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Vanderbilt University
1.
Tucker-Schwartz, Jason Michael.
Development of Photothermal Optical Coherence Tomography
for In Vivo Imaging of Contrast Agents.
Degree: PhD, Biomedical Engineering, 2015, Vanderbilt University
URL: http://hdl.handle.net/1803/13545 
► Sensitive and specific noninvasive in vivo imaging of contrast agents and endogenous molecules can supply molecular and functional information in animal models, providing essential insight…
(more)
▼ Sensitive and specific noninvasive in vivo
imaging of contrast agents and endogenous molecules can supply molecular and functional information in animal models, providing essential insight into mechanisms of disease formation and progression, drug delivery, and treatment response. In cancer in particular, high resolution
imaging is essential for capturing spatial heterogeneities in molecular expression and the tumor microenvironment that cause significant barriers to treatment efficacy and drug delivery. Optical
coherence tomography (OCT) fills the niche of cellular-level resolution and penetration depths in tissue that exceed those obtained with microscopy, an attractive regime for
imaging mouse models of cancer. In this dissertation, photothermal OCT (PTOCT), a functional extension of OCT, was developed for in vivo
imaging of a variety of contrast agents and drug delivery vectors in live animals. The PTOCT signal was thoroughly characterized in phantoms and compared to theory, followed by a demonstration of picomolar sensitivity to gold nanorod contrast agents. Gold nanorods at physiologically relevant concentrations were then identified from within a live mouse at depths exceeding the standard limits of high resolution optical microscopy. Then, heterogeneities in gold nanorod delivery to tumors were imaged in the context of tissue and vessel morphology, demonstrating the utility of PTOCT as part of a powerful multimodality
imaging platform for the development of nanomedicines and drug delivery technologies. The uptake of gold nanorods into mouse mammary tumors were tracked in three dimensions over 24 hours, and the specificity of the PTOCT signal was verified using multiphoton microscopy. Finally, photothermal optical lock-in optical
coherence tomography (poli-OCT) was used to increase system throughput and allow for real time photothermal
imaging. In vivo poli-OCT of indocyanine green identified lymphatic vessels in a mouse ear, and also identified picomolar concentrations of gold nanorods in subcutaneous injections at frame rates ten times faster than previously reported. Overall, the development of in vivo PTOCT combined with existing morphological and hemodynamic
imaging capabilities of OCT will enable more comprehensive studies of drug delivery and molecular expression in mouse models of disease, particularly cancer.
Advisors/Committee Members: Craig Duvall (committee member), Duco Jansen (committee member), Sharon Weiss (committee member), Tom Yankeelov (committee member), Melissa Skala (Committee Chair).
Subjects/Keywords: imaging; optical coherence tomography
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APA (6th Edition):
Tucker-Schwartz, J. M. (2015). Development of Photothermal Optical Coherence Tomography
for In Vivo Imaging of Contrast Agents. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/13545
Chicago Manual of Style (16th Edition):
Tucker-Schwartz, Jason Michael. “Development of Photothermal Optical Coherence Tomography
for In Vivo Imaging of Contrast Agents.” 2015. Doctoral Dissertation, Vanderbilt University. Accessed January 19, 2021.
http://hdl.handle.net/1803/13545.
MLA Handbook (7th Edition):
Tucker-Schwartz, Jason Michael. “Development of Photothermal Optical Coherence Tomography
for In Vivo Imaging of Contrast Agents.” 2015. Web. 19 Jan 2021.
Vancouver:
Tucker-Schwartz JM. Development of Photothermal Optical Coherence Tomography
for In Vivo Imaging of Contrast Agents. [Internet] [Doctoral dissertation]. Vanderbilt University; 2015. [cited 2021 Jan 19].
Available from: http://hdl.handle.net/1803/13545.
Council of Science Editors:
Tucker-Schwartz JM. Development of Photothermal Optical Coherence Tomography
for In Vivo Imaging of Contrast Agents. [Doctoral Dissertation]. Vanderbilt University; 2015. Available from: http://hdl.handle.net/1803/13545
Vanderbilt University
2.
Poole, Kristin Marie.
Quantitative optical imaging of vascular structure and function in a model of peripheral arterial disease.
Degree: MS, Biomedical Engineering, 2012, Vanderbilt University
URL: http://hdl.handle.net/1803/13329
► Peripheral arterial disease (PAD) leads to an increased risk of myocardial infarction and stroke, increased mortality, and reduced quality of life. The mouse hind limb…
(more)
▼ Peripheral arterial disease (PAD) leads to an increased risk of myocardial infarction and stroke, increased mortality, and reduced quality of life. The mouse hind limb ischemia (HLI) model is the most commonly used system for studying the mechanisms of collateral vessel formation and for testing new PAD therapies, but there is a lack of techniques for acquiring physiologically-relevant, quantitative data intravitally in this model. In this work, non-invasive, quantitative optical
imaging techniques were applied to the mouse HLI model over a time course. Quantification of hemoglobin oxygen saturation with hyperspectral
imaging was sensitive to changes in the oxygenation of the ischemic hind limb. Hemoglobin oxygen saturation measurements also correlated well with two standard measures of hind limb recovery: the perfusion ratio and probe-based tissue oxygen tension. Additionally, optical
coherence tomography (OCT) techniques were applied to study changes in blood flow with high resolution. Restoration of blood flow in vessels distal to the site of occlusion was monitored non-invasively with Doppler OCT. Three dimensional images of the adductor muscle acquired with Doppler OCT revealed changes in collateral vessel morphology consistent with post-mortem analyses in previous studies. This visualization of hind limb vasculature in a given mouse over time without contrast agents or post-mortem methods was previously unattainable. Taken together, hyperspectral
imaging and OCT enable acquisition of both functional and morphological data which fill the gaps in acquiring a complete picture of recovery in the mouse HLI model. Therefore, these optical
imaging methods hold promise as tools for studying the mechanisms of vascular recovery and evaluating novel therapeutic treatments in preclinical studies.
Advisors/Committee Members: Craig L. Duvall (Committee Chair), Melissa C. Skala (Committee Chair).
Subjects/Keywords: hyperspectral imaging; optical coherence tomography
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APA (6th Edition):
Poole, K. M. (2012). Quantitative optical imaging of vascular structure and function in a model of peripheral arterial disease. (Thesis). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/13329
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Poole, Kristin Marie. “Quantitative optical imaging of vascular structure and function in a model of peripheral arterial disease.” 2012. Thesis, Vanderbilt University. Accessed January 19, 2021.
http://hdl.handle.net/1803/13329.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Poole, Kristin Marie. “Quantitative optical imaging of vascular structure and function in a model of peripheral arterial disease.” 2012. Web. 19 Jan 2021.
Vancouver:
Poole KM. Quantitative optical imaging of vascular structure and function in a model of peripheral arterial disease. [Internet] [Thesis]. Vanderbilt University; 2012. [cited 2021 Jan 19].
Available from: http://hdl.handle.net/1803/13329.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Poole KM. Quantitative optical imaging of vascular structure and function in a model of peripheral arterial disease. [Thesis]. Vanderbilt University; 2012. Available from: http://hdl.handle.net/1803/13329
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
3.
Carrasco-Zevallos, Oscar M.
Development of Optical Coherence Tomography Systems for Ophthalmic Imaging and Intrasurgical Guidance
.
