subject:(damage)

Texas A&M University

1. McLendon, Wesley R. Prediction of Damage Zone Growth in Composites Using Continuum Damage Mechanics.

Degree: 2010, Texas A&M University

URL: http://hdl.handle.net/1969.1/ETD-TAMU-2009-12-7509

► The continuum damage mechanics (CDM) approach is widely used to model damage in polymer matrix composite materials which are represented using the homogenized properties of… (more)

Subjects/Keywords: composite; damage; continuum damage mechanics

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

McLendon, W. R. (2010). Prediction of Damage Zone Growth in Composites Using Continuum Damage Mechanics. (Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/ETD-TAMU-2009-12-7509

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

McLendon, Wesley R. “Prediction of Damage Zone Growth in Composites Using Continuum Damage Mechanics.” 2010. Thesis, Texas A&M University. Accessed February 22, 2020. http://hdl.handle.net/1969.1/ETD-TAMU-2009-12-7509.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

McLendon, Wesley R. “Prediction of Damage Zone Growth in Composites Using Continuum Damage Mechanics.” 2010. Web. 22 Feb 2020.

Vancouver:

McLendon WR. Prediction of Damage Zone Growth in Composites Using Continuum Damage Mechanics. [Internet] [Thesis]. Texas A&M University; 2010. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2009-12-7509.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

McLendon WR. Prediction of Damage Zone Growth in Composites Using Continuum Damage Mechanics. [Thesis]. Texas A&M University; 2010. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2009-12-7509

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Hawaii – Manoa

2. Sil, Payel. Role of γ-H2AX in DNA damage response.

Degree: 2016, University of Hawaii – Manoa

URL: http://hdl.handle.net/10125/101438

►

M.S. University of Hawaii at Manoa 2011.

Little is known about the molecular mechanism of γ-H2AX in DNA damage response in mammalian embryos when compared… (more)

Subjects/Keywords: DNA damage

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sil, P. (2016). Role of γ-H2AX in DNA damage response. (Thesis). University of Hawaii – Manoa. Retrieved from http://hdl.handle.net/10125/101438

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sil, Payel. “Role of γ-H2AX in DNA damage response.” 2016. Thesis, University of Hawaii – Manoa. Accessed February 22, 2020. http://hdl.handle.net/10125/101438.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sil, Payel. “Role of γ-H2AX in DNA damage response.” 2016. Web. 22 Feb 2020.

Vancouver:

Sil P. Role of γ-H2AX in DNA damage response. [Internet] [Thesis]. University of Hawaii – Manoa; 2016. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/10125/101438.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sil P. Role of γ-H2AX in DNA damage response. [Thesis]. University of Hawaii – Manoa; 2016. Available from: http://hdl.handle.net/10125/101438

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Hong Kong

3. Ng, Ho-wang, Howin. The functional study of negative regulators in DNA damage responses.

Degree: Master of Medical Sciences, 2016, University of Hong Kong

URL: http://hdl.handle.net/10722/236252

►

The DNA damage response (DDR) has a pivotal role in safeguarding genome integrity in cells, hence preventing genomic instability, one of the hallmarks of cancer.… (more)

▼

The DNA damage response (DDR) has a pivotal role in safeguarding genome integrity in cells, hence preventing genomic instability, one of the hallmarks of cancer. Here, the current dissertation details parts to two ongoing studies that characterise USP7, RNF169 and DYRK1A as candidate negative regulators of DNA double-strand break (DSB) repair processes. DSBs represent one class of the most deleterious types of DNA damage. Additionally, aberrant expression of USP7, RNF169 or DYRK1A has been detected in several types of cancer. DYRK1A, in particularly, contributes to pathogenesis of Down syndrome and promotes Down syndrome-related acute megakaryoblastic leukaemia (DS-AMkL). In this study, USP7 and RNF169 knockout HeLa cells were generated using the CRISPR-Cas9 approach. From reconstituted cell lines, it was observed that both USP7 and RNF169 confer cellular resistance to poly(ADP-ribose) polymerase inhibitor Olaparib. Given that cells with deficiency in DSB repair by homologous recombination (HR) are hypersensitive to Olaparib, this supports the hypothesis that USP7 and RNF169 promotes DSB repair via the high fidelity HR pathway. Moreover, inactivation of USP7 deubiquitinase (DUB) activity or disruption of the USP7-RNF169 interaction compromised HR repair, suggesting that both USP7 DUB and its interaction with RNF169 are required for HR-dependent DSB repair. Secondly, DYRK1A depletion by RNA interference led to supra-physiological capacity of DSB repair by both HR and non-homologous end joining (NHEJ), while no major change in cell cycle distribution or dynamics of irradiation induced checkpoint response was observed. The findings reflect the suppressive nature of DYRK1A on overall DSB repair, possibly as a result of DYRK1A’s ability to limit the assembly of repair factors at sites of DSBs. Together, the present work encourages further clinical studies on the association of negative DDR regulations and disease pathogenesis.

published_or_final_version

Biomedical Sciences

Master

Master of Medical Sciences

Subjects/Keywords: DNA damage

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ng, Ho-wang, H. (2016). The functional study of negative regulators in DNA damage responses. (Masters Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/236252

Chicago Manual of Style (16^th Edition):

Ng, Ho-wang, Howin. “The functional study of negative regulators in DNA damage responses.” 2016. Masters Thesis, University of Hong Kong. Accessed February 22, 2020. http://hdl.handle.net/10722/236252.

MLA Handbook (7^th Edition):

Ng, Ho-wang, Howin. “The functional study of negative regulators in DNA damage responses.” 2016. Web. 22 Feb 2020.

Vancouver:

Ng, Ho-wang H. The functional study of negative regulators in DNA damage responses. [Internet] [Masters thesis]. University of Hong Kong; 2016. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/10722/236252.

Council of Science Editors:

Ng, Ho-wang H. The functional study of negative regulators in DNA damage responses. [Masters Thesis]. University of Hong Kong; 2016. Available from: http://hdl.handle.net/10722/236252

4. Shakiba, Maryam. A Continuum Coupled Moisture-mechanical Constitutive Model for Asphalt Concrete.

Degree: 2013, Texas Digital Library

URL: http://hdl.handle.net/1969; http://hdl.handle.net/2249.1/66856

► The presence and flow of moisture degrade engineering properties of asphalt concrete as part of thermodynamic, chemical, physical, and mechanical processes. This detrimental effect is… (more)

▼ The presence and flow of moisture degrade engineering properties of asphalt concrete as part of thermodynamic, chemical, physical, and mechanical processes. This detrimental effect is referred to as moisture damage. The aim of this dissertation is the development of physically based constitutive relationships along with a computational tool for the fundamental analysis of combined mechanical and moisture induced damage of asphalt concrete. Such a tool can greatly contribute to an improved material selection procedure and give insight into the various damage inducing mechanisms in asphalt concrete. In this dissertation, thermo-hygro-mechanical constitutive relationships are developed based on the principle of virtual power and laws of thermodynamics in order to simulate moisture-induced damage of asphalt concrete. An evolution function is proposed to consider the detrimental effect of moisture diffusion and presence inside the material. The effect of pore water pressure is incorporated using Biot???s coefficient. The Continuum Damage Mechanics (CDM) theory is extended to Continuum Moisture-Mechanical Damage Mechanics (CMMDM) to incorporate the moisture degradation effect and couple it to the mechanical response of asphalt concrete. The proposed moisture damage constitutive relationships are implemented in the Pavement Analysis using Nonlinear Damage Approach (PANDA) finite element (FE) package to model the moisture damage effect on the complex environmental-mechanical response of asphalt concrete. The developed constitutive relationship and framework are validated over different loading scenarios and a range of experimental measurements. The developed constitutive relationship and framework are applied to simulate pavement performance. The focus is on investigating the effects of various moisture conditioning periods on permanent deformation (rutting) and fatigue damage of asphalt pavements. The constitutive and computational models are used to develop a framework for the simulation of the effect of moisture on the microstructural response of asphalt concrete. This framework explicitly incorporates the material microstructural distribution and properties. The developed framework is used to perform two-dimensional (2D) and three-dimensional (3D) micromechanical simulations in order to study and investigate the capability of the proposed constitutive relationships to predict the microstructural response of asphalt concrete under combined effect of moisture diffusion and mechanical loading. Advisors/Committee Members: Little, Dallas (advisor).

Subjects/Keywords: Moisture Damage

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Shakiba, M. (2013). A Continuum Coupled Moisture-mechanical Constitutive Model for Asphalt Concrete. (Thesis). Texas Digital Library. Retrieved from http://hdl.handle.net/1969; http://hdl.handle.net/2249.1/66856

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Shakiba, Maryam. “A Continuum Coupled Moisture-mechanical Constitutive Model for Asphalt Concrete.” 2013. Thesis, Texas Digital Library. Accessed February 22, 2020. http://hdl.handle.net/1969; http://hdl.handle.net/2249.1/66856.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Shakiba, Maryam. “A Continuum Coupled Moisture-mechanical Constitutive Model for Asphalt Concrete.” 2013. Web. 22 Feb 2020.

Vancouver:

Shakiba M. A Continuum Coupled Moisture-mechanical Constitutive Model for Asphalt Concrete. [Internet] [Thesis]. Texas Digital Library; 2013. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/1969; http://hdl.handle.net/2249.1/66856.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Shakiba M. A Continuum Coupled Moisture-mechanical Constitutive Model for Asphalt Concrete. [Thesis]. Texas Digital Library; 2013. Available from: http://hdl.handle.net/1969; http://hdl.handle.net/2249.1/66856

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Southern California

5. Jiang, Qingfei. Activation mechanism of damaged-induced DNA polymerase V in Escherichia coli.

Degree: PhD, Chemistry, 2009, University of Southern California

URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/272072/rec/496

► In Escherichia coli, cell survival and genomic stability after UV radiation depends on DNA repair mechanisms induced in response to DNA damage as part of… (more)

Subjects/Keywords: DNA damage

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Jiang, Q. (2009). Activation mechanism of damaged-induced DNA polymerase V in Escherichia coli. (Doctoral Dissertation). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/272072/rec/496

Chicago Manual of Style (16^th Edition):

Jiang, Qingfei. “Activation mechanism of damaged-induced DNA polymerase V in Escherichia coli.” 2009. Doctoral Dissertation, University of Southern California. Accessed February 22, 2020. http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/272072/rec/496.

MLA Handbook (7^th Edition):

Jiang, Qingfei. “Activation mechanism of damaged-induced DNA polymerase V in Escherichia coli.” 2009. Web. 22 Feb 2020.

