subject:(computational modelling)

University of Cape Town

1. Rama, Ritesh Rao. Proper orthogonal decomposition with interpolation-based real-time modelling of the heart.

Degree: Image, Centre for Research in Computational and Applied Mechanics (CERECAM), 2017, University of Cape Town

► Several studies have been carried out recently with the aim of achieving cardiac modelling of the whole heart for a full heartbeat. However, within the… (more)

▼ Several studies have been carried out recently with the aim of achieving cardiac modelling of the whole heart for a full heartbeat. However, within the context of the Galerkin method, those simulations require high computational demand, ranging from 16 - 200 CPUs, and long calculation time, lasting from 1 h - 50 h. To solve this problem, this research proposes to make use of a Reduced Order Method (ROM) called the Proper Orthogonal Decomposition with Interpolation method (PODI) to achieve real-time modelling with an adequate level of solution accuracy. The idea behind this method is to first construct a database of pre-computed full-scale solutions using the Element-free Galerkin method (EFG) and then project a selected subset of these solutions to a low dimensional space. Using the Moving Least Square method (MLS), an interpolation is carried out for the problem-at-hand, before the resulting coefficients are projected back to the original high dimensional solution space. The aim of this project is to tackle real-time modelling of a patient-specific heart for a full heartbeat in different stages, namely: modelling (i) the diastolic filling with variations of material properties, (ii) the isovolumetric contraction (IVC), ejection and isovolumetric relation (IVR) with arbitrary time evolutions, and (iii) variations in heart anatomy. For the diastolic filling, computations are carried out on a bi-ventricle model (BV) to investigate the performance and accuracy for varying the material parameters. The PODI calculations of the LV are completed within 14 s on a normal desktop machine with a relative L₂-error norm of 6x10⁻³. These calculations are about 2050 times faster than EFG, with each displacement step generated at a calculation frequency of 1074 Hz. An error sensitivity analysis is consequently carried out to find the most sensitive parameter and optimum dataset to be selected for the PODI calculation. In the second phase of the research, a so-called "time standardisation scheme" is adopted to model a full heartbeat cycle. This is due to the simulation of the IVC, ejection, and IVR phases being carried out using a displacement-driven calculation method which does not use uniform simulation steps across datasets. Generated results are accurate, with the PODI calculations being 2200 faster than EFG. The PODI method is, in the third phase of this work, extended to deal with arbitrary heart meshes by developing a method called "Degrees of freedom standardisation" (DOFS). DOFS consists of using a template mesh over which all dataset result fields are projected. Once the result fields are standardised, they are consequently used for the PODI calculation, before the PODI solution is projected back to the mesh of the problem-at-hand. The first template mesh to be considered is a cube mesh. However, it is found to produce results with high errors and non-physical behaviour. The second template mesh used is a heart template. In this case, a preprocessing step is required where a non-rigid transformation based on the coherent… Advisors/Committee Members: Skatulla, Sebastian (advisor), Reddy, Daya (advisor).

Subjects/Keywords: cardiac modelling; Computational Heart Modelling

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APA (6^th Edition):

Rama, R. R. (2017). Proper orthogonal decomposition with interpolation-based real-time modelling of the heart. (Thesis). University of Cape Town. Retrieved from http://hdl.handle.net/11427/26859

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rama, Ritesh Rao. “Proper orthogonal decomposition with interpolation-based real-time modelling of the heart.” 2017. Thesis, University of Cape Town. Accessed April 15, 2021. http://hdl.handle.net/11427/26859.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rama, Ritesh Rao. “Proper orthogonal decomposition with interpolation-based real-time modelling of the heart.” 2017. Web. 15 Apr 2021.

Vancouver:

Rama RR. Proper orthogonal decomposition with interpolation-based real-time modelling of the heart. [Internet] [Thesis]. University of Cape Town; 2017. [cited 2021 Apr 15]. Available from: http://hdl.handle.net/11427/26859.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rama RR. Proper orthogonal decomposition with interpolation-based real-time modelling of the heart. [Thesis]. University of Cape Town; 2017. Available from: http://hdl.handle.net/11427/26859

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

King Abdullah University of Science and Technology

2. Abdel-Haleem, Alyaa M. Comparative metabolic modeling and analysis of human pathogens.

Degree: Biological and Environmental Sciences and Engineering (BESE) Division, 2019, King Abdullah University of Science and Technology

URL: http://hdl.handle.net/10754/656294

► Infectious diseases continue to be major health concerns worldwide. Although major advances have led to accumulation of genomic data about human pathogens, there clearly exists… (more)

Subjects/Keywords: Metabolism; Modelling; Pathogens; Computational Modelling

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APA (6^th Edition):

Abdel-Haleem, A. M. (2019). Comparative metabolic modeling and analysis of human pathogens. (Thesis). King Abdullah University of Science and Technology. Retrieved from http://hdl.handle.net/10754/656294

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Abdel-Haleem, Alyaa M. “Comparative metabolic modeling and analysis of human pathogens.” 2019. Thesis, King Abdullah University of Science and Technology. Accessed April 15, 2021. http://hdl.handle.net/10754/656294.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Abdel-Haleem, Alyaa M. “Comparative metabolic modeling and analysis of human pathogens.” 2019. Web. 15 Apr 2021.

Vancouver:

Abdel-Haleem AM. Comparative metabolic modeling and analysis of human pathogens. [Internet] [Thesis]. King Abdullah University of Science and Technology; 2019. [cited 2021 Apr 15]. Available from: http://hdl.handle.net/10754/656294.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Abdel-Haleem AM. Comparative metabolic modeling and analysis of human pathogens. [Thesis]. King Abdullah University of Science and Technology; 2019. Available from: http://hdl.handle.net/10754/656294

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Western Ontario

3. Chambers, Spencer B. The Impact of Scaphoid Malunion on Wrist Kinematics & Kinetics: A Biomechanical Investigation.

Degree: 2019, University of Western Ontario

URL: https://ir.lib.uwo.ca/etd/6707

► Scaphoid fractures are very common injuries that can have serious sequelae if pathologic healing ensues. Although there is consensus regarding the importance of a non-united… (more)

Subjects/Keywords: Scaphoid; Malunion; Biomechanics; Computational Modelling; Biomechanical modelling.

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APA (6^th Edition):

Chambers, S. B. (2019). The Impact of Scaphoid Malunion on Wrist Kinematics & Kinetics: A Biomechanical Investigation. (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/6707

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chambers, Spencer B. “The Impact of Scaphoid Malunion on Wrist Kinematics & Kinetics: A Biomechanical Investigation.” 2019. Thesis, University of Western Ontario. Accessed April 15, 2021. https://ir.lib.uwo.ca/etd/6707.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chambers, Spencer B. “The Impact of Scaphoid Malunion on Wrist Kinematics & Kinetics: A Biomechanical Investigation.” 2019. Web. 15 Apr 2021.

Vancouver:

Chambers SB. The Impact of Scaphoid Malunion on Wrist Kinematics & Kinetics: A Biomechanical Investigation. [Internet] [Thesis]. University of Western Ontario; 2019. [cited 2021 Apr 15]. Available from: https://ir.lib.uwo.ca/etd/6707.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chambers SB. The Impact of Scaphoid Malunion on Wrist Kinematics & Kinetics: A Biomechanical Investigation. [Thesis]. University of Western Ontario; 2019. Available from: https://ir.lib.uwo.ca/etd/6707

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Manitoba

4. Meggison, Brett. Anisotropic graphene.

Degree: Physics and Astronomy, 2020, University of Manitoba

URL: http://hdl.handle.net/1993/34470

► The generation of a gap in graphene has potentially useful implications for the production of electrical components. Experimentally the gapped (insulating) state has never been… (more)

Subjects/Keywords: Quantum Electrodynamics; Graphene; Computational Modelling

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APA (6^th Edition):

Meggison, B. (2020). Anisotropic graphene. (Masters Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/34470

Chicago Manual of Style (16^th Edition):

Meggison, Brett. “Anisotropic graphene.” 2020. Masters Thesis, University of Manitoba. Accessed April 15, 2021. http://hdl.handle.net/1993/34470.

MLA Handbook (7^th Edition):

Meggison, Brett. “Anisotropic graphene.” 2020. Web. 15 Apr 2021.

Vancouver:

Meggison B. Anisotropic graphene. [Internet] [Masters thesis]. University of Manitoba; 2020. [cited 2021 Apr 15]. Available from: http://hdl.handle.net/1993/34470.

Council of Science Editors:

Meggison B. Anisotropic graphene. [Masters Thesis]. University of Manitoba; 2020. Available from: http://hdl.handle.net/1993/34470

5. Marlow, Emma. Investigating the plasmonic behaviour of gold nanostructured arrays with finite element method modelling for optical sensing applications.

Degree: PhD, 2020, Queen's University Belfast

URL: https://pure.qub.ac.uk/en/theses/investigating-the-plasmonic-behaviour-of-gold-nanostructured-arrays-with-finite-element-method-modelling-for-optical-sensing-applications(ac4663ab-eac4-4ea8-ae96-80b039091d71).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.820564

► Localised surface plasmons (LSPs) exhibit striking optical behaviour with resonant properties tuned by modification of the host nanostructure’s geometry. This work utilises a novel, plasmonic… (more)

▼ Localised surface plasmons (LSPs) exhibit striking optical behaviour with resonant properties tuned by modification of the host nanostructure’s geometry. This work utilises a novel, plasmonic gold nanorod array surface as a sensing platform for diagnostic applications. Biological species were detected through the sensitivity of plasmons to refractive index changes and the binding kinetics were determined. Investigations were Lysozyme, an immune system enzyme, Proteins A and G from common bacteria and Trastuzumab (Herceptin), a breast cancer drug. Generally, the calculated kinetic coefficients were in good agreement with published values. To improve sensitivity and uniformity of the chips, the effect of surface parameters, such as diameter, height and spacing were investigated through computational modelling. Finite element method (FEM) software, COMSOL Multiphysics was used to find an optimal setup for improved sensitivity of the surface, with nanorod diameter, 35nm, height, 200nm and spacing of 40nm. The small array spacing may be difficult to fabricate so an array with nanorods of 20x150nm and spacing of 60nm may be more viable. Simulations showed field enhancements within the nanostructured array, which could be utilised for plasmon-enhanced fluorescence (PEF) to amplify the signal from fluorescent molecules. Integration of chips into a well plate produced an easy to use setup within readily available microplate readers in diagnostic laboratories. Chips were characterised, and then modelled to simulate field enhancement factors for comparison to experimental data. Enhancement factors of 2-5 were in good agreement with most experimental values, however some chips had increased experimental enhancement factors of around 20. The simulation work completed shows how surface properties, including fabrication defects and array coupling, affect the electromagnetic behaviour of the novel nanorod array surface. While the results help to improving fundamental knowledge of plasmonic interactions, simulated plasmonic spectra and local field enhancements can also be used to guide fabrication for a range of LSP applications. Additionally, the surface has been shown to be a feasible sensing platform for diagnostic applications, with in-situ monitoring through the tabletop LSPR device or through the initial PEF setup.

Subjects/Keywords: nanomaterials; computational modelling; plasmonics; gold

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APA (6^th Edition):

Marlow, E. (2020). Investigating the plasmonic behaviour of gold nanostructured arrays with finite element method modelling for optical sensing applications. (Doctoral Dissertation). Queen's University Belfast. Retrieved from https://pure.qub.ac.uk/en/theses/investigating-the-plasmonic-behaviour-of-gold-nanostructured-arrays-with-finite-element-method-modelling-for-optical-sensing-applications(ac4663ab-eac4-4ea8-ae96-80b039091d71).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.820564

Chicago Manual of Style (16^th Edition):

Marlow, Emma. “Investigating the plasmonic behaviour of gold nanostructured arrays with finite element method modelling for optical sensing applications.” 2020. Doctoral Dissertation, Queen's University Belfast. Accessed April 15, 2021. https://pure.qub.ac.uk/en/theses/investigating-the-plasmonic-behaviour-of-gold-nanostructured-arrays-with-finite-element-method-modelling-for-optical-sensing-applications(ac4663ab-eac4-4ea8-ae96-80b039091d71).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.820564.

