. [cited 2021 Feb 27].
Available from: https://repository.stcloudstate.edu/cpcf_etds/71.
Council of Science Editors:
Dwire A. Publication Bias in the Performance Diagnostic Checklist and its Variations. [Masters Thesis]. St. Cloud State University; 2020. Available from: https://repository.stcloudstate.edu/cpcf_etds/71
University of Zambia
28.
Kalolo, Donald Muma.
Doctors and Nurses Knowledge and use of pain assessment tools: A case study of two tertially Hospitals
.
Degree: 2011, University of Zambia
URL: http://hdl.handle.net/123456789/559
► This study was necessitated by many gaps in pain research in Zambia. The percentage of doctors and nurses that assess pain using any indicator and…
(more)
▼ This study was necessitated by many gaps in pain research in Zambia. The percentage of doctors and nurses that assess pain using any indicator and what doctors and nurses do to treat pain. Therefore this study sought to answer the following overarching question. What do doctors and nurses do to patients that have pain?A cross-section non interventional comparative study in three clinical areas(medicine, surgery and oncology) was done using a 33 item survey questionnaire.SPSS software, version 17.0 (SPSS, Chicago, IL), was used for statistical analyses.The Pearson’s Chi-squared test was used to compare proportions. The cut off point for statistical significance was set at 5%.
Totals of 26 doctors and 76 nurses took part in the study. Concerning knowledge of
the World Health Organization Pain Relief ladder, the proportions of doctors and
nurses who reported to be aware of it was surprising low across the two professions
(Fisher’s exact test, p=0.246) with 26.9% of doctors and 15.8% of nurses reporting
being familiar with the WHO ladder. Significantly more nurses (27.6%) than doctors(3.8%) reported that doctors and nurses rated pain (2=6.48, p=0.011). Most
respondents (26.3% of doctors and 32.4% of nurses) treated pain just like all other
manifestations.Pain assessment and management are poorly done by both nurses and doctors.Though pain is assessed, it is not by using any pain assessment tools. The doctors and nurses seem to use subjective assessments in their practice. The hospital
authorities ought to endeavour to facilitate the development of pain management tools and guidelines based on local practices or consider the use of the five tools which are: Visual Assessment Scale, the Visual Rating Scale and the Numeric Pain Inventory Scale (NPIS), the Simple Descriptive Pain Intensity Scale (SDPIS) and the WHO pain ladder management tool.
Subjects/Keywords: Pain;
Pain diagnostic – Tools
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Kalolo, D. M. (2011). Doctors and Nurses Knowledge and use of pain assessment tools: A case study of two tertially Hospitals
. (Thesis). University of Zambia. Retrieved from http://hdl.handle.net/123456789/559
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Kalolo, Donald Muma. “Doctors and Nurses Knowledge and use of pain assessment tools: A case study of two tertially Hospitals
.” 2011. Thesis, University of Zambia. Accessed February 27, 2021.
http://hdl.handle.net/123456789/559.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Kalolo, Donald Muma. “Doctors and Nurses Knowledge and use of pain assessment tools: A case study of two tertially Hospitals
.” 2011. Web. 27 Feb 2021.
Vancouver:
Kalolo DM. Doctors and Nurses Knowledge and use of pain assessment tools: A case study of two tertially Hospitals
. [Internet] [Thesis]. University of Zambia; 2011. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/123456789/559.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Kalolo DM. Doctors and Nurses Knowledge and use of pain assessment tools: A case study of two tertially Hospitals
. [Thesis]. University of Zambia; 2011. Available from: http://hdl.handle.net/123456789/559
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Zambia
29.
Simukoko, Kachusi Chalumba.
Establishment and Evaluation of serological diagnostic tests for Human Cysticercosis
.
Degree: 2014, University of Zambia
URL: http://hdl.handle.net/123456789/3213
► Taenia solium (T. solium) infections are of public health concern in most developing countries where diagnosis of the diseases is still a major challenge. This…
(more)
▼ Taenia solium (T. solium) infections are of public health concern in most developing countries where diagnosis of the diseases is still a major challenge. This is due to the high cost and technique nature of most of the reliable diagnostic tools that are commercially available. In this study, serological tests developed from crude cyst antigens (Ags) of T. solium, were established at the University of Zambia, and evaluated for their sensitivity and specificity in detecting circulating cysticerci serum antibodies (Abs) in human. The crude antigen was produced from cysts of T. solium collected from pigs from rural Zambia. The antibodies –Enzyme-linked immunosorbent assay (Ab-ELISA) and Electroimmunotransfer blot (EITB) tests were evaluated using a commercial (QualiCode™ Cysticercosis Kit) Immunoblot, in order to estimate their sensitivity and specificity. The Ab-ELISA used a cut off-point of 15 antigen concentration of dilute serum. The Ab-ELISA showed a sensitivity and specificity of 16.67% and 91.94%, respectively. The crude antigen EITB used the 8-10 kDa antigenic bands to detect T. solium sera Abs in human. The commercial blot used any of the six bands 50, 42, 39, 24, 21, 18 and 14 kDa to detect T. solium sera Abs in human. Compared to the commercial blot, whose sensitivity and specificity was 98.00% and 100%, respectively, the crude antigen EITB had a sensitivity of 19.44% and specificity of 85.48%. The crude antigen EITB and Ab-ELISA tests showed significant difference (p<0.05), as the former detected more positives (25) compared to the latter (14) out of 199 samples tested.To our knowledge, this is the first study that attempted to establish an EITB from crude antigens. Most EITB that have been developed so far are based on purified antigens. The study demonstrated that the crude antigen EITB and Ab-ELISA tests are significantly less sensitive than the commercial Immunoblot test. Inspite of this, both the Ab-ELISA and EITB can be useful as screening tests in edemic areas before more sensitive and expensive tests are employed. Besides, Ab-ELISA tests have an advantage of giving the level of antibody titres in the patient’s blood, thus can be used to monitor the progress of the disease treatment. Future research should consider the use and evaluation of more immunogenic components of the cyst fluid or the use of purified or synthetic Ags, in an attempt to increase the test sensitivity.
