subject:(corticostriatal)

University of Texas – Austin

1. Yi, Han-Gyol. The role of corticostriatal loops in auditory category learning.

Degree: PhD, Communication Sciences and Disorders, 2017, University of Texas – Austin

► Sounds can signal danger (e.g., roar of a lion), pleasure, (e.g., music), or carry linguistic relevance (e.g. speech). For sounds to guide behavior, the complex… (more)

▼ Sounds can signal danger (e.g., roar of a lion), pleasure, (e.g., music), or carry linguistic relevance (e.g. speech). For sounds to guide behavior, the complex soundscape must first be appropriately categorized (Bizley & Cohen, 2013; Nelken, Bizley, Shamma, & Wang, 2014). Currently, our understanding of the neural correlates of auditory categorization and learning is largely constrained to the cerebral cortex (Leech, Holt, Devlin, & Dick, 2009; Lim, Fiez, & Holt, 2014; F. Ohl, Scheich, & Freeman, 2001; F. W. Ohl & Scheich, 2005). Here, I focus on the striatum and its extensive connectivity between the cerebral cortex, referred to as corticostriatal loops (Parent & Hazrati, 1995). In vision, these loops have been purported to be involved in sensory, executive, motivational, and motor processing during acquisition of novel categories (Seger & Miller, 2010). An influential theory in visual category learning posits that the executive loop is critical in developing, testing, and using reflective rules to categorize percepts, whereas the motor loop is critical in reflexively learning categories (Ashby & Maddox, 2005, 2011). In this dissertation, I use a combination of structural and functional neuroimaging methods and behavioral training approach to examine the role of corticostriatal loops in auditory category learning. Structurally, I show that the connectivity between the auditory cortex and the caudate nucleus (sensory loop) relates to individual variability in speech category learning. Functionally, I show that successful categorization of speech sounds is associated with greater recruitment of the motor loop during stimulus, and a combination of executive, motivational, and motor loops during feedback processing. Finally, I present evidence that reflective learning of the auditory categories involves recruitment of the prefrontal cortex, whereas reflexive learning primarily involves the motor loop (Ashby & Maddox, 2005, 2011). Altogether, these results suggest that (1) multiple corticostriatal loops are engaged during auditory category learning; (2) successful categorization of a stimulus is contingent on recruitment of the prefrontal or motor cortex; and (3) feedback is integrated throughout training via executive and motivational loops. Advisors/Committee Members: Chandrasekaran, Bharath (advisor), Booth, James R (committee member), Henry, Maya L (committee member), Smiljanic, Rajka (committee member).

Subjects/Keywords: Category learning; Auditory; Corticostriatal loops

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Yi, H. (2017). The role of corticostriatal loops in auditory category learning. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/62983

Chicago Manual of Style (16^th Edition):

Yi, Han-Gyol. “The role of corticostriatal loops in auditory category learning.” 2017. Doctoral Dissertation, University of Texas – Austin. Accessed April 16, 2021. http://hdl.handle.net/2152/62983.

MLA Handbook (7^th Edition):

Yi, Han-Gyol. “The role of corticostriatal loops in auditory category learning.” 2017. Web. 16 Apr 2021.

Vancouver:

Yi H. The role of corticostriatal loops in auditory category learning. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2017. [cited 2021 Apr 16]. Available from: http://hdl.handle.net/2152/62983.

Council of Science Editors:

Yi H. The role of corticostriatal loops in auditory category learning. [Doctoral Dissertation]. University of Texas – Austin; 2017. Available from: http://hdl.handle.net/2152/62983

Universidade do Rio Grande do Norte

2. Brys, Ivani. Modelo animal da Doença de Parkinson baseado na expressão de alfa - sinucleína: caracterização comportamental, eletrofisiológica e avaliação dos efei tos da estimulação da medula espinhal .

Degree: 2014, Universidade do Rio Grande do Norte

URL: http://repositorio.ufrn.br/handle/123456789/19589

► Parkinson disease (PD) is associated with motor symptoms and dopaminergic cell loss in the nigrostriatal pathway. Alpha-synuclein is the major component of the Lewy bodies,… (more)

▼ Parkinson disease (PD) is associated with motor symptoms and dopaminergic cell loss in the nigrostriatal pathway. Alpha-synuclein is the major component of the Lewy bodies, the biological hallmarks of disease, and has been associated with familial cases of PD. Recently, the spinal cord stimulation (SCS) showed to be effective to alleviate the Parkinson symptoms in animal models and human patients. In this project, we characterized the motor and electrophysiological effects of alpha-synuclein overexpression in the substantia nigra of rats. We further investigated the effects of spinal electrical stimulation, AMPT and L-dopa administration in this model. Method: Sprague-Dawley rats were injected with empty viral vector or the vector carrying the gene for alpha-synuclein in the substantia nigra, and were tested weekly for 10 weeks in the open field and cylinder tests. A separated group of animals implanted with bilateral electrode arrays in the motor cortex and the striatum were recorded in the open field, during the SCS sessions and the pharmacological experiments. Results: Alpha-synuclein expression resulted in motor asymmetry, observed as the reduction in use of contralateral forepaw in the cylinder test. Animals showed an increase of local field potential activity in beta band three and four weeks after the virus injection, that was not evident after the 5th week. AMPT resulted in a sever parkinsonian state, with reduction in the locomotor activity and significant peak of oscillatory activity in cortex and striatum. SCS was effective to alleviate the motor asymmetry at long term, but did not reduce the corticostriatal low frequency oscillations observed 24 hs after the AMPT administration. These oscillations were attenuated by L-dopa that, even as SCS, was not effective to restore the locomotor activity during the severe dopaminergic depletion period. Discussion: The alpha-synuclein model reproduces the motor impairment and the progressive neurodegenerative process of PD. We demonstrated, by the first time, that this model also presents the increase in low frequency oscillatory activity in the corticostriatal circuit, compatible with parkinsonian condition; and that SCS has a therapeutic effect on motor symptom of this model. Advisors/Committee Members: Pereira Júnior, Antonio (advisor), 25715330297 (advisor), http://lattes.cnpq.br/1402289786010170 (advisor), Fuentes, Rômulo (advisor), 01798000431 (advisor), http://lattes.cnpq.br/5644114424217760 (advisor).

Subjects/Keywords: Doença de Parkinson; Alfa-sinucleína; circuito corticostriatal

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Brys, I. (2014). Modelo animal da Doença de Parkinson baseado na expressão de alfa - sinucleína: caracterização comportamental, eletrofisiológica e avaliação dos efei tos da estimulação da medula espinhal . (Thesis). Universidade do Rio Grande do Norte. Retrieved from http://repositorio.ufrn.br/handle/123456789/19589

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Brys, Ivani. “Modelo animal da Doença de Parkinson baseado na expressão de alfa - sinucleína: caracterização comportamental, eletrofisiológica e avaliação dos efei tos da estimulação da medula espinhal .” 2014. Thesis, Universidade do Rio Grande do Norte. Accessed April 16, 2021. http://repositorio.ufrn.br/handle/123456789/19589.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Brys, Ivani. “Modelo animal da Doença de Parkinson baseado na expressão de alfa - sinucleína: caracterização comportamental, eletrofisiológica e avaliação dos efei tos da estimulação da medula espinhal .” 2014. Web. 16 Apr 2021.