Vancouver:

Jiang Q. Activation mechanism of damaged-induced DNA polymerase V in Escherichia coli. [Internet] [Doctoral dissertation]. University of Southern California; 2009. [cited 2020 Feb 22]. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/272072/rec/496.

Council of Science Editors:

Jiang Q. Activation mechanism of damaged-induced DNA polymerase V in Escherichia coli. [Doctoral Dissertation]. University of Southern California; 2009. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/272072/rec/496

Texas A&M University

6. Rady, Ayten Khaled Mohamed Abdelhalim. Formation Damage Due To Iron Precpitation In Limestone, Dolomite and Sandstone Cores.

Degree: MS, Petroleum Engineering, 2016, Texas A&M University

URL: http://hdl.handle.net/1969.1/157118

► Formation damage due to iron precipitation continues to be a major problem in the oil field. Research has established that as the pH of injected… (more)

Subjects/Keywords: iron formation damage

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rady, A. K. M. A. (2016). Formation Damage Due To Iron Precpitation In Limestone, Dolomite and Sandstone Cores. (Masters Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/157118

Chicago Manual of Style (16^th Edition):

Rady, Ayten Khaled Mohamed Abdelhalim. “Formation Damage Due To Iron Precpitation In Limestone, Dolomite and Sandstone Cores.” 2016. Masters Thesis, Texas A&M University. Accessed February 22, 2020. http://hdl.handle.net/1969.1/157118.

MLA Handbook (7^th Edition):

Rady, Ayten Khaled Mohamed Abdelhalim. “Formation Damage Due To Iron Precpitation In Limestone, Dolomite and Sandstone Cores.” 2016. Web. 22 Feb 2020.

Vancouver:

Rady AKMA. Formation Damage Due To Iron Precpitation In Limestone, Dolomite and Sandstone Cores. [Internet] [Masters thesis]. Texas A&M University; 2016. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/1969.1/157118.

Council of Science Editors:

Rady AKMA. Formation Damage Due To Iron Precpitation In Limestone, Dolomite and Sandstone Cores. [Masters Thesis]. Texas A&M University; 2016. Available from: http://hdl.handle.net/1969.1/157118

University of Alberta

7. Shivhare, Shishir. A study of the rheology, stability and pore blocking ability of non-aqueous colloidal gas aphron drilling fluids.

Degree: MS, Department of Civil and Environmental Engineering, 2011, University of Alberta

URL: https://era.library.ualberta.ca/files/2b88qc96d

► Colloidal gas aphrons (CGAs) recently used as part of water-based drilling fluids have been found effective in controlling the filtration rate by bridging the pores… (more)

Subjects/Keywords: aphron; formation damage

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Shivhare, S. (2011). A study of the rheology, stability and pore blocking ability of non-aqueous colloidal gas aphron drilling fluids. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/2b88qc96d

Chicago Manual of Style (16^th Edition):

Shivhare, Shishir. “A study of the rheology, stability and pore blocking ability of non-aqueous colloidal gas aphron drilling fluids.” 2011. Masters Thesis, University of Alberta. Accessed February 22, 2020. https://era.library.ualberta.ca/files/2b88qc96d.

MLA Handbook (7^th Edition):

Shivhare, Shishir. “A study of the rheology, stability and pore blocking ability of non-aqueous colloidal gas aphron drilling fluids.” 2011. Web. 22 Feb 2020.

Vancouver:

Shivhare S. A study of the rheology, stability and pore blocking ability of non-aqueous colloidal gas aphron drilling fluids. [Internet] [Masters thesis]. University of Alberta; 2011. [cited 2020 Feb 22]. Available from: https://era.library.ualberta.ca/files/2b88qc96d.

Council of Science Editors:

Shivhare S. A study of the rheology, stability and pore blocking ability of non-aqueous colloidal gas aphron drilling fluids. [Masters Thesis]. University of Alberta; 2011. Available from: https://era.library.ualberta.ca/files/2b88qc96d

Texas A&M University

8. Cui, Yan. Risk Assessment of Pipeline on Third-Party Damage in Oil and Gas Industry with Bayesian Network and Game Theory.

Degree: 2017, Texas A&M University

URL: http://hdl.handle.net/1969.1/161410

► Tremendous amount of oil and gas products are transported in pipeline worldwide giving rise to a demand to identify the hazards and evaluate the associated… (more)

Subjects/Keywords: Third-Party Damage

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cui, Y. (2017). Risk Assessment of Pipeline on Third-Party Damage in Oil and Gas Industry with Bayesian Network and Game Theory. (Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/161410

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Cui, Yan. “Risk Assessment of Pipeline on Third-Party Damage in Oil and Gas Industry with Bayesian Network and Game Theory.” 2017. Thesis, Texas A&M University. Accessed February 22, 2020. http://hdl.handle.net/1969.1/161410.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Cui, Yan. “Risk Assessment of Pipeline on Third-Party Damage in Oil and Gas Industry with Bayesian Network and Game Theory.” 2017. Web. 22 Feb 2020.

Vancouver:

Cui Y. Risk Assessment of Pipeline on Third-Party Damage in Oil and Gas Industry with Bayesian Network and Game Theory. [Internet] [Thesis]. Texas A&M University; 2017. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/1969.1/161410.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cui Y. Risk Assessment of Pipeline on Third-Party Damage in Oil and Gas Industry with Bayesian Network and Game Theory. [Thesis]. Texas A&M University; 2017. Available from: http://hdl.handle.net/1969.1/161410

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas A&M University

9. Ghorawat, Sandeep. Rapid Loss Modeling of Death and Downtime Caused By Earthquake Induced Damage to Structures.

Degree: 2012, Texas A&M University

URL: http://hdl.handle.net/1969.1/ETD-TAMU-2011-05-9072

► It is important to assess and communicate the risk to life and downtime associated with earthquake induced damage to structures. Thus, a previously developed four-diagram/four-step… (more)

Subjects/Keywords: Damage; Death; Downtime

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ghorawat, S. (2012). Rapid Loss Modeling of Death and Downtime Caused By Earthquake Induced Damage to Structures. (Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/ETD-TAMU-2011-05-9072

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ghorawat, Sandeep. “Rapid Loss Modeling of Death and Downtime Caused By Earthquake Induced Damage to Structures.” 2012. Thesis, Texas A&M University. Accessed February 22, 2020. http://hdl.handle.net/1969.1/ETD-TAMU-2011-05-9072.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ghorawat, Sandeep. “Rapid Loss Modeling of Death and Downtime Caused By Earthquake Induced Damage to Structures.” 2012. Web. 22 Feb 2020.

Vancouver:

Ghorawat S. Rapid Loss Modeling of Death and Downtime Caused By Earthquake Induced Damage to Structures. [Internet] [Thesis]. Texas A&M University; 2012. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2011-05-9072.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ghorawat S. Rapid Loss Modeling of Death and Downtime Caused By Earthquake Induced Damage to Structures. [Thesis]. Texas A&M University; 2012. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2011-05-9072

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas A&M University

10. Arastoo, Mahsa. Modeling Micro-Damage Healing Mechanism at Micro-Scale.

Degree: 2013, Texas A&M University

URL: http://hdl.handle.net/1969.1/151281

► This thesis demonstrates the effect of micro-damage healing on stress and displacement fields in the vicinity of a crack tip in the material that tend… (more)

▼ This thesis demonstrates the effect of micro-damage healing on stress and displacement fields in the vicinity of a crack tip in the material that tend to self-heal. The micro-damage healing model is modeled by incorporating time-dependent traction within the crack faces. This time-dependent traction occurs in a small zone referred to as healing process zone. The effect of the micro-damage healing on crack propagation in elastic media is investigated by deriving analytical relations for Stress Intensity Factor (SIF) when micro-damage healing mechanism is in effect. It is shown that the larger values of both healing process zone and bonding strength decrease the value of SIF near the crack tip. In order to clearly capture this phenomenon, a novel technique based on complex variables is used to derive the equations to calculate the stress and displacement fields in elastic media. Using the third correspondence principle, which is suitable in analyzing the crack shortening (healing phenomenon), the corresponding results of stress and displacement fields in elastic media are converted into viscoelastic media. Since asphalt has time-dependent material properties, the viscoelastic result is more accurate than the elastic. It is shown that an increase in the value of both healing process zone and bonding strength results in a decrease in the stress and displacement fields near the crack tip. Finally, the effect of using different coefficients in defining the bonding strength and relaxation time is evaluated. Asphalt concrete pavements are concurrently subjected to mechanical and environmental loading conditions during their service life. Applied mechanical and environmental loadings gradually degrade properties of asphalt concrete pavements. However, under specific conditions, asphalt concrete has the potential to heal and regain part of its strength. Identifying a model for the healing process is crucial. This proposed model is not dependent on the test methods that empower its usage in computational modeling. Moreover, this research considers both effects of instantaneous healing (a result of wetting) and time-dependent bond strength (a result of molecular diffusion between the crack faces), using the complex-variable method. Schapery (1989) considered only instantaneous healing and regarded it as the total bond strength. Therefore, considering both effects of instantaneous and time-dependent bond-strength makes this model superior with respect to the analogous model. It is hoped that this research provides insight on the healing mechanism at micro-scale. Advisors/Committee Members: Little, Dallas N. (advisor), Hueste, Mary Beth (committee member), Boas, Harold P. (committee member), Karaman, Ibrahim (committee member), Darabi, Masoud (committee member).

Subjects/Keywords: Micro damage healing

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Arastoo, M. (2013). Modeling Micro-Damage Healing Mechanism at Micro-Scale. (Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/151281

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Arastoo, Mahsa. “Modeling Micro-Damage Healing Mechanism at Micro-Scale.” 2013. Thesis, Texas A&M University. Accessed February 22, 2020. http://hdl.handle.net/1969.1/151281.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Arastoo, Mahsa. “Modeling Micro-Damage Healing Mechanism at Micro-Scale.” 2013. Web. 22 Feb 2020.

Vancouver:

Arastoo M. Modeling Micro-Damage Healing Mechanism at Micro-Scale. [Internet] [Thesis]. Texas A&M University; 2013. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/1969.1/151281.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Arastoo M. Modeling Micro-Damage Healing Mechanism at Micro-Scale. [Thesis]. Texas A&M University; 2013. Available from: http://hdl.handle.net/1969.1/151281

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Baylor University

11. [No author]. Damage accumulation of bovine bone under variable amplitude loads.

Degree: 2016, Baylor University

URL: http://hdl.handle.net/2104/9650

► Stress fractures, a painful injury, are caused by excessive fatigue in bone. This study into damage accumulation in bone sought to determine if the Palmgren-Miner… (more)

Subjects/Keywords: Bone. Fatigue. Damage.

