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You searched for subject:(d delta tocotrienol). Showing records 1 – 3 of 3 total matches.

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Georgia State University

1. Sharma, Shaligram. EFFECTS OF D-DELTA TOCOTRIENOL ON HIGH-FAT DIET-INDUCED PERIPHERAL INFLAMMATION.

Degree: MS, Biology, 2017, Georgia State University

Little is known about the ability of d-δ-tocotrienol to protect against obesity-induced inflammation. These studies were conducted to determine whether d-δ-tocotrienol inhibits highfat diet (HFD)-induced peripheral inflammation, and to explore potential mechanisms by which d-δ-tocotrienol affects inflammation. In two animal experiments, mice were fed a low-fat control diet, a high-fat control diet, or a HFD supplemented with d-δ-tocotrienol: 400 mg/kg diet (experiment1) or 60 mg/kg body weight (experiment #2) for 14 weeks. Expression of inflammatory and anti-inflammatory markers was measured in liver and white adipose tissue, and phosphorylation of STAT3 was measured using western blot. d-δ-tocotrienol mitigate HFDinduced hepatic inflammation, despite having no effect on body weight, suggesting direct antiinflammatory effects of d-δ-tocotrienol independent of body weight loss. Mechanistic studies in 3T3-L1 adipocytes indicated that d-δ-tocotrienol suppresses LPS-induced inflammation through down-regulating STAT3 signaling. The potential for d-δ-tocotrienol as a treatment of obesity and related metabolic diseases requires further investigation. Advisors/Committee Members: Desiree Wanders, Huanbiao Mo, Hang Shi.

Subjects/Keywords: d-δ-tocotrienol; Anti-inflammatory; Signal Transducer and Activator of Transcription (STAT3)

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APA (6th Edition):

Sharma, S. (2017). EFFECTS OF D-DELTA TOCOTRIENOL ON HIGH-FAT DIET-INDUCED PERIPHERAL INFLAMMATION. (Thesis). Georgia State University. Retrieved from https://scholarworks.gsu.edu/biology_theses/79

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Sharma, Shaligram. “EFFECTS OF D-DELTA TOCOTRIENOL ON HIGH-FAT DIET-INDUCED PERIPHERAL INFLAMMATION.” 2017. Thesis, Georgia State University. Accessed October 25, 2020. https://scholarworks.gsu.edu/biology_theses/79.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Sharma, Shaligram. “EFFECTS OF D-DELTA TOCOTRIENOL ON HIGH-FAT DIET-INDUCED PERIPHERAL INFLAMMATION.” 2017. Web. 25 Oct 2020.

Vancouver:

Sharma S. EFFECTS OF D-DELTA TOCOTRIENOL ON HIGH-FAT DIET-INDUCED PERIPHERAL INFLAMMATION. [Internet] [Thesis]. Georgia State University; 2017. [cited 2020 Oct 25]. Available from: https://scholarworks.gsu.edu/biology_theses/79.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sharma S. EFFECTS OF D-DELTA TOCOTRIENOL ON HIGH-FAT DIET-INDUCED PERIPHERAL INFLAMMATION. [Thesis]. Georgia State University; 2017. Available from: https://scholarworks.gsu.edu/biology_theses/79

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

2. Fernandes, Nicolle Valerie. Impact of delta-tocotrienol on human melanoma cell proliferation.

Degree: PhD, Nutrition, 2010, Texas Woman's University

The rate-limiting enzyme of the mevalonate pathway, 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, provides essential intermediates for the prenylation or dolichylation of growth-related proteins including nuclear Ras, nuclear lamins, and growth factor receptors. d-δ-tocotrienol, a post-transcriptional down-regulator of HMG CoA reductase, suppresses the proliferation of marine B16 melanoma cells and human blood, breast, cervix, colon, liver, lung, lymph gland, nerve, pancreas, and prostate tumor cells. Dietary d-δ-tocotrienol suppresses the growth of implanted B16 melanomas without toxicity to host mice. We evaluated the impact of d-δ-tocotrienol on the proliferation of human A2058 and A375 melanoma cells. d-δ-tocotrienol induced dose-dependent suppression of the cell proliferation following 72 h incubation in 96-well plates with 50% inhibitory concentrations (IC50) of 37.5 ± 1.4 (A2058) and 22.3 ± 1.8 (A375) μmol/L, respectively. d-δ-tocotrienol-mediated cell cycle arrest at the G1 phase was accompanied by decreased expression of cyclin-dependent kinase 4. Concomitantly, procaspase-3 cleavage and morphological changes detected by fluorescence microscopy following acridine orange and ethidium bromide dual staining showed d-δ-tocotrienol-induced apoptosis in melanoma cells. Consequent to mevalonate deprivation and the putatively reduced prenylation and biological half-life of Ras protein, d-δ-tocotrienol induced concentration- and time dependent decrease in the expression of Ras. The impact of d-8-tocotrienol on A2058 cell proliferation was potentiated by lovastatin (IC50 = 3.1± 0.5 μmol/L), a competitive inhibitor of HMG CoA reductase. d-δ-tocotrienol may have potential application in melanoma chemoprevention and/or therapy. Advisors/Committee Members: Mo, Huanbiao (Committee Chair), DiMarco, Nancy (committee member), Hynds, Diana (committee member), Grossie, Bruce (committee member), Vijayagopal, Parakat (committee member).