Vancouver:

Brys I. Modelo animal da Doença de Parkinson baseado na expressão de alfa - sinucleína: caracterização comportamental, eletrofisiológica e avaliação dos efei tos da estimulação da medula espinhal . [Internet] [Thesis]. Universidade do Rio Grande do Norte; 2014. [cited 2021 Apr 16]. Available from: http://repositorio.ufrn.br/handle/123456789/19589.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Brys I. Modelo animal da Doença de Parkinson baseado na expressão de alfa - sinucleína: caracterização comportamental, eletrofisiológica e avaliação dos efei tos da estimulação da medula espinhal . [Thesis]. Universidade do Rio Grande do Norte; 2014. Available from: http://repositorio.ufrn.br/handle/123456789/19589

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Manchester

3. Logie, Christopher. Presynaptic control of corticostriatal inputs: role of GABA.

Degree: 2014, University of Manchester

URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:231232

► The basal ganglia (BG) are a group of nuclei in the basal forebrain critical in movement, goal directed behaviour and action selection. Cortical projections to… (more)

▼ The basal ganglia (BG) are a group of nuclei in the basal forebrain critical in movement, goal directed behaviour and action selection. Cortical projections to the largest BG nucleus, the striatum, are highly important in theories of BG function. Therefore, we have investigated the role of striatal neurons in modulating the activity of corticostriatal synapses. In an in-vitro preparation of rodent brain slices, we conducted whole-cell patch clamp recordings of single and pairs of striatal neurons and recorded responses of medium spiny neurons (MSNs) to stimulation of corticostriatal fibres. In the presence of opioid, GABAA, NK1 and cholinergic receptor antagonists, antidromic stimulation of a population of MSNs (5 stims, 50 Hz) caused suppression of subsequently evoked EPSPs in MSNs. This suppression was dependent upon the interval between antidromic MSN stimulation and the stimulation of evoked EPSPs; suppression was larger at 500 ms intervals than at 1 or 2 s intervals. These effects were completely blocked by the GABAB antagonist CGP 52432. Bursts of evoked action potentials (5 APs, 50 Hz) in a single MSN were insufficient to cause these effects in a nearby MSN. Similar spikes in single fast spiking interneurons and low threshold spiking interneurons (LTSIs) were also insufficient. Conversely, single neurogliaform interneurons (NGFIs) could suppress evoked EPSPs in nearby MSNs in a GABAB-dependent manner. This suppression was more likely in NGFI-MSN pairs that exhibited direct GABAergic interactions. We also tested long depolarisations in LTSIs, a protocol that preferentially releases NO, which was shown to suppress evoked EPSPs through a non-GABAergic mechanism. Finally, we tested the application of exogenous NPY to slices, which also inhibited corticostriatal transmission. These results provide the first demonstration of how GABAB receptors at corticostriatal synapses are activated by endogenous GABA released by striatal neurons. They also reveal novel mechanisms through which striatal factors influence these synapses. Advisors/Committee Members: TURNER, JONATHAN JP, Turner, Jonathan, Turner, Jonathan.

Subjects/Keywords: striatum; electrophysiology; GABA; corticostriatal; action selection

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Logie, C. (2014). Presynaptic control of corticostriatal inputs: role of GABA. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:231232

Chicago Manual of Style (16^th Edition):

Logie, Christopher. “Presynaptic control of corticostriatal inputs: role of GABA.” 2014. Doctoral Dissertation, University of Manchester. Accessed April 16, 2021. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:231232.

MLA Handbook (7^th Edition):

Logie, Christopher. “Presynaptic control of corticostriatal inputs: role of GABA.” 2014. Web. 16 Apr 2021.

Vancouver:

Logie C. Presynaptic control of corticostriatal inputs: role of GABA. [Internet] [Doctoral dissertation]. University of Manchester; 2014. [cited 2021 Apr 16]. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:231232.

Council of Science Editors:

Logie C. Presynaptic control of corticostriatal inputs: role of GABA. [Doctoral Dissertation]. University of Manchester; 2014. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:231232

University of Manchester

4. Logie, Christopher. Presynaptic control of corticostriatal inputs : role of GABA.

Degree: PhD, 2014, University of Manchester

URL: https://www.research.manchester.ac.uk/portal/en/theses/presynaptic-control-of-corticostriatal-inputs-role-of-gaba(380c8d5b-7dc7-4618-a464-8f7104c4db0c).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.626924

► The basal ganglia (BG) are a group of nuclei in the basal forebrain critical in movement, goal directed behaviour and action selection. Cortical projections to… (more)

▼ The basal ganglia (BG) are a group of nuclei in the basal forebrain critical in movement, goal directed behaviour and action selection. Cortical projections to the largest BG nucleus, the striatum, are highly important in theories of BG function. Therefore, we have investigated the role of striatal neurons in modulating the activity of corticostriatal synapses. In an in-vitro preparation of rodent brain slices, we conducted whole-cell patch clamp recordings of single and pairs of striatal neurons and recorded responses of medium spiny neurons (MSNs) to stimulation of corticostriatal fibres. In the presence of opioid, GABAA, NK1 and cholinergic receptor antagonists, antidromic stimulation of a population of MSNs (5 stims, 50 Hz) caused suppression of subsequently evoked EPSPs in MSNs. This suppression was dependent upon the interval between antidromic MSN stimulation and the stimulation of evoked EPSPs; suppression was larger at 500 ms intervals than at 1 or 2 s intervals. These effects were completely blocked by the GABAB antagonist CGP 52432. Bursts of evoked action potentials (5 APs, 50 Hz) in a single MSN were insufficient to cause these effects in a nearby MSN. Similar spikes in single fast spiking interneurons and low threshold spiking interneurons (LTSIs) were also insufficient. Conversely, single neurogliaform interneurons (NGFIs) could suppress evoked EPSPs in nearby MSNs in a GABAB-dependent manner. This suppression was more likely in NGFI-MSN pairs that exhibited direct GABAergic interactions. We also tested long depolarisations in LTSIs, a protocol that preferentially releases NO, which was shown to suppress evoked EPSPs through a non-GABAergic mechanism. Finally, we tested the application of exogenous NPY to slices, which also inhibited corticostriatal transmission. These results provide the first demonstration of how GABAB receptors at corticostriatal synapses are activated by endogenous GABA released by striatal neurons. They also reveal novel mechanisms through which striatal factors influence these synapses.

Subjects/Keywords: 612.8; striatum; electrophysiology; GABA; corticostriatal; action selection

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Logie, C. (2014). Presynaptic control of corticostriatal inputs : role of GABA. (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/presynaptic-control-of-corticostriatal-inputs-role-of-gaba(380c8d5b-7dc7-4618-a464-8f7104c4db0c).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.626924

Chicago Manual of Style (16^th Edition):

Logie, Christopher. “Presynaptic control of corticostriatal inputs : role of GABA.” 2014. Doctoral Dissertation, University of Manchester. Accessed April 16, 2021. https://www.research.manchester.ac.uk/portal/en/theses/presynaptic-control-of-corticostriatal-inputs-role-of-gaba(380c8d5b-7dc7-4618-a464-8f7104c4db0c).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.626924.

MLA Handbook (7^th Edition):

Logie, Christopher. “Presynaptic control of corticostriatal inputs : role of GABA.” 2014. Web. 16 Apr 2021.

Vancouver:

Logie C. Presynaptic control of corticostriatal inputs : role of GABA. [Internet] [Doctoral dissertation]. University of Manchester; 2014. [cited 2021 Apr 16]. Available from: https://www.research.manchester.ac.uk/portal/en/theses/presynaptic-control-of-corticostriatal-inputs-role-of-gaba(380c8d5b-7dc7-4618-a464-8f7104c4db0c).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.626924.