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

author], [. (2016). Damage accumulation of bovine bone under variable amplitude loads. (Thesis). Baylor University. Retrieved from http://hdl.handle.net/2104/9650

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

author], [No. “Damage accumulation of bovine bone under variable amplitude loads. ” 2016. Thesis, Baylor University. Accessed February 22, 2020. http://hdl.handle.net/2104/9650.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

author], [No. “Damage accumulation of bovine bone under variable amplitude loads. ” 2016. Web. 22 Feb 2020.

Vancouver:

author] [. Damage accumulation of bovine bone under variable amplitude loads. [Internet] [Thesis]. Baylor University; 2016. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/2104/9650.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

author] [. Damage accumulation of bovine bone under variable amplitude loads. [Thesis]. Baylor University; 2016. Available from: http://hdl.handle.net/2104/9650

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Illinois – Urbana-Champaign

12. Shanley, IV, John Francis. In vitro simulation of torque-induced rotator cuff damage.

Degree: MS, Mechanical Engineering, 2018, University of Illinois – Urbana-Champaign

URL: http://hdl.handle.net/2142/101082

► Various aspects of rotator cuff tears have been studied in depth, including the primary pathogenesis and mechanical properties. There is, however, a lack of information… (more)

Subjects/Keywords: Rotator Cuff; Damage

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Shanley, IV, J. F. (2018). In vitro simulation of torque-induced rotator cuff damage. (Thesis). University of Illinois – Urbana-Champaign. Retrieved from http://hdl.handle.net/2142/101082

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Shanley, IV, John Francis. “In vitro simulation of torque-induced rotator cuff damage.” 2018. Thesis, University of Illinois – Urbana-Champaign. Accessed February 22, 2020. http://hdl.handle.net/2142/101082.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Shanley, IV, John Francis. “In vitro simulation of torque-induced rotator cuff damage.” 2018. Web. 22 Feb 2020.

Vancouver:

Shanley, IV JF. In vitro simulation of torque-induced rotator cuff damage. [Internet] [Thesis]. University of Illinois – Urbana-Champaign; 2018. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/2142/101082.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Shanley, IV JF. In vitro simulation of torque-induced rotator cuff damage. [Thesis]. University of Illinois – Urbana-Champaign; 2018. Available from: http://hdl.handle.net/2142/101082

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Penn State University

13. Matthews, Peter Joseph. Modeling Continuous-fiber Reinforced Polymer Composites for Exploration of Damage Tolerant Concepts.

Degree: PhD, Engineering Science and Mechanics, 2015, Penn State University

URL: https://etda.libraries.psu.edu/catalog/25002

► This work aims to improve the predictive capability for fiber-reinforced polymer matrix composite laminates using the finite element method. A new tool for modeling composite… (more)

Subjects/Keywords: composites; delamination; damage

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Matthews, P. J. (2015). Modeling Continuous-fiber Reinforced Polymer Composites for Exploration of Damage Tolerant Concepts. (Doctoral Dissertation). Penn State University. Retrieved from https://etda.libraries.psu.edu/catalog/25002

Chicago Manual of Style (16^th Edition):

Matthews, Peter Joseph. “Modeling Continuous-fiber Reinforced Polymer Composites for Exploration of Damage Tolerant Concepts.” 2015. Doctoral Dissertation, Penn State University. Accessed February 22, 2020. https://etda.libraries.psu.edu/catalog/25002.

MLA Handbook (7^th Edition):

Matthews, Peter Joseph. “Modeling Continuous-fiber Reinforced Polymer Composites for Exploration of Damage Tolerant Concepts.” 2015. Web. 22 Feb 2020.

Vancouver:

Matthews PJ. Modeling Continuous-fiber Reinforced Polymer Composites for Exploration of Damage Tolerant Concepts. [Internet] [Doctoral dissertation]. Penn State University; 2015. [cited 2020 Feb 22]. Available from: https://etda.libraries.psu.edu/catalog/25002.

Council of Science Editors:

Matthews PJ. Modeling Continuous-fiber Reinforced Polymer Composites for Exploration of Damage Tolerant Concepts. [Doctoral Dissertation]. Penn State University; 2015. Available from: https://etda.libraries.psu.edu/catalog/25002

University of Oxford

14. Baddock, Hannah. Understanding the role of the SNM1B and EXD2 in DNA damage repair.

Degree: PhD, 2017, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:e120ab1f-d001-4b9b-9a03-c0852f4dfd21 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.748895

► Unrepaired, or misrepaired, DNA damage can be carcinogenic or mutagenic; thus functional DNA damage repair pathways are essential for the safeguarding of the genome. SNM1B… (more)

Subjects/Keywords: DNA damage repair

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Baddock, H. (2017). Understanding the role of the SNM1B and EXD2 in DNA damage repair. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:e120ab1f-d001-4b9b-9a03-c0852f4dfd21 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.748895

Chicago Manual of Style (16^th Edition):

Baddock, Hannah. “Understanding the role of the SNM1B and EXD2 in DNA damage repair.” 2017. Doctoral Dissertation, University of Oxford. Accessed February 22, 2020. http://ora.ox.ac.uk/objects/uuid:e120ab1f-d001-4b9b-9a03-c0852f4dfd21 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.748895.

MLA Handbook (7^th Edition):

Baddock, Hannah. “Understanding the role of the SNM1B and EXD2 in DNA damage repair.” 2017. Web. 22 Feb 2020.

Vancouver:

Baddock H. Understanding the role of the SNM1B and EXD2 in DNA damage repair. [Internet] [Doctoral dissertation]. University of Oxford; 2017. [cited 2020 Feb 22]. Available from: http://ora.ox.ac.uk/objects/uuid:e120ab1f-d001-4b9b-9a03-c0852f4dfd21 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.748895.

Council of Science Editors:

Baddock H. Understanding the role of the SNM1B and EXD2 in DNA damage repair. [Doctoral Dissertation]. University of Oxford; 2017. Available from: http://ora.ox.ac.uk/objects/uuid:e120ab1f-d001-4b9b-9a03-c0852f4dfd21 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.748895

University of Adelaide

15. Nguyen, Thi Kim Phuong. Reservoir simulation studies of formation damage for improved recovery on oil-gas reservoirs.

Degree: 2011, University of Adelaide

URL: http://hdl.handle.net/2440/70889

► This thesis is dedicated to the development of new technologies for sweep improvement due to plugging of highly permeable channels and layers by injected or… (more)

▼ This thesis is dedicated to the development of new technologies for sweep improvement due to plugging of highly permeable channels and layers by injected or lifted or mobilized fines particles. The following methods of improved waterflood have been proposed in the thesis: • Injection of raw or poorly treated water with consequent homogenization of the injectivity profile due to distributed along the well skin factor. • Injection of low salinity or fresh water resulting in lifting of reservoir fines, their migration and further capture by the rock with permeability reduction and redirection of the injected water into unswept area. • Injection of sweet water into watered-up abandoned wells during pressure blowdown in oil and gas reservoirs with strong water support. In the above three cases, the proposal of the new technologies was backed by detailed reservoir simulations. In all cases, the application of the proposed improved oil recovery technology, as forecasted by reservoir simulation, leads to 3-15% of incremental recovery and 2-3 times decrease of the amount of produced and injected water. The technology of raw water injection was developed using Eclipse waterflood BlackOil simulator with modelling of injectivity decline along the well due to plugging of porous media by injected particles. A new numerical procedure describing skin growth with time in each section of long horizontal wells have been developed and implemented into BlackOil Eclipse model. Different configurations of horizontal injectors and producers have been modelled resulting in production forecast with raw waterflooding. The technology of low salinity water injection have been developed using Eclipse reservoir modelling with polymer injection option, which can describe mobilization of fines particles, their migration, capture and subsequent permeability decline. The main physics mechanism of incremental oil recovery found is the diversion of the injected water into unswept zones due to plugging the swept zone by capture particles. The incremental recovery, as obtained by reservoir simulation, is 12%. It may also result in 2 to 3 times decrease in water injection and production. The proposal of a new technology of small bank of fresh water injection into watered-up and abandoned production wells result in lifting of reservoir fines, their migration and plugging the path for invaded aquifer water. It results in decrease of water production and prolongation of oil or gas production from wells. Advisors/Committee Members: Bedrikovetski, Pavel (advisor), Haghighi, Manouchehr (advisor), Australian School of Petroleum (school).

Subjects/Keywords: simulations; formation damage

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Nguyen, T. K. P. (2011). Reservoir simulation studies of formation damage for improved recovery on oil-gas reservoirs. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/70889

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Nguyen, Thi Kim Phuong. “Reservoir simulation studies of formation damage for improved recovery on oil-gas reservoirs.” 2011. Thesis, University of Adelaide. Accessed February 22, 2020. http://hdl.handle.net/2440/70889.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Nguyen, Thi Kim Phuong. “Reservoir simulation studies of formation damage for improved recovery on oil-gas reservoirs.” 2011. Web. 22 Feb 2020.

Vancouver:

Nguyen TKP. Reservoir simulation studies of formation damage for improved recovery on oil-gas reservoirs. [Internet] [Thesis]. University of Adelaide; 2011. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/2440/70889.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Nguyen TKP. Reservoir simulation studies of formation damage for improved recovery on oil-gas reservoirs. [Thesis]. University of Adelaide; 2011. Available from: http://hdl.handle.net/2440/70889

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Central Connecticut State University

16. Orlinski, Agata W. (Agata Weronika), 1991-. A Prebiotic method toward mitigation of UVB-induced DNA damage, analyzed through CPD detection.

Degree: Department of Chemistry and Biochemistry, 2016, Central Connecticut State University

URL: http://content.library.ccsu.edu/u?/ccsutheses,2343

►

Research on the origin of biological life on Earth is actively working toward understanding the conditions under which possible prebiotic chemical reactions could promote abiogenesis.… (more)

▼

Research on the origin of biological life on Earth is actively working toward understanding the conditions under which possible prebiotic chemical reactions could promote abiogenesis. Cyclobutane pyrimidine dimer (CPD) is the main reaction product of UVB-induced photochemistry on DNA. The presence of a wall, behind which DNA is encapsulated, serves as a necessary boundary and energy exchange system between the interior of a cell and surrounding environment. It is presently undetermined how primitive genetic polymers were protected on early Earth, but naturally occurring molecules present >3.4 Ga ago may have had a role. At that age, the synthesis of organic monomers likely occurred at interfaces between energy and environment. The reducing atmosphere (electron rich) enabled molecules to gain electrons to transduce energy. Since modern membrane-bound molecules that contribute to the movement of electrons in photosynthesis - and have energy transducing properties - contain conjugated ring systems, (PAH) polycyclic aromatic hydrocarbons may have exerted a prebiotic role in redox chemistry. This work aimed to evaluate the effect of a cell model (a vesicle) containing a possible primitive chromophore (here, pyrene) on DNA mutagenesis. An immunochemical assay was used to detect CPDs, formed between adjacent thymine nucleobases on fragmented genomic DNA and induced by UVB light, when DNA was encapsulated in a membrane composed of phospholipid alone or phospholipid and pyrene. These simulations were compared to DNA not encapsulated in a membrane. Results demonstrate that higher overall detection of CPD-DNA correlates with a greater initial rate of CPD-DNA formation. Mainly, the largest rate corresponded to DNA in solution, while the slowest rate corresponded to DNA encapsulated within a (DOPy) DOPC + pyrene membrane.

