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1.
Ndhlovu, Jacob.
Evaluation of Vitamin B12 and Folate Levels in Megaloblastic Anaemia,Diagnosed Morphologically,at the University Teaching Hospital,lusaka,Zambia.
Degree: 2016, University of Zimbabwe
URL: http://dspace.unza.zm/handle/123456789/4728
► Vitamin B12 and folate deficiency is a well-known health problem. Deficiencies of folic acid and vitamin B12 are known to cause megaloblastic anaemia, which is…
(more)
▼ Vitamin B12 and folate deficiency is a well-known health problem.
Deficiencies of folic acid and vitamin B12 are known to cause megaloblastic anaemia,
which is characterised by presence of abnormally large erythrocyte precursor cells,
megaloblasts, in the bone marrow and macrocytic red cells in the peripheral blood. These
megaloblasts arise because of impaired deoxyribonucleic acid (DNA) synthesis followed
by ineffective erythropoiesis. However, vitamin B12 or folate levels have not been
described in Zambia, whether normal levels or in relation to anaemia.
The study aimed to determine vitamin B12 and folate levels in megaloblastic
anaemia, diagnosed morphologically, in patients at the University Teaching.
This was a case control study which was undertaken at the
University Teaching Hospital (UTH) in Lusaka, Zambia. Full blood count (FBC),
Peripheral smears and ELISA were assessed on blood samples received from
megaloblastic anaemia and non-anaemic patients. The age range was between 18 – 54
years (Mean age-31 years). Among the 40 megaloblastic patients, 35% (14/40) were male
and 65% (26/40) were female with a male to female ratio of 1:1.9. Full blood count and
peripheral smear findings revealed that bicytopenia was present in 22.5% (9/40) and
pancytopenia in 72.5% (29/40) patients. Furthermore, the results showed megaloblastic
anaemia participants had statistically significant lower median vitamin B12 concentration
175 (150-333)pg/ml than non-anaemic control participants 299.5 (238-571)pg/ml
=0.0001. Megaloblastic anaemia participants also had a statistically significant lower
folate concentration (12.32± 2.28 ng/ml) than non-anaemic control participants (19.28 ±
2.84 ng/ml) =0.029. Of the megaloblastic anaemia patients, vitamin B12 deficiency was
in 60% (24/40), pure folate deficiency in 30% (12/40) and combined deficiency was
observed in 15% (6/40) patients. A weak negative correlation was found between vitamin
B12 and mean corpuscular volume but statistically significant (r= 0.0278, =0.001).
However, there was no statistical significant correlation between folate and mean
corpuscular volume (r = 0.098, = 0.326).
This study shows that majority of patients with megaloblastic anaemia,
diagnosed morphologically, at the University Teaching Hospital have a deficiency of
vitamin B12 deficiency.
Subjects/Keywords: Vitamin B12 deficiency.; Folic acid deficiency.
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APA (6th Edition):
Ndhlovu, J. (2016). Evaluation of Vitamin B12 and Folate Levels in Megaloblastic Anaemia,Diagnosed Morphologically,at the University Teaching Hospital,lusaka,Zambia. (Thesis). University of Zimbabwe. Retrieved from http://dspace.unza.zm/handle/123456789/4728
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Ndhlovu, Jacob. “Evaluation of Vitamin B12 and Folate Levels in Megaloblastic Anaemia,Diagnosed Morphologically,at the University Teaching Hospital,lusaka,Zambia.” 2016. Thesis, University of Zimbabwe. Accessed January 22, 2021.
http://dspace.unza.zm/handle/123456789/4728.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Ndhlovu, Jacob. “Evaluation of Vitamin B12 and Folate Levels in Megaloblastic Anaemia,Diagnosed Morphologically,at the University Teaching Hospital,lusaka,Zambia.” 2016. Web. 22 Jan 2021.
Vancouver:
Ndhlovu J. Evaluation of Vitamin B12 and Folate Levels in Megaloblastic Anaemia,Diagnosed Morphologically,at the University Teaching Hospital,lusaka,Zambia. [Internet] [Thesis]. University of Zimbabwe; 2016. [cited 2021 Jan 22].
Available from: http://dspace.unza.zm/handle/123456789/4728.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Ndhlovu J. Evaluation of Vitamin B12 and Folate Levels in Megaloblastic Anaemia,Diagnosed Morphologically,at the University Teaching Hospital,lusaka,Zambia. [Thesis]. University of Zimbabwe; 2016. Available from: http://dspace.unza.zm/handle/123456789/4728
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Otago
2.
Gould, Camilla Alice.
Nutritional Optic Neuropathy in Papua New Guinean Prisoners
.
Degree: 2012, University of Otago
URL: http://hdl.handle.net/10523/2095
► Since 2000, ophthalmologists providing clinical services in Madang, Papua New Guinea, have become aware of local adult prisoners presenting with gradual vision loss. An informal…
(more)
▼ Since 2000, ophthalmologists providing clinical services in Madang, Papua New Guinea, have become aware of local adult prisoners presenting with gradual vision loss. An informal assessment conducted in Beon Jail in 2007 indicated that at least 40 local inmates had a significant level of visual impairment. This was most commonly associated with atrophy of the optic nerves, a result of optic neuropathy (ON) and suspected to be caused by nutritional
deficiency.
A more detailed assessment of the prison population including clinical characterization of the ON, comprehensive dietary analysis and assessment of toxic risk factors was necessary to help determine disease aetiology and appropriate treatment for prisoners. In May 2010, a collaborative project between the Fred Hollows Foundation and the University of Otago was made to further investigate the occurrence of ON previously documented in Beon Prison.
All adult prisoners detained in Beon Prison (264 persons) were invited to participate in the study. Beon prison guards were also invited to participate on the basis of some shared environmental exposures with prisoners. Consenting participants were individually interviewed regarding demography, general and ocular health, diet and lifestyle. Participants underwent a vision and ocular examination as well as a physical examination performed by a team of trained health workers. A 24-hour dietary recall interview was performed on each participant and a venous blood sample was collected by venipuncture for the analysis of nutrients and other biomarkers. As an additional measure of dietary intake, samples (n=30) of prison rations were weighed and analysed for nutrient content. Finally, prison food samples were analysed for lead and cadmium content.
Consent was obtained for 158 prisoners and 17 prison guards. Due to a low female contingent in the prison, only data collected from males was analysed. ON was found to be present in the prisoner population. Of the prisoners examined (n=135), 14 had ‘definite’ or ‘likely’ ON and 30 had ‘possible’ ON. No guards had ‘definite’ or ‘likely’ ON. No cases of peripheral neuropathy were found in participants.
The prisoner diet predominantly consisted of rice, canned corned beef, canned tuna, water-crackers, tea and water. The fruit and vegetable consumption of the prisoners was low - 66% reported to never or rarely consume fruit and vegetables whilst in prison. Nutrient intake data generated from the 24 –hour recall suggested that less than 25% of prisoners met the estimated average requirement (EAR) for vitamin A, folate, vitamin C, vitamin E, potassium and calcium. Biochemical assessment indicated that over half of the prisoners fell below the cut-offs values of
deficiency for biochemical indicators of vitamin A, folate and vitamin C. An elevated plasma homocysteine concentration was also found in 79% of prisoners. Blood concentrations of α-tocopherol, thiamin, B12 and selenium predominantly fell within normal ranges (<5% below recommended cut-offs).
Both age and time…
Advisors/Committee Members: Venn, Bernard (advisor).
Subjects/Keywords: Optic Neuropathy;
Nutritional deficiency;
Folate deficiency
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
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APA (6th Edition):
Gould, C. A. (2012). Nutritional Optic Neuropathy in Papua New Guinean Prisoners
. (Masters Thesis). University of Otago. Retrieved from http://hdl.handle.net/10523/2095
Chicago Manual of Style (16th Edition):
Gould, Camilla Alice. “Nutritional Optic Neuropathy in Papua New Guinean Prisoners
.” 2012. Masters Thesis, University of Otago. Accessed January 22, 2021.
http://hdl.handle.net/10523/2095.
MLA Handbook (7th Edition):
Gould, Camilla Alice. “Nutritional Optic Neuropathy in Papua New Guinean Prisoners
.” 2012. Web. 22 Jan 2021.
Vancouver:
Gould CA. Nutritional Optic Neuropathy in Papua New Guinean Prisoners
. [Internet] [Masters thesis]. University of Otago; 2012. [cited 2021 Jan 22].
Available from: http://hdl.handle.net/10523/2095.
Council of Science Editors:
Gould CA. Nutritional Optic Neuropathy in Papua New Guinean Prisoners
. [Masters Thesis]. University of Otago; 2012. Available from: http://hdl.handle.net/10523/2095

Texas A&M University
3.
Rothe, Julie C.
Breeding for Tolerance of Cowpea to Low Phosphorus Soil Conditions through Physiological and Genetic Studies.
Degree: PhD, Plant Breeding, 2014, Texas A&M University
URL: http://hdl.handle.net/1969.1/152599
► Cowpea (Vigna unguiculata (L.) Walp.) is a major food legume across Sub- Saharan West Africa where its leaves, pods and seeds are consumed as food…
(more)
▼ Cowpea (Vigna unguiculata (L.) Walp.) is a major food legume across Sub-
Saharan West Africa where its leaves, pods and seeds are consumed as food and its
residues are fed to livestock as protein rich fodder. However, soils of West Africa are
poor in phosphorus (P), a soil macro-nutrient all crops need for growth. Fertilizer with P
is not readily available and is too expensive for West African farmers. This research was
therefore, undertaken to identify cowpea lines that inherently grow well in P-deficient
soils and use them to breed improved cowpea varieties that require less phosphorus
fertilization. A hydroponic phenotypic screening method with silica sand was used to
identify cowpea varieties that have tolerance to low soil P as measured by shoot dry
biomass production. Both tolerant and susceptible varieties from the screen were further
analyzed for root biomass, internal shoot P content, and internal root P content. Seed P,
particularly the effect of cotyledon P, and total root production were investigated as
physiological sources of tolerance. Tolerant cowpea varieties were crossed with
susceptible varieties, and the resulting F_(1), F_(2) and BC_(1) seeds were screened to determine
the inheritance and genetic control of tolerance. A Recombinant Inbred Line (RIL)
population of a tolerant by susceptible cross was mapped using SSR markers to identify
linkage groups or QTL for tolerance to low soil P.
Phenotypic screening results identified four cowpea varieties to have P-
deficiency
tolerance (Big John, IT97K-1069-6, IT98K-476-8, and TX2028-1-3-1) and
three cowpea varieties (Big John, CB-46, and Golden Eye Cream) to have partial P-
deficiency tolerance via high seed P content. All varieties experienced increases in root production under low P treatments relative to normal P treatments. Phenotyping of F_(1), F_(2), and BC_(1) populations showed that low P tolerance is a heritable trait in cowpea with significant additive effects and narrow-sense heritability. Estimates of gene number suggested the tolerance to be a single-gene trait. Mapping linkage groups or QTL for low P tolerance identified QTL in which three SSR markers – CLM0269, 221/222, and CLM0298 – were significantly associated with tolerance and are potential candidates for marker-assisted selection (MAS).
Advisors/Committee Members: Hays, Dirk B (advisor), Singh, Bir B (committee member), Versaw, Wayne (committee member), Provin, Tony (committee member), Jessup, Russell (committee member).
Subjects/Keywords: cowpea; phosphorus deficiency
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Rothe, J. C. (2014). Breeding for Tolerance of Cowpea to Low Phosphorus Soil Conditions through Physiological and Genetic Studies. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/152599
Chicago Manual of Style (16th Edition):
Rothe, Julie C. “Breeding for Tolerance of Cowpea to Low Phosphorus Soil Conditions through Physiological and Genetic Studies.” 2014. Doctoral Dissertation, Texas A&M University. Accessed January 22, 2021.
http://hdl.handle.net/1969.1/152599.
MLA Handbook (7th Edition):
Rothe, Julie C. “Breeding for Tolerance of Cowpea to Low Phosphorus Soil Conditions through Physiological and Genetic Studies.” 2014. Web. 22 Jan 2021.
Vancouver:
Rothe JC. Breeding for Tolerance of Cowpea to Low Phosphorus Soil Conditions through Physiological and Genetic Studies. [Internet] [Doctoral dissertation]. Texas A&M University; 2014. [cited 2021 Jan 22].
Available from: http://hdl.handle.net/1969.1/152599.
Council of Science Editors:
Rothe JC. Breeding for Tolerance of Cowpea to Low Phosphorus Soil Conditions through Physiological and Genetic Studies. [Doctoral Dissertation]. Texas A&M University; 2014. Available from: http://hdl.handle.net/1969.1/152599

