subject:(colon)

1. Gómez de las Heras, Cristina. Papel de la colonografía por tomografía computerizada en el carcinoma colorrectal.

Degree: 2014, Universidad de Sevilla

► El cáncer colorrectal (CCR) es una de las neoplasias más frecuentes en los países occidentales, siendo la segunda neoplasia más frecuente en ambos sexos en… (more)

Subjects/Keywords: Colon

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APA (6^th Edition):

Gómez de las Heras, C. (2014). Papel de la colonografía por tomografía computerizada en el carcinoma colorrectal. (Thesis). Universidad de Sevilla. Retrieved from http://hdl.handle.net/11441/24128

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gómez de las Heras, Cristina. “Papel de la colonografía por tomografía computerizada en el carcinoma colorrectal.” 2014. Thesis, Universidad de Sevilla. Accessed November 16, 2018. http://hdl.handle.net/11441/24128.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gómez de las Heras, Cristina. “Papel de la colonografía por tomografía computerizada en el carcinoma colorrectal.” 2014. Web. 16 Nov 2018.

Vancouver:

Gómez de las Heras C. Papel de la colonografía por tomografía computerizada en el carcinoma colorrectal. [Internet] [Thesis]. Universidad de Sevilla; 2014. [cited 2018 Nov 16]. Available from: http://hdl.handle.net/11441/24128.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gómez de las Heras C. Papel de la colonografía por tomografía computerizada en el carcinoma colorrectal. [Thesis]. Universidad de Sevilla; 2014. Available from: http://hdl.handle.net/11441/24128

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Georgia

2. Niecko, Timothy Edward. A pharmacoepidemiologic assessment of nonsteroidal anti-inflammatory drug exposure and the association withcolorectal cancer, gastrointestinal and renal adverse events.

Degree: MS, Pharmacy, 2001, University of Georgia

URL: http://purl.galileo.usg.edu/uga_etd/niecko_timothy_e_200112_ms

► INTRODUCTION: Colorectal cancer (CRC) is the second leading cause of cancer-related deaths and is a growing health concern. Recently, epidemiological studies have associated NSAID use… (more)

Subjects/Keywords: Colon

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APA (6^th Edition):

Niecko, T. E. (2001). A pharmacoepidemiologic assessment of nonsteroidal anti-inflammatory drug exposure and the association withcolorectal cancer, gastrointestinal and renal adverse events. (Masters Thesis). University of Georgia. Retrieved from http://purl.galileo.usg.edu/uga_etd/niecko_timothy_e_200112_ms

Chicago Manual of Style (16^th Edition):

Niecko, Timothy Edward. “A pharmacoepidemiologic assessment of nonsteroidal anti-inflammatory drug exposure and the association withcolorectal cancer, gastrointestinal and renal adverse events.” 2001. Masters Thesis, University of Georgia. Accessed November 16, 2018. http://purl.galileo.usg.edu/uga_etd/niecko_timothy_e_200112_ms.

MLA Handbook (7^th Edition):

Niecko, Timothy Edward. “A pharmacoepidemiologic assessment of nonsteroidal anti-inflammatory drug exposure and the association withcolorectal cancer, gastrointestinal and renal adverse events.” 2001. Web. 16 Nov 2018.

Vancouver:

Niecko TE. A pharmacoepidemiologic assessment of nonsteroidal anti-inflammatory drug exposure and the association withcolorectal cancer, gastrointestinal and renal adverse events. [Internet] [Masters thesis]. University of Georgia; 2001. [cited 2018 Nov 16]. Available from: http://purl.galileo.usg.edu/uga_etd/niecko_timothy_e_200112_ms.

Council of Science Editors:

Niecko TE. A pharmacoepidemiologic assessment of nonsteroidal anti-inflammatory drug exposure and the association withcolorectal cancer, gastrointestinal and renal adverse events. [Masters Thesis]. University of Georgia; 2001. Available from: http://purl.galileo.usg.edu/uga_etd/niecko_timothy_e_200112_ms

3. Armstrong, Cameron Michelle. The Protective Effects of Estradiol on Sporadic and Inflammation-associated Colon Cancer.

Degree: 2013, Texas Digital Library

URL: http://hdl.handle.net/1969; http://hdl.handle.net/2249.1/66776

► Epidemiological studies suggest pre-menopausal women have a reduced risk for sporadic and inflammation-associated colon cancer compared to post-menopausal women and men. The studies presented herein… (more)

▼ Epidemiological studies suggest pre-menopausal women have a reduced risk for sporadic and inflammation-associated colon cancer compared to post-menopausal women and men. The studies presented herein aim to determine the protective mechanisms of estradiol (E2) during sporadic and inflammation-associated colonic carcinogenesis. When investigating the role of E2 and fish oil at the earliest stage of sporadic colon cancer development, E2 had no effect on DNA adduct formation while dietary fish oil significantly reduced DNA adduct formation. Contrarily, E2 significantly induced apoptosis of damaged colonocytes while fish oil was not protective. In an in vivo model of inflammation-associated colon carcinogenesis with E2 administered following induction of DNA damage and initiation of inflammation, E2 treatment was associated with decreased colon tumor size and number in wild type (WT) but not estrogen receptor (ER) ?? knockout (ER??KO) mice. Interestingly, apoptosis was reduced and proliferation increased by E2 in these tumors in WT mice. This may be due to the altered ER expression in these tissues as the tumors developed, with ER????expression decreasing concomitantly with ER?? expression increasing. Contrary to the protective effect of E2 on inflammation-associated colon tumor formation, which was dependent on ER??, during acute inflammation in the colon E2 was protective against inflammation in both WT and ER??KO mice and injury in ER??KO mice. The protection against inflammation is likely due to the reduction of pro-inflammatory cytokine expression by E2. Apoptosis and proliferation were decreased and increased in the proximal and distal colon respectively in ER??KO mice. In vitro studies further elucidated the roles of ER?? and ER?? in colonocytes. E2 and ER??, but not ER??, specific agonists reduced cell number and induce apoptosis in nonmalignant colonocytes. This effect was lost in the presence of mutated p53. In ER?? overexpressed nonmalignant colonocytes, E2 had no effect on cell number while ER?? agonist and ER?? agonists decreased and increased cell number respectively. These studies suggest that E2 is protective in the colon and ER?? is required for protection against carcinogenesis but not protection against inflammation. Additionally, the protection against colon carcinogenesis is likely p53 mediated. Advisors/Committee Members: Allred, Clinton D (advisor).

Subjects/Keywords: colon cancer

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APA (6^th Edition):

Armstrong, C. M. (2013). The Protective Effects of Estradiol on Sporadic and Inflammation-associated Colon Cancer. (Thesis). Texas Digital Library. Retrieved from http://hdl.handle.net/1969; http://hdl.handle.net/2249.1/66776

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Armstrong, Cameron Michelle. “The Protective Effects of Estradiol on Sporadic and Inflammation-associated Colon Cancer.” 2013. Thesis, Texas Digital Library. Accessed November 16, 2018. http://hdl.handle.net/1969; http://hdl.handle.net/2249.1/66776.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Armstrong, Cameron Michelle. “The Protective Effects of Estradiol on Sporadic and Inflammation-associated Colon Cancer.” 2013. Web. 16 Nov 2018.

Vancouver:

Armstrong CM. The Protective Effects of Estradiol on Sporadic and Inflammation-associated Colon Cancer. [Internet] [Thesis]. Texas Digital Library; 2013. [cited 2018 Nov 16]. Available from: http://hdl.handle.net/1969; http://hdl.handle.net/2249.1/66776.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Armstrong CM. The Protective Effects of Estradiol on Sporadic and Inflammation-associated Colon Cancer. [Thesis]. Texas Digital Library; 2013. Available from: http://hdl.handle.net/1969; http://hdl.handle.net/2249.1/66776

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

4. Fiatte, Cathy. Impact des agonistes de PPARy sur l'adhérence et la migration des cellules colorectales humaines HT29 : Impact of PPAR gamma agonists on adhesion and migration of coton adenocarcinoma HT29 cells.

Degree: Docteur es, Biochimie, 2008, Metz

URL: http://www.theses.fr/2008METZ028S

►

Les récepteurs activables par les proliférateurs de peroxysomes appartiennent à la superfamille des récepteurs nucléaires aux hormones. Trois isotypes de PPAR ont été identifiés¡: PPAR,… (more)

▼

Les récepteurs activables par les proliférateurs de peroxysomes appartiennent à la superfamille des récepteurs nucléaires aux hormones. Trois isotypes de PPAR ont été identifiés¡: PPAR, PPAR et PPAR. Les PPAR sont impliqués dans la régulation du métabolisme lipidique, dans l homéostasie du glucose, la prolifération cellulaire et dans la réponse inflammatoire. Ils interviennent également dans la carcinogenèse colique et/ou la progression tumorale. Nous avons étudié l effet de l activation de PPAR et par les thiazolidinediones et les fibrates, respectivement, sur l adhérence et la migration de la lignée HT29 dérivant d adénocarcinome colique humain. Nos résultats montrent que les thiazolidinediones et le fénofibrate modifient l expression de gènes impliqués dans l adhérence et la migration des cellules HT29, en particulier lorsqu elles sont exposées de façon chronique. Un traitement long, quel que soit l agoniste, induit l expression de l intégrine 5. La modification de l expression des molécules d adhérence par les thiazolidinediones est, au moins en partie, due à un mécanisme PPAR -dépendant, et l ensemble des effets observés diffèrent selon le temps de traitement, la dose et la nature du ligand. In vivo, les thiazolidinediones inhibent la formation de métastases à distance et diminuent le volume tumoral. Administrée en prévention, la pioglitazone abolit la formation des tumeurs et métastases. Avec la même approche expérimentale, des résultats comparables sont obtenus en utilisant le fénofibrate, ligand de PPAR . En conclusion, un traitement par les agonistes de PPARg et pourrait être intéressant pour l amélioration des traitements actuels du cancer du colon.

Peroxisome proliferator-activated receptors (PPAR) belong to the nuclear hormone receptor family. Three isotypes, encoded by separate genes, have been identified: PPAR, PPAR and PPAR. They are involved in lipid metabolism, glucose homeostasis, cell proliferation and differentiation, and inflammatory response. They have also been implicated in colon carcinogenesis and/or tumour progression. We studied the effect of PPARg and activation by thiazolidinediones and fibrates, respectively, on adhesion and migration of colon adenocarcinoma HT29 cell line. Exposure to thiazolidinedione modifies expression of several genes involved in HT29 cell adhesion and migration, especially when cells are chronically treated with each drug. Of interest, long cell treatment either with pioglitazone, rosiglitazone or fenofibrate induced expression of integrin 5-chain. Our results suggest that the modulation of adhesion molecule expression by thiazolidinediones is partly through PPARg-dependent activation and that effects are different according to the dose and nature of ligand. In vivo, thiazolidinediones especially inhibit distant metastasis formation and diminish tumoral growth. In prevention, pioglitazone abolish tumoral and metastasis development. Using the same experimental approach, we demonstrated that fenofibrate as a ligand of PPAR raised similar results. Collectively, we…

Advisors/Committee Members: Bagrel, Denyse (thesis director), Schohn, Nicolas (thesis director).

Subjects/Keywords: Ppar; Colon

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APA (6^th Edition):

Fiatte, C. (2008). Impact des agonistes de PPARy sur l'adhérence et la migration des cellules colorectales humaines HT29 : Impact of PPAR gamma agonists on adhesion and migration of coton adenocarcinoma HT29 cells. (Doctoral Dissertation). Metz. Retrieved from http://www.theses.fr/2008METZ028S

Chicago Manual of Style (16^th Edition):

Fiatte, Cathy. “Impact des agonistes de PPARy sur l'adhérence et la migration des cellules colorectales humaines HT29 : Impact of PPAR gamma agonists on adhesion and migration of coton adenocarcinoma HT29 cells.” 2008. Doctoral Dissertation, Metz. Accessed November 16, 2018. http://www.theses.fr/2008METZ028S.

MLA Handbook (7^th Edition):

Fiatte, Cathy. “Impact des agonistes de PPARy sur l'adhérence et la migration des cellules colorectales humaines HT29 : Impact of PPAR gamma agonists on adhesion and migration of coton adenocarcinoma HT29 cells.” 2008. Web. 16 Nov 2018.