Degree: 2017, Duke University
URL: http://hdl.handle.net/10161/16296
► Ophthalmic microsurgery is one of the most commonly performed surgical procedures in the world and it necessitates precise three-dimensional manipulation of tissue at sub-millimeter…
(more)
▼ Ophthalmic microsurgery is one of the most commonly performed surgical procedures in the world and it necessitates precise three-dimensional manipulation of tissue at sub-millimeter spatial scales. As a result, ophthalmic surgeons require an operating microscope to perform surgery and to asses alterations to the tissue. Unfortunately, modern operating microscopes provide a limited en face perspective of the three-dimensional surgical field, and surgeons must infer depth information using stereoscopy and cannot directly visualize sub-surface anatomy. These limitations may compromise the surgeon’s ability to maneuver instruments axially and to comprehensively evaluate the three-dimensional tissue structure. Optical
coherence tomography (OCT) is a non-contact volumetric
imaging modality that is well suited to image the anterior and posterior human eye in vivo. The success of OCT in clinical ophthalmology motivated the development of intraoperative OCT to overcome the limitations of the operating microscope for ophthalmic surgery. However, current intraoperative OCT systems either require pauses in surgery for
imaging or are restricted to cross-sectional
imaging during surgery, thereby preventing OCT
imaging of live surgery that extends over three-dimensional space. This dissertation describes the design, development, and assessment of novel technologies for ophthalmic OCT
imaging and intrasurgical guidance. These technologies seek to address challenges associated with translating a biomedical
imaging device to the human operating suite and to improve upon current surgical visualization methods. We first describe eye tracking technologies designed to compensate for undesired
subject motion during retinal and anterior eye OCT
imaging. Next, we present a novel optical design for OCT retinal
imaging, demonstrate its use for pediatric
imaging, and discuss its advantages compared to conventional OCT retinal scanners. We then present the first 4D (volumetric
imaging over time) intraoperative OCT system capable of
imaging human ophthalmic surgery at up to 3 volumes/second. We report the results of a clinical study in which 4D intraoperative OCT was successfully used in >150 human eye surgeries. Next, we describe the optimization of an ultrahigh-speed OCT system using optical amplification and present a novel OCT scanning method designed for 4D
imaging. Finally, we present the preliminary design of a second-generation 4D intraoperative OCT system capable of
imaging surgical maneuvers at 15 volumes/second.
Advisors/Committee Members: Izatt, Joseph A (advisor).
Subjects/Keywords: Medical imaging;
ophthalmic imaging;
optical coherence tomography;
surgical imaging
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APA (6th Edition):
Carrasco-Zevallos, O. M. (2017). Development of Optical Coherence Tomography Systems for Ophthalmic Imaging and Intrasurgical Guidance
. (Thesis). Duke University. Retrieved from http://hdl.handle.net/10161/16296
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Carrasco-Zevallos, Oscar M. “Development of Optical Coherence Tomography Systems for Ophthalmic Imaging and Intrasurgical Guidance
.” 2017. Thesis, Duke University. Accessed January 19, 2021.
http://hdl.handle.net/10161/16296.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Carrasco-Zevallos, Oscar M. “Development of Optical Coherence Tomography Systems for Ophthalmic Imaging and Intrasurgical Guidance
.” 2017. Web. 19 Jan 2021.
Vancouver:
Carrasco-Zevallos OM. Development of Optical Coherence Tomography Systems for Ophthalmic Imaging and Intrasurgical Guidance
. [Internet] [Thesis]. Duke University; 2017. [cited 2021 Jan 19].
Available from: http://hdl.handle.net/10161/16296.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Carrasco-Zevallos OM. Development of Optical Coherence Tomography Systems for Ophthalmic Imaging and Intrasurgical Guidance
. [Thesis]. Duke University; 2017. Available from: http://hdl.handle.net/10161/16296
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Ryerson University
4.
Razani, Marjan.
Development of optical coherence tomography technique for clinical diagnostics and monitoring.
Degree: 2016, Ryerson University
URL: https://digital.library.ryerson.ca/islandora/object/RULA%3A5771
► This dissertation describes techniques that use Optical Coherence Tomography techniques developed for the detection of shear wave propagation in different phantoms, and the use of…
(more)
▼ This dissertation describes techniques that use Optical
Coherence Tomography techniques developed for the detection of shear wave propagation in different phantoms, and the use of such waves to enhance the transport of nanoparticles in tissue equivalent phantoms. In the first study, we explored the potential of measuring shear wave propagation using optical co-herence elastography (OCE) in an inhomogeneous phantom and carotid artery samples based on a swept source optical
coherence tomography (OCT) system. Shear waves were generated using a piezoelectric transducer transmitting sine-wave bursts of 400 μs duration, applying acoustic radiation force (ARF) to inhomogeneous phantoms and carotid artery samples, syn-chronized with a swept-source OCT (SS-OCT)
imaging system. The phantoms were com-posed of gelatin and titanium dioxide whereas the carotid artery samples were embedded in propagating shear waves in inhomogeneous tissue equivalent phantoms and carotid artery samples using the ARF of an ultrasound transducer, and measuring the shear wave speed and its associated properties in the different layers with OCT phase maps. In the second study, we present a technique to image the enhanced particle displacement generated using an acoustic radiation force (ARF) excitation source. A MEMS-VCSEL swept source Optical
Coherence Tomography (SS-OCT) system with a center wavelength of 1310 nm, a bandwidth of 100nm, and an A-scan rate of 100 kHz was used to detect gold nanoparticle displacement. ARF was applied after the nanoparticles diffused into a collagen matrix (of different collagen concen-trations and for a tissue engineered MCF-7 breast cancer cell construct). Differential OCT speckle variance images with and without the ARF were used to estimate the particle dis-placement. The images were used to detect the microscopic enhancement of nanoparticle displacement generated by the ARF. Using this OCT
imaging technique, the enhanced transport of particles though a collagen gel after using an ARF excitation was imaged and analysed.
Advisors/Committee Members: Kolios, Michael C. (Degree supervisor).
Subjects/Keywords: Optical Coherence Tomography; Optical amplifiers; Diognostic imaging
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APA (6th Edition):
Razani, M. (2016). Development of optical coherence tomography technique for clinical diagnostics and monitoring. (Thesis). Ryerson University. Retrieved from https://digital.library.ryerson.ca/islandora/object/RULA%3A5771
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Razani, Marjan. “Development of optical coherence tomography technique for clinical diagnostics and monitoring.” 2016. Thesis, Ryerson University. Accessed January 19, 2021.
https://digital.library.ryerson.ca/islandora/object/RULA%3A5771.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Razani, Marjan. “Development of optical coherence tomography technique for clinical diagnostics and monitoring.” 2016. Web. 19 Jan 2021.
Vancouver:
Razani M. Development of optical coherence tomography technique for clinical diagnostics and monitoring. [Internet] [Thesis]. Ryerson University; 2016. [cited 2021 Jan 19].
Available from: https://digital.library.ryerson.ca/islandora/object/RULA%3A5771.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Razani M. Development of optical coherence tomography technique for clinical diagnostics and monitoring. [Thesis]. Ryerson University; 2016. Available from: https://digital.library.ryerson.ca/islandora/object/RULA%3A5771
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Manchester
5.
Dinsdale, Graham.
Optical Coherence Tomography: applications and
developments for imaging in vivo biological tissue.
