subject:(comparative effectiveness)

University of Melbourne

1. Steinfort, Daniel Paul. Endobronchial ultrasound in the management of lung cancer: integration of a new technology into clinical care.

Degree: 2012, University of Melbourne

URL: http://hdl.handle.net/11343/37699

► Previous studies have described technical aspects of endobronchial ultrasound (both radial & linear). These included performance of the techniques and diagnostic accuracy, though notably early… (more)

▼ Previous studies have described technical aspects of endobronchial ultrasound (both radial & linear). These included performance of the techniques and diagnostic accuracy, though notably early experience was confined to several centres with extensive & experienced interventional bronchoscopy services. Integration of new technology can evolve rapidly, preceding a more complete understanding of potential limitations and complications. The body of work presented in this thesis was commenced at a time where endobronchial ultrasound was being used more frequently in an increasing number of centres worldwide. There remained a number of outstanding questions regarding the optimal performance of the techniques and their safety profile. This thesis attempts to address several such issues to more clearly define how endobronchial ultrasound (EBUS) is best performed and best incorporated into routine clinical care. Radial EBUS has been demonstrated to have utility in assessment of peripheral lung lesions, though no comparison with alternate diagnostic procedures had previously been undertaken. I performed a prospective randomized pragmatic trial to determine the comparative effectiveness of endobronchial ultrasound-guided transbronchial lung biopsy (EBUS-TBLB) and CT-guided percutaneous needle biopsy (CT-PNB) for the investigation of PPL. Overall complication rates were higher in those undergoing CT-PNB (27% v 3%, p=0.03), while diagnostic accuracy of EBUS-TBLB was shown to be non-inferior to that of CT-PNB. Expected diagnostic accuracy and complication rates are likely to differ for individual patients on the basis of specific complex clinicoradiologic factors, which will influence the comparative effectiveness and cost-utility between EBUS-TBLB and CT-PNB for individual patients. Decision tree analysis is suited to applying clinical research findings to broader patient populations however more accurate understanding of diagnostic performance of EBUS-TBLB was required. A systematic review of published literature evaluating radial probe EBUS accuracy was performed to determine point sensitivity and specificity, and to construct a summary receiver-operating characteristic curve. Sub-group analysis and linear regression was used to identify possible sources of study heterogeneity. Meta-analysis demonstrated that EBUS is a safe and relatively accurate (point sensitivity of 0.73, 95%CI 0.70–0.76) tool in investigation of PPLs. Diagnostic sensitivity of EBUS-TBLB may be influenced by the prevalence of malignancy in the patient cohort being examined and lesion size. Decision-tree analysis was applied to compare downstream costs of endobronchial ultrasound-guided transbronchial lung biopsy (EBUS-TBLB) with CT-guided percutaneous needle biopsy (CT-PNB). The costs of EBUS-TBLB and CT-PNB to evaluate PPL appear to be equivalent. Specific factors known to influence procedural outcomes will influence…

Subjects/Keywords: endobronchial ultrasound; comparative effectiveness research; cost effectiveness

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Steinfort, D. P. (2012). Endobronchial ultrasound in the management of lung cancer: integration of a new technology into clinical care. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/37699

Chicago Manual of Style (16^th Edition):

Steinfort, Daniel Paul. “Endobronchial ultrasound in the management of lung cancer: integration of a new technology into clinical care.” 2012. Doctoral Dissertation, University of Melbourne. Accessed February 25, 2021. http://hdl.handle.net/11343/37699.

MLA Handbook (7^th Edition):

Steinfort, Daniel Paul. “Endobronchial ultrasound in the management of lung cancer: integration of a new technology into clinical care.” 2012. Web. 25 Feb 2021.

Vancouver:

Steinfort DP. Endobronchial ultrasound in the management of lung cancer: integration of a new technology into clinical care. [Internet] [Doctoral dissertation]. University of Melbourne; 2012. [cited 2021 Feb 25]. Available from: http://hdl.handle.net/11343/37699.

Council of Science Editors:

Steinfort DP. Endobronchial ultrasound in the management of lung cancer: integration of a new technology into clinical care. [Doctoral Dissertation]. University of Melbourne; 2012. Available from: http://hdl.handle.net/11343/37699

Nelson Mandela Metropolitan University

2. Hattingh, Christiaan Arnoldus. High-performance organisational assessment : a South African case study.

Degree: Faculty of Business and Economic Sciences, 2013, Nelson Mandela Metropolitan University

URL: http://hdl.handle.net/10948/d1020249

► A fundamental shift occurred in the global economy during the last three decades and even more so in the period since the 2008 financial crises.… (more)

▼ A fundamental shift occurred in the global economy during the last three decades and even more so in the period since the 2008 financial crises. As a result of the advancing technology, national economies no longer self-contained entities protected from international competition by geographical distances, times zones, languages barriers, government regulations and culture or business systems. The effect of globalisation has further manifested in the global economic slow-down since 2008, where spending is constrained and consumers have become more discerning in their value considerations. The dual challenge of globalisation of competition and global economic slow-down is increasingly forcing businesses to do some introspection not only in terms of their cost structures, but also in terms of their value propositions in search of sustainable organisational success. Given the limited influence that businesses have over its external environment, an internal perspective is proposed where this problem is approached by means of a high-performance evaluation case study. The aim is to identify constraints that have resulted from more recent responses to market challenges and to establish which interventions to elevate in order to alleviate such constraints. It is proposed that if management and organisational practices that organisations employ in their daily functions affect the discretionary effort that employees contribute, then organisations should be able to gain insight into variations in organisational performance through evaluating and understanding these practices. This treatise focusses on organisational characteristics that drive high performance and propose interventions to enhance the environment for the development of a high performance culture within a single organisation. The research topic fell within the quantitative paradigm with data being collected through the use of a questionnaire. The results were analysed and interpreted to ascertain how current practice aligns with the theory. Recommendations are submitted within the context of the prevailing literature on the subject of high performance organisations and the related high performance characteristics of the organisation as based on the empirical data.

Subjects/Keywords: Organizational effectiveness – South Africa – Measurement; Comparative organization

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hattingh, C. A. (2013). High-performance organisational assessment : a South African case study. (Thesis). Nelson Mandela Metropolitan University. Retrieved from http://hdl.handle.net/10948/d1020249

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hattingh, Christiaan Arnoldus. “High-performance organisational assessment : a South African case study.” 2013. Thesis, Nelson Mandela Metropolitan University. Accessed February 25, 2021. http://hdl.handle.net/10948/d1020249.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hattingh, Christiaan Arnoldus. “High-performance organisational assessment : a South African case study.” 2013. Web. 25 Feb 2021.

Vancouver:

Hattingh CA. High-performance organisational assessment : a South African case study. [Internet] [Thesis]. Nelson Mandela Metropolitan University; 2013. [cited 2021 Feb 25]. Available from: http://hdl.handle.net/10948/d1020249.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hattingh CA. High-performance organisational assessment : a South African case study. [Thesis]. Nelson Mandela Metropolitan University; 2013. Available from: http://hdl.handle.net/10948/d1020249

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Minnesota

3. Popp, Jonah. A modeling-based evaluation of the evidential basis for and cost effectiveness of intensive post-diagnosis extra-colonic surveillance of non-metastatic colorectal cancer patients.

Degree: PhD, Health Services Research, Policy and Administration, 2018, University of Minnesota

URL: http://hdl.handle.net/11299/196531

► Between 70-80% of colorectal cancer (CRC) patients present with non-metastatic disease and can potentially be cured with surgical resection. However, between 5-60% of these patients… (more)

▼ Between 70-80% of colorectal cancer (CRC) patients present with non-metastatic disease and can potentially be cured with surgical resection. However, between 5-60% of these patients will suffer a recurrence, generally in the form of late-occurring metastatic disease. For this reason, most professional-society guidelines recommend intensive extra-colonic-focused surveillance (CT scans and routine testing for tumor-markers) of these patients for 3-5 years post-diagnosis with the aim of detecting recurrence at an earlier stage when it is more likely to be amenable to salvage surgery with a curative intent. Until recently, this practice was corroborated by the results of meta-analyses of randomized control trials (RCTs) comparing more intensive with less intensive (or no) surveillance. However, the negative results of two large recently-published RCTs – the UK FACS trial and the Italian GILDA trial - and of subsequently updated meta-analyses have cast doubt on the value of aggressive follow-up and ultimately the value of aggressive treatment of recurrent CRC. In this dissertation I use a modeling analysis to argue that the results of these two trials have been misinterpreted. Accordingly, the conclusions of the most recent meta-analyses are misguided and calls to throw in the towel on intensive follow-up are premature. The negative trial results are not surprising given the low recurrence rates of contemporary practice and thus the small proportion of patients who could potentially benefit from aggressive follow-up. I show that, if aggressive follow-up were to confer a survival advantage in virtue of increasing the chances of salvage therapy with a curative intent, the average benefit would be very small. Moreover, the two trials would have had essentially no chance to detect an effect of that size, and this problem of insufficient power was likely exacerbated in at least one of the trials by a sizable chance recurrence imbalance. I further show that it is unlikely that a RCT with adequate power could ever or will ever be possible. However, I argue there is reason to take seriously the hypothesis that aggressive use of follow-up testing and subsequent salvage therapy can offer a small survival advantage on average. Finally, I report the results of a modeling-based cost-effectiveness analysis to identify follow-up strategies that would be cost-effective if this hypothesis is correct.

Subjects/Keywords: colorectal cancer; comparative effectiveness; cost effectiveness; health economics

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Popp, J. (2018). A modeling-based evaluation of the evidential basis for and cost effectiveness of intensive post-diagnosis extra-colonic surveillance of non-metastatic colorectal cancer patients. (Doctoral Dissertation). University of Minnesota. Retrieved from http://hdl.handle.net/11299/196531

Chicago Manual of Style (16^th Edition):

Popp, Jonah. “A modeling-based evaluation of the evidential basis for and cost effectiveness of intensive post-diagnosis extra-colonic surveillance of non-metastatic colorectal cancer patients.” 2018. Doctoral Dissertation, University of Minnesota. Accessed February 25, 2021. http://hdl.handle.net/11299/196531.

MLA Handbook (7^th Edition):

Popp, Jonah. “A modeling-based evaluation of the evidential basis for and cost effectiveness of intensive post-diagnosis extra-colonic surveillance of non-metastatic colorectal cancer patients.” 2018. Web. 25 Feb 2021.

Vancouver:

Popp J. A modeling-based evaluation of the evidential basis for and cost effectiveness of intensive post-diagnosis extra-colonic surveillance of non-metastatic colorectal cancer patients. [Internet] [Doctoral dissertation]. University of Minnesota; 2018. [cited 2021 Feb 25]. Available from: http://hdl.handle.net/11299/196531.

