Advanced search options

Advanced Search Options 🞨

Browse by author name (“Author name starts with…”).

Find ETDs with:

in
/  
in
/  
in
/  
in

Written in Published in Earliest date Latest date

Sorted by

Results per page:

You searched for subject:(complex partial seizure). One record found.

Search Limiters

Last 2 Years | English Only

No search limiters apply to these results.

▼ Search Limiters


University of Toronto

1. Zhong, Muyuan. The Anticonvulsant Effects of Progesterone, its Metabolites, and 5α-Dihydroprogesterone Novel Analogs in Amygdala-kindled Seizures in Rats.

Degree: 2015, University of Toronto

Introduction: Complex partial epilepsy is the most common type of drug-resistant epilepsy in adults. The present study was designed to test the anticonvulsant activity of 5α-dihydroprogesterone (5α-DHP) novel analogs in an animal model of human complex partial epilepsy − the rat amygdala-kindling model. Methods: Confirmatory replication studies were carried out on progesterone and its metabolites. Subsequently, nine 5α-DHP novel analogs were screened for anticonvulsant potential. Finally, emerging lead compounds, MC008 and MC009, were examined in dose-response studies, time-response studies, and Lӧscher's ataxia toxicity studies. Results: Progesterone and its metabolites were generally anticonvulsant. Analogs MC008 and MC009 were effective against both the focal and the generalized kindled seizures. Toxic side-effects (ataxia), however, accompanied focal seizure suppression. Conclusion: MC008 and MC009 do not seem to be ideal candidates for the treating human complex partial seizures due to potential toxicity. Other 5α-DHP analogs have been synthesized and will be tested in future experiments.

M.Sc.

Advisors/Committee Members: Burnham, McIntyre W., Pharmacology.

Subjects/Keywords: 5α- DHP novel analogs; 5α-dihydroprogesterone; complex partial seizure; dose-response study; progesterone; rat-amygdala kindling; 0419

Record DetailsSimilar RecordsGoogle PlusoneFacebookTwitterCiteULikeMendeleyreddit

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Zhong, M. (2015). The Anticonvulsant Effects of Progesterone, its Metabolites, and 5α-Dihydroprogesterone Novel Analogs in Amygdala-kindled Seizures in Rats. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/70777

Chicago Manual of Style (16th Edition):

Zhong, Muyuan. “The Anticonvulsant Effects of Progesterone, its Metabolites, and 5α-Dihydroprogesterone Novel Analogs in Amygdala-kindled Seizures in Rats.” 2015. Masters Thesis, University of Toronto. Accessed November 22, 2017. http://hdl.handle.net/1807/70777.

MLA Handbook (7th Edition):

Zhong, Muyuan. “The Anticonvulsant Effects of Progesterone, its Metabolites, and 5α-Dihydroprogesterone Novel Analogs in Amygdala-kindled Seizures in Rats.” 2015. Web. 22 Nov 2017.

Vancouver:

Zhong M. The Anticonvulsant Effects of Progesterone, its Metabolites, and 5α-Dihydroprogesterone Novel Analogs in Amygdala-kindled Seizures in Rats. [Internet] [Masters thesis]. University of Toronto; 2015. [cited 2017 Nov 22]. Available from: http://hdl.handle.net/1807/70777.

Council of Science Editors:

Zhong M. The Anticonvulsant Effects of Progesterone, its Metabolites, and 5α-Dihydroprogesterone Novel Analogs in Amygdala-kindled Seizures in Rats. [Masters Thesis]. University of Toronto; 2015. Available from: http://hdl.handle.net/1807/70777

.