University of Illinois – Urbana-Champaign
4.
Peterson, Ross D.
A photonic crystal biosensor application for assessment of iron deficiency.
Degree: PhD, Food Science & Human Nutrition, 2016, University of Illinois – Urbana-Champaign
URL: http://hdl.handle.net/2142/90918
► Iron deficiency anemia afflicts 1 in 3 individuals, mostly women and children worldwide. A novel application using iron-oxide nanoparticles (IONs) and a photonic crystal (PC)…
(more)
▼ Iron
deficiency anemia afflicts 1 in 3 individuals, mostly women and children worldwide. A novel application using iron-oxide nanoparticles (IONs) and a photonic crystal (PC) optical biosensor as an immunodiagnostic platform for detection of serum ferritin and soluble transferrin receptor (sTfR), biomarkers for iron
deficiency, is presented. Two assay formats were explored in this research: 1) standard sandwich assay (SA) and 2) inverse sandwich assay (IA). For both of these formats, total analytical error was quantified. Commercialized enzyme-linked immunosorbent assays (ELISAs) served as the reference methods to quantify the analytical error of the PC biosensor measuring both biomarkers in the IA and SA format. In the SA human liver ferritin (450 kDa), clinical serum controls, and three commercially available ferritin ELISA tests were used to evaluate the PC biosensor assay in terms of inter- and intra-assay variability, spike-recovery (%), and limit of detection (LOD). In the IA format, functionalized iron-oxide nanoparticles (fAb-IONs) were used as magnetic immuno-probes to bind sTfR (85 kDa) and minimize non-specific signals, while enhancing detection on the PC biosensor. Studies were conducted examining the binding ratios of fAb-IONs and sTfR, inherent imprecision, LOD, inter- and intra-assay replication, and nanoparticle aggregation. In both assay formats, a linear dose-response curve was elicited using the fAb-IONs. The final study was a comparison of studies experiment comparing the analytical performance of the IA on the PC biosensor to FDA-certified ELISAs measuring ferritin and sTfR. Samples from chronic kidney disease patients on hemodialysis were tested on both platforms. Total analytical error was quantified for the PC biosensor measuring ferritin and sTfR. The calculated total analytical error exceeded the quality specification for both biomarkers. Future optimization studies should aim to decrease the errors to be within the quality specifications.
Advisors/Committee Members: Andrade, Juan E (advisor), Wilund, Kenneth R (Committee Chair), Engeseth, Nicki J (committee member), Cunningham, Brian T (committee member).
Subjects/Keywords: iron deficiency; biosensor
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Peterson, R. D. (2016). A photonic crystal biosensor application for assessment of iron deficiency. (Doctoral Dissertation). University of Illinois – Urbana-Champaign. Retrieved from http://hdl.handle.net/2142/90918
Chicago Manual of Style (16th Edition):
Peterson, Ross D. “A photonic crystal biosensor application for assessment of iron deficiency.” 2016. Doctoral Dissertation, University of Illinois – Urbana-Champaign. Accessed January 22, 2021.
http://hdl.handle.net/2142/90918.
MLA Handbook (7th Edition):
Peterson, Ross D. “A photonic crystal biosensor application for assessment of iron deficiency.” 2016. Web. 22 Jan 2021.
Vancouver:
Peterson RD. A photonic crystal biosensor application for assessment of iron deficiency. [Internet] [Doctoral dissertation]. University of Illinois – Urbana-Champaign; 2016. [cited 2021 Jan 22].
Available from: http://hdl.handle.net/2142/90918.
Council of Science Editors:
Peterson RD. A photonic crystal biosensor application for assessment of iron deficiency. [Doctoral Dissertation]. University of Illinois – Urbana-Champaign; 2016. Available from: http://hdl.handle.net/2142/90918

University of Hawaii – Manoa
5.
Koshibe, Yuri.
Prevalence of signs and symptoms among iron deficient college-age individuals and its use as a predictor of iron deficiency.
Degree: 2016, University of Hawaii – Manoa
URL: http://hdl.handle.net/10125/100982
► M.S. University of Hawaii at Manoa 2012.
Non-anemic iron deficiency (NA-ID) – a condition in which hemoglobin (Hgb) and hematocrit (Hct) levels are normal, but the…
(more)
▼ M.S. University of Hawaii at Manoa 2012.
Non-anemic iron deficiency (NA-ID) – a condition in which hemoglobin (Hgb) and hematocrit (Hct) levels are normal, but the iron stores reflected by serum ferritin (sFer), are depleted – is a stage of iron deficiency that is currently not widely accepted. The objectives of this study were to explore variables that might assist with predicting NA-ID. Participants (n = 100; 65 females, 35 males) were recruited via posted flyers and were asked to complete a series of questionnaires, and a 24-hour food record. Blood pressure (BP), heart rate (HR), ear temperature, height, weight, body mass index (BMI), percent body fat, waist-to-hip ratio, Hct, Hgb, and sFer were measured. There were 45 anemic (31 females, 14 males) and 55 non-anemic (34 females, 21 males) participants. Low sFer was observed in 17 (26%) of female participants, of which 10 were anemic, and one male participant. sFer was not correlated with Hgb and Hct. The presence of two or more out of seven signs and symptoms (constipation, can't lose weight with exercise, cold when others are not, restless legs syndrome (RLS), systolic BP < 105 mmHg, depressed/sad, and sweet tooth) predicted iron deficiency (sFer < 20 ng/mL) with a sensitivity of 76% and specificity of 53%. Based on this evaluation, the group of symptoms can be used as a screening tool for blood tests beyond the basic Hgb and Hct test to assess iron status.
Subjects/Keywords: iron deficiency; college
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Koshibe, Y. (2016). Prevalence of signs and symptoms among iron deficient college-age individuals and its use as a predictor of iron deficiency. (Thesis). University of Hawaii – Manoa. Retrieved from http://hdl.handle.net/10125/100982
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Koshibe, Yuri. “Prevalence of signs and symptoms among iron deficient college-age individuals and its use as a predictor of iron deficiency.” 2016. Thesis, University of Hawaii – Manoa. Accessed January 22, 2021.
http://hdl.handle.net/10125/100982.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Koshibe, Yuri. “Prevalence of signs and symptoms among iron deficient college-age individuals and its use as a predictor of iron deficiency.” 2016. Web. 22 Jan 2021.
Vancouver:
Koshibe Y. Prevalence of signs and symptoms among iron deficient college-age individuals and its use as a predictor of iron deficiency. [Internet] [Thesis]. University of Hawaii – Manoa; 2016. [cited 2021 Jan 22].
Available from: http://hdl.handle.net/10125/100982.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Koshibe Y. Prevalence of signs and symptoms among iron deficient college-age individuals and its use as a predictor of iron deficiency. [Thesis]. University of Hawaii – Manoa; 2016. Available from: http://hdl.handle.net/10125/100982
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Arizona
6.
Radcliffe, Ivy K.
Systematic Review of Micronutrient Deficiency One Year or More After Bariatric Surgery
.
Degree: 2018, University of Arizona
URL: http://hdl.handle.net/10150/631347
► Obesity is a global epidemic and a public health challenge. Currently more than one third of adults in the United States are obese (Center for…
(more)
▼ Obesity is a global epidemic and a public health challenge. Currently more than one third of adults in the United States are obese (Center for Disease Control and Obesity, 2015). Although diet, lifestyle modification, and medications are minimally effective, bariatric surgery has demonstrated long-term weight loss and reduction of complications in obese populations.
Bariatric surgery has become the recommended treatment option for morbid obesity and obesity with comorbid disease (Buchwald et al., 2004). Studies on long-term follow up — beyond one-year post-surgery — demonstrate that bariatric surgery and extreme weight loss can cause co-morbid problems due to micronutrient deficiencies (Alvarez-Leite, 2004). Bariatric surgery and subsequent extreme weight loss can lead to malabsorption and serious complications from deficiencies in micronutrients — vitamins, minerals, and trace elements. The consequences of micronutrient deficiencies can be serious: disease, functional impairment, and decreased quality of life.
Advanced-practice nurses may not be familiar with bariatric surgeries or symptoms of micronutrient
deficiency; however, they need to develop competency to provide evidence-based primary care to the rapid growing population of patients with a history of bariatric surgery. This practice inquiry conducts an evidence-based problem-solving approach using a systematic review to develop practice guidelines for advance practice nurses to assess and prevent complications in patient’s one year or more after bariatric surgery. Results from this systematic review indicate that providers should consider screening for micronutrient deficiencies in pre- and post-operative bariatric surgery patients and that this population be routinely monitored for supplement adherence.
Advisors/Committee Members: Brewer, Barbara B (advisor), Brown, Angela C. (committeemember), Edmund, Sara J. (committeemember).
Subjects/Keywords: Bariatric Surgery;
Micronutrient;
Mineral Deficiency;
Obesity;
Trace Element Deficiency;
Vitamin Deficiency
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Radcliffe, I. K. (2018). Systematic Review of Micronutrient Deficiency One Year or More After Bariatric Surgery
. (Doctoral Dissertation). University of Arizona. Retrieved from http://hdl.handle.net/10150/631347
Chicago Manual of Style (16th Edition):
Radcliffe, Ivy K. “Systematic Review of Micronutrient Deficiency One Year or More After Bariatric Surgery
.” 2018. Doctoral Dissertation, University of Arizona. Accessed January 22, 2021.
http://hdl.handle.net/10150/631347.
MLA Handbook (7th Edition):
Radcliffe, Ivy K. “Systematic Review of Micronutrient Deficiency One Year or More After Bariatric Surgery
.” 2018. Web. 22 Jan 2021.
Vancouver:
Radcliffe IK. Systematic Review of Micronutrient Deficiency One Year or More After Bariatric Surgery
. [Internet] [Doctoral dissertation]. University of Arizona; 2018. [cited 2021 Jan 22].
Available from: http://hdl.handle.net/10150/631347.
Council of Science Editors:
Radcliffe IK. Systematic Review of Micronutrient Deficiency One Year or More After Bariatric Surgery
. [Doctoral Dissertation]. University of Arizona; 2018. Available from: http://hdl.handle.net/10150/631347

University of Otago
7.
Jack, Susan Janice.
Combating anaemia and micronutrient deficiencies among young children in rural Cambodia through in-home fortification and nutrition education.
Degree: 2012, University of Otago
URL: http://hdl.handle.net/10523/2600
► Background: Child survival is improving in Cambodia, nevertheless, 40% of Cambodian children under-five years of age are stunted and 55% are anaemic, with a peak…
(more)
▼ Background: Child survival is improving in Cambodia, nevertheless, 40% of Cambodian children under-five years of age are stunted and 55% are anaemic, with a peak anaemia prevalence in late infancy of 86%. In efficacy trials in Cambodia and elsewhere, micronutrient powders (Sprinkles) have significantly reduced anaemia. Whether this could be achieved by delivering Sprinkles through existing government health services was less certain.
Methods: A cluster-randomized trial in one rural health district of Cambodia evaluating the effectiveness of daily multi-micronutrient Sprinkles mixed with complementary foods along with infant and young child feeding (IYCF) education in infants (N = 3112) from aged 6 to 11 months, compared to IYCF education alone. We followed a randomly selected sub-sample of 1350 children at 6 monthly intervals to aged 24 months via biomarkers and anthropometry, to establish whether any observed effects on anaemia, deficiencies of iron, vitamin A, zinc, and growth were sustained.
Results:Anaemia prevalence (haemoglobin (Hb) < 110g/L) was reduced in the intervention arm compared with the control arm at the end of the intervention [aged 12 months], by 20.6% (95% CI, 9.4 to 30.2; P = 0.001), and prevalence of moderate anaemia (Hb < 100g/L) was reduced by 27.1% (95% CI, 21.0 to 31.8, P < 0.001).
The risk of anaemia (Hb < 110 g/L) and moderate anaemia (Hb < 100 g/L) was reduced by 24%, (Rate Ratio (RR) 0.76, 95% CI 0.64 to 0.89, P = 0.001), and 57% (RR 0.43, 95% CI 0.33 to 0.56, P < 0.001), respectively. At later follow-up time points there were no significant differences in anaemia between groups.
At 12 and 18 months, iron
deficiency was reduced by 23.5% (95% CI, 15.6 to 29.1; P < 0.001) and 11.6% (95% CI, 2.6 to 17.9; P = 0.02), respectively. The risk of iron
deficiency was reduced by 57% (RR 0.43, 95% CI 0.32 to 0.58, P < 0.001), and iron
deficiency anaemia (IDA) and non-IDA, were reduced for moderate anaemia at 12 months in the intervention group.
The mean serum zinc concentration was increased at 12 months (0.44 μmol/L, 95% CI 0.04 to 0.83, P = 0.028).
There were no statistically significant differences in zinc or vitamin A
deficiency, or growth at any time. Compared to national surveys, we found a slowing of stunting and underweight at 12 and 18 months, and an increase in meeting World Health Organization (WHO) recommended IYCF practices for adequate feeding at 6, 12 and 18 months.
Conclusion: Sprinkles, delivered through government health services, reduced anaemia and iron
deficiency, and increased mean serum zinc concentration in Cambodian infants. These effects were in addition to IYCF education alone, but the effects on anaemia and serum zinc concentration did not persist beyond the intervention period. This study provides clear evidence supporting the roll out of Sprinkles as a micronutrient intervention in Cambodia and similar settings. The duration should be extended to at least 18 months, and preferably 24 months of age. This study also provides indirect evidence…
Advisors/Committee Members: Herbison, Peter (advisor).
Subjects/Keywords: anaemia;
child;
Sprinkles;
micronutrient powders;
Cambodia;
nutrition;
iron deficiency;
zinc deficiency;
vitamin A deficiency
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Jack, S. J. (2012). Combating anaemia and micronutrient deficiencies among young children in rural Cambodia through in-home fortification and nutrition education.
(Doctoral Dissertation). University of Otago. Retrieved from http://hdl.handle.net/10523/2600
Chicago Manual of Style (16th Edition):
Jack, Susan Janice. “Combating anaemia and micronutrient deficiencies among young children in rural Cambodia through in-home fortification and nutrition education.
” 2012. Doctoral Dissertation, University of Otago. Accessed January 22, 2021.
http://hdl.handle.net/10523/2600.
MLA Handbook (7th Edition):
Jack, Susan Janice. “Combating anaemia and micronutrient deficiencies among young children in rural Cambodia through in-home fortification and nutrition education.
” 2012. Web. 22 Jan 2021.
Vancouver:
Jack SJ. Combating anaemia and micronutrient deficiencies among young children in rural Cambodia through in-home fortification and nutrition education.
[Internet] [Doctoral dissertation]. University of Otago; 2012. [cited 2021 Jan 22].
Available from: http://hdl.handle.net/10523/2600.
Council of Science Editors:
Jack SJ. Combating anaemia and micronutrient deficiencies among young children in rural Cambodia through in-home fortification and nutrition education.
[Doctoral Dissertation]. University of Otago; 2012. Available from: http://hdl.handle.net/10523/2600

