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1.
Gómez de las Heras, Cristina.
Papel de la colonografía por tomografía computerizada en el carcinoma colorrectal.
Degree: 2014, Universidad de Sevilla
URL: http://hdl.handle.net/11441/24128 
► El cáncer colorrectal (CCR) es una de las neoplasias más frecuentes en los países occidentales, siendo la segunda neoplasia más frecuente en ambos sexos en…
(more)
▼ El cáncer colorrectal (CCR) es una de las neoplasias más frecuentes en los países occidentales, siendo la segunda neoplasia más frecuente en ambos sexos en Andalucía, detrás del cáncer de pulmón en el hombre y de mama en la mujer. A pesar del avance experimentado en los últimos años en relación a su tratamiento, constituye la segunda causa más frecuente de muerte por cáncer. Es, además, la neoplasi maligna más frecuente del aparato digestivo y el riesgo se incrementa a partir de los 50 años. Este hecho, junto con el establecimiento de la secuencia adenoma-carcinoma (el 85-90% de los CCR se origina en un adenoma) y la posterior demostración de que la mayoría de cánceres colorectales y muertes por dicho cáncer se pueden prevenir mediante la protección, es decir, mediante la búsqueda de lesiones cancerosas y precancerosas y su resección endoscópica, justifica que la detección del cáncer colorrectal y sus precursores sea un tema importante dentro de la salud pública. La protección es ideal debido a las diversas características del cáncer colorrectal. En primer lugar, es común y grave (fatal, si no se detecta a tiempo o se deja de tratar). En segundo lugar, va precedido de una lesión de fácil identificación y lento crecimiento, el adenoma avanzado, cuya extirpación impide que se convierta en cáncer. En tercer lugar, se cree que tras su desarrollo, el cáncer colorectal evoluciona de manera relativamente lenta desde etapas fácilmente curables con cirugía hasta etapas donde ello es imposible. La colonoscopia convencional es la técnica de elección para el diagnóstico de las neoplasias colorrectales, dado que además de ver más lesiones colorrectales, permite obtener biopsias y resecar lesiones precancerosas. Últimamente se ha desarrollado la colonograf{|
Advisors/Committee Members: Sabaté Díaz, Juan (advisor), Universidad de Sevilla. Departamento de Farmacología, Pediatría y Radiología (affiliation).
Subjects/Keywords: Colon
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APA (6th Edition):
Gómez de las Heras, C. (2014). Papel de la colonografía por tomografía computerizada en el carcinoma colorrectal. (Thesis). Universidad de Sevilla. Retrieved from http://hdl.handle.net/11441/24128
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Gómez de las Heras, Cristina. “Papel de la colonografía por tomografía computerizada en el carcinoma colorrectal.” 2014. Thesis, Universidad de Sevilla. Accessed March 07, 2021.
http://hdl.handle.net/11441/24128.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Gómez de las Heras, Cristina. “Papel de la colonografía por tomografía computerizada en el carcinoma colorrectal.” 2014. Web. 07 Mar 2021.
Vancouver:
Gómez de las Heras C. Papel de la colonografía por tomografía computerizada en el carcinoma colorrectal. [Internet] [Thesis]. Universidad de Sevilla; 2014. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/11441/24128.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Gómez de las Heras C. Papel de la colonografía por tomografía computerizada en el carcinoma colorrectal. [Thesis]. Universidad de Sevilla; 2014. Available from: http://hdl.handle.net/11441/24128
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
2.
Armstrong, Cameron Michelle.
The Protective Effects of Estradiol on Sporadic and Inflammation-associated Colon Cancer.
Degree: 2013, Texas Digital Library
URL: http://hdl.handle.net/1969;
http://hdl.handle.net/2249.1/66776
► Epidemiological studies suggest pre-menopausal women have a reduced risk for sporadic and inflammation-associated colon cancer compared to post-menopausal women and men. The studies presented herein…
(more)
▼ Epidemiological studies suggest pre-menopausal women have a reduced risk for sporadic and inflammation-associated
colon cancer compared to post-menopausal women and men. The studies presented herein aim to determine the protective mechanisms of estradiol (E2) during sporadic and inflammation-associated colonic carcinogenesis.
When investigating the role of E2 and fish oil at the earliest stage of sporadic
colon cancer development, E2 had no effect on DNA adduct formation while dietary fish oil significantly reduced DNA adduct formation. Contrarily, E2 significantly induced apoptosis of damaged colonocytes while fish oil was not protective.
In an in vivo model of inflammation-associated
colon carcinogenesis with E2 administered following induction of DNA damage and initiation of inflammation, E2 treatment was associated with decreased
colon tumor size and number in wild type (WT) but not estrogen receptor (ER) ?? knockout (ER??KO) mice. Interestingly, apoptosis was reduced and proliferation increased by E2 in these tumors in WT mice. This may be due to the altered ER expression in these tissues as the tumors developed, with ER????expression decreasing concomitantly with ER?? expression increasing.
Contrary to the protective effect of E2 on inflammation-associated
colon tumor formation, which was dependent on ER??, during acute inflammation in the
colon E2 was protective against inflammation in both WT and ER??KO mice and injury in ER??KO mice. The protection against inflammation is likely due to the reduction of pro-inflammatory cytokine expression by E2. Apoptosis and proliferation were decreased and increased in the proximal and distal
colon respectively in ER??KO mice.
In vitro studies further elucidated the roles of ER?? and ER?? in colonocytes. E2 and ER??, but not ER??, specific agonists reduced cell number and induce apoptosis in nonmalignant colonocytes. This effect was lost in the presence of mutated p53. In ER?? overexpressed nonmalignant colonocytes, E2 had no effect on cell number while ER?? agonist and ER?? agonists decreased and increased cell number respectively.
These studies suggest that E2 is protective in the
colon and ER?? is required for protection against carcinogenesis but not protection against inflammation. Additionally, the protection against
colon carcinogenesis is likely p53 mediated.
Advisors/Committee Members: Allred, Clinton D (advisor).
Subjects/Keywords: colon cancer
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APA (6th Edition):
Armstrong, C. M. (2013). The Protective Effects of Estradiol on Sporadic and Inflammation-associated Colon Cancer. (Thesis). Texas Digital Library. Retrieved from http://hdl.handle.net/1969; http://hdl.handle.net/2249.1/66776
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Armstrong, Cameron Michelle. “The Protective Effects of Estradiol on Sporadic and Inflammation-associated Colon Cancer.” 2013. Thesis, Texas Digital Library. Accessed March 07, 2021.
http://hdl.handle.net/1969; http://hdl.handle.net/2249.1/66776.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Armstrong, Cameron Michelle. “The Protective Effects of Estradiol on Sporadic and Inflammation-associated Colon Cancer.” 2013. Web. 07 Mar 2021.
Vancouver:
Armstrong CM. The Protective Effects of Estradiol on Sporadic and Inflammation-associated Colon Cancer. [Internet] [Thesis]. Texas Digital Library; 2013. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/1969; http://hdl.handle.net/2249.1/66776.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Armstrong CM. The Protective Effects of Estradiol on Sporadic and Inflammation-associated Colon Cancer. [Thesis]. Texas Digital Library; 2013. Available from: http://hdl.handle.net/1969; http://hdl.handle.net/2249.1/66776
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
3.
Routy, Bertrand.
Contribution of Gut Microbiota on Systemic Response to Anticancer Immonumodulatory Agents : Rôle du microbiote intestinal dans l'éfficacité et la toxicité des thérapies anti-tumorales immunomodulatrice.
Degree: Docteur es, Aspects moléculaires et cellulaires de la biologie, 2017, Université Paris-Saclay (ComUE)
URL: http://www.theses.fr/2017SACLS398
► Les anticorps bloquant les rétrocontrôles inhibiteurs du système immunitaire (ICB) ont révolutionné la prise en charge des patients atteints de certains cancers. Les ICB bloquent…
(more)
▼ Les anticorps bloquant les rétrocontrôles inhibiteurs du système immunitaire (ICB) ont révolutionné la prise en charge des patients atteints de certains cancers. Les ICB bloquent l’axe cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) ou programmed cell death protein 1/PD-L1-PD-L2 et permettent une réactivation des cellules T stimulant l’immunité anti-tumorale. Toutefois, malgré cette avancée plus de 70 % des patients finiront par progresser et ces traitements peuvent entrainer des toxicités de type auto-immunes sévères. Il est donc fondamental d’identifier des biomarqueurs prédictifs de la réponse clinique et ainsi développer une nouvelle stratégie thérapeutique efficace pour augmenter l’index thérapeutique des ICB. Plusieurs groupes ont participé à décrire le lien étroit entre le microbiote intestinal et la réponse à la chimiothérapie (cyclophosphamide), à la greffe allogénique ainsi qu’aux les thérapies immunomodulatrices (anti-CTLA4 and PD1 Abs). Mon travail de thèse vient à la suite de ces travaux princeps et a permis de montrer que la composition du microbiote intestinal est en partie responsable de l’activité anti-tumorale des ICB dans plusieurs cancers. L’analyse de 249 patients atteints d’un cancer métastatique du poumon, du rein et cancer urothelial traités par l’anti-PD-1 ou l’anti-PD-L1 les antibiotiques (ATB) diminuaient la survie sans progression (PFS) de 3.5 vs 4.1 mois (p=0.017) et la survie globale de 11.5 vs 20.6 mois (p<0.001) par rapport aux patients n’ayant pas pris d’ATB avant de débuter les ICB. Nous avons par la suite analysé par métagénomique les selles de 153 patients atteints d’un cancer du poumon et du rein traités par l’anti-PD-1. Les résultats ont montré que Akkermmansia muciniphila est plus abondante chez les patients ayant une meilleure réponse clinique et une meilleure PFS. De plus, nous avons démontré que la présence d’une réponse mémoire spécifique des cellules CD4+ ou CD8+ envers A. muciniphila est associée à une plus longue PFS. Par la suite, des transplantations de microbiote fécal (FMT) avec les selles de ces patients chez des souris axéniques ou traitées par ATB montrent que les selles des répondeurs à l’anti-PD-1 entrainent une forte réponse immunitaire anti-tumorale post anti-PD-1 comparé aux selles de non-répondeurs. De plus, un gavage oral avec A. muciniphila après la FMT avec des selles de non-répondeurs restaure une forte réponse immunitaire post anti-PD-1 via la production d’IL-12 par les cellules dendritiques entrainant l’augmentation du recrutement des cellules T CD4+CXCR3+CCR9+ du ganglion mésentérique vers le site tumoral et une augmentation du ratio CD4/Treg. L’ensemble de ces résultats suggèrent que la découverte de bactérie immunogène capable de prédire le bénéfice clinique des ICB permettra de développer une stratégie thérapeutique efficace afin d’augmenter la survie des patients atteints de cancer.Mots clés : ICB, anti-PD-1, anti-PDL-1, cancer du poumon, cancer du rein, microbiote intestinal
In oncology, a novel therapeutic era based on immune checkpoint…
Advisors/Committee Members: Zitvogel, Laurence (thesis director).
Subjects/Keywords: Immunologie; Microbiote; Colon; Immunology; Microbiota; Colon
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APA ·
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APA (6th Edition):
Routy, B. (2017). Contribution of Gut Microbiota on Systemic Response to Anticancer Immonumodulatory Agents : Rôle du microbiote intestinal dans l'éfficacité et la toxicité des thérapies anti-tumorales immunomodulatrice. (Doctoral Dissertation). Université Paris-Saclay (ComUE). Retrieved from http://www.theses.fr/2017SACLS398
Chicago Manual of Style (16th Edition):
Routy, Bertrand. “Contribution of Gut Microbiota on Systemic Response to Anticancer Immonumodulatory Agents : Rôle du microbiote intestinal dans l'éfficacité et la toxicité des thérapies anti-tumorales immunomodulatrice.” 2017. Doctoral Dissertation, Université Paris-Saclay (ComUE). Accessed March 07, 2021.
http://www.theses.fr/2017SACLS398.
MLA Handbook (7th Edition):
Routy, Bertrand. “Contribution of Gut Microbiota on Systemic Response to Anticancer Immonumodulatory Agents : Rôle du microbiote intestinal dans l'éfficacité et la toxicité des thérapies anti-tumorales immunomodulatrice.” 2017. Web. 07 Mar 2021.
Vancouver:
Routy B. Contribution of Gut Microbiota on Systemic Response to Anticancer Immonumodulatory Agents : Rôle du microbiote intestinal dans l'éfficacité et la toxicité des thérapies anti-tumorales immunomodulatrice. [Internet] [Doctoral dissertation]. Université Paris-Saclay (ComUE); 2017. [cited 2021 Mar 07].
Available from: http://www.theses.fr/2017SACLS398.
Council of Science Editors:
Routy B. Contribution of Gut Microbiota on Systemic Response to Anticancer Immonumodulatory Agents : Rôle du microbiote intestinal dans l'éfficacité et la toxicité des thérapies anti-tumorales immunomodulatrice. [Doctoral Dissertation]. Université Paris-Saclay (ComUE); 2017. Available from: http://www.theses.fr/2017SACLS398
4.
Fabrizi, Eros.
Identification of novel therapeutic targets for colon adenocarcinoma.
Degree: 2011, Università degli Studi di Catania
URL: http://hdl.handle.net/10761/95
► Colorectal cancer (CRC) is the third most common form of cancer in the Western world. Despite the emergence of new targeted agents and the use…
(more)
▼ Colorectal cancer (CRC) is the third most common form of cancer in the Western world.
Despite the emergence of new targeted agents and the use of various therapeutic
combinations, none of the treatment options available is curative in patients with advanced
cancer. A growing body of evidence is increasingly supporting the idea that malignancies
originate from a small fraction of cancer cells, called Cancer Stem Cells (CSC), that show
self-renewal and pluripotency and are capable of initiating and sustaining tumor growth.
Several studies have shown that, with respect to the bulk of tumor cells, CSC posses a
higher degree of resistance to chemotherapy and radiotherapy that could explain the
inefficacy of current therapies. The ability to isolate and study these tumor cells provided a
powerful tool for the investigation of drug-and radio-resistance mechanisms thus paving
the way for the development of novel targeted therapies aimed at the tumor complete
eradication.
The aim of this PhD thesis was to use CSC lines, derived from CRC specimens, to
individuate new potential molecular targets for the development of novel therapies. To this
end four colon-CSC lines were subjected to phosphoproteomic analysis by RPPA (Reverse
Phase Protein Array) technology. Through this analysis phosphorylation levels of various
protein kinases and their substrates were evaluated in order to create an activation map of
the main colon-CSC proliferation and cell survival pathways. In parallel colon-CSC lines
have been screened in vitro to the action of 80 commercially available protein-kinase
inhibitors. This screening has revealed a partial correlation between in vitro sensitivity and
phosphoproteomic analysis, but in this study, was not possible to identify predictive factors
to infer colon-CSC sensitivity to specific kinase inhibitors. Colon-CSC was sensitive to the
inhibition of protein kinase C (PKC), known regulator of cell proliferation and survival.
