Penn State University
Kirimanjeswara, Girish Soorappa.
Antibody-mediated Clearance of Bordetella Species.
Degree: PhD, Pathobiology, 2004, Penn State University
This doctoral dissertation work focused on examining
the contribution of mucosal and serum antibodies to sterilizing
immunity against the respiratory pathogens, B. bronchiseptica and
B. pertussis. During the course of the investigation, we discovered
that the mechanism of antibody-mediated clearance of these closely
related subspecies of Bordetella differ significantly. Adoptively
transferred serum antibodies cleared the animal pathogen B.
bronchiseptica within three days of infection. Antibodies, however,
had a minimal effect on human adapted B. pertussis until after the
generation of a Th1 response. Comparative immunobiology of these
two subspecies in a mouse model revealed that B. pertussis is
initially able to resist antibody-mediated clearance via the
expression of pertussis toxin, which modulates the critical immune
responses required for this rapid bacterial elimination. This
suggests a model in which B. pertussis is able to transiently
infect immune individuals and persist in vaccinated populations.
This model is supported by epidemiological data indicating frequent
epidemics of whooping coughs in highly vaccinated populations.
Additionally, this study revealed distinct yet overlapping immune
surveillance mechanisms in different areas of the respiratory
tract. Together, this study provides important insights into the
evolution, adaptation, and epidemiology of B. pertussis. It also
aids in developing novel prophylactic and therapeutic strategies
for whooping cough. Above all, it makes substantial contributions
to the respiratory immunology.
Subjects/Keywords: complemenet; pertussis; passive transfer; antibodies;
bordetella; Fc receptors; TLRs
to Zotero / EndNote / Reference
APA (6th Edition):
Kirimanjeswara, G. S. (2004). Antibody-mediated Clearance of Bordetella Species. (Doctoral Dissertation). Penn State University. Retrieved from https://etda.libraries.psu.edu/catalog/6496
Chicago Manual of Style (16th Edition):
Kirimanjeswara, Girish Soorappa. “Antibody-mediated Clearance of Bordetella Species.” 2004. Doctoral Dissertation, Penn State University. Accessed September 16, 2019.
MLA Handbook (7th Edition):
Kirimanjeswara, Girish Soorappa. “Antibody-mediated Clearance of Bordetella Species.” 2004. Web. 16 Sep 2019.
Kirimanjeswara GS. Antibody-mediated Clearance of Bordetella Species. [Internet] [Doctoral dissertation]. Penn State University; 2004. [cited 2019 Sep 16].
Available from: https://etda.libraries.psu.edu/catalog/6496.
Council of Science Editors:
Kirimanjeswara GS. Antibody-mediated Clearance of Bordetella Species. [Doctoral Dissertation]. Penn State University; 2004. Available from: https://etda.libraries.psu.edu/catalog/6496