Council of Science Editors:

Popp J. A modeling-based evaluation of the evidential basis for and cost effectiveness of intensive post-diagnosis extra-colonic surveillance of non-metastatic colorectal cancer patients. [Doctoral Dissertation]. University of Minnesota; 2018. Available from: http://hdl.handle.net/11299/196531

University of Georgia

4. Patel, Palak Krunal Kumar. Burden of prostate cancer.

Degree: 2015, University of Georgia

URL: http://hdl.handle.net/10724/31266

► Objective: Increased detection of clinically insignificant prostate cancer with routinely used diagnostic tests, as well as uncertainties in the available treatments to manage the low… (more)

▼ Objective: Increased detection of clinically insignificant prostate cancer with routinely used diagnostic tests, as well as uncertainties in the available treatments to manage the low risk disease, are expected to increase the future burden of the prostate cancer substantially. This study aims to address three major areas in the field of prostate cancer including economic burden, diagnostics, and treatment for low risk disease. Methods: The economic burden of prostate cancer was assessed retrospectively using a population based database. A novel imaging technique such as multiparametric magnetic resonance imaging (MP-MRI) assisted transrectal ultrasound (TRUS) guided biopsy in prostate cancer diagnosis was assessed and compared with the conventional 12-core TRUS guided biopsy by performing a cost-effectiveness analysis. The Surveillance Epidemiology and End Results-Medicare database was used to compare toxicity profiles among localized prostate cancer patients who receive either conservative management or immediate treatment. Results: An annual average total of $5.6 billion was spent on prostate cancer related conditions in 2010 in the United States. Use of chemotherapy and ultrasound increased the expenditure related to outpatient visits significantly; whereas use of ultrasound and x-ray increased office-based visit costs significantly. The MP-MRI strategy was found to be cost-effective compared to conventional TRUS guided biopsy assuming a threshold to pay for is $1781.60. Conservative management was found to have lower odds of urinary, rectal, and erectile complications without compromising the survival within a 5 year time period than the immediate treatment. Conclusion: Routinely used TRUS guided biopsy is associated with a higher economic burden on society. There is a need for tests that can diagnose prostate cancer accurately. MP-MRI/TRUS fusion guided biopsy can characterize prostate cancer accurately and was found to be cost-effective compared to TRUS guided biopsy provided the threshold to pay for this technology is at least $1781.60. To avoid overtreatment among low risk prostate cancer patients, a conservative management approach was found to be a better option because patients can delay or avoid treatment related side effects without compromising prostate cancer specific survival within a 5 year time period.

Subjects/Keywords: Prostate cancer; economic burden; cost-effectiveness; multiparametric magnetic resonance imaging; conservative management; comparative effectiveness analysis

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Patel, P. K. K. (2015). Burden of prostate cancer. (Thesis). University of Georgia. Retrieved from http://hdl.handle.net/10724/31266

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Patel, Palak Krunal Kumar. “Burden of prostate cancer.” 2015. Thesis, University of Georgia. Accessed February 25, 2021. http://hdl.handle.net/10724/31266.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Patel, Palak Krunal Kumar. “Burden of prostate cancer.” 2015. Web. 25 Feb 2021.

Vancouver:

Patel PKK. Burden of prostate cancer. [Internet] [Thesis]. University of Georgia; 2015. [cited 2021 Feb 25]. Available from: http://hdl.handle.net/10724/31266.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Patel PKK. Burden of prostate cancer. [Thesis]. University of Georgia; 2015. Available from: http://hdl.handle.net/10724/31266

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Minnesota

5. Jalal, Hawre. Long-term Comparative Effectiveness of Rheumatoid Arthritis Treatment Strategies.

Degree: PhD, Health Services Research, Policy and Administration, 2013, University of Minnesota

URL: http://hdl.handle.net/11299/174858

► Rheumatoid arthritis (RA) is a chronic debilitating disease characterized by progressive joint damage, reduced quality of life, loss of productivity and premature death. It affects… (more)

▼ Rheumatoid arthritis (RA) is a chronic debilitating disease characterized by progressive joint damage, reduced quality of life, loss of productivity and premature death. It affects 1% of the adult US population, and is one of the most demanding diseases on our healthcare resources. Biologic disease modifiers are new drugs that provide hope to improve the course of RA; however, biologics are among the most expensive specialty drugs. Although the treatment costs of RA have recently increased with the introduction of biologics, most of the economic and societal impacts are due to consequences of RA rather than direct treatment costs. Thus, the cost-effectiveness of biologics in RA is of high priority as recognized by many agencies including the National Institute of Health. This thesis focuses on three limitations of the current cost-effectiveness analyses (CEA) of biologics in RA. First, Most CEAs are based on randomized clinical trials (RCT) that are rarely applicable to real-life clinical practice. This thesis examines the long-term comparative clinical- and cost-effectiveness of biologics using clinical practice data from a large registry of RA patients (The National Data-Bank of Rheumatic Diseases). Second, we lack a meta-analytical approach specific to CEAs, and previous tools are deemed inappropriate. This thesis presents a novel approach of meta-analysis specific to CEAs. Using this tool we examine if prior CEAs of biologics in RA are consistent. Third, due to the biologics' high costs, RA treatment guidelines often recommend biologics as second line agents after nonbiologics. However, early aggressive treatment is crucial to avoid permanent joint damage. In this thesis we use Markov decision processes (MDP) as an innovative approach to identify the optimal timing of biologics in RA. The results from this analysis have significant policy, clinical and methodological implications. This work provides important insights into the comparative effectiveness of biologics in RA from a US societal perspective, which can influence health policy and medical insurance coverage decisions. Methodologically, the proposed meta-analytical approach can be applied to other conditions, and have the potential to reconcile the inconsistencies in published CEAs and improve the quality of future studies.

Subjects/Keywords: comparative effectiveness; Cost-effectiveness analysis; Markov Decision Processes; Meta-analysis; Rheumatoid Arthritis

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Jalal, H. (2013). Long-term Comparative Effectiveness of Rheumatoid Arthritis Treatment Strategies. (Doctoral Dissertation). University of Minnesota. Retrieved from http://hdl.handle.net/11299/174858

Chicago Manual of Style (16^th Edition):

Jalal, Hawre. “Long-term Comparative Effectiveness of Rheumatoid Arthritis Treatment Strategies.” 2013. Doctoral Dissertation, University of Minnesota. Accessed February 25, 2021. http://hdl.handle.net/11299/174858.

MLA Handbook (7^th Edition):

Jalal, Hawre. “Long-term Comparative Effectiveness of Rheumatoid Arthritis Treatment Strategies.” 2013. Web. 25 Feb 2021.

Vancouver:

Jalal H. Long-term Comparative Effectiveness of Rheumatoid Arthritis Treatment Strategies. [Internet] [Doctoral dissertation]. University of Minnesota; 2013. [cited 2021 Feb 25]. Available from: http://hdl.handle.net/11299/174858.

Council of Science Editors:

Jalal H. Long-term Comparative Effectiveness of Rheumatoid Arthritis Treatment Strategies. [Doctoral Dissertation]. University of Minnesota; 2013. Available from: http://hdl.handle.net/11299/174858

Boston University

6. Powell, Ryan. A novel approach to support evidence-based medicine: should sulfonylureas remain an acceptable therapy for diabetes?.

Degree: PhD, Health Services Research, 2017, Boston University

URL: http://hdl.handle.net/2144/23373

► A key element in evidence-based medicine approaches is the ability for clinicians to evaluate the scientific rigor and relevance of research evidence. In the treatment… (more)

▼ A key element in evidence-based medicine approaches is the ability for clinicians to evaluate the scientific rigor and relevance of research evidence. In the treatment of diabetes, clinicians make increasingly difficult decisions about which drug regimens are best for their patients with limited evidence-based information. While the consensus is that metformin should be the initial drug treatment when diet and exercise are not sufficient, clinicians disagree on whether sulfonylureas should remain a suitable therapy after metformin. While this would be improved with further research investigating the comparative safety of therapeutic options, there is also need for better ways to synthesize available information to guide evidence-based decision-making in health services research. Study 1 summarizes the pre-existing evidence on the long-term safety risks associated with sulfonylurea therapy relative to other drug classes. Results from a series of meta-analyses provide some evidence that sulfonylureas are associated with elevated all-cause mortality and cardiovascular risks relative to several other medications, either as a monotherapy or in combination with metformin. Study 2 analyzes the comparative safety of second-line treatment in diabetic patients in the Veterans Health Administration to address gaps in the literature. Results suggest that second-line use of sulfonylureas is associated with increased risks compared to thiazolidinediones. Results also suggest that changes to existing metformin therapy may lead to differential hazards. Clinicians may disagree about the quality of the evidence as well as the relevancy to their own treatment population. Improvements in methods for evidence-based medicine that take this into account are needed. Study 3 applies an underutilized research method that allows for a more thoughtful synthesis of all available evidence. This framework allows clinicians to incorporate the scientific rigor and relevancy of previous study results when integrating new data into their current knowledge base. Results suggest an elevated risk in all models for sulfonylureas compared to thiazolidinediones and highlight the need to design more focused research to support clinical decision-making around medication safety. This novel application to evidence synthesis shows promise as applied to a health services research problem and has potential as a useful framework in other health services research areas.

Subjects/Keywords: Public health; Bayesian; TZD; Comparative effectiveness; Comparative study; Meta-analysis; Research design

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Powell, R. (2017). A novel approach to support evidence-based medicine: should sulfonylureas remain an acceptable therapy for diabetes?. (Doctoral Dissertation). Boston University. Retrieved from http://hdl.handle.net/2144/23373

Chicago Manual of Style (16^th Edition):

Powell, Ryan. “A novel approach to support evidence-based medicine: should sulfonylureas remain an acceptable therapy for diabetes?.” 2017. Doctoral Dissertation, Boston University. Accessed February 25, 2021. http://hdl.handle.net/2144/23373.

MLA Handbook (7^th Edition):

Powell, Ryan. “A novel approach to support evidence-based medicine: should sulfonylureas remain an acceptable therapy for diabetes?.” 2017. Web. 25 Feb 2021.

Vancouver:

Powell R. A novel approach to support evidence-based medicine: should sulfonylureas remain an acceptable therapy for diabetes?. [Internet] [Doctoral dissertation]. Boston University; 2017. [cited 2021 Feb 25]. Available from: http://hdl.handle.net/2144/23373.

Council of Science Editors:

Powell R. A novel approach to support evidence-based medicine: should sulfonylureas remain an acceptable therapy for diabetes?. [Doctoral Dissertation]. Boston University; 2017. Available from: http://hdl.handle.net/2144/23373

NSYSU

7. Cheng, Hung-Jui. Know the enemy and know yourself: The Influence of comparison target and message framing in comparative advertising.

Degree: Master, Institute of Marketing Communication, 2015, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0414115-111554

► New brands often wish to achieve quick brand exposure and provide consumers detailed product information through comparative advertising. Due to the strict regulations of the… (more)

▼ New brands often wish to achieve quick brand exposure and provide consumers detailed product information through comparative advertising. Due to the strict regulations of the fair trade laws in Taiwan, when advertisers adopt comparative advertising, they sometimes avoid comparing relative strengths and weaknesses with the rival products in a direct way of confrontation; instead, a fair and objective market average value will be used as a comparison object. In the first part of this study, it explores when the objective market average value has been adopted as a comparison object, or showed in the advertisements with rival products simultaneously, whether it can effectively enhance the objectivity and credibility of the information, value of reference, and advertising effectiveness. This study also discusses the moderating effects of individual regulatory focus. In addition, when considering the increase of comparison objects, the number of comparison objects and the gap between different objects may affect the reference value of comparison objects based on anchoring theory. Therefore, the study also discusses the impact of the number of comparison objects and the gap between objectsâ performances on advertising effectiveness. In addition to the comparisons with numbers, texts are also a common way used to compare the pros and cons between different products in practices. Rephrasing the texts often result in the effectiveness of message framing. In the second part of this study, the focal products and rival products will be represented with the message frames of gains and losses respectively. This study explores the fit effects between message frames and individual regulatory focus. Additionally, the advertising effectiveness of the comparability between two message frames is examined. Two experiments are conducted to test the hypotheses. Experiment 1 reveals that that the addition of a market average value as a comparison object can enhance advertising effectiveness. Multiple comparison objects (multiple anchors) can lead to better advertising effectiveness than single comparison object (single anchor). Similar performances of comparison objects (high anchor-consistency) can also lead to better advertising effectiveness than dissimilar ones (low anchor-consistency). Consumers with promotion focus are concerned more about if the advertised focal product defeats the rival product. However, consumers with prevention focus are concerned more about if the performances of the advertised product are better than the average market values. Therefore, consumers with promotion focus (prevention focus) respond better to the comparative ads that use the rival product (average market values) as the comparison object. Experiment 2 finds that when the message frames adopted by the two comparative products have high (vs. low) degree of comparability, it will lead to better advertising effectiveness. When the gain frames of the advertised product and the loss frames of the rival product achieve a fit with consumer individual… Advisors/Committee Members: Hsuan-Yi Chou (committee member), Hsin-Hsien Liu (chair), Shu-Fang Liu (chair).