Council of Science Editors:

Logie C. Presynaptic control of corticostriatal inputs : role of GABA. [Doctoral Dissertation]. University of Manchester; 2014. Available from: https://www.research.manchester.ac.uk/portal/en/theses/presynaptic-control-of-corticostriatal-inputs-role-of-gaba(380c8d5b-7dc7-4618-a464-8f7104c4db0c).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.626924

Vanderbilt University

5. Eckstrand, Kristen Laurel. Corticostriatal dopamine networks mediate impulsivity in obesity and insulin resistance.

Degree: PhD, Neuroscience, 2013, Vanderbilt University

URL: http://hdl.handle.net/1803/14191

► Obesity and obesity-associated disease together are a leading cause of death worldwide. Recent research demonstrates striking similarities between obesity and addiction in their dysregulation of… (more)

Subjects/Keywords: corticostriatal; addiction; impulsivity; visceral adiposity; insulin resistance; obesity; dopamine

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Eckstrand, K. L. (2013). Corticostriatal dopamine networks mediate impulsivity in obesity and insulin resistance. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/14191

Chicago Manual of Style (16^th Edition):

Eckstrand, Kristen Laurel. “Corticostriatal dopamine networks mediate impulsivity in obesity and insulin resistance.” 2013. Doctoral Dissertation, Vanderbilt University. Accessed April 16, 2021. http://hdl.handle.net/1803/14191.

MLA Handbook (7^th Edition):

Eckstrand, Kristen Laurel. “Corticostriatal dopamine networks mediate impulsivity in obesity and insulin resistance.” 2013. Web. 16 Apr 2021.

Vancouver:

Eckstrand KL. Corticostriatal dopamine networks mediate impulsivity in obesity and insulin resistance. [Internet] [Doctoral dissertation]. Vanderbilt University; 2013. [cited 2021 Apr 16]. Available from: http://hdl.handle.net/1803/14191.

Council of Science Editors:

Eckstrand KL. Corticostriatal dopamine networks mediate impulsivity in obesity and insulin resistance. [Doctoral Dissertation]. Vanderbilt University; 2013. Available from: http://hdl.handle.net/1803/14191

University of California – San Francisco

6. Parker, Philip Ross Lutton. Acute and Chronic Dopaminergic Modulation of Striatal Circuitry and Function in Health and Disease.

Degree: Neuroscience, 2015, University of California – San Francisco

URL: http://www.escholarship.org/uc/item/9jr78043

► The basal ganglia are an evolutionarily conserved set of nuclei that are crucial for context-dependent learning and selection of appropriate behavioral outputs. The striatum is… (more)

▼ The basal ganglia are an evolutionarily conserved set of nuclei that are crucial for context-dependent learning and selection of appropriate behavioral outputs. The striatum is considered the input nucleus of the basal ganglia because it not only receives the bulk of excitatory synaptic drive from sources outside the basal ganglia, but also contains two populations of medium spiny neurons that give rise to the direct and indirect basal ganglia pathways. The activity of direct and indirect pathway medium spiny neurons (dMSNs and iMSNs) is sufficient to promote or suppress behavioral output, respectively. Changes in synaptic strength at excitatory inputs to MSNs are thought to underlie context-dependent learning, whereas the acute modulation of MSN intrinsic excitability affects motivation or vigor of an ongoing behavior. Previous research has revealed that the neuromodulator dopamine appears to be in a unique position to exert both acute and chronic modulatory effects over MSNs and their excitatory inputs. The differential expression of Gs-coupled D1 and Gi-coupled D2 receptors by dMSNs and iMSNs, respectively, results in opposing changes in direct and indirect pathway function with changes in striatal dopamine levels. However, previous technical limitations have restricted the study of dopamine's acute actions in the striatum and the long-term effects of dopamine on MSN subtypes and excitatory inputs of distinct origins. Here we use recently developed optogenetic and chemogenetic techniques combined with behavior and ex vivo brain slice electrophysiology to study the mechanisms of acute and chronic dopamine signaling in MSNs and their excitatory inputs. In Chapter One, we review the evidence for the dual-pathway model of basal ganglia function and its modulation by dopamine in the context of controlling behavioral output. In Chapter Two, we perform an electrophysiological comparison of common optogenetic proteins to determine the optimal tool for our experiments. We then use optogenetic control of dopamine release to show specific modulation of dMSN intrinsic excitability and D1-mediated invigoration of behavior in Chapter Three. In Chapter Four, we provide evidence that the chronic loss of dopamine in Parkinson's disease results in a reorganization of the thalamostriatal system that has negative outcomes on motor control. Finally, we discuss the overarching implications of these findings in the context of basal ganglia function in health and disease in Chapter Five. These findings not only represent a long overdue reevaluation of the assumptions surrounding the role of dopamine in striatal function, but also provide new testable hypotheses addressing the cellular and synaptic bases of an evolutionarily conserved system for the dynamic regulation of ethologically relevant behaviors.

Subjects/Keywords: Neurosciences; basal ganglia; corticostriatal; electrophysiology; Parkinson's disease; synaptic plasticity; thalamostriatal

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Parker, P. R. L. (2015). Acute and Chronic Dopaminergic Modulation of Striatal Circuitry and Function in Health and Disease. (Thesis). University of California – San Francisco. Retrieved from http://www.escholarship.org/uc/item/9jr78043

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Parker, Philip Ross Lutton. “Acute and Chronic Dopaminergic Modulation of Striatal Circuitry and Function in Health and Disease.” 2015. Thesis, University of California – San Francisco. Accessed April 16, 2021. http://www.escholarship.org/uc/item/9jr78043.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Parker, Philip Ross Lutton. “Acute and Chronic Dopaminergic Modulation of Striatal Circuitry and Function in Health and Disease.” 2015. Web. 16 Apr 2021.

Vancouver:

Parker PRL. Acute and Chronic Dopaminergic Modulation of Striatal Circuitry and Function in Health and Disease. [Internet] [Thesis]. University of California – San Francisco; 2015. [cited 2021 Apr 16]. Available from: http://www.escholarship.org/uc/item/9jr78043.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Parker PRL. Acute and Chronic Dopaminergic Modulation of Striatal Circuitry and Function in Health and Disease. [Thesis]. University of California – San Francisco; 2015. Available from: http://www.escholarship.org/uc/item/9jr78043

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

7. Brys, Ivani. Modelo animal da Doença de Parkinson baseado na expressão de alfa - sinucleína: caracterização comportamental, eletrofisiológica e avaliação dos efei tos da estimulação da medula espinhal.

Degree: 2014, Federal University of Rio Grande do Norte

URL: https://repositorio.ufrn.br/jspui/handle/123456789/19589

►

Conselho Nacional de Desenvolvimento Científico e Tecnológico - CNPq

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES

A Doença de Parkinson (DP) está… (more)