"Submitted in Partial Fulfillment of the Requirements for the Degree of Master of Arts in Biomolecular Sciences."; Thesis advisor: Sarah E. Maurer.; M.A.,Central Connecticut State University,,2016.;

Advisors/Committee Members: Maurer, Sarah E..

Subjects/Keywords: DNA damage – Prevention.

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Orlinski, Agata W. (Agata Weronika), 1. (2016). A Prebiotic method toward mitigation of UVB-induced DNA damage, analyzed through CPD detection. (Thesis). Central Connecticut State University. Retrieved from http://content.library.ccsu.edu/u?/ccsutheses,2343

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Orlinski, Agata W. (Agata Weronika), 1991-. “A Prebiotic method toward mitigation of UVB-induced DNA damage, analyzed through CPD detection.” 2016. Thesis, Central Connecticut State University. Accessed February 22, 2020. http://content.library.ccsu.edu/u?/ccsutheses,2343.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Orlinski, Agata W. (Agata Weronika), 1991-. “A Prebiotic method toward mitigation of UVB-induced DNA damage, analyzed through CPD detection.” 2016. Web. 22 Feb 2020.

Vancouver:

Orlinski, Agata W. (Agata Weronika) 1. A Prebiotic method toward mitigation of UVB-induced DNA damage, analyzed through CPD detection. [Internet] [Thesis]. Central Connecticut State University; 2016. [cited 2020 Feb 22]. Available from: http://content.library.ccsu.edu/u?/ccsutheses,2343.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Orlinski, Agata W. (Agata Weronika) 1. A Prebiotic method toward mitigation of UVB-induced DNA damage, analyzed through CPD detection. [Thesis]. Central Connecticut State University; 2016. Available from: http://content.library.ccsu.edu/u?/ccsutheses,2343

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Rutgers University

17. Patel, Mihir V., 1987-. The roles of postsynaptic density-95 interactors in dendrite development and recovery after traumatic brain injury.

Degree: PhD, Neuroscience, 2018, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/59121/

►

Postsynaptic density 95 (PSD-95) is the major scaffolding protein at excitatory synapses, and it plays a major role in synaptic plasticity. Furthermore, PSD-95 and its… (more)

▼

Postsynaptic density 95 (PSD-95) is the major scaffolding protein at excitatory synapses, and it plays a major role in synaptic plasticity. Furthermore, PSD-95 and its interactor, cytosolic PSD-95 interactor (cypin), regulate dendrite branching by altering microtubule dynamics. Additionally, other PSD-95 binding proteins, end-binding protein 3 (EB3) and adenomatous polyposis coli (APC), promote microtubule bundling and stabilization. Thus, PSD-95 and binding partners may regulate the dendritic arbor during development and after injury. I first addressed the role of cypin in the brain in vivo. While generating cypin knockout mice, I identified a novel short isoform of cypin, termed cypinS, which also binds to PSD-95 and regulates dendrite branching, although an increase in dendrites occur more distal from the soma when cypinS is overexpressed compared to when cypin is overexpressed. In addition, unlike cypin, cypinS does not have guanine deaminase activity. Overexpression of cypin, but not cypinS, decreases spine density, suggestingiv that the regulation of spine density but not dendrite branching by cypin is dependent on guanine deaminase activity. Furthermore, I have uncovered novel presynaptic roles for both isoforms as overexpression of either isoform leads to increases in miniature excitatory postsynaptic current (mEPSC) frequency. Thus, cypin and cypinS, play distinct roles in neuronal development. I then chose to study the roles of PSD-95 and interactors in recovery after traumatic brain injury (TBI). We previously identified cypin as a novel target for TBI, and thus, here I studied the role of PSD-95 and its interaction with APC or EB3 in after injury induced by in vitro and in vivo models of TBI. I show that our in vitro model of mechanical stretch injury mimics moderate injury induced by controlled cortical impact (CCI) in mice. During the early stage (1-7 days) post-moderate CCI, the interaction of PSD-95 with APC and EB3 increases. Furthermore, downregulation of PSD-95 prevents stretch-injury mediated decreases in secondary dendrite number and total dendrite length, suggesting a required role of PSD-95 in injury-mediated insults to dendrites. Thus, PSD-95 may sequester APC and EB3 from microtubules to cause decreases in dendrite branching after TBI, and PSD-95 can be targeted as a novel approach for the treatment of patients with TBI.

Advisors/Committee Members: Firestein, Bonnie L (chair), Shumyatsky, Gleb (internal member), Alder, Janet (internal member), D’Arcangelo, Gabriella (internal member), Runnels, Loren (outside member), School of Graduate Studies.

Subjects/Keywords: Dendrites; Brain damage

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Patel, Mihir V., 1. (2018). The roles of postsynaptic density-95 interactors in dendrite development and recovery after traumatic brain injury. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/59121/

Chicago Manual of Style (16^th Edition):

Patel, Mihir V., 1987-. “The roles of postsynaptic density-95 interactors in dendrite development and recovery after traumatic brain injury.” 2018. Doctoral Dissertation, Rutgers University. Accessed February 22, 2020. https://rucore.libraries.rutgers.edu/rutgers-lib/59121/.

MLA Handbook (7^th Edition):

Patel, Mihir V., 1987-. “The roles of postsynaptic density-95 interactors in dendrite development and recovery after traumatic brain injury.” 2018. Web. 22 Feb 2020.

Vancouver:

Patel, Mihir V. 1. The roles of postsynaptic density-95 interactors in dendrite development and recovery after traumatic brain injury. [Internet] [Doctoral dissertation]. Rutgers University; 2018. [cited 2020 Feb 22]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/59121/.

Council of Science Editors:

Patel, Mihir V. 1. The roles of postsynaptic density-95 interactors in dendrite development and recovery after traumatic brain injury. [Doctoral Dissertation]. Rutgers University; 2018. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/59121/

University of Adelaide

18. Arjomand, Elaheh. Cement Sheath Integrity Assessment Subject to Pressure and Temperature Variations.

Degree: 2018, University of Adelaide

URL: http://hdl.handle.net/2440/120307

► The exploration and exploitation of hydrocarbon wells should not cause any environmental hazards including contamination of groundwater (aquifers) and atmosphere. The cement placed in the… (more)

▼ The exploration and exploitation of hydrocarbon wells should not cause any environmental hazards including contamination of groundwater (aquifers) and atmosphere. The cement placed in the annular gaps between the casing strings and the formation acts as a key barrier to provide zonal isolation and maintain the integrity of the wells. The integrity of the cement sheath and the cement sheath interfaces is susceptible to be compromised during well operational processes, including but not limited to, pressure integrity tests (PIT), completion operations, stimulation treatments, and production processes. The cement sheath may experience different types of mechanical damage as a result of being exposed to these different wellbore operational procedures. Therefore, understanding of cement failure mechanisms is of the utmost importance for better assessments of wellbore integrity. This thesis demonstrates the results of the experimental-numerical studies and investigates the integrity of the cement sheaths subjected to pressure and temperature variations. The overall purpose of this study is to improve the modelling capabilities of cement sheath integrity assessments by employing a more comprehensive constitutive model for the cement sheath compared to the rest of the models previously used. The experimental studies on the behaviour of the cement-based specimens under compression tests showed a strong non-linearity in the obtained stress-strain curves which confirms the necessity of applying plasticity theories. However, it is hard to explain the elastic stiffness degradation of the cement-based materials which happens during experiments using the classical plasticity theories. Therefore, in this thesis, the modified Concrete Damage Plasticity (CDP) model was employed, particularly formulated for modelling geo-materials such as rocks, concrete, and cementitious materials. The Concrete Damage Plasticity is a continuum model which combines plasticity and damage mechanisms, considering two different tensile and compressive state of damage. The yield criterion in the CDP model also represents the pressure-dependency of the geo-material behaviour under shearing at different levels of confinement in addition to the incorporation of non-associated flow rule (material dilatancy). These features show the superiority of the CDP model for employing in cement sheath integrity assessments. However, the paucity of cement class G mechanical parameters, e.g. lack of experimental data under different confining pressure and tensile properties, was an impediment to the incorporation of Concrete Damage Plasticity model. Therefore, the experimental aspect of this study intends to expand the cement class G inventory. The experimental data and analyses added to inventory are as followed. The investigations of curing temperature and pressure confinements effects on the strength and post-peak response of the cement class G under compression and also obtaining cement tensile properties. The experimental results show by increasing the curing… Advisors/Committee Members: School of Civil, Environmental and Mining Engineering (school).

Subjects/Keywords: Cement sheath integrity; concrete damage plasticity model; compression damage; tensile damage

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Arjomand, E. (2018). Cement Sheath Integrity Assessment Subject to Pressure and Temperature Variations. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/120307

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Arjomand, Elaheh. “Cement Sheath Integrity Assessment Subject to Pressure and Temperature Variations.” 2018. Thesis, University of Adelaide. Accessed February 22, 2020. http://hdl.handle.net/2440/120307.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Arjomand, Elaheh. “Cement Sheath Integrity Assessment Subject to Pressure and Temperature Variations.” 2018. Web. 22 Feb 2020.

Vancouver:

Arjomand E. Cement Sheath Integrity Assessment Subject to Pressure and Temperature Variations. [Internet] [Thesis]. University of Adelaide; 2018. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/2440/120307.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Arjomand E. Cement Sheath Integrity Assessment Subject to Pressure and Temperature Variations. [Thesis]. University of Adelaide; 2018. Available from: http://hdl.handle.net/2440/120307

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of New Mexico

19. Pelka, Sara M. Examination of color center formation in CaF2 crystals when exposed to gamma and mixed neutron/gamma fields.