Subjects/Keywords: Message Framing; Anchoring Theory; Regulatory Focus; Comparative Advertising; Advertising Effectiveness

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cheng, H. (2015). Know the enemy and know yourself: The Influence of comparison target and message framing in comparative advertising. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0414115-111554

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Cheng, Hung-Jui. “Know the enemy and know yourself: The Influence of comparison target and message framing in comparative advertising.” 2015. Thesis, NSYSU. Accessed February 25, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0414115-111554.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Cheng, Hung-Jui. “Know the enemy and know yourself: The Influence of comparison target and message framing in comparative advertising.” 2015. Web. 25 Feb 2021.

Vancouver:

Cheng H. Know the enemy and know yourself: The Influence of comparison target and message framing in comparative advertising. [Internet] [Thesis]. NSYSU; 2015. [cited 2021 Feb 25]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0414115-111554.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cheng H. Know the enemy and know yourself: The Influence of comparison target and message framing in comparative advertising. [Thesis]. NSYSU; 2015. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0414115-111554

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Alberta

8. El Shayeb, Mohamed. Reasons for not receiving standard of care treatment and effectiveness of capecitabine in stage III colon cancer patients in Alberta.

Degree: MS, School of Public Health Sciences, 2011, University of Alberta

URL: https://era.library.ualberta.ca/files/5x21tg66h

► Adjuvant chemotherapy is the standard of care for stage-III colon cancer. Despite this, large proportions of patients do not receive it; the oncologist may not… (more)

Subjects/Keywords: adjuvant chemotherapy; colon cancer; comparative effectiveness; standard of care

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

El Shayeb, M. (2011). Reasons for not receiving standard of care treatment and effectiveness of capecitabine in stage III colon cancer patients in Alberta. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/5x21tg66h

Chicago Manual of Style (16^th Edition):

El Shayeb, Mohamed. “Reasons for not receiving standard of care treatment and effectiveness of capecitabine in stage III colon cancer patients in Alberta.” 2011. Masters Thesis, University of Alberta. Accessed February 25, 2021. https://era.library.ualberta.ca/files/5x21tg66h.

MLA Handbook (7^th Edition):

El Shayeb, Mohamed. “Reasons for not receiving standard of care treatment and effectiveness of capecitabine in stage III colon cancer patients in Alberta.” 2011. Web. 25 Feb 2021.

Vancouver:

El Shayeb M. Reasons for not receiving standard of care treatment and effectiveness of capecitabine in stage III colon cancer patients in Alberta. [Internet] [Masters thesis]. University of Alberta; 2011. [cited 2021 Feb 25]. Available from: https://era.library.ualberta.ca/files/5x21tg66h.

Council of Science Editors:

El Shayeb M. Reasons for not receiving standard of care treatment and effectiveness of capecitabine in stage III colon cancer patients in Alberta. [Masters Thesis]. University of Alberta; 2011. Available from: https://era.library.ualberta.ca/files/5x21tg66h

Universiteit Utrecht

9. Broek, M. van den. Preventing money laundering: A legal study on the effectiveness of supervision in the European Union.

Degree: 2015, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/312416

► The process of concealing illegally obtained proceeds, better known as money laundering, is criminalised virtually all around the world and has been a law enforcement… (more)

▼ The process of concealing illegally obtained proceeds, better known as money laundering, is criminalised virtually all around the world and has been a law enforcement priority since the early 1990s. The international nature of money laundering, combined with estimations on the scope and the distorting effects it may bring about, make it a grave danger to national and international financial markets. At the same time money laundering is considered a danger to society due to its strong interaction with organised drugs and white-collar crime. Over the years a ‘twin-track approach’ has been developed aiming at the prevention of money laundering on the one hand, and punishing the money launderers on the other. Within the preventive anti-money laundering policy, supervision plays a key role. Although money laundering in general has attracted a great deal of attention from the academic world, supervision is an aspect that has remained underexposed in research. This research therefore focuses on the effectiveness of anti-money laundering supervision of banks, real estate agents and accountants in the European Union. Understanding that the EU Directive on the prevention of the use of the financial system for the purpose of money laundering and terrorist financing (‘Third Directive’) has left the design of supervision mostly to the EU Member States, their choices have been influenced by factors such as national politics, culture, the legal system, the economy and finances. As a result of these influences, a patchwork of anti-money laundering supervisory architectures exists in the European Union. This research identifies four supervisory models in the EU: the FIU model, the external model, the internal model and the hybrid model. The FIU model’s main characteristic is that the financial intelligence unit is the national authority with the final responsibility foranti-money laundering supervision. In the external model, supervision is formally exercised by public administrative or Government authorities that have no direct or professional relationship with the supervisees. The guiding principle of the internal model, is that where anti-money laundering supervision can be carried out by internal supervisors, these will be assigned with this task. The hybrid model combines, in different gradations, different elements of the aforementioned models. The models are the foundation for the country selection in this research. The countries that are further studied are the Netherlands, Spain, Sweden and the United Kingdom. They each represent one of the models identified. From the perspective of effective supervision this research thoroughly analyses the legislation, the institutional settings and competences of the anti-money laundering supervisors in the four selected countries, as well as the application of these competences in practice. Advisors/Committee Members: Addink, G.H., Unger, B., Duijkersloot, A.P.W..

Subjects/Keywords: supervision; money laundering; models; effectiveness; European Union; administrative law; comparative research

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Broek, M. v. d. (2015). Preventing money laundering: A legal study on the effectiveness of supervision in the European Union. (Doctoral Dissertation). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/312416

Chicago Manual of Style (16^th Edition):

Broek, M van den. “Preventing money laundering: A legal study on the effectiveness of supervision in the European Union.” 2015. Doctoral Dissertation, Universiteit Utrecht. Accessed February 25, 2021. http://dspace.library.uu.nl:8080/handle/1874/312416.

MLA Handbook (7^th Edition):

Broek, M van den. “Preventing money laundering: A legal study on the effectiveness of supervision in the European Union.” 2015. Web. 25 Feb 2021.

Vancouver:

Broek Mvd. Preventing money laundering: A legal study on the effectiveness of supervision in the European Union. [Internet] [Doctoral dissertation]. Universiteit Utrecht; 2015. [cited 2021 Feb 25]. Available from: http://dspace.library.uu.nl:8080/handle/1874/312416.

Council of Science Editors:

Broek Mvd. Preventing money laundering: A legal study on the effectiveness of supervision in the European Union. [Doctoral Dissertation]. Universiteit Utrecht; 2015. Available from: http://dspace.library.uu.nl:8080/handle/1874/312416

10. Whicher, Danielle Marie. Rethinking Informed Consent Requirements for Pragmatic Comparative Effectiveness Trials.

Degree: 2014, Johns Hopkins University

URL: http://jhir.library.jhu.edu/handle/1774.2/37916

► Recently, there has been an increasing demand for more and higher quality evidence of the comparative effectiveness of different health technologies. Much of the comparative… (more)

▼ Recently, there has been an increasing demand for more and higher quality evidence of the comparative effectiveness of different health technologies. Much of the comparative effectiveness research (CER) designed to address this demand will compare widely-used technologies and will be closely integrated with clinical care. These design features raise the question of whether current standards of informed consent should always be required for CER studies. Considering the acceptability of alternatives to informed consent is important as alternatives may improve the efficiency and quality of this research. This dissertation considers whether alternatives to informed consent are morally and socially acceptable by addressing three aims, each of which is explored in a separate paper. Aim one explores which alternatives to informed consent are acceptable to key stakeholders for low-risk CER trials of widely-used therapies. To address this aim, interviews were conducted with institutional review board members and researchers and focus groups were conducted with patients at two health systems. The results demonstrate that many participants felt that although it was important for eligible individuals to be informed about CER trials, it was acceptable to streamline the amount of information disclosed and to ask individuals to opt-out if they would prefer not to participate. Aim two considers which alternatives to prospective informed consent are morally permissible for CER studies. Addressing this aim, paper two is a moral analysis that argues that when enrolling individuals in these activities, it is sometimes acceptable to limit individual choice in situations where the decision to participate is unlikely to engage important self-determination interests that individuals have. Based on this argument, several recommendations regarding the moral permissibility of altering consent requirements for CER are provided. Aim three develops preliminary policy recommendations for reforming the informed consent regulations. Building on aims one and two, paper three suggests that it may be appropriate to streamline disclosure statements for low-risk CER trials and that it may also be appropriate to ask participants to opt-out instead of opt-in. However, in order for policy change to occur, it is necessary to continue to build the case for the importance of conducting CER studies. Advisors/Committee Members: Segal, Jodi (advisor).

Subjects/Keywords: bioethics; comparative effectiveness research; informed consent; stakeholder engagement

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Whicher, D. M. (2014). Rethinking Informed Consent Requirements for Pragmatic Comparative Effectiveness Trials. (Thesis). Johns Hopkins University. Retrieved from http://jhir.library.jhu.edu/handle/1774.2/37916

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Whicher, Danielle Marie. “Rethinking Informed Consent Requirements for Pragmatic Comparative Effectiveness Trials.” 2014. Thesis, Johns Hopkins University. Accessed February 25, 2021. http://jhir.library.jhu.edu/handle/1774.2/37916.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Whicher, Danielle Marie. “Rethinking Informed Consent Requirements for Pragmatic Comparative Effectiveness Trials.” 2014. Web. 25 Feb 2021.

Vancouver:

Whicher DM. Rethinking Informed Consent Requirements for Pragmatic Comparative Effectiveness Trials. [Internet] [Thesis]. Johns Hopkins University; 2014. [cited 2021 Feb 25]. Available from: http://jhir.library.jhu.edu/handle/1774.2/37916.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Whicher DM. Rethinking Informed Consent Requirements for Pragmatic Comparative Effectiveness Trials. [Thesis]. Johns Hopkins University; 2014. Available from: http://jhir.library.jhu.edu/handle/1774.2/37916

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas A&M University

11. Mardock, Michelle 1967-. Comparison of Two Diet and Exercise Approaches on Weight Loss and Health Outcomes in Women.

Degree: PhD, Kinesiology, 2012, Texas A&M University

URL: http://hdl.handle.net/1969.1/148237

► The purpose of this study was to determine the effects of following either the Curves® Fitness and Weight Management Plan or the Weight Watchers® Momentum™… (more)

▼ The purpose of this study was to determine the effects of following either the Curves® Fitness and Weight Management Plan or the Weight Watchers® Momentum™ Plan on body composition and markers of health and fitness in previously sedentary obese women. Fifty-one women (age 35±8 yrs; height 163±7 cm; weight 90±1 kg; BMI 34±5 kg/m2; 47±7% body fat) were randomized to participate in the Curves® (C) or Weight Watchers® (W) weight loss programs for 16-wks. Participants in the C group (n=24) followed a 1,200 kcal/d diet for 1-wk; 1,500 kcal/d diet for 3 wks (~30%:45% CHO:PRO); and 2,000 kcals/d for 2-wks (45:30) and repeated this diet while participating in a supervised Curves® with Zumba program 3-d-wk. Remaining subjects (n=27) followed the W point-based diet program, received weekly group counseling, and were encouraged to exercise. Body composition, anthropometrics, resting energy expenditure (REE), lipid biomarkers, and hormone concentrations were assessed at 0, 4, 10, and 16 weeks. Maximal cardiopulmonary exercise capacity and upper and lower body isotonic strength and endurance were assessed at 0 and 16 weeks. Data were analyzed using multivariate analysis of variance for repeated measures. MANOVA analysis of body composition data revealed overall time (Wilks’ Lamda p=0.001) and time by diet effects (Wilks’ Lamda p=0.003). Subjects in both groups lost a similar amount of total mass (C -2.4±2.0, -4.1±3.4, -5.1±3.9; W -2.3±2.3, -4.5±3.0, -5.5±4.6 kg, p=0.78). However, subjects in the C group tended to have a greater reduction in percent body fat (C -3.3±5.2, -3.2±4.6, -4.7±5.4; W 0.6±6.7, -0.6±8.3, -1.4±8.1%, p=0.10) and body fat mass (C -3.9±5.5, -4.6±5.3, -6.4±5.9; W -0.4±5.7, -2.1±6.7, -2.9±7.8 kg, p=0.09), while maintaining FFM (C 1.5±4.3, 0.52±3.7, 1.3±4.0; W -1.8±5.4, -2.4±5.8, -2.5±5.1, p=0.01). While both groups had increases cardiovascular fitness, the C group experienced improvements in upper body muscular endurance (C 1.4±3.9; W -1.2±2.4 repetitions, p=0.006). Both groups experienced improvements in lipid biomarkers; however, only the C group experienced a moderate increase in HDL-c. Results indicate that participants following the C program experienced more favorable changes in body composition and markers of fitness and health than participants in the W program. Advisors/Committee Members: Kreider, Richard B (advisor), Riechman, Steven E (committee member), Murano, Peter S (committee member), Lightfoot, J Timothy (committee member).