▼

Conselho Nacional de Desenvolvimento Científico e Tecnológico - CNPq

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES

A Doença de Parkinson (DP) está associada a sintomas motores e à perda de neurônios dopaminérgicos na via nigroestriatal. A proteína alfa-sinucleína é o principal componente dos corpos de Lewy, marcadores biológicos da doença, e tem sido associada a casos de Parkinson hereditário. Recentemente, a estimulação da medula espinhal (EME) tem se mostrado um método de neuromodulação efetivo em aliviar os sintomas parkinsonianos em modelos animais e pacientes humanos da DP. Nesse projeto, caracterizamos os efeitos motores e eletrofisiológicos da expressão de alfa-sinucleína na substância nigra de ratos. Além disso, investigamos os efeitos da administração de AMPT, L-dopa e da aplicação de EME nesse modelo. Método: Ratos Sprague-Dawley receberam injeção unilateral de vetor viral vazio ou para expressar alfa-sinucleína na substância nigra e foram avaliados semanalmente na tarefa do campo aberto e do cilindro. Um grupo separado de animais implantados com matrizes bilaterais de eletrodos no córtex motor e no estriado foram registrados semanalmente no campo aberto, durante as sessões de EME e nos experimentos farmacológicos. Resultados: A expressão de alfa-sinucleína resultou em assimetria motora, observada na redução do uso da pata contralateral na tarefa do cilindro. Os animais apresentaram aumento da atividade de potencial de campo local estriatal em beta após três e quatro semanas de expressão de alfa-sinucleína, que desapareceu a partir da quinta semana. A administração de AMPT resultou em um quadro parkinsoniano severo, com redução da atividade locomotora e significativo aparecimento do pico de atividade oscilatória em beta no estriado e no cortex desse modelo. A EME mostrou-se efetiva em aliviar a assimetria motora em longo prazo, mas não reduziu as oscilações corticostriatais de baixa frequência observadas 24 hs após a administração de AMPT. Essas oscilações foram atenuadas pela administração de L-dopa que, de forma semelhante à EME, não foi efetiva em restaurar a atividade locomotora dos animais durante esse quadro de depleção severa de dopamina. Discussão: O modelo alfa-sinucleína da DP reproduz o prejuízo motor e a condição progressiva do processo neurodegenerativo. Nós demonstramos, pela primeira vez, que esse modelo apresenta também aumento da atividade corticostriatal oscilatória na banda beta compatível com as características da doença e que a EME tem efeito terapêutico sobre o sintoma motor desse modelo.

Parkinson disease (PD) is associated with motor symptoms and dopaminergic cell loss in the nigrostriatal pathway. Alpha-synuclein is the major component of the Lewy bodies, the biological hallmarks of disease, and has been associated with familial cases of PD. Recently, the spinal cord stimulation (SCS) showed to be effective to alleviate the Parkinson symptoms in animal models and human patients. In this project, we characterized the motor and electrophysiological…

Advisors/Committee Members: http://lattes.cnpq.br/1402289786010170, Godeiro Júnior, Clecio de Oliveira, http://lattes.cnpq.br/6861574542099266, Araújo, Mariana Ferreira Pereira de, http://lattes.cnpq.br/8680061079519776, Moioli, Renan Cipriano, http://lattes.cnpq.br/3898958813303048, Fuentes, Rômulo, Pereira Júnior, Antonio.

Subjects/Keywords: CNPQ::CIENCIAS BIOLOGICAS; Doença de Parkinson; Alfa-sinucleína; circuito corticostriatal

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Brys, I. (2014). Modelo animal da Doença de Parkinson baseado na expressão de alfa - sinucleína: caracterização comportamental, eletrofisiológica e avaliação dos efei tos da estimulação da medula espinhal. (Doctoral Dissertation). Federal University of Rio Grande do Norte. Retrieved from https://repositorio.ufrn.br/jspui/handle/123456789/19589

Chicago Manual of Style (16^th Edition):

Brys, Ivani. “Modelo animal da Doença de Parkinson baseado na expressão de alfa - sinucleína: caracterização comportamental, eletrofisiológica e avaliação dos efei tos da estimulação da medula espinhal.” 2014. Doctoral Dissertation, Federal University of Rio Grande do Norte. Accessed April 16, 2021. https://repositorio.ufrn.br/jspui/handle/123456789/19589.

MLA Handbook (7^th Edition):

Brys, Ivani. “Modelo animal da Doença de Parkinson baseado na expressão de alfa - sinucleína: caracterização comportamental, eletrofisiológica e avaliação dos efei tos da estimulação da medula espinhal.” 2014. Web. 16 Apr 2021.

Vancouver:

Brys I. Modelo animal da Doença de Parkinson baseado na expressão de alfa - sinucleína: caracterização comportamental, eletrofisiológica e avaliação dos efei tos da estimulação da medula espinhal. [Internet] [Doctoral dissertation]. Federal University of Rio Grande do Norte; 2014. [cited 2021 Apr 16]. Available from: https://repositorio.ufrn.br/jspui/handle/123456789/19589.

Council of Science Editors:

Brys I. Modelo animal da Doença de Parkinson baseado na expressão de alfa - sinucleína: caracterização comportamental, eletrofisiológica e avaliação dos efei tos da estimulação da medula espinhal. [Doctoral Dissertation]. Federal University of Rio Grande do Norte; 2014. Available from: https://repositorio.ufrn.br/jspui/handle/123456789/19589

UCLA

8. Groman, Stephanie Mary. The Dopamine D2-like Receptor: At the Nexus Between Self-Control and Addiction.

Degree: Psychology, 2013, UCLA

URL: http://www.escholarship.org/uc/item/82w18059

► Addictions are multi-dimensional disorders, consisting of several behavioral, affective and cognitive dysfunctions that contribute to the compulsive and persistent drug-seeking and taking that is common… (more)

▼ Addictions are multi-dimensional disorders, consisting of several behavioral, affective and cognitive dysfunctions that contribute to the compulsive and persistent drug-seeking and taking that is common to them. Cognitive control, which includes the ability to flexibly and adaptively inhibit undesirable actions (including drug-seeking), is a particularly relevant dimension of addiction, with deficits in cognitive control occurring in response to experience with drugs of abuse, as well as predicting the susceptibility for future drug-taking behaviors. The bi-directional relationship between cognitive control and substance dependence raises the possibility that these processes are governed by a common neural circuitry and emerging evidence indicates that the dopamine D2-like receptor system may be the point of convergence of these phenomena. To determine the influence of the dopamine D2-like receptor system on cognitive control processes within the context of addictions, neuroimaging, behavioral and biochemical techniques were used to interrogate how naturally occurring and drug-induced variation in D2-like receptor system may alter cognitive-control processes. Individual differences in D2-like receptor availability, assessed with positron emission tomography, was positively related to adaptive responding following the reversal of stimulus-reward contingencies and to the sensitivity of individuals to positive feedback. Exposure to an escalating dose regimen of methamphetamine reduced D2-like receptor availability, and the degree of D2-like receptor dysfunction was correlated with the change in positive-feedback sensitivity. Cross-dimensional measurement of the D2-like receptor systems using in vivo and in vitro techniques provided evidence that deviations in D2-like receptor availability reflected actions on functionally and behaviorally relevant pools of D2-like receptors. Finally, evidence supporting the utility of spontaneous eye blink rate as a non-invasive measure of D2-like receptors was obtained from studies of rodents. These studies provide converging support, at multiple levels of analyses, that the D2-like receptor is a common molecular determinant of addiction and cognitive control, providing a mechanistic explanation for the bi-directional relationship between these processes.

Subjects/Keywords: Neurosciences; Psychobiology; Addiction; Cognitive control; Corticostriatal circuit; D2-like receptor; Dopamine; Feedback sensitivity

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Groman, S. M. (2013). The Dopamine D2-like Receptor: At the Nexus Between Self-Control and Addiction. (Thesis). UCLA. Retrieved from http://www.escholarship.org/uc/item/82w18059

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Groman, Stephanie Mary. “The Dopamine D2-like Receptor: At the Nexus Between Self-Control and Addiction.” 2013. Thesis, UCLA. Accessed April 16, 2021. http://www.escholarship.org/uc/item/82w18059.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Groman, Stephanie Mary. “The Dopamine D2-like Receptor: At the Nexus Between Self-Control and Addiction.” 2013. Web. 16 Apr 2021.