Among PKC inhibitors, the most interesting was the UCN-01, a staurosporine derivative
that can also inhibit PDK1 and Chk1. This compound has been already used in clinical
trials as antineoplastic agent in combination with conventional chemotherapy. The in vitro
treatment of colon-CSC with UCN-01 has demonstrated its ability to enhance the
irinotecan cytotoxicity by increasing the apoptotic response. The combined action of
UCN-01 and irinotecan caused a marked reduction in the levels of antiapoptotic proteins
such as Bcl-XL and Mcl-1 and the activation of caspase 3.
The in vivo administration of UCN-01/irinotecan combination, in a mouse model of
subcutaneous xenograft, confirmed the observations obtained in vitro, leading to a
significant reduction in tumor growth compared to the single treatments. UCN-01 has also shown efficacy in the inhibition of Chk1, as demonstrated by the reduction of the
phosphorylation of its target protein cdc25. Inhibition of Chk1, an important regulator of
cell cycle, in combination with chemotherapy, could help in…
Subjects/Keywords: Colon cancer; Colon cancer stem cells
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APA (6th Edition):
Fabrizi, E. (2011). Identification of novel therapeutic targets for colon adenocarcinoma. (Thesis). Università degli Studi di Catania. Retrieved from http://hdl.handle.net/10761/95
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Fabrizi, Eros. “Identification of novel therapeutic targets for colon adenocarcinoma.” 2011. Thesis, Università degli Studi di Catania. Accessed March 07, 2021.
http://hdl.handle.net/10761/95.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Fabrizi, Eros. “Identification of novel therapeutic targets for colon adenocarcinoma.” 2011. Web. 07 Mar 2021.
Vancouver:
Fabrizi E. Identification of novel therapeutic targets for colon adenocarcinoma. [Internet] [Thesis]. Università degli Studi di Catania; 2011. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/10761/95.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Fabrizi E. Identification of novel therapeutic targets for colon adenocarcinoma. [Thesis]. Università degli Studi di Catania; 2011. Available from: http://hdl.handle.net/10761/95
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
5.
Arteaga Hernández, Allan Fernando.
Manejo quirúrgico del cáncer de colón en el hospital Nacional dos de mayo.
Degree: 2013, National University of San Marcos
URL: http://hdl.handle.net/20.500.12672/3962
► En el Perú, según estadísticas del año 2011, el cáncer constituye la segunda causa de muerte, sólo después de las enfermedades cardiovasculares. Asimismo, en nuestra…
(more)
▼ En el Perú, según estadísticas del año 2011, el cáncer constituye la segunda causa de muerte, sólo después de las enfermedades cardiovasculares. Asimismo, en nuestra realidad hospitalaria, el cáncer de colon constituye un problema en aumento, cuyo manejo quirúrgico es de vital importancia, sobretodo en el tratamiento con intención curativa. Afecta con mayor frecuencia a adultos mayores, a hombres y mujeres; pero, cada día se detectan más casos en gente más joven. De ahí la importancia de un adecuado manejo quirúrgico de estos pacientes, con la finalidad de aumentar la sobrevida y en lo posible, curar.
El tenor del presente trabajo de investigación fue evaluar el manejo quirúrgico de los pacientes con diagnóstico de cáncer de colon, a fin de realizar recomendaciones al respecto en mejora de la atención de los pacientes que a diario acuden a nuestro hospital en busca de atención de calidad.
Subjects/Keywords: Colon (Anatomía) - Cirugía; Colon (Anatomía) - Cáncer - Diagnóstico
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APA (6th Edition):
Arteaga Hernández, A. F. (2013). Manejo quirúrgico del cáncer de colón en el hospital Nacional dos de mayo. (Thesis). National University of San Marcos. Retrieved from http://hdl.handle.net/20.500.12672/3962
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Arteaga Hernández, Allan Fernando. “Manejo quirúrgico del cáncer de colón en el hospital Nacional dos de mayo.” 2013. Thesis, National University of San Marcos. Accessed March 07, 2021.
http://hdl.handle.net/20.500.12672/3962.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Arteaga Hernández, Allan Fernando. “Manejo quirúrgico del cáncer de colón en el hospital Nacional dos de mayo.” 2013. Web. 07 Mar 2021.
Vancouver:
Arteaga Hernández AF. Manejo quirúrgico del cáncer de colón en el hospital Nacional dos de mayo. [Internet] [Thesis]. National University of San Marcos; 2013. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/20.500.12672/3962.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Arteaga Hernández AF. Manejo quirúrgico del cáncer de colón en el hospital Nacional dos de mayo. [Thesis]. National University of San Marcos; 2013. Available from: http://hdl.handle.net/20.500.12672/3962
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
6.
Massalou, Damien.
Comportement mécanique du colon humain en situation traumatique : Mechanical behavior of the human colon under trauma.
Degree: Docteur es, Sciences du Mouvement Humain, 2018, Aix Marseille Université
URL: http://www.theses.fr/2018AIXM0458
► Introduction. L’objectif de cette étude est de déterminer la réponse mécanique du colon en traction uniaxiale jusqu’à la rupture et quels sont les facteurs la…
(more)
▼ Introduction. L’objectif de cette étude est de déterminer la réponse mécanique du colon en traction uniaxiale jusqu’à la rupture et quels sont les facteurs la modifiant.Matériel et méthodes Nous avons réalisé des essais dynamiques uniaxiaux de spécimens coliques humains. Trois vitesses de sollicitation étaient testées : dynamique (1m/s), intermédiaire (10cm/s) et quasi-statique (1cm/s).Résultats Vingt-huit colons humains réfrigérés ont été testés avec un total de 344 spécimens. Le colon présente un comportement mécanique bicouche. Le comportement mécanique est variable en fonction de la localisation sur le cadre colique. Le sexe représente également un facteur responsable d’une modification de la réponse mécanique du colon. La durée de conservation des corps et le tænia coli ne représentaient pas un facteur influençant le comportement mécanique dynamique du colon.La réponse mécanique enregistrée est différente en fonction de l’orientation de la sollicitation : les niveaux de contrainte et de déformation étaient plus élevés sous sollicitation transversale.La vitesse de sollicitation modifie la réponse mécanique enregistrée avec des niveaux de rupture plus faibles sous sollicitation dynamique.Le type de conservation modifie la déformation et la force nécessaires pour obtenir des lésions coliques.ConclusionLe colon se comporte comme un matériau viscoélastique ductile et bicouche. Son comportement mécanique est dépendant de la localisation sur le cadre colique, du sexe, des méthodes de conservation et des vitesses de sollicitation. Cette étude permettra l’intégration de données biomécaniques dans des modèles de traumatologie virtuelle ou de simulation chirurgicale.
IntroductionThe objective of this study is to determine the mechanical response of the colon in uniaxial traction until rupture and what are the modifying factors.Material and methodsWe performed uniaxial dynamic tests of human colonic specimens. Three loading speeds were tested: dynamic (1m/s), intermediate (10cm/s) and static (1cm/s).ResultsTwenty-eight refrigerated human colons were tested with a total of 344 specimens. The colon exhibits a bi-layered mechanical behavior.The mechanical behavior is variable according to the localization on the colonic frame with a more elastic behavior of the right colon and the sigmoid colon. Gender is also a factor responsible for a change in the mechanical response of the colon. The shelf life of the body and tænia coli were not a factor influencing the mechanical behavior of the colon under dynamic solicitation.The recorded mechanical response is different depending on the orientation of the stress: the stress and strain levels were higher under circumferential stress.The loading speed changes the recorded mechanical response. The colon is more elastic in a quasi-static situation and has lower levels of rupture under dynamic stress. Under dynamic loading, the type of preservation does not modify the stiffness of the tissue but modifies the stress and strain necessary to obtain colonic lesions.ConclusionThe colon…
Advisors/Committee Members: Masson, Catherine (thesis director), Bège, Thierry (thesis director).
Subjects/Keywords: Traumatisme; Colon; Biomécanique; Trauma; Colon; Biomechanics; 612
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APA ·
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Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Massalou, D. (2018). Comportement mécanique du colon humain en situation traumatique : Mechanical behavior of the human colon under trauma. (Doctoral Dissertation). Aix Marseille Université. Retrieved from http://www.theses.fr/2018AIXM0458
Chicago Manual of Style (16th Edition):
Massalou, Damien. “Comportement mécanique du colon humain en situation traumatique : Mechanical behavior of the human colon under trauma.” 2018. Doctoral Dissertation, Aix Marseille Université. Accessed March 07, 2021.
http://www.theses.fr/2018AIXM0458.
MLA Handbook (7th Edition):
Massalou, Damien. “Comportement mécanique du colon humain en situation traumatique : Mechanical behavior of the human colon under trauma.” 2018. Web. 07 Mar 2021.
Vancouver:
Massalou D. Comportement mécanique du colon humain en situation traumatique : Mechanical behavior of the human colon under trauma. [Internet] [Doctoral dissertation]. Aix Marseille Université 2018. [cited 2021 Mar 07].
Available from: http://www.theses.fr/2018AIXM0458.
Council of Science Editors:
Massalou D. Comportement mécanique du colon humain en situation traumatique : Mechanical behavior of the human colon under trauma. [Doctoral Dissertation]. Aix Marseille Université 2018. Available from: http://www.theses.fr/2018AIXM0458
University of Utah
7.
Andersen, Melissa.
Role of MSH6 mutations in North American patients receiving clinical genetic testing for hereditary nonpolyposis colorectal cancer;.
Degree: MS;, Pathology;, 2007, University of Utah
URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1314/rec/1163
► The relationship of fibrinolytic activity produced by baby hamster kidney (BHK-21) cells to surface properties and growth of the cells has been studied. Hydrolysis of…
(more)
▼ The relationship of fibrinolytic activity produced by baby hamster kidney (BHK-21) cells to surface properties and growth of the cells has been studied. Hydrolysis of fibrin clots and casein was used to detect cellular protease activity. Cloned, high passage sublines of the BHK-21/C13 cell line were found to produce increased fibrinolysis when compared to low passage BHK-21/C13 cells (C13). Low passage C13 cells were also found to produce an inhibitor of the cellular fibrinolysin. This inhibitory activity was detected when low and high protease-producing cell lines were co-cultivated and could be removed from the C13 cells by trypsin treatment. Inhibitor could again be detected in C13 cell cultures after 6-8.5 hours incubation at 37°C following typsinization. This substance was not detected in supernatant fluids from growing C13 cells and its production was inhibited by incubation of cells at 4°C. All high protease-producing cultures formed colonies in agar suspension, exhibited quantitative increases in agglutinability by concanavalin A (Con A) when compared to low passage cell cultures and grew faster as judged by transfer behavior of cells and increased rates of accumulation of cells in metaphase when grown in the presence of mitotic inhibitor. Low protease-producing C13 cells and sublines low in protease activity isolated from high passage cultures did not grow in agar suspension, exhibited slower growth rates and decreased agglutinability by Con A. Low protease-producing C13 cells could be stimulated to produce increase amounts of fibrinolytic activity with accompanying changes in surface properties characteristic of transformed cells by addition of purines such as hypoxanthine or adenosine to culture media. The effect was reversed by deletion of the purines. Growth of C13 cell in agar suspension did not occur with purine supplementation alone. With the addition of hypoxanthine and thymidine or adenosine and thymidine or adenosine and thymidine, C13 cells formed colonies in agar suspension which were similar to those formed by high protease-producing cell lines. Fibrinolytic activity could be detected from the colonies formed by C13 cells in agar suspension. Treatment of C13 cells suspended in agar with trypsin or fibrinolytically active culture fluids from high protease-producing cells did not result in the multiplication of the cells in agar. Temperature sensitive BHK-21 cells were isolated which were defective for cytokinesis but not karyokinesis. At 39-40°C these cells became enlarged and multinucleated. The defect did not appear to be associated with the cellular fibrinolysin because protease activity could be detected at the permissive and non-permissive temperatures. Growth of temperature sensitive cells in agar suspension did not occur at 39-40°C but cell enlargement, vacillation and lysis were observed in a large portion of the cell population. The data demonstrate that growth in agar suspension, increased Con A agglutinability and increased growth rates are positively associated in some way with the…
Subjects/Keywords: Colon Cancer; Genetics
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APA (6th Edition):
Andersen, M. (2007). Role of MSH6 mutations in North American patients receiving clinical genetic testing for hereditary nonpolyposis colorectal cancer;. (Masters Thesis). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1314/rec/1163
Chicago Manual of Style (16th Edition):
Andersen, Melissa. “Role of MSH6 mutations in North American patients receiving clinical genetic testing for hereditary nonpolyposis colorectal cancer;.” 2007. Masters Thesis, University of Utah. Accessed March 07, 2021.
http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1314/rec/1163.
MLA Handbook (7th Edition):
Andersen, Melissa. “Role of MSH6 mutations in North American patients receiving clinical genetic testing for hereditary nonpolyposis colorectal cancer;.” 2007. Web. 07 Mar 2021.
Vancouver:
Andersen M. Role of MSH6 mutations in North American patients receiving clinical genetic testing for hereditary nonpolyposis colorectal cancer;. [Internet] [Masters thesis]. University of Utah; 2007. [cited 2021 Mar 07].
Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1314/rec/1163.
Council of Science Editors:
Andersen M. Role of MSH6 mutations in North American patients receiving clinical genetic testing for hereditary nonpolyposis colorectal cancer;. [Masters Thesis]. University of Utah; 2007. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1314/rec/1163
Universidad de Valladolid
8.
Forero Torres, Augusto Alexander.
Características epidemiológicas de la enfermedad diverticular del colon y de la diverticulitis aguda en Castilla y León. Aspectos sobre el tratamiento médico y quirúrgico.
Degree: 2016, Universidad de Valladolid
URL: http://uvadoc.uva.es/handle/10324/16848
► La enfermedad diverticular del colon es una de las enfermedades más prevalentes que afectan a la población occidental y por ende a la Comunidad Autónoma…
(more)
▼ La enfermedad diverticular del colon es una de las enfermedades más prevalentes que afectan a la población occidental y por ende a la Comunidad Autónoma de Castilla y León. Es una patología relacionada con nuestro estilo de vida, con un aparente incremento estacional en los meses de verano y un amplio espectro de presentaciones clínicas con una tasa de mortalidad en pacientes intervenidos de urgencia que alcanza el 12% al 36%; genera estancias hospitalarias prolongadas y gastos no solo sanitarios sino de incapacidad, producidos por la presencia de un estoma.