NSYSU
8.
Shih, Yi-Ju.
Effect of YDL100c Deficiency on the Growth of Saccharomyces cerevisiae in the Presence of Zinc.
Degree: Master, Biological Sciences, 2008, NSYSU
URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0808108-102949
► ArsA is the catalytic component of an arsenite extrusion pump in E. coli that confers arsenite and antimonite resistance. YDL100cp is the ArsA homologous protein…
(more)
▼ ArsA is the catalytic component of an arsenite extrusion pump in E. coli that confers arsenite and antimonite resistance. YDL100cp is the ArsA homologous protein found in S. cerevisiae. Previous studies show that YDL100c gene is not directly related to arsenical resistance mechanism in S. cerevisiae but the YDL100c disrupted strain (KO) showed sensitivity to Zn2+ at 30 °C and more pronounced sensitivity at 37 °C. To study the role of YDL100c on Zn2+ sensitivity, wild type strain (WT) and KO were grown at 30 °C and 37 °C for 6 hr after adding Zn2+. Both strains were assayed for trehalose accumulation, intracellular oxidation level and GSH content. The results demonstrate that KO had a decreased growth and increased intracellular oxidation at 37 °C when compared to WT. Addition of Zn2+ did not increase the intracellular oxidation in WT and KO grown at 30 °C but to a greater extent in KO compared to WT grown at 37 °C. Further assess the function of antioxidant genes shows that there is no significant difference in SOD1 expression between KO and WT grown at 37 °C but CTT1 expression is low in KO. There is an increase in catalase activity for both WT and KO by adding Zn2+ at 30 °C or 37 °C, but the level of catalase activity to KO is still lower than that of WT.In conclusion, a defect of YDL100c results in a defect in the activation of general stress response at 37 °C. Consequently, the cause of the increased level of intracellular oxidation of KO in the presence of Zn2+ grown at 37 °C is most likely related to the decrease in cellular GSH content and trehalose accumulation in KO compared to that of WT. Therefore, the pronounced sensitivity to Zn2+ at 37 °C is mainly due to a defect in general stress response in KO when grown at 37 °C.
Advisors/Committee Members: Zin-Huang Liu (chair), Ching-Mei Hsu (committee member), Jong-Kang Liu (chair).
Subjects/Keywords: YDL100c Deficiency; Saccharomyces cerevisiae; Zinc
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Shih, Y. (2008). Effect of YDL100c Deficiency on the Growth of Saccharomyces cerevisiae in the Presence of Zinc. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0808108-102949
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Shih, Yi-Ju. “Effect of YDL100c Deficiency on the Growth of Saccharomyces cerevisiae in the Presence of Zinc.” 2008. Thesis, NSYSU. Accessed January 22, 2021.
http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0808108-102949.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Shih, Yi-Ju. “Effect of YDL100c Deficiency on the Growth of Saccharomyces cerevisiae in the Presence of Zinc.” 2008. Web. 22 Jan 2021.
Vancouver:
Shih Y. Effect of YDL100c Deficiency on the Growth of Saccharomyces cerevisiae in the Presence of Zinc. [Internet] [Thesis]. NSYSU; 2008. [cited 2021 Jan 22].
Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0808108-102949.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Shih Y. Effect of YDL100c Deficiency on the Growth of Saccharomyces cerevisiae in the Presence of Zinc. [Thesis]. NSYSU; 2008. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0808108-102949
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Otago
9.
Sorrenson, Brie.
Functional characterisation of ABCA1 variation
.
Degree: 2012, University of Otago
URL: http://hdl.handle.net/10523/2168
► Low levels of high-density lipoprotein cholesterol (HDL-C) are an independent risk factor for the development of cardiovascular disease (CVD). The ATP-binding cassette transporter A1 (ABCA1)…
(more)
▼ Low levels of high-density lipoprotein cholesterol (HDL-C) are an independent risk factor for the development of cardiovascular disease (CVD). The ATP-binding cassette transporter A1 (ABCA1) is a major genetic determinant of circulating HDL-C level. ABCA1 is a membrane bound transporter that is crucial to the formation of mature HDL particles though its role in facilitating efflux of cellular cholesterol and phospholipids onto lipid-poor apoA-I protein. Mutations in ABCA1 are associated with low HDL-C levels, Tangier Disease and familial hypoalphalipoprotienemia (FHA). The major aim of this study was to determine the impact of ABCA1 variation on expression and function.
Six ABCA1 mutations, identified in local low HDL-C subjects; A594T, I659V, Y1767D, R2004K, A2028V and Q2239N, were characterised in vitro using HEK293 cells transfected with ABCA1-GFP cDNA expression vectors. Functional testing, using cholesterol efflux assays, showed the mutants to have varying degrees of perturbed efflux function and confocal microscopy indicated many of the mutant proteins to be mislocalised. A further three ABCA1 mutations; C978fsX988, T1512M and N1800H, were identified and characterised within the context of a FHA pedigree. Cholesterol efflux assays, ex vivo using primary fibroblasts and in vitro using transfected HEK293 cells, showed all three mutations to impair efflux function and to be associated with disrupted sub-cellular localisation. The level of C978fsX988 mRNA was shown to be negligible in the fibroblast cultures, which precluded a dominant negative effect of the truncated allele on full-length ABCA1 alleles.
As mislocalisation correlated with impaired function for many of the mutants, the effect of the chemical chaperone, sodium 4-phenylbutyrate (4-PBA), was investigated. Treatment with 4- PBA improved localisation and efflux function for the majority of mutants in transfected HEK293 cells. This was associated with an increase in the level of ABCA1-GFP protein, likely due to stimulation of the ABCA1 expression vector CMV promoter by 4-PBA. Functional testing using primary skin fibroblasts from the available mutants however, showed an improved efflux function without any increase in ABCA1 protein expression.
The prevalence of two ABCA1 promoter polymorphisms, C-14T and G-278C was determined in a local population, where the -14T variant and the -14T, -278C haplotype were found to be associated with increased HDL-C level. Functional analysis of the two polymorphisms in isolation and in combination showed cell type specific effects on transcriptional activity, with a heightened response of the -14T genotype to agonist stimulation in HepG2 cells compared to RAW264.7 cells.
Finally, comparison of the lipid profile for subjects with low and normal HDL-C levels revealed low HDL-C to be associated with triglyceride-enrichment of apoB-containing lipoproteins, particularly very low-density lipoprotein (VLDL) and in extreme cases of FHA, low-density lipoprotein (LDL) also.
The results of this study highlight that ABCA1…
Advisors/Committee Members: McCormick, Sally (advisor).
Subjects/Keywords: ABCA1;
HDL;
familial HDL deficiency
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Sorrenson, B. (2012). Functional characterisation of ABCA1 variation
. (Doctoral Dissertation). University of Otago. Retrieved from http://hdl.handle.net/10523/2168
Chicago Manual of Style (16th Edition):
Sorrenson, Brie. “Functional characterisation of ABCA1 variation
.” 2012. Doctoral Dissertation, University of Otago. Accessed January 22, 2021.
http://hdl.handle.net/10523/2168.
MLA Handbook (7th Edition):
Sorrenson, Brie. “Functional characterisation of ABCA1 variation
.” 2012. Web. 22 Jan 2021.
Vancouver:
Sorrenson B. Functional characterisation of ABCA1 variation
. [Internet] [Doctoral dissertation]. University of Otago; 2012. [cited 2021 Jan 22].
Available from: http://hdl.handle.net/10523/2168.
Council of Science Editors:
Sorrenson B. Functional characterisation of ABCA1 variation
. [Doctoral Dissertation]. University of Otago; 2012. Available from: http://hdl.handle.net/10523/2168

Oregon State University
10.
Song, Yang.
The function of zinc in the maintenance of DNA integrity in vivo.
Degree: PhD, Nutrition, 2009, Oregon State University
URL: http://hdl.handle.net/1957/11715
► Approximately 12% of Americans do not consume the amount of zinc equal to the Estimated Average Requirement for zinc and could be at risk for…
(more)
▼ Approximately 12% of Americans do not consume the amount of zinc equal to the Estimated Average Requirement for zinc and could be at risk for marginal zinc
deficiency. Zinc is an essential component of proteins in the defense against oxidative stress and DNA damage repair. Specifically in the prostate, zinc concentrations are inversely associated with prostate malignancy. Zinc
deficiency may predispose cells to the development of cancer by increasing oxidative stress and DNA damage. Studies have shown that severe zinc-depletion increased DNA damage in testes. However, the effects of marginal zinc
deficiency, which is more prevalent in human population and physiologically relevant, are understudied. This study aimed to specify the mechanisms by which zinc status affects DNA integrity and the prostate maintains zinc level in vivo. We examined the effects of zinc
deficiency on DNA damage and oxidative stress in rat models and in human studies.
In rats, severe zinc-depletion caused an increase in DNA damage in peripheral blood cells that decreased following zinc-repletion. DNA repair functions were impaired as indicated by compromised p53 DNA binding and differential activation of DNA repair proteins. Importantly, marginal zinc-depletion (MZD) also increased DNA damage and oxidative stress, and impaired DNA repair functions. However, these effects were not observed in the prostate. Only in combination with an exogenous stress (exercise), MZD increased DNA damage in the prostate, indicating that MZD may sensitize the prostate to exogenous DNA damaging agents.
Similar to the rat study, marginal dietary zinc depletion (6wk) in healthy males increased DNA strand breaks in peripheral blood cells, alterations which were ameliorated by zinc repletion (4wk). Oxidative stress and antioxidants were not altered during zinc depletion/repletion periods.
The increases in DNA damage were associated with impaired zinc homeostasis. MZD decreased zinc concentration as well as ZnT2 expression in the prostate dorsolateral lobe, indicating disregulation of zinc transporter and zinc homeostasis.
Taken together, these studies suggest a key function of zinc in maintaining DNA integrity. Thus, the maintenance of adequate dietary zinc may have an important impact on protecting tissues, such as the prostate, from DNA damage and decreasing cancer risk.
Advisors/Committee Members: Ho, Emily (advisor), Traber, Maret G (committee member).
Subjects/Keywords: DNA damage; Zinc deficiency diseases
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Song, Y. (2009). The function of zinc in the maintenance of DNA integrity in vivo. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/11715
Chicago Manual of Style (16th Edition):
Song, Yang. “The function of zinc in the maintenance of DNA integrity in vivo.” 2009. Doctoral Dissertation, Oregon State University. Accessed January 22, 2021.
http://hdl.handle.net/1957/11715.
MLA Handbook (7th Edition):
Song, Yang. “The function of zinc in the maintenance of DNA integrity in vivo.” 2009. Web. 22 Jan 2021.
Vancouver:
Song Y. The function of zinc in the maintenance of DNA integrity in vivo. [Internet] [Doctoral dissertation]. Oregon State University; 2009. [cited 2021 Jan 22].
Available from: http://hdl.handle.net/1957/11715.
Council of Science Editors:
Song Y. The function of zinc in the maintenance of DNA integrity in vivo. [Doctoral Dissertation]. Oregon State University; 2009. Available from: http://hdl.handle.net/1957/11715