Vancouver:

Groman SM. The Dopamine D2-like Receptor: At the Nexus Between Self-Control and Addiction. [Internet] [Thesis]. UCLA; 2013. [cited 2021 Apr 16]. Available from: http://www.escholarship.org/uc/item/82w18059.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Groman SM. The Dopamine D2-like Receptor: At the Nexus Between Self-Control and Addiction. [Thesis]. UCLA; 2013. Available from: http://www.escholarship.org/uc/item/82w18059

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Iowa

9. Lee, Joanna Chen. Are individual differences in language associated with differences in the corticostriatal system? A behavioral and imaging study.

Degree: PhD, Speech and Hearing Science, 2012, University of Iowa

URL: https://ir.uiowa.edu/etd/2927

► The overall aim of the current research was to investigate the corticostriatal system in developmental language impairment (DLI) at the behavioral and neuroanatomical levels.… (more)

▼ The overall aim of the current research was to investigate the corticostriatal system in developmental language impairment (DLI) at the behavioral and neuroanatomical levels. Two groups of young adults, one with DLI (N = 25) and the other without (N = 23), participated in the behavioral study. A sample of procedural learning and reinforcement learning (RL) tasks was selected. Each task represents a unique aspect of procedural memory, and learning processes during these tasks have been linked, at least partially, to the functionality of the corticostriatal system. Findings showed that individuals with DLI demonstrated relatively poor performance on different aspects of procedural learning and on RL. Correlation results provide further evidence for a close relationship between individual differences in implicit learning and individual differences in language. These results implicate an abnormal corticostriatal system in DLI. In the structural imaging study, two subgroups of participants from the first study, one with DLI (n = 10) and the other without (n = 10), were matched on age, gender, and handedness. Conventional magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) were used to investigate the subcortical components of the corticostriatal system in individuals with DLI. Results showed pathological enlargement in the bilateral putamen, the right globus pallidus, and the bilateral nucleus accumbens of individuals with DLI. In addition, the DLI group revealed decreased FA in the globus pallidus and in the thalamus, indicating abnormal white matter integrity in the two subcortical regions. These imaging results underpin the behavioral results, showing corticostriatal abnormalities in DLI at both macrostructural and microstructural levels. In addition to subcortical regions, the four cerebral lobes were also included for an exploratory analysis. Findings showed that individuals with DLI had global diffusion abnormalities in cerebral white matters in the absence of volumetric alterations, and these abnormalities were closely associated with impaired language performance. The results support a role of white matter integrity in language function. In conclusion, individuals with DLI have an abnormal corticostriatal system, which may lead to compromise of a wide variety of cognitive learning, including procedural learning, RL, and certain aspects of language learning. Advisors/Committee Members: Tomblin, J. Bruce (supervisor).

Subjects/Keywords: corticostriatal system; Developmental language impairment; procedural learning; reinforcement learning; Speech and Hearing Science

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lee, J. C. (2012). Are individual differences in language associated with differences in the corticostriatal system? A behavioral and imaging study. (Doctoral Dissertation). University of Iowa. Retrieved from https://ir.uiowa.edu/etd/2927

Chicago Manual of Style (16^th Edition):

Lee, Joanna Chen. “Are individual differences in language associated with differences in the corticostriatal system? A behavioral and imaging study.” 2012. Doctoral Dissertation, University of Iowa. Accessed April 16, 2021. https://ir.uiowa.edu/etd/2927.

MLA Handbook (7^th Edition):

Lee, Joanna Chen. “Are individual differences in language associated with differences in the corticostriatal system? A behavioral and imaging study.” 2012. Web. 16 Apr 2021.

Vancouver:

Lee JC. Are individual differences in language associated with differences in the corticostriatal system? A behavioral and imaging study. [Internet] [Doctoral dissertation]. University of Iowa; 2012. [cited 2021 Apr 16]. Available from: https://ir.uiowa.edu/etd/2927.

Council of Science Editors:

Lee JC. Are individual differences in language associated with differences in the corticostriatal system? A behavioral and imaging study. [Doctoral Dissertation]. University of Iowa; 2012. Available from: https://ir.uiowa.edu/etd/2927

University of Texas – Austin

10. Valenzuela, Krystal Schaar. Behavioral experience effects on forelimb strength recovery and corticostriatal axonal plasticity after experimental middle cerebral artery occlusion.

Degree: PhD, Psychology, 2018, University of Texas – Austin

URL: http://hdl.handle.net/2152/72811

► The overarching goal of this dissertation project is to test how behavioral experiences with the paretic and non-paretic forelimbs influence recovery of paretic forelimb strength… (more)

▼ The overarching goal of this dissertation project is to test how behavioral experiences with the paretic and non-paretic forelimbs influence recovery of paretic forelimb strength and corticostriatal projections after strokes caused by occlusion of the middle cerebral artery. In order to accomplish this goal, we pursued the following specific aims: 1) to establish a model that characterizes paretic forelimb weakness using an automated skilled reaching task after middle cerebral artery occlusion (MCAo) in the rat, 2) to test the effects of skilled rehabilitative strength training on paretic forelimb recovery and corticostriatal axonal plasticity after MCAo, and 3) to test whether training with the non-paretic forelimb interferes with recovery of the paretic forelimb and its effects on axonal plasticity after MCAo. The results from the study assessing the first aim are described in chapter 2. We found that the Isometric Pull Task, an automated skilled reaching task, detects forelimb weakness after experimental MCAo. Furthermore, we found that the intraluminal suture MCAo model consistently produces large infarcts damaging somatosensory cortex and striatum. The results for the second aim are described in chapter 3, where we show that daily rehabilitative training with the paretic forelimb for six weeks on the Isometric Pull Task improves paretic forelimb strength after MCAo. We also found that rehabilitative training reduces contralesional striatal axon projections but does not affect contralesional cortical or ipsilesional striatal axon projections that originate from cortex of the lesioned hemisphere. The results for the third aim are described in chapter 4, where we show that 14 days of non-paretic forelimb training post-MCAo on the Isometric Pull Task does not reduce the efficacy of rehabilitative training. These findings suggest that compensating with the intact body side early after stroke may not always be detrimental to recovery and may depend on infarct locus. We also show that non-paretic limb use after MCAo does not influence corticostriatal axonal plasticity. These findings are consistent with the lack of behavioral effect of non-paretic limb training. We finish in chapter 5 by summarizing the results and discussing the implications and potential future direction of this work. Advisors/Committee Members: Jones, Theresa A. (advisor), Noble, Linda (committee member), Delville, Yvon (committee member), Sulzer, James (committee member).

Subjects/Keywords: Forelimb strength; MCAo; Axons; Plasticity; Corticostriatal; Rehabilitative training; Non-paretic limb training; Stroke; Rat

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Valenzuela, K. S. (2018). Behavioral experience effects on forelimb strength recovery and corticostriatal axonal plasticity after experimental middle cerebral artery occlusion. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/72811

Chicago Manual of Style (16^th Edition):

Valenzuela, Krystal Schaar. “Behavioral experience effects on forelimb strength recovery and corticostriatal axonal plasticity after experimental middle cerebral artery occlusion.” 2018. Doctoral Dissertation, University of Texas – Austin. Accessed April 16, 2021. http://hdl.handle.net/2152/72811.

MLA Handbook (7^th Edition):

Valenzuela, Krystal Schaar. “Behavioral experience effects on forelimb strength recovery and corticostriatal axonal plasticity after experimental middle cerebral artery occlusion.” 2018. Web. 16 Apr 2021.