Se trata de un estudio observacional y descriptivo en la población mayor de edad hospitalizada en centros públicos de Sanidad de Castilla y León (SACYL) entre el 01 de enero de 2.001 y el 31 de diciembre de 2.013. La población de estudio está constituida por 12.689 casos, dados de alta con un diagnostico primario o secundario de diverticulitis y/o diverticulosis de colon. La base de datos utilizada fue el conjunto mínimo básico de datos (CMBD) y la clasificación se realizó teniendo en cuenta la clasificación internacional de enfermedades (CIE-9-MC) y los Grupos Relacionados por el Diagnóstico.
Los resultados obtenidos nos permitieron llegar, entre otras, a las siguientes conclusiones: La hospitalización por enfermedad diverticular en Castilla y León presenta una tasa de 4,5 por 100.000 habitantes con un aumento progresivo en el periodo estudiado. La mortalidad global fue del 2,3% manteniéndose estable a lo largo del tiempo estudiado. Existe un incremento global de la enfermedad diverticular del colon, con un descenso de la diverticulitis grave, y un aumento de la diverticulitis leve. No encontramos la existencia de ritmo circanual. El tratamiento médico es 7 veces más frecuente que el quirúrgico en el total de altas de esta enfermedad. Encontramos un mayor porcentaje global de cirugías en los menores de 50 años. El tratamiento quirúrgico se asoció a las variables: edad, ingreso programado, ingresar tres o más veces e ingresar en un hospital general y de referencia. Existe una disminución global de la estancia, siendo el tratamiento quirúrgico el que genera una estancia hospitalaria más prolongada. La realización de una colostomía está relacionada con la edad e ingresar en dos o más ocasiones. Existe una tendencia ascendente en la realización de abordaje laparoscópico. Los ingresos que recibieron tratamiento quirúrgico, presentaron una mayor complejidad que los que recibieron tratamiento médico. Existe un descenso en la mortalidad de los pacientes quirúrgicos, siendo menor en el abordaje laparoscópico. La mortalidad se asoció a las variables: edad, realización de una intervención sobre el colon y realización de colostomía.
Subjects/Keywords: Colon (Anatomía) - Cirugía
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APA (6th Edition):
Forero Torres, A. A. (2016). Características epidemiológicas de la enfermedad diverticular del colon y de la diverticulitis aguda en Castilla y León. Aspectos sobre el tratamiento médico y quirúrgico. (Thesis). Universidad de Valladolid. Retrieved from http://uvadoc.uva.es/handle/10324/16848
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Forero Torres, Augusto Alexander. “Características epidemiológicas de la enfermedad diverticular del colon y de la diverticulitis aguda en Castilla y León. Aspectos sobre el tratamiento médico y quirúrgico.” 2016. Thesis, Universidad de Valladolid. Accessed March 07, 2021.
http://uvadoc.uva.es/handle/10324/16848.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Forero Torres, Augusto Alexander. “Características epidemiológicas de la enfermedad diverticular del colon y de la diverticulitis aguda en Castilla y León. Aspectos sobre el tratamiento médico y quirúrgico.” 2016. Web. 07 Mar 2021.
Vancouver:
Forero Torres AA. Características epidemiológicas de la enfermedad diverticular del colon y de la diverticulitis aguda en Castilla y León. Aspectos sobre el tratamiento médico y quirúrgico. [Internet] [Thesis]. Universidad de Valladolid; 2016. [cited 2021 Mar 07].
Available from: http://uvadoc.uva.es/handle/10324/16848.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Forero Torres AA. Características epidemiológicas de la enfermedad diverticular del colon y de la diverticulitis aguda en Castilla y León. Aspectos sobre el tratamiento médico y quirúrgico. [Thesis]. Universidad de Valladolid; 2016. Available from: http://uvadoc.uva.es/handle/10324/16848
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Universidad de Valladolid
9.
Moreno Racionero, Francisca.
Importancia de la inmunidad perioperatoria en el diagnóstico de la infección intraabdominal tras la cirugía oncológica de colon.
Degree: 2017, Universidad de Valladolid
URL: http://uvadoc.uva.es/handle/10324/28656
► La fuga anastomótica, después de una colectomía, es una de las complicaciones más importantes en cirugía colorrectal, siendo el porcentaje de mortalidad un 10 %…
(more)
▼ La fuga anastomótica, después de una colectomía, es una de las complicaciones más importantes en cirugía colorrectal, siendo el porcentaje de mortalidad un 10 % aproximadamente, aunque en algunas series se constata una tasa de incidencia y mortalidad hasta del 30%. Supone una importante carga económica en cualquier sistema de salud; el coste sanitario directo y anual solamente en Reino Unido es de 1.4-4.4 millones de €, mientras que en Estados Unidos es de 18.700 € por paciente.
Encontrar un marcador biológico capaz de detectar precozmente la fuga anastomótica y más actualmente, con la implantación de los programas de rehabilitación multimodal en la cirugía colorrectal, es necesario.
El objetivo de la investigación es determinar la utilidad de algún marcador bioquímico, e inmunocitológico como predictor de riesgo de infección intraabdominal en una cohorte de pacientes sometidos a una intervención quirúrgica programada por cáncer de colon.
Subjects/Keywords: Colon-Cáncer-Cirugía
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APA (6th Edition):
Moreno Racionero, F. (2017). Importancia de la inmunidad perioperatoria en el diagnóstico de la infección intraabdominal tras la cirugía oncológica de colon. (Thesis). Universidad de Valladolid. Retrieved from http://uvadoc.uva.es/handle/10324/28656
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Moreno Racionero, Francisca. “Importancia de la inmunidad perioperatoria en el diagnóstico de la infección intraabdominal tras la cirugía oncológica de colon.” 2017. Thesis, Universidad de Valladolid. Accessed March 07, 2021.
http://uvadoc.uva.es/handle/10324/28656.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Moreno Racionero, Francisca. “Importancia de la inmunidad perioperatoria en el diagnóstico de la infección intraabdominal tras la cirugía oncológica de colon.” 2017. Web. 07 Mar 2021.
Vancouver:
Moreno Racionero F. Importancia de la inmunidad perioperatoria en el diagnóstico de la infección intraabdominal tras la cirugía oncológica de colon. [Internet] [Thesis]. Universidad de Valladolid; 2017. [cited 2021 Mar 07].
Available from: http://uvadoc.uva.es/handle/10324/28656.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Moreno Racionero F. Importancia de la inmunidad perioperatoria en el diagnóstico de la infección intraabdominal tras la cirugía oncológica de colon. [Thesis]. Universidad de Valladolid; 2017. Available from: http://uvadoc.uva.es/handle/10324/28656
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Toronto
10.
Lakoff, Alanna.
Folate Absorption across the Colon: Caplet Study.
Degree: 2010, University of Toronto
URL: http://hdl.handle.net/1807/30137
► The purpose of this study was to determine the absorption of [13C]5-formyltetrahydrofolic acid across the human colon with an intact microflora. Bioavailability was determined after…
(more)
▼ The purpose of this study was to determine the absorption of [13C]5-formyltetrahydrofolic acid across the human colon with an intact microflora. Bioavailability was determined after administration of a pH-dependent acrylic co-polymer coated barium sulphate caplet containing 855 nmol and measuring the plasma appearance of [13C5]5-methyltetrahydrofolic acid compared to an intravenous injection of the same compound (214 nmol). Blood samples serially collected after both test doses were analyzed by microbiological assay and tandem mass spectrometry to determine total folates and ratio of labeled to unlabeled folates, respectively. Caplet disintegration in the colon was quantitatively assessed by fluoroscopic imaging for six of nine subjects. The plasma [13C5]5-methyltetrahydrofolic acid appearance rate was 4 + 0.9 nmol/h (intravenous) and 0.35 + 0.02 nmol/h (caplet). Mean apparent absorption across the colon was 35%. These findings suggest that physiological doses of natural folate are absorbed across the human colon in the presence of an undisturbed microbiota.
MAST
Advisors/Committee Members: O'Connor, Deborah Louise, Nutritional Sciences.
Subjects/Keywords: folate; caplet; colon
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APA (6th Edition):
Lakoff, A. (2010). Folate Absorption across the Colon: Caplet Study. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/30137
Chicago Manual of Style (16th Edition):
Lakoff, Alanna. “Folate Absorption across the Colon: Caplet Study.” 2010. Masters Thesis, University of Toronto. Accessed March 07, 2021.
http://hdl.handle.net/1807/30137.
MLA Handbook (7th Edition):
Lakoff, Alanna. “Folate Absorption across the Colon: Caplet Study.” 2010. Web. 07 Mar 2021.
Vancouver:
Lakoff A. Folate Absorption across the Colon: Caplet Study. [Internet] [Masters thesis]. University of Toronto; 2010. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/1807/30137.
Council of Science Editors:
Lakoff A. Folate Absorption across the Colon: Caplet Study. [Masters Thesis]. University of Toronto; 2010. Available from: http://hdl.handle.net/1807/30137
University of Oxford
11.
Gordon-Weeks, Alex.
Identification of recruited myeloid cells important for the development of hepatic metastasis.
Degree: PhD, 2015, University of Oxford
URL: http://ora.ox.ac.uk/objects/uuid:fc35cc76-0a69-4b1f-b5b7-4be94df1cd36
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.711725
► Hepatic metastases are a frequent cause of mortality in colon cancer patients. Many patients with hepatic metastasis have large tumour burden, signaling the need for…
(more)
▼ Hepatic metastases are a frequent cause of mortality in colon cancer patients. Many patients with hepatic metastasis have large tumour burden, signaling the need for therapies capable of down-staging metastatic disease. Research evidence indicates that immune cells promote the metastasis of various primary cancers. We wish to determine whether immune cells play a role in the promotion of hepatic colon cancer metastasis. Using the well-characterised method of intrasplenic tumour cell injection, we developed hepatic metastases in both immunocompetent and immunoincompetent mice using a range of murine and human cancer cell lines. We analysed the immune cell infiltrates associated with hepatic metastases using flow cytometry and identified chemokines responsible for their recruitment using targeted protein arrays. The effect of immune cell depletion or inhibition of immune cell recruitment was determined using various in-vivo imaging techniques. Hepatic metastases developed using the murine colon cancer cell line MC38 were associated with CD11b+/Gr1mid/CCR2+ monocytes, the recruitment of which was delayed by inhibition of tumour-derived CCL2. In contrast, human HT29, HCT-116 and LoVo hepatic metastases in SCID mice were associated with infiltrates of CD45+/CXCR2+ neutrophils recruited in response to tumour-derived Macrophage Inhibitory Factor (MIF). Depletion of Gr1mid cells in CD11b-DTR transgenic mice delayed MC38 metastasis development, whilst neutrophil depletion using anti-Ly6G antibodies significantly inhibited the growth of HT29, HCT-116 and LoVo hepatic metastases. The neutrophils recruited to HT29, HCT-116 and LoVo hepatic metastases promoted angiogenesis, potentially through the expression of fibtroblast growth factor-2. This work demonstrates a role for myeloid cells in the development of hepatic metastasis from colon cancer and in doing so identifies various potential therapeutic targets.
Subjects/Keywords: 616.99; colon cancer
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APA (6th Edition):
Gordon-Weeks, A. (2015). Identification of recruited myeloid cells important for the development of hepatic metastasis. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:fc35cc76-0a69-4b1f-b5b7-4be94df1cd36 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.711725
Chicago Manual of Style (16th Edition):
Gordon-Weeks, Alex. “Identification of recruited myeloid cells important for the development of hepatic metastasis.” 2015. Doctoral Dissertation, University of Oxford. Accessed March 07, 2021.
http://ora.ox.ac.uk/objects/uuid:fc35cc76-0a69-4b1f-b5b7-4be94df1cd36 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.711725.
MLA Handbook (7th Edition):
Gordon-Weeks, Alex. “Identification of recruited myeloid cells important for the development of hepatic metastasis.” 2015. Web. 07 Mar 2021.
Vancouver:
Gordon-Weeks A. Identification of recruited myeloid cells important for the development of hepatic metastasis. [Internet] [Doctoral dissertation]. University of Oxford; 2015. [cited 2021 Mar 07].
Available from: http://ora.ox.ac.uk/objects/uuid:fc35cc76-0a69-4b1f-b5b7-4be94df1cd36 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.711725.
Council of Science Editors:
Gordon-Weeks A. Identification of recruited myeloid cells important for the development of hepatic metastasis. [Doctoral Dissertation]. University of Oxford; 2015. Available from: http://ora.ox.ac.uk/objects/uuid:fc35cc76-0a69-4b1f-b5b7-4be94df1cd36 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.711725
Universidad de Cantabria
12.
Ovejero Gómez, Víctor Jacinto.
Determinación de biomarcadores predictivos de carcinomatosis peritoneal en cáncer de colon.
Degree: 2016, Universidad de Cantabria
URL: http://hdl.handle.net/10902/8336
► La superficie peritoneal representa la segunda localización metastásica más frecuente en cáncer de colon. Su diagnóstico supone un desafío, especialmente en etapas iniciales, lo cual…
(more)
▼ La superficie peritoneal representa la segunda localización metastásica más frecuente en cáncer de
colon. Su diagnóstico supone un desafío, especialmente en etapas iniciales, lo cual mantiene vigente la rentabilidad del “second-look”.
Una correcta identificación de factores de riesgo podría predecir la recurrencia carcinomatosa antes de que se produzca.
El análisis de estos factores nos sugiere que dicha recaída podría estar relacionada con la existencia de una carcinomatosis peritoneal sincrónica al diagnóstico, una anemia preoperatoria, un CEA patológico sérico, la infiltración serosa o de órganos vecinos, el tamaño tumoral, la presencia de depósitos tumorales mesentéricos y la infiltración perineural.
Una inmunotinción positiva para c-Met, IGF-1 o plexina β1 en el tumor primario está implicada en la recurrencia peritoneal. En cambio, la expresión del colágeno XIα1 parece ser un buen indicador de carcinoma infiltrante pero carece de valor en la predicción carcinomatosa.
La asociación estadística de estos factores nos permite aventurar un modelo matemático de fácil aplicación clínica en la determinación de este tipo de recurrencia.
Advisors/Committee Members: Freire Salinas, Francisco Javier (advisor), Universidad de Cantabria (other).