Subjects/Keywords: Comparative Effectiveness; Comparison; Supervised Exercise Program; Exercise; Weight Loss; Weight

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mardock, M. 1. (2012). Comparison of Two Diet and Exercise Approaches on Weight Loss and Health Outcomes in Women. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/148237

Chicago Manual of Style (16^th Edition):

Mardock, Michelle 1967-. “Comparison of Two Diet and Exercise Approaches on Weight Loss and Health Outcomes in Women.” 2012. Doctoral Dissertation, Texas A&M University. Accessed February 25, 2021. http://hdl.handle.net/1969.1/148237.

MLA Handbook (7^th Edition):

Mardock, Michelle 1967-. “Comparison of Two Diet and Exercise Approaches on Weight Loss and Health Outcomes in Women.” 2012. Web. 25 Feb 2021.

Vancouver:

Mardock M1. Comparison of Two Diet and Exercise Approaches on Weight Loss and Health Outcomes in Women. [Internet] [Doctoral dissertation]. Texas A&M University; 2012. [cited 2021 Feb 25]. Available from: http://hdl.handle.net/1969.1/148237.

Council of Science Editors:

Mardock M1. Comparison of Two Diet and Exercise Approaches on Weight Loss and Health Outcomes in Women. [Doctoral Dissertation]. Texas A&M University; 2012. Available from: http://hdl.handle.net/1969.1/148237

University of Pretoria

12. Maphosa, Jonathan M. A comparative study of effectiveness of green taxes in South Africa and developed countries.

Degree: Mercantile Law, 2014, University of Pretoria

URL: http://hdl.handle.net/2263/41314

► South Africa has been going through a series of political, economic and social changes since 1994. These changes have transformed it into a state that… (more)

▼ South Africa has been going through a series of political, economic and social changes since 1994. These changes have transformed it into a state that shows increased commitment to sustainable development. Although the country is considered as one of the largest developing country emitters of pollution, the South African government has recognised the need to move towards a low-carbon society. The country’s participation in international climate mitigation bodies has seen its commitment to reduce greenhouse gas (GHG) emissions of 34% by 2020 and 42% by 2025. South Africa has committed to achieve these goals provided that it receives the necessary finance, technology and support from the international community. The major objective of this study was to conduct a comparative analysis of the effectiveness of green taxes in SA and developed countries. Four countries were chosen for the analysis in this study; South Africa, China, the United States and the United Kingdom. The study depends on secondary analysis obtained from published articles, databases and websites providing research on various organisations and government bodies. From my analysis, this study observed that many developed and developing countries have already implemented environmental taxes, and many other countries are considering similar instruments. The findings of this study are that green taxes and environmental taxes in general, are intended to protect the environment. By levying higher taxes on activities and products that harm the environment, businesses are discouraged from developing industries that destroy nature. Based on the findings, this study recommends that South Africa should address the inconsistencies in its policies across various government departments. The study also recommends the need for tax policy reconsideration so as to improve the relevance of environmental and green taxes. However, the study observed that since South Africa is still hampered by the triple constraints of unemployment, poverty and inequality, and in order to address the negative impacts of carbon taxes, it needs to put in place certain mitigation agreements with high pollution emitting companies. Advisors/Committee Members: Louw, C. (advisor).

Subjects/Keywords: Comparative study; Effectiveness; Green taxes; South Africa; Developed countries; UCTD

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Maphosa, J. M. (2014). A comparative study of effectiveness of green taxes in South Africa and developed countries. (Masters Thesis). University of Pretoria. Retrieved from http://hdl.handle.net/2263/41314

Chicago Manual of Style (16^th Edition):

Maphosa, Jonathan M. “A comparative study of effectiveness of green taxes in South Africa and developed countries.” 2014. Masters Thesis, University of Pretoria. Accessed February 25, 2021. http://hdl.handle.net/2263/41314.

MLA Handbook (7^th Edition):

Maphosa, Jonathan M. “A comparative study of effectiveness of green taxes in South Africa and developed countries.” 2014. Web. 25 Feb 2021.

Vancouver:

Maphosa JM. A comparative study of effectiveness of green taxes in South Africa and developed countries. [Internet] [Masters thesis]. University of Pretoria; 2014. [cited 2021 Feb 25]. Available from: http://hdl.handle.net/2263/41314.

Council of Science Editors:

Maphosa JM. A comparative study of effectiveness of green taxes in South Africa and developed countries. [Masters Thesis]. University of Pretoria; 2014. Available from: http://hdl.handle.net/2263/41314

Addis Ababa University

13. ABRAHAM, BELAY. Factors Which Influence Teaching Effectiveness: A Comparative Analysis of Male and Female Teachers. in Elementary Schools.

Degree: 2012, Addis Ababa University

URL: http://etd.aau.edu.et/dspace/handle/123456789/3837

► The purpose of the study was two-fold. First an effort was made to see if there is a difference between the teaching effectiveness of male… (more)

Subjects/Keywords: TEACHING EFFECTIVENESS; COMPARATIVE ANALYSIS OF MALE AND FEMALE TEACHERS

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

ABRAHAM, B. (2012). Factors Which Influence Teaching Effectiveness: A Comparative Analysis of Male and Female Teachers. in Elementary Schools. (Thesis). Addis Ababa University. Retrieved from http://etd.aau.edu.et/dspace/handle/123456789/3837

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

ABRAHAM, BELAY. “Factors Which Influence Teaching Effectiveness: A Comparative Analysis of Male and Female Teachers. in Elementary Schools. ” 2012. Thesis, Addis Ababa University. Accessed February 25, 2021. http://etd.aau.edu.et/dspace/handle/123456789/3837.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

ABRAHAM, BELAY. “Factors Which Influence Teaching Effectiveness: A Comparative Analysis of Male and Female Teachers. in Elementary Schools. ” 2012. Web. 25 Feb 2021.

Vancouver:

ABRAHAM B. Factors Which Influence Teaching Effectiveness: A Comparative Analysis of Male and Female Teachers. in Elementary Schools. [Internet] [Thesis]. Addis Ababa University; 2012. [cited 2021 Feb 25]. Available from: http://etd.aau.edu.et/dspace/handle/123456789/3837.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

ABRAHAM B. Factors Which Influence Teaching Effectiveness: A Comparative Analysis of Male and Female Teachers. in Elementary Schools. [Thesis]. Addis Ababa University; 2012. Available from: http://etd.aau.edu.et/dspace/handle/123456789/3837

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Toronto

14. Roifman, Idan. Non-invasive Cardiac Diagnostic Tests in Ontario: Temporal Trends in Utilization and Association with Obstructive Coronary Artery Disease.

Degree: 2016, University of Toronto

URL: http://hdl.handle.net/1807/71698

►

Contemporary temporal trends in utilization of graded exercise stress test (GXT), myocardial perfusion scanning (MPI), stress echocardiography (stress echo), and cardiac computed tomography angiography (CCTA)… (more)

Subjects/Keywords: Cardiac imaging; Cardiology; Comparative effectiveness; Epidemiology; Resource utilization; Temporal trends; 0766

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Roifman, I. (2016). Non-invasive Cardiac Diagnostic Tests in Ontario: Temporal Trends in Utilization and Association with Obstructive Coronary Artery Disease. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/71698

Chicago Manual of Style (16^th Edition):

Roifman, Idan. “Non-invasive Cardiac Diagnostic Tests in Ontario: Temporal Trends in Utilization and Association with Obstructive Coronary Artery Disease.” 2016. Masters Thesis, University of Toronto. Accessed February 25, 2021. http://hdl.handle.net/1807/71698.

MLA Handbook (7^th Edition):

Roifman, Idan. “Non-invasive Cardiac Diagnostic Tests in Ontario: Temporal Trends in Utilization and Association with Obstructive Coronary Artery Disease.” 2016. Web. 25 Feb 2021.

Vancouver:

Roifman I. Non-invasive Cardiac Diagnostic Tests in Ontario: Temporal Trends in Utilization and Association with Obstructive Coronary Artery Disease. [Internet] [Masters thesis]. University of Toronto; 2016. [cited 2021 Feb 25]. Available from: http://hdl.handle.net/1807/71698.

Council of Science Editors:

Roifman I. Non-invasive Cardiac Diagnostic Tests in Ontario: Temporal Trends in Utilization and Association with Obstructive Coronary Artery Disease. [Masters Thesis]. University of Toronto; 2016. Available from: http://hdl.handle.net/1807/71698

Harvard University

15. Lin, Joshua. Clinical Pharmacoepidemiology Linking Electronic Health Records With Claims Data.

Degree: Doctor of Science (SD), 2017, Harvard University

URL: http://nrs.harvard.edu/urn-3:HUL.InstRepos:42066817

►

Electronic health records (EHR) and insurance claims databases have been considered cost-effective data sources for conducting comparative effectiveness research (CER) in routine healthcare settings. However,… (more)

▼

Electronic health records (EHR) and insurance claims databases have been considered cost-effective data sources for conducting comparative effectiveness research (CER) in routine healthcare settings. However, these secondary databases have some major limitations. Claims data lack in some clinical information essential for CER. On the other hand, most US EHR systems fail to capture substantial amount of medical information due to care-discontinuity in the study EHR (i.e., receiving care outside of the EHR system). Linking EHR to claims data can supplement the limitations of the individual databases and help combat various biases. In chapter 1, we demonstrated the added value of linking EHR with claims data by developing a prediction score for anticoagulation quality in patients receiving Vitamin K antagonist (VKA) therapy. Anticoagulation quality was shown to have large impact on the effectiveness and safety of VKA therapy and a prediction model for having good anticoagulation quality can be critical for safe and optimal prescribing of VKA. Data in EHR is necessary for ascertaining anticoagulation quality outcomes and some key predictors and the linkage to claims data helps to avoid information bias due to care-discontinuity. In chapter 2, we sought to quantify care-discontinuity in an EHR by comparing encounter records in an EHR with the claims data. Within levels of care-discontinuity, we quantified information bias by comparing classification of CER-relevant variables based on EHR data alone with that based on EHR linked with claims data. We also evaluated whether high care-continuity patients would have representative comorbidity profiles when compared to the remaining population in the EHR. In chapter 3, we aimed to develop and validate algorithms to identify patients with high care-continuity with the predictors available in a typical EHR system. This is important because researchers often need to address information bias caused by care-discontinuity in an EHR without linkage to additional data sources due to privacy and compliance concerns. Our approach may help researchers answer rapidly emerging drug safety and effectiveness questions in a timely fashion with the exponentially growing EHR resources, leveraging rich clinical data while minimizing information bias due to care-discontinuity.

Epidemiology

Advisors/Committee Members: Schneeweiss, Sebastian (advisor), Glynn, Robert J. (committee member), Singer, Daniel E. (committee member).