Oregon State University
11.
Ellis, William Wesley.
Tissue chemistry and attempted experimental production of white muscle disease.
Degree: PhD, Animal Husbandry, 1956, Oregon State University
URL: http://hdl.handle.net/1957/51035
Subjects/Keywords: Deficiency diseases
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APA ·
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MLA ·
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Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Ellis, W. W. (1956). Tissue chemistry and attempted experimental production of white muscle disease. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/51035
Chicago Manual of Style (16th Edition):
Ellis, William Wesley. “Tissue chemistry and attempted experimental production of white muscle disease.” 1956. Doctoral Dissertation, Oregon State University. Accessed January 22, 2021.
http://hdl.handle.net/1957/51035.
MLA Handbook (7th Edition):
Ellis, William Wesley. “Tissue chemistry and attempted experimental production of white muscle disease.” 1956. Web. 22 Jan 2021.
Vancouver:
Ellis WW. Tissue chemistry and attempted experimental production of white muscle disease. [Internet] [Doctoral dissertation]. Oregon State University; 1956. [cited 2021 Jan 22].
Available from: http://hdl.handle.net/1957/51035.
Council of Science Editors:
Ellis WW. Tissue chemistry and attempted experimental production of white muscle disease. [Doctoral Dissertation]. Oregon State University; 1956. Available from: http://hdl.handle.net/1957/51035

Cornell University
12.
Luna, Sarah.
The Effects Of Iron-Biofortified Beans On Iron Status, Physical Performance, And Physical Activity In Rwandan Women.
Degree: PhD, Nutrition, 2015, Cornell University
URL: http://hdl.handle.net/1813/41029
► Improving hemoglobin and iron status through the supplementation of high doses of iron has been shown to improve measures of physical performance such as maximal…
(more)
▼ Improving hemoglobin and iron status through the supplementation of high doses of iron has been shown to improve measures of physical performance such as maximal oxygen uptake (VO2 max) and work efficiency, which are important predictors of the ability to perform consistent physical work. The purpose of the present study was to investigate changes in physical performance and free-living physical activity in response to changes in iron status from consuming iron-biofortfied beans. One hundred and thirty-six Rwandan women age 18-27 participated in an 18-week efficacy trial designed as a randomized controlled trial. The women were randomized to one of two groups: one was served iron-biofortified beans and the other a control bean; beans are a typical part of the Rwandan diet. Iron status and physical performance were assessed at the start of the study, at one of eight randomly assigned midpoints, and at the end of 18 weeks. Physical performance was evaluated through determination of VO2 max and work efficiency using a single cycle ergometer submaximal protocol. Free-living physical activity was measured via accelerometer for five consecutive days at baseline and endline. Results show strong evidence for the efficacy of biofortified beans to improve iron status in this population. There was an overall decline in physical fitness evidenced by significant weight gain, decrease in VO2 max, and decline in minutes spent in non-sedentary physical activity. However, consuming biofortified beans attenuated the decline in VO2 max and, in a subset of participants, the decline in minutes spent in light physical activity.
Advisors/Committee Members: Haas,Jere Douglas (chair), O'Brien,Kimberly O (committee member), Mehta,Saurabh (committee member), Lujan,Marla E. (committee member), Pelletier,David Louis (committee member).
Subjects/Keywords: iron deficiency; biofortification; Rwanda
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Luna, S. (2015). The Effects Of Iron-Biofortified Beans On Iron Status, Physical Performance, And Physical Activity In Rwandan Women. (Doctoral Dissertation). Cornell University. Retrieved from http://hdl.handle.net/1813/41029
Chicago Manual of Style (16th Edition):
Luna, Sarah. “The Effects Of Iron-Biofortified Beans On Iron Status, Physical Performance, And Physical Activity In Rwandan Women.” 2015. Doctoral Dissertation, Cornell University. Accessed January 22, 2021.
http://hdl.handle.net/1813/41029.
MLA Handbook (7th Edition):
Luna, Sarah. “The Effects Of Iron-Biofortified Beans On Iron Status, Physical Performance, And Physical Activity In Rwandan Women.” 2015. Web. 22 Jan 2021.
Vancouver:
Luna S. The Effects Of Iron-Biofortified Beans On Iron Status, Physical Performance, And Physical Activity In Rwandan Women. [Internet] [Doctoral dissertation]. Cornell University; 2015. [cited 2021 Jan 22].
Available from: http://hdl.handle.net/1813/41029.
Council of Science Editors:
Luna S. The Effects Of Iron-Biofortified Beans On Iron Status, Physical Performance, And Physical Activity In Rwandan Women. [Doctoral Dissertation]. Cornell University; 2015. Available from: http://hdl.handle.net/1813/41029
13.
Gr??tzner, Niels.
Cobalamin (Vitamin B_(12)) Deficiency in the Chinese Shar Pei ??? Evaluation of a Potential Hereditary Etiology.
Degree: 2013, Texas Digital Library
URL: http://hdl.handle.net/1969;
http://hdl.handle.net/2249.1/66832
► In recent history, no other dog breed has grown in popularity and/or population size in such a short period of time as is the case…
(more)
▼ In recent history, no other dog breed has grown in popularity and/or population size in such a short period of time as is the case for the Chinese Shar Pei in North America. After being introduced to North America in the 1970s, the breed suffered from rushed breeding carried out by inexperienced breeders. This resulted not only in a dramatically different look for the Chinese Shar Pei breed, but also in a large number of health problems. A report from 1991 revealed that Chinese Shar Pei have a predisposition for cobalamin
deficiency. In this context, a comparison of serum cobalamin concentrations between dogs of different breeds would help to better understand this condition in the Chinese Shar Pei. Cobalamin-deficient Chinese Shar Peis show several clinical signs, which can be characterized by inflammatory markers, markers for chronic intestinal disease, and immunological markers. Other serum markers of cobalamin-related cellular biochemistry include homocysteine and methylmalonic acid, which are a reflection of intracellular cobalamin availability and thus might provide insights in the intracellular cobalamin metabolism in Chinese Shar Peis with cobalamin
deficiency. The Chinese Shar Pei phenotype changed over the last few decades and a survey would identify which of the two types (i.e., traditional type vs. meatmouth type) is more commonly affected with cobalamin
deficiency. Genetically speaking, genome-wide scans can be used to identify potential regions on the canine chromosome that are linked to cobalamin
deficiency in Chinese Shar Peis. Further sequencing may identify the actual mutation responsible for the condition in this breed.
Advisors/Committee Members: Steiner, J??rg M (advisor).
Subjects/Keywords: Cobalamin (vitamin B12) deficiency
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Gr??tzner, N. (2013). Cobalamin (Vitamin B_(12)) Deficiency in the Chinese Shar Pei ??? Evaluation of a Potential Hereditary Etiology. (Thesis). Texas Digital Library. Retrieved from http://hdl.handle.net/1969; http://hdl.handle.net/2249.1/66832
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Gr??tzner, Niels. “Cobalamin (Vitamin B_(12)) Deficiency in the Chinese Shar Pei ??? Evaluation of a Potential Hereditary Etiology.” 2013. Thesis, Texas Digital Library. Accessed January 22, 2021.
http://hdl.handle.net/1969; http://hdl.handle.net/2249.1/66832.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Gr??tzner, Niels. “Cobalamin (Vitamin B_(12)) Deficiency in the Chinese Shar Pei ??? Evaluation of a Potential Hereditary Etiology.” 2013. Web. 22 Jan 2021.
Vancouver:
Gr??tzner N. Cobalamin (Vitamin B_(12)) Deficiency in the Chinese Shar Pei ??? Evaluation of a Potential Hereditary Etiology. [Internet] [Thesis]. Texas Digital Library; 2013. [cited 2021 Jan 22].
Available from: http://hdl.handle.net/1969; http://hdl.handle.net/2249.1/66832.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Gr??tzner N. Cobalamin (Vitamin B_(12)) Deficiency in the Chinese Shar Pei ??? Evaluation of a Potential Hereditary Etiology. [Thesis]. Texas Digital Library; 2013. Available from: http://hdl.handle.net/1969; http://hdl.handle.net/2249.1/66832
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
14.
Velasco, Vera Marjorie Elauria.
Traits underlying phosphorus use by the extremophyte Eutrema salsugineum.
Degree: PhD, 2017, McMaster University
URL: http://hdl.handle.net/11375/21986
► The objective of this thesis was to study the response of Eutrema salsugineum (Yukon) plants to low phosphate (Pi) using seedlings and four- week-old plants…
(more)
▼ The objective of this thesis was to study the response of Eutrema salsugineum (Yukon) plants to low phosphate (Pi) using seedlings and four- week-old plants grown on media formulated with variable phosphate (Pi). Seedlings showed similar root architecture whether grown with high Pi or without added Pi. Four-week-old plants grown with 0 or 2.5 mM Pi added to the soil had the same shoot biomass and relative growth rates. Confirmation that plants on low Pi were Pi-deficient despite lacking a Pi-starvation phenotype was provided by the increased expression of Pi-starvation-inducible genes (notably EsIPS2) in Pi-deprived plants. We also found that seedling roots on media lacking Pi did not acidify their rhizosphere nor did they show increased phosphatase secretion or phosphatase activity relative to roots of Pi-sufficient seedlings. In soil-grown plants, leaf P remobilization was slower during dark-induced senescence of Eutrema relative to similarly treated, Pi-starved Arabidopsis. Also related to metabolism, in vitro assays showed that the ratio of maximal PPi- and ATP- dependent phosphofructokinase activities approximated 1:1 and 2:1 for Eutrema leaf and root extracts, respectively, with no Pi-responsive changes found and, relative to Arabidopsis, Eutrema phosphoenolpyruvate carboxylase activities were high. The enzyme activities suggest Eutrema operates glycolytic by-passes under Pi sufficient and deficient conditions. Finally, transcripts for the transcription factors Phosphate Starvation Response 1 (PHR1) and WRKY75 were not Pi-starvation-inducible and were more abundant in Eutrema leaves than in leaves of Pi-deprived Arabidopsis. Global gene expression showed the leaf and root transcriptomes to be about 90% similar between 0 and 2.5 mM Pi- treated plants with 2,901 differentially expressed genes detected by DESeq2. In summary, Eutrema displays few Pi-starvation responsive traits whether those traits reflect changes at the level of gene expression or plant morphology, behaviour consistent with a specialist that is continuously primed for Pi starvation.
Thesis
Doctor of Philosophy (PhD)
Advisors/Committee Members: Weretilnyk, Elizabeth, Biology.
Subjects/Keywords: Phosphate deficiency; Extremophyte; Thellungiella salsuginea
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MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Velasco, V. M. E. (2017). Traits underlying phosphorus use by the extremophyte Eutrema salsugineum. (Doctoral Dissertation). McMaster University. Retrieved from http://hdl.handle.net/11375/21986
Chicago Manual of Style (16th Edition):
Velasco, Vera Marjorie Elauria. “Traits underlying phosphorus use by the extremophyte Eutrema salsugineum.” 2017. Doctoral Dissertation, McMaster University. Accessed January 22, 2021.
http://hdl.handle.net/11375/21986.
MLA Handbook (7th Edition):
Velasco, Vera Marjorie Elauria. “Traits underlying phosphorus use by the extremophyte Eutrema salsugineum.” 2017. Web. 22 Jan 2021.
Vancouver:
Velasco VME. Traits underlying phosphorus use by the extremophyte Eutrema salsugineum. [Internet] [Doctoral dissertation]. McMaster University; 2017. [cited 2021 Jan 22].
Available from: http://hdl.handle.net/11375/21986.
Council of Science Editors:
Velasco VME. Traits underlying phosphorus use by the extremophyte Eutrema salsugineum. [Doctoral Dissertation]. McMaster University; 2017. Available from: http://hdl.handle.net/11375/21986