Degree: 2011, University of Manchester
URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:131341
► The work presented in this thesis was re-submitted to The University of Manchester for the degree of Doctor of Philosophy in July 2011 by Graham…
(more)
▼ The work presented in this thesis was re-submitted
to The University of Manchester for the degree of Doctor of
Philosophy in July 2011 by Graham Dinsdale and is entitled “Optical
Coherence Tomography: applications and developments for
imaging in
vivo biological tissue”.In this thesis the design and build of a
high-speed, video-rate optical
coherence tomography (OCT)
imaging
system is described. The system was designed for the purpose of
imaging human skin in vivo, particularly that of patients suffering
from conditions such as systemic sclerosis. Component selection and
design decisions are discussed in the context of the intended final
application. Initial test images from the system are presented. In
the context of building an OCT system, a supercontinuum light
source was characterised and tested for its suitability for use in
the OCT environment. Parameters such as
coherence length were
measured using simple interferometry techniques, while practical
considerations such as portability and ease of system integration
were also considered.Several applications of OCT
imaging techniques
were also investigated, using two commercially-available OCT
systems from Thorlabs, Inc. A liquid-based skin and blood flow
model was constructed using narrow glass capillary tubes, pumped
through with scattering solutions of Intralipid or suspensions of
polystyrene microspheres. The concentration of the solutions was
tuned by dilution in order to best model the scattering parameters
of blood. The model also used similar liquid solutions to model
static tissue surrounding the blood vessels. Doppler OCT images of
the model under various conditions were recorded, and velocity
profiles of the flowing liquids were extracted.Using the same
commercial OCT systems,
imaging over two separate wavelength
regions was also performed on the skin of several different species
of neo-tropical tree frog, some of which have interesting
reflective properties due to the presence of a pigment called
pterorhodin. Cross-sectional OCT images of the skin are presented,
and averaged depth profiles extracted from them. This is the first
time that OCT
imaging has been applied to this problem.A clinical
study of skin thickening and microvascular function in patients
with systemic sclerosis compared to healthy controls was also
carried out, again involving a Thorlabs, Inc. commercial OCT
system. This study was carried out at Salford Royal Hospital under
the supervision of the rheumatology research group. Skin thickness
was assessed using OCT and high-frequency ultrasound
imaging.
Microvascular function was measured using nailfold cappilaroscopy
and laser Doppler
imaging. Images from the study are presented
here.
Advisors/Committee Members: DICKINSON, MARK MR, MURRAY, ANDREA AK, Dickinson, Mark, Dickinson, Mark, Murray, Andrea, Murray, Andrea.
Subjects/Keywords: laser; broadband; OCT; coherence; imaging; tomography; optical
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Manager
APA (6th Edition):
Dinsdale, G. (2011). Optical Coherence Tomography: applications and
developments for imaging in vivo biological tissue. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:131341
Chicago Manual of Style (16th Edition):
Dinsdale, Graham. “Optical Coherence Tomography: applications and
developments for imaging in vivo biological tissue.” 2011. Doctoral Dissertation, University of Manchester. Accessed January 19, 2021.
http://www.manchester.ac.uk/escholar/uk-ac-man-scw:131341.
MLA Handbook (7th Edition):
Dinsdale, Graham. “Optical Coherence Tomography: applications and
developments for imaging in vivo biological tissue.” 2011. Web. 19 Jan 2021.
Vancouver:
Dinsdale G. Optical Coherence Tomography: applications and
developments for imaging in vivo biological tissue. [Internet] [Doctoral dissertation]. University of Manchester; 2011. [cited 2021 Jan 19].
Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:131341.
Council of Science Editors:
Dinsdale G. Optical Coherence Tomography: applications and
developments for imaging in vivo biological tissue. [Doctoral Dissertation]. University of Manchester; 2011. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:131341
Université Catholique de Louvain
6.
Mallat, Kamel.
Novel developments in Fourier domain optical coherence tomography and nonlinear tomographic interferometry.
Degree: 2014, Université Catholique de Louvain
URL: http://hdl.handle.net/2078.1/151822
► In this thesis we present novel methods to improve the limitations in Optical Coherence Tomography (OCT). They are divided into two parts. The first part…
(more)
▼ In this thesis we present novel methods to improve the limitations in Optical Coherence Tomography (OCT). They are divided into two parts. The first part deals with the axial resolution limitation in OCT systems. We give a description of the Fourier Domain OCT (FDOCT), and then we show theoretically how to enhance the axial resolution in a particular case of a two-layer sample where one of the two layers is moving continuously, while these two layers are separated by a distance lower than the physical axial resolution. The second part of the thesis demonstrates a novel full theoretical model that uses the second order autocorrelation interferometry technique in nonlinear optics to eliminate the strong background DC, and therefore enhance the imaging contrast. A femtosecond laser emits the light at 1300nm wavelength, it travels through a polarized beam splitter which divides the light in two orthogonal polarizations, one will probe the reference and the other will probe the sample. By realizing the second harmonic generation, in type II configuration, it is possible to eliminate the DC. The setup is adapted, in an original manner, so as to realize interferometric measurements on the sample arm using three waves coupling. A full description of the method with solid theoretical models justified by simulation and experimental results is presented in this part to validate the proof of concept. This part of the thesis shows the possibility to use non-linear interferometry in order to provide interferometric measurements on a dark field even if strong parasitic light is reflected by the sample.
(SC - Sciences) – UCL, 2014
Advisors/Committee Members: UCL - SST/IMCN/NAPS - Nanoscopic Physics, UCL - Faculté des Sciences, José Luis, Fernandez, Cornet, Alain, Urbain, Xavier, Piraux, Bernard, Francis, Laurent, Marc, Georges, Antoine, Philippe.
Subjects/Keywords: Interferometry; Optical coherence tomography; Nonlinear optic; Imaging
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APA (6th Edition):
Mallat, K. (2014). Novel developments in Fourier domain optical coherence tomography and nonlinear tomographic interferometry. (Thesis). Université Catholique de Louvain. Retrieved from http://hdl.handle.net/2078.1/151822
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Mallat, Kamel. “Novel developments in Fourier domain optical coherence tomography and nonlinear tomographic interferometry.” 2014. Thesis, Université Catholique de Louvain. Accessed January 19, 2021.
http://hdl.handle.net/2078.1/151822.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Mallat, Kamel. “Novel developments in Fourier domain optical coherence tomography and nonlinear tomographic interferometry.” 2014. Web. 19 Jan 2021.
Vancouver:
Mallat K. Novel developments in Fourier domain optical coherence tomography and nonlinear tomographic interferometry. [Internet] [Thesis]. Université Catholique de Louvain; 2014. [cited 2021 Jan 19].
Available from: http://hdl.handle.net/2078.1/151822.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Mallat K. Novel developments in Fourier domain optical coherence tomography and nonlinear tomographic interferometry. [Thesis]. Université Catholique de Louvain; 2014. Available from: http://hdl.handle.net/2078.1/151822
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Manchester
7.
Alwafi, Reem.
Development of optical coherence tomography endoscopy for gynaecological and gastrointestinal studies and peritoneal membrane imaging.
Degree: PhD, 2012, University of Manchester
URL: https://www.research.manchester.ac.uk/portal/en/theses/development-of-optical-coherence-tomography-endoscopy-for-gynaecological-and-gastrointestinal-studies-and-peritoneal-membrane-imaging(8254ec5d-549d-413a-a048-7d773e28dc79).html
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.727780
► In the medical field, the detection and diagnosis of diseases continue to improve. Developments in diagnostic techniques have helped to improve treatment in the early…
(more)
▼ In the medical field, the detection and diagnosis of diseases continue to improve. Developments in diagnostic techniques have helped to improve treatment in the early stages and avoid many risks to patients. One relatively new diagnostic technique is optical coherence tomography (OCT), which is used in many medical applications to perform internal microstructure imaging of the human body at high resolution (typically 10 micro metre), at high speed and in real time. OCT is non-invasive and can be used as a contact or non-contact technique to obtain an image. In medicine, there are many applications that involve OCT, such as in ophthalmology, gastroenterology, cardiology and oncology. This work demonstrates the design, development and implementation of a high resolution swept laser OCT system for the imaging and diagnosis of tissues in laboratory and clinical experiments. It reports an investigation to measure the thickness of the peritoneal membrane and the use of optical imaging contrast agents such as gold nanorods. There is also an account of the design of an endoscope-catheter fast scanning OCT system for biomedical studies of the gastrointestinal tract and gynaecological areas. These results were achieved by using a swept tuneable laser source with a very high tuning speed of 16 kHz over a wide range of wavelengths: 1260 nm to 1390 nm. The laser sweeps across 110 nm at a 16 kHz repetition rate. The real axial line speed is limited by the source that is used in the OCT system. The axial resolution of the system is 7 µm and its transverse resolution is 15 µm. The bandwidth of the source is up to DeltaGamma = 110 nm, centred at Gamma0 = 1325 nm, and the coherent length is 7 µm. On the sample arm of the interferometer, the swept laser OCT technique is combined with an optical probe and endoscope in order to develop a novel diagnostic imaging device to visualize tissue in vivo for animal and human experimental trials.