Vancouver:

Valenzuela KS. Behavioral experience effects on forelimb strength recovery and corticostriatal axonal plasticity after experimental middle cerebral artery occlusion. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2018. [cited 2021 Apr 16]. Available from: http://hdl.handle.net/2152/72811.

Council of Science Editors:

Valenzuela KS. Behavioral experience effects on forelimb strength recovery and corticostriatal axonal plasticity after experimental middle cerebral artery occlusion. [Doctoral Dissertation]. University of Texas – Austin; 2018. Available from: http://hdl.handle.net/2152/72811

University of Lund

11. Sjöbom, Joel. The role of cortico-basal ganglia systems in the construction of movement: Action selection and sequencing.

Degree: 2021, University of Lund

URL: https://lup.lub.lu.se/record/2c49e079-eece-4c6a-940d-ad2422c03279 ; https://portal.research.lu.se/ws/files/89713201/Thesis_Joel_Sj_bom_digital_online_version.pdf

► The cortico-basal ganglia system is instrumental in the construction of movement, through its involvement in aspects such as action selection, initiation/termination and sequencing, though the… (more)

Subjects/Keywords: Neurosciences; Neurophysiology; Electrophysiology; Voluntary movements; In-vivo; Motor Cortex; Corticostriatal; Basal Ganglia

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sjöbom, J. (2021). The role of cortico-basal ganglia systems in the construction of movement: Action selection and sequencing. (Doctoral Dissertation). University of Lund. Retrieved from https://lup.lub.lu.se/record/2c49e079-eece-4c6a-940d-ad2422c03279 ; https://portal.research.lu.se/ws/files/89713201/Thesis_Joel_Sj_bom_digital_online_version.pdf

Chicago Manual of Style (16^th Edition):

Sjöbom, Joel. “The role of cortico-basal ganglia systems in the construction of movement: Action selection and sequencing.” 2021. Doctoral Dissertation, University of Lund. Accessed April 16, 2021. https://lup.lub.lu.se/record/2c49e079-eece-4c6a-940d-ad2422c03279 ; https://portal.research.lu.se/ws/files/89713201/Thesis_Joel_Sj_bom_digital_online_version.pdf.

MLA Handbook (7^th Edition):

Sjöbom, Joel. “The role of cortico-basal ganglia systems in the construction of movement: Action selection and sequencing.” 2021. Web. 16 Apr 2021.

Vancouver:

Sjöbom J. The role of cortico-basal ganglia systems in the construction of movement: Action selection and sequencing. [Internet] [Doctoral dissertation]. University of Lund; 2021. [cited 2021 Apr 16]. Available from: https://lup.lub.lu.se/record/2c49e079-eece-4c6a-940d-ad2422c03279 ; https://portal.research.lu.se/ws/files/89713201/Thesis_Joel_Sj_bom_digital_online_version.pdf.

Council of Science Editors:

Sjöbom J. The role of cortico-basal ganglia systems in the construction of movement: Action selection and sequencing. [Doctoral Dissertation]. University of Lund; 2021. Available from: https://lup.lub.lu.se/record/2c49e079-eece-4c6a-940d-ad2422c03279 ; https://portal.research.lu.se/ws/files/89713201/Thesis_Joel_Sj_bom_digital_online_version.pdf

University of Lund

12. Tamté, Martin. The Role of the Cortico-Basal Ganglia-System in Voluntary Movements.

Degree: 2016, University of Lund

URL: https://lup.lub.lu.se/record/8776791 ; https://portal.research.lu.se/ws/files/3163803/8776834.pdf

► Bodies with multiple limbs and joints have endless possibilities to move around in their surrounding space. How the nervous system controls this amount of degrees… (more)

▼ Bodies with multiple limbs and joints have endless possibilities to move around in their surrounding space. How the nervous system controls this amount of degrees of freedom in motor execution is a question under vigorous debate. In an ambition to explore related aspects of motor control we conducted parallel electrophysiological recordings of motor circuits in the cortex and basal ganglia in the consciously behaving rodent during the execution of various motor behaviors. To be able to further explore the relevance of neuronal activation patterns for different behaviours within these motor structures, we developed two methods - one focusing on increasing the amount of information acquired from the neuronal recordings and the other on improved motion tracking. The first method enabled a flexible electrode construction for targeting of multiple regions of the brain simultaneously. In the motion tracking system an anatomically defined model of the rodent paw was developed. With high resolution recordings a detailed reconstruction of a complex movement permitted differentiation of multiple kinematic parameters that could be related to the electrophysiological recordings. In experiments employing a reach and grasp paradigm, we were able to correlate the neuronal code to a previously suggested subdivision of the compound movement into functional sub-components, in effect validating the method. In further studies we utilized the 6-OHDA rodent model of Parkinson’s disease, where motor control is impaired. Here we found that levodopa induced-dyskinesia was tightly associated with a strong oscillatory phenomenon in the motor cortex, and that stopping the oscillation locally was sufficient for alleviation of motor symptoms. By expanding the neuronal recordings using the developed electrode we showed that different states of the disease could be reliably discerned. When comparing these disease states with a control state, we could thus assess the effect of drugs in their ability to normalize disease-relevant signals. The validity of this procedure was verified by correlation between the behavioral and neuronal measures. These experiments demonstrate that neuronal measures of internal states can be utilized for evaluation of new treatment strategies and have a high potential in aiding drug development for diseases without clear behavioral phenotypes.

Subjects/Keywords: Neurosciences; Neurophysiology; Electrophysiology; Pharmacology; Motor Systems; Voluntary movements; Philosophy; In vivo; Corticostriatal; Parkinson's disease; Dyskinesia; Levodopa; Multiple Electrode Arrays

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tamté, M. (2016). The Role of the Cortico-Basal Ganglia-System in Voluntary Movements. (Doctoral Dissertation). University of Lund. Retrieved from https://lup.lub.lu.se/record/8776791 ; https://portal.research.lu.se/ws/files/3163803/8776834.pdf

Chicago Manual of Style (16^th Edition):

Tamté, Martin. “The Role of the Cortico-Basal Ganglia-System in Voluntary Movements.” 2016. Doctoral Dissertation, University of Lund. Accessed April 16, 2021. https://lup.lub.lu.se/record/8776791 ; https://portal.research.lu.se/ws/files/3163803/8776834.pdf.

MLA Handbook (7^th Edition):

Tamté, Martin. “The Role of the Cortico-Basal Ganglia-System in Voluntary Movements.” 2016. Web. 16 Apr 2021.

Vancouver:

Tamté M. The Role of the Cortico-Basal Ganglia-System in Voluntary Movements. [Internet] [Doctoral dissertation]. University of Lund; 2016. [cited 2021 Apr 16]. Available from: https://lup.lub.lu.se/record/8776791 ; https://portal.research.lu.se/ws/files/3163803/8776834.pdf.

Council of Science Editors:

Tamté M. The Role of the Cortico-Basal Ganglia-System in Voluntary Movements. [Doctoral Dissertation]. University of Lund; 2016. Available from: https://lup.lub.lu.se/record/8776791 ; https://portal.research.lu.se/ws/files/3163803/8776834.pdf

University of New Mexico

13. Marquardt, Kristin L. CORTICO-STRIATAL COORDINATION DISRUPTED IN BEHAVIORALLY INFLEXIBLE MODERATE PRENATAL ALCOHOL EXPOSED MICE.