MLA Handbook (7^th Edition):

Marlow, Emma. “Investigating the plasmonic behaviour of gold nanostructured arrays with finite element method modelling for optical sensing applications.” 2020. Web. 15 Apr 2021.

Vancouver:

Marlow E. Investigating the plasmonic behaviour of gold nanostructured arrays with finite element method modelling for optical sensing applications. [Internet] [Doctoral dissertation]. Queen's University Belfast; 2020. [cited 2021 Apr 15]. Available from: https://pure.qub.ac.uk/en/theses/investigating-the-plasmonic-behaviour-of-gold-nanostructured-arrays-with-finite-element-method-modelling-for-optical-sensing-applications(ac4663ab-eac4-4ea8-ae96-80b039091d71).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.820564.

Council of Science Editors:

Marlow E. Investigating the plasmonic behaviour of gold nanostructured arrays with finite element method modelling for optical sensing applications. [Doctoral Dissertation]. Queen's University Belfast; 2020. Available from: https://pure.qub.ac.uk/en/theses/investigating-the-plasmonic-behaviour-of-gold-nanostructured-arrays-with-finite-element-method-modelling-for-optical-sensing-applications(ac4663ab-eac4-4ea8-ae96-80b039091d71).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.820564

Cornell University

6. Agarwal, Umang. Thermodynamics And Dynamics Of Self Assembled Mesophases Of Multi-Faceted And Multi-Lobed Particles.

Degree: PhD, Chemical Engineering, 2012, Cornell University

URL: http://hdl.handle.net/1813/31499

► This work aims at developing a fundamental understanding of how shape of nano/micro-particles affects their thermodynamic phase behavior and dynamic properties. Anisotropic interaction fields encoded… (more)

▼ This work aims at developing a fundamental understanding of how shape of nano/micro-particles affects their thermodynamic phase behavior and dynamic properties. Anisotropic interaction fields encoded in nanoparticles of nonspherical shape can drive their assembly into many complex, ordered or partially ordered structures ("mesophases"). Some of these self-assembled 'phases' are highly desirable for their distinctive electronic, physical and optical properties and are very sensitive to the entropic interactions of their building blocks and other external driving fields. To understand the basic principles controlling formation of these assemblies, we performed systematic simulation studies to explore the effect of 'shape' or excluded volume interactions on the equilibrium mesophase behavior and on selected non-equilibrium mechanical properties of these systems. Monte Carlo simulations performed on a class of spacefilling polyhedral shapes predict formation of various novel liquid-crystalline (LC) and plastic-crystalline phases. By correlating these results with particle anisotropy and rotational symmetry, guidelines for predicting phase behaviour of polyhedral particles are proposed. The effect of quenched size polydispersity on the phase behavior of polyhedral particles is also elucidated by carrying out extensive compression Monte Carlo simulation for polydisperse systems of three distinct shapes. High polydispersities are found to lead to an increased stability of mesophases and the formation of jammed states at high densities. To investigate the effect of anisotropy on dynamics, we performed non-equilibrium molecular dynamics simulations to chart the yielding and shear induced melting behavior of mixed crystalline assemblies of spherical and dimer-shaped particles. Important differences in microstructure, dislocations and stress relaxation behavior emerge with introduction of this shape perturbation (dimer particles), which manifests as non- monotonic yield stress values and a two-stage shear melting behavior. Altogether this work makes some inroads toward a general understanding and taxonomy of the effect of particle shape on the thermophysical properties of colloidal assemblies. Advisors/Committee Members: Escobedo, Fernando (chair), Archer, Lynden A. (committee member), Liddell, Chekesha M (committee member).

Subjects/Keywords: phase behavior; nanoscale materials; computational modelling

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APA (6^th Edition):

Agarwal, U. (2012). Thermodynamics And Dynamics Of Self Assembled Mesophases Of Multi-Faceted And Multi-Lobed Particles. (Doctoral Dissertation). Cornell University. Retrieved from http://hdl.handle.net/1813/31499

Chicago Manual of Style (16^th Edition):

Agarwal, Umang. “Thermodynamics And Dynamics Of Self Assembled Mesophases Of Multi-Faceted And Multi-Lobed Particles.” 2012. Doctoral Dissertation, Cornell University. Accessed April 15, 2021. http://hdl.handle.net/1813/31499.

MLA Handbook (7^th Edition):

Agarwal, Umang. “Thermodynamics And Dynamics Of Self Assembled Mesophases Of Multi-Faceted And Multi-Lobed Particles.” 2012. Web. 15 Apr 2021.

Vancouver:

Agarwal U. Thermodynamics And Dynamics Of Self Assembled Mesophases Of Multi-Faceted And Multi-Lobed Particles. [Internet] [Doctoral dissertation]. Cornell University; 2012. [cited 2021 Apr 15]. Available from: http://hdl.handle.net/1813/31499.

Council of Science Editors:

Agarwal U. Thermodynamics And Dynamics Of Self Assembled Mesophases Of Multi-Faceted And Multi-Lobed Particles. [Doctoral Dissertation]. Cornell University; 2012. Available from: http://hdl.handle.net/1813/31499

Penn State University

7. Jethva, Janak Prakashchandra. Nano-scale Simulation of Gold Nanoparticle Tracking of Kinesin-1.

Degree: 2017, Penn State University

URL: https://submit-etda.libraries.psu.edu/catalog/14054jpj5113

► Kinesins are motor proteins that perform essential cellular functions such as intracellular transport along microtubules and the organization of mitotic spindle during cell division. The… (more)

▼ Kinesins are motor proteins that perform essential cellular functions such as intracellular transport along microtubules and the organization of mitotic spindle during cell division. The structure of kinesin-1 consists of two heads attached through flexible neck-linkers to a coiled-coil stalk that ends in a cargo-binding domain. Kinesin-1 derives energy from ATP hydrolysis and walks in a hand-over-hand manner with each head taking 16-nm steps along the microtubules. In published work from the Hancock lab, single molecule experiments were performed to understand the mechanochemical transitions that underlie kinesin stepping by attaching 30 nm gold nanoparticle to one of the two heads of kinesin-1 heads through a 14 amino acid Avi-tag. Using Interferometric Scattering or Dark Field Total Internal Reflection Microscopy, millisecond temporal resolution and 1 nm spatial precision were achieved in this work. Similar experiments that showed somewhat different behavior were performed by the Tomishige lab, using a PEG-tag, which is shorter and less elastic tether than an Avi-tag, and was attached at a different location on the head. Interpreting these measurements taken at millisecond timescales requires a more detailed understanding of the microsecond-scale diffusion of the kinesin head and coupled nanoparticle. Specifically, it is important to understand how the attached nanoparticle affects the dynamics of the head and whether the nanoparticle faithfully tracks the head position. To address these questions, the present study used Brownian Dynamics modelling to simulate the three-dimensional dynamics of a 30-nm nanoparticle tethered to a kinesin-1 head via either an Avi-tag or PEG-tag. In the two-head-bound state, a nanoparticle tethered by an Avi-tag tracked the head more accurately along the axis of the microtubule than a particle tethered through a PEG-tag, but tracking accuracy perpendicular to the microtubule were identical for the two tethers. In the one-head-bound state, both heads tracked nanoparticles with similar accuracy, but the PEG-tag created a larger force in the neck-linker domains than did the Avi-tag. According to these data, an Avi-tag is a better tag for tracking the head, as it more accurately tracks head position and creates less perturbation in the natural system than a PEG-tag. To better study the effects of different experimental parameters on nanoparticle tracking accuracy, a simpler model consisting of a nanoparticle tethered to a glass surface was used. In the absence of added experimental noise, particle size and contour length of the tether were found to have major effects on tracking accuracy, defined as the Root-Mean-Squared (RMS) error between imaged and true particle position, but the persistence length had only a minor influence. With simulated experimental noise added, the Avi-tag and PEG-tags gave similar RMS error of tracking, demonstrating that noise inherent in the imaging process had a larger effect on the measured particle position than did the mechanical properties of the… Advisors/Committee Members: Dr. William O. Hancock, Thesis Advisor/Co-Advisor.

Subjects/Keywords: kinesin; motor protein; computational modelling; simulation; MATLAB

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APA (6^th Edition):

Jethva, J. P. (2017). Nano-scale Simulation of Gold Nanoparticle Tracking of Kinesin-1. (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/14054jpj5113

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jethva, Janak Prakashchandra. “Nano-scale Simulation of Gold Nanoparticle Tracking of Kinesin-1.” 2017. Thesis, Penn State University. Accessed April 15, 2021. https://submit-etda.libraries.psu.edu/catalog/14054jpj5113.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jethva, Janak Prakashchandra. “Nano-scale Simulation of Gold Nanoparticle Tracking of Kinesin-1.” 2017. Web. 15 Apr 2021.

Vancouver:

Jethva JP. Nano-scale Simulation of Gold Nanoparticle Tracking of Kinesin-1. [Internet] [Thesis]. Penn State University; 2017. [cited 2021 Apr 15]. Available from: https://submit-etda.libraries.psu.edu/catalog/14054jpj5113.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jethva JP. Nano-scale Simulation of Gold Nanoparticle Tracking of Kinesin-1. [Thesis]. Penn State University; 2017. Available from: https://submit-etda.libraries.psu.edu/catalog/14054jpj5113

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Toronto

8. Kuzmic, Nikola. Modelling of Endothelial Cell Migration and Angiogenesis in Microfluidic Cell Culture Systems.

Degree: 2018, University of Toronto

URL: http://hdl.handle.net/1807/91580

►

Tumour-induced angiogenesis involves growth of new blood vessels from existing vasculature in response to signals induced by the undernourished part of tumour tissue. Due to… (more)

Subjects/Keywords: angiogenesis; computational modelling; endothelium; vasculature; 0541

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APA (6^th Edition):

Kuzmic, N. (2018). Modelling of Endothelial Cell Migration and Angiogenesis in Microfluidic Cell Culture Systems. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/91580

Chicago Manual of Style (16^th Edition):

Kuzmic, Nikola. “Modelling of Endothelial Cell Migration and Angiogenesis in Microfluidic Cell Culture Systems.” 2018. Masters Thesis, University of Toronto. Accessed April 15, 2021. http://hdl.handle.net/1807/91580.

MLA Handbook (7^th Edition):

Kuzmic, Nikola. “Modelling of Endothelial Cell Migration and Angiogenesis in Microfluidic Cell Culture Systems.” 2018. Web. 15 Apr 2021.

Vancouver:

Kuzmic N. Modelling of Endothelial Cell Migration and Angiogenesis in Microfluidic Cell Culture Systems. [Internet] [Masters thesis]. University of Toronto; 2018. [cited 2021 Apr 15]. Available from: http://hdl.handle.net/1807/91580.