Subjects/Keywords: Electronic health records; comparative effectiveness research; continuity; discontinuity; information bias

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lin, J. (2017). Clinical Pharmacoepidemiology Linking Electronic Health Records With Claims Data. (Doctoral Dissertation). Harvard University. Retrieved from http://nrs.harvard.edu/urn-3:HUL.InstRepos:42066817

Chicago Manual of Style (16^th Edition):

Lin, Joshua. “Clinical Pharmacoepidemiology Linking Electronic Health Records With Claims Data.” 2017. Doctoral Dissertation, Harvard University. Accessed February 25, 2021. http://nrs.harvard.edu/urn-3:HUL.InstRepos:42066817.

MLA Handbook (7^th Edition):

Lin, Joshua. “Clinical Pharmacoepidemiology Linking Electronic Health Records With Claims Data.” 2017. Web. 25 Feb 2021.

Vancouver:

Lin J. Clinical Pharmacoepidemiology Linking Electronic Health Records With Claims Data. [Internet] [Doctoral dissertation]. Harvard University; 2017. [cited 2021 Feb 25]. Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:42066817.

Council of Science Editors:

Lin J. Clinical Pharmacoepidemiology Linking Electronic Health Records With Claims Data. [Doctoral Dissertation]. Harvard University; 2017. Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:42066817

University of Washington

16. Wang, Wei-Jhih. What guides research investments in translational sciences? The case for pharmaceuticals in metastatic cancers.

Degree: 2015, University of Washington

URL: http://hdl.handle.net/1773/33950

► Background: Understanding strategies that would optimize the impact of biomedical research is important. Prior research has not distinguished between strategizing investments in basic research versus… (more)

▼ Background: Understanding strategies that would optimize the impact of biomedical research is important. Prior research has not distinguished between strategizing investments in basic research versus translational research. Methods: Population-based information on research investments and disease burden in the United States were obtained from publicly available resources such as SEER, National Cancer Statistics Reports and ClinicalTrials.gov. Graphical associations were studied between research investments in translational clinical trials with pharmaceutical drugs for six metastatic cancer sites, approved during 2008 through 2013, and BI-metrics such as 2008 cancer-site specific years-of-life lost (YLL) and historical (2002-2008) and prospective (2008 – 2014) changes in YLL. Associations were explored by study sponsors and by comparative effectiveness trials that include active comparators. Results: Translational research investments were found to be positively associated with anticipated returns based on prospective changes in YLL but negatively associated with the baseline YLL or historical changes in YLL. One exception was non-small cell lung cancer, where the burden was big enough to dominate investments irrespective of returns. Similar patterns in investments were found for both NIH and industry. For trials involving active-comparators or comparative effectiveness trials, positive investment patterns following prospective returns in YLL were found to be more prominent for NIH compared to industry, where incentives for industry are ambiguous. Conclusions and Relevance: Investments in translational research in metastatic cancers, especially in NIH, appeared to follow prospective changes in YLL rather than YLL themselves. This is line with the theories of investment decision-making under uncertainty. Developing and using quantitative measures such as expected value of information metrics can further help guide these decisions and create a more productive dialogue on research investments across stakeholders. Advisors/Committee Members: Basu, Anirban (advisor).

Subjects/Keywords: cancer; comparative effectiveness; disease burden; research investments; Health sciences; health services

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wang, W. (2015). What guides research investments in translational sciences? The case for pharmaceuticals in metastatic cancers. (Thesis). University of Washington. Retrieved from http://hdl.handle.net/1773/33950

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wang, Wei-Jhih. “What guides research investments in translational sciences? The case for pharmaceuticals in metastatic cancers.” 2015. Thesis, University of Washington. Accessed February 25, 2021. http://hdl.handle.net/1773/33950.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wang, Wei-Jhih. “What guides research investments in translational sciences? The case for pharmaceuticals in metastatic cancers.” 2015. Web. 25 Feb 2021.

Vancouver:

Wang W. What guides research investments in translational sciences? The case for pharmaceuticals in metastatic cancers. [Internet] [Thesis]. University of Washington; 2015. [cited 2021 Feb 25]. Available from: http://hdl.handle.net/1773/33950.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wang W. What guides research investments in translational sciences? The case for pharmaceuticals in metastatic cancers. [Thesis]. University of Washington; 2015. Available from: http://hdl.handle.net/1773/33950

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

17. CASSIDY, OWEN CHRISTOPHER. Matching-adjusted indirect comparisons: identifying method variations and implementing models in R.

Degree: School of Computer Science & Statistics. Discipline of Statistics, 2020, Trinity College Dublin

URL: http://hdl.handle.net/2262/92678

► In the framework of evidence-based medicine, comparative effectiveness research is a fundamental activity to the development of pharmaceutical products and medical treatments. For a given… (more)

Subjects/Keywords: evidence synthesis; matching-adjusted indirect comparison; comparative effectiveness research; R package

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

CASSIDY, O. C. (2020). Matching-adjusted indirect comparisons: identifying method variations and implementing models in R. (Thesis). Trinity College Dublin. Retrieved from http://hdl.handle.net/2262/92678

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

CASSIDY, OWEN CHRISTOPHER. “Matching-adjusted indirect comparisons: identifying method variations and implementing models in R.” 2020. Thesis, Trinity College Dublin. Accessed February 25, 2021. http://hdl.handle.net/2262/92678.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

CASSIDY, OWEN CHRISTOPHER. “Matching-adjusted indirect comparisons: identifying method variations and implementing models in R.” 2020. Web. 25 Feb 2021.

Vancouver:

CASSIDY OC. Matching-adjusted indirect comparisons: identifying method variations and implementing models in R. [Internet] [Thesis]. Trinity College Dublin; 2020. [cited 2021 Feb 25]. Available from: http://hdl.handle.net/2262/92678.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

CASSIDY OC. Matching-adjusted indirect comparisons: identifying method variations and implementing models in R. [Thesis]. Trinity College Dublin; 2020. Available from: http://hdl.handle.net/2262/92678

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Toronto

18. Tadrous, Mina. Advancing Comparative Effectiveness Research: Filling in the Gaps for Bisphosphonates.

Degree: PhD, 2015, University of Toronto

URL: http://hdl.handle.net/1807/89017

►

Drug approval regulations for market-entry often only require that medications be proven efficacious compared to placebo. This drug approval policy creates a gap in information… (more)

Subjects/Keywords: Bisphosphonates; Comparative Effectiveness; Health Outcomes; Medications; Pharmacoepidemiology; Pharmacy; 0766

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tadrous, M. (2015). Advancing Comparative Effectiveness Research: Filling in the Gaps for Bisphosphonates. (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/89017

Chicago Manual of Style (16^th Edition):

Tadrous, Mina. “Advancing Comparative Effectiveness Research: Filling in the Gaps for Bisphosphonates.” 2015. Doctoral Dissertation, University of Toronto. Accessed February 25, 2021. http://hdl.handle.net/1807/89017.

MLA Handbook (7^th Edition):

Tadrous, Mina. “Advancing Comparative Effectiveness Research: Filling in the Gaps for Bisphosphonates.” 2015. Web. 25 Feb 2021.

Vancouver:

Tadrous M. Advancing Comparative Effectiveness Research: Filling in the Gaps for Bisphosphonates. [Internet] [Doctoral dissertation]. University of Toronto; 2015. [cited 2021 Feb 25]. Available from: http://hdl.handle.net/1807/89017.

Council of Science Editors:

Tadrous M. Advancing Comparative Effectiveness Research: Filling in the Gaps for Bisphosphonates. [Doctoral Dissertation]. University of Toronto; 2015. Available from: http://hdl.handle.net/1807/89017

University of Washington

19. Dickerson, John F. Role of Patient Adherence in the Treatment and Prevention of Depression.

Degree: PhD, 2015, University of Washington

URL: http://hdl.handle.net/1773/27498

► Patient adherence to treatment and prevention guidelines as part of depression care is complex process. Major depression is a common disorder that can cause substantial… (more)

▼ Patient adherence to treatment and prevention guidelines as part of depression care is complex process. Major depression is a common disorder that can cause substantial morbidity, increase risks of mortality, negatively impact social relationships, and influence long term trajectories of education attainment and labor market outcome. Adherence is an important aspect of depression care because variability in compliance with prescribed treatments contributes to treatment effect heterogeneity and thus can decrease the effectiveness of viable treatments. This dissertation provides research to better understand barriers to pharmacotherapy and effects of patient adherence on health services use and health outcomes. Results from this project provide important information about characteristics of adherence and demonstrate the potential benefit allocating resources towards improving patient adherence for depression treatment and prevention. This dissertation examined determinants and consequences of adherence from different perspectives using observational data extracted from electronic medical records of a large integrated managed care maintenance organization as well as clinical trial data from a large multisite study. In the first aim of the dissertation, we studied the effects of industry-level unemployment on antidepressant pharmacotherapy using methods to control multiple channels of bias. We used medication persistence as our dependent variable, which measures the amount of time a patient accumulates medication from the beginning of therapy to discontinuation. We found empirical evidence that industry-level economic contraction interfered with optimal antidepressant therapy. In addition, we found the effect to be most pronounced during periods of economic shock and among mid-career employees. The second aim of this dissertation, we examined the effects of antidepressant adherence and persistence on medical care expenditures, also controlling for multiple sources of bias. We found a small but significant effect of antidepressant persistence on total costs excluding medications and on the costs of outpatient services. As persistence increased, our measures of medical care expenditures decreased. We conducted a longer-term economic evaluation of a clinical trial testing clinical- and cost-effectiveness of a depression prevention program and examined the effect of intervention dose on economic outcomes as part of the third and final aim of this dissertation. We demonstrated longer-term cost-effectiveness of the depression prevention program and showed higher doses of the intervention resulted in more favorable measures of cost-effectiveness. Our research signals the potential benefit of additional adherence promotion as part of an existing intervention program. Each aim in this dissertation project contributed policy-relevant research about barriers to patient adherence or about the effects of adherence on important patient outcomes. We applied rigorous quantitative methods to establish causality in our… Advisors/Committee Members: Basu, Anirban (advisor).

Subjects/Keywords: Adherence; Bias; Comparative Effectiveness; Cost Effectiveness; Instrumental Variable; Mental Health; Public health; Economics; Statistics; health services

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dickerson, J. F. (2015). Role of Patient Adherence in the Treatment and Prevention of Depression. (Doctoral Dissertation). University of Washington. Retrieved from http://hdl.handle.net/1773/27498

Chicago Manual of Style (16^th Edition):

Dickerson, John F. “Role of Patient Adherence in the Treatment and Prevention of Depression.” 2015. Doctoral Dissertation, University of Washington. Accessed February 25, 2021. http://hdl.handle.net/1773/27498.

MLA Handbook (7^th Edition):

Dickerson, John F. “Role of Patient Adherence in the Treatment and Prevention of Depression.” 2015. Web. 25 Feb 2021.

Vancouver:

Dickerson JF. Role of Patient Adherence in the Treatment and Prevention of Depression. [Internet] [Doctoral dissertation]. University of Washington; 2015. [cited 2021 Feb 25]. Available from: http://hdl.handle.net/1773/27498.

Council of Science Editors:

Dickerson JF. Role of Patient Adherence in the Treatment and Prevention of Depression. [Doctoral Dissertation]. University of Washington; 2015. Available from: http://hdl.handle.net/1773/27498

University of Kentucky

20. Sohn, Minji. THE OFF-LABEL USE OF ATYPICAL ANTIPSYCHOTICS AND ITS IMPACT ON ATTENTION DEFICIT/HYPERACTIVITY DISORDER (ADHD).