Degree: Nuclear Engineering, 2017, University of New Mexico

URL: https://digitalrepository.unm.edu/ne_etds/61

► Color centers in CaF₂ were studied in this work, in parallel with examinations of changes in the refractive index of the crystals by the… (more)

Subjects/Keywords: color center; material damage; CaF2; neutron damage; gamma damage; F center; Nuclear Engineering

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pelka, S. M. (2017). Examination of color center formation in CaF2 crystals when exposed to gamma and mixed neutron/gamma fields. (Masters Thesis). University of New Mexico. Retrieved from https://digitalrepository.unm.edu/ne_etds/61

Chicago Manual of Style (16^th Edition):

Pelka, Sara M. “Examination of color center formation in CaF2 crystals when exposed to gamma and mixed neutron/gamma fields.” 2017. Masters Thesis, University of New Mexico. Accessed February 22, 2020. https://digitalrepository.unm.edu/ne_etds/61.

MLA Handbook (7^th Edition):

Pelka, Sara M. “Examination of color center formation in CaF2 crystals when exposed to gamma and mixed neutron/gamma fields.” 2017. Web. 22 Feb 2020.

Vancouver:

Pelka SM. Examination of color center formation in CaF2 crystals when exposed to gamma and mixed neutron/gamma fields. [Internet] [Masters thesis]. University of New Mexico; 2017. [cited 2020 Feb 22]. Available from: https://digitalrepository.unm.edu/ne_etds/61.

Council of Science Editors:

Pelka SM. Examination of color center formation in CaF2 crystals when exposed to gamma and mixed neutron/gamma fields. [Masters Thesis]. University of New Mexico; 2017. Available from: https://digitalrepository.unm.edu/ne_etds/61

University of Johannesburg

20. Capitani, Gina Maria. Longterm outcome after traumatic brain injury : neurological status and adjustment.

Degree: 2012, University of Johannesburg

URL: http://hdl.handle.net/10210/6892

►

D.Litt. et. Phil.

Head injury is the major cause of death for individuals under 35 years old in the United States of America, and a… (more)

▼

D.Litt. et. Phil.

Head injury is the major cause of death for individuals under 35 years old in the United States of America, and a similar picture exists in South Africa. A major cause of traumatic brain injury is motor vehicle accidents. In addition, the advances in modem medical technology increase the chances for survival, for example, sophisticated medical diagnostic techniques such as computerised tomography (CT), and magnetic resonance imaging (MRI). Advances in emergency trauma and neurosurgical procedures have also increased the number of survivors following a head injury. The symptoms resulting from head injury include disturbed physical, cognitive, psychological and behavioural functioning. Long-term management of these symptoms is usually required. A body of evidence exists that demonstrates the value of rehabilitation during the first year of recovery from traumatic brain injury. Head injury cases often result in litigation in that the injured person may be entitled to compensation for the injuries sustained. Considerable forensic debate exists around the issue of whether the victim's symptoms are attributable to organic brain damage, or whether they reflect a pre-existing functional psychological state of psychiatric illness, or personality disorder. Further still, the individual may be 'malingering' or faking postconcussion symptoms of headache, dizziness, fatigue, memory deficit, impaired concentration, irritability, anxiety, insomnia, concern about bodily functions, and hypersensitivity to light and noise. Alternatively, a common diagnosis is traumatic neurosis with a psychogenic basis, and in the context of litigation is referred to as "compensation neurosis". Specifically, the issue of contention revolves around concussion, and mild or minor head injuries. This study proposed that both neuropathophysiological and psychosocial symptoms occur in the event of a traumatic brain injury. This view supports the traditional model that pain or the sequelae of head injury are not affected by compensation. Therefore, the objective of the study was that follow-up assessment after compensation pay-outs should produce similar results to the assessment results obtained during the litigation process. The hypotheses of the study were essentially confirmed. The neuropsychological error scores produced in the assessments during litigation, and two-to-four years after the completion of litigation were similar. However, similar to other studies, variations were evident. Four exceptions were demonstrated in that significant improvement was evident with regard to shotterm verbal memory delayed recall for paragraphs, and for immediate recall (without and after interference) in verbal memory for a word list. These improvements therefore pertain to verbal memory. The fourth improvement occurred with respect to manual dexterity and visual-motor work speed, although the improvement may be peripheral or primary (neurological). Further findings included that no gender differences were evident in the neuropsychological…

Subjects/Keywords: Brain damage - Patients - Rehabilitation; Brain damage - Patients - Rehabilitation - Evaluation; Brain damage - Patients - Mental health; Neuropsychology

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Capitani, G. M. (2012). Longterm outcome after traumatic brain injury : neurological status and adjustment. (Thesis). University of Johannesburg. Retrieved from http://hdl.handle.net/10210/6892

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Capitani, Gina Maria. “Longterm outcome after traumatic brain injury : neurological status and adjustment.” 2012. Thesis, University of Johannesburg. Accessed February 22, 2020. http://hdl.handle.net/10210/6892.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Capitani, Gina Maria. “Longterm outcome after traumatic brain injury : neurological status and adjustment.” 2012. Web. 22 Feb 2020.

Vancouver:

Capitani GM. Longterm outcome after traumatic brain injury : neurological status and adjustment. [Internet] [Thesis]. University of Johannesburg; 2012. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/10210/6892.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Capitani GM. Longterm outcome after traumatic brain injury : neurological status and adjustment. [Thesis]. University of Johannesburg; 2012. Available from: http://hdl.handle.net/10210/6892

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Western Australia

21. Sha, Yanyan. Analysis, assessment and mitigation of barge impact load on bridge piers.

Degree: PhD, 2013, University of Western Australia

URL: http://repository.uwa.edu.au:80/R/?func=dbin-jump-full&object_id=34730&local_base=GEN01-INS01

►

[Truncated abstract] A growing number of large span bridges are built across navigable waterways all around the world in the past decades. These bridges are… (more)

▼

[Truncated abstract] A growing number of large span bridges are built across navigable waterways all around the world in the past decades. These bridges are under the threats of accidental impact loads generated by vehicles, winds and passing vessels. Among these accidents, vessel collisions are deemed to be an important issue as such accidents can result in bridge closure for inspection and repair before they are put into use again, cause severe casualties and huge financial losses. Therefore it is of vital importance to prevent and protect bridges from vessel impact damages. The primary objective of the study is to accurately quantify impact load and structural response of bridge piers subjected to barge impact. Empirical equations and simplified impact models are proposed for design practice. Methodologies for quick and reliable bridge condition assessment after barge impact, as well as impact damage mitigation techniques are also investigated in the study. In this research, barge impact loads on square and circular bridge piers are first investigated. Nonlinear finite element (FE) models that take into consideration nonlinear response and damage of both barge and pier structures are developed and calibrated with previous work and scaled impact tests. With the validated FE models, extensive numerical simulations are conducted to calculate barge impact force and pier response. Based on these simulation results, empirical equations are proposed to predict barge impact load as a function of barge velocity, barge mass and pier dimension and geometry. To simplify the analysis of bridge responses to barge impact, an equivalent nonlinear single degree of freedom (SDOF) system is proposed to predict pier responses to barge impact. The proposed SDOF model is validated with the 3D numerical simulations. The results show the proposed method can efficiently and accurately predict bridge responses to barge impact load and can be used in the design practice.

This proposed equivalent SDOF model analysis allows consideration of dynamic effects of bridge responses to barge impact. It bridges between the equivalent static analysis commonly used in the current design practice that neglects the dynamic effect of the barge-bridge interaction and the detailed finite element analysis commonly used in research that requires profound knowledge in structural dynamics, damage mechanics and computational mechanics, as well as enormous computational costs. In practice, it is also important to assess bridge conditions after a barge impact accident. In this study the feasibility of using vibration measurement under ambient condition to assess the condition of a three-span continuous girder bridge after a vessel impact accident is also explored. Bridge modal parameters are extracted from recorded bridge deck acceleration data under ambient hydrodynamics force by using the Frequency Domain Decomposition (FDD) method. The bridge conditions are identified by comparing the bridge modal parameters before and after barge impact. Occurrence of…

Subjects/Keywords: Barge impact; Pier damage; Pier response; Impact load; Damage mitigation; Damage identification; SDOF model

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sha, Y. (2013). Analysis, assessment and mitigation of barge impact load on bridge piers. (Doctoral Dissertation). University of Western Australia. Retrieved from http://repository.uwa.edu.au:80/R/?func=dbin-jump-full&object_id=34730&local_base=GEN01-INS01

Chicago Manual of Style (16^th Edition):

Sha, Yanyan. “Analysis, assessment and mitigation of barge impact load on bridge piers.” 2013. Doctoral Dissertation, University of Western Australia. Accessed February 22, 2020. http://repository.uwa.edu.au:80/R/?func=dbin-jump-full&object_id=34730&local_base=GEN01-INS01.

MLA Handbook (7^th Edition):

Sha, Yanyan. “Analysis, assessment and mitigation of barge impact load on bridge piers.” 2013. Web. 22 Feb 2020.

Vancouver:

Sha Y. Analysis, assessment and mitigation of barge impact load on bridge piers. [Internet] [Doctoral dissertation]. University of Western Australia; 2013. [cited 2020 Feb 22]. Available from: http://repository.uwa.edu.au:80/R/?func=dbin-jump-full&object_id=34730&local_base=GEN01-INS01.

Council of Science Editors:

Sha Y. Analysis, assessment and mitigation of barge impact load on bridge piers. [Doctoral Dissertation]. University of Western Australia; 2013. Available from: http://repository.uwa.edu.au:80/R/?func=dbin-jump-full&object_id=34730&local_base=GEN01-INS01

22. Xie, Xiaoyuan. Novel Players in Telomere Maintenance and Beyond.

Degree: 2017, Texas A&M University

URL: http://hdl.handle.net/1969.1/161433

► Telomeres are specialized nucleoprotein caps at the end of linear chromosomes, critical for genome stability. A major function of telomeres is to distinguish chromosome ends… (more)

▼ Telomeres are specialized nucleoprotein caps at the end of linear chromosomes, critical for genome stability. A major function of telomeres is to distinguish chromosome ends from ends of double strand breaks. A second function is to counteract incomplete end-replication via telomerase extension. POT1 (Protection of Telomere 1) is a highly conserved telomere protein known for its essential role in chromosome end-protection and end-replication. Arabidopsis thaliana encodes three POT1 paralogs, POT1a, POT1b, and POT1c. AtPOT1a promotes telomerase processivity and therefore is required for telomere length homeostasis. The functions of AtPOT1b and AtPOT1c are less understood. In this dissertation, I characterized the function of POT1b at telomeres. In contrast to POT1a, I found that POT1b is dispensable for telomere length maintenance and serves as a negative regulator of telomerase. In addition, I tested the hypothesis that TER2/POT1b works in concert with Ku to stabilize the blunt-ended telomeres. Further characterization of POT1b using biochemical and genetic approaches revealed several unexpected features. First, unlike POT1a, which is primarily localized to the nucleus, POT1b accumulates in the cytoplasm, where its binding partner TER2 also resides. This observation suggests a potential regulatory pathway for TER2 RNP via subcellular trafficking. In addition, I found that early development of POT1b mutants is significantly delayed, indicating that POT1b has a novel role in plant development. Together, these studies provide insights into the role of AtPOT1b in telomere biology and expand our understanding of POT1 protein function and evolution. In addition to these studies of POT1 proteins, I examined the role of chromosome remodeler DDM1 (Deficient in DNA Methylation 1) in telomere length maintenance. I showed that plants deficient in DDM1 suffer from abrupt telomere shortening in the sixth generation of the deficiency due to deletional recombination. This telomere rapid deletion (TRD) coincides with increased transposon activation and increased DNA damage sensitivity at the root apical meristem, suggesting that TRD may serve as a mechanism to stimulate programmed cell death, thereby eliminating stem cells with massive DNA damage. These studies open a new avenue for telomere function in promoting genome integrity. Advisors/Committee Members: Shippen, Dorothy (advisor), Rye, Hays (committee member), Shan, Libo (committee member), Bryk, Mary (committee member).