Degree: Biomedical Sciences Graduate Program, 2017, University of New Mexico

URL: https://digitalrepository.unm.edu/biom_etds/168

► Up to 61% of adolescent school aged children with fetal alcohol spectrum disorder (FASD) have been suspended or expelled. Executive function deficits, like dis-inhibition… (more)

Subjects/Keywords: in vivo electrophysiology; prenatal alcohol; reversal; orbital frontal cortex; corticostriatal; Behavioral Neurobiology; Cognitive Neuroscience; Medicine and Health Sciences

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Marquardt, K. L. (2017). CORTICO-STRIATAL COORDINATION DISRUPTED IN BEHAVIORALLY INFLEXIBLE MODERATE PRENATAL ALCOHOL EXPOSED MICE. (Doctoral Dissertation). University of New Mexico. Retrieved from https://digitalrepository.unm.edu/biom_etds/168

Chicago Manual of Style (16^th Edition):

Marquardt, Kristin L. “CORTICO-STRIATAL COORDINATION DISRUPTED IN BEHAVIORALLY INFLEXIBLE MODERATE PRENATAL ALCOHOL EXPOSED MICE.” 2017. Doctoral Dissertation, University of New Mexico. Accessed April 16, 2021. https://digitalrepository.unm.edu/biom_etds/168.

MLA Handbook (7^th Edition):

Marquardt, Kristin L. “CORTICO-STRIATAL COORDINATION DISRUPTED IN BEHAVIORALLY INFLEXIBLE MODERATE PRENATAL ALCOHOL EXPOSED MICE.” 2017. Web. 16 Apr 2021.

Vancouver:

Marquardt KL. CORTICO-STRIATAL COORDINATION DISRUPTED IN BEHAVIORALLY INFLEXIBLE MODERATE PRENATAL ALCOHOL EXPOSED MICE. [Internet] [Doctoral dissertation]. University of New Mexico; 2017. [cited 2021 Apr 16]. Available from: https://digitalrepository.unm.edu/biom_etds/168.

Council of Science Editors:

Marquardt KL. CORTICO-STRIATAL COORDINATION DISRUPTED IN BEHAVIORALLY INFLEXIBLE MODERATE PRENATAL ALCOHOL EXPOSED MICE. [Doctoral Dissertation]. University of New Mexico; 2017. Available from: https://digitalrepository.unm.edu/biom_etds/168

University of Michigan

14. Simen, Patrick A. Neural mechanisms for control in complex cognition.

Degree: PhD, Psychology, 2004, University of Michigan

URL: http://hdl.handle.net/2027.42/124182

► Neural network models of complex cognitive tasks are difficult to build. Most previous work has focused on the difficulty of using structured symbolic representations in… (more)

▼ Neural network models of complex cognitive tasks are difficult to build. Most previous work has focused on the difficulty of using structured symbolic representations in neural networks. This thesis focuses on the problem of control. During problem solving, some form of control is necessary for sequencing operations, for selecting actions, and for manipulating goal representations. I present a set of control mechanisms inspired and constrained by brain organization that are powerful enough to guarantee basic problem solving ability; in fact, I show that they are computationally universal. These mechanisms exploit a simple method for controlling the temporal characteristics of activation in continuous-time neural networks that makes neural control of complex processes possible in properly organized neural cognitive models. The basic computational primitive is inspired by corticostriatal loops in which the cortical component is composed of columns organized in layers. An input layer and an output layer each form winner-take-all networks. These layers are connected via a corticostriatal loop that produces a controllable amount of internal propagation delay in signal transmission from input layer to output layer. Modules can be composed hierarchically to produce goal-directed control circuits for cognitive models that are formally equivalent to finite automata and share many properties of symbolic production systems. These control circuits are instantiated in a neural cognitive model of the Tower of London problem-solving task. The model implements the assumption that dorsolateral prefrontal cortex is preferentially involved in representing subgoal information during problem solving, and that frontostriatal loop circuits provide a timing function that is critical for proper problem solving performance. Normal subject performance is accurately simulated by the model, and performance under conditions of simulated prefrontal lesions and Parkinson's disease captures speed and accuracy impairments exhibited in patient data from the literature. Advisors/Committee Members: Polk, Thad (advisor).

Subjects/Keywords: Cognition; Complex; Control; Corticostriatal Loops; Mechanisms; Neural Networks; Parkinson's Disease; Prefrontal Cortex

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Simen, P. A. (2004). Neural mechanisms for control in complex cognition. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/124182

Chicago Manual of Style (16^th Edition):

Simen, Patrick A. “Neural mechanisms for control in complex cognition.” 2004. Doctoral Dissertation, University of Michigan. Accessed April 16, 2021. http://hdl.handle.net/2027.42/124182.

MLA Handbook (7^th Edition):

Simen, Patrick A. “Neural mechanisms for control in complex cognition.” 2004. Web. 16 Apr 2021.

Vancouver:

Simen PA. Neural mechanisms for control in complex cognition. [Internet] [Doctoral dissertation]. University of Michigan; 2004. [cited 2021 Apr 16]. Available from: http://hdl.handle.net/2027.42/124182.

Council of Science Editors:

Simen PA. Neural mechanisms for control in complex cognition. [Doctoral Dissertation]. University of Michigan; 2004. Available from: http://hdl.handle.net/2027.42/124182

15. Baker, Phillip M. Contributions of the Prelimbic Cortex and Basal Ganglia Circuitry to Proactive Behavioral Switching.

Degree: 2013, University of Illinois – Chicago

URL: http://hdl.handle.net/10027/9977

► Frontal cortex- basal ganglia circuitry supports behavioral switching when a change in outcome information is used to shift strategies. Less is known about whether specific… (more)

▼ Frontal cortex- basal ganglia circuitry supports behavioral switching when a change in outcome information is used to shift strategies. Less is known about whether specific frontal cortex-basal ganglia circuitry supports proactive switching when cues signal that a change in strategies should occur. The present experiments investigated whether the prelimbic cortex and its connections with two basal ganglia structures, the subthalamic nucleus, and the dorsomedial striatum in male Long-Evans rats supports proactive switching between visual cue-place associations. In a cross-maze, rats learned a conditional discrimination in which a start arm cue (black or white) signaled which one of two maze arms to enter for a food reward. The cue was switched every 3-6 trials. In the first set of experiments, baclofen and muscimol infused into the prelimbic cortex significantly impaired performance by increasing switch trial errors, as well as trials immediately following a switch trial (perseveration) and after initially making a correct switch (maintenance error). NMDA receptor blockade in the subthalamic nucleus significantly impaired performance by increasing switch errors and perseveration. Contralateral disconnection of these areas significantly reduced proactive switching accuracy by increasing switch and perseverative errors. These findings suggest that the prelimbic area and subthalamic nucleus support the use of cue information to facilitate inhibition of a previously relevant response pattern. In the second set of experiments, results of prelimbic cortex inactivation were confirmed in a second group of animals. Additionally, NMDA receptor blockade in the dorsomedial striatum resulted in an increase in switch, perseverative, and maintenance errors due to an increase in the likelihood of a rat to miss an entire block of trials. Contralateral disconnection of the prelimbic and dorsomedial striatal areas also increased all errors because of an increase in missed blocks of trials. These results suggest that the prelimbic cortex and dorsomedial striatum support the use of cue information to select and maintain a strategy throughout a block of trials. Overall, results from both sets of experiments suggest that the prelimbic cortex interacts with both the subthalamic nucleus and dorsomedial striatum in a top-down manner to execute proactive switches in behavior when cues guide strategy switches. Advisors/Committee Members: Roitman, Jamie D. (advisor), Ragozzino, Michael E. (committee member), Brown, Joel S. (committee member), Wirtshafter, David (committee member), Roitman, Mitchell F. (committee member).