Subjects/Keywords: 616.07; Medical imaging techniques; Optical coherence tomography
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APA ·
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Manager
APA (6th Edition):
Alwafi, R. (2012). Development of optical coherence tomography endoscopy for gynaecological and gastrointestinal studies and peritoneal membrane imaging. (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/development-of-optical-coherence-tomography-endoscopy-for-gynaecological-and-gastrointestinal-studies-and-peritoneal-membrane-imaging(8254ec5d-549d-413a-a048-7d773e28dc79).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.727780
Chicago Manual of Style (16th Edition):
Alwafi, Reem. “Development of optical coherence tomography endoscopy for gynaecological and gastrointestinal studies and peritoneal membrane imaging.” 2012. Doctoral Dissertation, University of Manchester. Accessed January 19, 2021.
https://www.research.manchester.ac.uk/portal/en/theses/development-of-optical-coherence-tomography-endoscopy-for-gynaecological-and-gastrointestinal-studies-and-peritoneal-membrane-imaging(8254ec5d-549d-413a-a048-7d773e28dc79).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.727780.
MLA Handbook (7th Edition):
Alwafi, Reem. “Development of optical coherence tomography endoscopy for gynaecological and gastrointestinal studies and peritoneal membrane imaging.” 2012. Web. 19 Jan 2021.
Vancouver:
Alwafi R. Development of optical coherence tomography endoscopy for gynaecological and gastrointestinal studies and peritoneal membrane imaging. [Internet] [Doctoral dissertation]. University of Manchester; 2012. [cited 2021 Jan 19].
Available from: https://www.research.manchester.ac.uk/portal/en/theses/development-of-optical-coherence-tomography-endoscopy-for-gynaecological-and-gastrointestinal-studies-and-peritoneal-membrane-imaging(8254ec5d-549d-413a-a048-7d773e28dc79).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.727780.
Council of Science Editors:
Alwafi R. Development of optical coherence tomography endoscopy for gynaecological and gastrointestinal studies and peritoneal membrane imaging. [Doctoral Dissertation]. University of Manchester; 2012. Available from: https://www.research.manchester.ac.uk/portal/en/theses/development-of-optical-coherence-tomography-endoscopy-for-gynaecological-and-gastrointestinal-studies-and-peritoneal-membrane-imaging(8254ec5d-549d-413a-a048-7d773e28dc79).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.727780
University of Missouri – Columbia
8.
Zhang, Miao.
Towards high speed high sensitivity optical coherence tomography for in vivo functional imaging.
Degree: 2015, University of Missouri – Columbia
URL: http://hdl.handle.net/10355/47077
► [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Optical coherence tomography (OCT) is an imaging technique that has been widely used in…
(more)
▼ [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Optical
coherence tomography (OCT) is an
imaging technique that has been widely used in clinics and industrial fields. This dissertation, making use of several emerging techniques, works on improving the
imaging speed and sensitivity of current OCT systems so that it will be more powerful in
imaging biological tissues, live animals and human patients. Dual-band Fourier domain OCT (FD-OCT) has the potential to provide high quality images that can differentiate different types of tissues. However, previous dual-band FD-OCT systems could not give correct information due to inherited limitations in
imaging system setup, sample properties and theory. Our new
imaging system overcomes these limitations by using unique hardware and software design. In our
imaging system, different false signals are suppressed and the signal attenuation due to samples are compensated using proposed algorithms that derived from theoretical analysis. A video card is used to process data in an ultrahigh speed. With high
imaging speed we are able to
imaging live animals despite the movement of subjects. The high speed also makes it possible to display the
imaging volume interactively in 3D. The image quality and information contained in the images are improved. We further developed an OCT
imaging system using a special kind of optical beam called finite energy Airy beam. Compared to OCT system using traditional optical beams, Airy beam OCT has the potential to view a much longer range and view deeper inside the biological tissue.
Advisors/Committee Members: Yu, Ping (advisor).
Subjects/Keywords: Optical coherence tomography; Tissues – Imaging; Interferometry; Medicine
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APA (6th Edition):
Zhang, M. (2015). Towards high speed high sensitivity optical coherence tomography for in vivo functional imaging. (Thesis). University of Missouri – Columbia. Retrieved from http://hdl.handle.net/10355/47077
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Zhang, Miao. “Towards high speed high sensitivity optical coherence tomography for in vivo functional imaging.” 2015. Thesis, University of Missouri – Columbia. Accessed January 19, 2021.
http://hdl.handle.net/10355/47077.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Zhang, Miao. “Towards high speed high sensitivity optical coherence tomography for in vivo functional imaging.” 2015. Web. 19 Jan 2021.
Vancouver:
Zhang M. Towards high speed high sensitivity optical coherence tomography for in vivo functional imaging. [Internet] [Thesis]. University of Missouri – Columbia; 2015. [cited 2021 Jan 19].
Available from: http://hdl.handle.net/10355/47077.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Zhang M. Towards high speed high sensitivity optical coherence tomography for in vivo functional imaging. [Thesis]. University of Missouri – Columbia; 2015. Available from: http://hdl.handle.net/10355/47077
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Duke University
9.
Li, You.
Coherent flow power Doppler imaging
.
Degree: 2017, Duke University
URL: http://hdl.handle.net/10161/16377
► Ultrasonic flow detection is a widely used technique to detect vessel, measure blood flow velocities, and monitor perfusion. Conventional techniques include color Doppler imaging…
(more)
▼ Ultrasonic flow detection is a widely used technique to detect vessel, measure blood flow velocities, and monitor perfusion. Conventional techniques include color Doppler
imaging and power Doppler (PD)
imaging. These methods depend on either the measurement of phase change or the detection of the power of backscattered echoes from blood. Both techniques are susceptible to noise. Common noise sources include thermal noise and clutter. The noise significantly deteriorates the performance of color Doppler
imaging, because color Doppler
imaging estimates the axial blood velocity from temporal changes in the echo phase, and phase change measurement is sensitive to noise. Power Doppler
imaging measures the power of the temporal differences in backscattered echoes, and can provide higher sensitivity with small vessel and slow flow detection than color Doppler
imaging at the expense of direction and velocity information. However, it requires a large ensemble length, limiting the frame rate to a few frames per second. The limitations of color Doppler
imaging and power Doppler
imaging are more severe in deep body vessel
imaging due to depth dependent attenuation of the ultrasound waves. Therefore, for deep body vessel
imaging, including liver vessel
imaging and placental spiral artery
imaging, better vessel detection techniques are desirable. Coherent flow power Doppler (CFPD)
imaging was proposed as a sensitive flow detection and
imaging technique for slow flow and small vessels. In this work, we present the study on CFPD from principles to clinical evaluation. The CFPD
imaging technique detects blood flow from the spatial
coherence of the blood signal. The short-lag spatial
coherence (SLSC) beamformer is used for the measurement of spatial
coherence. Because blood signals and common noise sources, including thermal noise reverberation clutter, have different spatial
coherence properties, CFPD can suppress the noise. The performance of CFPD in flow detection was evaluated with simulations and flow phantom experiments under various
imaging conditions, and compared with the performance of PD. It is found that CFPD provides an improvement of Doppler signal-to-noise ratio (SNR) of 7.5-12.5 dB over PD in slow flow and small vessel
imaging. The improvement in SNR translates to higher Doppler image contrast, faster frame rate, or lower limit-of-detection (LOD). In similar
imaging conditions of slow flow, CFPD may detect up to 50% slower flow than PD. The CFPD
imaging technique was also implemented with novel pulse sequences, including plane-wave synthetic transmit aperture
imaging, and diverging-wave synthetic transmit aperture
imaging. For plane-wave synthetic transmit aperture
imaging, the angular
coherence theory was proposed to describe the
coherence of backscattered waves corresponding to plane wave transmits at different steering angles. In addition, we also propose the coherent Kasai and Loupas estimators, which utilizes the
coherence information of flow signals to provide velocity estimates with…
Advisors/Committee Members: Dahl, Jeremy (advisor), Trahey, Gregg (advisor).