Vancouver:

Fiatte C. Impact des agonistes de PPARy sur l'adhérence et la migration des cellules colorectales humaines HT29 : Impact of PPAR gamma agonists on adhesion and migration of coton adenocarcinoma HT29 cells. [Internet] [Doctoral dissertation]. Metz; 2008. [cited 2018 Nov 16]. Available from: http://www.theses.fr/2008METZ028S.

Council of Science Editors:

Fiatte C. Impact des agonistes de PPARy sur l'adhérence et la migration des cellules colorectales humaines HT29 : Impact of PPAR gamma agonists on adhesion and migration of coton adenocarcinoma HT29 cells. [Doctoral Dissertation]. Metz; 2008. Available from: http://www.theses.fr/2008METZ028S

University of Manitoba

5. Blanchard, Audrey-Ann Marie. Gross assessment of colonic abnormalities with particular focus on diverticular disease and polyps: an autopsy study.

Degree: Pathology, 2007, University of Manitoba

URL: http://hdl.handle.net/1993/2756

► I-Abstract I.1-Objectives- To grossly evaluate colonic abnormalities within the Manitoba population by determining prevalence according to; age, gender, body mass index, body weight, body length,… (more)

Subjects/Keywords: colon

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APA (6^th Edition):

Blanchard, A. M. (2007). Gross assessment of colonic abnormalities with particular focus on diverticular disease and polyps: an autopsy study. (Masters Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/2756

Chicago Manual of Style (16^th Edition):

Blanchard, Audrey-Ann Marie. “Gross assessment of colonic abnormalities with particular focus on diverticular disease and polyps: an autopsy study.” 2007. Masters Thesis, University of Manitoba. Accessed November 16, 2018. http://hdl.handle.net/1993/2756.

MLA Handbook (7^th Edition):

Blanchard, Audrey-Ann Marie. “Gross assessment of colonic abnormalities with particular focus on diverticular disease and polyps: an autopsy study.” 2007. Web. 16 Nov 2018.

Vancouver:

Blanchard AM. Gross assessment of colonic abnormalities with particular focus on diverticular disease and polyps: an autopsy study. [Internet] [Masters thesis]. University of Manitoba; 2007. [cited 2018 Nov 16]. Available from: http://hdl.handle.net/1993/2756.

Council of Science Editors:

Blanchard AM. Gross assessment of colonic abnormalities with particular focus on diverticular disease and polyps: an autopsy study. [Masters Thesis]. University of Manitoba; 2007. Available from: http://hdl.handle.net/1993/2756

6. Fabrizi, Eros. Identification of novel therapeutic targets for colon adenocarcinoma.

Degree: 2011, Università degli Studi di Catania

URL: http://hdl.handle.net/10761/95

► Colorectal cancer (CRC) is the third most common form of cancer in the Western world. Despite the emergence of new targeted agents and the use… (more)

▼ Colorectal cancer (CRC) is the third most common form of cancer in the Western world. Despite the emergence of new targeted agents and the use of various therapeutic combinations, none of the treatment options available is curative in patients with advanced cancer. A growing body of evidence is increasingly supporting the idea that malignancies originate from a small fraction of cancer cells, called Cancer Stem Cells (CSC), that show self-renewal and pluripotency and are capable of initiating and sustaining tumor growth. Several studies have shown that, with respect to the bulk of tumor cells, CSC posses a higher degree of resistance to chemotherapy and radiotherapy that could explain the inefficacy of current therapies. The ability to isolate and study these tumor cells provided a powerful tool for the investigation of drug-and radio-resistance mechanisms thus paving the way for the development of novel targeted therapies aimed at the tumor complete eradication. The aim of this PhD thesis was to use CSC lines, derived from CRC specimens, to individuate new potential molecular targets for the development of novel therapies. To this end four colon-CSC lines were subjected to phosphoproteomic analysis by RPPA (Reverse Phase Protein Array) technology. Through this analysis phosphorylation levels of various protein kinases and their substrates were evaluated in order to create an activation map of the main colon-CSC proliferation and cell survival pathways. In parallel colon-CSC lines have been screened in vitro to the action of 80 commercially available protein-kinase inhibitors. This screening has revealed a partial correlation between in vitro sensitivity and phosphoproteomic analysis, but in this study, was not possible to identify predictive factors to infer colon-CSC sensitivity to specific kinase inhibitors. Colon-CSC was sensitive to the inhibition of protein kinase C (PKC), known regulator of cell proliferation and survival. Among PKC inhibitors, the most interesting was the UCN-01, a staurosporine derivative that can also inhibit PDK1 and Chk1. This compound has been already used in clinical trials as antineoplastic agent in combination with conventional chemotherapy. The in vitro treatment of colon-CSC with UCN-01 has demonstrated its ability to enhance the irinotecan cytotoxicity by increasing the apoptotic response. The combined action of UCN-01 and irinotecan caused a marked reduction in the levels of antiapoptotic proteins such as Bcl-XL and Mcl-1 and the activation of caspase 3. The in vivo administration of UCN-01/irinotecan combination, in a mouse model of subcutaneous xenograft, confirmed the observations obtained in vitro, leading to a significant reduction in tumor growth compared to the single treatments. UCN-01 has also shown efficacy in the inhibition of Chk1, as demonstrated by the reduction of the phosphorylation of its target protein cdc25. Inhibition of Chk1, an important regulator of cell cycle, in combination with chemotherapy, could help in…

Subjects/Keywords: Colon cancer; Colon cancer stem cells

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APA (6^th Edition):

Fabrizi, E. (2011). Identification of novel therapeutic targets for colon adenocarcinoma. (Thesis). Università degli Studi di Catania. Retrieved from http://hdl.handle.net/10761/95

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Fabrizi, Eros. “Identification of novel therapeutic targets for colon adenocarcinoma.” 2011. Thesis, Università degli Studi di Catania. Accessed November 16, 2018. http://hdl.handle.net/10761/95.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Fabrizi, Eros. “Identification of novel therapeutic targets for colon adenocarcinoma.” 2011. Web. 16 Nov 2018.

Vancouver:

Fabrizi E. Identification of novel therapeutic targets for colon adenocarcinoma. [Internet] [Thesis]. Università degli Studi di Catania; 2011. [cited 2018 Nov 16]. Available from: http://hdl.handle.net/10761/95.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Fabrizi E. Identification of novel therapeutic targets for colon adenocarcinoma. [Thesis]. Università degli Studi di Catania; 2011. Available from: http://hdl.handle.net/10761/95

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

7. Arteaga Hernández, Allan Fernando. Manejo quirúrgico del cáncer de colón en el hospital Nacional dos de mayo.

Degree: 2013, National University of San Marcos

URL: http://cybertesis.unmsm.edu.pe/handle/cybertesis/3962 ; http://cybertesis.unmsm.edu.pe/bitstream/cybertesis%2F3962/2/bitstream ; http://cybertesis.unmsm.edu.pe/bitstream/cybertesis%2F3962/1/bitstream

► En el Perú, según estadísticas del año 2011, el cáncer constituye la segunda causa de muerte, sólo después de las enfermedades cardiovasculares. Asimismo, en nuestra… (more)

Subjects/Keywords: Colon (Anatomía) - Cirugía; Colon (Anatomía) - Cáncer - Diagnóstico

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APA (6^th Edition):

Arteaga Hernández, A. F. (2013). Manejo quirúrgico del cáncer de colón en el hospital Nacional dos de mayo. (Thesis). National University of San Marcos. Retrieved from http://cybertesis.unmsm.edu.pe/handle/cybertesis/3962 ; http://cybertesis.unmsm.edu.pe/bitstream/cybertesis%2F3962/2/bitstream ; http://cybertesis.unmsm.edu.pe/bitstream/cybertesis%2F3962/1/bitstream

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Arteaga Hernández, Allan Fernando. “Manejo quirúrgico del cáncer de colón en el hospital Nacional dos de mayo.” 2013. Thesis, National University of San Marcos. Accessed November 16, 2018. http://cybertesis.unmsm.edu.pe/handle/cybertesis/3962 ; http://cybertesis.unmsm.edu.pe/bitstream/cybertesis%2F3962/2/bitstream ; http://cybertesis.unmsm.edu.pe/bitstream/cybertesis%2F3962/1/bitstream.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Arteaga Hernández, Allan Fernando. “Manejo quirúrgico del cáncer de colón en el hospital Nacional dos de mayo.” 2013. Web. 16 Nov 2018.

Vancouver:

Arteaga Hernández AF. Manejo quirúrgico del cáncer de colón en el hospital Nacional dos de mayo. [Internet] [Thesis]. National University of San Marcos; 2013. [cited 2018 Nov 16]. Available from: http://cybertesis.unmsm.edu.pe/handle/cybertesis/3962 ; http://cybertesis.unmsm.edu.pe/bitstream/cybertesis%2F3962/2/bitstream ; http://cybertesis.unmsm.edu.pe/bitstream/cybertesis%2F3962/1/bitstream.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Arteaga Hernández AF. Manejo quirúrgico del cáncer de colón en el hospital Nacional dos de mayo. [Thesis]. National University of San Marcos; 2013. Available from: http://cybertesis.unmsm.edu.pe/handle/cybertesis/3962 ; http://cybertesis.unmsm.edu.pe/bitstream/cybertesis%2F3962/2/bitstream ; http://cybertesis.unmsm.edu.pe/bitstream/cybertesis%2F3962/1/bitstream

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

8. Routy, Bertrand. Contribution of Gut Microbiota on Systemic Response to Anticancer Immonumodulatory Agents : Rôle du microbiote intestinal dans l'éfficacité et la toxicité des thérapies anti-tumorales immunomodulatrice.

Degree: Docteur es, Aspects moléculaires et cellulaires de la biologie, 2017, Paris Saclay

URL: http://www.theses.fr/2017SACLS398

►

Les anticorps bloquant les rétrocontrôles inhibiteurs du système immunitaire (ICB) ont révolutionné la prise en charge des patients atteints de certains cancers. Les ICB bloquent… (more)

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Les anticorps bloquant les rétrocontrôles inhibiteurs du système immunitaire (ICB) ont révolutionné la prise en charge des patients atteints de certains cancers. Les ICB bloquent l’axe cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) ou programmed cell death protein 1/PD-L1-PD-L2 et permettent une réactivation des cellules T stimulant l’immunité anti-tumorale. Toutefois, malgré cette avancée plus de 70 % des patients finiront par progresser et ces traitements peuvent entrainer des toxicités de type auto-immunes sévères. Il est donc fondamental d’identifier des biomarqueurs prédictifs de la réponse clinique et ainsi développer une nouvelle stratégie thérapeutique efficace pour augmenter l’index thérapeutique des ICB. Plusieurs groupes ont participé à décrire le lien étroit entre le microbiote intestinal et la réponse à la chimiothérapie (cyclophosphamide), à la greffe allogénique ainsi qu’aux les thérapies immunomodulatrices (anti-CTLA4 and PD1 Abs). Mon travail de thèse vient à la suite de ces travaux princeps et a permis de montrer que la composition du microbiote intestinal est en partie responsable de l’activité anti-tumorale des ICB dans plusieurs cancers. L’analyse de 249 patients atteints d’un cancer métastatique du poumon, du rein et cancer urothelial traités par l’anti-PD-1 ou l’anti-PD-L1 les antibiotiques (ATB) diminuaient la survie sans progression (PFS) de 3.5 vs 4.1 mois (p=0.017) et la survie globale de 11.5 vs 20.6 mois (p<0.001) par rapport aux patients n’ayant pas pris d’ATB avant de débuter les ICB. Nous avons par la suite analysé par métagénomique les selles de 153 patients atteints d’un cancer du poumon et du rein traités par l’anti-PD-1. Les résultats ont montré que Akkermmansia muciniphila est plus abondante chez les patients ayant une meilleure réponse clinique et une meilleure PFS. De plus, nous avons démontré que la présence d’une réponse mémoire spécifique des cellules CD4+ ou CD8+ envers A. muciniphila est associée à une plus longue PFS. Par la suite, des transplantations de microbiote fécal (FMT) avec les selles de ces patients chez des souris axéniques ou traitées par ATB montrent que les selles des répondeurs à l’anti-PD-1 entrainent une forte réponse immunitaire anti-tumorale post anti-PD-1 comparé aux selles de non-répondeurs. De plus, un gavage oral avec A. muciniphila après la FMT avec des selles de non-répondeurs restaure une forte réponse immunitaire post anti-PD-1 via la production d’IL-12 par les cellules dendritiques entrainant l’augmentation du recrutement des cellules T CD4+CXCR3+CCR9+ du ganglion mésentérique vers le site tumoral et une augmentation du ratio CD4/Treg. L’ensemble de ces résultats suggèrent que la découverte de bactérie immunogène capable de prédire le bénéfice clinique des ICB permettra de développer une stratégie thérapeutique efficace afin d’augmenter la survie des patients atteints de cancer.Mots clés : ICB, anti-PD-1, anti-PDL-1, cancer du poumon, cancer du rein, microbiote intestinal

In oncology, a novel therapeutic era based on immune checkpoint…

Advisors/Committee Members: Zitvogel, Laurence (thesis director).