Council of Science Editors:

Kuzmic N. Modelling of Endothelial Cell Migration and Angiogenesis in Microfluidic Cell Culture Systems. [Masters Thesis]. University of Toronto; 2018. Available from: http://hdl.handle.net/1807/91580

Coventry University

9. Porter, S. J. An assessment of CFD applied to a catalytic converter system with planar diffuser.

Degree: PhD, 2016, Coventry University

URL: http://curve.coventry.ac.uk/open/items/84bb21f6-7856-44a8-923e-acb5337f6a3c/1 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.699442

► Catalytic converters are widely used in the automotive industry to comply with increasingly stringent emissions regulations. The flow distribution across the catalyst substrate significantly aects… (more)

▼ Catalytic converters are widely used in the automotive industry to comply with increasingly stringent emissions regulations. The flow distribution across the catalyst substrate significantly aects its conversion eciency. Measuring the flow in a catalyst system is challenging; computational fluid dynamics (CFD) provides an alternative approach for the assessment of different design concepts and is therefore commonly employed to model flow behaviour. This thesis studies the application of CFD to modelling ow in a two-dimensional system consisting of a catalyst monolith downstream of a wide-angled planar diuser, with total included angle 60°. Computational models are developed using the commercial CFD software STAR-CCM+. Flow predictions are compared to experimental data collected by Mat Yamin, (2012) and also as part of this study. Measurements were obtained on a two-dimensional isothermal flow rig using particle image velocimetry (PIV) and hot-wire anemometry (HWA). Steady flow studies compare different methods of modelling the monolith. Models include the common approach of modelling the monolith as a porous medium and the computationally expensive individual channels model. A hybrid model is developed that combines the two approaches, benefiting from the respective merits of each method. Two monolith lengths are considered, with flow at varying Reynolds numbers. The porous model predicts the downstream velocity prole well for the shorter monolith but overpredicts flow maldistribution for the longer monolith. The inclusion of an entrance effect to account for the pressure losses associated with oblique entry into the monolith channels is studied. Best agreement in downstream velocity is observed when the pressure losses are limited using a critical angle approach. The individual channels model is found to be the most consistently accurate across monolith lengths, attributable to the accurate capture of flow behaviour upon entry into the monolith channels. A novel hybrid model is proposed, which combines the computational efficiency of the porous model with the geometrical accuracy of individual channels. The model is evaluated and is found to provide results similar to the individual channels model, with improved predictions of velocity maxima and minima. Pulsating flow studies present three transient flow regimes with similar inlet pulse shapes and varying Reynolds number and frequency. Predicted velocities in the diuser are in good agreement with PIV flow fields, however CFD predicts higher magnitudes at the shear layer. The model predicts large residual vortices present at the end of the cycle where experimental data shows none; it is concluded that CFD underpredicts turbulence diffusion. Evidence of cyclic variation in experimental data highlights the limitation of URANS turbulence models.

Subjects/Keywords: 629.25; Computational fluid dynamics; Turbulence modelling

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APA (6^th Edition):

Porter, S. J. (2016). An assessment of CFD applied to a catalytic converter system with planar diffuser. (Doctoral Dissertation). Coventry University. Retrieved from http://curve.coventry.ac.uk/open/items/84bb21f6-7856-44a8-923e-acb5337f6a3c/1 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.699442

Chicago Manual of Style (16^th Edition):

Porter, S J. “An assessment of CFD applied to a catalytic converter system with planar diffuser.” 2016. Doctoral Dissertation, Coventry University. Accessed April 15, 2021. http://curve.coventry.ac.uk/open/items/84bb21f6-7856-44a8-923e-acb5337f6a3c/1 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.699442.

MLA Handbook (7^th Edition):

Porter, S J. “An assessment of CFD applied to a catalytic converter system with planar diffuser.” 2016. Web. 15 Apr 2021.

Vancouver:

Porter SJ. An assessment of CFD applied to a catalytic converter system with planar diffuser. [Internet] [Doctoral dissertation]. Coventry University; 2016. [cited 2021 Apr 15]. Available from: http://curve.coventry.ac.uk/open/items/84bb21f6-7856-44a8-923e-acb5337f6a3c/1 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.699442.

Council of Science Editors:

Porter SJ. An assessment of CFD applied to a catalytic converter system with planar diffuser. [Doctoral Dissertation]. Coventry University; 2016. Available from: http://curve.coventry.ac.uk/open/items/84bb21f6-7856-44a8-923e-acb5337f6a3c/1 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.699442

University of Edinburgh

10. Walshe, Ross Calen. Operation of eye-movement control mechanisms during the perception of naturalistic scenes.

Degree: PhD, 2016, University of Edinburgh

URL: http://hdl.handle.net/1842/20966

► Understanding of visual scenes takes place within very brief episodes known as fixations. To explore the extent of the scene, the eye shifts between fixation… (more)

▼ Understanding of visual scenes takes place within very brief episodes known as fixations. To explore the extent of the scene, the eye shifts between fixation locations at intervals of roughly 300 ms. Currently, it is a matter of open inquiry as to what factors influence the timing of these movements. This thesis focuses on understanding the mechanisms that govern the rapid adjustment of fixation and saccade timings when novel stimulus information is encountered during a fixation. In part I, I use an experimental technique known as the fixation-contingent scene quality paradigm to control the quality of incoming visual scene information. This approach is used to assess how fixation timing adapts to moment-by-moment changes in the quality level of the stimulus. I find that quality changes tend to result in an increase in fixation durations and this occurs whether the quality is increased or decreased. Using distributional analytic techniques, I argue that these results reflect the combined influence of a rapid surprise related process and a slower acting encoding related influence. In part II, I study how fixation durations are influenced by the underlying saccade programming mechanisms. An important assumption within the eye-movement control literature is that there exists a threshold called the point-of-no-return. Once this point has been reached, a saccade may no longer be modified or cancelled. I adapt a classic psychophysical technique known as the double-step procedure to study the point-of-no-return within scene viewing tasks. I also provide a measurement of the saccadic dead time, the last point in time that a saccade may be modified. In Part III, a formal model of fixation durations in high-level tasks is presented. I build on recent modelling work and develop a formal account for the early-surprise late-encoding modulation account of fixation durations in scene viewing tasks. The model is tested against data observed in Part I of the thesis. I demonstrate that the model does a very good job of predicting these distributions with relatively few assumptions. In summary, I use experimental techniques in combination with computational modelling to reveal how a composite of low-level (saccade programming) and high-level (information processing) considerations can, and must, be taken into consideration when understanding eye-movement control behaviour in scene viewing tasks.

Subjects/Keywords: 152.14; saccades; computational modelling; perceptual decision making

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Walshe, R. C. (2016). Operation of eye-movement control mechanisms during the perception of naturalistic scenes. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/20966

Chicago Manual of Style (16^th Edition):

Walshe, Ross Calen. “Operation of eye-movement control mechanisms during the perception of naturalistic scenes.” 2016. Doctoral Dissertation, University of Edinburgh. Accessed April 15, 2021. http://hdl.handle.net/1842/20966.

MLA Handbook (7^th Edition):

Walshe, Ross Calen. “Operation of eye-movement control mechanisms during the perception of naturalistic scenes.” 2016. Web. 15 Apr 2021.

Vancouver:

Walshe RC. Operation of eye-movement control mechanisms during the perception of naturalistic scenes. [Internet] [Doctoral dissertation]. University of Edinburgh; 2016. [cited 2021 Apr 15]. Available from: http://hdl.handle.net/1842/20966.

Council of Science Editors:

Walshe RC. Operation of eye-movement control mechanisms during the perception of naturalistic scenes. [Doctoral Dissertation]. University of Edinburgh; 2016. Available from: http://hdl.handle.net/1842/20966

University of Toronto

11. Heffernan, Emily M. The Impact of Learning Sequence on Performance in a Rule-plus-exceptions Categorization Task.

Degree: 2020, University of Toronto

URL: http://hdl.handle.net/1807/103770

►

Category learning is key to successfully navigating an information-rich world. However, many categories contain exceptions that violate a general rule. Previous research has implicated hippocampus… (more)

Subjects/Keywords: Category learning; Computational modelling; Hippocampus; 0621

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APA (6^th Edition):

Heffernan, E. M. (2020). The Impact of Learning Sequence on Performance in a Rule-plus-exceptions Categorization Task. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/103770

Chicago Manual of Style (16^th Edition):

Heffernan, Emily M. “The Impact of Learning Sequence on Performance in a Rule-plus-exceptions Categorization Task.” 2020. Masters Thesis, University of Toronto. Accessed April 15, 2021. http://hdl.handle.net/1807/103770.

MLA Handbook (7^th Edition):

Heffernan, Emily M. “The Impact of Learning Sequence on Performance in a Rule-plus-exceptions Categorization Task.” 2020. Web. 15 Apr 2021.

Vancouver:

Heffernan EM. The Impact of Learning Sequence on Performance in a Rule-plus-exceptions Categorization Task. [Internet] [Masters thesis]. University of Toronto; 2020. [cited 2021 Apr 15]. Available from: http://hdl.handle.net/1807/103770.

Council of Science Editors:

Heffernan EM. The Impact of Learning Sequence on Performance in a Rule-plus-exceptions Categorization Task. [Masters Thesis]. University of Toronto; 2020. Available from: http://hdl.handle.net/1807/103770

University of Melbourne

12. ZHOU, SHOU-HAN. Human learning in visuomotor field: modeling and experimental studies.

Degree: 2015, University of Melbourne

URL: http://hdl.handle.net/11343/54663

► As the saying “practice makes perfect” goes, humans have the ability to learn from experiences. Understanding how humans learn or re-learn tasks/skills have drawn lot… (more)

Subjects/Keywords: human motor learning; computational modelling; learning strategies

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APA (6^th Edition):

ZHOU, S. (2015). Human learning in visuomotor field: modeling and experimental studies. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/54663

Chicago Manual of Style (16^th Edition):

ZHOU, SHOU-HAN. “Human learning in visuomotor field: modeling and experimental studies.” 2015. Doctoral Dissertation, University of Melbourne. Accessed April 15, 2021. http://hdl.handle.net/11343/54663.

MLA Handbook (7^th Edition):

ZHOU, SHOU-HAN. “Human learning in visuomotor field: modeling and experimental studies.” 2015. Web. 15 Apr 2021.

Vancouver:

ZHOU S. Human learning in visuomotor field: modeling and experimental studies. [Internet] [Doctoral dissertation]. University of Melbourne; 2015. [cited 2021 Apr 15]. Available from: http://hdl.handle.net/11343/54663.