Subjects/Keywords: Cáncer de colon
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APA (6th Edition):
Ovejero Gómez, V. J. (2016). Determinación de biomarcadores predictivos de carcinomatosis peritoneal en cáncer de colon. (Doctoral Dissertation). Universidad de Cantabria. Retrieved from http://hdl.handle.net/10902/8336
Chicago Manual of Style (16th Edition):
Ovejero Gómez, Víctor Jacinto. “Determinación de biomarcadores predictivos de carcinomatosis peritoneal en cáncer de colon.” 2016. Doctoral Dissertation, Universidad de Cantabria. Accessed March 07, 2021.
http://hdl.handle.net/10902/8336.
MLA Handbook (7th Edition):
Ovejero Gómez, Víctor Jacinto. “Determinación de biomarcadores predictivos de carcinomatosis peritoneal en cáncer de colon.” 2016. Web. 07 Mar 2021.
Vancouver:
Ovejero Gómez VJ. Determinación de biomarcadores predictivos de carcinomatosis peritoneal en cáncer de colon. [Internet] [Doctoral dissertation]. Universidad de Cantabria; 2016. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/10902/8336.
Council of Science Editors:
Ovejero Gómez VJ. Determinación de biomarcadores predictivos de carcinomatosis peritoneal en cáncer de colon. [Doctoral Dissertation]. Universidad de Cantabria; 2016. Available from: http://hdl.handle.net/10902/8336
University of Aberdeen
13.
Vase, Hollie Francesca.
Interrogating therapeutic manipulation of the endocannabinoid system in the human colon.
Degree: PhD, 2013, University of Aberdeen
URL: https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12152704550005941
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.600095
► The endocannabinoid system (ECS) is known to be involved in key aspects of cell maintenance within the human colon, as well as being dysregulated in…
(more)
▼ The endocannabinoid system (ECS) is known to be involved in key aspects of cell maintenance within the human colon, as well as being dysregulated in pathophysiological conditions, including colon inflammation and cancer. However, the contribution of the ECS within each of these conditions has not been fully elucidated. This indicates that the current identification of key targets within the ECS that are involved in gut pathology could be used as potential novel therapeutics. Two experimental approaches were designed and optimised to give an insight into ECS signal regulation within the human colon and to screen ECS therapeutics, tetrahydrocannabinol (THC) and cannabidiol (CBD); a human colon ex vivo explant culture model and an innovative multiplexed quantitative gene expression technology, the GenomeLab GeXP system (Beckman Coulter). Gene targets were identified that are known markers of regulation and function in cells of healthy tissue. An assay, the hCellMarkerPlex was designed that incorporated twenty-three of these gene targets, epithelial (EZR, KRT18, SLC9A2), proliferation (PCNA, CCND1, MS4A12), differentiation (B4GANLT2, CDX1, CDX2), apoptotic (CASP3, NOX1, NTN1), fibroblast (FSP1, COL1A1), structural (ACTG2, CNN1, DES), gene transcription (HDAC1), stem cell (LGR5), endothelial (VWF) and mucin production (MUC2). The hCellMarkerPlex identified gene signatures which distinguished between normal, adenoma and carcinoma tissue, identifying cellular processes showing abnormal activity associated with pathological status. The resulting biomarker profiles were used to establish a human colon explant culture system. The human colon explant culture presents a novel model to study modulation of the ECS and screen ECS therapeutics. Combined with the GenomeLab GeXP System multiple components of the ECS were assessed at the gene regulatory level. A custom designed GeXP assay, the hECSplex, was developed. hECSplex gene expression signatures of EC receptors (CNR1, CNR2, GPR55 and TRPV1), ECS enzymes (NAPE-PLD, GDE1, DAGLA, DAGLB, FAAH, FAAH2 and PTGS2), inflammatory (IL1B, IL10, IL6, LEP, TNF and SOCS3), signalling pathway (ID1, BCL2, CFL1, BIRC5, TP53, MYC and KRAS), lipid production (SREBF1, ACACA), and plasma-membrane (OCLN) markers revealed altered expression of ECS components in carcinogenesis compared to normal tissue. Abstract vi . The hECSplex gene expression signature of colon explants showed that ECS was not altered during culture, emphasising the explant models capability as a pharmaceutical tool to test current and novel therapeutics. Applications of both THC and CBD to normal colon explants at different concentrations do not lead to any significant changes. Indicating the current pharmacological use of phytocannabinoids is causing no adverse effects in surrounding healthy colon tissue. The GenomeLab System presents new opportunities to interrogate multiple components of the endocannabinoid signalling system in small colon explant tissue samples, and in response to ECS therapeutics.
Subjects/Keywords: 613.2; Colon (Anatomy)
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APA (6th Edition):
Vase, H. F. (2013). Interrogating therapeutic manipulation of the endocannabinoid system in the human colon. (Doctoral Dissertation). University of Aberdeen. Retrieved from https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12152704550005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.600095
Chicago Manual of Style (16th Edition):
Vase, Hollie Francesca. “Interrogating therapeutic manipulation of the endocannabinoid system in the human colon.” 2013. Doctoral Dissertation, University of Aberdeen. Accessed March 07, 2021.
https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12152704550005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.600095.
MLA Handbook (7th Edition):
Vase, Hollie Francesca. “Interrogating therapeutic manipulation of the endocannabinoid system in the human colon.” 2013. Web. 07 Mar 2021.
Vancouver:
Vase HF. Interrogating therapeutic manipulation of the endocannabinoid system in the human colon. [Internet] [Doctoral dissertation]. University of Aberdeen; 2013. [cited 2021 Mar 07].
Available from: https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12152704550005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.600095.
Council of Science Editors:
Vase HF. Interrogating therapeutic manipulation of the endocannabinoid system in the human colon. [Doctoral Dissertation]. University of Aberdeen; 2013. Available from: https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12152704550005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.600095
University of Johannesburg
14.
Mayer, Aliza.
Coping styles used by patients suffering from irritable bowel syndrome.
Degree: 2012, University of Johannesburg
URL: http://hdl.handle.net/10210/5439
► M.A.
The purpose of this study was to ascertain whether patients suffering from irritable bowel syndrome (IBS) differed from non-IBS clients in terms of their…
(more)
▼ M.A.
The purpose of this study was to ascertain whether patients suffering from irritable bowel syndrome (IBS) differed from non-IBS clients in terms of their coping styles. Gastrointestinal disorders are among the most common of all illnesses; half of the population suffers from acute gastrointestinal illnesses every year (Read, 1985). More than 10% have chronic illnesses, and these illnesses are a major cause of absenteeism from work. In view of this it is surprising that there is such a faucity of psychological and psychophysiological research focusing on gastrointestinal activity. Perhaps one reason for this is that investigators conceptualise the gastrointestinal tract as a system that is unresponsive to psychological intervention. Another reason may be the widespread belief that adequate techniques are not available for studying gastrointestinal psychology and psychophysiology (Haynes & Gannon, 1981). Today there is consensus that IBS is a psychosomatic disorder that accounts for between 40 to 70% of referrals to gastroenterologists. Unfortunately, this is a very misunderstood disorder. Sufferers are often misinformed or poorly educated by their physicians. Misunderstanding and lack of patient education often results in increased anxiety and physical distress. There are cases in which unnecessary surgery, expensive diagnostic procedures and addictive pain killers are mistakenly employed. In addition, IBS patients represent an expensive group because they use up a considerable amount of medical resources in money and time (Moser, 1986).
Subjects/Keywords: Irritable colon - Research - South Africa.; Irritable colon - Patients - Research - South Africa.; Irritable colon - Psychological aspects.
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APA (6th Edition):
Mayer, A. (2012). Coping styles used by patients suffering from irritable bowel syndrome. (Thesis). University of Johannesburg. Retrieved from http://hdl.handle.net/10210/5439
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Mayer, Aliza. “Coping styles used by patients suffering from irritable bowel syndrome.” 2012. Thesis, University of Johannesburg. Accessed March 07, 2021.
http://hdl.handle.net/10210/5439.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Mayer, Aliza. “Coping styles used by patients suffering from irritable bowel syndrome.” 2012. Web. 07 Mar 2021.
Vancouver:
Mayer A. Coping styles used by patients suffering from irritable bowel syndrome. [Internet] [Thesis]. University of Johannesburg; 2012. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/10210/5439.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Mayer A. Coping styles used by patients suffering from irritable bowel syndrome. [Thesis]. University of Johannesburg; 2012. Available from: http://hdl.handle.net/10210/5439
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Delaware
15.
Modarai, Shirin Raya.
Stem cell and neuroendocrine cell phenotypes in normal and malignant colonic cells.
Degree: PhD, University of Delaware, Department of Biological Sciences, 2014, University of Delaware
URL: http://udspace.udel.edu/handle/19716/16768
► In the development of colorectal cancer (CRC), stem cell (SC) overpopulation underlies tumor initiation and progression, but the underlying mechanisms are poorly understood. We hypothesize…
(more)
▼ In the development of colorectal cancer (CRC), stem cell (SC) overpopulation underlies tumor initiation and progression, but the underlying mechanisms are poorly understood. We hypothesize that neuroendocrine cells (NE) cells play a key role in maintaining the SC population in the normal
colon and, aberrant signaling from NE cells contributes to increased "stemness" and tumor growth. Indeed, NE cells and SCs reside in close proximity to each other in the SC niche at the bottom of the normal human colonic crypt. Therefore, it seems feasible that the communication between NE cells and SCs is crucial to normal crypt homeostasis and that dysregulation of the interactions between the two cell types could lead to SC overpopulation during cancer progression. Our studies on human colonic tissues show that in normal crypts, ALDH1 + ,SSTR1+ and GLP-2R+ expressing cells are located in the SC niche and are less than 5% of the total colonic crypt cells. During stepwise progression to cancer there is a progressive increase in the proportion of ALDH+ cells and small decrease in SSTR1 and GLP-2R cells. We did further studies to assess how specific NE factors might be regulating SCs. Because we found, by flow cytometric analysis, that various CRC cell lines (COL0320, DiFi, LoVo, SW480, HCT116 & HT29) each maintains a unique proportion of SCs and NE cells over time, we surmised these proportions are maintained constant through feedback mechanisms involving SC and NE cell subpopulations. When these cell lines were induced to differentiate along the NE lineage upon retinoid treatment, they showed a decrease in the proportion of ALDH1 + cells and an increase in NE cell differentiation. Retinoid treatment that induces NE differentiation also decreased the sphere-forming ability of cells in terms of the number and sizes of spheres that were formed from each cell line. Furthermore, co-cultures with ALDH1 + and SSTR1+ cells and the addition of exogenous somatostatin to ALDH+ cells resulted in a maintenance of ALDH+ population size in the HT29 cells while in the SW480 cells, the same treatment resulted in the same maintenance of ALDH+ cells, but a decrease in total cell number and cell viability. Interestingly, inhibition of SSTR signalling resulted in a decreased percentage of ALDH+ cells and total cell number. Lastly, co-cultures with ALDH1+ and GLP-2R+ cells with the addition of exogenous glucagon-like peptide 2 to ALDH+ cells resulted in a decrease in the ALDH+ population size in both cell lines and a slight increase in total cell number. Taken together, our findings support the hypothesis that: (1) specific NE factors maintain or decrease the colonic SC population size via a paracrine mechanism in the normal
colon, and (2) dysregulation of these mechanisms contributes to increased "stemness" and tumor growth.
Advisors/Committee Members: Galileo, Deni S.Boman, Bruce.
Subjects/Keywords: Stem cells.; Paraneurons.; Cancer cells.; Colon (Anatomy); Colon (Anatomy) – Cancer – Cytopathology.; Colon (Anatomy) – Cancer – Etiology.
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APA (6th Edition):
Modarai, S. R. (2014). Stem cell and neuroendocrine cell phenotypes in normal and malignant colonic cells. (Doctoral Dissertation). University of Delaware. Retrieved from http://udspace.udel.edu/handle/19716/16768
Chicago Manual of Style (16th Edition):
Modarai, Shirin Raya. “Stem cell and neuroendocrine cell phenotypes in normal and malignant colonic cells.” 2014. Doctoral Dissertation, University of Delaware. Accessed March 07, 2021.
http://udspace.udel.edu/handle/19716/16768.
MLA Handbook (7th Edition):
Modarai, Shirin Raya. “Stem cell and neuroendocrine cell phenotypes in normal and malignant colonic cells.” 2014. Web. 07 Mar 2021.
Vancouver:
Modarai SR. Stem cell and neuroendocrine cell phenotypes in normal and malignant colonic cells. [Internet] [Doctoral dissertation]. University of Delaware; 2014. [cited 2021 Mar 07].
Available from: http://udspace.udel.edu/handle/19716/16768.
Council of Science Editors:
Modarai SR. Stem cell and neuroendocrine cell phenotypes in normal and malignant colonic cells. [Doctoral Dissertation]. University of Delaware; 2014. Available from: http://udspace.udel.edu/handle/19716/16768
Universidade do Rio Grande do Sul
16.
Bordin, Diana Lilian.
Ativação de autofagia com oxaliplatina em células de câncer colorretal.
Degree: 2013, Universidade do Rio Grande do Sul
URL: http://hdl.handle.net/10183/96855
► As céluals tumorais estão constantemente expostas a flutuações nas concentrações de nutrientes e oxigênio no microambiente tumoral. Através da ativação de diferentes vias de sinalização,…
(more)
▼ As céluals tumorais estão constantemente expostas a flutuações nas concentrações de nutrientes e oxigênio no microambiente tumoral. Através da ativação de diferentes vias de sinalização, as células tumorais sofrem uma reprogramação metabólica a fim de suportar as condições hostis impostas pelo microambiente tumoral. Uma das vias de sinalização ativada nessas condições é a autofagia, a qual tem sido considerada um dos principais mecanismos de sobrevivência celular em condições de estresse. Além disso, muitos medicamentos anti-câncer, como os agentes alquilantes, tem sido implicados na indução de autofagia. Apesar da autofagia contribuir com a sobrevivência da célula, uma superativação da via autofágica por períodos prolongados pode contribuir com a morte celular, o que faz com que o papel da autofagia no câncer seja ainda bastante debatido. Neste trabalho, buscou-se avaliar o papel da autofagia induzida em células de câncer colorretal da linhagem HCT116 continuamente cultivadas em baixa concentração de glicose e submetidas ao tratamento com o agente alquilante oxaliplatina. Os resultados demonstraram que a autofagia induzida em células HCT116 nessas condições exerce um papel citoprotetor, contribuindo para a resistência ao tratamento com oxaliplatina. A ativação da autofagia pelo tratamento com oxaliplatina em baixa concentração de glicose foi capaz de manter os níveis intracelualres de ATP e de reduzir a morte celular por apoptose. A utilização de inibidores ou de um ativador farmacológico da via autofágica, em combinação com a oxaliplatina, foi capaz de sensibilizar células HCT116 tratadas em baixa concentração de glicose, aumentando a morte celular por apoptose. Além disso, a indução de autofagia pela oxaliplatina foi mediada pela ativação de AMPK e inibição de mTOR. Estes dados demonstram que a ativação da autofagia em células de câncer colorretal HCT116 expostas a baixa concentração de glicose contribui para resistência ao tratamento com oxaliplatina. Estes dados também sugerem que a manipulação da via autofágica, pela sua inibição ou superativação, pode fornecer um maneira eficiente de limitar a progressão do tumor e aumentar a eficiência dos regimes quimioterápicos.