Subjects/Keywords: Immunologie; Microbiote; Colon; Immunology; Microbiota; Colon

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Routy, B. (2017). Contribution of Gut Microbiota on Systemic Response to Anticancer Immonumodulatory Agents : Rôle du microbiote intestinal dans l'éfficacité et la toxicité des thérapies anti-tumorales immunomodulatrice. (Doctoral Dissertation). Paris Saclay. Retrieved from http://www.theses.fr/2017SACLS398

Chicago Manual of Style (16^th Edition):

Routy, Bertrand. “Contribution of Gut Microbiota on Systemic Response to Anticancer Immonumodulatory Agents : Rôle du microbiote intestinal dans l'éfficacité et la toxicité des thérapies anti-tumorales immunomodulatrice.” 2017. Doctoral Dissertation, Paris Saclay. Accessed November 16, 2018. http://www.theses.fr/2017SACLS398.

MLA Handbook (7^th Edition):

Routy, Bertrand. “Contribution of Gut Microbiota on Systemic Response to Anticancer Immonumodulatory Agents : Rôle du microbiote intestinal dans l'éfficacité et la toxicité des thérapies anti-tumorales immunomodulatrice.” 2017. Web. 16 Nov 2018.

Vancouver:

Routy B. Contribution of Gut Microbiota on Systemic Response to Anticancer Immonumodulatory Agents : Rôle du microbiote intestinal dans l'éfficacité et la toxicité des thérapies anti-tumorales immunomodulatrice. [Internet] [Doctoral dissertation]. Paris Saclay; 2017. [cited 2018 Nov 16]. Available from: http://www.theses.fr/2017SACLS398.

Council of Science Editors:

Routy B. Contribution of Gut Microbiota on Systemic Response to Anticancer Immonumodulatory Agents : Rôle du microbiote intestinal dans l'éfficacité et la toxicité des thérapies anti-tumorales immunomodulatrice. [Doctoral Dissertation]. Paris Saclay; 2017. Available from: http://www.theses.fr/2017SACLS398

University of Utah

9. Andersen, Melissa. Role of MSH6 mutations in North American patients receiving clinical genetic testing for hereditary nonpolyposis colorectal cancer;.

Degree: MS;, Pathology;, 2007, University of Utah

URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1314/rec/1163

► The relationship of fibrinolytic activity produced by baby hamster kidney (BHK-21) cells to surface properties and growth of the cells has been studied. Hydrolysis of… (more)

▼ The relationship of fibrinolytic activity produced by baby hamster kidney (BHK-21) cells to surface properties and growth of the cells has been studied. Hydrolysis of fibrin clots and casein was used to detect cellular protease activity. Cloned, high passage sublines of the BHK-21/C13 cell line were found to produce increased fibrinolysis when compared to low passage BHK-21/C13 cells (C13). Low passage C13 cells were also found to produce an inhibitor of the cellular fibrinolysin. This inhibitory activity was detected when low and high protease-producing cell lines were co-cultivated and could be removed from the C13 cells by trypsin treatment. Inhibitor could again be detected in C13 cell cultures after 6-8.5 hours incubation at 37°C following typsinization. This substance was not detected in supernatant fluids from growing C13 cells and its production was inhibited by incubation of cells at 4°C. All high protease-producing cultures formed colonies in agar suspension, exhibited quantitative increases in agglutinability by concanavalin A (Con A) when compared to low passage cell cultures and grew faster as judged by transfer behavior of cells and increased rates of accumulation of cells in metaphase when grown in the presence of mitotic inhibitor. Low protease-producing C13 cells and sublines low in protease activity isolated from high passage cultures did not grow in agar suspension, exhibited slower growth rates and decreased agglutinability by Con A. Low protease-producing C13 cells could be stimulated to produce increase amounts of fibrinolytic activity with accompanying changes in surface properties characteristic of transformed cells by addition of purines such as hypoxanthine or adenosine to culture media. The effect was reversed by deletion of the purines. Growth of C13 cell in agar suspension did not occur with purine supplementation alone. With the addition of hypoxanthine and thymidine or adenosine and thymidine or adenosine and thymidine, C13 cells formed colonies in agar suspension which were similar to those formed by high protease-producing cell lines. Fibrinolytic activity could be detected from the colonies formed by C13 cells in agar suspension. Treatment of C13 cells suspended in agar with trypsin or fibrinolytically active culture fluids from high protease-producing cells did not result in the multiplication of the cells in agar. Temperature sensitive BHK-21 cells were isolated which were defective for cytokinesis but not karyokinesis. At 39-40°C these cells became enlarged and multinucleated. The defect did not appear to be associated with the cellular fibrinolysin because protease activity could be detected at the permissive and non-permissive temperatures. Growth of temperature sensitive cells in agar suspension did not occur at 39-40°C but cell enlargement, vacillation and lysis were observed in a large portion of the cell population. The data demonstrate that growth in agar suspension, increased Con A agglutinability and increased growth rates are positively associated in some way with the…

Subjects/Keywords: Colon Cancer; Genetics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Andersen, M. (2007). Role of MSH6 mutations in North American patients receiving clinical genetic testing for hereditary nonpolyposis colorectal cancer;. (Masters Thesis). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1314/rec/1163

Chicago Manual of Style (16^th Edition):

Andersen, Melissa. “Role of MSH6 mutations in North American patients receiving clinical genetic testing for hereditary nonpolyposis colorectal cancer;.” 2007. Masters Thesis, University of Utah. Accessed November 16, 2018. http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1314/rec/1163.

MLA Handbook (7^th Edition):

Andersen, Melissa. “Role of MSH6 mutations in North American patients receiving clinical genetic testing for hereditary nonpolyposis colorectal cancer;.” 2007. Web. 16 Nov 2018.

Vancouver:

Andersen M. Role of MSH6 mutations in North American patients receiving clinical genetic testing for hereditary nonpolyposis colorectal cancer;. [Internet] [Masters thesis]. University of Utah; 2007. [cited 2018 Nov 16]. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1314/rec/1163.

Council of Science Editors:

Andersen M. Role of MSH6 mutations in North American patients receiving clinical genetic testing for hereditary nonpolyposis colorectal cancer;. [Masters Thesis]. University of Utah; 2007. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1314/rec/1163

Universidad de Valladolid

10. Forero Torres, Augusto Alexander. Características epidemiológicas de la enfermedad diverticular del colon y de la diverticulitis aguda en Castilla y León. Aspectos sobre el tratamiento médico y quirúrgico.

Degree: 2016, Universidad de Valladolid

URL: http://uvadoc.uva.es/handle/10324/16848

► La enfermedad diverticular del colon es una de las enfermedades más prevalentes que afectan a la población occidental y por ende a la Comunidad Autónoma… (more)

▼ La enfermedad diverticular del colon es una de las enfermedades más prevalentes que afectan a la población occidental y por ende a la Comunidad Autónoma de Castilla y León. Es una patología relacionada con nuestro estilo de vida, con un aparente incremento estacional en los meses de verano y un amplio espectro de presentaciones clínicas con una tasa de mortalidad en pacientes intervenidos de urgencia que alcanza el 12% al 36%; genera estancias hospitalarias prolongadas y gastos no solo sanitarios sino de incapacidad, producidos por la presencia de un estoma. Se trata de un estudio observacional y descriptivo en la población mayor de edad hospitalizada en centros públicos de Sanidad de Castilla y León (SACYL) entre el 01 de enero de 2.001 y el 31 de diciembre de 2.013. La población de estudio está constituida por 12.689 casos, dados de alta con un diagnostico primario o secundario de diverticulitis y/o diverticulosis de colon. La base de datos utilizada fue el conjunto mínimo básico de datos (CMBD) y la clasificación se realizó teniendo en cuenta la clasificación internacional de enfermedades (CIE-9-MC) y los Grupos Relacionados por el Diagnóstico. Los resultados obtenidos nos permitieron llegar, entre otras, a las siguientes conclusiones: La hospitalización por enfermedad diverticular en Castilla y León presenta una tasa de 4,5 por 100.000 habitantes con un aumento progresivo en el periodo estudiado. La mortalidad global fue del 2,3% manteniéndose estable a lo largo del tiempo estudiado. Existe un incremento global de la enfermedad diverticular del colon, con un descenso de la diverticulitis grave, y un aumento de la diverticulitis leve. No encontramos la existencia de ritmo circanual. El tratamiento médico es 7 veces más frecuente que el quirúrgico en el total de altas de esta enfermedad. Encontramos un mayor porcentaje global de cirugías en los menores de 50 años. El tratamiento quirúrgico se asoció a las variables: edad, ingreso programado, ingresar tres o más veces e ingresar en un hospital general y de referencia. Existe una disminución global de la estancia, siendo el tratamiento quirúrgico el que genera una estancia hospitalaria más prolongada. La realización de una colostomía está relacionada con la edad e ingresar en dos o más ocasiones. Existe una tendencia ascendente en la realización de abordaje laparoscópico. Los ingresos que recibieron tratamiento quirúrgico, presentaron una mayor complejidad que los que recibieron tratamiento médico. Existe un descenso en la mortalidad de los pacientes quirúrgicos, siendo menor en el abordaje laparoscópico. La mortalidad se asoció a las variables: edad, realización de una intervención sobre el colon y realización de colostomía.

Subjects/Keywords: Colon (Anatomía) - Cirugía

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Forero Torres, A. A. (2016). Características epidemiológicas de la enfermedad diverticular del colon y de la diverticulitis aguda en Castilla y León. Aspectos sobre el tratamiento médico y quirúrgico. (Thesis). Universidad de Valladolid. Retrieved from http://uvadoc.uva.es/handle/10324/16848

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Forero Torres, Augusto Alexander. “Características epidemiológicas de la enfermedad diverticular del colon y de la diverticulitis aguda en Castilla y León. Aspectos sobre el tratamiento médico y quirúrgico.” 2016. Thesis, Universidad de Valladolid. Accessed November 16, 2018. http://uvadoc.uva.es/handle/10324/16848.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Forero Torres, Augusto Alexander. “Características epidemiológicas de la enfermedad diverticular del colon y de la diverticulitis aguda en Castilla y León. Aspectos sobre el tratamiento médico y quirúrgico.” 2016. Web. 16 Nov 2018.

Vancouver:

Forero Torres AA. Características epidemiológicas de la enfermedad diverticular del colon y de la diverticulitis aguda en Castilla y León. Aspectos sobre el tratamiento médico y quirúrgico. [Internet] [Thesis]. Universidad de Valladolid; 2016. [cited 2018 Nov 16]. Available from: http://uvadoc.uva.es/handle/10324/16848.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Forero Torres AA. Características epidemiológicas de la enfermedad diverticular del colon y de la diverticulitis aguda en Castilla y León. Aspectos sobre el tratamiento médico y quirúrgico. [Thesis]. Universidad de Valladolid; 2016. Available from: http://uvadoc.uva.es/handle/10324/16848

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidad de Valladolid

11. Moreno Racionero, Francisca. Importancia de la inmunidad perioperatoria en el diagnóstico de la infección intraabdominal tras la cirugía oncológica de colon.