Subjects/Keywords: Telomeres; DNA damage; Epigenetics; Recombination

10 more images…

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Xie, X. (2017). Novel Players in Telomere Maintenance and Beyond. (Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/161433

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Xie, Xiaoyuan. “Novel Players in Telomere Maintenance and Beyond.” 2017. Thesis, Texas A&M University. Accessed February 22, 2020. http://hdl.handle.net/1969.1/161433.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Xie, Xiaoyuan. “Novel Players in Telomere Maintenance and Beyond.” 2017. Web. 22 Feb 2020.

Vancouver:

Xie X. Novel Players in Telomere Maintenance and Beyond. [Internet] [Thesis]. Texas A&M University; 2017. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/1969.1/161433.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Xie X. Novel Players in Telomere Maintenance and Beyond. [Thesis]. Texas A&M University; 2017. Available from: http://hdl.handle.net/1969.1/161433

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas A&M University

23. Marpaung, Fivman. Investigation of the effect of gel residue on hydraulic fracture conductivity using dynamic fracture conductivity test.

Degree: 2009, Texas A&M University

URL: http://hdl.handle.net/1969.1/ETD-TAMU-2102

► The key to producing gas from tight gas reservoirs is to create a long, highly conductive flow path, via the placement of a hydraulic fracture,… (more)

Subjects/Keywords: Gel Damage; Fracture Conductivity

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Marpaung, F. (2009). Investigation of the effect of gel residue on hydraulic fracture conductivity using dynamic fracture conductivity test. (Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/ETD-TAMU-2102

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Marpaung, Fivman. “Investigation of the effect of gel residue on hydraulic fracture conductivity using dynamic fracture conductivity test.” 2009. Thesis, Texas A&M University. Accessed February 22, 2020. http://hdl.handle.net/1969.1/ETD-TAMU-2102.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Marpaung, Fivman. “Investigation of the effect of gel residue on hydraulic fracture conductivity using dynamic fracture conductivity test.” 2009. Web. 22 Feb 2020.

Vancouver:

Marpaung F. Investigation of the effect of gel residue on hydraulic fracture conductivity using dynamic fracture conductivity test. [Internet] [Thesis]. Texas A&M University; 2009. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2102.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Marpaung F. Investigation of the effect of gel residue on hydraulic fracture conductivity using dynamic fracture conductivity test. [Thesis]. Texas A&M University; 2009. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2102

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas A&M University

24. Caro Spinel, Silvia. A Coupled Micromechanical Model of Moisture-Induced Damage in Asphalt Mixtures: Formulation and Applications.

Degree: 2011, Texas A&M University

URL: http://hdl.handle.net/1969.1/ETD-TAMU-2009-12-7336

► The deleterious effect of moisture on the structural integrity of asphalt mixtures has been recognized as one of the main causes of early deterioration of… (more)

▼ The deleterious effect of moisture on the structural integrity of asphalt mixtures has been recognized as one of the main causes of early deterioration of asphalt pavements. This phenomenon, usually referred to as moisture damage, is defined as the progressive loss of structural integrity of the mixture that is primarily caused by the presence of moisture in liquid or vapor state. Moisture damage is associated with the development of different physical, mechanical, and chemical processes occurring within the microstructure of the mixture at different intensities and rates. Although there have been important advancements in identifying and characterizing this phenomenon, there is still a lack of understanding of the damage mechanisms occurring at the microscopic level. This situation has motivated the research work reported in this dissertation. The main objective of this dissertation is to formulate and apply a numerical micromechanical model of moisture-induced damage in asphalt mixtures. The model focuses on coupling the effects of moisture diffusion?one of the three main modes of moisture transport within asphalt mixtures?with the mechanical performance of the microstructure. Specifically, the model aims to account for the effect of moisture diffusion on the degradation of the viscoelastic bulk matrix of the mixture (i.e., cohesive degradation) and on the gradual deterioration of the adhesive bonds between the aggregates and the asphalt matrix (i.e., adhesive degradation). The micromechanical model was applied to study the role of some physical and mechanical properties of the constitutive phases of the mixtures on the susceptibility of the mixture to moisture damage. The results from this analysis suggest that the diffusion coefficients of the asphalt matrix and aggregates, as well as the bond strength of the aggregate-matrix interface, have the most influence on the moisture susceptibility of the mixtures. The micromechanical model was further used to investigate the influence of the void phase of asphalt mixtures on the generation of moisture-related deterioration processes. Two different probabilistic-based approaches were used to accomplish this objective. In the first approach, a volumetric distribution of air voids sizes measured using X-Ray Computed Tomography in a dense-graded asphalt mixture was used to generate probable void structures in a microstructure of an asphalt mixture. In the second approach, a stochastic modeling technique based on random field theory was used to generate probable air voids distributions of the mixture. In this second approach, the influence of the air voids was accounted for by making the physical and mechanical properties of the asphalt matrix dependent on probable voids distributions. Although both approaches take into consideration the characteristics of the air void phase on the mechanical response of the mixtures subjected to moist environments, the former explicitly introduces the air phase within the microstructure while the latter indirectly includes its effects… Advisors/Committee Members: Masad, Eyad (advisor), Chen, Hamn-Ching (committee member), Little, Dallas (committee member), Lytton, Robert (committee member), Muliana, Anastasia (committee member), Scarpas, Athanasios (committee member).

Subjects/Keywords: Moisture damage; asphalt mixtures; micromechanics

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Caro Spinel, S. (2011). A Coupled Micromechanical Model of Moisture-Induced Damage in Asphalt Mixtures: Formulation and Applications. (Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/ETD-TAMU-2009-12-7336

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Caro Spinel, Silvia. “A Coupled Micromechanical Model of Moisture-Induced Damage in Asphalt Mixtures: Formulation and Applications.” 2011. Thesis, Texas A&M University. Accessed February 22, 2020. http://hdl.handle.net/1969.1/ETD-TAMU-2009-12-7336.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Caro Spinel, Silvia. “A Coupled Micromechanical Model of Moisture-Induced Damage in Asphalt Mixtures: Formulation and Applications.” 2011. Web. 22 Feb 2020.

Vancouver:

Caro Spinel S. A Coupled Micromechanical Model of Moisture-Induced Damage in Asphalt Mixtures: Formulation and Applications. [Internet] [Thesis]. Texas A&M University; 2011. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2009-12-7336.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Caro Spinel S. A Coupled Micromechanical Model of Moisture-Induced Damage in Asphalt Mixtures: Formulation and Applications. [Thesis]. Texas A&M University; 2011. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2009-12-7336

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas A&M University

25. Boltz, Kara A. Telomere Regulation in Arabidopsis thaliana by the CST Capping Complex and DNA Damage Response Proteins.

Degree: 2013, Texas A&M University

URL: http://hdl.handle.net/1969.1/151678

► The ends of chormosomes are capped by telomeres, which distinguish the termini from damaged DNA. Paradoxically, DNA repair proteins are also required for telomere maintenance.… (more)

▼ The ends of chormosomes are capped by telomeres, which distinguish the termini from damaged DNA. Paradoxically, DNA repair proteins are also required for telomere maintenance. How DNA repair pathways are regulated to maintain telomeres while remaining competent to repair DNA damage throughout the genome is unknown. In this dissertation, I used a genetic approach to investigate how critical components of telomerase and the telomere protein complex interact with the DNA damage response (DDR). In the flowering plant, Arabidopsis thaliana telomeres are bound by the CST (CTC1/STN1/TEN1) heterotrimer. Loss of any CST component results in telomere shortening, telomere fusions, increased G-overhang length and telomere recombination. To understand the phenotypes caused by CST deficiency, I examined telomeres from plants lacking CTC1 or STN1 and TERT or KU. My analysis showed that CST acts in a separate genetic pathway for telomere length regulation from both KU and TERT. Further, I found that KU and CST act in separate genetic pathways for regulation of G-overhang formation. These demonstrate that multiple pathways are used to maintain telomere length and architecture in plants. My study of the interaction of telomere components with the DDR revealed ATR promotes genome stability and telomere length maintenance in the absence of CTC1, probably by activating programmed cell death of stem cells with high amounts of DNA damage. I also found that poly(ADP-ribosylation) is not required for maintenance of Arabidopsis telomeres, in contrast to human telomeres. Finally, I found an unexpected connection between the DDR and telomerase. My research showed that ATR maintains telomerase activity levels. Further, induction of double- stranded DNA breaks in seedlings led to a rapid decrease in telomerase activity, which correlated with increased abundance of TER2, an alternate Arabidopsis telomerase RNA. I hypothesize that TER2 inhibits telomerase to prevent its inappropriate action at internal sites in chromosomes. These data reveal two ways that DDR pathways work in concert with telomerase to promote genome integrity. Advisors/Committee Members: Shippen, Dorothy E (advisor), McKnight, Thomas (advisor), Versaw, Wayne (committee member), Peterson, David O (committee member).

Subjects/Keywords: Telomeres; Telomerase; DNA damage; CST

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Boltz, K. A. (2013). Telomere Regulation in Arabidopsis thaliana by the CST Capping Complex and DNA Damage Response Proteins. (Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/151678

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Boltz, Kara A. “Telomere Regulation in Arabidopsis thaliana by the CST Capping Complex and DNA Damage Response Proteins.” 2013. Thesis, Texas A&M University. Accessed February 22, 2020. http://hdl.handle.net/1969.1/151678.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Boltz, Kara A. “Telomere Regulation in Arabidopsis thaliana by the CST Capping Complex and DNA Damage Response Proteins.” 2013. Web. 22 Feb 2020.