Tumor cells are constantly exposed to nutrients and oxygen concentration fluctuations at tumor microenvironment. Through activation of different signaling pathways, tumor cells undergo metabolic reprogramming to tolerate hostile conditions imposed by tumor microenvironment. One of the activated signaling pathways in such conditions is autophagy, which has been considered one of the central mechanisms of cell survival in stress conditions. Furthermore, many anticancer drugs, like alkylanting agents, have been implicated in autophagy induction. Despite autophagy contribution to cell survival, the autophagic pathway activation for prolonged periods may contribute to cell death, which creates extensively debates about the role of autophagy in cancer. In the present work we intended to evaluate the role of autophagy induced in colorectal cancer cells…
Advisors/Committee Members: Henriques, Joao Antonio Pegas.
Subjects/Keywords: Câncer; Colon; Oxaliplatina; Autofagia
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APA (6th Edition):
Bordin, D. L. (2013). Ativação de autofagia com oxaliplatina em células de câncer colorretal. (Thesis). Universidade do Rio Grande do Sul. Retrieved from http://hdl.handle.net/10183/96855
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Bordin, Diana Lilian. “Ativação de autofagia com oxaliplatina em células de câncer colorretal.” 2013. Thesis, Universidade do Rio Grande do Sul. Accessed March 07, 2021.
http://hdl.handle.net/10183/96855.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Bordin, Diana Lilian. “Ativação de autofagia com oxaliplatina em células de câncer colorretal.” 2013. Web. 07 Mar 2021.
Vancouver:
Bordin DL. Ativação de autofagia com oxaliplatina em células de câncer colorretal. [Internet] [Thesis]. Universidade do Rio Grande do Sul; 2013. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/10183/96855.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Bordin DL. Ativação de autofagia com oxaliplatina em células de câncer colorretal. [Thesis]. Universidade do Rio Grande do Sul; 2013. Available from: http://hdl.handle.net/10183/96855
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Utah
17.
Sandoval, Imelda Tumanan.
Dysregulation of retinoid biosynthesis and metabolism during colon carcinogenesis;.
Degree: PhD, Medicinal Chemistry;, 2006, University of Utah
URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1298/rec/362
► The research work presented in this dissertation describes the dysregulation of the retinoid biosynthetic and metabolic pathways accompanying colon carcinogenesis. Colon cancer remains the third…
(more)
▼ The research work presented in this dissertation describes the dysregulation of the retinoid biosynthetic and metabolic pathways accompanying colon carcinogenesis. Colon cancer remains the third leading cause of cancer deaths in the United States. A better understanding of the molecular mechanisms underlying colon tumorigenesis is needed to develop more effective therapies against colon cancer. Chapter 1 is an introduction on colon cancer and retinoids. The relationship between normal intestinal development and progression of colon cancer, including a background on adenomatous polyposis coli (APC) and several colorectal cancer syndromes are presented in the first half of Chapter 1. The latter part is a discussion of retinoid storage, biosynthesis and metabolism. It also summarizes what has been reported about the role of retinoids in normal colon function and their therapeutic effects on various human tumors. Retinol dehydrogenase like (DHRS9) is a colon-specific retinol dehydrogenase that is down-regulated in colon carcinomas. Chapter 2 describes studies that were undertaken to confirm the retinol dehydrogenase activity of DHRS9, demonstrate impairment of the retinoid biosynthetic capabilities of colon carcinoma cells and investigate the possible control of retinoic acid biosynthesis by APC through regulation of DHRS9 expression. A brief description of the retinol dehydrogenase activity of three zebrafish retinol dehydrogenases – rdh1, rdh1l and rdh5, is presented in Chapter 3. A discussion on the regulation of retinoid biosynthesis by APC and the importance of retinoic acid in zebrafish eye and gut development is also included. This is followed by Chapter 4, which describes significant differences in the dysregulation of the retinoid biosynthetic pathway in human colon carcinomas compared to the Apc[min/+ mouse, an established animal model system for studying colon cancer. Chapter 5 shows that the dysregulation of retinoid biosynthesis at multiple points along the pathway is a common occurrence in human colon carcinomas and colon carcinoma cell lines. Studies on cellular retinol binding protein II (CRBPII), its importance in normal intestinal development and retinol uptake are presented as well. Chapter 5 also discusses a broader role for APC in regulating intestinal differentiation by controlling several retinoid biosynthetic components. Conclusions and implications of presented findings are discussed in Chapter 6.
Subjects/Keywords: Colon; Retinoids
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Export
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APA (6th Edition):
Sandoval, I. T. (2006). Dysregulation of retinoid biosynthesis and metabolism during colon carcinogenesis;. (Doctoral Dissertation). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1298/rec/362
Chicago Manual of Style (16th Edition):
Sandoval, Imelda Tumanan. “Dysregulation of retinoid biosynthesis and metabolism during colon carcinogenesis;.” 2006. Doctoral Dissertation, University of Utah. Accessed March 07, 2021.
http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1298/rec/362.
MLA Handbook (7th Edition):
Sandoval, Imelda Tumanan. “Dysregulation of retinoid biosynthesis and metabolism during colon carcinogenesis;.” 2006. Web. 07 Mar 2021.
Vancouver:
Sandoval IT. Dysregulation of retinoid biosynthesis and metabolism during colon carcinogenesis;. [Internet] [Doctoral dissertation]. University of Utah; 2006. [cited 2021 Mar 07].
Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1298/rec/362.
Council of Science Editors:
Sandoval IT. Dysregulation of retinoid biosynthesis and metabolism during colon carcinogenesis;. [Doctoral Dissertation]. University of Utah; 2006. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1298/rec/362
18.
Kalantzis, Ioannis.
Κλινικοπαθολογοανατομικές διαφορές και συσχετίσεις μεταξύ καρκίνου του δεξιού και αριστερού τμήματος του παχέος εντέρου.
Degree: 2020, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)
URL: http://hdl.handle.net/10442/hedi/47890
► Background: The differences in histopathology and molecular biology between right colon cancer (RCC) and left colon cancer (LCC) were first reported in the literature by…
(more)
▼ Background: The differences in histopathology and molecular biology between right colon cancer (RCC) and left colon cancer (LCC) were first reported in the literature by Bufill in 1990. Since then, a large number of studies have confirmed their differences in epidemiology, clinical presentation, comorbidities and biological behaviour, which may be related to the difference in prognosis and overall survival (OS) between the two groups. Aim: To investigate statistically significant differences between Greek patients with LCC and RCC in terms of epidemiology, clinical manifestation, histopathology and molecular biology, taking into consederaration the response rates in targeted regimens in first and second line chemotherapy and overall survival. Methods: The present observational study included 144 patients diagnosed with colon cancer of any stage who received chemotherapy in a Greek tertiary oncology hospital during a 2.5-year period. Clinical information, comorbidities, histopathologic characteristics and molecular biomarkers were collected from the patients’ medical records retrospectively, while administered chemotherapy regimens, targeted agents, progression-free survival (PFS) periods with first- and second-line chemotherapy and OS were recorded retroactively and prospectively. Data analysis was performed with the SPSS statistical package. Results: Eighty-six males and 58 females participated in the study. One hundred (69.4%) patients had a primary lesion in the left colon, and 44 (30.6%) patients had a primary lesion in the right colon. Patients with RCC were more likely to display anaemia than patients with LCC (OR = 3.09), while LCC patients were more likely to develop rectal bleeding (OR = 3.37) and a feeling of incomplete evacuation (OR = 2.78). Considering comorbidities, RCC patients were more likely to suffer from diabetes (OR = 3.31) and coronary artery disease (p = 0.056) than LCC patients. The mucinous differentiation rate was higher in the right-sided group than in the left-sided group (OR = 4.49), as was the number of infiltrated lymph nodes (p = 0.039), while the percentage of high-grade differentiation was higher in the group of patients with left-sided colon cancer (OR = 2.78). RAS wild-type patients who received anti-EGFR treatment experienced greater benefit (PFS: 16.5 mo) than those who received anti-VEGF treatment (PFS: 13.7 mo) (p = 0.05), while among RAS wild-type patients who received anti-EGFR treatment, LCC patients experienced greater benefit (PFS: 15.8 mo) than the RCC subgroup (PFS: 5.5 mo) in the first-line chemotherapy setting (p = 0.034). BRAF-mutant patients had shorter PFS (9.3 mo) than BRAF wild-type patients (14.5 mo) (p = 0.033). RCC patients showed a shorter tumour recurrence period (7.7 mo) than those with LCC (14.5 mo) (p < 0.001), as well as shorter overall survival (58.4 mo for RCC patients; 82.4 mo for LCC patients) (p = 0.018). Conclusion: RCC patients present more comorbidities, worse histological and molecular characteristics and a consequently higher probability of…
Subjects/Keywords: Καρκίνος παχέος εντέρου; Colon cancer
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APA (6th Edition):
Kalantzis, I. (2020). Κλινικοπαθολογοανατομικές διαφορές και συσχετίσεις μεταξύ καρκίνου του δεξιού και αριστερού τμήματος του παχέος εντέρου. (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/47890
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Kalantzis, Ioannis. “Κλινικοπαθολογοανατομικές διαφορές και συσχετίσεις μεταξύ καρκίνου του δεξιού και αριστερού τμήματος του παχέος εντέρου.” 2020. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed March 07, 2021.
http://hdl.handle.net/10442/hedi/47890.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Kalantzis, Ioannis. “Κλινικοπαθολογοανατομικές διαφορές και συσχετίσεις μεταξύ καρκίνου του δεξιού και αριστερού τμήματος του παχέος εντέρου.” 2020. Web. 07 Mar 2021.
Vancouver:
Kalantzis I. Κλινικοπαθολογοανατομικές διαφορές και συσχετίσεις μεταξύ καρκίνου του δεξιού και αριστερού τμήματος του παχέος εντέρου. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2020. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/10442/hedi/47890.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Kalantzis I. Κλινικοπαθολογοανατομικές διαφορές και συσχετίσεις μεταξύ καρκίνου του δεξιού και αριστερού τμήματος του παχέος εντέρου. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2020. Available from: http://hdl.handle.net/10442/hedi/47890
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Columbia University
19.
Baldera Aguayo, Pedro Alexis.
Engineering yeasts for in situ production of fungal tetracyclines.
Degree: 2020, Columbia University
URL: https://doi.org/10.7916/d8-knc4-ba09
► Synthetic biology consists of the design and construction of customized cell-based systems, and metabolic engineering is its co-discipline that aims to engineer these cells into…
(more)
▼ Synthetic biology consists of the design and construction of customized cell-based systems, and metabolic engineering is its co-discipline that aims to engineer these cells into biological factories for the production of drugs, chemical commodities and fuels. Together, these two disciplines continue to provide various innovative solutions to current problems of humanity in the areas of medicine, agriculture and energy. In this dissertation, we use synthetic biology and metabolic engineering approaches to explore the potential of engineered live yeasts as therapeutic platforms for treating inflammatory bowel disease (IBD). The vast majority of microbial-based therapeutics at the moment have focused on bacteria instead of yeasts, and all of these engineered live bacterial platforms use either proteins or peptides as therapeutic agents of choice. This dissertation seeks to enhance yeast’s beneficial properties to humans by genetically engineering them to produce TAN-1612, a small molecule tetracycline with therapeutic potential.
We choose tetracyclines as our small molecule therapeutic agent because these compounds are one of the most impactful natural products that humanity has benefited from due to its significant antimicrobial and anti-inflammatory properties. We genetically engineer strains of baker’s yeast Saccharomyces cerevisiae and the probiotic yeast Saccharomyces cerevisiae var boulardii to produce in situ the fungal tetracycline TAN-1612, a natural product with anti-inflammatory properties (instead of anti-microbial so as to not disturb the gut microbiome), and to study the molecular mechanisms involved in their potential beneficial effects for IBD. Our engineered live yeast therapeutics would provide an effective, safe, and cheap alternative to treating IBD and other gastrointestinal tract disorders compared to the currently available but costly and laborious therapies.
In Chapter 1, we review key milestones in the fields of synthetic biology and metabolic engineering that have enabled and inspired the generation of both engineered live microbial-based systems and small molecules as the therapeutic agents for the potential treatment of a wide array of human diseases such IBD, cancer, and pathogenic infections. In Chapter 2, we develop synthetic biology and metabolic engineering approaches for designing, building, and testing of the biosynthetic pathway of TAN-1612 in genetically engineered yeasts such as S. cerevisiae and S. boulardii. These approaches enable the production of TAN-1612 in yeasts with titers as high as ~61 mg/L which represent a 100-fold improvement from previous reported yeast strains. These engineering approaches hold great potential to advance the heterologous biosynthesis of other small molecule therapeutics in yeasts. In Chapter 3, we explore the role of TAN-1612 as an anti-inflammatory agent, inhibitor of tetracycline inactivating enzymes, and inducer of gene expression with the goal of identifying its best therapeutic or biological application that can be leveraged for…
Subjects/Keywords: Chemistry; Yeast; Tetracycline; Irritable colon
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APA (6th Edition):
Baldera Aguayo, P. A. (2020). Engineering yeasts for in situ production of fungal tetracyclines. (Doctoral Dissertation). Columbia University. Retrieved from https://doi.org/10.7916/d8-knc4-ba09
Chicago Manual of Style (16th Edition):
Baldera Aguayo, Pedro Alexis. “Engineering yeasts for in situ production of fungal tetracyclines.” 2020. Doctoral Dissertation, Columbia University. Accessed March 07, 2021.
https://doi.org/10.7916/d8-knc4-ba09.
MLA Handbook (7th Edition):
Baldera Aguayo, Pedro Alexis. “Engineering yeasts for in situ production of fungal tetracyclines.” 2020. Web. 07 Mar 2021.
Vancouver:
Baldera Aguayo PA. Engineering yeasts for in situ production of fungal tetracyclines. [Internet] [Doctoral dissertation]. Columbia University; 2020. [cited 2021 Mar 07].
Available from: https://doi.org/10.7916/d8-knc4-ba09.