Degree: 2017, Universidad de Valladolid

URL: http://uvadoc.uva.es/handle/10324/28656

► La fuga anastomótica, después de una colectomía, es una de las complicaciones más importantes en cirugía colorrectal, siendo el porcentaje de mortalidad un 10 %… (more)

Subjects/Keywords: Colon-Cáncer-Cirugía

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Moreno Racionero, F. (2017). Importancia de la inmunidad perioperatoria en el diagnóstico de la infección intraabdominal tras la cirugía oncológica de colon. (Thesis). Universidad de Valladolid. Retrieved from http://uvadoc.uva.es/handle/10324/28656

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Moreno Racionero, Francisca. “Importancia de la inmunidad perioperatoria en el diagnóstico de la infección intraabdominal tras la cirugía oncológica de colon.” 2017. Thesis, Universidad de Valladolid. Accessed November 16, 2018. http://uvadoc.uva.es/handle/10324/28656.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Moreno Racionero, Francisca. “Importancia de la inmunidad perioperatoria en el diagnóstico de la infección intraabdominal tras la cirugía oncológica de colon.” 2017. Web. 16 Nov 2018.

Vancouver:

Moreno Racionero F. Importancia de la inmunidad perioperatoria en el diagnóstico de la infección intraabdominal tras la cirugía oncológica de colon. [Internet] [Thesis]. Universidad de Valladolid; 2017. [cited 2018 Nov 16]. Available from: http://uvadoc.uva.es/handle/10324/28656.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Moreno Racionero F. Importancia de la inmunidad perioperatoria en el diagnóstico de la infección intraabdominal tras la cirugía oncológica de colon. [Thesis]. Universidad de Valladolid; 2017. Available from: http://uvadoc.uva.es/handle/10324/28656

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Aberdeen

12. Vase, Hollie Francesca. Interrogating therapeutic manipulation of the endocannabinoid system in the human colon.

Degree: PhD, 2013, University of Aberdeen

URL: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=203798 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.600095

► The endocannabinoid system (ECS) is known to be involved in key aspects of cell maintenance within the human colon, as well as being dysregulated in… (more)

▼ The endocannabinoid system (ECS) is known to be involved in key aspects of cell maintenance within the human colon, as well as being dysregulated in pathophysiological conditions, including colon inflammation and cancer. However, the contribution of the ECS within each of these conditions has not been fully elucidated. This indicates that the current identification of key targets within the ECS that are involved in gut pathology could be used as potential novel therapeutics. Two experimental approaches were designed and optimised to give an insight into ECS signal regulation within the human colon and to screen ECS therapeutics, tetrahydrocannabinol (THC) and cannabidiol (CBD); a human colon ex vivo explant culture model and an innovative multiplexed quantitative gene expression technology, the GenomeLab GeXP system (Beckman Coulter). Gene targets were identified that are known markers of regulation and function in cells of healthy tissue. An assay, the hCellMarkerPlex was designed that incorporated twenty-three of these gene targets, epithelial (EZR, KRT18, SLC9A2), proliferation (PCNA, CCND1, MS4A12), differentiation (B4GANLT2, CDX1, CDX2), apoptotic (CASP3, NOX1, NTN1), fibroblast (FSP1, COL1A1), structural (ACTG2, CNN1, DES), gene transcription (HDAC1), stem cell (LGR5), endothelial (VWF) and mucin production (MUC2). The hCellMarkerPlex identified gene signatures which distinguished between normal, adenoma and carcinoma tissue, identifying cellular processes showing abnormal activity associated with pathological status. The resulting biomarker profiles were used to establish a human colon explant culture system. The human colon explant culture presents a novel model to study modulation of the ECS and screen ECS therapeutics. Combined with the GenomeLab GeXP System multiple components of the ECS were assessed at the gene regulatory level. A custom designed GeXP assay, the hECSplex, was developed. hECSplex gene expression signatures of EC receptors (CNR1, CNR2, GPR55 and TRPV1), ECS enzymes (NAPE-PLD, GDE1, DAGLA, DAGLB, FAAH, FAAH2 and PTGS2), inflammatory (IL1B, IL10, IL6, LEP, TNF and SOCS3), signalling pathway (ID1, BCL2, CFL1, BIRC5, TP53, MYC and KRAS), lipid production (SREBF1, ACACA), and plasma-membrane (OCLN) markers revealed altered expression of ECS components in carcinogenesis compared to normal tissue. Abstract vi . The hECSplex gene expression signature of colon explants showed that ECS was not altered during culture, emphasising the explant models capability as a pharmaceutical tool to test current and novel therapeutics. Applications of both THC and CBD to normal colon explants at different concentrations do not lead to any significant changes. Indicating the current pharmacological use of phytocannabinoids is causing no adverse effects in surrounding healthy colon tissue. The GenomeLab System presents new opportunities to interrogate multiple components of the endocannabinoid signalling system in small colon explant tissue samples, and in response to ECS therapeutics.

Subjects/Keywords: 613.2; Colon (Anatomy)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Vase, H. F. (2013). Interrogating therapeutic manipulation of the endocannabinoid system in the human colon. (Doctoral Dissertation). University of Aberdeen. Retrieved from http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=203798 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.600095

Chicago Manual of Style (16^th Edition):

Vase, Hollie Francesca. “Interrogating therapeutic manipulation of the endocannabinoid system in the human colon.” 2013. Doctoral Dissertation, University of Aberdeen. Accessed November 16, 2018. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=203798 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.600095.

MLA Handbook (7^th Edition):

Vase, Hollie Francesca. “Interrogating therapeutic manipulation of the endocannabinoid system in the human colon.” 2013. Web. 16 Nov 2018.

Vancouver:

Vase HF. Interrogating therapeutic manipulation of the endocannabinoid system in the human colon. [Internet] [Doctoral dissertation]. University of Aberdeen; 2013. [cited 2018 Nov 16]. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=203798 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.600095.

Council of Science Editors:

Vase HF. Interrogating therapeutic manipulation of the endocannabinoid system in the human colon. [Doctoral Dissertation]. University of Aberdeen; 2013. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=203798 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.600095

University of Toronto

13. Lakoff, Alanna. Folate Absorption across the Colon: Caplet Study.

Degree: 2010, University of Toronto

URL: http://hdl.handle.net/1807/30137

►

The purpose of this study was to determine the absorption of [13C]5-formyltetrahydrofolic acid across the human colon with an intact microflora. Bioavailability was determined after… (more)

Subjects/Keywords: folate; caplet; colon

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lakoff, A. (2010). Folate Absorption across the Colon: Caplet Study. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/30137

Chicago Manual of Style (16^th Edition):

Lakoff, Alanna. “Folate Absorption across the Colon: Caplet Study.” 2010. Masters Thesis, University of Toronto. Accessed November 16, 2018. http://hdl.handle.net/1807/30137.

MLA Handbook (7^th Edition):

Lakoff, Alanna. “Folate Absorption across the Colon: Caplet Study.” 2010. Web. 16 Nov 2018.

Vancouver:

Lakoff A. Folate Absorption across the Colon: Caplet Study. [Internet] [Masters thesis]. University of Toronto; 2010. [cited 2018 Nov 16]. Available from: http://hdl.handle.net/1807/30137.

Council of Science Editors:

Lakoff A. Folate Absorption across the Colon: Caplet Study. [Masters Thesis]. University of Toronto; 2010. Available from: http://hdl.handle.net/1807/30137

University of Western Australia

14. Morris, Melinda. Clinical and pathological predictors of survival for stage II and III colon cancer patients treated with or without chemotherapy : a population-based study.

Degree: PhD, 2007, University of Western Australia

URL: http://repository.uwa.edu.au:80/R/?func=dbin-jump-full&object_id=9500&local_base=GEN01-INS01

► [Truncated abstract] Clinical and pathological predictors of survival for stage II and III colon cancer patients treated with or without chemotherapy: a population-based study. Aim:… (more)

▼ [Truncated abstract] Clinical and pathological predictors of survival for stage II and III colon cancer patients treated with or without chemotherapy: a population-based study. Aim: Using a population-based cohort of colorectal cancer (CRC), the major aims of this study were to: 1. Identify clinico-pathological markers that can be used to define a subset of stage II colon cancer patients with excellent prognosis and who therefore do not require referral for adjuvant chemotherapy; 2. Investigate whether there is a survival benefit from the use of adjuvant chemotherapy in a population-based cohort of stage II colon cancer; 3. Investigate stage III colon cancer patients for evidence of predictive markers for response to 5FU chemotherapy; 4. Investigate CRC for age-related differences in clinico-pathological and molecular features. Hypotheses to be tested: 1. A subset of good prognosis stage II colon cancers can be defined using routine pathological markers; 2. Females colon cancer patients gain more survival advantage from 5FU chemotherapy than males; 3. Tumours from young CRC patients have different molecular characteristics to those from older patients; 4. The underlying molecular characteristics of tumour can impact upon the response to 5FU chemotherapy. Methods: The study cohort consisted of 5,971 cases diagnosed between 1993 and 2003 representing over 90% of the CRCs diagnosed in the state of Western Australia. Results: The major findings of this translational research into colon cancer can be summarized as follows: The morphological features of serosal and vascular invasion allow for prognostic stratification of stage II colon cancer into "good" and "poor" prognosis groups. Good prognosis patients can confidently be spared adjuvant chemotherapy, however greater effort should be directed towards ensuring that more poor prognosis patients are referred for chemotherapy. Evidence was obtained for a survival advantage from the use of 5FU chemotherapy in stage II colon cancer patients, particularly women and those with poor prognosis features. Completion of chemotherapy confers a survival advantage, whereas failure to complete regimens results in a survival disadvantage, when compared with patients treated by surgery alone. This was observed for both stage II and III colon cancers. The factors associated with a survival advantage from the use of chemotherapy in stage III colon cancer were patient age more than 55 years, female gender, perforation and lymphocytic response. The age, site and sex distribution of CRCs revealed in this study provides further evidence for two major pathways of colorectal tumourigenesis. The CIN 7 pathway is predominant in distal tumours from young males, while the CIMP+ is predominant in proximal tumours from older females. Conclusions: Population based studies are an important component of translational research. In part, they allow for auditing of disease management in a population. Guideline verification and analysis of the reasons for lack of adherence to guidelines is integral to…

Subjects/Keywords: Chemotherapy; Cancer; Colon (Anatomy); Colon (Anatomy); Colon (Anatomy); Cancer

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Morris, M. (2007). Clinical and pathological predictors of survival for stage II and III colon cancer patients treated with or without chemotherapy : a population-based study. (Doctoral Dissertation). University of Western Australia. Retrieved from http://repository.uwa.edu.au:80/R/?func=dbin-jump-full&object_id=9500&local_base=GEN01-INS01

Chicago Manual of Style (16^th Edition):

Morris, Melinda. “Clinical and pathological predictors of survival for stage II and III colon cancer patients treated with or without chemotherapy : a population-based study.” 2007. Doctoral Dissertation, University of Western Australia. Accessed November 16, 2018. http://repository.uwa.edu.au:80/R/?func=dbin-jump-full&object_id=9500&local_base=GEN01-INS01.

MLA Handbook (7^th Edition):

Morris, Melinda. “Clinical and pathological predictors of survival for stage II and III colon cancer patients treated with or without chemotherapy : a population-based study.” 2007. Web. 16 Nov 2018.

Vancouver:

Morris M. Clinical and pathological predictors of survival for stage II and III colon cancer patients treated with or without chemotherapy : a population-based study. [Internet] [Doctoral dissertation]. University of Western Australia; 2007. [cited 2018 Nov 16]. Available from: http://repository.uwa.edu.au:80/R/?func=dbin-jump-full&object_id=9500&local_base=GEN01-INS01.