Subjects/Keywords: Medical imaging;
Acoustics;
Medicine;
coherence;
Doppler;
Ultrasound
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APA (6th Edition):
Li, Y. (2017). Coherent flow power Doppler imaging
. (Thesis). Duke University. Retrieved from http://hdl.handle.net/10161/16377
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Li, You. “Coherent flow power Doppler imaging
.” 2017. Thesis, Duke University. Accessed January 19, 2021.
http://hdl.handle.net/10161/16377.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Li, You. “Coherent flow power Doppler imaging
.” 2017. Web. 19 Jan 2021.
Vancouver:
Li Y. Coherent flow power Doppler imaging
. [Internet] [Thesis]. Duke University; 2017. [cited 2021 Jan 19].
Available from: http://hdl.handle.net/10161/16377.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Li Y. Coherent flow power Doppler imaging
. [Thesis]. Duke University; 2017. Available from: http://hdl.handle.net/10161/16377
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Manchester
10.
Alwafi, Reem Odah S.
Development of Optical Coherence Tomography Endoscopy for
Gynaecological and Gastrointestinal Studies and Peritoneal Membrane
Imaging.
Degree: 2012, University of Manchester
URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:166397
► In the medical field, the detection and diagnosis of diseases continue to improve. Developments in diagnostic techniques have helped to improve treatment in the early…
(more)
▼ In the medical field, the detection and diagnosis
of diseases continue to improve. Developments in diagnostic
techniques have helped to improve treatment in the early stages and
avoid many risks to patients. One relatively new diagnostic
technique is optical coherence tomography (OCT), which is used in
many medical applications to perform internal microstructure
imaging of the human body at high resolution (typically 10 μm), at
high speed and in real time. OCT is non-invasive and can be used as
a contact or non-contact technique to obtain an image. In medicine,
there are many applications that involve OCT, such as in
ophthalmology, gastroenterology, cardiology and oncology. This work
demonstrates the design, development and implementation of a high
resolution swept laser OCT system for the imaging and diagnosis of
tissues in laboratory and clinical experiments. It reports an
investigation to measure the thickness of the peritoneal membrane
and the use of optical imaging contrast agents such as gold
nanorods. There is also an account of the design of an
endoscope-catheter fast scanning OCT system for biomedical studies
of the gastrointestinal tract and gynaecological areas. These
results were achieved by using a swept tuneable laser source with a
very high tuning speed of 16 kHz over a wide range of wavelengths:
1260 nm to 1390 nm. The laser sweeps across 110 nm at a 16 kHz
repetition rate. The real axial line speed is limited by the source
that is used in the OCT system. The axial resolution of the system
is 7 µm and its transverse resolution is 15 µm. The bandwidth of
the source is up to Δλ = 110 nm, centred at λ0 = 1325 nm, and the
coherent length is 7 µm. On the sample arm of the interferometer,
the swept laser OCT technique is combined with an optical probe and
endoscope in order to develop a novel diagnostic imaging device to
visualize tissue in vivo for animal and human experimental
trials.
In the medical field, the detection and diagnosis
of diseases continue to improve. Developments in diagnostic
techniques have helped to improve treatment in the early stages and
avoid many risks to patients. One relatively new diagnostic
technique is optical coherence tomography (OCT), which is used in
many medical applications to perform internal microstructure
imaging of the human body at high resolution (typically 10 μm), at
high speed and in real time. OCT is non-invasive and can be used as
a contact or non-contact technique to obtain an image. In medicine,
there are many applications that involve OCT, such as in
ophthalmology, gastroenterology, cardiology and oncology. This work
demonstrates the design, development and implementation of a high
resolution swept laser OCT system for the imaging and diagnosis of
tissues in laboratory and clinical experiments. It reports an
investigation to measure the thickness of the peritoneal membrane
and the use of optical imaging contrast agents such as gold
nanorods. There is also an account of the design of an
endoscope-catheter fast scanning OCT system for biomedical studies
of…
Advisors/Committee Members: Dickinson, Mark.
Subjects/Keywords: Medical imaging techniques; Optical coherence
tomography
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APA ·
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to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Alwafi, R. O. S. (2012). Development of Optical Coherence Tomography Endoscopy for
Gynaecological and Gastrointestinal Studies and Peritoneal Membrane
Imaging. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:166397
Chicago Manual of Style (16th Edition):
Alwafi, Reem Odah S. “Development of Optical Coherence Tomography Endoscopy for
Gynaecological and Gastrointestinal Studies and Peritoneal Membrane
Imaging.” 2012. Doctoral Dissertation, University of Manchester. Accessed January 19, 2021.
http://www.manchester.ac.uk/escholar/uk-ac-man-scw:166397.
MLA Handbook (7th Edition):
Alwafi, Reem Odah S. “Development of Optical Coherence Tomography Endoscopy for
Gynaecological and Gastrointestinal Studies and Peritoneal Membrane
Imaging.” 2012. Web. 19 Jan 2021.
Vancouver:
Alwafi ROS. Development of Optical Coherence Tomography Endoscopy for
Gynaecological and Gastrointestinal Studies and Peritoneal Membrane
Imaging. [Internet] [Doctoral dissertation]. University of Manchester; 2012. [cited 2021 Jan 19].
Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:166397.
Council of Science Editors:
Alwafi ROS. Development of Optical Coherence Tomography Endoscopy for
Gynaecological and Gastrointestinal Studies and Peritoneal Membrane
Imaging. [Doctoral Dissertation]. University of Manchester; 2012. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:166397
Duke University
11.
Viehland, Christian Blake.
Development of Optical Coherence Tomography Systems for Intrasurgical and Pediatric Imaging
.