Degree: 2014, University of Kentucky

URL: https://uknowledge.uky.edu/pharmacy_etds/33

► Atypical antipsychotics (AAPs) (also known as second-generation antipsychotics) are the US Food and Drug Administration (FDA) approved medications for schizophrenia, bipolar I disorder, depression and… (more)

▼ Atypical antipsychotics (AAPs) (also known as second-generation antipsychotics) are the US Food and Drug Administration (FDA) approved medications for schizophrenia, bipolar I disorder, depression and autism. Compared to the typical antipsychotics, AAPs were marketed as reducing adverse side effects such as extrapyramidal symptoms. This resulted in extensive use of AAPs for not only the FDA approved indications but also other conditions that are not approved. However, several post-marketing clinical trials evaluated the use of AAPs and reported serious adverse side effects, including metabolic syndrome, cardiovascular events, or death. The extensive use of AAPs by pediatrics is an important policy problem that imposes serious concerns on public health and economy in the US. A large proportion of total pediatric AAP use is off-label in which the safety and effectiveness are not yet established. Moreover, among the off-label conditions for which AAPs were used, ADHD was the most common primary mental diagnosis. From public health perspective, the risk of type II diabetes in pediatric AAP users was estimated. A retrospective cohort study was conducted and a twice higher risk of developing type II diabetes was estimated for AAP users compared to non-users in pediatrics. From economic efficiency perspective, the cost-effectiveness of AAPs compared to other ADHD medications in pediatric ADHD patients was estimated. Among non-stimulant ADHD medication treatment strategies, AAPs resulted in the lower expected health outcome than other ADHD medications. Also, AAPs were not a favored choice with respect to cost-effectiveness. A comparative effectiveness study that compares resource utilization and costs between atypical antipsychotic (AAP) users and non-AAP users in ADHD revealed that AAP users were likely to visit a healthcare facility for outpatient and inpatient services more frequently than non-AAP users. Total health care costs were significantly higher for AAP users with additional costs of 1,393 (2012 dollars) during six months and 2,784 (2012 dollars) during a year after initiating the AAP treatment.

Subjects/Keywords: Atypical antipsychotics (AAPs); Attention-deficit/hyperactivity disorder (ADHD); Type II diabetes (T2DM); Cost-effectiveness; Comparative effectiveness; Psychiatric and Mental Health

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sohn, M. (2014). THE OFF-LABEL USE OF ATYPICAL ANTIPSYCHOTICS AND ITS IMPACT ON ATTENTION DEFICIT/HYPERACTIVITY DISORDER (ADHD). (Doctoral Dissertation). University of Kentucky. Retrieved from https://uknowledge.uky.edu/pharmacy_etds/33

Chicago Manual of Style (16^th Edition):

Sohn, Minji. “THE OFF-LABEL USE OF ATYPICAL ANTIPSYCHOTICS AND ITS IMPACT ON ATTENTION DEFICIT/HYPERACTIVITY DISORDER (ADHD).” 2014. Doctoral Dissertation, University of Kentucky. Accessed February 25, 2021. https://uknowledge.uky.edu/pharmacy_etds/33.

MLA Handbook (7^th Edition):

Sohn, Minji. “THE OFF-LABEL USE OF ATYPICAL ANTIPSYCHOTICS AND ITS IMPACT ON ATTENTION DEFICIT/HYPERACTIVITY DISORDER (ADHD).” 2014. Web. 25 Feb 2021.

Vancouver:

Sohn M. THE OFF-LABEL USE OF ATYPICAL ANTIPSYCHOTICS AND ITS IMPACT ON ATTENTION DEFICIT/HYPERACTIVITY DISORDER (ADHD). [Internet] [Doctoral dissertation]. University of Kentucky; 2014. [cited 2021 Feb 25]. Available from: https://uknowledge.uky.edu/pharmacy_etds/33.

Council of Science Editors:

Sohn M. THE OFF-LABEL USE OF ATYPICAL ANTIPSYCHOTICS AND ITS IMPACT ON ATTENTION DEFICIT/HYPERACTIVITY DISORDER (ADHD). [Doctoral Dissertation]. University of Kentucky; 2014. Available from: https://uknowledge.uky.edu/pharmacy_etds/33

21. Louie, A.V. Optimizing Patient Selection in Stereotactic Ablative Radiotherapy for Early Stage NSCLC through Comparative Effectiveness Research .

Degree: 2016, Vrije Universiteit Amsterdam

URL: http://hdl.handle.net/1871/54467

Subjects/Keywords: lung cancer; stereotactic radiation; comparative effectiveness

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Louie, A. V. (2016). Optimizing Patient Selection in Stereotactic Ablative Radiotherapy for Early Stage NSCLC through Comparative Effectiveness Research . (Doctoral Dissertation). Vrije Universiteit Amsterdam. Retrieved from http://hdl.handle.net/1871/54467

Chicago Manual of Style (16^th Edition):

Louie, A V. “Optimizing Patient Selection in Stereotactic Ablative Radiotherapy for Early Stage NSCLC through Comparative Effectiveness Research .” 2016. Doctoral Dissertation, Vrije Universiteit Amsterdam. Accessed February 25, 2021. http://hdl.handle.net/1871/54467.

MLA Handbook (7^th Edition):

Louie, A V. “Optimizing Patient Selection in Stereotactic Ablative Radiotherapy for Early Stage NSCLC through Comparative Effectiveness Research .” 2016. Web. 25 Feb 2021.

Vancouver:

Louie AV. Optimizing Patient Selection in Stereotactic Ablative Radiotherapy for Early Stage NSCLC through Comparative Effectiveness Research . [Internet] [Doctoral dissertation]. Vrije Universiteit Amsterdam; 2016. [cited 2021 Feb 25]. Available from: http://hdl.handle.net/1871/54467.

Council of Science Editors:

Louie AV. Optimizing Patient Selection in Stereotactic Ablative Radiotherapy for Early Stage NSCLC through Comparative Effectiveness Research . [Doctoral Dissertation]. Vrije Universiteit Amsterdam; 2016. Available from: http://hdl.handle.net/1871/54467

University of Washington

22. Finnell, John Spencer. Strategies for Repletion of Vitamin D Nutritional Deficiency: A Comparative Effectiveness Trial of High-quality Vitamin D3 Nutritional Supplements to Replete Serum Vitamin D.

Degree: 2013, University of Washington

URL: http://hdl.handle.net/1773/21902

► Background: Vitamin insufficiency and deficiency may be associated with increased risk for cardiovascular disease, diabetes, some cancers and all cause mortality. Practice guidelines define sufficient… (more)

▼ Background: Vitamin insufficiency and deficiency may be associated with increased risk for cardiovascular disease, diabetes, some cancers and all cause mortality. Practice guidelines define sufficient vitamin D status as a serum 25-hydroxycholecalciferol (25-OHD) concentration >30 ng/mL (70 nmol/L). Supplementation strategies to safely achieve vitamin D sufficiency are needed. Objective: We evaluated the change in serum 25-OHD concentrations after supplementation with three commercially available vitamin D3 products with different vehicles of delivery: a chewable tablet; a liquid drop; and a encapsulated powder. Methods: The clinical trial design was a prospective, randomized, pragmatic, comparative effectiveness study of vitamin D3 supplementation. We conducted third-party analysis of the three commercially available vitamin D3 supplements used in this trial. Subjects were provisioned informed consent and randomized to one of the three vitamin D3 supplements, dosed at 10,000 IU per day for 12 weeks, per label claim. Results: Eligible subjects (n=66) were enrolled in the study, of which 11 subjects were lost to follow up (17%). 100% of the subjects in the tablet and capsule allocation arms attained sufficient vitamin D status, compared to 80% in the oil drop arm. The mean (±SD) change in 25-OHD (ng/mL) from baseline to week 12 reached the level of statistical significance (p<0.001) for each of the three allocation groups: tablet (n=18); 31.8 (7.6); oil drop (n=20); 32.2 (8.0); and capsule (n=17); 48.1 (8.1). Between group changes in serum 25-OHD were also significant (ANOVA; p<0.05). While pairwise-comparisons of changes in serum 25-OHD showed a statistically significant difference, distinguishing Group C from Groups A and B (Tukey's Test; p<0.05). Three non-serious adverse events occurred during the study, without observed hypercalcemia or hypervitaminosis D. Discussion: We observed variability in vitamin D3 concentration in the three supplements, with the tablet and capsule showing increased D3 concentration, compared to label claim. The majority of subjects (93%) achieved sufficient 25-OHD status at the end of the study. We conclude that 10,000 IU vitamin D3 per day for 12-weeks may be a safe and effective strategy for vitamin D supplementation to correct nutritional deficiency in 25-OHD insufficient populations. This trial was registered at clinicaltrials.gov as NCT01524874. Advisors/Committee Members: Lampe, Johanna W (advisor).

Subjects/Keywords: cholecalciferol; comparative effectiveness; dietary supplements; nutritional deficiency; vitamin D; Nutrition; Medicine; Epidemiology

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Finnell, J. S. (2013). Strategies for Repletion of Vitamin D Nutritional Deficiency: A Comparative Effectiveness Trial of High-quality Vitamin D3 Nutritional Supplements to Replete Serum Vitamin D. (Thesis). University of Washington. Retrieved from http://hdl.handle.net/1773/21902

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Finnell, John Spencer. “Strategies for Repletion of Vitamin D Nutritional Deficiency: A Comparative Effectiveness Trial of High-quality Vitamin D3 Nutritional Supplements to Replete Serum Vitamin D.” 2013. Thesis, University of Washington. Accessed February 25, 2021. http://hdl.handle.net/1773/21902.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Finnell, John Spencer. “Strategies for Repletion of Vitamin D Nutritional Deficiency: A Comparative Effectiveness Trial of High-quality Vitamin D3 Nutritional Supplements to Replete Serum Vitamin D.” 2013. Web. 25 Feb 2021.

Vancouver:

Finnell JS. Strategies for Repletion of Vitamin D Nutritional Deficiency: A Comparative Effectiveness Trial of High-quality Vitamin D3 Nutritional Supplements to Replete Serum Vitamin D. [Internet] [Thesis]. University of Washington; 2013. [cited 2021 Feb 25]. Available from: http://hdl.handle.net/1773/21902.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Finnell JS. Strategies for Repletion of Vitamin D Nutritional Deficiency: A Comparative Effectiveness Trial of High-quality Vitamin D3 Nutritional Supplements to Replete Serum Vitamin D. [Thesis]. University of Washington; 2013. Available from: http://hdl.handle.net/1773/21902

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

23. Bhattacharya, Kaustuv. Multiple Myeloma – Treatments, Economic Burden, And End Of Life Care.

Degree: PhD, Pharmaceutical Sciences, 2020, University of Mississippi

URL: https://egrove.olemiss.edu/etd/1812

► This dissertation aimed at filling the gaps in the body of multiple myeloma (MM) literature by comparing overall survival and safety of first line maintenance… (more)

▼ This dissertation aimed at filling the gaps in the body of multiple myeloma (MM) literature by comparing overall survival and safety of first line maintenance or continuous treatment, and assessing disease lifetime costs, phase-specific costs and its drivers among elderly newly diagnosed (NDMM) patients. Moreover, it aimed to assess trends in EOL care and the impact of PCC on EOL care outcomes among elderly MM patients. First, this study assessed the comparative safety and effectiveness among those who received first line LEN-based treatment versus those who received first line BORT-based treatment. The results from the study demonstrates an overall survival benefit and similar toxicity risk for patients receiving first line LEN-based continuous or maintenance treatment over those who received first line BORT-based treatment. Further, the study results highlighted the substantial economic burden associated with MM care, in spite of the disease having low prevalence as compared to some of the other cancers. The incremental phase-specific costs were highest for the initial care phase, followed by the terminal phase, with costs being slightly lower for the continuing care phase, and lowest for the pre-diagnosis phase. Inpatient and outpatient costs were the major drivers of costs in all the four phases. Pharmacy costs were a significant driver of costs in the initial and terminal phases, and were the biggest cost driver in the continuing care phase. Last, it assessed trends in aggressiveness of EOL care outcomes over time. While certain indicators of aggressive EOL care remained stable over time, we observed an increasing trend for multiple ED visits and ICU stays. Moreover, this study assessed the impact of palliative care consultations on receiving aggressive EOL care, and healthcare resource use and costs at EOL. Results indicate that early palliative care consultations have the potential to reduce aggressive EOL care, and curtail healthcare resource use and costs at EOL. Study findings about clinical and economic outcomes will help inform clinicians’ treatment decisions, aid policy discussions regarding MM care and coverage, and help design interventions to integrate early palliative care into routine care among elderly MM patients. Advisors/Committee Members: Yi Yang, Ruchit Shah, Sujith Ramachandran.