Council of Science Editors:

Morris M. Clinical and pathological predictors of survival for stage II and III colon cancer patients treated with or without chemotherapy : a population-based study. [Doctoral Dissertation]. University of Western Australia; 2007. Available from: http://repository.uwa.edu.au:80/R/?func=dbin-jump-full&object_id=9500&local_base=GEN01-INS01

University of Sydney

15. Phillips-Moore, Julie. Controlled trial of hypnotherapy as a treatment for irritable bowel syndrome .

Degree: 2009, University of Sydney

URL: http://hdl.handle.net/2123/4983

► Nineteenth century philosophy and anatomy regarded the nervous system as the only pathway of communication between the brain and body but now, research in the… (more)

▼ Nineteenth century philosophy and anatomy regarded the nervous system as the only pathway of communication between the brain and body but now, research in the field of psychoneuroimmunology (PNI) has provided evidence to prove the age-old belief that there is a connection between the mind (or mental/emotional states) and the body. Researchers in PNI have now shown that the communication between the nervous and immune systems is bi-directional – i.e. there is a psychological reaction to physical disease and a somatic presentation of psychological disorders - and that the immune system, the autonomic nervous system, the endocrine system and the neuropeptide systems all communicate with each other by means of chemicals called messenger molecules or ligands. This paper outlines research into the treatment of Irritable Bowel Syndrome (IBS) with hypnotherapy, taking into account the mind-body connection and treating both the patient’s physiological and emotional/psychological symptoms rather than treating the physiological symptoms only. In other words, using a more holistic approach to the treatment of IBS. IBS is probably the most common functional gastrointestinal disorder encountered by both gastroenterologists and physicians in primary care. It is estimated that from 10% to 25% of the general population suffer from this condition and that it comprises about 30-50% of the gastroenterologists’ workload, yet the aetiology of IBS is unknown and, so far, there is no cure. Researchers are beginning to view IBS as a multi-faceted disorder in which there appears to be a disturbance in the interaction between the intestines, brain, and autonomic nervous system, resulting in an alteration in the regulation of bowel motility and/or sensory function. Most researchers agree that a subset of IBS sufferers have a visceral hypersensitivity of the gut or, more specifically, an increased perception of sensations in the gut. To date, studies of IBS have proposed previous gastroenteritis, small intestine bacterial overgrowth, psychosocial factors, a genetic contribution, and an imbalance of neurotransmitters as either possible causes or playing a part in the development of IBS. It is generally agreed that a patient’s emotional response to stress can exacerbate the condition. In section 1 of the thesis, the introduction, a detailed description and background appropriate to the study undertaken are provided, including aspects of epidemiology, diagnostic symptom criteria and clinical relevance of the Irritable Bowel Syndrome. Previous studies of various forms of treatment for IBS are discussed with the main emphasis being on treatment with hypnotherapy. All these therapies have concentrated on either mind or body treatments whereas this study demonstrates how hypnotherapy, and the use of imagery, addresses both mind and body. Finally, the rationale for the current study and the specific aims of the thesis are outlined. In section 2, the methodology and assessment instruments used in the clinical trial are discussed, as well as recruitment…

Subjects/Keywords: Irritable colon – Pathophysiology; Irritable colon – Psychological aspects; Irritable colon – Treatment; Hypnotism – Therapeutic use

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Phillips-Moore, J. (2009). Controlled trial of hypnotherapy as a treatment for irritable bowel syndrome . (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/4983

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Phillips-Moore, Julie. “Controlled trial of hypnotherapy as a treatment for irritable bowel syndrome .” 2009. Thesis, University of Sydney. Accessed November 16, 2018. http://hdl.handle.net/2123/4983.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Phillips-Moore, Julie. “Controlled trial of hypnotherapy as a treatment for irritable bowel syndrome .” 2009. Web. 16 Nov 2018.

Vancouver:

Phillips-Moore J. Controlled trial of hypnotherapy as a treatment for irritable bowel syndrome . [Internet] [Thesis]. University of Sydney; 2009. [cited 2018 Nov 16]. Available from: http://hdl.handle.net/2123/4983.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Phillips-Moore J. Controlled trial of hypnotherapy as a treatment for irritable bowel syndrome . [Thesis]. University of Sydney; 2009. Available from: http://hdl.handle.net/2123/4983

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Johannesburg

16. Bush, Carol Margaret. A holistic group psychotherapeutic intervention for the treatment of irritable bowel syndrome and its comorobid depression and anxiety .

Degree: 2008, University of Johannesburg

URL: http://hdl.handle.net/10210/1423

► Irritable Bowel Syndrome (IBS) can be described as a bodily idiom - a nonverbal language which may have its roots in unspeakable dilemmas (Griffiths &… (more)

▼ Irritable Bowel Syndrome (IBS) can be described as a bodily idiom - a nonverbal language which may have its roots in unspeakable dilemmas (Griffiths & Griffiths, 1994). The splitting of languages and silencing of the body may be the soil in which such symptoms grow. Unutterable conflicts lead to the symptoms being trapped within the body until the body itself begins to "speak" (Griffiths & Griffiths, 1994). In essence, this study seeks to evaluate the effects of attaching language, feelings and awareness to these symptoms and communicating this with other IBS subjects within the group context. Psychiatric illness is often found in IBS health care seekers (Drossman & Thompson, 1992). The specific aim of this study was to ascertain the effects of a holistic short-term group intervention in the treatment of IBS with comorbid depression and anxiety. The sample consisted of 24 South African women who had been positively diagnosed with severe IBS by either a gastroenterologist or a general practitioner. Furthermore, each subject had to have associated moderate to severe depression and anxiety. Four questionnaires were utilised, namely the Biographical Questionnaire, the Irritable Bowel Syndrome Client Questionnaire, the Personality Assessment Inventory (PAI) and the Functional Bowel Disorder Severity Index (FBDSI). The Biographical Questionnaire mainly requested personal details and sought a family history of psychological disorders. The Irritable Bowel Syndrome Client Questionnaire, based on the standardised Rome Criteria (Drossman, 1994; Drossman, Zhiming, Toner, Creed, Thompson, Read et al., 1995; Talley, Phillips, Melton, Mulvihill, Wiltgen & Zinsmeister, 1989), verified a positive IBS diagnosis, while the Functional Bowel Disorder Severity Index rated the severity of the subject’s IBS. Lastly, the depression score was rated on the depression scale of the Personality Assessment Inventory (PAI) and the anxiety score was rated on the anxiety scale of the PAI. The subjects were divided into two groups of twelve members each - Group 1 was the experimental group and Group 2 was the control group. The group design was a pre-test, post-test control group design where subjects in Group 1 (the experimental group) received group intervention and subjects in Group 2 (the control group) were placed on a waiting list and received no intervention. The subjects in the control group were offered individual therapy once the post-tests were completed. All the subjects completed the IBS Severity Index Questionnaire and the Depression and Anxiety subscales of the Personality Assessment Inventory before commencement of group therapy for Group 1 and again one month after completion of this intervention. The effect of the intervention was determined utilising comparative statistics with reference to the pre-test versus post-test scores. The t-test for the equality of means for between group variance was utilised for two analyses. Firstly, it was used to determine the variance regarding the pre-test scores between Group 1… Advisors/Committee Members: Prof. H.G. Pretorius (advisor).

Subjects/Keywords: Irritable colon patients; Treatment of irritable colon patients; Psychotherapy; Mental depression; Anxiety; Irritable colon research

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APA (6^th Edition):

Bush, C. M. (2008). A holistic group psychotherapeutic intervention for the treatment of irritable bowel syndrome and its comorobid depression and anxiety . (Thesis). University of Johannesburg. Retrieved from http://hdl.handle.net/10210/1423

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bush, Carol Margaret. “A holistic group psychotherapeutic intervention for the treatment of irritable bowel syndrome and its comorobid depression and anxiety .” 2008. Thesis, University of Johannesburg. Accessed November 16, 2018. http://hdl.handle.net/10210/1423.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bush, Carol Margaret. “A holistic group psychotherapeutic intervention for the treatment of irritable bowel syndrome and its comorobid depression and anxiety .” 2008. Web. 16 Nov 2018.

Vancouver:

Bush CM. A holistic group psychotherapeutic intervention for the treatment of irritable bowel syndrome and its comorobid depression and anxiety . [Internet] [Thesis]. University of Johannesburg; 2008. [cited 2018 Nov 16]. Available from: http://hdl.handle.net/10210/1423.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bush CM. A holistic group psychotherapeutic intervention for the treatment of irritable bowel syndrome and its comorobid depression and anxiety . [Thesis]. University of Johannesburg; 2008. Available from: http://hdl.handle.net/10210/1423

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Johannesburg

17. Mayer, Aliza. Coping styles used by patients suffering from irritable bowel syndrome .

Degree: 2012, University of Johannesburg

URL: http://hdl.handle.net/10210/5439

► The purpose of this study was to ascertain whether patients suffering from irritable bowel syndrome (IBS) differed from non-IBS clients in terms of their coping… (more)

Subjects/Keywords: Irritable colon - Research - South Africa.; Irritable colon - Patients - Research - South Africa.; Irritable colon - Psychological aspects.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mayer, A. (2012). Coping styles used by patients suffering from irritable bowel syndrome . (Thesis). University of Johannesburg. Retrieved from http://hdl.handle.net/10210/5439

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mayer, Aliza. “Coping styles used by patients suffering from irritable bowel syndrome .” 2012. Thesis, University of Johannesburg. Accessed November 16, 2018. http://hdl.handle.net/10210/5439.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mayer, Aliza. “Coping styles used by patients suffering from irritable bowel syndrome .” 2012. Web. 16 Nov 2018.

Vancouver:

Mayer A. Coping styles used by patients suffering from irritable bowel syndrome . [Internet] [Thesis]. University of Johannesburg; 2012. [cited 2018 Nov 16]. Available from: http://hdl.handle.net/10210/5439.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mayer A. Coping styles used by patients suffering from irritable bowel syndrome . [Thesis]. University of Johannesburg; 2012. Available from: http://hdl.handle.net/10210/5439

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas A&M University

18. Triff, Karen. Assessment of Histone Tail Modifications and Transcriptional Profiling during Colon Cancer Progression: Effect of Chemoprotective Natural Compounds.

Degree: PhD, Microbiology, 2016, Texas A&M University

URL: http://hdl.handle.net/1969.1/156811

► During colon cancer development, epigenetic alterations contribute to the dysregulation of major cellular functions and signaling pathways. Recent evidence suggests that nutritionally chemoprotective components that… (more)

▼ During colon cancer development, epigenetic alterations contribute to the dysregulation of major cellular functions and signaling pathways. Recent evidence suggests that nutritionally chemoprotective components that influence cellular dynamics in the colonic epithelium can also directly affect their epigenetic landscape. We hypothesize that the chemoprotective nutritional bioactives found in fish oil and fermentable fiber can act as epigenetic modifiers and mechanistically counteract epigenetic distortions associated with colonic tumorigenesis. Fermentable fiber generates short-chain fatty acids (SCFA), e.g., butyrate, in the lumen of the colon that can serve as a chemoprotective histone deacetylase inhibitor and/or as an acetylation substrate for histone acetylases. In addition, n-3 polyunsaturated fatty acids (n-3 PUFAs) in fish oil can affect the chromatin landscape by acting as ligands for tumor suppressive nuclear receptors. In an effort to gain insight into the extensive dimension of post-translational modifications in histones (including H3K4me3 and H3K9ac) and elucidate the chemoprotective impact of dietary bioactive compounds on transcriptional control in a colon cancer preclinical model, we generated high-resolution genome-wide RNA (RNA-Seq) and ?chromatin-state? (H3K4me3-seq and H3K9ac-seq) maps for intestinal (epithelial colonocytes) crypts in rats treated with a colon carcinogen and fed bioactive (i) fish oil (ii) butyrate (in the form of a fermentable fiber a rich source of SCFA), (iii) a combination of fish oil plus butyrate or (iv) control diets. Poor correlation was observed between differentially transcribed (DE) and enriched genes (DERs) at multiple epigenetic levels in fat x fiber dietary combinations and in the presence/absence of carcinogen. The genome-wide carcinogen (AOM) effects were most prevalent at the RNA (116 DE genes) and K4me3 (7678 DERs including 3792 genes) levels. Pathway analysis of the differentially transcribed genes after AOM exposure indicated a strong link to interferon-associated innate immune responses often associated with anti-microbial activity, while K4me3 DERs were strongly linked to colon tumorigenesis. However, these changes in K4me3 enrichment were not reflected at the transcriptional level during the early stages of cancer progression. Therefore, we propose that carcinogen-induced changes in genes with K4me3 DERs are harbingers of future transcriptional events, which drive malignant transformation of the colon cells. We also demonstrated that the combinatorial diet (fish oil + pectin) was synergistically chemoprotective, and uniquely affected epigenetic profiles in the intestinal epithelium, e.g., upregulating lipid catabolism and beta-oxidation associated genes. These genes were linked to activated ligand-dependent nuclear receptors associated with n-3 PUFAs and were also correlated with the inhibition of lipogenesis and a decreased concentration of cholesterol. Interestingly, only a subset of these genes was affected in animals fed fish oil without pectin, and… Advisors/Committee Members: Chapkin, Robert S (advisor), Zoran, Mark (advisor), Gomer, Richard (committee member), Lupton, Joanne (committee member).