Council of Science Editors:
Baldera Aguayo PA. Engineering yeasts for in situ production of fungal tetracyclines. [Doctoral Dissertation]. Columbia University; 2020. Available from: https://doi.org/10.7916/d8-knc4-ba09
University of Minnesota
20.
Chow, Christopher J.
Does patient rurality predict quality colon cancer care?
a population based study.
Degree: MS, Clinical Research, 2013, University of Minnesota
URL: http://purl.umn.edu/157355
► University of Minnesota M.S. thesis. June 2013. Major: Clinical Research. Advisor: David A. Rothenberger, MD. 1 computer file (PDF); vi, 22 pages.
Introduction: Over fifty…
(more)
▼ University of Minnesota M.S. thesis. June 2013.
Major: Clinical Research. Advisor: David A. Rothenberger, MD. 1
computer file (PDF); vi, 22 pages.
Introduction: Over fifty million people reside in
rural America. However, the impact of patient rurality on colon
cancer care has been incompletely characterized. We hypothesize
that patient rurality impacts colon cancer care quality measures.
Methods:Using the 1996-2008 California Cancer Registry, we
identified 123,129 patients with stage 0-IV colon cancer. Baseline
characteristics were compared by rurality status. Controlling for
covariates, multivariate regression models were used to examine the
impact of rurality on stage, adequate lymphadenectomy and receipt
of chemotherapy. Cox proportional hazards was used to examine
cancer specific survival. Results: Of our cohort, 18,735 (15%)
resided in rural areas. Rural residence was associated with white
or American Indian race. Controlling for covariates, our
multivariate models demonstrate that rurality was associated with
later stage of diagnosis, inadequate lymphadenectomy and inadequate
receipt of chemotherapy. In addition, rurality was associated with
worse cancer specific survival. Conclusions: A significant
proportion of patients treated for colon cancer live in rural
areas. Yet, rural residence is associated with later stage, poor
adherence to quality measures and poorer survival. Future quality
improvement measures should target rural patients to ensure both
that structure of care is optimal and that appropriate processes of
care are followed.
Advisors/Committee Members: David A. Rothenberger, MD.
Subjects/Keywords: Adenocarcinoma; Colon; Outcomes; Quality
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APA (6th Edition):
Chow, C. J. (2013). Does patient rurality predict quality colon cancer care?
a population based study. (Masters Thesis). University of Minnesota. Retrieved from http://purl.umn.edu/157355
Chicago Manual of Style (16th Edition):
Chow, Christopher J. “Does patient rurality predict quality colon cancer care?
a population based study.” 2013. Masters Thesis, University of Minnesota. Accessed March 07, 2021.
http://purl.umn.edu/157355.
MLA Handbook (7th Edition):
Chow, Christopher J. “Does patient rurality predict quality colon cancer care?
a population based study.” 2013. Web. 07 Mar 2021.
Vancouver:
Chow CJ. Does patient rurality predict quality colon cancer care?
a population based study. [Internet] [Masters thesis]. University of Minnesota; 2013. [cited 2021 Mar 07].
Available from: http://purl.umn.edu/157355.
Council of Science Editors:
Chow CJ. Does patient rurality predict quality colon cancer care?
a population based study. [Masters Thesis]. University of Minnesota; 2013. Available from: http://purl.umn.edu/157355
Penn State University
21.
Brownschidle, Amy Laura.
The Effect of Soy Protein on Colon Carcinogenesis in vitro and in vivo
.
Degree: 2011, Penn State University
URL: https://submit-etda.libraries.psu.edu/catalog/12055
► Previous studies have suggested a beneficial effect of dietary soy against inflammation and colon cancer. Much of this has been attributed to soy isoflavones; however,…
(more)
▼ Previous studies have suggested a beneficial effect of dietary soy against inflammation and
colon cancer. Much of this has been attributed to soy isoflavones; however, soy proteins and peptides have also shown bioactivity and antioxidant activity in some models. Enzymatic hydrolysis of proteins has also been shown to increase free radical scavenging by increasing solvent accessibility of active amino acids.
We investigated the antioxidant capacity of an isoflavone-free soy protein concentrate (SPC) and an enzymatically-hydrolyzed SPC (SPH) using the oxygen radical absorbance capacity (ORAC) assay. Consistent with our expectations, SPH delayed the oxidation of fluorescein significantly longer than SPC (p<0.01), indicating its superior antioxidative capacity.
The cytoprotective effects of SPC and SPH were also compared in the Caco-2 human intestinal cell model to evaluate their ability to prevent H2O2-induced oxidation. Cells were cotreated with 50 µM H2O2 and SPC or SPH (0-2 mg/ml) in PBS for 60 min or were pretreated with SPC or SPH (0-2 mg/ml) for 30 min and subsequently treated with 50 µM H2O2 for 60 min. Cell viability was assessed using the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) assay. Treatment with 0.5 mg/ml SPC increased cell viability from 42.8-50.0% in H2O2-only treated cells to 76.1 ± 9.0% and 60.8 ± 6.5% of the PBS control in the cotreatment and pretreatment trials, respectively. Higher concentrations of SPH were required to achieve similar cytoprotective effects. At a concentration of 2 mg/ml SPH, cell viability was increased to 85.3 ± 10.9% and 62.1 ± 3.2% in the cotreatment and pretreatment trials, respectively. Photomicrographs of treated cells showed that SPC prevented H2O2-induced changes in morphology and reduced intracellular reactive oxygen species (ROS). These effects were also observed for SPH treatment, but to a lesser extent.
The effect of dietary supplementation with SPC on
colon inflammation and carcinogenesis in male, CF-1 mice was investigated in one 10-week and one 20-week study. In both studies, following one week pretreatment with SPC or casein as the sole source of protein (19% kcal), mice were injected with the
colon carcinogen azoxymethane (AOM, 10 mg/kg body wt). One week later, mice received dextran sodium sulfate (DSS, 1.5% w/v) as their sole drinking fluid for one week to induce
colon-specific inflammation. On days 3 and 7, and weeks 7 and 20 (second study only) after DSS treatment, mice were euthanized and the colons were examined for markers of inflammation and carcinogenesis. All samples were scored using the inflammation index, which measures inflammation area, severity, ulceration and hyperplasia and dysplasia. In both studies, trends in these measures appeared to be highly dependent on sacrifice time-point. With the data from both studies combined, mean polyp multiplicity was significantly reduced in mice fed SPC at Week 7 and for the study overall (p<0.001 and p<0.01, respectively). Hyperplasia and dysplasia, inflammation…
Advisors/Committee Members: Joshua D Lambert, Thesis Advisor/Co-Advisor, Ryan John Elias, Thesis Advisor/Co-Advisor, Joshua D Lambert, Thesis Advisor/Co-Advisor.
Subjects/Keywords: Soy protein; colon cancer
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APA ·
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APA (6th Edition):
Brownschidle, A. L. (2011). The Effect of Soy Protein on Colon Carcinogenesis in vitro and in vivo
. (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/12055
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Brownschidle, Amy Laura. “The Effect of Soy Protein on Colon Carcinogenesis in vitro and in vivo
.” 2011. Thesis, Penn State University. Accessed March 07, 2021.
https://submit-etda.libraries.psu.edu/catalog/12055.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Brownschidle, Amy Laura. “The Effect of Soy Protein on Colon Carcinogenesis in vitro and in vivo
.” 2011. Web. 07 Mar 2021.
Vancouver:
Brownschidle AL. The Effect of Soy Protein on Colon Carcinogenesis in vitro and in vivo
. [Internet] [Thesis]. Penn State University; 2011. [cited 2021 Mar 07].
Available from: https://submit-etda.libraries.psu.edu/catalog/12055.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Brownschidle AL. The Effect of Soy Protein on Colon Carcinogenesis in vitro and in vivo
. [Thesis]. Penn State University; 2011. Available from: https://submit-etda.libraries.psu.edu/catalog/12055
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Texas A&M University
22.
Curry, Christina Alison.
Chemoprotective Effects of Flaxseed Lignans Enterodiol and Enterolactone in Non-transformed Colonocytes.
Degree: MS, Nutrition, 2015, Texas A&M University
URL: http://hdl.handle.net/1969.1/156226
► Previous epidemiological studies have shown that colon cancer incidence is correlated to diet and estrogen status. Phytoestrogens are molecules with similar structures to estrogen that…
(more)
▼ Previous epidemiological studies have shown that
colon cancer incidence is correlated to diet and estrogen status. Phytoestrogens are molecules with similar structures to estrogen that occur naturally in plants. There is in vitro and in vivo evidence that phytoestrogens in the diet can inhibit carcinogenesis. The phytoestrogenic mammalian lignans enterolactone (EL) and enterodiol (ED) in flaxseed have been shown to be effective in decreasing tumor incidence in carcinogenic models, but there is little data regarding their effects in non-malignant cells. The following studies used a nontransformed cell line of young adult mouse colonocytes (YAMC) to determine the protective effects of ED and EL in chemoprevention.
Our results demonstrate that low levels of EL (1μM) and ED (5μM) are effective at significantly reducing cell growth and increasing apoptosis. These treatments also regulated transcription via significant differences in gene levels related to apoptosis and cell cycle progression. The data collected demonstrate some of the physiological effects of EL and ED on the cellular and molecular level. These changes may contribute to the overall effect of prevention of
colon cancer carcinogenesis seen with flaxseed consumption.
Advisors/Committee Members: Allred, Clinton (advisor), Awika , Joseph (committee member), Anding , Jenna (committee member).
Subjects/Keywords: Colon cancer; flaxseed; lignans; phytoestrogens
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APA (6th Edition):
Curry, C. A. (2015). Chemoprotective Effects of Flaxseed Lignans Enterodiol and Enterolactone in Non-transformed Colonocytes. (Masters Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/156226
Chicago Manual of Style (16th Edition):
Curry, Christina Alison. “Chemoprotective Effects of Flaxseed Lignans Enterodiol and Enterolactone in Non-transformed Colonocytes.” 2015. Masters Thesis, Texas A&M University. Accessed March 07, 2021.
http://hdl.handle.net/1969.1/156226.
MLA Handbook (7th Edition):
Curry, Christina Alison. “Chemoprotective Effects of Flaxseed Lignans Enterodiol and Enterolactone in Non-transformed Colonocytes.” 2015. Web. 07 Mar 2021.
Vancouver:
Curry CA. Chemoprotective Effects of Flaxseed Lignans Enterodiol and Enterolactone in Non-transformed Colonocytes. [Internet] [Masters thesis]. Texas A&M University; 2015. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/1969.1/156226.
Council of Science Editors:
Curry CA. Chemoprotective Effects of Flaxseed Lignans Enterodiol and Enterolactone in Non-transformed Colonocytes. [Masters Thesis]. Texas A&M University; 2015. Available from: http://hdl.handle.net/1969.1/156226
Texas A&M University
23.
Triff, Karen.
Assessment of Histone Tail Modifications and Transcriptional Profiling during Colon Cancer Progression: Effect of Chemoprotective Natural Compounds.
Degree: PhD, Microbiology, 2016, Texas A&M University
URL: http://hdl.handle.net/1969.1/156811
► During colon cancer development, epigenetic alterations contribute to the dysregulation of major cellular functions and signaling pathways. Recent evidence suggests that nutritionally chemoprotective components that…
(more)
▼ During
colon cancer development, epigenetic alterations contribute to the dysregulation of major cellular functions and signaling pathways. Recent evidence suggests that nutritionally chemoprotective components that influence cellular dynamics in the colonic epithelium can also directly affect their epigenetic landscape. We hypothesize that the chemoprotective nutritional bioactives found in fish oil and fermentable fiber can act as epigenetic modifiers and mechanistically counteract epigenetic distortions associated with colonic tumorigenesis. Fermentable fiber generates short-chain fatty acids (SCFA), e.g., butyrate, in the lumen of the
colon that can serve as a chemoprotective histone deacetylase inhibitor and/or as an acetylation substrate for histone acetylases. In addition, n-3 polyunsaturated fatty acids (n-3 PUFAs) in fish oil can affect the chromatin landscape by acting as ligands for tumor suppressive nuclear receptors.
In an effort to gain insight into the extensive dimension of post-translational modifications in histones (including H3K4me3 and H3K9ac) and elucidate the chemoprotective impact of dietary bioactive compounds on transcriptional control in a
colon cancer preclinical model, we generated high-resolution genome-wide RNA (RNA-Seq) and “chromatin-state” (H3K4me3-seq and H3K9ac-seq) maps for intestinal (epithelial colonocytes) crypts in rats treated with a
colon carcinogen and fed bioactive (i) fish oil (ii) butyrate (in the form of a fermentable fiber a rich source of SCFA), (iii) a combination of fish oil plus butyrate or (iv) control diets.
Poor correlation was observed between differentially transcribed (DE) and enriched genes (DERs) at multiple epigenetic levels in fat x fiber dietary combinations and in the presence/absence of carcinogen. The genome-wide carcinogen (AOM) effects were most prevalent at the RNA (116 DE genes) and K4me3 (7678 DERs including 3792 genes) levels. Pathway analysis of the differentially transcribed genes after AOM exposure indicated a strong link to interferon-associated innate immune responses often associated with anti-microbial activity, while K4me3 DERs were strongly linked to
colon tumorigenesis. However, these changes in K4me3 enrichment were not reflected at the transcriptional level during the early stages of cancer progression. Therefore, we propose that carcinogen-induced changes in genes with K4me3 DERs are harbingers of future transcriptional events, which drive malignant transformation of the
colon cells.
We also demonstrated that the combinatorial diet (fish oil + pectin) was synergistically chemoprotective, and uniquely affected epigenetic profiles in the intestinal epithelium, e.g., upregulating lipid catabolism and beta-oxidation associated genes. These genes were linked to activated ligand-dependent nuclear receptors associated with n-3 PUFAs and were also correlated with the inhibition of lipogenesis and a decreased concentration of cholesterol. Interestingly, only a subset of these genes was affected in animals fed fish oil without pectin, and…
Advisors/Committee Members: Chapkin, Robert S (advisor), Zoran, Mark (advisor), Gomer, Richard (committee member), Lupton, Joanne (committee member).
Subjects/Keywords: epigenetics; colon cancer; chemoprevention
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APA (6th Edition):
Triff, K. (2016). Assessment of Histone Tail Modifications and Transcriptional Profiling during Colon Cancer Progression: Effect of Chemoprotective Natural Compounds. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/156811
Chicago Manual of Style (16th Edition):
Triff, Karen. “Assessment of Histone Tail Modifications and Transcriptional Profiling during Colon Cancer Progression: Effect of Chemoprotective Natural Compounds.” 2016. Doctoral Dissertation, Texas A&M University. Accessed March 07, 2021.
http://hdl.handle.net/1969.1/156811.