Subjects/Keywords: comparative effectiveness; economic burden; end of life care; multiple myeloma; palliative care; safety

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bhattacharya, K. (2020). Multiple Myeloma – Treatments, Economic Burden, And End Of Life Care. (Doctoral Dissertation). University of Mississippi. Retrieved from https://egrove.olemiss.edu/etd/1812

Chicago Manual of Style (16^th Edition):

Bhattacharya, Kaustuv. “Multiple Myeloma – Treatments, Economic Burden, And End Of Life Care.” 2020. Doctoral Dissertation, University of Mississippi. Accessed February 25, 2021. https://egrove.olemiss.edu/etd/1812.

MLA Handbook (7^th Edition):

Bhattacharya, Kaustuv. “Multiple Myeloma – Treatments, Economic Burden, And End Of Life Care.” 2020. Web. 25 Feb 2021.

Vancouver:

Bhattacharya K. Multiple Myeloma – Treatments, Economic Burden, And End Of Life Care. [Internet] [Doctoral dissertation]. University of Mississippi; 2020. [cited 2021 Feb 25]. Available from: https://egrove.olemiss.edu/etd/1812.

Council of Science Editors:

Bhattacharya K. Multiple Myeloma – Treatments, Economic Burden, And End Of Life Care. [Doctoral Dissertation]. University of Mississippi; 2020. Available from: https://egrove.olemiss.edu/etd/1812

Curtin University of Technology

24. Iyer, Radha. Investigating the effectiveness of an online course : development of the comparative learning environment questionnaire .

Degree: 2011, Curtin University of Technology

URL: http://hdl.handle.net/20.500.11937/1538

► This study was undertaken with the purpose of evaluating a newly-developed online course. The study involved, firstly, designing, developing and validating two questionnaires that could… (more)

▼ This study was undertaken with the purpose of evaluating a newly-developed online course. The study involved, firstly, designing, developing and validating two questionnaires that could be used to assess the relative effectiveness of the online course in terms of students’ perceptions of the learning environment and attitudes. The development of the learning environment instrument drew on and extended the wide array of already validated instruments in the field of learning environments. The development used a multi-stage approach that included a review of pertinent literature, identifying salient scales and developing pertinent survey items. Both surveys were field tested and refinements were made on the basis of the findings. Its unique format allowed the comparison of the newly-developed online course with a parallel face-to-face course. The learning environment survey assesses the six scales of Task Orientation, Responsibility and Independence, Access, Computer Usage, Authentic Learning, Information Design and Appeal and the attitude instrument is comprised of three scales, namely, Student Enjoyment, Academic Efficacy and Anxiety.The learning environment survey and attitude survey were administered to 1000 students, of whom 991 provided complete and usable responses. Analyses of the data obtained from 991 students were conducted to support the factorial validity and internal consistency reliability of both the learning environment and attitude instruments. For the learning environment instrument, principal axis factoring with varimax rotation (conducted separately for the online and face-to-face course) confirmed that, without exception, all items had a factor loading of at least 0.40 on their a priori scale and no other scale. The scale reliability estimates were high for both versions of the learning environment instrument, ranging from 0.85 to 0.92 for the online course and from 0.85 to 0.91 for the face-to-face environment. The attitude instrument also was found to be reliable. Factor analysis confirmed the a priori structure of the student attitudes instrument for the online and face-to-face courses comprising 18 items in three scales. All items had a factor loading of at least 0.40 on their a priori scale and no other scale. The Cronbach alpha coefficient for the online and face-to-face course for each of the three attitude scales ranged from 0.91 to 0.95 for online course and from 0.91 to 0.96 for face-to-face course.Qualitative information from focus-group interviews with 90 students were used to supplement and support the quantitative results. Interview data collected from 90 students who took part in the semi-structured interviews and focus-group discussions helped to confirm and provide reasons for the quantitative findings that students generally had more positive views of their online course than the face-to-face course.Data collected using the learning environment and attitude surveys were used to compare students’ scores for the online and face-to-face courses using MANOVA. The results indicated…

Subjects/Keywords: pertinent survey; effectiveness of an online course; salient scales; comparative learning environment questionnaire; pertinent literature

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Iyer, R. (2011). Investigating the effectiveness of an online course : development of the comparative learning environment questionnaire . (Thesis). Curtin University of Technology. Retrieved from http://hdl.handle.net/20.500.11937/1538

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Iyer, Radha. “Investigating the effectiveness of an online course : development of the comparative learning environment questionnaire .” 2011. Thesis, Curtin University of Technology. Accessed February 25, 2021. http://hdl.handle.net/20.500.11937/1538.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Iyer, Radha. “Investigating the effectiveness of an online course : development of the comparative learning environment questionnaire .” 2011. Web. 25 Feb 2021.

Vancouver:

Iyer R. Investigating the effectiveness of an online course : development of the comparative learning environment questionnaire . [Internet] [Thesis]. Curtin University of Technology; 2011. [cited 2021 Feb 25]. Available from: http://hdl.handle.net/20.500.11937/1538.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Iyer R. Investigating the effectiveness of an online course : development of the comparative learning environment questionnaire . [Thesis]. Curtin University of Technology; 2011. Available from: http://hdl.handle.net/20.500.11937/1538

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

The Ohio State University

25. Fluegge, Kyle. Effects of Patient Self-Selection on Costs to Treat Latent Tuberculosis Infection (LTBI).

Degree: PhD, Agricultural, Environmental and Developmental Economics, 2014, The Ohio State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1388665018

► The first paper uses a series of probit models to examine patient demand for isoniazid preventative therapy (9INH) for treatment of latent tuberculosis infection (LTBI)… (more)

▼ The first paper uses a series of probit models to examine patient demand for isoniazid preventative therapy (9INH) for treatment of latent tuberculosis infection (LTBI) in an ethnically diverse clinic population. I produce an economic model of LTBI adherence that describes the value of immunity via acquired (treatment with 9INH therapy) or innate (no therapeutic intervention) means. The value of acquired versus innate immunity to TB depends on four factors: TB contact potential, immuno-compromised status, duration and acculturation status. This theoretical model is tested with clinic data. Results reveal that patients who have a greater contact potential are less likely to complete LTBI therapy (p < 0.05), while patients with diabetes are more likely to complete (p < 0.05). Immigration status negatively affects completion, while acculturation positively affects adherence (p < 0.05). The second paper uses a series of selection models to examine the costs to treat LTBI. I use a series of generalized Tobit models with random effects to control for individual heterogeneity to isolate the contribution of genetic effects to the monthly costs to treat patients who experience side effects to 9INH. I am able to estimate the differences in 9INH treatment costs between ethnic groups that feature distinct genetic predispositions to suffer side effects from 9INH. Results reveal that self-selection is present in this clinic data, although the classic Heckman two-step estimator is inappropriate to correctly capture this effect. I use a semi-parametric selection estimator and compare results with the Heckman estimator. Predictive capacity modeling shows that an ordered probit selection rule with parametric estimator is the optimal methodology to account for selection. The final paper uses a series of multilevel semi-parametric selection models to examine the comparative-effectiveness and absolute-effectiveness of isoniazid therapy (9INH) for treatment of LTBI. The comparative models incorporate random effects designed to control for individual heterogeneity and semi-parametric selection estimators to isolate the contribution of genetic effects to the total costs to treat. To analyze absolute effectiveness, I simulate cost-effectiveness ratios of an alternative therapy consisting of four months of rifampin (4RIF), a drug known to cause few side effects. I compare these ratios with bootstrapped confidence intervals of the cost-effectiveness ratios for 9INH within each ethnic group. Results reveal wide variations in the comparative effectiveness of 9INH across ethnic groups and biased results when the commonly employed case deletion methodology is used. For absolute effectiveness, 4RIF is cost-effective across all simulation scenarios for all patient groups, except for Asians. Advisors/Committee Members: Roe, Brian (Advisor).

Subjects/Keywords: Health Sciences; Social Research; Economics; latent tuberculosis infection, self-selection, comparative effectiveness

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Fluegge, K. (2014). Effects of Patient Self-Selection on Costs to Treat Latent Tuberculosis Infection (LTBI). (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1388665018

Chicago Manual of Style (16^th Edition):

Fluegge, Kyle. “Effects of Patient Self-Selection on Costs to Treat Latent Tuberculosis Infection (LTBI).” 2014. Doctoral Dissertation, The Ohio State University. Accessed February 25, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu1388665018.

MLA Handbook (7^th Edition):

Fluegge, Kyle. “Effects of Patient Self-Selection on Costs to Treat Latent Tuberculosis Infection (LTBI).” 2014. Web. 25 Feb 2021.

Vancouver:

Fluegge K. Effects of Patient Self-Selection on Costs to Treat Latent Tuberculosis Infection (LTBI). [Internet] [Doctoral dissertation]. The Ohio State University; 2014. [cited 2021 Feb 25]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1388665018.

Council of Science Editors:

Fluegge K. Effects of Patient Self-Selection on Costs to Treat Latent Tuberculosis Infection (LTBI). [Doctoral Dissertation]. The Ohio State University; 2014. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1388665018

Harvard University

26. Garabedian, Laura Faden. Quasi-Experimental Health Policy Research: Evaluation of Universal Health Insurance and Methods for Comparative Effectiveness Research.

Degree: PhD, Health Policy, 2013, Harvard University

URL: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11156786

► This dissertation consists of two empirical papers and one methods paper. The first two papers use quasi-experimental methods to evaluate the impact of universal health… (more)

Subjects/Keywords: Health care management; Statistics; Public policy; Comparative Effectiveness Research; Health Insurance; Health Policy; Policy Evaluation; Quasi-experimental Research Design; Statistics

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Garabedian, L. F. (2013). Quasi-Experimental Health Policy Research: Evaluation of Universal Health Insurance and Methods for Comparative Effectiveness Research. (Doctoral Dissertation). Harvard University. Retrieved from http://nrs.harvard.edu/urn-3:HUL.InstRepos:11156786

Chicago Manual of Style (16^th Edition):

Garabedian, Laura Faden. “Quasi-Experimental Health Policy Research: Evaluation of Universal Health Insurance and Methods for Comparative Effectiveness Research.” 2013. Doctoral Dissertation, Harvard University. Accessed February 25, 2021. http://nrs.harvard.edu/urn-3:HUL.InstRepos:11156786.

MLA Handbook (7^th Edition):

Garabedian, Laura Faden. “Quasi-Experimental Health Policy Research: Evaluation of Universal Health Insurance and Methods for Comparative Effectiveness Research.” 2013. Web. 25 Feb 2021.

Vancouver:

Garabedian LF. Quasi-Experimental Health Policy Research: Evaluation of Universal Health Insurance and Methods for Comparative Effectiveness Research. [Internet] [Doctoral dissertation]. Harvard University; 2013. [cited 2021 Feb 25]. Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11156786.

Council of Science Editors:

Garabedian LF. Quasi-Experimental Health Policy Research: Evaluation of Universal Health Insurance and Methods for Comparative Effectiveness Research. [Doctoral Dissertation]. Harvard University; 2013. Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11156786

University of Wisconsin – Milwaukee

27. Ravvaz, Kourosh. Facilitating and Enhancing Biomedical Knowledge Translation: An in Silico Approach to Patient-centered Pharmacogenomic Outcomes Research.