Subjects/Keywords: epigenetics; colon cancer; chemoprevention

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Triff, K. (2016). Assessment of Histone Tail Modifications and Transcriptional Profiling during Colon Cancer Progression: Effect of Chemoprotective Natural Compounds. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/156811

Chicago Manual of Style (16^th Edition):

Triff, Karen. “Assessment of Histone Tail Modifications and Transcriptional Profiling during Colon Cancer Progression: Effect of Chemoprotective Natural Compounds.” 2016. Doctoral Dissertation, Texas A&M University. Accessed November 16, 2018. http://hdl.handle.net/1969.1/156811.

MLA Handbook (7^th Edition):

Triff, Karen. “Assessment of Histone Tail Modifications and Transcriptional Profiling during Colon Cancer Progression: Effect of Chemoprotective Natural Compounds.” 2016. Web. 16 Nov 2018.

Vancouver:

Triff K. Assessment of Histone Tail Modifications and Transcriptional Profiling during Colon Cancer Progression: Effect of Chemoprotective Natural Compounds. [Internet] [Doctoral dissertation]. Texas A&M University; 2016. [cited 2018 Nov 16]. Available from: http://hdl.handle.net/1969.1/156811.

Council of Science Editors:

Triff K. Assessment of Histone Tail Modifications and Transcriptional Profiling during Colon Cancer Progression: Effect of Chemoprotective Natural Compounds. [Doctoral Dissertation]. Texas A&M University; 2016. Available from: http://hdl.handle.net/1969.1/156811

Universidad de Valladolid

19. Uña Cidón, María Esther. Evaluación de dos estrategias de seguimiento del cáncer de colon desde el punto de vista del coste-efectividad.

Degree: 2009, Universidad de Valladolid

URL: http://uvadoc.uva.es/handle/10324/711

► Este trabajo tiene como objetivo la evaluación comparativa desde el punto de vista del coste-efectividad de dos estrategias de seguimiento del Cáncer de Colon llevadas… (more)

Subjects/Keywords: Colon-Cáncer-Coste-eficacia

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APA (6^th Edition):

Uña Cidón, M. E. (2009). Evaluación de dos estrategias de seguimiento del cáncer de colon desde el punto de vista del coste-efectividad. (Thesis). Universidad de Valladolid. Retrieved from http://uvadoc.uva.es/handle/10324/711

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Uña Cidón, María Esther. “Evaluación de dos estrategias de seguimiento del cáncer de colon desde el punto de vista del coste-efectividad.” 2009. Thesis, Universidad de Valladolid. Accessed November 16, 2018. http://uvadoc.uva.es/handle/10324/711.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Uña Cidón, María Esther. “Evaluación de dos estrategias de seguimiento del cáncer de colon desde el punto de vista del coste-efectividad.” 2009. Web. 16 Nov 2018.

Vancouver:

Uña Cidón ME. Evaluación de dos estrategias de seguimiento del cáncer de colon desde el punto de vista del coste-efectividad. [Internet] [Thesis]. Universidad de Valladolid; 2009. [cited 2018 Nov 16]. Available from: http://uvadoc.uva.es/handle/10324/711.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Uña Cidón ME. Evaluación de dos estrategias de seguimiento del cáncer de colon desde el punto de vista del coste-efectividad. [Thesis]. Universidad de Valladolid; 2009. Available from: http://uvadoc.uva.es/handle/10324/711

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidad de Valladolid

20. Herranz Bachiller, María Teresa. Papel de la calprotectina fecal como predictor de enfermedad orgánica: aplicabilidad en la diarrea crónica y la recurrencia endoscópica de la enfermedad de Crohn.

Degree: 2016, Universidad de Valladolid

URL: http://uvadoc.uva.es/handle/10324/16869

► Introducción: La diarrea crónica es una patología frecuente en la consulta de aparato digestivo. La causa más común de diarrea son los trastornos funcionales, la… (more)

▼ Introducción: La diarrea crónica es una patología frecuente en la consulta de aparato digestivo. La causa más común de diarrea son los trastornos funcionales, la diferenciación entre patología orgánica de funcional puede conllevar la realización de muchas pruebas complementarias, entre ellas la colonoscopia. La demanda creciente de endoscopias hace necesario la búsqueda de un marcador sensible y específico que nos permita clasificar a los pacientes de forma segura y así evitar colonoscopias innecesarias. La calprotectina fecal es un marcador biológico de inflamación intestinal utilizado generalmente para el diagnóstico y seguimiento de la EII. En el presente estudio valoraremos el papel de la calprotectina fecal como indicador de patología intestinal en la diarrea crónica y para establecer la necesidad de una colonoscopia, así como, su utilidad en la recurrencia endoscópica de la enfermedad de Crohn. Material y métodos: Se trata de un estudio retrospectivo observacional dividido en dos partes; la primera pacientes en estudio por diarrea crónica con una determinación de calprotectina fecal y colonoscopia con biopsias, en este estudio se valoraran dos tipos de calprotectina fecal ( ELISA y ELiA), lo cual nos obliga a analizar la calprotectina fecal como variable continua y discontinua. La segunda parte analiza pacientes con enfermedad de Crohn operados a los que se realiza una colonoscopia de control. En ambos se realizaran estudios univariantes y multivariantes para la determinación de variables predictoras; así como búsqueda de puntos de corte mediante curvas ROC. En el primero además realizaremos scores diagnósticos a partir de un análisis de regresión logística binario. Resultados: La CF, es la variable discontinua que ofrece una mayor sensibilidad (91,8%) y VPN (94%) para la colonoscopia con hallazgos de gravedad y la varibale que obtiene mayor puntuación en el score diagnóstico. También es la variable más sensible para EII (100%, 100%), para CM (63,6%, 91,1%). Para el CCR solo presento una sensibilidad del 71,4%, siendo la PCR la variable más sensible. La presencia de pólipos, divertículos, el tratamiento con AINEs, o IBPS y la edad se asocia a niveles de CF más elevados, mientras que el tabaquismo reduce estos valores. El valor de la CF aumenta según aumenta el índice de Rutgeerts. El AUC de la CF en la recurrencia endoscópica es 0.74 con un punto de corte óptimo de 60mcg/g con una S 88% y E 58% en detectar recurrencia. Conclusiones: La CF es un test útil y eficaz en pacientes con diarrea crónica, puesto que, es la variable que presenta mayor sensibilidad y VPN de entre todas las variables recogidas como predictora de hallazgos de gravedad en la colonoscopia. No es un buen marcador de CCR dada su baja sensibilidad y no es un buen indicador de toma de biopsias para descartar CM. Es necesario que la estandarización de los métodos de medición de CF. Es el test con mayor capacidad predictiva de la recurrencia endoscópica en la EC, pero de momento no puede sustituir a la colonoscopia.

Subjects/Keywords: Crohn, Enfermedad de; Colon-Enfermedades

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Herranz Bachiller, M. T. (2016). Papel de la calprotectina fecal como predictor de enfermedad orgánica: aplicabilidad en la diarrea crónica y la recurrencia endoscópica de la enfermedad de Crohn. (Thesis). Universidad de Valladolid. Retrieved from http://uvadoc.uva.es/handle/10324/16869

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Herranz Bachiller, María Teresa. “Papel de la calprotectina fecal como predictor de enfermedad orgánica: aplicabilidad en la diarrea crónica y la recurrencia endoscópica de la enfermedad de Crohn.” 2016. Thesis, Universidad de Valladolid. Accessed November 16, 2018. http://uvadoc.uva.es/handle/10324/16869.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Herranz Bachiller, María Teresa. “Papel de la calprotectina fecal como predictor de enfermedad orgánica: aplicabilidad en la diarrea crónica y la recurrencia endoscópica de la enfermedad de Crohn.” 2016. Web. 16 Nov 2018.

Vancouver:

Herranz Bachiller MT. Papel de la calprotectina fecal como predictor de enfermedad orgánica: aplicabilidad en la diarrea crónica y la recurrencia endoscópica de la enfermedad de Crohn. [Internet] [Thesis]. Universidad de Valladolid; 2016. [cited 2018 Nov 16]. Available from: http://uvadoc.uva.es/handle/10324/16869.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Herranz Bachiller MT. Papel de la calprotectina fecal como predictor de enfermedad orgánica: aplicabilidad en la diarrea crónica y la recurrencia endoscópica de la enfermedad de Crohn. [Thesis]. Universidad de Valladolid; 2016. Available from: http://uvadoc.uva.es/handle/10324/16869

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Utah

21. Sandoval, Imelda Tumanan. Dysregulation of retinoid biosynthesis and metabolism during colon carcinogenesis;.

Degree: PhD, Medicinal Chemistry;, 2006, University of Utah

URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1298/rec/362

► The research work presented in this dissertation describes the dysregulation of the retinoid biosynthetic and metabolic pathways accompanying colon carcinogenesis. Colon cancer remains the third… (more)

▼ The research work presented in this dissertation describes the dysregulation of the retinoid biosynthetic and metabolic pathways accompanying colon carcinogenesis. Colon cancer remains the third leading cause of cancer deaths in the United States. A better understanding of the molecular mechanisms underlying colon tumorigenesis is needed to develop more effective therapies against colon cancer. Chapter 1 is an introduction on colon cancer and retinoids. The relationship between normal intestinal development and progression of colon cancer, including a background on adenomatous polyposis coli (APC) and several colorectal cancer syndromes are presented in the first half of Chapter 1. The latter part is a discussion of retinoid storage, biosynthesis and metabolism. It also summarizes what has been reported about the role of retinoids in normal colon function and their therapeutic effects on various human tumors. Retinol dehydrogenase like (DHRS9) is a colon-specific retinol dehydrogenase that is down-regulated in colon carcinomas. Chapter 2 describes studies that were undertaken to confirm the retinol dehydrogenase activity of DHRS9, demonstrate impairment of the retinoid biosynthetic capabilities of colon carcinoma cells and investigate the possible control of retinoic acid biosynthesis by APC through regulation of DHRS9 expression. A brief description of the retinol dehydrogenase activity of three zebrafish retinol dehydrogenases – rdh1, rdh1l and rdh5, is presented in Chapter 3. A discussion on the regulation of retinoid biosynthesis by APC and the importance of retinoic acid in zebrafish eye and gut development is also included. This is followed by Chapter 4, which describes significant differences in the dysregulation of the retinoid biosynthetic pathway in human colon carcinomas compared to the Apc[min/+ mouse, an established animal model system for studying colon cancer. Chapter 5 shows that the dysregulation of retinoid biosynthesis at multiple points along the pathway is a common occurrence in human colon carcinomas and colon carcinoma cell lines. Studies on cellular retinol binding protein II (CRBPII), its importance in normal intestinal development and retinol uptake are presented as well. Chapter 5 also discusses a broader role for APC in regulating intestinal differentiation by controlling several retinoid biosynthetic components. Conclusions and implications of presented findings are discussed in Chapter 6.

Subjects/Keywords: Colon; Retinoids

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sandoval, I. T. (2006). Dysregulation of retinoid biosynthesis and metabolism during colon carcinogenesis;. (Doctoral Dissertation). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1298/rec/362

Chicago Manual of Style (16^th Edition):

Sandoval, Imelda Tumanan. “Dysregulation of retinoid biosynthesis and metabolism during colon carcinogenesis;.” 2006. Doctoral Dissertation, University of Utah. Accessed November 16, 2018. http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1298/rec/362.

MLA Handbook (7^th Edition):

Sandoval, Imelda Tumanan. “Dysregulation of retinoid biosynthesis and metabolism during colon carcinogenesis;.” 2006. Web. 16 Nov 2018.

Vancouver:

Sandoval IT. Dysregulation of retinoid biosynthesis and metabolism during colon carcinogenesis;. [Internet] [Doctoral dissertation]. University of Utah; 2006. [cited 2018 Nov 16]. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1298/rec/362.

Council of Science Editors:

Sandoval IT. Dysregulation of retinoid biosynthesis and metabolism during colon carcinogenesis;. [Doctoral Dissertation]. University of Utah; 2006. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1298/rec/362

University of Aberdeen

22. Padidar, Sara. Obesity and colon cancer links : proteomic and transcriptomic investigation of associated signalling targets.