Degree: 2018, Duke University
URL: http://hdl.handle.net/10161/18275
► Optical coherence tomography (OCT) is a non-contact imaging modality that provides micron scale resolution of in-vivo tissue. Due to these characteristics, OCT is the…
(more)
▼ Optical
coherence tomography (OCT) is a non-contact
imaging modality that provides micron scale resolution of in-vivo tissue. Due to these characteristics, OCT is the clinical standard of care in ophthalmology for the diagnosis and monitoring of ocular diseases. Despite its success in adult clinical ophthalmology, OCT has seen more limited use in other ophthalmic specialties including pediatrics and surgery. This is primarily due to the fact that most commercially available OCT systems are large, tabletop systems that require a compliant seated
subject. This limits their utility in
imaging non-cooperative, supine subjects such as patients undergoing surgery and infants in the nursery. The works presented in this dissertation describe the development and translation of several OCT systems specialized for intrasurgical and pediatric
imaging. The first system presented is a microscope integrated OCT system that provided, for the first time, ever live 4D (3D over time)
imaging of retinal microsurgery. We present techniques for visualization of real-time intrasurgical OCT data (chapter 2) and summary
imaging results from mock surgeries in the wet lab and over 150 surgeries in the human ophthalmic operating room (chapter 3). For pediatric
imaging we present two novel handheld OCT systems for point of care
imaging of infants in the nursery. The first is the lightest handheld OCT system ever reported. We show
imaging results from the intensive care nursery that demonstrate the ability of this system to image pediatric pathology and retinal development (chapter 5). The second system is faster handheld OCT probe that features a novel optical and ergonomic design (chapter 6). We present initial results from the translation of this system into the nursery. OCT angiography (OCTA) is an emerging functional extension of OCT that leverages the high speed of modern OCT systems to allow for non-invasive
imaging of the retinal microvasculature. The final aim of this dissertation reports on the use of the microscope integrated OCT system and the high speed handheld OCT system for OCTA (chapters 4 and 6 respectively). To the best of knowledge the handheld OCTA images described in this manuscript are the first handheld OCTA images taken of an awake infant.
Advisors/Committee Members: Izatt, Joseph A (advisor).
Subjects/Keywords: Biomedical engineering;
Intrasurgical Imaging;
Optical Coherence Tomography;
Optical Coherence Tomography Angiography;
Pediatric Imaging
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Manager
APA (6th Edition):
Viehland, C. B. (2018). Development of Optical Coherence Tomography Systems for Intrasurgical and Pediatric Imaging
. (Thesis). Duke University. Retrieved from http://hdl.handle.net/10161/18275
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Viehland, Christian Blake. “Development of Optical Coherence Tomography Systems for Intrasurgical and Pediatric Imaging
.” 2018. Thesis, Duke University. Accessed January 19, 2021.
http://hdl.handle.net/10161/18275.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Viehland, Christian Blake. “Development of Optical Coherence Tomography Systems for Intrasurgical and Pediatric Imaging
.” 2018. Web. 19 Jan 2021.
Vancouver:
Viehland CB. Development of Optical Coherence Tomography Systems for Intrasurgical and Pediatric Imaging
. [Internet] [Thesis]. Duke University; 2018. [cited 2021 Jan 19].
Available from: http://hdl.handle.net/10161/18275.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Viehland CB. Development of Optical Coherence Tomography Systems for Intrasurgical and Pediatric Imaging
. [Thesis]. Duke University; 2018. Available from: http://hdl.handle.net/10161/18275
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Manitoba
12.
Thanusutiyabhorn, Pimrapat.
Spectroscopic imaging using quadrature optical coherence tomography.
Degree: Electrical and Computer Engineering, 2014, University of Manitoba
URL: http://hdl.handle.net/1993/23940
► Optical Coherence Tomography (OCT) is a subsurface imaging technique with many biomedical and industrial applications. In this thesis, we describe our design and implementation of…
(more)
▼ Optical
Coherence Tomography (OCT) is a subsurface
imaging technique with many biomedical and industrial applications. In this thesis, we describe our design and implementation of a time domain OCT system. We used this system to obtain OCT images of objects that are important in different applications. We also used an existing quadrature OCT system to obtain both real and imaginary parts of an OCT image. We introduced a new interpretation of OCT images as the 2nd derivative of the scattering potential of an object. To obtain this scattering potential from its 2nd derivative, we implemented a method of definite integration in the spectral-domain. The obtained scattering potential was used to separate the scattering profile from the absorption profile of an object. We applied this new spectroscopic
imaging method to quadrature OCT images of different objects.
Advisors/Committee Members: Sherif, Sherif (Electrical and Computer Engineering) (supervisor), Major, Arkady (Electrical and Computer Engineering) Paliwal, Jitendra (Biosystems Engineering) (examiningcommittee).
Subjects/Keywords: Spectroscopic imaging; Optical coherence tomography; Quadrature interferometer; Biomedical imaging
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Manager
APA (6th Edition):
Thanusutiyabhorn, P. (2014). Spectroscopic imaging using quadrature optical coherence tomography. (Masters Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/23940
Chicago Manual of Style (16th Edition):
Thanusutiyabhorn, Pimrapat. “Spectroscopic imaging using quadrature optical coherence tomography.” 2014. Masters Thesis, University of Manitoba. Accessed January 19, 2021.
http://hdl.handle.net/1993/23940.
MLA Handbook (7th Edition):
Thanusutiyabhorn, Pimrapat. “Spectroscopic imaging using quadrature optical coherence tomography.” 2014. Web. 19 Jan 2021.
Vancouver:
Thanusutiyabhorn P. Spectroscopic imaging using quadrature optical coherence tomography. [Internet] [Masters thesis]. University of Manitoba; 2014. [cited 2021 Jan 19].
Available from: http://hdl.handle.net/1993/23940.
Council of Science Editors:
Thanusutiyabhorn P. Spectroscopic imaging using quadrature optical coherence tomography. [Masters Thesis]. University of Manitoba; 2014. Available from: http://hdl.handle.net/1993/23940
University of Toronto
13.
Cheng, Ho Yiu.
Speckle And Motion Based Vascular Image Analysis for Optical Coherence Tomography.
Degree: PhD, 2015, University of Toronto
URL: http://hdl.handle.net/1807/69271
► Optical Coherence Tomography (OCT) is an emerging optical imaging modality that is capable of imaging biological tissues with micron resolution and millimeter penetration depth. In…
(more)
▼ Optical
Coherence Tomography (OCT) is an emerging optical
imaging modality that is capable of
imaging biological tissues with micron resolution and millimeter penetration depth. In clinical diagnostic
imaging and pathology, OCT has helped fill a gap in terms of both resolution and
imaging depth, in between traditional fluoroescence based microscopes and non-invasive organ level
imaging. In this domain, OCT can be used both as an ex vivo pathological examination tool or in vivo
imaging modality.OCT has been successful in ophthalmology owing to its excellent in vivo optical sectioning ability and penetration depth. Over the years, OCT has seen substantial progress in terms of application diversification and functionalities. In addition to being able to image more organs and tissues, OCT has been configured to be incorporated inside catheters, enabling wall structure
imaging in luminal settings, for example, major blood vessels or the digestive tract. And other than anatomical structures, OCT has also been able to specifically map out flow or elasticity.As OCT becomes more diversified, data obtained also become more diversified in terms of information but more complicated. For instance, in endovascular OCT (EV-OCT), data were acquired radially instead of the traditional raster scanning. Moreover, during the pullback scanning in EV-OCT, motion artefacts are severe and this restricts the amount of functional information to be obtained. Furthermore, as OCT
imaging speed becomes faster, reaching as high as 3.2 MHz axial scan rate, flow
imaging is obliged to undergo paradigm shift, particularly from conventional ultrasound practices.The main goal of this thesis was to address the development and validation of a set of algorithms that tackle these problems we now face in modern OCT systems and increase the utility of information obtained. In this thesis, an experimental protocol was first developed for proper porcine carotid arterial EV-OCT
imaging. The data obtained were then utilized for the first time to dynamically detect microvessels (vasa vasorum) in major arterial wall. Meanwhile optimized digital speckle noise removal was performed for the first time on Fourier domain EV-OCT system data to further facilitate vessel wall evaluation and microvessel detection. Lastly, a novel depth enhanced OCT microangiography algorithm was devised for in vivo microvascular
imaging of malformed vascular networks of human skin with genetic origins for the first time. The significance of this thesis lies in the potential of helping better understand the mechanism, progression and the effect of therapeutic intervention on various vascular diseases such as atherosclerosis and hereditary hemorrhagic telangiectasia. Better preventive measures and treatment options can ultimately be devised with advanced understanding of vascular diseases formation.