Council of Science Editors:

ZHOU S. Human learning in visuomotor field: modeling and experimental studies. [Doctoral Dissertation]. University of Melbourne; 2015. Available from: http://hdl.handle.net/11343/54663

University of Sydney

13. Abeysuriya, Romesh Gerald. Physiologically-based Brain State Modeling .

Degree: 2014, University of Sydney

URL: http://hdl.handle.net/2123/14469

► The brain is the most complex organ in the body, and exhibits rich multiscale dynamics. Changes in arousal state (such as falling asleep) are accompanied… (more)

▼ The brain is the most complex organ in the body, and exhibits rich multiscale dynamics. Changes in arousal state (such as falling asleep) are accompanied by large scale changes in whole-brain dynamics that are readily observable by a range of methods including electroencephalography (EEG). However, most analysis of arousal state focuses either on coarse quantitative measures like the relative amount of power in certain frequency bands, or by assigning the state into one of several classes based largely on qualitative observations. Both of these approaches are ultimately phenomenological, and provide limited insight into the physiological mechanisms that give rise to the EEG. Predicting EEG using modeling approaches has been highly successful at relating large scale brain physiology to experimental observations. In particular, physiologically based modeling addresses significant issues that commonly arise in high-dimensional models, by constraining each parameter on the basis of experimental data, and by providing a physiologically meaningful interpretation of all model parameters. One class of brain models is based on neural field theory, which averages the properties of neurons over short temporal and spatial scales to form continuous fields that represent neural activity. These models are ideally suited to EEG comparison and analysis because the EEG reflects the combined activity of millions of individual neurons. This thesis uses an established neural field model of the brain to investigate the physiological basis for changes in the EEG over a range of brain states. In particular, the model is used to investigate sleep-wake dynamics, and newly discovered nonlinear dynamics occurring in normal brain states. In this thesis, classical sleep stages are associated with model parameters by characterizing each of them in terms of EEG power spectral features. The match between theory and experiment is quantified in terms of these spectral features. Linear interpolation of parameter values between pairs of states is used to predict changes in the EEG accompanying brain state changes. In particular, continuous parameter trajectories in the model are associated with classical, discrete sleep stage transitions. The model is fitted to EEG data from a healthy subject, and this experimentally observed trajectory is compared with predicted trajectories and with the classified regions of the model parameter space. The continuous experimental trajectory is consistent with predictions, and is able to represent the individual physiology corresponding to the experimental observations, unlike classical staging. This thesis also presents a detailed theoretical examination of nonlinear effects occurring in conjunction with sleep spindles, which are transient bursts of electrical activity during sleep that originate in the thalamus. Nonlinear effects are commonly observed in the brain during seizures, but observing nonlinearity in normal brain states is more challenging. Our neural field model predicts strong nonlinear effects…

Subjects/Keywords: Computational neuroscience; Neural field theory; Modelling

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APA (6^th Edition):

Abeysuriya, R. G. (2014). Physiologically-based Brain State Modeling . (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/14469

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Abeysuriya, Romesh Gerald. “Physiologically-based Brain State Modeling .” 2014. Thesis, University of Sydney. Accessed April 15, 2021. http://hdl.handle.net/2123/14469.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Abeysuriya, Romesh Gerald. “Physiologically-based Brain State Modeling .” 2014. Web. 15 Apr 2021.

Vancouver:

Abeysuriya RG. Physiologically-based Brain State Modeling . [Internet] [Thesis]. University of Sydney; 2014. [cited 2021 Apr 15]. Available from: http://hdl.handle.net/2123/14469.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Abeysuriya RG. Physiologically-based Brain State Modeling . [Thesis]. University of Sydney; 2014. Available from: http://hdl.handle.net/2123/14469

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Sydney

14. Zhu, Danyi. Imaging Fast Neural Activities with Electrical Impedance Tomography .

Degree: 2020, University of Sydney

URL: http://hdl.handle.net/2123/23477

► In this thesis we show impedance imaging may be used to measure neuronal activity at various stages of the visual system. Electrical Impedance Tomography (EIT)… (more)

Subjects/Keywords: Electrical Impedance Tomography; retinal electrophysiology; computational modelling

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APA (6^th Edition):

Zhu, D. (2020). Imaging Fast Neural Activities with Electrical Impedance Tomography . (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/23477

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Zhu, Danyi. “Imaging Fast Neural Activities with Electrical Impedance Tomography .” 2020. Thesis, University of Sydney. Accessed April 15, 2021. http://hdl.handle.net/2123/23477.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Zhu, Danyi. “Imaging Fast Neural Activities with Electrical Impedance Tomography .” 2020. Web. 15 Apr 2021.

Vancouver:

Zhu D. Imaging Fast Neural Activities with Electrical Impedance Tomography . [Internet] [Thesis]. University of Sydney; 2020. [cited 2021 Apr 15]. Available from: http://hdl.handle.net/2123/23477.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Zhu D. Imaging Fast Neural Activities with Electrical Impedance Tomography . [Thesis]. University of Sydney; 2020. Available from: http://hdl.handle.net/2123/23477

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Sydney

15. Guan, Davy. In silico methods for predictive toxicological and pharmacological modelling .

Degree: 2020, University of Sydney

URL: http://hdl.handle.net/2123/22914

► This thesis is concerned with the development and improvement of in silico toxicological models and will capitalise on the latest advances in predictive toxicological models… (more)

Subjects/Keywords: computational; pharmacology; toxicology; chemistry; qsar; modelling

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APA (6^th Edition):

Guan, D. (2020). In silico methods for predictive toxicological and pharmacological modelling . (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/22914

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Guan, Davy. “In silico methods for predictive toxicological and pharmacological modelling .” 2020. Thesis, University of Sydney. Accessed April 15, 2021. http://hdl.handle.net/2123/22914.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Guan, Davy. “In silico methods for predictive toxicological and pharmacological modelling .” 2020. Web. 15 Apr 2021.

Vancouver:

Guan D. In silico methods for predictive toxicological and pharmacological modelling . [Internet] [Thesis]. University of Sydney; 2020. [cited 2021 Apr 15]. Available from: http://hdl.handle.net/2123/22914.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Guan D. In silico methods for predictive toxicological and pharmacological modelling . [Thesis]. University of Sydney; 2020. Available from: http://hdl.handle.net/2123/22914

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

16. Lewis, Amy Rebecca. Performance Benefits of Customised Seating Interfaces for Elite Wheelchair Racing Athletes.

Degree: 2018, University of Adelaide

URL: http://hdl.handle.net/2440/120202

► The limited customisation in commercially available wheelchairs does not always appropriately accommodate the anthropometric variations resulting from specific impairment. Wheelchair racing athletes demonstrate up to… (more)

▼ The limited customisation in commercially available wheelchairs does not always appropriately accommodate the anthropometric variations resulting from specific impairment. Wheelchair racing athletes demonstrate up to 3.8% total body mass greater in the upper extremities, and up 9.8% total body mass reductions in their lower extremities, and between-limb asymmetries of 62.4%. As a consequence, athletes may not have the stable base of support required for optimal propulsion. The optimisation of an entire wheelchair to match unique athlete geometry is both time consuming and costly, as wheelchairs cost over $2000 each. The use of assistive technology can provide an efficient transition between the commercially available equipment and the unique athlete anthropometry. Customised seating interfaces offer a time and cost effective solution, facilitating regular modifications to satisfy athlete growth. These solutions have been used extensively in clinical applications for enhanced stress distribution and injury prevention at the seating interface; however, they have not yet been applied to sporting contexts. The goal of this research was to investigate the performance impact of customised seating interfaces on wheelchair racing propulsion technique. Supplementary goals included the development of practically viable instrumentation solutions and a musculoskeletal model representative of the unique wheelchair racing athlete anthropometries and physical capabilities to assess injury risk to analyse performance impact holistically. The research was split into four main themes: 1. Verification of the importance of the seating interface relative to other key performance parameters such as aerodynamics and glove selection. 2. Instrumentation of the hand-pushrim and seating interfaces 3. Development of a musculoskeletal model 4. Computational modelling of performance and injury risk Computational modelling was performed in the OpenSim environment which coupled kinematic inputs from 3D motion capture (VICON Bonita V16; Oxford Metrics, Oxford, United Kingdom), with kinetic inputs from a pressure mat at the seating interface (XSensor LX100; Calgary, Alberta, Canada) and inertial measurement units (IMUs) (I Measure U; New Zealand) to estimate the hand-interface interactions. This was achieved using Newton’s Second Law, incorporating athlete-specific mass data (from the analysis DXA scans), and acceleration measured from the IMU. Customised seating interfaces reduced the undesirable peak translations of the knee by up to 41.8% and lateral translation of the spine by 33.4%. These translated towards enhanced performance, with an average performance time reduction of 29.8 s (3.7% race time) in the eight international competitions following the inclusion of the customised seating interface. Additionally, athletes using cushioned seating interfaces had reduced peak pressures at the seating interface as compared to those without the interface. Instrumentation can be used outside the laboratory environments, and can, therefore, be applied in… Advisors/Committee Members: Grimshaw, Paul (advisor), Robertson, Will (advisor), Portus, Marc (advisor), School of Mechanical Engineering (school).

Subjects/Keywords: Wheelchair racing; instrumentation; computational modelling; biomechanics

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APA (6^th Edition):

Lewis, A. R. (2018). Performance Benefits of Customised Seating Interfaces for Elite Wheelchair Racing Athletes. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/120202

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lewis, Amy Rebecca. “Performance Benefits of Customised Seating Interfaces for Elite Wheelchair Racing Athletes.” 2018. Thesis, University of Adelaide. Accessed April 15, 2021. http://hdl.handle.net/2440/120202.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lewis, Amy Rebecca. “Performance Benefits of Customised Seating Interfaces for Elite Wheelchair Racing Athletes.” 2018. Web. 15 Apr 2021.

Vancouver:

Lewis AR. Performance Benefits of Customised Seating Interfaces for Elite Wheelchair Racing Athletes. [Internet] [Thesis]. University of Adelaide; 2018. [cited 2021 Apr 15]. Available from: http://hdl.handle.net/2440/120202.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lewis AR. Performance Benefits of Customised Seating Interfaces for Elite Wheelchair Racing Athletes. [Thesis]. University of Adelaide; 2018. Available from: http://hdl.handle.net/2440/120202

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Oxford

17. Hadida, Jonathan. Simulating brain resting-state activity : what matters?.

Degree: PhD, 2018, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:5abd962a-b798-4530-947a-24eeafd568f3 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.780414

► In the field of computational neuroscience, large-scale biophysical modelling is a bottom-up approach to study the interaction between brain structure and function. In this thesis,… (more)

Subjects/Keywords: Structure-function; Computational neuroscience; Computational modelling; Biophysical modelling; Complexity science; Bayesian optimisation; Neuroscience

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APA (6^th Edition):

Hadida, J. (2018). Simulating brain resting-state activity : what matters?. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:5abd962a-b798-4530-947a-24eeafd568f3 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.780414

Chicago Manual of Style (16^th Edition):

Hadida, Jonathan. “Simulating brain resting-state activity : what matters?.” 2018. Doctoral Dissertation, University of Oxford. Accessed April 15, 2021. http://ora.ox.ac.uk/objects/uuid:5abd962a-b798-4530-947a-24eeafd568f3 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.780414.

MLA Handbook (7^th Edition):

Hadida, Jonathan. “Simulating brain resting-state activity : what matters?.” 2018. Web. 15 Apr 2021.

Vancouver:

Hadida J. Simulating brain resting-state activity : what matters?. [Internet] [Doctoral dissertation]. University of Oxford; 2018. [cited 2021 Apr 15]. Available from: http://ora.ox.ac.uk/objects/uuid:5abd962a-b798-4530-947a-24eeafd568f3 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.780414.

Council of Science Editors:

Hadida J. Simulating brain resting-state activity : what matters?. [Doctoral Dissertation]. University of Oxford; 2018. Available from: http://ora.ox.ac.uk/objects/uuid:5abd962a-b798-4530-947a-24eeafd568f3 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.780414

University of Johannesburg

18. Schmitz, Walter. Computational fluid dynamics modelling of electrostatic precipitators.

Degree: 2014, University of Johannesburg

URL: http://hdl.handle.net/10210/11401

►

D.Ing. (Mechanical Engineering)

Most coal fired power stations in South Africa are equipped with Electrostatic Precipitators (ESP's). With the ongoing reduction of allowable emissions, as… (more)

▼

D.Ing. (Mechanical Engineering)

Most coal fired power stations in South Africa are equipped with Electrostatic Precipitators (ESP's). With the ongoing reduction of allowable emissions, as negotiated with the Chief Air . Pollution Control Officer (CAPCO) of the Department of Environmental Affairs and Tourism (DEAT), ways to reduce emissions are sought. In the case of emission levels exceeding the values set by the controlling authority load losses are required for compliance. This however has the effect of plant operating inefficiently and a loss of revenue will result. Specifically in times of growing demand, when more and more of the currently installed generation capacity is required to satisfy the demand, forced load reductions are not desirable. Performance enhancement of ESP's can be achieved by means of system optimisation. Research was initiated to achieve the capability of modelling important dynamic aspects of ESP performance using Computational Fluid Dynamics (CFD). This modelling capability would create the opportunity to investigate the different influencing factors which govern the dust collection efficiency. In the past ESP flow has been modelled by means of mathematical modelling with various degrees of success world-wide. It was found that the accuracy of flow modelling as presently carried outby researchers world wide, is not sufficient to represent the complex inlet flow. Commercially available performance simulation software is based on empirical modelling principles and do not include the complexity of flow fields and re-entrainment and thus results have been limited in accuracy. Computational fluid dynamics software is commercially available and widely used to simulate industrial flow for plant design and optimisation. This technology has been applied with increasing confidence and success in the past. However, often the physical phenomena relevant for the performance simulation of the plant is not integrated into the code and specialised user routines are created to achieve a valid performance model. This research study introduces a unique integrated simulation methodology based on a commercial CFD code. The work focuses on the accurate modelling of fluid flow and collection dynamics in an ESP. User subroutines have been created to simulate particle charging, collection and re-entrainment. The results of the simulations are compared to measurement at actual plant.