Degree: 2009, University of Aberdeen

URL: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=135783 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.521345

► This project has identified increased adiposity and altered plasma leptin levels to be not associated with colon sensitivity to a colon carcinogen using diet-induced obesity… (more)

Subjects/Keywords: 616.994; Obesity : Colon (Diseases) : Cancer

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Padidar, S. (2009). Obesity and colon cancer links : proteomic and transcriptomic investigation of associated signalling targets. (Doctoral Dissertation). University of Aberdeen. Retrieved from http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=135783 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.521345

Chicago Manual of Style (16^th Edition):

Padidar, Sara. “Obesity and colon cancer links : proteomic and transcriptomic investigation of associated signalling targets.” 2009. Doctoral Dissertation, University of Aberdeen. Accessed November 16, 2018. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=135783 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.521345.

MLA Handbook (7^th Edition):

Padidar, Sara. “Obesity and colon cancer links : proteomic and transcriptomic investigation of associated signalling targets.” 2009. Web. 16 Nov 2018.

Vancouver:

Padidar S. Obesity and colon cancer links : proteomic and transcriptomic investigation of associated signalling targets. [Internet] [Doctoral dissertation]. University of Aberdeen; 2009. [cited 2018 Nov 16]. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=135783 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.521345.

Council of Science Editors:

Padidar S. Obesity and colon cancer links : proteomic and transcriptomic investigation of associated signalling targets. [Doctoral Dissertation]. University of Aberdeen; 2009. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=135783 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.521345

University of Minnesota

23. Chow, Christopher J. Does patient rurality predict quality colon cancer care? a population based study.

Degree: MS, Clinical Research, 2013, University of Minnesota

URL: http://purl.umn.edu/157355

►

University of Minnesota M.S. thesis. June 2013. Major: Clinical Research. Advisor: David A. Rothenberger, MD. 1 computer file (PDF); vi, 22 pages.

Introduction: Over fifty… (more)

Subjects/Keywords: Adenocarcinoma; Colon; Outcomes; Quality

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APA (6^th Edition):

Chow, C. J. (2013). Does patient rurality predict quality colon cancer care? a population based study. (Masters Thesis). University of Minnesota. Retrieved from http://purl.umn.edu/157355

Chicago Manual of Style (16^th Edition):

Chow, Christopher J. “Does patient rurality predict quality colon cancer care? a population based study.” 2013. Masters Thesis, University of Minnesota. Accessed November 16, 2018. http://purl.umn.edu/157355.

MLA Handbook (7^th Edition):

Chow, Christopher J. “Does patient rurality predict quality colon cancer care? a population based study.” 2013. Web. 16 Nov 2018.

Vancouver:

Chow CJ. Does patient rurality predict quality colon cancer care? a population based study. [Internet] [Masters thesis]. University of Minnesota; 2013. [cited 2018 Nov 16]. Available from: http://purl.umn.edu/157355.

Council of Science Editors:

Chow CJ. Does patient rurality predict quality colon cancer care? a population based study. [Masters Thesis]. University of Minnesota; 2013. Available from: http://purl.umn.edu/157355

University of Aberdeen

24. Vase, Hollie Francesca.; Rowett Institute of Nutrition and Health. Interrogating therapeutic manipulation of the endocannabinoid system in the human colon.

Degree: 2013, University of Aberdeen

URL: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=203798 ; http://digitool2.abdn.ac.uk:1801/webclient/DeliveryManager?pid=203798&custom_att_2=simple_viewer

Subjects/Keywords: Colon (Anatomy)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Vase, H. F. ;. R. I. o. N. a. H. (2013). Interrogating therapeutic manipulation of the endocannabinoid system in the human colon. (Doctoral Dissertation). University of Aberdeen. Retrieved from http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=203798 ; http://digitool2.abdn.ac.uk:1801/webclient/DeliveryManager?pid=203798&custom_att_2=simple_viewer

Chicago Manual of Style (16^th Edition):

Vase, Hollie Francesca ; Rowett Institute of Nutrition and Health. “Interrogating therapeutic manipulation of the endocannabinoid system in the human colon.” 2013. Doctoral Dissertation, University of Aberdeen. Accessed November 16, 2018. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=203798 ; http://digitool2.abdn.ac.uk:1801/webclient/DeliveryManager?pid=203798&custom_att_2=simple_viewer.

MLA Handbook (7^th Edition):

Vase, Hollie Francesca ; Rowett Institute of Nutrition and Health. “Interrogating therapeutic manipulation of the endocannabinoid system in the human colon.” 2013. Web. 16 Nov 2018.

Vancouver:

Vase HF;RIoNaH. Interrogating therapeutic manipulation of the endocannabinoid system in the human colon. [Internet] [Doctoral dissertation]. University of Aberdeen; 2013. [cited 2018 Nov 16]. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=203798 ; http://digitool2.abdn.ac.uk:1801/webclient/DeliveryManager?pid=203798&custom_att_2=simple_viewer.

Council of Science Editors:

Vase HF;RIoNaH. Interrogating therapeutic manipulation of the endocannabinoid system in the human colon. [Doctoral Dissertation]. University of Aberdeen; 2013. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=203798 ; http://digitool2.abdn.ac.uk:1801/webclient/DeliveryManager?pid=203798&custom_att_2=simple_viewer

25. Valdez Junco, Cristhine Natalie. Conocimientos sobre el cáncer de colon y sus medidas preventivas en una población de choferes. Empresa de transporte y servicios especiales sur Lima. Universidad Nacional Mayor de San Marcos. Chorrillos, 2010.

Degree: 2011, National University of San Marcos

URL: http://cybertesis.unmsm.edu.pe/handle/cybertesis/1319 ; http://cybertesis.unmsm.edu.pe/bitstream/cybertesis%2F1319/1/bitstream

►

En el estudio titulado “Conocimientos sobre el Cáncer de Colon y sus Medidas Preventivas en una Población de Choferes. Empresa de Transporte y Servicios Especiales… (more)

▼

En el estudio titulado “Conocimientos sobre el Cáncer de Colon y sus Medidas Preventivas en una Población de Choferes. Empresa de Transporte y Servicios Especiales Sur Lima Chorrillos. 2010” ha sido realizado en la ciudad de Lima, debido a que el Cáncer de Colon es considerado actualmente una neoplasia que encuentra en aumento a nivel mundial. Es por ello la importancia del Rol de la Enfermera en la promoción de la salud y prevención de las enfermedades, fomentando los estilos de vida saludable generando entornos laborales saludables como parte de las medidas preventivas para así disminuir el riesgo de enfermar en la población y contribuir en el mejoramiento de las condiciones de salud y productividad laboral. El objetivo fue determinar los conocimientos sobre el cáncer de colon y sus medidas preventivas en los choferes que laboran en la Empresa de Transporte Sur Lima, con el propósito de incentivar al Profesional de Enfermería a asumir su rol preventivo - promocional en los centros laborales y que la gerencia de la Empresa de Transportes desarrolle acciones que fomenten la salud del personal y disminuir sus factores de riesgo. El diseño metodológico del trabajo es de tipo cuantitativo, nivel aplicativo, método descriptivo de corte transversal. La población de estudio estuvo conformada por 60 choferes cuyas edades van de los 30 a 60 años, donde se concluye que la mayoría el 78.3% (47) de los choferes que laboran en la Empresa de Transporte no conocen sobre el Cáncer de Colon y sus medidas preventivas. Palabras Claves: Cáncer de Colon, Conocimientos, Medidas Preventivas.

– In the study entitled "Knowledge of Colon Cancer and Preventive Measures in a Population of Drivers. Transportation Company and Special Services South Lima Chorrillos. 2010“ has been held in Lima due to Colon Cancer is considered nowadays a neoplasm that is increasing worldwide. That is why the importance of the role of the nurse in health promotion and disease prevention by promoting healthy lifestyles creating healthy work environments as part of preventive measures in order to reduce the risk of disease in the population and contribute in improving health conditions and productivity. The objective was to determine knowledge about colon cancer and its preventive measures in the drivers working in the South Lima Transportation Company, in order to encourage nursing professionals to assume its role of prevention - promotion in the workplace and management of the Transport Company to develop actions that promote personal health and reduce their risk factors. The methodological design of this study is quantitative, application level, cross sectional method. The study population consisted of 60 drivers ranging in age from 30 to 60 years, which concludes that most, 78.3% (47) of drivers who work in the Carrier do not know about Colon Cancer and preventive measures. Keywords: Colon cancer, knowledge. Preventive measures.

Advisors/Committee Members: Rivas Díaz De Cabrera, Luisa Hortensia.

Subjects/Keywords: Colon (Anatomía) - Cáncer; Choferes - Actitudes

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Valdez Junco, C. N. (2011). Conocimientos sobre el cáncer de colon y sus medidas preventivas en una población de choferes. Empresa de transporte y servicios especiales sur Lima. Universidad Nacional Mayor de San Marcos. Chorrillos, 2010. (Thesis). National University of San Marcos. Retrieved from http://cybertesis.unmsm.edu.pe/handle/cybertesis/1319 ; http://cybertesis.unmsm.edu.pe/bitstream/cybertesis%2F1319/1/bitstream

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Valdez Junco, Cristhine Natalie. “Conocimientos sobre el cáncer de colon y sus medidas preventivas en una población de choferes. Empresa de transporte y servicios especiales sur Lima. Universidad Nacional Mayor de San Marcos. Chorrillos, 2010.” 2011. Thesis, National University of San Marcos. Accessed November 16, 2018. http://cybertesis.unmsm.edu.pe/handle/cybertesis/1319 ; http://cybertesis.unmsm.edu.pe/bitstream/cybertesis%2F1319/1/bitstream.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Valdez Junco, Cristhine Natalie. “Conocimientos sobre el cáncer de colon y sus medidas preventivas en una población de choferes. Empresa de transporte y servicios especiales sur Lima. Universidad Nacional Mayor de San Marcos. Chorrillos, 2010.” 2011. Web. 16 Nov 2018.

Vancouver:

Valdez Junco CN. Conocimientos sobre el cáncer de colon y sus medidas preventivas en una población de choferes. Empresa de transporte y servicios especiales sur Lima. Universidad Nacional Mayor de San Marcos. Chorrillos, 2010. [Internet] [Thesis]. National University of San Marcos; 2011. [cited 2018 Nov 16]. Available from: http://cybertesis.unmsm.edu.pe/handle/cybertesis/1319 ; http://cybertesis.unmsm.edu.pe/bitstream/cybertesis%2F1319/1/bitstream.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Valdez Junco CN. Conocimientos sobre el cáncer de colon y sus medidas preventivas en una población de choferes. Empresa de transporte y servicios especiales sur Lima. Universidad Nacional Mayor de San Marcos. Chorrillos, 2010. [Thesis]. National University of San Marcos; 2011. Available from: http://cybertesis.unmsm.edu.pe/handle/cybertesis/1319 ; http://cybertesis.unmsm.edu.pe/bitstream/cybertesis%2F1319/1/bitstream

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Johannesburg

26. Schultz, Jacquelyn Loren. A study to determine the effectiveness of the homoeopathic remedies Argentum nitricum 6CH and Lycopodium clavatum 6CH on the individualised treatment of patients suffering from irritable bowel syndrome .

Degree: 2014, University of Johannesburg

URL: http://hdl.handle.net/10210/10589

► The aim of this study was to determine the effectiveness of Argentum nitricum 6CH and Lycopodium clavatum 6CH in the individualised treatment of patients suffering… (more)

Subjects/Keywords: Irritable colon - Homeopathic treatment

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APA (6^th Edition):

Schultz, J. L. (2014). A study to determine the effectiveness of the homoeopathic remedies Argentum nitricum 6CH and Lycopodium clavatum 6CH on the individualised treatment of patients suffering from irritable bowel syndrome . (Thesis). University of Johannesburg. Retrieved from http://hdl.handle.net/10210/10589

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Schultz, Jacquelyn Loren. “A study to determine the effectiveness of the homoeopathic remedies Argentum nitricum 6CH and Lycopodium clavatum 6CH on the individualised treatment of patients suffering from irritable bowel syndrome .” 2014. Thesis, University of Johannesburg. Accessed November 16, 2018. http://hdl.handle.net/10210/10589.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Schultz, Jacquelyn Loren. “A study to determine the effectiveness of the homoeopathic remedies Argentum nitricum 6CH and Lycopodium clavatum 6CH on the individualised treatment of patients suffering from irritable bowel syndrome .” 2014. Web. 16 Nov 2018.