Advisors/Committee Members: Herman, Peter R, Yang, Victor, Electrical and Computer Engineering.
Subjects/Keywords: Endovascular Imaging; Microvascular Imaging; Optical Coherence Tomography; Speckle; 0544
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APA (6th Edition):
Cheng, H. Y. (2015). Speckle And Motion Based Vascular Image Analysis for Optical Coherence Tomography. (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/69271
Chicago Manual of Style (16th Edition):
Cheng, Ho Yiu. “Speckle And Motion Based Vascular Image Analysis for Optical Coherence Tomography.” 2015. Doctoral Dissertation, University of Toronto. Accessed January 19, 2021.
http://hdl.handle.net/1807/69271.
MLA Handbook (7th Edition):
Cheng, Ho Yiu. “Speckle And Motion Based Vascular Image Analysis for Optical Coherence Tomography.” 2015. Web. 19 Jan 2021.
Vancouver:
Cheng HY. Speckle And Motion Based Vascular Image Analysis for Optical Coherence Tomography. [Internet] [Doctoral dissertation]. University of Toronto; 2015. [cited 2021 Jan 19].
Available from: http://hdl.handle.net/1807/69271.
Council of Science Editors:
Cheng HY. Speckle And Motion Based Vascular Image Analysis for Optical Coherence Tomography. [Doctoral Dissertation]. University of Toronto; 2015. Available from: http://hdl.handle.net/1807/69271
Virginia Tech
14.
Shang, Ruibo.
Spectral domain interferometry: A high-sensitivity, high-speed approach to quantitative phase imaging.
Degree: MS, Electrical Engineering, 2015, Virginia Tech
URL: http://hdl.handle.net/10919/54001
► Many biological specimens are transparent and in weak intensity contrast, making it invisible using conventional bright field microscopes. Therefore, the phase-based optical microscopy techniques play…
(more)
▼ Many biological specimens are transparent and in weak intensity contrast, making it invisible using conventional bright field microscopes. Therefore, the phase-based optical microscopy techniques play important roles in the development of the modern biomedical science. Furthermore, the ability to achieve quantitative phase measurement of the tiny structures of biomedical specimens is of great importance for many biomedical applications. Thus, quantitative phase
imaging becomes an important technique to measure the phase variations due to the difference of refractive index and geometric thickness of various structures and materials within the biomedical specimens.
In this thesis, a spectral modulation interferometry (SMI) is developed to achieve quantitative phase
imaging. In SMI, the phase and amplitude information will simultaneously be modulated onto the interference spectrum of the broadband light. Full-field phase images can be obtained by scanning along the orthogonal direction only. SMI incorporates the advantages of low
coherence from broadband light source, high sensitivity from spectral domain interferometry and the high speed from the spectral modulation technique to achieve quantitative phase measurement with free of speckle, high temporal sensitivity (~0.1nm) and fast
imaging rate. The principles of SMI system and programming as well as some important image processing methods will be discussed in detail. Besides, the quantitative phase measurement of the reflective object (USAF resolution target) and the transmitted biological objects (Peranema, human cheek cells) will be shown.
Advisors/Committee Members: Zhu, Yizheng (committeechair), Xu, Yong (committee member), Agah, Masoud (committee member).
Subjects/Keywords: Interference microscopy; Interferometric imaging; Coherence imaging; Phase measurement
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APA (6th Edition):
Shang, R. (2015). Spectral domain interferometry: A high-sensitivity, high-speed approach to quantitative phase imaging. (Masters Thesis). Virginia Tech. Retrieved from http://hdl.handle.net/10919/54001
Chicago Manual of Style (16th Edition):
Shang, Ruibo. “Spectral domain interferometry: A high-sensitivity, high-speed approach to quantitative phase imaging.” 2015. Masters Thesis, Virginia Tech. Accessed January 19, 2021.
http://hdl.handle.net/10919/54001.
MLA Handbook (7th Edition):
Shang, Ruibo. “Spectral domain interferometry: A high-sensitivity, high-speed approach to quantitative phase imaging.” 2015. Web. 19 Jan 2021.
Vancouver:
Shang R. Spectral domain interferometry: A high-sensitivity, high-speed approach to quantitative phase imaging. [Internet] [Masters thesis]. Virginia Tech; 2015. [cited 2021 Jan 19].
Available from: http://hdl.handle.net/10919/54001.
Council of Science Editors:
Shang R. Spectral domain interferometry: A high-sensitivity, high-speed approach to quantitative phase imaging. [Masters Thesis]. Virginia Tech; 2015. Available from: http://hdl.handle.net/10919/54001
University of Illinois – Urbana-Champaign
15.
South, Fredrick A.
Computational optical coherence tomography for polarization-sensitive imaging, aberration correction, and wavefront measurement.
Degree: PhD, Electrical & Computer Engr, 2018, University of Illinois – Urbana-Champaign
URL: http://hdl.handle.net/2142/101127
► In this thesis, multiple longstanding challenges in optical imaging are solved by the development of new computational imaging methods, where computational imaging does not simply…
(more)
▼ In this thesis, multiple longstanding challenges in optical
imaging are solved by the development of new computational
imaging methods, where computational
imaging does not simply refer to simulation or modeling, but to the entirety of an
imaging technology in which significant computation is required to achieve the final image. Of the many optical
imaging technologies currently in use, optical
coherence tomography (OCT) is distinctive in that it provides coherent measurement of optical scattering within bulk biological tissue. Unfortunately, the optical wavefront is often distorted by defocus and aberration, from either the
imaging system or the sample itself, leading to poor image quality. Through a careful consideration of the optical theory and
imaging hardware, computational
imaging methods can correct these distortions through creative data acquisition and processing schemes. Here, new computational OCT methods are developed from theory to implementation to address three related challenges in optical
imaging. First, computational OCT is extended to polarization-sensitive
imaging. This provides the improved resolution and
imaging depth of computational OCT with the enhanced contrast of polarization-sensitive
imaging. Second, computational OCT is combined with hardware-based wavefront correction. This addresses the low signal-to-noise ratio (SNR) limitation of computational OCT and provides improved performance beyond that of hardware-only correction. Lastly, distortion of the optical wavefront is computationally measured directly from the OCT data. This enables both measurement and correction of the optical wavefront throughout biological samples without additional hardware. Together, these results demonstrate the usefulness of computational OCT across a broad range of important
imaging scenarios in biology and medicine.
Advisors/Committee Members: Boppart, Stephen A. (advisor), Boppart, Stephen A. (Committee Chair), Carney, P Scott (committee member), Eden, J Gary (committee member), Gao, Liang (committee member).
Subjects/Keywords: optics; imaging; computational imaging; optical coherence tomography; adaptive optics; optical aberrations; coherent imaging
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APA (6th Edition):
South, F. A. (2018). Computational optical coherence tomography for polarization-sensitive imaging, aberration correction, and wavefront measurement. (Doctoral Dissertation). University of Illinois – Urbana-Champaign. Retrieved from http://hdl.handle.net/2142/101127
Chicago Manual of Style (16th Edition):
South, Fredrick A. “Computational optical coherence tomography for polarization-sensitive imaging, aberration correction, and wavefront measurement.” 2018. Doctoral Dissertation, University of Illinois – Urbana-Champaign. Accessed January 19, 2021.
http://hdl.handle.net/2142/101127.
MLA Handbook (7th Edition):
South, Fredrick A. “Computational optical coherence tomography for polarization-sensitive imaging, aberration correction, and wavefront measurement.” 2018. Web. 19 Jan 2021.
Vancouver:
South FA. Computational optical coherence tomography for polarization-sensitive imaging, aberration correction, and wavefront measurement. [Internet] [Doctoral dissertation]. University of Illinois – Urbana-Champaign; 2018. [cited 2021 Jan 19].