Subjects/Keywords: hyperdirect pathway; prefrontal cortex; corticostriatal; disconnection; cognitive flexibility; proactive switching

10 more images…

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Baker, P. M. (2013). Contributions of the Prelimbic Cortex and Basal Ganglia Circuitry to Proactive Behavioral Switching. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/9977

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Baker, Phillip M. “Contributions of the Prelimbic Cortex and Basal Ganglia Circuitry to Proactive Behavioral Switching.” 2013. Thesis, University of Illinois – Chicago. Accessed April 16, 2021. http://hdl.handle.net/10027/9977.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Baker, Phillip M. “Contributions of the Prelimbic Cortex and Basal Ganglia Circuitry to Proactive Behavioral Switching.” 2013. Web. 16 Apr 2021.

Vancouver:

Baker PM. Contributions of the Prelimbic Cortex and Basal Ganglia Circuitry to Proactive Behavioral Switching. [Internet] [Thesis]. University of Illinois – Chicago; 2013. [cited 2021 Apr 16]. Available from: http://hdl.handle.net/10027/9977.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Baker PM. Contributions of the Prelimbic Cortex and Basal Ganglia Circuitry to Proactive Behavioral Switching. [Thesis]. University of Illinois – Chicago; 2013. Available from: http://hdl.handle.net/10027/9977

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

McMaster University

16. Akrong, James. Long-Term Potentiation and Long-Term Depression in the Corticostriatal Motor System of the Non-Anesthetized Rat.

Degree: PhD, 2009, McMaster University

URL: http://hdl.handle.net/11375/17238

►

Long-term potentiation (LTP) and depression (LTD) are activity dependent long-lasting changes in synaptic efficacy and have been proposed as mechanisms for learning and memory. Although… (more)

▼

Long-term potentiation (LTP) and depression (LTD) are activity dependent long-lasting changes in synaptic efficacy and have been proposed as mechanisms for learning and memory. Although the exact relationship of LTP and LTD to memory is not known, they do share some properties and mechanisms that relate to memory, such as the strengthening and weakening of synapses. LTP and LTD have been studied extensively in hippocampal brain-slice preparations, due to its relatively organized structure, ease of induction, and its critical function in memory storage. Less work has been done in the neocortex despite the belief that it is heavily involved in the storage of long-term memories. Activity dependent plasticity has also been demonstrated in the basal ganglia in vivo and in vitro, but the results have been somewhat inconsistent. The experiments presented in this thesis explore a novel form of neural plasticity in two excitatory pathways (corticostriatal and thalamocortical) of the basal ganglia motor loop in the intact brain in awake, freely behaving rats. In thalamocortical slice preparations, simultaneous presynaptic stimulation and postsynaptic depolarization can induce L TP in animals prior to the critical period. However the results presented in this thesis show that applied stimulation to the thalamocortical pathway failed to produce either LTP or LTD in the awake freely moving animal.Corticostriatal LTD has been shown in slice preparations following direct tetanic stimulation of the striatum. In the current experiment, cortical stimulation failed to induce LTD although there was an observable decrease in the evoked potential following low-frequency stimulation. Corticostriatal L TP has been shown to depend on the type of stimulation applied. High-frequency and theta burst stimulation produced long-lasting changes in response amplitude in the corticostriatal pathway, with theta burst stimulation appearing to be the more effective stimulation protocol for inducing LTP in both the early and late components. Paired stimulation of the substantia nigra pars compacta and cortex indicated a modulatory action of dopamine on corticostriatal synaptic plasticity. Pairing led to a stable increase in the amplitude of LTP of both early and late components. We also report that a temporal relationship exists in the striatum with respect to the release of nigral dopamine and cortical glutamate. Simultaneous stimulation produced a more robust L TP compared to the two other conditions in which there was an applied stimulation delay to either the corticostriatal or nigrostriatal pathway. The results demonstrate the mechanistic differences, not only between the thalamocortical and corticostriatal pathways, but also slice and anesthetized preparations. The results also emphasize the need for further study on mechanisms of L TP and LTD in the various excitatory and inhibitory pathways of the basal ganglia motor loop.

Thesis

Doctor of Philosophy (PhD)

Advisors/Committee Members: Racine, R. J., Psychology.

Subjects/Keywords: long term potentiation; long term depression; learning and memory; neural plasticity; basal ganglia motor loop; corticostriatal pathway; thalamocortical

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Akrong, J. (2009). Long-Term Potentiation and Long-Term Depression in the Corticostriatal Motor System of the Non-Anesthetized Rat. (Doctoral Dissertation). McMaster University. Retrieved from http://hdl.handle.net/11375/17238

Chicago Manual of Style (16^th Edition):

Akrong, James. “Long-Term Potentiation and Long-Term Depression in the Corticostriatal Motor System of the Non-Anesthetized Rat.” 2009. Doctoral Dissertation, McMaster University. Accessed April 16, 2021. http://hdl.handle.net/11375/17238.

MLA Handbook (7^th Edition):

Akrong, James. “Long-Term Potentiation and Long-Term Depression in the Corticostriatal Motor System of the Non-Anesthetized Rat.” 2009. Web. 16 Apr 2021.

Vancouver:

Akrong J. Long-Term Potentiation and Long-Term Depression in the Corticostriatal Motor System of the Non-Anesthetized Rat. [Internet] [Doctoral dissertation]. McMaster University; 2009. [cited 2021 Apr 16]. Available from: http://hdl.handle.net/11375/17238.

Council of Science Editors:

Akrong J. Long-Term Potentiation and Long-Term Depression in the Corticostriatal Motor System of the Non-Anesthetized Rat. [Doctoral Dissertation]. McMaster University; 2009. Available from: http://hdl.handle.net/11375/17238

Université de Montréal

17. Maheux, Jérôme. Mécanismes cellulaires de l'induction du facteur de transcription Nur77 après un traitement aux antipsychotiques.

Degree: 2012, Université de Montréal

URL: http://hdl.handle.net/1866/8559

Subjects/Keywords: Schizophrénie; antipsychotique; striatum; dopamine; sérotonine; D2; mGluR5; A2A; 5-HT2A; 5-HT1A; voie corticostriée; Schizophrenia; Antipsychotic drugs; serotonin; corticostriatal pathway; Health Sciences - Pharmacology / Sciences de la santé - Pharmacologie (UMI : 0419)

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Maheux, J. (2012). Mécanismes cellulaires de l'induction du facteur de transcription Nur77 après un traitement aux antipsychotiques. (Thesis). Université de Montréal. Retrieved from http://hdl.handle.net/1866/8559

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Maheux, Jérôme. “Mécanismes cellulaires de l'induction du facteur de transcription Nur77 après un traitement aux antipsychotiques.” 2012. Thesis, Université de Montréal. Accessed April 16, 2021. http://hdl.handle.net/1866/8559.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Maheux, Jérôme. “Mécanismes cellulaires de l'induction du facteur de transcription Nur77 après un traitement aux antipsychotiques.” 2012. Web. 16 Apr 2021.

Vancouver:

Maheux J. Mécanismes cellulaires de l'induction du facteur de transcription Nur77 après un traitement aux antipsychotiques. [Internet] [Thesis]. Université de Montréal; 2012. [cited 2021 Apr 16]. Available from: http://hdl.handle.net/1866/8559.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Maheux J. Mécanismes cellulaires de l'induction du facteur de transcription Nur77 après un traitement aux antipsychotiques. [Thesis]. Université de Montréal; 2012. Available from: http://hdl.handle.net/1866/8559

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

		in
And / Or
		in
And / Or
		in
And / Or
		in

Open Access Theses and Dissertations