Vancouver:

Boltz KA. Telomere Regulation in Arabidopsis thaliana by the CST Capping Complex and DNA Damage Response Proteins. [Internet] [Thesis]. Texas A&M University; 2013. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/1969.1/151678.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Boltz KA. Telomere Regulation in Arabidopsis thaliana by the CST Capping Complex and DNA Damage Response Proteins. [Thesis]. Texas A&M University; 2013. Available from: http://hdl.handle.net/1969.1/151678

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Victoria University of Wellington

26. Carson, Georgia. The Two Faces of Ascorbate: Prooxidant Activity and Radio-Sensitisation.

Degree: 2016, Victoria University of Wellington

URL: http://hdl.handle.net/10063/5196

► Although not recommended by mainstream oncologists, intravenous injections of pharmacological ascorbate are currently an alternative therapy option for cancer patients. Research has not yet determined… (more)

▼ Although not recommended by mainstream oncologists, intravenous injections of pharmacological ascorbate are currently an alternative therapy option for cancer patients. Research has not yet determined whether high-dose ascorbate interacts favourably with radiation therapy to increase DNA damage, and therefore cell death in cancer. Some studies suggest that ascorbate can act as a prooxidant and increase the cytotoxic effect of irradiation in vitro. Glioblastoma multiforme (GBM) is a primary brain astrocytoma that is highly therapy resistant, so patients would be advantaged if ascorbate radiosensitised their cancer. In this investigation, flow cytometry and single cell gel electrophoresis (comet tail assay) were used to measure three indicators of DNA damage in GBM cells in response to ascorbate and irradiation, and were contrasted with immunofluorescence-revealed DNA damage from an intracranial mouse model of GBM. The pro-oxidant, radiosensitisation role of ascorbate was confirmed, as measured by H2AX, 8OHdG, and DSBs in vitro. With all three of these markers of DNA damage, combinations of irradiation and ascorbate had increased damage compared with individual treatments. However preliminary in vivo evidence indicates that increased DNA damage did not occur in an animal model of GBM, and in fact ascorbate may protect from DNA damage in an in vivo context. These findings complement previous results from our lab, and serve to fill in gaps in knowledge specifically around the DNA damaging effects of ascorbate. The unique nature of the brain environment, as enclosed by the blood brain barrier, prevents translation of data from other non-brain cancer studies, as such, this investigation also contributes to the exploration of a much needed avenue of research. Considering the context of ascorbate treatment as a potentially harmful currently used adjuvant, it is imperative to confirm or disprove its efficacy in a clinically relevant environment. Advisors/Committee Members: McConnell, Melanie.

Subjects/Keywords: Glioblastoma; Ascorbate; DNA damage

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Carson, G. (2016). The Two Faces of Ascorbate: Prooxidant Activity and Radio-Sensitisation. (Masters Thesis). Victoria University of Wellington. Retrieved from http://hdl.handle.net/10063/5196

Chicago Manual of Style (16^th Edition):

Carson, Georgia. “The Two Faces of Ascorbate: Prooxidant Activity and Radio-Sensitisation.” 2016. Masters Thesis, Victoria University of Wellington. Accessed February 22, 2020. http://hdl.handle.net/10063/5196.

MLA Handbook (7^th Edition):

Carson, Georgia. “The Two Faces of Ascorbate: Prooxidant Activity and Radio-Sensitisation.” 2016. Web. 22 Feb 2020.

Vancouver:

Carson G. The Two Faces of Ascorbate: Prooxidant Activity and Radio-Sensitisation. [Internet] [Masters thesis]. Victoria University of Wellington; 2016. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/10063/5196.

Council of Science Editors:

Carson G. The Two Faces of Ascorbate: Prooxidant Activity and Radio-Sensitisation. [Masters Thesis]. Victoria University of Wellington; 2016. Available from: http://hdl.handle.net/10063/5196

University of Hong Kong

27. Yang, Sitian. Novel role of drug-induced non homologous end joining factor 1 in the chemoresistance of hepatocellular carcinoma.

Degree: PhD, 2015, University of Hong Kong

URL: Yang, S. [楊斯恬]. (2015). Novel role of drug-induced non homologous end joining factor 1 in the chemoresistance of hepatocellular carcinoma. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5435663 ; http://dx.doi.org/10.5353/th_b5435663 ; http://hdl.handle.net/10722/224076

► Hepatocellular carcinoma (HCC) is highly resistant to chemotherapy and one of the most common causes of cancer related death worldwide. Chemoresistance in HCC leads to… (more)

▼ Hepatocellular carcinoma (HCC) is highly resistant to chemotherapy and one of the most common causes of cancer related death worldwide. Chemoresistance in HCC leads to restricted treatment option and poor prognosis. Acquired cellular chemoresistance mechanisms include oncogenes mutation, multi-drug resistance gene (MDR1) over expression or hypermethylation, cancer stem cells enrichment, and dysfunctional apoptosis. Most cytotoxic drugs serve as DNA damaging agents and are able to generate various DNA damages among which double strand breaks (DSBs) are the most toxic. Cellular responses such as increased DNA damage repair might imply a potential chemoresistance, which is not well defined in HCC. In this project, I aim to identify potential role of NHEJ1 mediated non homologous end joining (NHEJ) repair in HCC chemoresistance. Chemo-drugs with diverse damaging effects (cisplatin/oxaliplatin: bulky adducts and cross link; doxorubicin: single strand breaks; 5-Fu: mismatch bases) can induce DSBs in HCC cells. In response, expressions of the key genes involved in NHEJ pathway were significantly increased. By calculating chemo-drugs IC50 concentration, we found that IC50 of HCC line 97L was significantly higher than PLC cells. Using the plasmid-based cell-free and live cell NHEJ assay, 97L cells displayed significantly enhanced NHEJ activity in both in vitro and in vivo assay, whereas PLC cell did not show drug-induced NHEJ activity. In addition, chemo drug-induced NHEJ activity was significantly increased in CD133+ HCC cell (known as HCC cancer stem cell proportion) but not in their CD133- counterparts, resulting in a more chemoresistance in CD133+ cell. These data indicate that efficient NHEJ repair might involve in chemo-resistance in HCC cells. Non homologous end joining factor 1 (NHEJ1) is a novel component of the NHEJ pathway. NHEJ1 interacts with XRCC4 and stabilize LIG4/XRCC4/NHEJ1 complex during DSBs ends ligation—the final step of the NHEJ pathway. Based on integrative analysis of cancer genomics and clinical profiles, low genomic alteration frequency of NHEJ1 was found in many types of cancers including in HCC (0.5%). However, in my clinical study, significantly enhanced NHEJ1 expressions were found in HCC patients who received transcatheter arterial chemoembolization (TACE) but not in patients without TACE or any chemo-drug treatment, indicating a responsive over expression of NHEJ1 after chemo-drug treatment. More importantly, higher expression of NHEJ1 in TACE patients was significantly associated with larger tumor size, presence of venous infiltration, advanced stage and shorter overall survival. Silencing NHEJ1 by siRNA or shRNA inhibited drug-induced NHEJ activity therefore restored chemo-drug sensitivity in 97L cells. The sensitive effects were shown by suppressed colony formation in vitro, and reduction of HCC tumor size in vivo using a xenograft mouse model. I also found that there was a cosuppression of LIG4 and ERCC1 in shNHEJ1 cells. Furthermore, co-inhibition of NHEJ1 and ERCC1 by siRNA…

Subjects/Keywords: Liver - Cancer - Chemotherapy; DNA damage

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Yang, S. (2015). Novel role of drug-induced non homologous end joining factor 1 in the chemoresistance of hepatocellular carcinoma. (Doctoral Dissertation). University of Hong Kong. Retrieved from Yang, S. [楊斯恬]. (2015). Novel role of drug-induced non homologous end joining factor 1 in the chemoresistance of hepatocellular carcinoma. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5435663 ; http://dx.doi.org/10.5353/th_b5435663 ; http://hdl.handle.net/10722/224076

Chicago Manual of Style (16^th Edition):

Yang, Sitian. “Novel role of drug-induced non homologous end joining factor 1 in the chemoresistance of hepatocellular carcinoma.” 2015. Doctoral Dissertation, University of Hong Kong. Accessed February 22, 2020. Yang, S. [楊斯恬]. (2015). Novel role of drug-induced non homologous end joining factor 1 in the chemoresistance of hepatocellular carcinoma. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5435663 ; http://dx.doi.org/10.5353/th_b5435663 ; http://hdl.handle.net/10722/224076.

MLA Handbook (7^th Edition):

Yang, Sitian. “Novel role of drug-induced non homologous end joining factor 1 in the chemoresistance of hepatocellular carcinoma.” 2015. Web. 22 Feb 2020.

Vancouver:

Yang S. Novel role of drug-induced non homologous end joining factor 1 in the chemoresistance of hepatocellular carcinoma. [Internet] [Doctoral dissertation]. University of Hong Kong; 2015. [cited 2020 Feb 22]. Available from: Yang, S. [楊斯恬]. (2015). Novel role of drug-induced non homologous end joining factor 1 in the chemoresistance of hepatocellular carcinoma. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5435663 ; http://dx.doi.org/10.5353/th_b5435663 ; http://hdl.handle.net/10722/224076.

Council of Science Editors:

Yang S. Novel role of drug-induced non homologous end joining factor 1 in the chemoresistance of hepatocellular carcinoma. [Doctoral Dissertation]. University of Hong Kong; 2015. Available from: Yang, S. [楊斯恬]. (2015). Novel role of drug-induced non homologous end joining factor 1 in the chemoresistance of hepatocellular carcinoma. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5435663 ; http://dx.doi.org/10.5353/th_b5435663 ; http://hdl.handle.net/10722/224076

University of Hawaii

28. Armstrong-Cassidy, Amanda S. Effect of neurotraining on the cognitive rehabilitation of brain damage or dysfunction : an initial analysis.

Degree: PhD, 2009, University of Hawaii

URL: http://hdl.handle.net/10125/10195

►

Typescript.

Bibliography: leaves 199-213.