MLA Handbook (7th Edition):
Triff, Karen. “Assessment of Histone Tail Modifications and Transcriptional Profiling during Colon Cancer Progression: Effect of Chemoprotective Natural Compounds.” 2016. Web. 07 Mar 2021.
Vancouver:
Triff K. Assessment of Histone Tail Modifications and Transcriptional Profiling during Colon Cancer Progression: Effect of Chemoprotective Natural Compounds. [Internet] [Doctoral dissertation]. Texas A&M University; 2016. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/1969.1/156811.
Council of Science Editors:
Triff K. Assessment of Histone Tail Modifications and Transcriptional Profiling during Colon Cancer Progression: Effect of Chemoprotective Natural Compounds. [Doctoral Dissertation]. Texas A&M University; 2016. Available from: http://hdl.handle.net/1969.1/156811
Texas A&M University
24.
Mann, John Clifford.
The effects of diet and ionizing radiation on azoxymethane induced colon carcinogenesis.
Degree: MS, Nutrition, 2006, Texas A&M University
URL: http://hdl.handle.net/1969.1/4250
► The ability of ionizing radiation to enhance colon carcinogenesis and the role of diet in this process has not been documented. We hypothesized that radiation…
(more)
▼ The ability of ionizing radiation to enhance
colon carcinogenesis and the role of diet in this process has not been documented. We hypothesized that radiation would enhance the formation of aberrant crypt foci, ACF, known precursor lesions to
colon cancer, by suppressing apoptosis and upregulating proliferation in colonocytes. Diets contained a combination of fish oil or corn oil and either pectin or cellulose. We exposed 40 male Sprague-Dawley rats to 1 Gy ionizing radiation (1 GeV Fe) 10 d prior to injection with AOM. Colons were resected at the promotion stage of carcinogenesis (7 wk post initial injection) and assayed for ACF and apoptosis. Radiation treatment increased (P=0.0327) the incidence of high multiplicity ACF (foci with four or more aberrant crypts) and decreased (P=0.0340) the apoptotic index compared to non-irradiated rats. Radiation also resulted in an increase (P<0.0001) in the proliferative index compared to the nonirradiated rats. The fish oil containing diets resulted in fewer (P=0.0002) high-multiplicity ACF compared to the corn oil treatment. Dietary pectin significantly increased (P=0.0204) the apoptotic index compared to cellulose treatment. These data suggest that ionizing radiation can work synergistically with AOM and increase the formation of high-multiplicity ACF, upregulate cellular proliferation and decrease apoptosis in colonocytes. The data also suggest that diets containing fish oil and pectin may protect against
colon cancer by increasing apoptosis and reducing the formation of high multiplicity ACF.
Advisors/Committee Members: Lupton, Joanne R. (advisor), Chapkin, Robert S. (committee member), Mallick, Bani (committee member), Turner, Nancy D. (committee member).
Subjects/Keywords: radiation; colon
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APA (6th Edition):
Mann, J. C. (2006). The effects of diet and ionizing radiation on azoxymethane induced colon carcinogenesis. (Masters Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/4250
Chicago Manual of Style (16th Edition):
Mann, John Clifford. “The effects of diet and ionizing radiation on azoxymethane induced colon carcinogenesis.” 2006. Masters Thesis, Texas A&M University. Accessed March 07, 2021.
http://hdl.handle.net/1969.1/4250.
MLA Handbook (7th Edition):
Mann, John Clifford. “The effects of diet and ionizing radiation on azoxymethane induced colon carcinogenesis.” 2006. Web. 07 Mar 2021.
Vancouver:
Mann JC. The effects of diet and ionizing radiation on azoxymethane induced colon carcinogenesis. [Internet] [Masters thesis]. Texas A&M University; 2006. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/1969.1/4250.
Council of Science Editors:
Mann JC. The effects of diet and ionizing radiation on azoxymethane induced colon carcinogenesis. [Masters Thesis]. Texas A&M University; 2006. Available from: http://hdl.handle.net/1969.1/4250
University of Johannesburg
25.
Schultz, Jacquelyn Loren.
A study to determine the effectiveness of the homoeopathic remedies Argentum nitricum 6CH and Lycopodium clavatum 6CH on the individualised treatment of patients suffering from irritable bowel syndrome.
Degree: 2014, University of Johannesburg
URL: http://hdl.handle.net/10210/10589
► M.Tech. (Homoeopathy)
The aim of this study was to determine the effectiveness of Argentum nitricum 6CH and Lycopodium clavatum 6CH in the individualised treatment of…
(more)
▼ M.Tech. (Homoeopathy)
The aim of this study was to determine the effectiveness of Argentum nitricum 6CH and Lycopodium clavatum 6CH in the individualised treatment of patients suffering from Irritable bowel syndrome. These two homoeopathic remedies are well known for their effect on the gastrointestinal system, especially when the gastrointestinal symptoms are associated with emotional stress. 60 subjects participated in this single blind, placebo controlled study. Each subject underwent an initial evaluation in order to ascertain their symptoms prior to treatment. They were then given their appropriate remedy to be administered three times daily for one month. The subject's symptoms were monitored through questionnaires completed at two week intervals. The homoeopathic medication appeared to reduce the Irritable bowel syndrome symptoms, with the Lycopodium clavatum group achieving slightly better results than the Argentum nitricum group. It is, however, recommended that further similar studies using a larger sample group for a longer duration be conducted in order to verify these findings.
Subjects/Keywords: Irritable colon - Homeopathic treatment
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APA (6th Edition):
Schultz, J. L. (2014). A study to determine the effectiveness of the homoeopathic remedies Argentum nitricum 6CH and Lycopodium clavatum 6CH on the individualised treatment of patients suffering from irritable bowel syndrome. (Thesis). University of Johannesburg. Retrieved from http://hdl.handle.net/10210/10589
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Schultz, Jacquelyn Loren. “A study to determine the effectiveness of the homoeopathic remedies Argentum nitricum 6CH and Lycopodium clavatum 6CH on the individualised treatment of patients suffering from irritable bowel syndrome.” 2014. Thesis, University of Johannesburg. Accessed March 07, 2021.
http://hdl.handle.net/10210/10589.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Schultz, Jacquelyn Loren. “A study to determine the effectiveness of the homoeopathic remedies Argentum nitricum 6CH and Lycopodium clavatum 6CH on the individualised treatment of patients suffering from irritable bowel syndrome.” 2014. Web. 07 Mar 2021.
Vancouver:
Schultz JL. A study to determine the effectiveness of the homoeopathic remedies Argentum nitricum 6CH and Lycopodium clavatum 6CH on the individualised treatment of patients suffering from irritable bowel syndrome. [Internet] [Thesis]. University of Johannesburg; 2014. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/10210/10589.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Schultz JL. A study to determine the effectiveness of the homoeopathic remedies Argentum nitricum 6CH and Lycopodium clavatum 6CH on the individualised treatment of patients suffering from irritable bowel syndrome. [Thesis]. University of Johannesburg; 2014. Available from: http://hdl.handle.net/10210/10589
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Universidad de Valladolid
26.
Herranz Bachiller, María Teresa.
Papel de la calprotectina fecal como predictor de enfermedad orgánica: aplicabilidad en la diarrea crónica y la recurrencia endoscópica de la enfermedad de Crohn.
Degree: 2016, Universidad de Valladolid
URL: http://uvadoc.uva.es/handle/10324/16869
► Introducción: La diarrea crónica es una patología frecuente en la consulta de aparato digestivo. La causa más común de diarrea son los trastornos funcionales, la…
(more)
▼ Introducción: La diarrea crónica es una patología frecuente en la consulta de aparato digestivo. La causa más común de diarrea son los trastornos funcionales, la diferenciación entre patología orgánica de funcional puede conllevar la realización de muchas pruebas complementarias, entre ellas la colonoscopia. La demanda creciente de endoscopias hace necesario la búsqueda de un marcador sensible y específico que nos permita clasificar a los pacientes de forma segura y así evitar colonoscopias innecesarias. La calprotectina fecal es un marcador biológico de inflamación intestinal utilizado generalmente para el diagnóstico y seguimiento de la EII. En el presente estudio valoraremos el papel de la calprotectina fecal como indicador de patología intestinal en la diarrea crónica y para establecer la necesidad de una colonoscopia, así como, su utilidad en la recurrencia endoscópica de la enfermedad de Crohn.
Material y métodos: Se trata de un estudio retrospectivo observacional dividido en dos partes; la primera pacientes en estudio por diarrea crónica con una determinación de calprotectina fecal y colonoscopia con biopsias, en este estudio se valoraran dos tipos de calprotectina fecal ( ELISA y ELiA), lo cual nos obliga a analizar la calprotectina fecal como variable continua y discontinua. La segunda parte analiza pacientes con enfermedad de Crohn operados a los que se realiza una colonoscopia de control. En ambos se realizaran estudios univariantes y multivariantes para la determinación de variables predictoras; así como búsqueda de puntos de corte mediante curvas ROC. En el primero además realizaremos scores diagnósticos a partir de un análisis de regresión logística binario.
Resultados: La CF, es la variable discontinua que ofrece una mayor sensibilidad (91,8%) y VPN (94%) para la colonoscopia con hallazgos de gravedad y la varibale que obtiene mayor puntuación en el score diagnóstico. También es la variable más sensible para EII (100%, 100%), para CM (63,6%, 91,1%). Para el CCR solo presento una sensibilidad del 71,4%, siendo la PCR la variable más sensible. La presencia de pólipos, divertículos, el tratamiento con AINEs, o IBPS y la edad se asocia a niveles de CF más elevados, mientras que el tabaquismo reduce estos valores. El valor de la CF aumenta según aumenta el índice de Rutgeerts. El AUC de la CF en la recurrencia endoscópica es 0.74 con un punto de corte óptimo de 60mcg/g con una S 88% y E 58% en detectar recurrencia.
Conclusiones: La CF es un test útil y eficaz en pacientes con diarrea crónica, puesto que, es la variable que presenta mayor sensibilidad y VPN de entre todas las variables recogidas como predictora de hallazgos de gravedad en la colonoscopia. No es un buen marcador de CCR dada su baja sensibilidad y no es un buen indicador de toma de biopsias para descartar CM. Es necesario que la estandarización de los métodos de medición de CF. Es el test con mayor capacidad predictiva de la recurrencia endoscópica en la EC, pero de momento no puede sustituir a la colonoscopia.
Subjects/Keywords: Crohn, Enfermedad de; Colon-Enfermedades
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APA (6th Edition):
Herranz Bachiller, M. T. (2016). Papel de la calprotectina fecal como predictor de enfermedad orgánica: aplicabilidad en la diarrea crónica y la recurrencia endoscópica de la enfermedad de Crohn. (Thesis). Universidad de Valladolid. Retrieved from http://uvadoc.uva.es/handle/10324/16869
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Herranz Bachiller, María Teresa. “Papel de la calprotectina fecal como predictor de enfermedad orgánica: aplicabilidad en la diarrea crónica y la recurrencia endoscópica de la enfermedad de Crohn.” 2016. Thesis, Universidad de Valladolid. Accessed March 07, 2021.
http://uvadoc.uva.es/handle/10324/16869.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Herranz Bachiller, María Teresa. “Papel de la calprotectina fecal como predictor de enfermedad orgánica: aplicabilidad en la diarrea crónica y la recurrencia endoscópica de la enfermedad de Crohn.” 2016. Web. 07 Mar 2021.
Vancouver:
Herranz Bachiller MT. Papel de la calprotectina fecal como predictor de enfermedad orgánica: aplicabilidad en la diarrea crónica y la recurrencia endoscópica de la enfermedad de Crohn. [Internet] [Thesis]. Universidad de Valladolid; 2016. [cited 2021 Mar 07].
Available from: http://uvadoc.uva.es/handle/10324/16869.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Herranz Bachiller MT. Papel de la calprotectina fecal como predictor de enfermedad orgánica: aplicabilidad en la diarrea crónica y la recurrencia endoscópica de la enfermedad de Crohn. [Thesis]. Universidad de Valladolid; 2016. Available from: http://uvadoc.uva.es/handle/10324/16869
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Delaware
27.
Viswanathan, Vignesh.
MicroRNAs in normal and malignant colon stem cells and their possible role in stem cell origin of colon cancer.
Degree: PhD, University of Delaware, Department of Department
Biological Sciences, 2014, University of Delaware
URL: http://udspace.udel.edu/handle/19716/16788
► The role of miRNAs in colon cancer development pertaining specifically to the stem cell origin of cancer is yet to be elucidated. We hypothesized that…
(more)
▼ The role of miRNAs in
colon cancer development pertaining specifically to the stem cell origin of cancer is yet to be elucidated. We hypothesized that perturbation of miR expression levels contributes to changes in target gene belonging to self-renewal pathways, which initiate
colon tumorigenesis. Our miR profiling studies to identify miRs that regulate
colon cancer stem cells (CSCs) were broadly divided in two parts. In one study we profiled the normal crypt bottom subsection that is enriched in stem cells and identified miR23b to be one of the miRs to have a significant differential expression. MiR23b has already been identified as having a role in renal, prostate, bladder, breast and
colon cancers involving cell migration, invasion and apoptosis. Recently, a role for miR23b in ovarian CSCs and response to chemotherapy has also been elucidated. Consequently, I postulated that miR23b regulates
colon CSCs. My results showed that miR23b is overexpressed in the ALDEFLUOR high sub-population of HT29 and SW480
colon cancer cells. It was shown to control the
colon CSC phenotype and significantly affects proliferation, cell cycle, self-renewal, EMT, invasion and chemoresistance to the anti-cancer drug 5- FU. I validated that the
colon CSC marker LGR5 is a target of miR23b, showing its role in modulating Wnt signaling. MiR23b also influences the transcription of multiple gene targets such as ATF2 and AKT2, which were identified by our extensive RNA SEQ analysis. The other aspect of the study was to identify miRs, which are differentially expressed in the CSCs as compared to the normal SCs from fresh patient samples. Normal and tumor tissue were initially screened for the expression of multiple putative CSC markers (ALDH1, LRIG1, CD166, ABCG2, BMI1, Telomerase) with an aim to decide which markers should be used alone or in combination to isolate SCs. My results indicated for the first time that SC markers ALDH1, LRIG1 and CD166 do not co-stain cells in tumors suggesting a co-existence of subpopulations of CSCs in tumor. MiR profiling identified miRs such as miR200c, miR92a, miR20a and miR93 that had a significant differential expression in ALDEFLUOR high tumor cells as compared to ALDEFLUOR high normal cells. MiR92a was also significantly upregulated in ALDEFLUOR high cells of
colon cancer cell lines HT29 and regulated its proliferation. Future studies have to be done on the other newly recognized candidate miRs that show differential expression in primary tumor SCs. Understanding the role of miRs in CSCs could contribute to identification of new targets for therapeutic intervention.