Subjects/Keywords: Health and environmental sciences; Biological sciences; Isoprenoids; Melanoma; d-delta-tocotrienol; Molecular biology; Nutrition

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APA (6th Edition):

Fernandes, N. V. (2010). Impact of delta-tocotrienol on human melanoma cell proliferation. (Doctoral Dissertation). Texas Woman's University. Retrieved from http://hdl.handle.net/11274/10679

Chicago Manual of Style (16th Edition):

Fernandes, Nicolle Valerie. “Impact of delta-tocotrienol on human melanoma cell proliferation.” 2010. Doctoral Dissertation, Texas Woman's University. Accessed October 25, 2020. http://hdl.handle.net/11274/10679.

MLA Handbook (7th Edition):

Fernandes, Nicolle Valerie. “Impact of delta-tocotrienol on human melanoma cell proliferation.” 2010. Web. 25 Oct 2020.

Vancouver:

Fernandes NV. Impact of delta-tocotrienol on human melanoma cell proliferation. [Internet] [Doctoral dissertation]. Texas Woman's University; 2010. [cited 2020 Oct 25]. Available from: http://hdl.handle.net/11274/10679.

Council of Science Editors:

Fernandes NV. Impact of delta-tocotrienol on human melanoma cell proliferation. [Doctoral Dissertation]. Texas Woman's University; 2010. Available from: http://hdl.handle.net/11274/10679

3. Hussein, Deema. d-δ-tocotrienol-mediated suppression of the proliferation of human PANC-1, MIA PaCa-2, and BxPC-3 pancreatic tumor cells.

Degree: PhD, Nutrition, 2008, Texas Woman's University

The rate-limiting enzyme of the mevalonate pathway, 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, provides essential intermediates for the prenylation or dolichylation of numerous growth-related proteins including nuclear lamins Ras and growth factor receptors. Competitive inhibitors of HMG CoA reductase, the statins, and down-regulators of HMG CoA reductase, the monoterpene geraniol and the sesquitepene farnesol, have been shown to suppress pancreatic tumor growth both in vitro and in vivo by inducing cell cycle arrest and initiating apoptosis. d-δ-Tocotrienol, a vitamin E isomer with a farnesol moiety, has been shown to be growth-suppressive in a number of in vitro and in vivo tumor models. These considerations led to an in vitro evaluation of the tumor-suppressive impact of d-δ-tocotrienol in human MIA PaCa-2 and PANC-1 pancreas carcinoma cells and BxPC-3 pancreas ductal adenocarcinoma cells. d-δ-Tocotrienol induced concentration-dependent suppression of the proliferation of all three cell lines with 50% inhibitory concentrations of 28 ± 6, 35 ± 8, and 35 ± 7 µmol/L for MIA PaCa-2, PANC-1, and BxPC-3, respectively. Cell cycle analyses revealed d-δ-tocotrienol induced Gl arrest in MIA PaCa-2, PANC-1 and BxPC-3 cells. d-δ-Tocotrienol-mediated morphological changes resemble those occurring in apoptotic cells. d-δ-Tocotrienol also induced apoptosis in all three types of pancreatic tumor cells by flow cytometric analysis and fluorescence microscopy. A blend of lovastatin (2 µmol/L) and d-δ-tocotrienol (5 and 10 µmol/L) synergistically suppressed the proliferation of MIA PaCa-2 cells. Supplemental mevalonate attenuated the growth inhibition induced by d-δ-tocotrienol in all three types of pancreatic tumor cells tested. The results of these studies suggested that d-δ-tocotrienol as a down-regulator of the mevalonate pathway may have potential as an adjuvant therapy in pancreatic cancer. Advisors/Committee Members: Mo, Huanbiao (Committee Chair), Grossie, Bruce (committee member), Imrhan, Victorine (committee member), Hsueh, Andie (committee member), Harris, Diane (committee member).

Subjects/Keywords: Health and environmental sciences; Biological sciences; BxPC-3; K-Ras; MIA PaCa-2; PANC-1; Pancreatic cancer; d-delta-tocotrienol

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Hussein, D. (2008). d-δ-tocotrienol-mediated suppression of the proliferation of human PANC-1, MIA PaCa-2, and BxPC-3 pancreatic tumor cells. (Doctoral Dissertation). Texas Woman's University. Retrieved from http://hdl.handle.net/11274/10845

Chicago Manual of Style (16th Edition):

Hussein, Deema. “d-δ-tocotrienol-mediated suppression of the proliferation of human PANC-1, MIA PaCa-2, and BxPC-3 pancreatic tumor cells.” 2008. Doctoral Dissertation, Texas Woman's University. Accessed October 25, 2020. http://hdl.handle.net/11274/10845.

MLA Handbook (7th Edition):

Hussein, Deema. “d-δ-tocotrienol-mediated suppression of the proliferation of human PANC-1, MIA PaCa-2, and BxPC-3 pancreatic tumor cells.” 2008. Web. 25 Oct 2020.

Vancouver:

Hussein D. d-δ-tocotrienol-mediated suppression of the proliferation of human PANC-1, MIA PaCa-2, and BxPC-3 pancreatic tumor cells. [Internet] [Doctoral dissertation]. Texas Woman's University; 2008. [cited 2020 Oct 25]. Available from: http://hdl.handle.net/11274/10845.

Council of Science Editors:

Hussein D. d-δ-tocotrienol-mediated suppression of the proliferation of human PANC-1, MIA PaCa-2, and BxPC-3 pancreatic tumor cells. [Doctoral Dissertation]. Texas Woman's University; 2008. Available from: http://hdl.handle.net/11274/10845

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