Penn State University
15.
Etter, Clara V.
The Role of Psychosocial Stress in the Etiology of Exercise-Associated Menstrual Disturbances.
Degree: 2017, Penn State University
URL: https://submit-etda.libraries.psu.edu/catalog/14750cve5047
► Abstract Background: Low energy availability and psychosocial stress have been shown to suppress reproductive function in mammals independently and in combination. The unique contributions of…
(more)
▼ Abstract
Background: Low energy availability and psychosocial stress have been shown to suppress reproductive function in mammals independently and in combination. The unique contributions of psychosocial stress on the severity of exercise associated menstrual dysfunction have not been identified and there are few prospective studies that demonstrate such effects.
Objectives: To determine the contribution of psychosocial stress to the induction of menstrual disturbances in response to a diet and exercise program that induced modest weight loss. We tested the hypothesis that increases in psychosocial stress were associated with the induction of menstrual disturbances during the original intervention.
Design: A secondary analysis was performed on data collected during a prior randomized controlled trial designed to assess the impact of three months of low (8 ± 2%), moderate (22 ± 3%), or high (42 ± 3%) levels of an energy deficit created through varying combinations of controlled caloric restriction and supervised exercise on menstrual function in ovulatory, sedentary women. We tested the hypothesis that increases in psychosocial stress were associated with the induction of menstrual disturbances during the original intervention.
Methods: In the original trial, 36 women (age 18-24 yrs, BMI 21-29 kg/m2) were studied during a Baseline menstrual cycle followed by three successive menstrual cycles during which they exercised 5 d/wk, 50-85% VO2max for 20-75 min and all food was provided to participants according to study group assignment. Metabolic and anthropometric measures were repeated throughout the intervention. Menstrual disturbances (luteal cycle defects, oligomenorrhea, and anovulation) were detected using daily measures of urinary estrone-1-glucuronide (E1G), pregnanediol glucuronide (PdG), mid-cycle luteinizing hormone (LH) and menstrual calendars. Perceived stress was measured every two weeks with the 14-item Perceived Stress Scale (Cohen, 1983). For the secondary analysis, logistic regression and chi-square analyses were performed to test the association between perceived stress and menstrual disturbances induced during the intervention. For some analyses, participants were divided into tertiles based on their change in perceived stress across the intervention: Low Stress -12.5 to 0.5 (n = 13), Moderate Stress 1.0 to 4.5 (n = 11), and High Stress 5.0 to 36.5 (n = 12). ANOVA was used to detect group differences in reproductive hormone secretion and other measures. Baseline anthropometrics, age, aerobic fitness, scores for depression and eating attitudes, and reproductive factors were investigated as possible contributors to the change in perceived stress.
Results: The intervention caused moderate weight loss (-2.57 ± 0.35 kg) and increases in aerobic fitness (p < 0.01). The change in perceived stress was a significant predictor of anovulatory cycles during the intervention such that each unit increase in change in perceived stress was associated with a 23% increase (odds ratio 1.23, 1.03 - 1.47, 95%…
Advisors/Committee Members: Nancy Williams, Thesis Advisor/Co-Advisor, Mary Jane De Souza, Committee Member, Lorah D Dorn, Committee Member.
Subjects/Keywords: energy deficiency; psychosocial stress; anovulation
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APA ·
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MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Etter, C. V. (2017). The Role of Psychosocial Stress in the Etiology of Exercise-Associated Menstrual Disturbances. (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/14750cve5047
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Etter, Clara V. “The Role of Psychosocial Stress in the Etiology of Exercise-Associated Menstrual Disturbances.” 2017. Thesis, Penn State University. Accessed January 22, 2021.
https://submit-etda.libraries.psu.edu/catalog/14750cve5047.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Etter, Clara V. “The Role of Psychosocial Stress in the Etiology of Exercise-Associated Menstrual Disturbances.” 2017. Web. 22 Jan 2021.
Vancouver:
Etter CV. The Role of Psychosocial Stress in the Etiology of Exercise-Associated Menstrual Disturbances. [Internet] [Thesis]. Penn State University; 2017. [cited 2021 Jan 22].
Available from: https://submit-etda.libraries.psu.edu/catalog/14750cve5047.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Etter CV. The Role of Psychosocial Stress in the Etiology of Exercise-Associated Menstrual Disturbances. [Thesis]. Penn State University; 2017. Available from: https://submit-etda.libraries.psu.edu/catalog/14750cve5047
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Nairobi
16.
Kirui, Winnie.
Determinants Of Sustainability Of Human Immuno Deficiency Virus Donor Funded Projects In Kenya :acase Of Kibera Slums Nairobi County
.
Degree: 2016, University of Nairobi
URL: http://hdl.handle.net/11295/100262
► For Kenya to win the war against Human Immunodeficiency Virus it needs to focus on sustaining the projects initiated by donors in light of scarce…
(more)
▼ For Kenya to win the war against Human Immunodeficiency Virus it needs to focus on sustaining the projects initiated by donors in light of scarce resources attributed to both global recession and the high burden H.I.V and A.I.D.S has placed on the government. It is worth noting that H.I.V and A.I.D.S projects are largely dependent upon funding by donors and this necessitates the need for resource maximization to ensure sustainability of the project. Human Immuno Deficiency Virus remains a major challenge in Kibera and Centre for Disease Control estimates the rate of infection to be over 20% and its in this background of this that this research sought to focus on Determinants of sustainability of Human Immuno Deficiency Virus donor funded projects in Nairobi county ,Kenya: a case of Kibera slums.The research was guided by four objectives, to determine the influence of community participation on sustainability of H.I.V and A.I.D.S projects ,to examine the influence of monitoring and evaluation on sustainability of H.I.V and A.I.D.S projects, to establish the influence of institutional environment on sustainability of H.I.V. and A.I.D.S projects and to assess the influence of project resources on sustainability of H.I.V and A.I.D.S projects. Literature reviewed defines sustainability as the continuation of benefits after major assistance from a donor has been completed and this is accurately captures the main reason for engaging in this study and explore the concept of sustainability. The study used descriptive research design in collecting the data from respondents. The design was justified for this study because it enabled the researcher to get details by analyzing the objects of study by asking questions such as who, how, what, which and when. It also provided description of the situation, thus limiting the level of biasness in the collection of data and an eventual reduction of errors in interpreting the data collected .The study used Krejcien and Morgan table to determine the sample size from the donor funded projects operating in Kibera. Respondents for the study were drawn from the target population and consisted of a project managers, project coordinators, finance managers and project officers drawn from organizations dealing with H.IV and A.I.D.S, making it a total of ninety two (92). Quantitative data which was collected using closed ended questions in the questionnaires was cleaned and tabulated. The tabulated data was analyzed using correlation and regression with the aid of SPSS 21. The regression model was used to determine if there is a relationship between dependent and independent variables. Out of the 120 distributed questionnaires, 100 we returned. The found that sustainability can only be achieved when the community is fully involved in all aspects of the project, monitoring and evaluation can not be divorced from sustainable projects.There is need to scale up monitoring and evaluation to enhance evidence based programs. Organizations should embrace and support efforts to building strong monitoring…
Subjects/Keywords: Human Immuno Deficiency Virus
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Kirui, W. (2016). Determinants Of Sustainability Of Human Immuno Deficiency Virus Donor Funded Projects In Kenya :acase Of Kibera Slums Nairobi County
. (Thesis). University of Nairobi. Retrieved from http://hdl.handle.net/11295/100262
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Kirui, Winnie. “Determinants Of Sustainability Of Human Immuno Deficiency Virus Donor Funded Projects In Kenya :acase Of Kibera Slums Nairobi County
.” 2016. Thesis, University of Nairobi. Accessed January 22, 2021.
http://hdl.handle.net/11295/100262.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Kirui, Winnie. “Determinants Of Sustainability Of Human Immuno Deficiency Virus Donor Funded Projects In Kenya :acase Of Kibera Slums Nairobi County
.” 2016. Web. 22 Jan 2021.
Vancouver:
Kirui W. Determinants Of Sustainability Of Human Immuno Deficiency Virus Donor Funded Projects In Kenya :acase Of Kibera Slums Nairobi County
. [Internet] [Thesis]. University of Nairobi; 2016. [cited 2021 Jan 22].
Available from: http://hdl.handle.net/11295/100262.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Kirui W. Determinants Of Sustainability Of Human Immuno Deficiency Virus Donor Funded Projects In Kenya :acase Of Kibera Slums Nairobi County
. [Thesis]. University of Nairobi; 2016. Available from: http://hdl.handle.net/11295/100262
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Oregon State University
17.
Adams, Frank William.
Placental resorption during vitamin E deficiency in the golden hamster (Mesocricetus auratus).
Degree: PhD, Zoology, 1965, Oregon State University
URL: http://hdl.handle.net/1957/48129
Subjects/Keywords: Deficiency diseases
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Chicago ·
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Export
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APA (6th Edition):
Adams, F. W. (1965). Placental resorption during vitamin E deficiency in the golden hamster (Mesocricetus auratus). (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/48129
Chicago Manual of Style (16th Edition):
Adams, Frank William. “Placental resorption during vitamin E deficiency in the golden hamster (Mesocricetus auratus).” 1965. Doctoral Dissertation, Oregon State University. Accessed January 22, 2021.
http://hdl.handle.net/1957/48129.
MLA Handbook (7th Edition):
Adams, Frank William. “Placental resorption during vitamin E deficiency in the golden hamster (Mesocricetus auratus).” 1965. Web. 22 Jan 2021.
Vancouver:
Adams FW. Placental resorption during vitamin E deficiency in the golden hamster (Mesocricetus auratus). [Internet] [Doctoral dissertation]. Oregon State University; 1965. [cited 2021 Jan 22].
Available from: http://hdl.handle.net/1957/48129.
Council of Science Editors:
Adams FW. Placental resorption during vitamin E deficiency in the golden hamster (Mesocricetus auratus). [Doctoral Dissertation]. Oregon State University; 1965. Available from: http://hdl.handle.net/1957/48129
18.
Kwangu, Mwenya C.
A comparative study of prevalence of Glucose-6-Phosphate Dehaydrogeanase Deficiency in essential Hypertensive and Normotensive Adults aged between 35 and 65 years at the University Teaching Hospital, Lusaka, Zambia.
Degree: 2015, University of Zimbabwe
URL: http://dspace.unza.zm/handle/123456789/3668
► BACKGROUND:Glucose-6-phosphate dehydrogenase (G6PD) enzyme deficiency is the most common enzymopathy in humans and affects over 400 million people worldwide, majority being in Africa. G6PD catalyses…
(more)
▼ BACKGROUND:Glucose-6-phosphate dehydrogenase (G6PD) enzyme deficiency is the most common enzymopathy in humans and affects over 400 million people worldwide, majority being in Africa. G6PD catalyses the first reaction of the pentose phosphate pathway where it plays a role in generation of NADPH, which is essential in reducing glutathione. In the reduced state, glutathione decreases oxidative stress. Oxidative stress has been shown to adversely affect vasodilation of small vessels which is essential for reducing blood pressure. There is however, limited scientific evidence that associates G6PD deficiency and aetiology of essential hypertension. This study aims at determining the prevalence of G6PD deficiency in both the essential hypertensive and normotensive adults, and also establishing its association to essential hypertension. It will also determine the levels of nitric oxide (NO) in both groups and its association to essential hypertension.
METHODS: An analytical cross-sectional design was applied to 89 essential hypertensive participants and 89 healthy normotensive participants, making a total of 178. All the participants were aged between 35 and 65 years. Blood was collected for G6PD activity and serum levels of NO, glucose, creatinine; and, urea and electrolytes. In addition, routine urinalysis was done. A logistic regression was used to investigate the association of age, sex, nitric oxide levels, and G6PD deficiency with essential hypertension as the dependant variable.
RESULTS: The G6PD deficiency was found in 14 (16%) participants with essential hypertension and 9 (10%) control participants. The difference however, in the G6PD deficiency prevalence rate was not statistically significant (p= 0.13). Logistic regression analysis, including G6PD deficiency, age, nitric oxide, and gender as covariates, revealed that G6PD deficiency was significantly associated with increased risk for essential hypertension (odds ratio [OR]=2.9, 95% confidence interval [CI]=1.07-7.94, p=0.036), while nitric oxide was significantly associated, but with reduced risk for essential hypertension (odds ratio [OR]=0.99, 95% confidence interval [CI]=0.98-0.99, p=0.001). The analysis further showed a significant association of age and essential hypertension, with participants in age groups 46-55 and 56-65 being at higher risk of developing essential hypertension than those in age group 35-45 (odds ratio for age groups [OR]=2.4, 95% confidence interval [CI]=1.05-5.54, p=0.037 and [OR]=7.3, [CI]=3.22-16.61,
vi
p=0.000 , respectively). The study also revealed no association between gender and essential hypertension ([OR]=0.79, [CI]=0.39-1.60, p=0.52).
CONCLUSION: The study established that the difference in the G6PD deficiency prevalence rates was not statistically significant at 0.05 significance level (p=0.13). Therefore, the results support the hypothesis that states that there is no difference in G6PD deficiency prevalence between the essential hypertensive and normotensive adults, though the study showed a possible role of G6PD…
Subjects/Keywords: Glucose-6-Phosphate Dehydrogenas Deficiency
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Kwangu, M. C. (2015). A comparative study of prevalence of Glucose-6-Phosphate Dehaydrogeanase Deficiency in essential Hypertensive and Normotensive Adults aged between 35 and 65 years at the University Teaching Hospital, Lusaka, Zambia. (Thesis). University of Zimbabwe. Retrieved from http://dspace.unza.zm/handle/123456789/3668
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Kwangu, Mwenya C. “A comparative study of prevalence of Glucose-6-Phosphate Dehaydrogeanase Deficiency in essential Hypertensive and Normotensive Adults aged between 35 and 65 years at the University Teaching Hospital, Lusaka, Zambia.” 2015. Thesis, University of Zimbabwe. Accessed January 22, 2021.
http://dspace.unza.zm/handle/123456789/3668.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Kwangu, Mwenya C. “A comparative study of prevalence of Glucose-6-Phosphate Dehaydrogeanase Deficiency in essential Hypertensive and Normotensive Adults aged between 35 and 65 years at the University Teaching Hospital, Lusaka, Zambia.” 2015. Web. 22 Jan 2021.
Vancouver:
Kwangu MC. A comparative study of prevalence of Glucose-6-Phosphate Dehaydrogeanase Deficiency in essential Hypertensive and Normotensive Adults aged between 35 and 65 years at the University Teaching Hospital, Lusaka, Zambia. [Internet] [Thesis]. University of Zimbabwe; 2015. [cited 2021 Jan 22].
Available from: http://dspace.unza.zm/handle/123456789/3668.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Kwangu MC. A comparative study of prevalence of Glucose-6-Phosphate Dehaydrogeanase Deficiency in essential Hypertensive and Normotensive Adults aged between 35 and 65 years at the University Teaching Hospital, Lusaka, Zambia. [Thesis]. University of Zimbabwe; 2015. Available from: http://dspace.unza.zm/handle/123456789/3668
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Guelph
19.
Ramsay, Lauren Calder.
A cross-sectional evaluation of sodium consumption by people in Cambodia.
Degree: MS, Department of Biomedical Sciences, 2015, University of Guelph
URL: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8684
► The cross-sectional study took place in four provinces in Cambodia: Kampot, Kandal, Kampong Chhnang and Phnom Penh. This study involved the collection of 24-hour urine…
(more)
▼ The cross-sectional study took place in four provinces in Cambodia: Kampot, Kandal, Kampong Chhnang and Phnom Penh. This study involved the collection of 24-hour urine samples to assess sodium and potassium excretion. Demographic, anthropometric, blood pressure, physical activity level, and socio-economic data were collected in face-to-face interviews. Mean urinary sodium excretion found in the 24-hour urinary sample of the entire sample population (M=5615.93mg,) is nearly three times higher than the World Health Organization recommended intake of 2000mg of sodium, p<0.001. The mean potassium excretion in 24-hours in the sample population is 3455.79mg/day. Sodium excretion has a positive linear relationship with potassium excretion, p=<0.001. There was no relationship between sodium excretion and blood pressure. The major contributors to the high-sodium diet were added seasonings daily during cooking including: salt, fish sauce, monosodium glutamate, and prahok (a locally made fish paste).
Advisors/Committee Members: Summerlee, Alastair (advisor).
Subjects/Keywords: sodium; Cambodia; potassium; iron deficiency
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Ramsay, L. C. (2015). A cross-sectional evaluation of sodium consumption by people in Cambodia. (Masters Thesis). University of Guelph. Retrieved from https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8684
Chicago Manual of Style (16th Edition):
Ramsay, Lauren Calder. “A cross-sectional evaluation of sodium consumption by people in Cambodia.” 2015. Masters Thesis, University of Guelph. Accessed January 22, 2021.
https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8684.
MLA Handbook (7th Edition):
Ramsay, Lauren Calder. “A cross-sectional evaluation of sodium consumption by people in Cambodia.” 2015. Web. 22 Jan 2021.
Vancouver:
Ramsay LC. A cross-sectional evaluation of sodium consumption by people in Cambodia. [Internet] [Masters thesis]. University of Guelph; 2015. [cited 2021 Jan 22].
Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8684.
Council of Science Editors:
Ramsay LC. A cross-sectional evaluation of sodium consumption by people in Cambodia. [Masters Thesis]. University of Guelph; 2015. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8684