Vancouver:

Schultz JL. A study to determine the effectiveness of the homoeopathic remedies Argentum nitricum 6CH and Lycopodium clavatum 6CH on the individualised treatment of patients suffering from irritable bowel syndrome . [Internet] [Thesis]. University of Johannesburg; 2014. [cited 2018 Nov 16]. Available from: http://hdl.handle.net/10210/10589.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Schultz JL. A study to determine the effectiveness of the homoeopathic remedies Argentum nitricum 6CH and Lycopodium clavatum 6CH on the individualised treatment of patients suffering from irritable bowel syndrome . [Thesis]. University of Johannesburg; 2014. Available from: http://hdl.handle.net/10210/10589

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Sul

27. Bordin, Diana Lilian. Ativação de autofagia com oxaliplatina em células de câncer colorretal.

Degree: 2013, Universidade do Rio Grande do Sul

URL: http://hdl.handle.net/10183/96855

►

As céluals tumorais estão constantemente expostas a flutuações nas concentrações de nutrientes e oxigênio no microambiente tumoral. Através da ativação de diferentes vias de sinalização,… (more)

▼

As céluals tumorais estão constantemente expostas a flutuações nas concentrações de nutrientes e oxigênio no microambiente tumoral. Através da ativação de diferentes vias de sinalização, as células tumorais sofrem uma reprogramação metabólica a fim de suportar as condições hostis impostas pelo microambiente tumoral. Uma das vias de sinalização ativada nessas condições é a autofagia, a qual tem sido considerada um dos principais mecanismos de sobrevivência celular em condições de estresse. Além disso, muitos medicamentos anti-câncer, como os agentes alquilantes, tem sido implicados na indução de autofagia. Apesar da autofagia contribuir com a sobrevivência da célula, uma superativação da via autofágica por períodos prolongados pode contribuir com a morte celular, o que faz com que o papel da autofagia no câncer seja ainda bastante debatido. Neste trabalho, buscou-se avaliar o papel da autofagia induzida em células de câncer colorretal da linhagem HCT116 continuamente cultivadas em baixa concentração de glicose e submetidas ao tratamento com o agente alquilante oxaliplatina. Os resultados demonstraram que a autofagia induzida em células HCT116 nessas condições exerce um papel citoprotetor, contribuindo para a resistência ao tratamento com oxaliplatina. A ativação da autofagia pelo tratamento com oxaliplatina em baixa concentração de glicose foi capaz de manter os níveis intracelualres de ATP e de reduzir a morte celular por apoptose. A utilização de inibidores ou de um ativador farmacológico da via autofágica, em combinação com a oxaliplatina, foi capaz de sensibilizar células HCT116 tratadas em baixa concentração de glicose, aumentando a morte celular por apoptose. Além disso, a indução de autofagia pela oxaliplatina foi mediada pela ativação de AMPK e inibição de mTOR. Estes dados demonstram que a ativação da autofagia em células de câncer colorretal HCT116 expostas a baixa concentração de glicose contribui para resistência ao tratamento com oxaliplatina. Estes dados também sugerem que a manipulação da via autofágica, pela sua inibição ou superativação, pode fornecer um maneira eficiente de limitar a progressão do tumor e aumentar a eficiência dos regimes quimioterápicos.

Tumor cells are constantly exposed to nutrients and oxygen concentration fluctuations at tumor microenvironment. Through activation of different signaling pathways, tumor cells undergo metabolic reprogramming to tolerate hostile conditions imposed by tumor microenvironment. One of the activated signaling pathways in such conditions is autophagy, which has been considered one of the central mechanisms of cell survival in stress conditions. Furthermore, many anticancer drugs, like alkylanting agents, have been implicated in autophagy induction. Despite autophagy contribution to cell survival, the autophagic pathway activation for prolonged periods may contribute to cell death, which creates extensively debates about the role of autophagy in cancer. In the present work we intended to evaluate the role of autophagy induced in colorectal cancer cells…

Advisors/Committee Members: Henriques, Joao Antonio Pegas.

Subjects/Keywords: Câncer; Colon; Oxaliplatina; Autofagia

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bordin, D. L. (2013). Ativação de autofagia com oxaliplatina em células de câncer colorretal. (Thesis). Universidade do Rio Grande do Sul. Retrieved from http://hdl.handle.net/10183/96855

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bordin, Diana Lilian. “Ativação de autofagia com oxaliplatina em células de câncer colorretal.” 2013. Thesis, Universidade do Rio Grande do Sul. Accessed November 16, 2018. http://hdl.handle.net/10183/96855.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bordin, Diana Lilian. “Ativação de autofagia com oxaliplatina em células de câncer colorretal.” 2013. Web. 16 Nov 2018.

Vancouver:

Bordin DL. Ativação de autofagia com oxaliplatina em células de câncer colorretal. [Internet] [Thesis]. Universidade do Rio Grande do Sul; 2013. [cited 2018 Nov 16]. Available from: http://hdl.handle.net/10183/96855.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bordin DL. Ativação de autofagia com oxaliplatina em células de câncer colorretal. [Thesis]. Universidade do Rio Grande do Sul; 2013. Available from: http://hdl.handle.net/10183/96855

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Aberdeen

28. Narayanan, Sabrina. The effect of folic acid and genetic polymorphisms on DNA stability and colorectal cancer.

Degree: PhD, 2001, University of Aberdeen

URL: http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU143729 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.369562

► The aim of this study was to investigate the influence of folate on DNA stability and DNA methylation in three different systems. (i) Folate deficiency… (more)

Subjects/Keywords: 572; Colon

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Narayanan, S. (2001). The effect of folic acid and genetic polymorphisms on DNA stability and colorectal cancer. (Doctoral Dissertation). University of Aberdeen. Retrieved from http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU143729 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.369562

Chicago Manual of Style (16^th Edition):

Narayanan, Sabrina. “The effect of folic acid and genetic polymorphisms on DNA stability and colorectal cancer.” 2001. Doctoral Dissertation, University of Aberdeen. Accessed November 16, 2018. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU143729 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.369562.

MLA Handbook (7^th Edition):

Narayanan, Sabrina. “The effect of folic acid and genetic polymorphisms on DNA stability and colorectal cancer.” 2001. Web. 16 Nov 2018.

Vancouver:

Narayanan S. The effect of folic acid and genetic polymorphisms on DNA stability and colorectal cancer. [Internet] [Doctoral dissertation]. University of Aberdeen; 2001. [cited 2018 Nov 16]. Available from: http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU143729 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.369562.

Council of Science Editors:

Narayanan S. The effect of folic acid and genetic polymorphisms on DNA stability and colorectal cancer. [Doctoral Dissertation]. University of Aberdeen; 2001. Available from: http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU143729 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.369562

East Carolina University

29. White, Daniel. The Effects of Gastrin and Hox-A1 on HT-29 Cell Proliferation.

Degree: 2013, East Carolina University

URL: http://hdl.handle.net/10342/4187

► Gastrin is a gastrointestinal peptide hormone synthesized in G cells and secreted in the antrum of the stomach. Though its primary role is to stimulate… (more)

Subjects/Keywords: Biology; Gastrin; Colon (Anatomy) – Cancer

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

White, D. (2013). The Effects of Gastrin and Hox-A1 on HT-29 Cell Proliferation. (Thesis). East Carolina University. Retrieved from http://hdl.handle.net/10342/4187

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

White, Daniel. “The Effects of Gastrin and Hox-A1 on HT-29 Cell Proliferation.” 2013. Thesis, East Carolina University. Accessed November 16, 2018. http://hdl.handle.net/10342/4187.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

White, Daniel. “The Effects of Gastrin and Hox-A1 on HT-29 Cell Proliferation.” 2013. Web. 16 Nov 2018.

Vancouver:

White D. The Effects of Gastrin and Hox-A1 on HT-29 Cell Proliferation. [Internet] [Thesis]. East Carolina University; 2013. [cited 2018 Nov 16]. Available from: http://hdl.handle.net/10342/4187.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

White D. The Effects of Gastrin and Hox-A1 on HT-29 Cell Proliferation. [Thesis]. East Carolina University; 2013. Available from: http://hdl.handle.net/10342/4187

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Queens University

30. Turki, Razan. Increased calcium intake regulates colonic CaSR expression and inhibits induced colitis and Wnt/β-catenin signaling .

Degree: Physiology, 2012, Queens University

URL: http://hdl.handle.net/1974/7699

► One of the major complications in patients with long standing inflammatory bowel disease (IBD) is colitis-associated colon cancer. The signaling pathways that promote the transformation… (more)

▼ One of the major complications in patients with long standing inflammatory bowel disease (IBD) is colitis-associated colon cancer. The signaling pathways that promote the transformation of colitis to colorectal cancer (CRC) are unknown but one candidate is the prolonged interaction between tumor necrosis factor alpha (TNF-α) and its receptor, TNFR1. This interaction may stimulate a defective Wnt signaling pathway to evoke epithelial cells to hyperproliferate. This crypt hyperproliferation can lead to the development CRC. Activation of Extracellular Calcium-sensing receptor (CaSR) a G-protein coupled receptor, on sub-epithelial myfibroblasts has been found to stimulate the expression of Wnt5a, a member of Wnt family, while CaSR activation on the epithelial cells stimulates Wnt5a receptor, Ror2, a member of receptor tyrosine kinase family. Wnt5a/Ror2 (non canonical signaling) interaction has been suggested to decrease TNFR1 expression and inhibit Wnt/β-catenin signaling to regulate cellular growth. The aims of this thesis were to determine whether increased dietary calcium will increase colonic CaSR expression, characterize the colons of “rescued” CaSR/PTH double homozygous knockout and their response to an acute model of colitis, and assess whether CaSR activation influenced the status of Low-density lipoprotein receptor-related protein 6 (pLRP6), co-receptor for Wnt, in cell culture models. Our results demonstrated that CaSR expression is higher in the colon of the NIH-Swiss Webster mice after feeding them 2% calcium alone or in conjunction with vitamin D for four weeks compared to two weeks, suggesting that dietary calcium alone or together with vitamin D can regulate colonic CaSR expression. We found the CaSR-/PTH- colons had a significant reduction in the non canonical signaling and enhanced Wnt/β-catenin signaling and the amount of inflammation was increased, suggesting that CaSR can inhibit Wnt/β-catenin signaling in the colonic crypt and acts as an anti-inflammatory signal. Our results demonstrated that CaSR activation alone in CaSR-HEK and RKO cells reduced Wnt-stimulated LRP6 phosphorylation suggesting a crucial role of CaSR in the inhibition of LRP6 phosphorylation. The observations seen in this study strongly suggest a role for CaSR in inhibiting the defective Wnt/β-catenin signaling pathway, induced colitis, and LRP6 phosphorylation to regulate cellular growth.

Subjects/Keywords: Bowel disease; Colon cancer; Colitis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Turki, R. (2012). Increased calcium intake regulates colonic CaSR expression and inhibits induced colitis and Wnt/β-catenin signaling . (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/7699

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Turki, Razan. “Increased calcium intake regulates colonic CaSR expression and inhibits induced colitis and Wnt/β-catenin signaling .” 2012. Thesis, Queens University. Accessed November 16, 2018. http://hdl.handle.net/1974/7699.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Turki, Razan. “Increased calcium intake regulates colonic CaSR expression and inhibits induced colitis and Wnt/β-catenin signaling .” 2012. Web. 16 Nov 2018.

Vancouver:

Turki R. Increased calcium intake regulates colonic CaSR expression and inhibits induced colitis and Wnt/β-catenin signaling . [Internet] [Thesis]. Queens University; 2012. [cited 2018 Nov 16]. Available from: http://hdl.handle.net/1974/7699.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Turki R. Increased calcium intake regulates colonic CaSR expression and inhibits induced colitis and Wnt/β-catenin signaling . [Thesis]. Queens University; 2012. Available from: http://hdl.handle.net/1974/7699

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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Open Access Theses and Dissertations