Photocopy.

xi, 213 leaves, bound ill. 29 cm

A quasi-experimental evaluation of the effects of neurotraining (as a broad spectrum approach… (more)

Subjects/Keywords: Brain damage – Patients – Rehabilitation

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Armstrong-Cassidy, A. S. (2009). Effect of neurotraining on the cognitive rehabilitation of brain damage or dysfunction : an initial analysis. (Doctoral Dissertation). University of Hawaii. Retrieved from http://hdl.handle.net/10125/10195

Chicago Manual of Style (16^th Edition):

Armstrong-Cassidy, Amanda S. “Effect of neurotraining on the cognitive rehabilitation of brain damage or dysfunction : an initial analysis.” 2009. Doctoral Dissertation, University of Hawaii. Accessed February 22, 2020. http://hdl.handle.net/10125/10195.

MLA Handbook (7^th Edition):

Armstrong-Cassidy, Amanda S. “Effect of neurotraining on the cognitive rehabilitation of brain damage or dysfunction : an initial analysis.” 2009. Web. 22 Feb 2020.

Vancouver:

Armstrong-Cassidy AS. Effect of neurotraining on the cognitive rehabilitation of brain damage or dysfunction : an initial analysis. [Internet] [Doctoral dissertation]. University of Hawaii; 2009. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/10125/10195.

Council of Science Editors:

Armstrong-Cassidy AS. Effect of neurotraining on the cognitive rehabilitation of brain damage or dysfunction : an initial analysis. [Doctoral Dissertation]. University of Hawaii; 2009. Available from: http://hdl.handle.net/10125/10195

University of Tasmania

29. Little, Jason Stuart. Change in electrophysiological correlates of recognition memory processes following mild traumatic brain injury.

Degree: 2010, University of Tasmania

URL: https://eprints.utas.edu.au/20758/1/whole_LittleJasonStuart2010_thesis.pdf

► There is a considerable body of evidence showing the presence of long term change in electrophysiological correlates of attentional processes following mild traumatic brain injury… (more)

▼ There is a considerable body of evidence showing the presence of long term change in electrophysiological correlates of attentional processes following mild traumatic brain injury (MTBI). As well there is a large body of research demonstrating impairment in cognitive functioning, including memory and attention processes, in the acute stage following MTBI. However, to date there has been little research investigating long term change in electrophysiological correlates of memory function following MTBI. More specifically, there is virtually no research investigating long term change in electrophysiological correlates of recognition memory function following MTBI. Therefore the present research aimed to investigate the electrophysiological correlates of recognition memory processes in males who had suffered an MTI3I. Event related potentials (ERPs) were collected during the encoding phases and the recognition phases from three recognition memory paradigm experiments. In Experiment 1, 22 males who experienced an MTBI 1 month prior, 21 males who experienced an MTBI 24 months prior, and 19 control group males completed two recognition memory tasks, one under deep and one under shallow Level-of-processing conditions, using low frequency nouns as stimuli. ERP data from the deep Level-of-processing encoding phase showed that the expected subsequent memory effect of greater mean amplitude (500-800ms) for subsequently remembered than subsequently missed studied words was present for the control group and the 24 month MTBI group, yet absent for the 1 month MTBI group. Recognition phase data showed that neither MTBI group displayed the implicit memory effect of greater mean amplitude (300-500ms) parietally for missed old words compared to unstudied words under shallow Level-of-processing conditions, whereas the control group did. Experiment 2 employed the same experimental paradigm as Experiment 1 and involved MTBI participants from both MTBI groups from Experiment 1. Fifteen participants from the 1 month MTBI group completed the experimental tasks at approximately 7 month following Experiment 1 (labelled 'Time 2'), and 12 of these participants completed the experimental task a third occasion after a further 10 months (labelled 'Time 3'). Sixteen participants from the 24 month MTBI group completed the same experimental task approximately 13 months after Experiment 1 (labelled 'Time 2'). The results from the encoding phase of Experiment 2 showed that the 1 month MTBI group displayed a subsequent memory effect at Time 2. However, at Time 3 for the 1 month MTBI group and at Time 2 for the 24 month MTBI group, no subsequent memory effects were present due to an apparent increase in mean amplitude elicited by subsequently missed old words. These results suggest that there may be impairment or change in processes involved in encoding meaningful information which, over months and years following the acute post-injury phase, may lead to adaption in these processes. Within recognition phase data results from both MTBI groups showed an…

Subjects/Keywords: Brain; Brain damage; Cognitive psychology

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Little, J. S. (2010). Change in electrophysiological correlates of recognition memory processes following mild traumatic brain injury. (Thesis). University of Tasmania. Retrieved from https://eprints.utas.edu.au/20758/1/whole_LittleJasonStuart2010_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Little, Jason Stuart. “Change in electrophysiological correlates of recognition memory processes following mild traumatic brain injury.” 2010. Thesis, University of Tasmania. Accessed February 22, 2020. https://eprints.utas.edu.au/20758/1/whole_LittleJasonStuart2010_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Little, Jason Stuart. “Change in electrophysiological correlates of recognition memory processes following mild traumatic brain injury.” 2010. Web. 22 Feb 2020.

Vancouver:

Little JS. Change in electrophysiological correlates of recognition memory processes following mild traumatic brain injury. [Internet] [Thesis]. University of Tasmania; 2010. [cited 2020 Feb 22]. Available from: https://eprints.utas.edu.au/20758/1/whole_LittleJasonStuart2010_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Little JS. Change in electrophysiological correlates of recognition memory processes following mild traumatic brain injury. [Thesis]. University of Tasmania; 2010. Available from: https://eprints.utas.edu.au/20758/1/whole_LittleJasonStuart2010_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Hong Kong

30. 阮嘉駿.; Un, Ka-chun. Effects of dexamethasone and progesterone treatment on experimental brain injury induced by surgical electrocautery.

Degree: Master of Research in Medicine, Medicine, 2012, University of Hong Kong

URL: Un, K. [阮嘉駿]. (2012). Effects of dexamethasone and progesterone treatment on experimental brain injury induced by surgical electrocautery. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4833480 ; http://dx.doi.org/10.5353/th_b4833480 ; http://hdl.handle.net/10722/174265

►

Haemostasis is an important aspect in neurosurgical operations for the achievement of good outcome. Bipolar coagulation is an extensively used haemostatic technique in modern neurosurgery… (more)

▼

Haemostasis is an important aspect in neurosurgical operations for the achievement of good outcome. Bipolar coagulation is an extensively used haemostatic technique in modern neurosurgery but it may also cause iatrogenic brain trauma due to thermal injury. Published studies on coagulation-induced brain injury on a histological level are, however, limited. The present study aimed at investigating the extent of inflammatory and glial responses caused by different settings of bipolar coagulation using an animal model. It also investigated whether and how pre-operative treatment with dexamethasone or progesterone, both known to have neuro-protective effects, would modulate gliosis and macrophage infiltration induced by bipolar coagulation. The study consisted of two parts. The first part investigated the astrocytic and macrophage responses after bipolar coagulation at different power settings. 45 Sprague-Dawley rats received craniotomy, followed by bipolar coagulation at different power output settings (mock operation as control, 20W and 40W) over the rat cortex for a standardized duration of two seconds. On day 3, day 7 and day 28, brain sections were assessed by immunohistochemical staining for GFAP (astrocytes) and ED1 (macrophages). Quantification of outcome by random field cell counting under light microscopy was performed. The second part of the study used another 45 male Sprague-Dawley rats, divided into three treatment groups: Group 1 received the vehicle agents only (Control); Group 2 received progesterone 20mg/kg; Group 3 received dexamethasone 1 mg/kg. All treatments were given intraperitoneally two hours before craniotomy. The animals received bipolar coagulation at 40W for a standardized duration of two seconds. On day 1, 3 and 7, brain sections were assessed by immunohistochemical staining for GFAP and ED1. Quantification of outcome by random field cell counting under light microscopy was performed. T2-weighted magnetic resonance imaging for the animals on day 3 was also performed. The results showed that bipolar coagulation was associated with significant glial and inflammatory responses that correlated with power output. Progesterone and dexamethasone were both effective in reducing the glial hypertrophy and macrophage infiltration associated with bipolar coagulation. Dexamethasone had an additional advantage of reducing brain oedema and cavity formation. The findings suggested that progesterone and dexamethasone could be further explored as potential protective and/or remedial agents for bipolar coagulation-induced brain trauma sustained during neurosurgical procedures.

published_or_final_version

Surgery

Master

Master of Research in Medicine

Subjects/Keywords: Glucocorticoids.; Progesterone.; Brain damage - Prevention.

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

阮嘉駿.; Un, K. (2012). Effects of dexamethasone and progesterone treatment on experimental brain injury induced by surgical electrocautery. (Masters Thesis). University of Hong Kong. Retrieved from Un, K. [阮嘉駿]. (2012). Effects of dexamethasone and progesterone treatment on experimental brain injury induced by surgical electrocautery. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4833480 ; http://dx.doi.org/10.5353/th_b4833480 ; http://hdl.handle.net/10722/174265

Chicago Manual of Style (16^th Edition):

阮嘉駿.; Un, Ka-chun. “Effects of dexamethasone and progesterone treatment on experimental brain injury induced by surgical electrocautery.” 2012. Masters Thesis, University of Hong Kong. Accessed February 22, 2020. Un, K. [阮嘉駿]. (2012). Effects of dexamethasone and progesterone treatment on experimental brain injury induced by surgical electrocautery. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4833480 ; http://dx.doi.org/10.5353/th_b4833480 ; http://hdl.handle.net/10722/174265.

MLA Handbook (7^th Edition):

阮嘉駿.; Un, Ka-chun. “Effects of dexamethasone and progesterone treatment on experimental brain injury induced by surgical electrocautery.” 2012. Web. 22 Feb 2020.

Vancouver:

阮嘉駿.; Un K. Effects of dexamethasone and progesterone treatment on experimental brain injury induced by surgical electrocautery. [Internet] [Masters thesis]. University of Hong Kong; 2012. [cited 2020 Feb 22]. Available from: Un, K. [阮嘉駿]. (2012). Effects of dexamethasone and progesterone treatment on experimental brain injury induced by surgical electrocautery. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4833480 ; http://dx.doi.org/10.5353/th_b4833480 ; http://hdl.handle.net/10722/174265.

Council of Science Editors:

阮嘉駿.; Un K. Effects of dexamethasone and progesterone treatment on experimental brain injury induced by surgical electrocautery. [Masters Thesis]. University of Hong Kong; 2012. Available from: Un, K. [阮嘉駿]. (2012). Effects of dexamethasone and progesterone treatment on experimental brain injury induced by surgical electrocautery. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4833480 ; http://dx.doi.org/10.5353/th_b4833480 ; http://hdl.handle.net/10722/174265

		in
And / Or
		in
And / Or
		in
And / Or
		in

Open Access Theses and Dissertations