Advisors/Committee Members: Boman, BruceGalileo, Deni S..
Subjects/Keywords: RNA.; Colon (Anatomy) – Cancer.; Carcinogenesis
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APA (6th Edition):
Viswanathan, V. (2014). MicroRNAs in normal and malignant colon stem cells and their possible role in stem cell origin of colon cancer. (Doctoral Dissertation). University of Delaware. Retrieved from http://udspace.udel.edu/handle/19716/16788
Chicago Manual of Style (16th Edition):
Viswanathan, Vignesh. “MicroRNAs in normal and malignant colon stem cells and their possible role in stem cell origin of colon cancer.” 2014. Doctoral Dissertation, University of Delaware. Accessed March 07, 2021.
http://udspace.udel.edu/handle/19716/16788.
MLA Handbook (7th Edition):
Viswanathan, Vignesh. “MicroRNAs in normal and malignant colon stem cells and their possible role in stem cell origin of colon cancer.” 2014. Web. 07 Mar 2021.
Vancouver:
Viswanathan V. MicroRNAs in normal and malignant colon stem cells and their possible role in stem cell origin of colon cancer. [Internet] [Doctoral dissertation]. University of Delaware; 2014. [cited 2021 Mar 07].
Available from: http://udspace.udel.edu/handle/19716/16788.
Council of Science Editors:
Viswanathan V. MicroRNAs in normal and malignant colon stem cells and their possible role in stem cell origin of colon cancer. [Doctoral Dissertation]. University of Delaware; 2014. Available from: http://udspace.udel.edu/handle/19716/16788
Universidad de Chile
28.
Torres Martínez, Verónica Fabiola.
Papel de mastocitos en la inducción de Bcl-3 y las alteraciones de la unión estrecha epitelial intestinal en el Síndrome de intestino irritable.
Degree: 2018, Universidad de Chile
URL: http://repositorio.uchile.cl/handle/2250/170117
► El síndrome de intestino irritable (SII) es un trastorno funcional digestivo caracterizado por la presencia de dolor abdominal asociado a alteraciones del hábito intestinal. Si…
(more)
▼ El síndrome de intestino irritable (SII) es un trastorno funcional digestivo
caracterizado por la presencia de dolor abdominal asociado a alteraciones del hábito
intestinal. Si bien su fisiopatología no ha sido dilucidada completamente, se reconoce la
existencia de un desequilibrio del eje cerebro-intestino, que afecta diversas funciones
intestinales, entre ellas el aumento de la permeabilidad paracelular y la activación de
células inmunes. La elevada activación de mastocitos se asocia a aumento de la
permeabilidad intestinal debido a alteraciones en la organización de la unión estrecha (UE),
mecanismo mediado por la activación de PAR-2 (receptor activado por proteasa-2) por
triptasa. La proteína inmuno-moduladora Bcl-3 (B-cell leukemia/lymphoma-3) es un
regulador transcripcional de genes activados por NF-κB, entre ellos los que regulan la UE.
En este trabajo se proponen las siguientes hipótesis: 1) En pacientes con SII, existe una
pérdida de la función de barrera intestinal asociada a un aumento en la expresión de Bcl-
3, a una elevada activación de mastocitos y a alteraciones de la unión estrecha epitelial; 2)
La expresión de Bcl-3, es inducida por triptasa, mediante la activación de PAR-2,
afectando el estado de la unión estrecha en líneas celulares de epitelio intestinal. Para ello,
muestras de mucosa ileal y colónica de pacientes con SII y SC (sujetos controles) fueron
recolectadas. En ellas se evaluó la expresión de Bcl-3, mediante q-PCR, western blot e
inmunofluorescencia indirecta (IFI); el número de mastocitos y su grado de activación, por
IFI y microscopía electrónica de transmisión (TEM); y las alteraciones de la UE, mediante
IFI y TEM. El efecto de triptasa sobre la expresión de Bcl-3 y las alteraciones en la UE
fueron evaluadas in vitro, en líneas celulares DLD-1 y Caco-2, mediante western blot e IFI.
Los resultados evidenciaron una elevada expresión de Bcl-3 un aumento en el número y
actividad de mastocitos, alteraciones en la distribución y expresión de ZO-1 en mucosa y
alteración de la arquitectura de la UE epitelial intestinal en pacientes con SII en
comparación con SC. Nuestros resultados in vitro evidenciaron que la expresión de Bcl-3
fue inducida por triptasa, a través de la activación de PAR-2, induciendo este estimulo
alteraciones en la distribución de proteínas de la UE. Nuestros hallazgos sugieren que en el
SII, la proteína Bcl-3 actuaría como un factor intermediario de las alteraciones de la UE
epitelial inducida por la activación de triptasa/PAR-2. Futuros estudios dirigidos estudiar
con profundidad este mecanismo permitirán contribuir a la fisiopatología del SII, en miras
de un nuevo marcador diagnostico y blanco terapéutico; Irritable bowel syndrome (IBS) is a digestive functional disorder characterized by the
presence of abdominal pain associated with alterations of the intestinal habit. Although its
pathophysiology has not been fully elucidated, the existence of an imbalance of the brainintestine
axis is recognized, which affects various intestinal…
Subjects/Keywords: Mastocitosis; Protooncogenes; Colon irritable
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APA (6th Edition):
Torres Martínez, V. F. (2018). Papel de mastocitos en la inducción de Bcl-3 y las alteraciones de la unión estrecha epitelial intestinal en el Síndrome de intestino irritable. (Thesis). Universidad de Chile. Retrieved from http://repositorio.uchile.cl/handle/2250/170117
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Torres Martínez, Verónica Fabiola. “Papel de mastocitos en la inducción de Bcl-3 y las alteraciones de la unión estrecha epitelial intestinal en el Síndrome de intestino irritable.” 2018. Thesis, Universidad de Chile. Accessed March 07, 2021.
http://repositorio.uchile.cl/handle/2250/170117.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Torres Martínez, Verónica Fabiola. “Papel de mastocitos en la inducción de Bcl-3 y las alteraciones de la unión estrecha epitelial intestinal en el Síndrome de intestino irritable.” 2018. Web. 07 Mar 2021.
Vancouver:
Torres Martínez VF. Papel de mastocitos en la inducción de Bcl-3 y las alteraciones de la unión estrecha epitelial intestinal en el Síndrome de intestino irritable. [Internet] [Thesis]. Universidad de Chile; 2018. [cited 2021 Mar 07].
Available from: http://repositorio.uchile.cl/handle/2250/170117.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Torres Martínez VF. Papel de mastocitos en la inducción de Bcl-3 y las alteraciones de la unión estrecha epitelial intestinal en el Síndrome de intestino irritable. [Thesis]. Universidad de Chile; 2018. Available from: http://repositorio.uchile.cl/handle/2250/170117
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
29.
Fiatte, Cathy.
Impact des agonistes de PPARy sur l'adhérence et la migration des cellules colorectales humaines HT29 : Impact of PPAR gamma agonists on adhesion and migration of coton adenocarcinoma HT29 cells.
Degree: Docteur es, Biochimie, 2008, Metz
URL: http://www.theses.fr/2008METZ028S
► Les récepteurs activables par les proliférateurs de peroxysomes appartiennent à la superfamille des récepteurs nucléaires aux hormones. Trois isotypes de PPAR ont été identifiés¡: PPAR,…
(more)
▼ Les récepteurs activables par les proliférateurs de peroxysomes appartiennent à la superfamille des récepteurs nucléaires aux hormones. Trois isotypes de PPAR ont été identifiés¡: PPAR, PPAR et PPAR. Les PPAR sont impliqués dans la régulation du métabolisme lipidique, dans l homéostasie du glucose, la prolifération cellulaire et dans la réponse inflammatoire. Ils interviennent également dans la carcinogenèse colique et/ou la progression tumorale. Nous avons étudié l effet de l activation de PPAR et par les thiazolidinediones et les fibrates, respectivement, sur l adhérence et la migration de la lignée HT29 dérivant d adénocarcinome colique humain. Nos résultats montrent que les thiazolidinediones et le fénofibrate modifient l expression de gènes impliqués dans l adhérence et la migration des cellules HT29, en particulier lorsqu elles sont exposées de façon chronique. Un traitement long, quel que soit l agoniste, induit l expression de l intégrine 5. La modification de l expression des molécules d adhérence par les thiazolidinediones est, au moins en partie, due à un mécanisme PPAR -dépendant, et l ensemble des effets observés diffèrent selon le temps de traitement, la dose et la nature du ligand. In vivo, les thiazolidinediones inhibent la formation de métastases à distance et diminuent le volume tumoral. Administrée en prévention, la pioglitazone abolit la formation des tumeurs et métastases. Avec la même approche expérimentale, des résultats comparables sont obtenus en utilisant le fénofibrate, ligand de PPAR . En conclusion, un traitement par les agonistes de PPARg et pourrait être intéressant pour l amélioration des traitements actuels du cancer du colon.
Peroxisome proliferator-activated receptors (PPAR) belong to the nuclear hormone receptor family. Three isotypes, encoded by separate genes, have been identified: PPAR, PPAR and PPAR. They are involved in lipid metabolism, glucose homeostasis, cell proliferation and differentiation, and inflammatory response. They have also been implicated in colon carcinogenesis and/or tumour progression. We studied the effect of PPARg and activation by thiazolidinediones and fibrates, respectively, on adhesion and migration of colon adenocarcinoma HT29 cell line. Exposure to thiazolidinedione modifies expression of several genes involved in HT29 cell adhesion and migration, especially when cells are chronically treated with each drug. Of interest, long cell treatment either with pioglitazone, rosiglitazone or fenofibrate induced expression of integrin 5-chain. Our results suggest that the modulation of adhesion molecule expression by thiazolidinediones is partly through PPARg-dependent activation and that effects are different according to the dose and nature of ligand. In vivo, thiazolidinediones especially inhibit distant metastasis formation and diminish tumoral growth. In prevention, pioglitazone abolish tumoral and metastasis development. Using the same experimental approach, we demonstrated that fenofibrate as a ligand of PPAR raised similar results. Collectively, we…
Advisors/Committee Members: Bagrel, Denyse (thesis director), Schohn, Nicolas (thesis director).
Subjects/Keywords: Ppar; Colon
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❌
APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Fiatte, C. (2008). Impact des agonistes de PPARy sur l'adhérence et la migration des cellules colorectales humaines HT29 : Impact of PPAR gamma agonists on adhesion and migration of coton adenocarcinoma HT29 cells. (Doctoral Dissertation). Metz. Retrieved from http://www.theses.fr/2008METZ028S
Chicago Manual of Style (16th Edition):
Fiatte, Cathy. “Impact des agonistes de PPARy sur l'adhérence et la migration des cellules colorectales humaines HT29 : Impact of PPAR gamma agonists on adhesion and migration of coton adenocarcinoma HT29 cells.” 2008. Doctoral Dissertation, Metz. Accessed March 07, 2021.
http://www.theses.fr/2008METZ028S.
MLA Handbook (7th Edition):
Fiatte, Cathy. “Impact des agonistes de PPARy sur l'adhérence et la migration des cellules colorectales humaines HT29 : Impact of PPAR gamma agonists on adhesion and migration of coton adenocarcinoma HT29 cells.” 2008. Web. 07 Mar 2021.
Vancouver:
Fiatte C. Impact des agonistes de PPARy sur l'adhérence et la migration des cellules colorectales humaines HT29 : Impact of PPAR gamma agonists on adhesion and migration of coton adenocarcinoma HT29 cells. [Internet] [Doctoral dissertation]. Metz; 2008. [cited 2021 Mar 07].
Available from: http://www.theses.fr/2008METZ028S.
Council of Science Editors:
Fiatte C. Impact des agonistes de PPARy sur l'adhérence et la migration des cellules colorectales humaines HT29 : Impact of PPAR gamma agonists on adhesion and migration of coton adenocarcinoma HT29 cells. [Doctoral Dissertation]. Metz; 2008. Available from: http://www.theses.fr/2008METZ028S
30.
上藤,聖子.
Protein-bound Polysaccharide K Reduced the Invasive Ability of Colon Cancer Cell Lines : PSKは大腸癌細胞株の浸潤能を低下させる.
Degree: 博士(医学), 2014, University of Fukui / 福井大学
URL: http://hdl.handle.net/10098/8445
以下に掲載 : Anticancer Research 33(11) 4841-4845 2013. International Institute of Ancicancer Research. 共著者 : Seiko Uwafuji, Takanori Goi, Takayuki Naruse, Hidetaka Kurebayashi, Toshiyuki Nakazawa, Hirono Yasuo, Akio Yamaguchi
Subjects/Keywords: Colon cancer; polysaccharide K; invasion
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APA ·
Chicago ·
MLA ·
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CSE |
Export
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APA (6th Edition):
上藤,聖子. (2014). Protein-bound Polysaccharide K Reduced the Invasive Ability of Colon Cancer Cell Lines : PSKは大腸癌細胞株の浸潤能を低下させる. (Thesis). University of Fukui / 福井大学. Retrieved from http://hdl.handle.net/10098/8445
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
上藤,聖子. “Protein-bound Polysaccharide K Reduced the Invasive Ability of Colon Cancer Cell Lines : PSKは大腸癌細胞株の浸潤能を低下させる.” 2014. Thesis, University of Fukui / 福井大学. Accessed March 07, 2021.
http://hdl.handle.net/10098/8445.
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
上藤,聖子. “Protein-bound Polysaccharide K Reduced the Invasive Ability of Colon Cancer Cell Lines : PSKは大腸癌細胞株の浸潤能を低下させる.” 2014. Web. 07 Mar 2021.
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Vancouver:
上藤,聖子. Protein-bound Polysaccharide K Reduced the Invasive Ability of Colon Cancer Cell Lines : PSKは大腸癌細胞株の浸潤能を低下させる. [Internet] [Thesis]. University of Fukui / 福井大学; 2014. [cited 2021 Mar 07].
Available from: http://hdl.handle.net/10098/8445.
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
上藤,聖子. Protein-bound Polysaccharide K Reduced the Invasive Ability of Colon Cancer Cell Lines : PSKは大腸癌細胞株の浸潤能を低下させる. [Thesis]. University of Fukui / 福井大学; 2014. Available from: http://hdl.handle.net/10098/8445
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation
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Open Access Theses and Dissertations