Subjects/Keywords: Electrostatic precipitation; Computational fluid dynamics; Computational fluid dynamics modelling

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APA (6^th Edition):

Schmitz, W. (2014). Computational fluid dynamics modelling of electrostatic precipitators. (Thesis). University of Johannesburg. Retrieved from http://hdl.handle.net/10210/11401

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Schmitz, Walter. “Computational fluid dynamics modelling of electrostatic precipitators.” 2014. Thesis, University of Johannesburg. Accessed April 15, 2021. http://hdl.handle.net/10210/11401.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Schmitz, Walter. “Computational fluid dynamics modelling of electrostatic precipitators.” 2014. Web. 15 Apr 2021.

Vancouver:

Schmitz W. Computational fluid dynamics modelling of electrostatic precipitators. [Internet] [Thesis]. University of Johannesburg; 2014. [cited 2021 Apr 15]. Available from: http://hdl.handle.net/10210/11401.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Schmitz W. Computational fluid dynamics modelling of electrostatic precipitators. [Thesis]. University of Johannesburg; 2014. Available from: http://hdl.handle.net/10210/11401

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of New South Wales

19. Tkachenko, Svetlana. Coupling of radiation and natural convection in open-ended channel in application to building-integrated photovoltaic systems.

Degree: Mechanical & Manufacturing Engineering, 2018, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/62230 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:58334/SOURCE02?view=true

► The control of temperatures of PV cells is a significant challenge in building-integrated photovoltaic (BIPV) systems. Double-skin façades provide an attractive and cost-effective solution in… (more)

▼ The control of temperatures of PV cells is a significant challenge in building-integrated photovoltaic (BIPV) systems. Double-skin façades provide an attractive and cost-effective solution in which an air gap is created between the PV modules and building wall. The objective of this thesis is to use computational simulations to improve the understanding of complex interaction of radiation with turbulent natural convective flow in the air gap and to enhance heat transfer by optimising interaction between the two mechanisms. A discrete ordinates model (DOM) for radiation transport together with a spectral line weighted sum of grey gases (SLW) model and a collocated interpolation module are adopted to evaluate the absorption properties of participating gases. As a result, wall-to-wall as well as participating gas radiation transfers are evaluated in a three-dimensional turbulent flow; the latter being calculated with a large eddy simulation (LES) formulation. Flow and thermal field development in time and space is attained to investigate the natural convection occurring in a three-dimensional vertical, open-ended, rectangular channel heated on one side which occurs in typical BIPV configurations. A parametric study with various wall emissivities with and without a participating medium is presented. Complex three-dimensional vortical structures are identified which directly affect the temperature distribution on the heated wall, suggesting that investigations of the centre plane behaviour only are not sufficient for understanding the heat transfer rates at the walls and the consequent behaviour of convective flows within the system away from the centre plane.When wall-to-wall radiation is introduced into the simulations, the unheated walls are impacted by the radiation from the heated wall. As a result, there is a very significant change in the vortical structures as well as averaged flow and thermal fields and the turbulence statistics. As the emissivity of the walls is increased the temperature of the heated wall is significantly reduced from a time and space averaged value of 62°C with the emissivity set to zero to 48°C when the emissivity of all the walls is set at 0.9. This change in the temperature can result in an increase in the efficiency of the PV cells of approximately 7%.It follows that the internal walls of BIPV systems should be lined with materials of as high an emissivity as is economically viable to optimise their efficiency and accelerate the take up by the building industry. Advisors/Committee Members: Timchenko, Victoria, Mechanical & Manufacturing Engineering, Faculty of Engineering, UNSW, Yeoh, Guan, Mechanical & Manufacturing Engineering, Faculty of Engineering, UNSW.

Subjects/Keywords: Natural convection; CFD; Renewable; Turbulence; Radiation; Computational modelling; Computational fluid dynamics

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APA (6^th Edition):

Tkachenko, S. (2018). Coupling of radiation and natural convection in open-ended channel in application to building-integrated photovoltaic systems. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/62230 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:58334/SOURCE02?view=true

Chicago Manual of Style (16^th Edition):

Tkachenko, Svetlana. “Coupling of radiation and natural convection in open-ended channel in application to building-integrated photovoltaic systems.” 2018. Doctoral Dissertation, University of New South Wales. Accessed April 15, 2021. http://handle.unsw.edu.au/1959.4/62230 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:58334/SOURCE02?view=true.

MLA Handbook (7^th Edition):

Tkachenko, Svetlana. “Coupling of radiation and natural convection in open-ended channel in application to building-integrated photovoltaic systems.” 2018. Web. 15 Apr 2021.

Vancouver:

Tkachenko S. Coupling of radiation and natural convection in open-ended channel in application to building-integrated photovoltaic systems. [Internet] [Doctoral dissertation]. University of New South Wales; 2018. [cited 2021 Apr 15]. Available from: http://handle.unsw.edu.au/1959.4/62230 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:58334/SOURCE02?view=true.

Council of Science Editors:

Tkachenko S. Coupling of radiation and natural convection in open-ended channel in application to building-integrated photovoltaic systems. [Doctoral Dissertation]. University of New South Wales; 2018. Available from: http://handle.unsw.edu.au/1959.4/62230 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:58334/SOURCE02?view=true

University of Bristol

20. Ward, Daniel. Multiscale modelling of stem cell population dynamics.

Degree: PhD, 2019, University of Bristol

URL: http://hdl.handle.net/1983/fd7b2b22-3a67-495d-9940-3ad6efd5f8a9

► Stem cells, with their propensity for pluripotency and self-regulation, have been the focus of intense research over the past decades. Understanding how the pluripotent phenotype… (more)

▼ Stem cells, with their propensity for pluripotency and self-regulation, have been the focus of intense research over the past decades. Understanding how the pluripotent phenotype is governed, across scales ranging from the cells' underlying genetic components to population-level interactions, is key to progressing from cultures of thousands of stem cells to maximal cell cultures, or entire tissues, from a small starting population. Stem cells are the precursors to all living cell types, existing during the embryonic development stage, but they can also be found throughout the bodies of all developed living creatures, for example within the bone marrow or residing at the base of an intestinal crypt. The differential behaviours of embryonic and adult stem cells, combined with complex underlying genetic regulation and environment specific dynamics, present a number of open and pressing questions. In this thesis, we present mathematical and computational modelling approaches which allow us to elucidate the key dynamics of three different stem cell populations, to shine a light on the differential effects of culture conditions on each cell type, as well as to highlight the usefulness of modelling for driving experimental research and development of culture protocols. In the first part of the thesis, we develop a delay differential equation model to capture the culture-dependent dynamics of a homogeneous population of human haematopoietic stem cells, and show that a key culture protocol component, epo, has two response phases in which it differentially affects cell proliferation and differentiation. In the second part, we introduce agent-based modelling as a method for capturing the population dynamics of mouse embryonic stem cells (mESCs) in different culture conditions. We showed that linking the MycN component of the mESC gene regulatory network to the cell cycle captures both the subcellular distributions of key proteins and growth dynamics in vitro. Finally, we develop a multiscale agent-based model of intestinal crypts, that couples ordinary differential equation modelling of subcellular kinetics to a cell-based description of cell movement, proliferation, and contact inhibition (CI). This enables us to recapitulate tissue level dynamics of intestinal crypts, as well as to present an alternative approach to describing the formation of the Wnt expression gradient. We showed that cross-talk between the Hippo and Wnt signalling pathways is able to affect CI and that CI is likely significantly reduced in intestinal crypt mutations. Together, this research shows the effectiveness of modelling, across physical and temporal scales, to recapitulate in vitro and in vivo stem cell dynamics, as well as to capture the contributions of key behaviours such as proliferation and differentiation to healthy and dysplastic population growth.

Subjects/Keywords: 620; Multiscale modelling; Agent-based modelling; Computational biology; Mathematical biology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ward, D. (2019). Multiscale modelling of stem cell population dynamics. (Doctoral Dissertation). University of Bristol. Retrieved from http://hdl.handle.net/1983/fd7b2b22-3a67-495d-9940-3ad6efd5f8a9

Chicago Manual of Style (16^th Edition):

Ward, Daniel. “Multiscale modelling of stem cell population dynamics.” 2019. Doctoral Dissertation, University of Bristol. Accessed April 15, 2021. http://hdl.handle.net/1983/fd7b2b22-3a67-495d-9940-3ad6efd5f8a9.

MLA Handbook (7^th Edition):

Ward, Daniel. “Multiscale modelling of stem cell population dynamics.” 2019. Web. 15 Apr 2021.

Vancouver:

Ward D. Multiscale modelling of stem cell population dynamics. [Internet] [Doctoral dissertation]. University of Bristol; 2019. [cited 2021 Apr 15]. Available from: http://hdl.handle.net/1983/fd7b2b22-3a67-495d-9940-3ad6efd5f8a9.

Council of Science Editors:

Ward D. Multiscale modelling of stem cell population dynamics. [Doctoral Dissertation]. University of Bristol; 2019. Available from: http://hdl.handle.net/1983/fd7b2b22-3a67-495d-9940-3ad6efd5f8a9

University of Bristol

21. Ward, Daniel. Multiscale modelling of stem cell population dynamics.

Degree: PhD, 2019, University of Bristol

URL: https://research-information.bris.ac.uk/en/studentTheses/fd7b2b22-3a67-495d-9940-3ad6efd5f8a9 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.774445

► Stem cells, with their propensity for pluripotency and self-regulation, have been the focus of intense research over the past decades. Understanding how the pluripotent phenotype… (more)

▼ Stem cells, with their propensity for pluripotency and self-regulation, have been the focus of intense research over the past decades. Understanding how the pluripotent phenotype is governed, across scales ranging from the cells' underlying genetic components to population-level interactions, is key to progressing from cultures of thousands of stem cells to maximal cell cultures, or entire tissues, from a small starting population. Stem cells are the precursors to all living cell types, existing during the embryonic development stage, but they can also be found throughout the bodies of all developed living creatures, for example within the bone marrow or residing at the base of an intestinal crypt. The differential behaviours of embryonic and adult stem cells, combined with complex underlying genetic regulation and environment specific dynamics, present a number of open and pressing questions. In this thesis, we present mathematical and computational modelling approaches which allow us to elucidate the key dynamics of three different stem cell populations, to shine a light on the differential effects of culture conditions on each cell type, as well as to highlight the usefulness of modelling for driving experimental research and development of culture protocols. In the first part of the thesis, we develop a delay differential equation model to capture the culture-dependent dynamics of a homogeneous population of human haematopoietic stem cells, and show that a key culture protocol component, epo, has two response phases in which it differentially affects cell proliferation and differentiation. In the second part, we introduce agent-based modelling as a method for capturing the population dynamics of mouse embryonic stem cells (mESCs) in different culture conditions. We showed that linking the MycN component of the mESC gene regulatory network to the cell cycle captures both the subcellular distributions of key proteins and growth dynamics in vitro. Finally, we develop a multiscale agent-based model of intestinal crypts, that couples ordinary differential equation modelling of subcellular kinetics to a cell-based description of cell movement, proliferation, and contact inhibition (CI). This enables us to recapitulate tissue level dynamics of intestinal crypts, as well as to present an alternative approach to describing the formation of the Wnt expression gradient. We showed that cross-talk between the Hippo and Wnt signalling pathways is able to affect CI and that CI is likely significantly reduced in intestinal crypt mutations. Together, this research shows the effectiveness of modelling, across physical and temporal scales, to recapitulate in vitro and in vivo stem cell dynamics, as well as to capture the contributions of key behaviours such as proliferation and differentiation to healthy and dysplastic population growth.