University of Cape Town
20.
Lanzkowsky, Philip.
Iron-deficiency Anaemia in Infants and Pre-school children in Three Racial groups in Cape Town.
Degree: Doctoral, Medicine, 1959, University of Cape Town
URL: http://hdl.handle.net/11427/31905
► Iron-deficiency anemia is probably the commonest deficiency disease in infants and children throughout the world today. This prevalence is indeed surprising as the condition can…
(more)
▼ Iron-deficiency anemia is probably the commonest deficiency disease in infants and children throughout the world today. This prevalence is indeed surprising as the condition can be readily detected. Moreover, iron medication is cheap and for many years has been known to be effective in the prephylaxis and treatment of iron-deficiency anemia. In America, reportedly the most health-conscious of all countries, Guest and Brown (1957) have reported that the incidence, in at least one centre, is as high today as it was twenty years ago. If this is true in a country where practicing physicians are well primed about the importance of adequate nutrition, it is likely that in less-privileged communities there is probably greater failure to recognize or correct this deficiency state.
Subjects/Keywords: Iron-deficiency
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Lanzkowsky, P. (1959). Iron-deficiency Anaemia in Infants and Pre-school children in Three Racial groups in Cape Town. (Doctoral Dissertation). University of Cape Town. Retrieved from http://hdl.handle.net/11427/31905
Chicago Manual of Style (16th Edition):
Lanzkowsky, Philip. “Iron-deficiency Anaemia in Infants and Pre-school children in Three Racial groups in Cape Town.” 1959. Doctoral Dissertation, University of Cape Town. Accessed January 22, 2021.
http://hdl.handle.net/11427/31905.
MLA Handbook (7th Edition):
Lanzkowsky, Philip. “Iron-deficiency Anaemia in Infants and Pre-school children in Three Racial groups in Cape Town.” 1959. Web. 22 Jan 2021.
Vancouver:
Lanzkowsky P. Iron-deficiency Anaemia in Infants and Pre-school children in Three Racial groups in Cape Town. [Internet] [Doctoral dissertation]. University of Cape Town; 1959. [cited 2021 Jan 22].
Available from: http://hdl.handle.net/11427/31905.
Council of Science Editors:
Lanzkowsky P. Iron-deficiency Anaemia in Infants and Pre-school children in Three Racial groups in Cape Town. [Doctoral Dissertation]. University of Cape Town; 1959. Available from: http://hdl.handle.net/11427/31905

Queen Mary, University of London
21.
Kowalczyk, Julia C.
Familial glucocorticoid deficiency : new genes and mechanisms.
Degree: PhD, 2014, Queen Mary, University of London
URL: http://qmro.qmul.ac.uk/xmlui/handle/123456789/8309
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.664914
► Mutations in the melanocortin 2 receptor (MC2R) and its accessory protein (MRAP), in the ACTH signalling pathway, and the antioxidant genes nicotinamide nucleotide transhydrogenase (NNT)…
(more)
▼ Mutations in the melanocortin 2 receptor (MC2R) and its accessory protein (MRAP), in the ACTH signalling pathway, and the antioxidant genes nicotinamide nucleotide transhydrogenase (NNT) and thioredoxin reductase 2 (TXNRD2) have been associated with familial glucocorticoid deficiency (FGD). Using a tandem affinity purification and mass spectrometry approach to identify interacting partners of MC2R and MRAP failed to identify putative candidate genes for further FGD cases. However in a male patient a homozygous mutation in another antioxidant gene, glutathione peroxidase 1 (GPX1), was identified. In vitro studies showed H295R cells with knockdown of GPX1 had 50% less basal GPX activity and were less viable than wild-type when exposed to oxidative stress. Adrenals from Gpx1-/- mice showed no gross morphological changes and corticosterone levels were not significantly different from their wild-type counterparts (in contrast to the Nnt mutants). Sequencing of >100 FGD patients did not reveal any other GPX1 mutations. This equivocal data lead to the hypothesis that there could be a second gene defect present in this proband contributing to his disease. Whole exome sequencing revealed a homozygous loss-of-function mutation in peroxiredoxin 3 PRDX3 (p.Q67X) in this patient, that was also present in his unaffected brother. In vitro studies revealed both single and double knockdown of the two genes in H295R cells reduced cell viability, but redox homeostasis and cortisol production were unaffected. GPXs and PRDXs work simultaneously to reduce H2O2, preventing cellular damage. My data suggest that loss of PRDX3 alone is insufficient to cause adrenal failure and further that mutation in GPX1, either alone or in combination with PRDX3 mutation, may tip the redox balance to cause FGD.
Subjects/Keywords: 616.4; Endocrinology; familial glucocorticoid deficiency
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APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Kowalczyk, J. C. (2014). Familial glucocorticoid deficiency : new genes and mechanisms. (Doctoral Dissertation). Queen Mary, University of London. Retrieved from http://qmro.qmul.ac.uk/xmlui/handle/123456789/8309 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.664914
Chicago Manual of Style (16th Edition):
Kowalczyk, Julia C. “Familial glucocorticoid deficiency : new genes and mechanisms.” 2014. Doctoral Dissertation, Queen Mary, University of London. Accessed January 22, 2021.
http://qmro.qmul.ac.uk/xmlui/handle/123456789/8309 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.664914.
MLA Handbook (7th Edition):
Kowalczyk, Julia C. “Familial glucocorticoid deficiency : new genes and mechanisms.” 2014. Web. 22 Jan 2021.
Vancouver:
Kowalczyk JC. Familial glucocorticoid deficiency : new genes and mechanisms. [Internet] [Doctoral dissertation]. Queen Mary, University of London; 2014. [cited 2021 Jan 22].
Available from: http://qmro.qmul.ac.uk/xmlui/handle/123456789/8309 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.664914.
Council of Science Editors:
Kowalczyk JC. Familial glucocorticoid deficiency : new genes and mechanisms. [Doctoral Dissertation]. Queen Mary, University of London; 2014. Available from: http://qmro.qmul.ac.uk/xmlui/handle/123456789/8309 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.664914

University of Gothenburg / Göteborgs Universitet
22.
Abrahamsson, Kate, 1959-.
Carnitine depletion in man.
Degree: 1996, University of Gothenburg / Göteborgs Universitet
URL: http://hdl.handle.net/2077/10661
Subjects/Keywords: Carnitine: deficiency
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APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Abrahamsson, Kate, 1. (1996). Carnitine depletion in man. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/10661
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Abrahamsson, Kate, 1959-. “Carnitine depletion in man.” 1996. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed January 22, 2021.
http://hdl.handle.net/2077/10661.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Abrahamsson, Kate, 1959-. “Carnitine depletion in man.” 1996. Web. 22 Jan 2021.
Vancouver:
Abrahamsson, Kate 1. Carnitine depletion in man. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 1996. [cited 2021 Jan 22].
Available from: http://hdl.handle.net/2077/10661.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Abrahamsson, Kate 1. Carnitine depletion in man. [Thesis]. University of Gothenburg / Göteborgs Universitet; 1996. Available from: http://hdl.handle.net/2077/10661
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Victoria University of Wellington
23.
Calje, Esther.
A descriptive study of New Zealand midwives' primary care management of iron status in pregnancy and the postpartum period.
Degree: 2016, Victoria University of Wellington
URL: http://hdl.handle.net/10063/5038
► Background: Globally there is no consensus on haemoglobin (Hb) parameters that define maternal anaemia. Therefore it is difficult to distinguish physiological anaemia of pregnancy from…
(more)
▼ Background: Globally there is no consensus on haemoglobin (Hb) parameters that define maternal anaemia. Therefore it is difficult to distinguish physiological anaemia of pregnancy from anaemia associated with pathology. Low maternal iron status is associated with adverse outcomes, although the evidence is difficult to interpret. Non-anaemic iron
deficiency requires prevention and treatment, before end stage iron
deficiency anaemia. Increases in serum ferritin (SF) secondary to inflammation, gives misleading results of iron stores if not tested with C-reactive protein (CRP). Given the complexities, how do Lead Maternity Carer (LMC) midwives in New Zealand manage anaemia and iron
deficiency, without a clinical guideline?
Methods: In this descriptive study, quantitative data was retrospectively collected from September-December 2013, from LMC midwives (n=21) and women (n=189), in one New Zealand area. Main outcomes assessed were women’s iron status. Anaemia was defined as Hb <110g/L in the first trimester, <105g/L in subsequent trimesters, and <100g/L postnatally. Iron
deficiency was defined as SF <20 μg/L, if CRP<5mg/L. A secondary analysis of iron status and body mass index (BMI) was undertaken.
Results: Of the 186 women who had Hb testing at booking, 46% did not have ferritin tested concurrently. Of the 385 ferritin tests undertaken, 86% were not tested with CRP. Despite midwives prescribing iron for 48.7%, and recommending iron for 16.9% of second trimester women, 47.1% had low iron status before birth. Only 22.8% had Hb testing postpartum, including 65.1% (of 38) with blood loss >500mls. Results of a secondary analysis showed a significant difference (p=.05) between third trimester ferritin levels in women with BMI ≥ 25 (Md SF 14 μg/L) and BMI < 25 (Md SF 18 μg/L).
Conclusions: Inconsistent testing of ferritin made it difficult to assess maternal iron status, especially without concurrent testing of CRP. Midwives may not understand and recognise the progression from iron sufficiency to end-stage iron
deficiency anaemia. Even without further research this small study may indicate the need for improved education for midwives, and a clinical guideline. More complex studies on the prevalence in New Zealand, BMI and iron status, and maternal outcomes especially in the postpartum period, are warranted.
Advisors/Committee Members: Skinner, Joan.
Subjects/Keywords: Anaemia; Iron deficiency; Pregnancy
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Calje, E. (2016). A descriptive study of New Zealand midwives' primary care management of iron status in pregnancy and the postpartum period. (Masters Thesis). Victoria University of Wellington. Retrieved from http://hdl.handle.net/10063/5038
Chicago Manual of Style (16th Edition):
Calje, Esther. “A descriptive study of New Zealand midwives' primary care management of iron status in pregnancy and the postpartum period.” 2016. Masters Thesis, Victoria University of Wellington. Accessed January 22, 2021.
http://hdl.handle.net/10063/5038.
MLA Handbook (7th Edition):
Calje, Esther. “A descriptive study of New Zealand midwives' primary care management of iron status in pregnancy and the postpartum period.” 2016. Web. 22 Jan 2021.
Vancouver:
Calje E. A descriptive study of New Zealand midwives' primary care management of iron status in pregnancy and the postpartum period. [Internet] [Masters thesis]. Victoria University of Wellington; 2016. [cited 2021 Jan 22].
Available from: http://hdl.handle.net/10063/5038.
Council of Science Editors:
Calje E. A descriptive study of New Zealand midwives' primary care management of iron status in pregnancy and the postpartum period. [Masters Thesis]. Victoria University of Wellington; 2016. Available from: http://hdl.handle.net/10063/5038