Subjects/Keywords: Human Cysticercosis;
Serological Diagnostic Tests
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Simukoko, K. C. (2014). Establishment and Evaluation of serological diagnostic tests for Human Cysticercosis
. (Thesis). University of Zambia. Retrieved from http://hdl.handle.net/123456789/3213
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Simukoko, Kachusi Chalumba. “Establishment and Evaluation of serological diagnostic tests for Human Cysticercosis
.” 2014. Thesis, University of Zambia. Accessed February 27, 2021.
http://hdl.handle.net/123456789/3213.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Simukoko, Kachusi Chalumba. “Establishment and Evaluation of serological diagnostic tests for Human Cysticercosis
.” 2014. Web. 27 Feb 2021.
Vancouver:
Simukoko KC. Establishment and Evaluation of serological diagnostic tests for Human Cysticercosis
. [Internet] [Thesis]. University of Zambia; 2014. [cited 2021 Feb 27].
Available from: http://hdl.handle.net/123456789/3213.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Simukoko KC. Establishment and Evaluation of serological diagnostic tests for Human Cysticercosis
. [Thesis]. University of Zambia; 2014. Available from: http://hdl.handle.net/123456789/3213
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
30.
Baiche, Karim.
Surveillance automatisée de processus industriels complexes.
Degree: 2014, Université M'Hamed Bougara Boumerdès
URL: http://dlibrary.univ-boumerdes.dz:8080123456789/1446
► 114 p. : ill. ; 30 cm
Les processus industriels complexes nécessitent une méthodologie de détection rapide et précoce des défaillances dans leurs systèmes et…
(more)
▼ 114 p. : ill. ; 30 cm
Les processus industriels complexes nécessitent une méthodologie de détection rapide et précoce des défaillances dans leurs systèmes et machines à cause de l'utilisation fréquente de ces derniers dans diverses applications et domaines ainsi que leur impact socio-économique. Le travail présenté dans cette thèse évoque plusieurs approches de traitement et d'analyse appliquées au diagnostic des défauts à savoir certains défauts de machines tournantes (roulement) et défauts de capteurs (système à trois réservoirs -three tank system). Pour mettre en œuvre ce travail de recherche, nous avons établi une feuille de route selon les démarches suivantes : Etablir un état de l'art sur le principe du FDI et les différents défauts pouvant être enregistrés et identifiés. Etablir un prétraitement basé sur l'analyse spectrale avec modèle et sans modèle en utilisant les statistiques d'ordre deux et d'ordre supérieur. le premier type d'approche consiste à utiliser des modèles analytiques du processus, ceux-ci fournissent une estimation en ligne des grandeurs non mesurables. la seconde catégorie d'approche consiste à analyser les signaux mesurés sur la machine en cours de fonctionnement. Les analyses sont réalisées pour la plupart, dans le domaine fréquentiel et en régime permanent. Les informations issues de ces analyses permettent souvent une identification efficace de défaillances présentes au niveau des différents organes du processus. Toutefois ces approches fréquentielles trouvent leurs limites en présence d'importants bruits de mesure qui noient l'information pertinente. Etablir un test statistique basé sur la SPE en utilisant la MSPCA, Identifier les sources de défaillances en utilisant l'ACI
Subjects/Keywords: Diagnostic; Machines tournantes; Ondelettes appliquée
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Baiche, K. (2014). Surveillance automatisée de processus industriels complexes. (Thesis). Université M'Hamed Bougara Boumerdès. Retrieved from http://dlibrary.univ-boumerdes.dz:8080123456789/1446
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Baiche, Karim. “Surveillance automatisée de processus industriels complexes.” 2014. Thesis, Université M'Hamed Bougara Boumerdès. Accessed February 27, 2021.
http://dlibrary.univ-boumerdes.dz:8080123456789/1446.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Baiche, Karim. “Surveillance automatisée de processus industriels complexes.” 2014. Web. 27 Feb 2021.
Vancouver:
Baiche K. Surveillance automatisée de processus industriels complexes. [Internet] [Thesis]. Université M'Hamed Bougara Boumerdès; 2014. [cited 2021 Feb 27].
Available from: http://dlibrary.univ-boumerdes.dz:8080123456789/1446.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Baiche K. Surveillance automatisée de processus industriels complexes. [Thesis]. Université M'Hamed Bougara Boumerdès; 2014. Available from: http://dlibrary.univ-boumerdes.dz:8080123456789/1446
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
◁ [1] [2] [3] [4] [5] … [121] ▶
. 
Open Access Theses and Dissertations