Subjects/Keywords: 620; Multiscale modelling; Agent-based modelling; Computational biology; Mathematical biology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ward, D. (2019). Multiscale modelling of stem cell population dynamics. (Doctoral Dissertation). University of Bristol. Retrieved from https://research-information.bris.ac.uk/en/studentTheses/fd7b2b22-3a67-495d-9940-3ad6efd5f8a9 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.774445

Chicago Manual of Style (16^th Edition):

Ward, Daniel. “Multiscale modelling of stem cell population dynamics.” 2019. Doctoral Dissertation, University of Bristol. Accessed April 15, 2021. https://research-information.bris.ac.uk/en/studentTheses/fd7b2b22-3a67-495d-9940-3ad6efd5f8a9 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.774445.

MLA Handbook (7^th Edition):

Ward, Daniel. “Multiscale modelling of stem cell population dynamics.” 2019. Web. 15 Apr 2021.

Vancouver:

Ward D. Multiscale modelling of stem cell population dynamics. [Internet] [Doctoral dissertation]. University of Bristol; 2019. [cited 2021 Apr 15]. Available from: https://research-information.bris.ac.uk/en/studentTheses/fd7b2b22-3a67-495d-9940-3ad6efd5f8a9 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.774445.

Council of Science Editors:

Ward D. Multiscale modelling of stem cell population dynamics. [Doctoral Dissertation]. University of Bristol; 2019. Available from: https://research-information.bris.ac.uk/en/studentTheses/fd7b2b22-3a67-495d-9940-3ad6efd5f8a9 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.774445

University of Manchester

22. Jones, Gareth. Development of Ventricular Cell Models for the Study of Alternans, Heart Failure and Energetic Impairment.

Degree: 2018, University of Manchester

URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:315536

► In this thesis the changes observed in human ventricular cells with disease are examined. As heart disease remains one of the leading causes of death… (more)

Subjects/Keywords: Cardiac modelling; Cardiac disease; Computational Modelling; Biophysics; Ion Channels; HCM

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Jones, G. (2018). Development of Ventricular Cell Models for the Study of Alternans, Heart Failure and Energetic Impairment. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:315536

Chicago Manual of Style (16^th Edition):

Jones, Gareth. “Development of Ventricular Cell Models for the Study of Alternans, Heart Failure and Energetic Impairment.” 2018. Doctoral Dissertation, University of Manchester. Accessed April 15, 2021. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:315536.

MLA Handbook (7^th Edition):

Jones, Gareth. “Development of Ventricular Cell Models for the Study of Alternans, Heart Failure and Energetic Impairment.” 2018. Web. 15 Apr 2021.

Vancouver:

Jones G. Development of Ventricular Cell Models for the Study of Alternans, Heart Failure and Energetic Impairment. [Internet] [Doctoral dissertation]. University of Manchester; 2018. [cited 2021 Apr 15]. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:315536.

Council of Science Editors:

Jones G. Development of Ventricular Cell Models for the Study of Alternans, Heart Failure and Energetic Impairment. [Doctoral Dissertation]. University of Manchester; 2018. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:315536

University of Manchester

23. Jones, Gareth. Development of ventricular cell models for the study of alternans, heart failure and energetic impairment.

Degree: PhD, 2018, University of Manchester

URL: https://www.research.manchester.ac.uk/portal/en/theses/development-of-ventricular-cell-models-for-the-study-of-alternans-heart-failure-and-energetic-impairment(f3d73dc8-47e2-4f40-a9a1-5a89dd2ecdf0).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.823095

► In this thesis the changes observed in human ventricular cells with disease are examined. As heart disease remains one of the leading causes of death… (more)

Subjects/Keywords: Ion Channels; HCM; Biophysics; Computational Modelling; Cardiac disease; Cardiac modelling

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Jones, G. (2018). Development of ventricular cell models for the study of alternans, heart failure and energetic impairment. (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/development-of-ventricular-cell-models-for-the-study-of-alternans-heart-failure-and-energetic-impairment(f3d73dc8-47e2-4f40-a9a1-5a89dd2ecdf0).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.823095

Chicago Manual of Style (16^th Edition):

Jones, Gareth. “Development of ventricular cell models for the study of alternans, heart failure and energetic impairment.” 2018. Doctoral Dissertation, University of Manchester. Accessed April 15, 2021. https://www.research.manchester.ac.uk/portal/en/theses/development-of-ventricular-cell-models-for-the-study-of-alternans-heart-failure-and-energetic-impairment(f3d73dc8-47e2-4f40-a9a1-5a89dd2ecdf0).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.823095.

MLA Handbook (7^th Edition):

Jones, Gareth. “Development of ventricular cell models for the study of alternans, heart failure and energetic impairment.” 2018. Web. 15 Apr 2021.

Vancouver:

Jones G. Development of ventricular cell models for the study of alternans, heart failure and energetic impairment. [Internet] [Doctoral dissertation]. University of Manchester; 2018. [cited 2021 Apr 15]. Available from: https://www.research.manchester.ac.uk/portal/en/theses/development-of-ventricular-cell-models-for-the-study-of-alternans-heart-failure-and-energetic-impairment(f3d73dc8-47e2-4f40-a9a1-5a89dd2ecdf0).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.823095.

Council of Science Editors:

Jones G. Development of ventricular cell models for the study of alternans, heart failure and energetic impairment. [Doctoral Dissertation]. University of Manchester; 2018. Available from: https://www.research.manchester.ac.uk/portal/en/theses/development-of-ventricular-cell-models-for-the-study-of-alternans-heart-failure-and-energetic-impairment(f3d73dc8-47e2-4f40-a9a1-5a89dd2ecdf0).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.823095

Universitat Politècnica de València

24. López Pérez, Alejandro Daniel. Computational modelling of the human heart and multiscale simulation of its electrophysiological activity aimed at the treatment of cardiac arrhythmias related to ischaemia and Infarction .

Degree: 2019, Universitat Politècnica de València

URL: http://hdl.handle.net/10251/124973

► [ES] Las enfermedades cardiovasculares constituyen la principal causa de morbilidad y mortalidad a nivel mundial, causando en torno a 18 millones de muertes cada año.… (more)

▼ [ES] Las enfermedades cardiovasculares constituyen la principal causa de morbilidad y mortalidad a nivel mundial, causando en torno a 18 millones de muertes cada año. De entre ellas, la más común es la enfermedad isquémica cardíaca, habitualmente denominada como infarto de miocardio (IM). Tras superar un IM, un considerable número de pacientes desarrollan taquicardias ventriculares (TV) potencialmente mortales durante la fase crónica del IM, es decir, semanas, meses o incluso años después la fase aguda inicial. Este tipo concreto de TV normalmente se origina por una reentrada a través de canales de conducción (CC), filamentos de miocardio superviviente que atraviesan la cicatriz del infarto fibrosa y no conductora. Cuando los fármacos anti-arrítmicos resultan incapaces de evitar episodios recurrentes de TV, la ablación por radiofrecuencia (ARF), un procedimiento mínimamente invasivo realizado mediante cateterismo en el laboratorio de electrofisiología (EF), se usa habitualmente para interrumpir de manera permanente la propagación eléctrica a través de los CCs responsables de la TV. Sin embargo, además de ser invasivo, arriesgado y requerir mucho tiempo, en casos de TVs relacionadas con IM crónico, hasta un 50% de los pacientes continúa padeciendo episodios recurrentes de TV tras el procedimiento de ARF. Por tanto, existe la necesidad de desarrollar nuevas estrategias pre-procedimiento para mejorar la planificación de la ARF y, de ese modo, aumentar esta tasa de éxito relativamente baja. En primer lugar, realizamos una revisión exhaustiva de la literatura referente a los modelos cardiacos 3D existentes, con el fin de obtener un profundo conocimiento de sus principales características y los métodos usados en su construcción, con especial atención sobre los modelos orientados a simulación de EF cardíaca. Luego, usando datos clínicos de un paciente con historial de TV relacionada con infarto, diseñamos e implementamos una serie de estrategias y metodologías para (1) generar modelos computacionales 3D específicos de paciente de ventrículos infartados que puedan usarse para realizar simulaciones de EF cardíaca a nivel de órgano, incluyendo la cicatriz del infarto y la región circundante conocida como zona de borde (ZB); (2) construir modelos 3D de torso que permitan la obtención del ECG simulado; y (3) llevar a cabo estudios in-silico de EF personalizados y pre-procedimiento, tratando de replicar los verdaderos estudios de EF realizados en el laboratorio de EF antes de la ablación. La finalidad de estas metodologías es la de localizar los CCs en el modelo ventricular 3D para ayudar a definir los objetivos de ablación óptimos para el procedimiento de ARF. Por último, realizamos el estudio retrospectivo por simulación de un caso, en el que logramos inducir la TV reentrante relacionada con el infarto usando diferentes configuraciones de modelado para la ZB. Validamos nuestros resultados mediante la reproducción, con una precisión razonable, del ECG del paciente en TV, así como en ritmo sinusal a partir de los mapas de… Advisors/Committee Members: Ferrero De Loma-Osorio, José María (advisor), Sebastián Aguilar, Rafael (advisor).

Subjects/Keywords: Myocardial infarction; Ventricular tachycardia; Radiofrequency ablation; Computational cardiology; Cardiac computational electrophysiology; Computational modelling; Computer simulation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

López Pérez, A. D. (2019). Computational modelling of the human heart and multiscale simulation of its electrophysiological activity aimed at the treatment of cardiac arrhythmias related to ischaemia and Infarction . (Doctoral Dissertation). Universitat Politècnica de València. Retrieved from http://hdl.handle.net/10251/124973

Chicago Manual of Style (16^th Edition):

López Pérez, Alejandro Daniel. “Computational modelling of the human heart and multiscale simulation of its electrophysiological activity aimed at the treatment of cardiac arrhythmias related to ischaemia and Infarction .” 2019. Doctoral Dissertation, Universitat Politècnica de València. Accessed April 15, 2021. http://hdl.handle.net/10251/124973.

MLA Handbook (7^th Edition):

López Pérez, Alejandro Daniel. “Computational modelling of the human heart and multiscale simulation of its electrophysiological activity aimed at the treatment of cardiac arrhythmias related to ischaemia and Infarction .” 2019. Web. 15 Apr 2021.

Vancouver:

López Pérez AD. Computational modelling of the human heart and multiscale simulation of its electrophysiological activity aimed at the treatment of cardiac arrhythmias related to ischaemia and Infarction . [Internet] [Doctoral dissertation]. Universitat Politècnica de València; 2019. [cited 2021 Apr 15]. Available from: http://hdl.handle.net/10251/124973.