Degree: PhD, Biomedical and Health Informatics, 2015, University of Wisconsin – Milwaukee

URL: https://dc.uwm.edu/etd/914

► Current research paradigms such as traditional randomized control trials mostly rely on relatively narrow efficacy data which results in high internal validity and low… (more)

Subjects/Keywords: Clinical Trial; Comparative-Effectiveness; Patient-Centered Outcomes; Pharmacogenomics; Simulation; Translational Research; Bioinformatics; Library and Information Science; Medicine and Health Sciences

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ravvaz, K. (2015). Facilitating and Enhancing Biomedical Knowledge Translation: An in Silico Approach to Patient-centered Pharmacogenomic Outcomes Research. (Doctoral Dissertation). University of Wisconsin – Milwaukee. Retrieved from https://dc.uwm.edu/etd/914

Chicago Manual of Style (16^th Edition):

Ravvaz, Kourosh. “Facilitating and Enhancing Biomedical Knowledge Translation: An in Silico Approach to Patient-centered Pharmacogenomic Outcomes Research.” 2015. Doctoral Dissertation, University of Wisconsin – Milwaukee. Accessed February 25, 2021. https://dc.uwm.edu/etd/914.

MLA Handbook (7^th Edition):

Ravvaz, Kourosh. “Facilitating and Enhancing Biomedical Knowledge Translation: An in Silico Approach to Patient-centered Pharmacogenomic Outcomes Research.” 2015. Web. 25 Feb 2021.

Vancouver:

Ravvaz K. Facilitating and Enhancing Biomedical Knowledge Translation: An in Silico Approach to Patient-centered Pharmacogenomic Outcomes Research. [Internet] [Doctoral dissertation]. University of Wisconsin – Milwaukee; 2015. [cited 2021 Feb 25]. Available from: https://dc.uwm.edu/etd/914.

Council of Science Editors:

Ravvaz K. Facilitating and Enhancing Biomedical Knowledge Translation: An in Silico Approach to Patient-centered Pharmacogenomic Outcomes Research. [Doctoral Dissertation]. University of Wisconsin – Milwaukee; 2015. Available from: https://dc.uwm.edu/etd/914

Freie Universität Berlin

28. Blödt, Susanne. Comparative effectiveness research in Chinese Medicine.

Degree: 2017, Freie Universität Berlin

URL: https://refubium.fu-berlin.de/handle/fub188/10573

► Background/Aim: CER aims to generate results which are applicable in regular medical care. The thesis has three primary aims: (1) Development and implementation of a… (more)

▼ Background/Aim: CER aims to generate results which are applicable in regular medical care. The thesis has three primary aims: (1) Development and implementation of a stakeholder process within a randomized pragmatic trial on acupressure for menstrual pain (AKUD-study), (2) a qualitative assessment of the reasons for participation in the AKUD-study and of the influence of financial compensation on the decision-making process, (3) Evaluation of the effectiveness of Qigong compared to exercise therapy in patients with chronic lower back pain (LBP). Methods: (1) Mixed-methods were used to engage stakeholders in the design of the study. Based on the results of a survey and focus group discussion with affected women a stakeholder advisory group designed the study. (2) Semistructured interviews were conducted with 25 out of 220 participants of AKUD. Of those, 10 women knew about the financial compensation at the time of recruitment. Sampling was purposeful. Selection criteria included time of recruitment and group allocation. (3) 127 patients with chronic LBP were randomized and received either Qigong (64 patients) or exercise therapy (63 patients) over 12 weeks. A non-inferiority hypothesis was tested. The primary outcome was the mean pain intensity in the last 7 days (VAS, 0-100 mm, 0 = no pain, 100 = worst imaginable pain, non-inferiority margin = 5 mm) at 3 months. Results: (1) Engagement of stakeholders resulted in a two-armed AKUD study that included women 18-25 years of age and used a smartphone app as an intervention and data-collecting tool. (2) The women were dissatisfied with the treatment options for menstrual pain and the AKUD-app offered with acupressure a non-pharmacological alternative. A further reason to participate in the AKUD-study was the desire to add a new therapy to medical care. The financial compensation was a subsidiary reason for study participation in the women’s narratives. (3) Mean pain intensity of LBP decreased in both groups after 3 months (Qigong 34.8 mm; 95% Confidence interval (CI): [29.5;40.2]; exercise: 33.1 mm [95% CI: 27.7;38.4]). Difference between groups was -1.8 mm (95 % CI: [-9.4;5.8]). Non-inferiority failed to show statistical significance (p=0.204). Discussion: (1) The stakeholder process had a relevant influence on the study design. The addition of medical options to care played an important role in the decision-making, whereas financial incentives played a minor role. (2) The study results of AKUD need to be published to evaluate the relevance of acupressure for menstrual pain. (3) Non-Inferiority of Qigong compared to exercise therapy could not be proven (p=0.204). Advisors/Committee Members: [email protected] (contact), w (gender), N.N. (firstReferee), N.N. (furtherReferee).

Subjects/Keywords: comparative effectiveness research; acupuncture; acupressure; menstrual pain; chronic low back pain; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Blödt, S. (2017). Comparative effectiveness research in Chinese Medicine. (Thesis). Freie Universität Berlin. Retrieved from https://refubium.fu-berlin.de/handle/fub188/10573

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Blödt, Susanne. “Comparative effectiveness research in Chinese Medicine.” 2017. Thesis, Freie Universität Berlin. Accessed February 25, 2021. https://refubium.fu-berlin.de/handle/fub188/10573.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Blödt, Susanne. “Comparative effectiveness research in Chinese Medicine.” 2017. Web. 25 Feb 2021.

Vancouver:

Blödt S. Comparative effectiveness research in Chinese Medicine. [Internet] [Thesis]. Freie Universität Berlin; 2017. [cited 2021 Feb 25]. Available from: https://refubium.fu-berlin.de/handle/fub188/10573.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Blödt S. Comparative effectiveness research in Chinese Medicine. [Thesis]. Freie Universität Berlin; 2017. Available from: https://refubium.fu-berlin.de/handle/fub188/10573

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Iowa

29. Weigel, Paula Anne Michel. The comparative effectiveness of chiropractic on function, health, depressive symptoms, and satisfaction with care among medicare beneficiaries.

Degree: PhD, Health Services and Policy, 2014, University of Iowa

URL: https://ir.uiowa.edu/etd/4791

► Musculoskeletal complaints are one of the most common reasons for visits to medical and chiropractic professionals in the United States, and spine-related symptoms in… (more)

▼ Musculoskeletal complaints are one of the most common reasons for visits to medical and chiropractic professionals in the United States, and spine-related symptoms in particular comprise the largest share of these complaints. Spine-related conditions increase as people age, having implications for rising disability and consequent spending by Medicare and Medicaid on increased health services use and long-term services and support. Chiropractic is one type of treatment used by older adults with these types of health problems. Covered by Medicare since 1972, chiropractic spinal manipulation is allowed for the express purpose to arrest the progression of functional decline or restore and possibly improve patient function. No studies, however, have examined whether chiropractic use by Medicare beneficiaries has indeed arrested functional decline, delayed disability, or restored health. The purpose of this dissertation research is to examine the comparative effectiveness of chiropractic use relative to no treatment and alternative medical care on the health and functional trajectories of community-dwelling older adults. I also examine the comparative effect of chiropractic on satisfaction with care. This is accomplished through the use of two longitudinal surveys with representative Medicare populations linked to Medicare provider claims. The first analysis examines the long-term comparative effect of chiropractic relative to no use and alternative care on functional decline, self-rated health decline, and the onset of additional depressive symptoms in a cohort of older Medicare beneficiaries, both with and without back conditions. The second study examines the effect of chiropractic compared to medical only episodes of care on health and functional decline in an older adult population with uncomplicated back conditions over a two-year period. The third and final study examines the comparative effect of chiropractic relative to medical care only on one-year changes in function, self-rated health, and satisfaction with care in a nationally representative age-eligible Medicare population with spine-related musculoskeletal conditions. Study results suggest that chiropractic has a consistently protective effect when compared to routine alternative medical care against decline in function among older adults with spine-related conditions, both over the long-term and the short-term. Chiropractic also has a comparative protective effect against decline in self-rated health in the short-term, but has no differential effect on the onset of depressive symptoms either in the short-term or long-term . Medicare beneficiaries using chiropractic for spine-related health conditions are relatively more satisfied than those using medical care only with the information provided to them about their condition, and with follow-up care provided after the initial visit. This research is the first of its kind to examine the comparative effectiveness of chiropractic relative to other usual sources of care for Medicare… Advisors/Committee Members: Ward, Marcia M., 1950- (supervisor).

Subjects/Keywords: Chiropractic; Comparative effectiveness research; Functional health; Medicare beneficiaries; Satisfaction with care; Self-Rated health; Health Services Administration

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Weigel, P. A. M. (2014). The comparative effectiveness of chiropractic on function, health, depressive symptoms, and satisfaction with care among medicare beneficiaries. (Doctoral Dissertation). University of Iowa. Retrieved from https://ir.uiowa.edu/etd/4791

Chicago Manual of Style (16^th Edition):

Weigel, Paula Anne Michel. “The comparative effectiveness of chiropractic on function, health, depressive symptoms, and satisfaction with care among medicare beneficiaries.” 2014. Doctoral Dissertation, University of Iowa. Accessed February 25, 2021. https://ir.uiowa.edu/etd/4791.

MLA Handbook (7^th Edition):

Weigel, Paula Anne Michel. “The comparative effectiveness of chiropractic on function, health, depressive symptoms, and satisfaction with care among medicare beneficiaries.” 2014. Web. 25 Feb 2021.

Vancouver:

Weigel PAM. The comparative effectiveness of chiropractic on function, health, depressive symptoms, and satisfaction with care among medicare beneficiaries. [Internet] [Doctoral dissertation]. University of Iowa; 2014. [cited 2021 Feb 25]. Available from: https://ir.uiowa.edu/etd/4791.

Council of Science Editors:

Weigel PAM. The comparative effectiveness of chiropractic on function, health, depressive symptoms, and satisfaction with care among medicare beneficiaries. [Doctoral Dissertation]. University of Iowa; 2014. Available from: https://ir.uiowa.edu/etd/4791

University of Houston

30. Yang, Mo 1985-. Comparative Effectiveness of Smoking Cessation Medications among Obese Smokers.

Degree: PhD, Pharmacy Administration, 2013, University of Houston

URL: http://hdl.handle.net/10657/1070

► Objective I: To compare the continuous abstinence rates of FDA-approved smoking cessation medication strategies during a) 3 months, b) 6 months, and b) 12 months… (more)

Subjects/Keywords: Comparative effectiveness; Smoking cessation; Abstinence rate; Obesity; Weight Change; Type 2 Diabetes; Varenicline; Bupropion; Pharmacy management

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Yang, M. 1. (2013). Comparative Effectiveness of Smoking Cessation Medications among Obese Smokers. (Doctoral Dissertation). University of Houston. Retrieved from http://hdl.handle.net/10657/1070

Chicago Manual of Style (16^th Edition):

Yang, Mo 1985-. “Comparative Effectiveness of Smoking Cessation Medications among Obese Smokers.” 2013. Doctoral Dissertation, University of Houston. Accessed February 25, 2021. http://hdl.handle.net/10657/1070.

MLA Handbook (7^th Edition):

Yang, Mo 1985-. “Comparative Effectiveness of Smoking Cessation Medications among Obese Smokers.” 2013. Web. 25 Feb 2021.

Vancouver:

Yang M1. Comparative Effectiveness of Smoking Cessation Medications among Obese Smokers. [Internet] [Doctoral dissertation]. University of Houston; 2013. [cited 2021 Feb 25]. Available from: http://hdl.handle.net/10657/1070.

Council of Science Editors:

Yang M1. Comparative Effectiveness of Smoking Cessation Medications among Obese Smokers. [Doctoral Dissertation]. University of Houston; 2013. Available from: http://hdl.handle.net/10657/1070

Open Access Theses and Dissertations