University of Aberdeen
24.
Mossa-Al Hashimi, Lina.
Effect of iron deficiency on membrane structure and function.
Degree: PhD, 2013, University of Aberdeen
URL: https://eu03.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12152527110005941
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.577623
► Iron deficiency is one of the most common nutritional disorders worldwide. It is especially serious during pregnancy with serious health consequences for both the mother…
(more)
▼ Iron deficiency is one of the most common nutritional disorders worldwide. It is especially serious during pregnancy with serious health consequences for both the mother and her developing fetus. In humans these include fetal growth retardation, impaired cognitive development and premature birth. In rats, the pups born to iron deficient mothers are smaller, with changes in liver and heart size. As adults, the offspring develop hypertension and obesity. Why these changes occur is not clear. One possible hypothesis is that iron deficiency changes the cell membrane. I aimed to investigate this hypothesis, using an in-house iron deficient maternal rat model, designed by our group, additionally I have designed an iron deficient human liver hepatoma cell line model (HepG2). The effect of iron deficiency on maternal and neonatal erythrocytes membranes was tested. Iron deficiency significantly increased the mothers’ erythrocytes sensitivity to low osmotic pressure. In contrast, the neonates’ erythrocytes sensitivity was not affected by iron deficiency. The effect of iron deficiency on membrane protein profile was also studied in maternal and neonatal liver total membrane proteins, using proteomics analysis. Mitochondrial proteins were the most affected, especially in neonates. Whole cell patch clamp recording was used to study the effect of iron deficiency on the membranes’ electrophysiological properties. HepG2 cells had linear current-voltage relationships between -130 and +60 mV. Furthermore iron deficiency reduced the membranes’ input resistance reflected by an increase in holding current and in slope conductance. These changes were not reversed by K+ channel blockers (Ba2+ and quinine) suggesting no change in K+ channel protein expression. Interestingly and unexpectedly it increased the change in conductance, Sr2+ had a similar effect. Therefore iron deficient membranes had increased permeabilit
Subjects/Keywords: 616.1; Iron deficiency anemia
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APA (6th Edition):
Mossa-Al Hashimi, L. (2013). Effect of iron deficiency on membrane structure and function. (Doctoral Dissertation). University of Aberdeen. Retrieved from https://eu03.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12152527110005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.577623
Chicago Manual of Style (16th Edition):
Mossa-Al Hashimi, Lina. “Effect of iron deficiency on membrane structure and function.” 2013. Doctoral Dissertation, University of Aberdeen. Accessed January 22, 2021.
https://eu03.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12152527110005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.577623.
MLA Handbook (7th Edition):
Mossa-Al Hashimi, Lina. “Effect of iron deficiency on membrane structure and function.” 2013. Web. 22 Jan 2021.
Vancouver:
Mossa-Al Hashimi L. Effect of iron deficiency on membrane structure and function. [Internet] [Doctoral dissertation]. University of Aberdeen; 2013. [cited 2021 Jan 22].
Available from: https://eu03.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12152527110005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.577623.
Council of Science Editors:
Mossa-Al Hashimi L. Effect of iron deficiency on membrane structure and function. [Doctoral Dissertation]. University of Aberdeen; 2013. Available from: https://eu03.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12152527110005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.577623

McGill University
25.
Sella, Gabriel Eugen.
Influence of Zinc Deficiency on growth and Sexual Development in Rats.
Degree: MS, Department of Physiology, 1979, McGill University
URL: https://escholarship.mcgill.ca/downloads/4q77ft89w.pdf
;
https://escholarship.mcgill.ca/concern/theses/tb09j783q
► Les processus de l'accroissement somatique et de la saturation et activité sexuelle ont été étudiés dans l'optique de la carence metabolique nutritionnelle du zinc, dans…
(more)
▼ Les processus de l'accroissement somatique et de la saturation et activité sexuelle ont été étudiés dans l'optique de la carence metabolique nutritionnelle du zinc, dans le rat femelle. La carence en zinc est une condition nutritionnelle dysmetabolique rencontrée dans la nature. Ses consequences, refletées par le model adopté, y sont l'arrêt de la croissance corporelle et le délai on manque de développement sexuel dans les jeunes femelles. Chez les adultes, la carence en zinc inhibe, au mains partiellement, les fonctions sexuelles. L'induction pharmacologique de la puberté précoce ne parte que sur les organes périphériques (i.e. l'ovaire, l'uterus} mais n'influence pas le niveau hypophysaire. Les déterminations obtenues de l' hormone somatotrophe (GH), de l'insuline et de la thyroxine reflètent les consequences observables de l'arrêt de la croissance. L'absence de la puberté est accompagnée par une baisse des gonadotropines, de la prolactine et des hormones steroides sexuelles. L'ensemble des resultats des dosages hormonaux est indicatif du fait que la carence en zinc est nuisible au fonctionnement de 1 'axe pituitaire - organes sexuels, étant compatible avec le nanisme et l'hypogonadisme.
The processes of somatic growth and sexual maturation and activity have been investigated in the light of the metabolic model of nutritional zinc deficiency, in female rats. Zinc deficiency is a dysmetabolic nutritional condition encountered in nature. Its consequences, mirrored by the model adopted, are growth arrest or delay and lack of sexual maturation in the young. Zinc deficiency in adult female rats inhibits, at least in part, sexual functions. Pharmacologic induction of precocious sexual maturation meets with success only at the end-organ {i.e. ovary, uterus) level. The observable pattern of growth arrest is paralleled by low levels of growth hormone, insulin and thyroxine, as determined. The absence of sexual maturation and activity are paralleled by low levels of FSH, LH, PRL and steroid sex hormones, as determined. The results obtained from the hormonal determinations done indicate that zinc deficiency affects significantly the pituitary-endorgan axis, being causal to dwarfism and hypogonadism.
Advisors/Committee Members: Ruf, K. B. (Supervisor).
Subjects/Keywords: Zinc deficiency
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Sella, G. E. (1979). Influence of Zinc Deficiency on growth and Sexual Development in Rats. (Masters Thesis). McGill University. Retrieved from https://escholarship.mcgill.ca/downloads/4q77ft89w.pdf ; https://escholarship.mcgill.ca/concern/theses/tb09j783q
Chicago Manual of Style (16th Edition):
Sella, Gabriel Eugen. “Influence of Zinc Deficiency on growth and Sexual Development in Rats.” 1979. Masters Thesis, McGill University. Accessed January 22, 2021.
https://escholarship.mcgill.ca/downloads/4q77ft89w.pdf ; https://escholarship.mcgill.ca/concern/theses/tb09j783q.
MLA Handbook (7th Edition):
Sella, Gabriel Eugen. “Influence of Zinc Deficiency on growth and Sexual Development in Rats.” 1979. Web. 22 Jan 2021.
Vancouver:
Sella GE. Influence of Zinc Deficiency on growth and Sexual Development in Rats. [Internet] [Masters thesis]. McGill University; 1979. [cited 2021 Jan 22].
Available from: https://escholarship.mcgill.ca/downloads/4q77ft89w.pdf ; https://escholarship.mcgill.ca/concern/theses/tb09j783q.
Council of Science Editors:
Sella GE. Influence of Zinc Deficiency on growth and Sexual Development in Rats. [Masters Thesis]. McGill University; 1979. Available from: https://escholarship.mcgill.ca/downloads/4q77ft89w.pdf ; https://escholarship.mcgill.ca/concern/theses/tb09j783q

University of Texas – Austin
26.
Chirayil, Rachel.
Impact of non-coding RNAs in genetic disease and papillomavirus lifecycle.
Degree: MSin Science and Technology Commercialization, Microbiology, 2017, University of Texas – Austin
URL: http://dx.doi.org/10.26153/tsw/3197
► Non-coding RNAs are vital to several diverse biological processes. Untranslated regions of mRNAs (UTRs) and variability therein can often cause differential regulation of transcripts. This…
(more)
▼ Non-coding RNAs are vital to several diverse biological processes. Untranslated regions of mRNAs (UTRs) and variability therein can often cause differential regulation of transcripts. This regulation is often effected by microRNAs (miRNAs), small non-coding RNAs that interacts with 3’UTRs to regulate gene expression post-transcriptionally. Here we investigate the variation in the 3’UTR of SERPINA1 gene, mutations of which cause the often life-threatening Alpha-1-antitrypsin
deficiency (A1AD), and effects on miRNA. We screened 50 miRNA mimics and determined their overexpression does not affect secreted alpha-1-antitrypsin (AAT). Additionally, we showed through the use of a poxvirus protein to degrade miRNAs that underexpression of miRNAs does not affect secreted AAT. Using luciferase reporters we determine that in cultured cells, there are no liver-specific trans-factors that act on the SERPINA1 3’UTR, of any length, to regulate gene expression. We sequenced the 3’UTRs from the largest cohort of of A1AD patients to date and determined that 3’UTR variation does not contribute to disease severity in patients with one form of A1AD, and that in a cell culture context, miRNAs do not regulate secreted AAT. We conclude that neither 3’UTR variation nor miRNAs affect wild-type secreted AAT.
In addition to genetic disease, miRNAs regulate multiple aspects of the host-pathogen interface. Until now no widely accepted PV-encoded miRNAs have been described. We have developed miRNA Discovery by forced Genomic Expression (miDGE), a new wet bench approach to miRNA identification that screens numerous pathogen genomes in parallel. Using miDGE, we screened over 75 different PV genomes for the ability to code for miRNAs. We conclusively demonstrate a lack of PV miRNA expression in cancers associated with infections of several high risk HPVs. However, we identified five different miRNAs encoded by four different PVs (Human PVs 17, 37, 41 and Fringilla colebs (Fc) PV). We show that miRNAs from two PVs (HPV41 & FcPV) are able to regulate transcripts corresponding to the early region of the PV genome.. Combined, these findings identify the first canonical PV miRNAs and support that miRNAs of either host or viral origin are important regulators of the PV life cycle.
Advisors/Committee Members: Sullivan, Christopher S. (advisor).
Subjects/Keywords: Alpha-1-antitrypson deficiency; Papillomaviruses
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Chirayil, R. (2017). Impact of non-coding RNAs in genetic disease and papillomavirus lifecycle. (Masters Thesis). University of Texas – Austin. Retrieved from http://dx.doi.org/10.26153/tsw/3197
Chicago Manual of Style (16th Edition):
Chirayil, Rachel. “Impact of non-coding RNAs in genetic disease and papillomavirus lifecycle.” 2017. Masters Thesis, University of Texas – Austin. Accessed January 22, 2021.
http://dx.doi.org/10.26153/tsw/3197.
MLA Handbook (7th Edition):
Chirayil, Rachel. “Impact of non-coding RNAs in genetic disease and papillomavirus lifecycle.” 2017. Web. 22 Jan 2021.
Vancouver:
Chirayil R. Impact of non-coding RNAs in genetic disease and papillomavirus lifecycle. [Internet] [Masters thesis]. University of Texas – Austin; 2017. [cited 2021 Jan 22].
Available from: http://dx.doi.org/10.26153/tsw/3197.
Council of Science Editors:
Chirayil R. Impact of non-coding RNAs in genetic disease and papillomavirus lifecycle. [Masters Thesis]. University of Texas – Austin; 2017. Available from: http://dx.doi.org/10.26153/tsw/3197