Council of Science Editors:

López Pérez AD. Computational modelling of the human heart and multiscale simulation of its electrophysiological activity aimed at the treatment of cardiac arrhythmias related to ischaemia and Infarction . [Doctoral Dissertation]. Universitat Politècnica de València; 2019. Available from: http://hdl.handle.net/10251/124973

25. Ghiasi, Golnoush. Simulation of turbulent flames at conditions related to IC engines.

Degree: PhD, 2018, University of Cambridge

URL: https://doi.org/10.17863/CAM.25396 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.753372

► Engine manufacturers are constantly seeking avenues to build cleaner and more ef cient engines to meet ever increasing stringent emission legislations. This requires a closer… (more)

▼ Engine manufacturers are constantly seeking avenues to build cleaner and more ef cient engines to meet ever increasing stringent emission legislations. This requires a closer under- standing of the in-cylinder physical and chemical processes, which can be obtained either through experiments or simulations. The advent of computational hardware, methodologies and modelling approaches in recent times make computational uid dynamics (CFD) an important and cost-effective tool for gathering required insights on the in-cylinder ow, combustion and their interactions. Traditional Reynolds-Averaged Navier-Stokes (RANS) methods and emerging Large Eddy Simulation (LES) techniques are being used as a reli- able mathematical framework tools for the prediction of turbulent ow in such conditions. Nonetheless, the combustion submodels commonly used in combustion calculations are developed using insights and results obtained for atmospheric conditions. However, The combustion characteristics and its interaction with turbulence at Internal combustion (IC) engine conditions with, high pressure and temperatures can be quite different from those in conventional conditions and are yet to be investigated in detail. The objective here is to apply FlaRe (Flamelets revised for physical consistencies) model for IC engines conditions and assess its performance. This model was developed in earlier studies for continuous combustion systems. It is well accepted that the laminar burning velocity, SL, is an essential parameter to determine the fuel burn rate and consequently the power output and ef ciency of IC engines. Also, it is involved in almost all of the sophisticated turbulent combustion models for premixed and partially premixed charges. The burning velocities of these mixtures at temperatures of 850 ≤ T ≤ 950 decrease with pressure up to about 3 MPa as it is well known, but it starts to increase beyond this pressure. This contrasting behaviour observed for the rst time is explained and it is related to the role of pressure dependent reaction for iso-octane and involving OH and the in uence of this radical on the fuel consumption rate. The results iv seem to suggest that the overall order of the combustion reaction for iso-octane and gasoline mixture with air is larger than 2 at pressures higher than 3 MPa. The FlaRe combustion is used to simulate premixed combustion inside a spark-ignition engine. The predictive capabilities of the proposed approach and sensitivity of the model to various parameters have been studied. FlaRe approach includes a parameter βc representing the effects of ame curvature on the burning rate. Since the reactant temperature and pressure inside the cylinder are continually varying with time, the mutual in uence of ame curvature and thermo-chemical activities may be stronger in IC engines and thus this parameter is less likely to be constant. The sensitivity of engine simulation results to this parameter is investigated for a range of engine speed and load conditions. The results indicate some sensitivity and so a…

Subjects/Keywords: 621.43; Combustion Modelling; IC Engine; Mathematical Modelling; Computational Fluid Mechanics; CFD; Statistical Modelling; Combustion Scinece

10 more images…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ghiasi, G. (2018). Simulation of turbulent flames at conditions related to IC engines. (Doctoral Dissertation). University of Cambridge. Retrieved from https://doi.org/10.17863/CAM.25396 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.753372

Chicago Manual of Style (16^th Edition):

Ghiasi, Golnoush. “Simulation of turbulent flames at conditions related to IC engines.” 2018. Doctoral Dissertation, University of Cambridge. Accessed April 15, 2021. https://doi.org/10.17863/CAM.25396 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.753372.

MLA Handbook (7^th Edition):

Ghiasi, Golnoush. “Simulation of turbulent flames at conditions related to IC engines.” 2018. Web. 15 Apr 2021.

Vancouver:

Ghiasi G. Simulation of turbulent flames at conditions related to IC engines. [Internet] [Doctoral dissertation]. University of Cambridge; 2018. [cited 2021 Apr 15]. Available from: https://doi.org/10.17863/CAM.25396 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.753372.

Council of Science Editors:

Ghiasi G. Simulation of turbulent flames at conditions related to IC engines. [Doctoral Dissertation]. University of Cambridge; 2018. Available from: https://doi.org/10.17863/CAM.25396 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.753372

University of Stirling

26. McGuinness, James. Implications of Potassium Channel Heterogeneity for Model Vestibulo-Ocular Reflex Response Fidelity.

Degree: PhD, 2014, University of Stirling

URL: http://hdl.handle.net/1893/21844

► The Vestibulo-Ocular Reflex (VOR) produces compensatory eye movements in response to head and body rotations movements, over a wide range of frequencies and in a… (more)

▼ The Vestibulo-Ocular Reflex (VOR) produces compensatory eye movements in response to head and body rotations movements, over a wide range of frequencies and in a variety of dimensions. The individual components of the VOR are separated into parallel pathways, each dealing with rotations or movements in individual planes or axes. The Horizontal VOR (hVOR) compensates for eye movements in the Horizontal plane, and comprises a linear and non-linear pathway. The linear pathway of the hVOR provides fast and accurate compensation for rotations, the response being produced through 3-neuron arc, producing a direct translation of detected head velocity to compensatory eye velocity. However, single neurons involved in the middle stage of this 3-neuron arc cannot account for the wide frequency over which the reflex compensates, and the response is produced through the population response of the Medial Vestibular Nucleus (MVN) neurons involved. Population Heterogeneity likely plays a role in the production of high fidelity population response, especially for high frequency rotations. Here we present evidence that, in populations of bio-physical compartmental models of the MVN neurons involved, Heterogeneity across the population, in the form of diverse spontaneous firing rates, improves the response fidelity of the population over Homogeneous populations. Further, we show that the specific intrinsic membrane properties that give rise to this Heterogeneity may be the diversity of certain slow voltage activated Potassium conductances of the neurons. We show that Heterogeneous populations perform significantly better than Homogeneous populations, for a wide range of input amplitudes and frequencies, producing a much higher fidelity response. We propose that variance of Potassium conductances provides a plausible biological means by which Heterogeneity arises, and that the Heterogeneity plays an important functional role in MVN neuron population responses. We discuss our findings in relation to the specific mechanism of Desynchronisation through which the benfits of Heterogeneity may arise, and place those findings in the context of previous work on Heterogeneity both in general neural processing, and the VOR in particular. Interesting findings regarding the emergence of phase leads are also discussed, as well as suggestions for future work, looking further at Heterogeneity of MVN neuron populations.

Subjects/Keywords: Computational Neuroscience; Compartmental Modelling; Potassium Channels; Population Modelling; Vestibulo-Ocular Reflex; Ion Channel Modelling; Computational neuroscience; Vestibulo-ocular reflex; Potassium channels

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

McGuinness, J. (2014). Implications of Potassium Channel Heterogeneity for Model Vestibulo-Ocular Reflex Response Fidelity. (Doctoral Dissertation). University of Stirling. Retrieved from http://hdl.handle.net/1893/21844

Chicago Manual of Style (16^th Edition):

McGuinness, James. “Implications of Potassium Channel Heterogeneity for Model Vestibulo-Ocular Reflex Response Fidelity.” 2014. Doctoral Dissertation, University of Stirling. Accessed April 15, 2021. http://hdl.handle.net/1893/21844.

MLA Handbook (7^th Edition):

McGuinness, James. “Implications of Potassium Channel Heterogeneity for Model Vestibulo-Ocular Reflex Response Fidelity.” 2014. Web. 15 Apr 2021.

Vancouver:

McGuinness J. Implications of Potassium Channel Heterogeneity for Model Vestibulo-Ocular Reflex Response Fidelity. [Internet] [Doctoral dissertation]. University of Stirling; 2014. [cited 2021 Apr 15]. Available from: http://hdl.handle.net/1893/21844.

Council of Science Editors:

McGuinness J. Implications of Potassium Channel Heterogeneity for Model Vestibulo-Ocular Reflex Response Fidelity. [Doctoral Dissertation]. University of Stirling; 2014. Available from: http://hdl.handle.net/1893/21844

University of New South Wales

27. Castilla Rho, Juan Carlos. Agent-based modelling of groundwater systems.

Degree: Civil & Environmental Engineering, 2017, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/60461 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:52285/SOURCE02?view=true

► Groundwater plays a vital role in sustaining ecosystems, food and water security, and will aid human adaptation to climate change.Scenario-based modelling can make unrealistic long-term… (more)

▼ Groundwater plays a vital role in sustaining ecosystems, food and water security, and will aid human adaptation to climate change.Scenario-based modelling can make unrealistic long-term forecasts as the two-way feedbacks between social and hydrogeologicalsystems are not explicitly included. The goal of this thesis is to develop a modelling framework that enables interdisciplinary,transparent, and collaborative model-based assessments that capture the coevolution of coupled systems of people and groundwater.To achieve this goal, principles of agent-based modelling and complex systems were adapted to groundwater problems, as a novelapproach to combine socio-economic and groundwater flow modelling. FlowLogo, a new software based on a finite-difference solutionto the governing equation of groundwater flow implemented in NetLogo, a widely-used open-source ABM platform, is introduced. Itscapabilities are demonstrated using a hypothetical groundwater management problem and scenario analysis of a suite of policy leversand agent traits. Opportunities and limitations of using FlowLogo as a decision-support tool in a number of groundwater hotspots arediscussed. We further test and demonstrate the use of FlowLogo through the “Groundwater Commons Game” (GCG), an agent-basedmodel of irrigated agriculture rooted in principles of human cooperation and collective action, grounded on the largest dataset ofcultural values in existence—The World Values Survey 6. Using this model, we simulate the long-term efficacy of groundwaterconservation policies in three major aquifer systems currently facing unsustainable demands—the Punjab (India/Pakistan), the CentralValley (USA) and the Murray-Darling Basin (Australia). These simulations reveal 'tipping points' where collective attitudes towardsgroundwater conservation shift abruptly with changes in cultural values and enforcement provisions. A second study examines thetemporal dynamics of social norms and advances our understanding of the factors that may accelerate transitions to regulatorycompliance, such strategies used to enforce and promote compliance and the prevalence of role models. Finally, the foundations forparticipatory groundwater modelling are proposed, where scientists and stakeholders may interact with live computational experimentsto test policy interventions and evaluate solutions. Advisors/Committee Members: Andersen, Martin, Civil & Environmental Engineering, Faculty of Engineering, UNSW.

Subjects/Keywords: Computational social science; Agent-based modelling; Groundwater management; Complex adaptive systems; Participatory modelling; Groundwater commons

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APA (6^th Edition):

Castilla Rho, J. C. (2017). Agent-based modelling of groundwater systems. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/60461 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:52285/SOURCE02?view=true

Chicago Manual of Style (16^th Edition):

Castilla Rho, Juan Carlos. “Agent-based modelling of groundwater systems.” 2017. Doctoral Dissertation, University of New South Wales. Accessed April 15, 2021. http://handle.unsw.edu.au/1959.4/60461 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:52285/SOURCE02?view=true.

MLA Handbook (7^th Edition):

Castilla Rho, Juan Carlos. “Agent-based modelling of groundwater systems.” 2017. Web. 15 Apr 2021.

Vancouver:

Castilla Rho JC. Agent-based modelling of groundwater systems. [Internet] [Doctoral dissertation]. University of New South Wales; 2017. [cited 2021 Apr 15]. Available from: http://handle.unsw.edu.au/1959.4/60461 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:52285/SOURCE02?view=true.

Council of Science Editors:

Castilla Rho JC. Agent-based modelling of groundwater systems. [Doctoral Dissertation]. University of New South Wales; 2017. Available from: http://handle.unsw.edu.au/1959.4/60461 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:52285/SOURCE02?view=true

28. Rehman, Usman. Next generation bioreactor models for wastewater treatment systems by means of detailed combined modelling of mixing and biokinetics.

Degree: 2016, Ghent University

URL: http://hdl.handle.net/1854/LU-8109100

► Wastewater treatment plants (WWTP) are needed to treat municipal wastewater to reduce the impact of pollutants on the environment and the ambient nature. The discharge… (more)

▼ Wastewater treatment plants (WWTP) are needed to treat municipal wastewater to reduce the impact of pollutants on the environment and the ambient nature. The discharge of treated wastewater and the disposal of sludge from treatment plants treating domestic or industrial wastewater are subject to regulations imposed by the authorities. Moreover, during the wastewater treatment process greenhouse gas emissions are produced. These emissions from WWTPs are a matter of growing concern. The increased importance of wastewater treatment has led to development of mathematical models for optimization and design of wastewater treatment plants. WWTP modelling entails the modelling of the biological reactions (biokinetics) and underlying flow physics of the bioreactors (hydrodynamics). Currently, to model the hydrodynamics of a bioreactor, the tanks-in-series (TIS) modelling approach, which at best can model the flow variations in one direction, is widely used. These models assume a bioreactor as a series of completely mixed tanks and, hence, ignore any variation in the concentrations stemming from the design of a bioreactor or operational conditions. Therefore, these models eventually need rigorous calibration efforts to match measurements. This calibration is generally performed by manipulating kinetic parameters such as half saturation indices (K-values). The calibrated models are then used to assess or formulate different control strategies which includes the determination of an appropriate sensor location and a well-chosen setpoint for the controllers. In addition, the calibrated models are then extrapolated to predict the WWTP performance under different dynamic conditions (diurnal and dry/wet weather conditions) assuming that the flow patterns remain unchanged. In this thesis, it is hypothesised and confirmed that the bioreactors are not at all completely mixed and, hence, current models wrongfully calibrate the kinetic parameters by correcting for the errors induced by the over-simplified modelling of mixing. Consequently, the need for re-calibration arises at different operational conditions due to the limitation of the current models to incorporate changes in operational conditions. The thesis comprises of four parts. The first part provides the detailed account of CFD (computational fluid dynamics) modelling of WWTPs. Second part is about integration of CFD hydrodynamic models with the biokinetic models to evaluate the impact of mixing on the process performance. Third part is about model reduction, where detailed knowledge gained from the CFD-biokinetic modelling is used to develop simple but spatially localized compartmental model. The fourth part provides the insight about impact of mixing on the TIS model calibrations. In the first part, detailed CFD hydrodynamic modelling of a bioreactor of Eindhoven WWTP is performed. The impact of reactor configuration and process conditions on gas dispersion is observed. Potential regions of poor mixing are identified. The different flow patterns are discussed in detail.… Advisors/Committee Members: Nopens, Ingmar, Amerlinck, Youri.

Subjects/Keywords: Earth and Environmental Sciences; wastewater treatment modelling; Computational fluid dynamics; compartmental modelling

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APA (6^th Edition):

Rehman, U. (2016). Next generation bioreactor models for wastewater treatment systems by means of detailed combined modelling of mixing and biokinetics. (Thesis). Ghent University. Retrieved from http://hdl.handle.net/1854/LU-8109100

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rehman, Usman. “Next generation bioreactor models for wastewater treatment systems by means of detailed combined modelling of mixing and biokinetics.” 2016. Thesis, Ghent University. Accessed April 15, 2021. http://hdl.handle.net/1854/LU-8109100.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rehman, Usman. “Next generation bioreactor models for wastewater treatment systems by means of detailed combined modelling of mixing and biokinetics.” 2016. Web. 15 Apr 2021.

Vancouver:

Rehman U. Next generation bioreactor models for wastewater treatment systems by means of detailed combined modelling of mixing and biokinetics. [Internet] [Thesis]. Ghent University; 2016. [cited 2021 Apr 15]. Available from: http://hdl.handle.net/1854/LU-8109100.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rehman U. Next generation bioreactor models for wastewater treatment systems by means of detailed combined modelling of mixing and biokinetics. [Thesis]. Ghent University; 2016. Available from: http://hdl.handle.net/1854/LU-8109100

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Windsor

29. Shademan, Mehrdad. CFD Simulation of Impinging Jet Flows and Boiling Heat Transfer.

Degree: PhD, Mechanical, Automotive, and Materials Engineering, 2015, University of Windsor

URL: http://scholar.uwindsor.ca/etd/5700

► Circular jets impinging vertically on flat surfaces have many practical applications in industry. Nozzle height-to-diameter ratio plays an important role in the performance of this… (more)

▼ Circular jets impinging vertically on flat surfaces have many practical applications in industry. Nozzle height-to-diameter ratio plays an important role in the performance of this type of jet. In this thesis a step by step approach has been followed to cover different aspects of impinging jets. In the first step, a steady Reynolds-Averaged Navier-Stokes simulation has been carried out on impinging jets with different nozzle stand-off distances. A strong dependency of the jet characteristics on the nozzle height-to-diameter ratio was observed. The simulations show that an increase in this ratio results in larger shear stress and more distributed pressure on the wall. In the second step, an unsteady simulation using Large Eddy Simulation has been performed on an impinging jet with large stand-off distance. Good agreement was observed between the mean value results obtained from the current simulations and experiments. Unlike impinging jets with small stand-off distance, where the ring-like vortices keep their interconnected shape upon reaching the plate, no sign of interconnection was observed on the plate for the large stand-off distance case. A large deflection of the jet stagnation streamline was observed in comparison to the cases with small nozzle height-to-diameter ratios. Large fluctuations of the unsteady wall shear stresses were also captured. A boiling model was developed for impinging jets with heat transfer. An Eulerian-Eulerian two-phase flow model was implemented using an open source code for the simulation (OpenFOAM). Initially, an adiabatic two-phase model was developed for flow in a pipe. Following this, the energy equation was activated to account for non-adiabatic and boiling conditions. The simulation predictions were found to be in reasonable agreement with the experimental data and show significant improvement over previous numerical results. Finally, the model was upgraded for an impinging jet flow by implementing new correlations. The results obtained from the current model show reasonable agreement with the experimental results. The model can be confidently used for the evaluation of adiabatic and non-adiabatic impinging jet flows. Advisors/Committee Members: Ronald M Barron, Ramaswami Balachandar.

Subjects/Keywords: computational fluid dynamics; fluid mechanics; impinging jet; turbulence modelling; Mechanical Engineering

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APA (6^th Edition):

Shademan, M. (2015). CFD Simulation of Impinging Jet Flows and Boiling Heat Transfer. (Doctoral Dissertation). University of Windsor. Retrieved from http://scholar.uwindsor.ca/etd/5700

Chicago Manual of Style (16^th Edition):

Shademan, Mehrdad. “CFD Simulation of Impinging Jet Flows and Boiling Heat Transfer.” 2015. Doctoral Dissertation, University of Windsor. Accessed April 15, 2021. http://scholar.uwindsor.ca/etd/5700.

MLA Handbook (7^th Edition):

Shademan, Mehrdad. “CFD Simulation of Impinging Jet Flows and Boiling Heat Transfer.” 2015. Web. 15 Apr 2021.

Vancouver:

Shademan M. CFD Simulation of Impinging Jet Flows and Boiling Heat Transfer. [Internet] [Doctoral dissertation]. University of Windsor; 2015. [cited 2021 Apr 15]. Available from: http://scholar.uwindsor.ca/etd/5700.

Council of Science Editors:

Shademan M. CFD Simulation of Impinging Jet Flows and Boiling Heat Transfer. [Doctoral Dissertation]. University of Windsor; 2015. Available from: http://scholar.uwindsor.ca/etd/5700

University of Manchester

30. Wilson, Dean Robert. Computational Modelling of Turbulent Magnetohydrodynamic Flows.

Degree: 2016, University of Manchester

URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:303556

► The study of magnetohydrodynamics unifies the fields of fluid mechanics and electrodynamics to describe the interactions between magnetic fields and electrically conducting fluids. Flows described… (more)

▼ The study of magnetohydrodynamics unifies the fields of fluid mechanics and electrodynamics to describe the interactions between magnetic fields and electrically conducting fluids. Flows described by magnetohydrodynamics form a significant aspect in a wide range of engineering applications, from the liquid metal blankets designed to surround and remove heat from nuclear fusion reactors, to the delivery and guidance of nanoparticles in magnetic targeted drug delivery. The ability to optimize these, and other, processes is increasingly reliant on the accuracy and stability of the numerical models used to predict such flows. This thesis addresses this by providing a detailed assessment on the performance of two electromagnetically extended Reynolds-averaged Navier-Stokes models through computations of a number of electromagnetically influenced simple channel and Rayleigh-Bènard convective flows. The models tested were the low-Re k-ε linear eddy-viscosity model of Launder and Sharma (1974), with electromagnetic modifications as proposed by Kenjereš and Hanjalić (2000), and the low-Re stress-transport model of Hanjalić and Jakirlić (1993), with electromagnetic modifications as proposed by Kenjereš and Hanjalić (2004). First, a one-dimensional fully-developed turbulent channel flow was considered over a range of Reynolds and Hartmann numbers with a magnetic field applied in both wall-normal and streamwise directions. Results showed that contributions from the electromagnetic modifications were modest and, whilst both models inherently captured some of the reduction in mean strain that a wall-normal field imposed, results from the stress-transport model were consistently superior for both magnetic field directions. Then, three-dimensional time-dependent Rayleigh-Bènard convection was considered for two different Prandtl numbers, two different magnetic field directions and over a range of Hartmann numbers. Results revealed that, at sufficiently high magnetic field strengths, a dramatic reorganization of the flow structure is predicted to occur. The vertical magnetic field led to a larger number of thinner, more cylindrical plumes whilst the horizontal magnetic field caused a striking realignment of the roll cells' axes with the magnetic field lines. This was in agreement with both existing numerical simulations and physical intuition.The superior performance of the modified stress-transport model in both flows was attributed to both its ability to provide better representation of stress generation and other processes, and its ability to accommodate the electromagnetic modifications in a more natural, and exact, fashion. The results demonstrate the capabilities of the stress-transport approach in modelling MHD flows that are relevant to industry and offer potential for those wishing to control flow structure or levels of turbulence without recourse to mechanical means. Advisors/Committee Members: IACOVIDES, HECTOR H, Iacovides, Hector, Craft, Timothy.

Subjects/Keywords: Magnetohydrodynamics; Computational Fluid Dynamics; turbulence modelling; RANS; Buoyancy

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wilson, D. R. (2016). Computational Modelling of Turbulent Magnetohydrodynamic Flows. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:303556

Chicago Manual of Style (16^th Edition):

Wilson, Dean Robert. “Computational Modelling of Turbulent Magnetohydrodynamic Flows.” 2016. Doctoral Dissertation, University of Manchester. Accessed April 15, 2021. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:303556.

MLA Handbook (7^th Edition):

Wilson, Dean Robert. “Computational Modelling of Turbulent Magnetohydrodynamic Flows.” 2016. Web. 15 Apr 2021.

Vancouver:

Wilson DR. Computational Modelling of Turbulent Magnetohydrodynamic Flows. [Internet] [Doctoral dissertation]. University of Manchester; 2016. [cited 2021 Apr 15]. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:303556.

Council of Science Editors:

Wilson DR. Computational Modelling of Turbulent Magnetohydrodynamic Flows. [Doctoral Dissertation]. University of Manchester; 2016. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:303556

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