Oklahoma State University
27.
Shawron, Krista.
Iron Deficiency Negatively Affects Bone Quality and Microarchitecture in Weanling Male Sprague Dawley Rats.
Degree: Department of Nutritional Sciences, 2011, Oklahoma State University
URL: http://hdl.handle.net/11244/9281
► The objective of this study was to examine the effects of severe iron restriction on bone microarchitecture and begin to characterize the mechanism by which…
(more)
▼ The objective of this study was to examine the effects of severe iron restriction on bone microarchitecture and begin to characterize the mechanism by which this occurs. Weanling Sprague Dawley rats were assigned to one of three dietary treatments for 35 days: severe iron restriction (< 3 mg Fe/kg diet), control (50 mg Fe/kg diet), or pair-fed control diet to the level of intake of the iron restricted animals. Analysis of bone mineral density (BMD) and microarchitecture were obtained by DXA and microcomputed tomography (CT) in both the tibia and spine. RNA was extracted from the femur and used to synthesize cDNA for quantitative real-time polymerase chain reactions (qPCR).Iron deficiency was confirmed by the expression of transferrin receptor mRNA in bone marrow cells (3.6-fold higher in iron-restricted animals, p<0.05). BMD (-12%) and bone microarchitecture of spines from animals receiving both levels of iron restriction were decreased (p<0.05), whereas no changes were observed in the tibia. Trabecular number and thickness were significantly decreased (p<0.001) coupled with an increase in trabecular separation in the spine. mRNA expression analysis revealed significant down-regulation of key osteogenic factors including Runx2, osterix, and bone morphogenetic protein-2 (BMP-2). Our findings indicate that iron deficiency negatively impact the differentiation and maturation of mesenchymal stem cells into osteoblasts, based on the observed decrease in expression of BMP-2, Runx2, and osterix. Thus, our results demonstrate that severe iron deficiency during a period of rapid growth is very likely a risk factor for osteoporosis, and future research regarding the mechanism by which this occurs is warranted.
Subjects/Keywords: bone; iron deficiency; microarchitecture
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APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Shawron, K. (2011). Iron Deficiency Negatively Affects Bone Quality and Microarchitecture in Weanling Male Sprague Dawley Rats. (Thesis). Oklahoma State University. Retrieved from http://hdl.handle.net/11244/9281
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Shawron, Krista. “Iron Deficiency Negatively Affects Bone Quality and Microarchitecture in Weanling Male Sprague Dawley Rats.” 2011. Thesis, Oklahoma State University. Accessed January 22, 2021.
http://hdl.handle.net/11244/9281.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Shawron, Krista. “Iron Deficiency Negatively Affects Bone Quality and Microarchitecture in Weanling Male Sprague Dawley Rats.” 2011. Web. 22 Jan 2021.
Vancouver:
Shawron K. Iron Deficiency Negatively Affects Bone Quality and Microarchitecture in Weanling Male Sprague Dawley Rats. [Internet] [Thesis]. Oklahoma State University; 2011. [cited 2021 Jan 22].
Available from: http://hdl.handle.net/11244/9281.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Shawron K. Iron Deficiency Negatively Affects Bone Quality and Microarchitecture in Weanling Male Sprague Dawley Rats. [Thesis]. Oklahoma State University; 2011. Available from: http://hdl.handle.net/11244/9281
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Georgia
28.
Shim, Mi Yeon.
Performance and bone quality of modern broiler chicks as influenced by hens' age and egg storage time.
Degree: 2014, University of Georgia
URL: http://hdl.handle.net/10724/23989
► The Hens’ age has been shown to influence bone quality, especially TD. Egg storage time has been shown to influence chick quality. Four experiments were…
(more)
▼ The Hens’ age has been shown to influence bone quality, especially TD. Egg storage time has been shown to influence chick quality. Four experiments were conducted with chicks hatched from eggs laid by Ross × Ross 308 hens to investigate the
influence of hens’ age and egg storage time (0 vs. 10 d) on egg parameters, chick growth and bone abnormalities in progeny as influenced by diets formulated to induce tibial dyschondroplasia (TD) or rickets. The diets were based on corn, soybean meal and
soybean oil. The TD-inducing diet contained 0.60 % Ca and 0.50 % available P and the Phosphorous (P) rickets-inducing diet contained 1.00 % Ca and 0.25 % available P. The hens’ age had significant effects on 0 - 16 d chick growth and the score and
incidence of TD. The egg storage time had significant effects on the score and incidence of P rickets. The 1 .-OH cholecalciferol (vitamin D3) had significant effects on the score and incidence of P rickts and chick mortality (%) for 16 d.
Subjects/Keywords: P deficiency; VItamin D deficiency; Age; Egg Storage; Broilers
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APA ·
Chicago ·
MLA ·
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CSE |
Export
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APA (6th Edition):
Shim, M. Y. (2014). Performance and bone quality of modern broiler chicks as influenced by hens' age and egg storage time. (Thesis). University of Georgia. Retrieved from http://hdl.handle.net/10724/23989
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Shim, Mi Yeon. “Performance and bone quality of modern broiler chicks as influenced by hens' age and egg storage time.” 2014. Thesis, University of Georgia. Accessed January 22, 2021.
http://hdl.handle.net/10724/23989.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Shim, Mi Yeon. “Performance and bone quality of modern broiler chicks as influenced by hens' age and egg storage time.” 2014. Web. 22 Jan 2021.
Vancouver:
Shim MY. Performance and bone quality of modern broiler chicks as influenced by hens' age and egg storage time. [Internet] [Thesis]. University of Georgia; 2014. [cited 2021 Jan 22].
Available from: http://hdl.handle.net/10724/23989.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Shim MY. Performance and bone quality of modern broiler chicks as influenced by hens' age and egg storage time. [Thesis]. University of Georgia; 2014. Available from: http://hdl.handle.net/10724/23989
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of South Africa
29.
Wegderes Ketema Bekele.
Food-based strategies to improve iron status of pregnant women : randomized controlled trial.
Degree: 2019, University of South Africa
URL: http://hdl.handle.net/10500/25801
► This parallel randomized control trial study assessed the effect of food-based strategies in improving the haemoglobin level; decreasing anaemia and thus the iron status of…
(more)
▼ This parallel randomized control trial study assessed the effect of food-based strategies in improving the haemoglobin level; decreasing anaemia and thus the iron status of pregnant women. The study randomized 195 anaemic women enrolled from four randomly selected health centres in Dire Dawa while attending ANC into two intervention groups and control; and followed for 12weeks. The study intervened diet-based supplementation of 90mg/day vitamin C divided and consumed in three doses; combined with nutrition education intervention in intervention group 1; while only nutrition education intervention in group 2. Dietary diversity was assessed using past 24-hours and 7-days dietary recall approaches and haemoglobin levels were determined at baseline and end-line and compared to analyse treatment effects. By end of the study, intervention group 1 and 2 had significantly increased mean haemoglobin by 0.77 ± 0.11gm/dl and 0.398 ± 0.073gm/dl respectively;
however, the control had significant decrease by -0.193 ± 0.05gm/dl. Anaemia prevalence also significantly decreased by 29% and 19.7% in intervention group 1 and 2 respectively. However, all women in the control were anaemic. Intervention group 1 and 2 also had significantly higher dietary diversity, consumption of vitamin C-rich fruits and vegetables, nutritional knowledge and modification practices. The researcher thus concludes that diet-based vitamin C supplementation integrated with nutrition education has a significant effect in improving haemoglobin, decreasing anaemia and thus improving the iron status of pregnant women in Dire Dawa. Based on the findings, the researcher developed a framework for an integrated food-based strategy for improving the iron status of pregnant women in Ethiopia.
Advisors/Committee Members: Mavhandu-Mudzusi, A. H (advisor).
Subjects/Keywords: Anaemia; Food-based strategy; Iron deficiency; Iron deficiency anaemia; Pregnant woman
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APA (6th Edition):
Bekele, W. K. (2019). Food-based strategies to improve iron status of pregnant women : randomized controlled trial. (Doctoral Dissertation). University of South Africa. Retrieved from http://hdl.handle.net/10500/25801
Chicago Manual of Style (16th Edition):
Bekele, Wegderes Ketema. “Food-based strategies to improve iron status of pregnant women : randomized controlled trial.” 2019. Doctoral Dissertation, University of South Africa. Accessed January 22, 2021.
http://hdl.handle.net/10500/25801.
MLA Handbook (7th Edition):
Bekele, Wegderes Ketema. “Food-based strategies to improve iron status of pregnant women : randomized controlled trial.” 2019. Web. 22 Jan 2021.
Vancouver:
Bekele WK. Food-based strategies to improve iron status of pregnant women : randomized controlled trial. [Internet] [Doctoral dissertation]. University of South Africa; 2019. [cited 2021 Jan 22].
Available from: http://hdl.handle.net/10500/25801.
Council of Science Editors:
Bekele WK. Food-based strategies to improve iron status of pregnant women : randomized controlled trial. [Doctoral Dissertation]. University of South Africa; 2019. Available from: http://hdl.handle.net/10500/25801

University of Toronto
30.
Khan, Waqas Ullah.
Controlling Iron Defeciency Anemia and Preventing Calcium Deficiency in Bangladesh Children: A Novel Approach Using a Multi-micronutrient Powder (MNP) Formulation.
Degree: 2011, University of Toronto
URL: http://hdl.handle.net/1807/29576
► Iron deficiency anemia (IDA) and calcium deficiency affect millions of children globally. Sprinkles is a multi-micronutrient powder (MNP) that has successfully treated anemic infants and…
(more)
▼ Iron deficiency anemia (IDA) and calcium deficiency affect millions of children globally. Sprinkles is a multi-micronutrient powder (MNP) that has successfully treated anemic infants and can be modified to include additional micronutrients. The efficacy for treating IDA and preventing calcium deficiency requires evaluation due to potential nutrient interactions. We assessed the efficacy of Sprinkles MNP including iron with and without calcium on hemoglobin (Hb) response in 100 anemic rural Bangladeshi infants for 2 months. Sprinkles MNP with and without calcium resulted in a significantly higher Hb concentrations in both groups (P<0.0001 and P<0.0001). However, infants who received Sprinkles MNP without calcium had a significantly higher change in Hb concentration (P=0.024) and rate of recovery from anemia (P=0.008). No differences in socio-demographic or dietary characteristics were documented between groups. Although both groups had an improvement in Hb status, the antagonistic interaction between iron and calcium requires further study.
MAST
Advisors/Committee Members: Zlotkin, Stanley H., Nutritional Sciences.
Subjects/Keywords: Iron Deficiency Anemia; Calcium Deficiency; Nutrient-Nutrient Interaction; Micronutrient Powder; 0570
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Khan, W. U. (2011). Controlling Iron Defeciency Anemia and Preventing Calcium Deficiency in Bangladesh Children: A Novel Approach Using a Multi-micronutrient Powder (MNP) Formulation. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/29576
Chicago Manual of Style (16th Edition):
Khan, Waqas Ullah. “Controlling Iron Defeciency Anemia and Preventing Calcium Deficiency in Bangladesh Children: A Novel Approach Using a Multi-micronutrient Powder (MNP) Formulation.” 2011. Masters Thesis, University of Toronto. Accessed January 22, 2021.
http://hdl.handle.net/1807/29576.
MLA Handbook (7th Edition):
Khan, Waqas Ullah. “Controlling Iron Defeciency Anemia and Preventing Calcium Deficiency in Bangladesh Children: A Novel Approach Using a Multi-micronutrient Powder (MNP) Formulation.” 2011. Web. 22 Jan 2021.
Vancouver:
Khan WU. Controlling Iron Defeciency Anemia and Preventing Calcium Deficiency in Bangladesh Children: A Novel Approach Using a Multi-micronutrient Powder (MNP) Formulation. [Internet] [Masters thesis]. University of Toronto; 2011. [cited 2021 Jan 22].
Available from: http://hdl.handle.net/1807/29576.
Council of Science Editors:
Khan WU. Controlling Iron Defeciency Anemia and Preventing Calcium Deficiency in Bangladesh Children: A Novel Approach Using a Multi-micronutrient Powder (MNP) Formulation. [Masters Thesis]. University of Toronto; 2011. Available from: http://hdl.handle.net/1807/29576
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