Available from: http://hdl.handle.net/2142/101127.
Council of Science Editors:
South FA. Computational optical coherence tomography for polarization-sensitive imaging, aberration correction, and wavefront measurement. [Doctoral Dissertation]. University of Illinois – Urbana-Champaign; 2018. Available from: http://hdl.handle.net/2142/101127
Duke University
16.
Long, Willie Jie.
Backscatter Spatial Coherence for Ultrasonic Image Quality Characterization: Theory and Applications
.
Degree: 2020, Duke University
URL: http://hdl.handle.net/10161/21045
► Adaptive ultrasound systems, designed to automatically and dynamically tune imaging parameters based on image quality feedback, represent a promising solution for reducing the user-dependence…
(more)
▼ Adaptive ultrasound systems, designed to automatically and dynamically tune
imaging parameters based on image quality feedback, represent a promising solution for reducing the user-dependence of ultrasound. The efficacy of such systems, however, depends on the ability to accurately and reliably measure in vivo image quality with minimal user interaction – a task for which existing image quality metrics are ill-suited. This dissertation explores the application of backscatter spatial
coherence as an alternative image quality metric for adaptive
imaging. Adaptive ultrasound methods applying spatial
coherence feedback are evaluated in the context of three different applications: 1) the automated selection of acoustic output, 2) model-based clutter suppression in B-mode
imaging, and 3) adaptive wall filtering in color flow
imaging. A novel image quality metric, known as the lag-one
coherence (LOC), was introduced along with the theory that relates LOC to channel noise and the conventional image quality metrics of contrast and contrast-to-noise ratio (CNR). Simulation studies were performed to validate this theory and compare the variability of LOC to that of conventional metrics. In addition, matched measurements of LOC, contrast, CNR, and temporal correlation were obtained from harmonic phantom and liver images formed with varying mechanical index (MI) to assess the feasibility of adaptive acoustic output selection using LOC feedback. Measurements of LOC in simulation and phantom demonstrated lower variability in LOC relative to contrast and CNR over a wide range of clinically-relevant noise levels. This improved stability was supported by in vivo measurements of LOC that showed increased monotonicity with changes in MI compared to matched measurements of contrast and CNR (88.6% and 85.7% of acquisitions, respectively). The sensitivity of LOC to temporally-stable acoustic noise was evidenced by positive correlations between LOC and contrast (r=0.74) and LOC and CNR (r=0.66) at high acoustic output levels in the absence of thermal noise. Together, these properties translated to repeatable characterization of patient-specific trends in image quality that were able to demonstrate feasibility for the automated selection of acoustic output using LOC and its application for in vivo image quality feedback. In a second study, a novel model-based adaptive
imaging method called Lag-one Spatial
Coherence Adaptive Normalization, or LoSCAN, was explored as a means to locally estimate and compensate for the contribution of spatially incoherent clutter from conventional delay-and-sum (DAS) images using measurements of LOC. Suppression of incoherent clutter by LoSCAN resulted in improved image quality without introducing many of the artifacts common to other
coherence-based beamforming methods. In simulations with known targets and added channel noise, LoSCAN was shown to restore native contrast and increase DAS dynamic range by as much as 10-15 dB. These improvements were accompanied by DAS-like speckle texture along…
Advisors/Committee Members: Trahey, Gregg E (advisor).
Subjects/Keywords: Medical imaging;
Adaptive Imaging;
Clutter;
Color Flow Imaging;
Image Quality;
Spatial Coherence;
Ultrasound
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APA (6th Edition):
Long, W. J. (2020). Backscatter Spatial Coherence for Ultrasonic Image Quality Characterization: Theory and Applications
. (Thesis). Duke University. Retrieved from http://hdl.handle.net/10161/21045
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Long, Willie Jie. “Backscatter Spatial Coherence for Ultrasonic Image Quality Characterization: Theory and Applications
.” 2020. Thesis, Duke University. Accessed January 19, 2021.
http://hdl.handle.net/10161/21045.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Long, Willie Jie. “Backscatter Spatial Coherence for Ultrasonic Image Quality Characterization: Theory and Applications
.” 2020. Web. 19 Jan 2021.
Vancouver:
Long WJ. Backscatter Spatial Coherence for Ultrasonic Image Quality Characterization: Theory and Applications
. [Internet] [Thesis]. Duke University; 2020. [cited 2021 Jan 19].
Available from: http://hdl.handle.net/10161/21045.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Long WJ. Backscatter Spatial Coherence for Ultrasonic Image Quality Characterization: Theory and Applications
. [Thesis]. Duke University; 2020. Available from: http://hdl.handle.net/10161/21045
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
17.
Zafar, Haroon.
Development and applications of optical imaging techniques for microcirculation and cardiovascular imaging
.
Degree: 2016, National University of Ireland – Galway
URL: http://hdl.handle.net/10379/5962
► The work presented in this thesis describes the development and applications of optical imaging techniques, optical coherence tomography (OCT) and photoacoustic (PA) imaging, for the…
(more)
▼ The work presented in this thesis describes the development and applications of optical
imaging techniques, optical
coherence tomography (OCT) and photoacoustic (PA)
imaging, for the purpose of diagnosing and treating diseases which are related to the microcirculation, skin conditions and the cardiovascular system.
The feasibility of correlation mapping OCT (cmOCT) for in vivo
imaging of human microcirculation under diseased conditions was demonstrated. The cmOCT technique uses standard OCT image acquisition and post processing software based on correlation statistics. cmOCT was used for in vivo microcirculation
imaging of human forearm under normal and psoriatic conditions. The cmOCT technique has been found promising in terms of sensitivity and computational time for in vivo microcirculation
imaging beneath human skin under normal and diseased conditions. The cmOCT generated microcirculation maps of the healthy tissue and psoriatic plaque provide adequate resolution in a totally non-invasive manner. The presented results indicate that cmOCT allows not only the identification of the microvessels, but also produces more detailed microvascular networks showing how the blood vessels relate to each other in healthy tissue and within the plaque. The feasibility of intra-coronary OCT correlation mapping to investigate the role of coronary microvessels in human atherosclerosis was also studied.
A pre-clinical combined PA and ultrasound (US)
imaging system, based on a multi-element linear-array transducer combined with multichannel collecting system, was optimised for human
imaging under normal and diseased conditions. In vivo 3D co-registered PA/US structural and functional images from different sites within human skin such as forearm, breast and carotid were obtained using a range of high frequency transducer probes (15 MHz to 40 MHz). The linear-array based PA
imaging has been found promising in terms of resolution,
imaging depth and
imaging speed for clinical applications. However, significant challenges remain, particularly with the
imaging depth. High frequency linear-array transducer probes used in this study are similar in style, shape and use to regular hand-held clinical ultrasound probes, which can easily be acoustically coupled to the skin and moved around while
imaging in real time. We believe that a reflection type probe used in this study is most likely to succeed in clinical applications. Its advantages include ease of use, speed and familiarity for radiographers and clinicians.
Co-registered high frequency PA/US was used in the assessment of mesenchymal stem cells (MSCs) induced neovascularization/angiogenesis in vivo. In the first study, combined PA and US
imaging, operated with 40 MHz frequency linear-array transducer probe was used in the assessment of topical human MSCs seeded in Excellagen™ scaffold based treatment to a dermal wound on the rabbit ear skin. In the second study, combined PA and US
imaging, operated with 21 MHz frequency linear-array transducer probe and micro computed…
Advisors/Committee Members: Leahy, Martin (advisor).
Subjects/Keywords: Physics;
Optical coherence tomography;
Optoacoustic imaging;
Microcirculation imaging;
Optical imaging;
Tissue optics
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APA ·
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Manager
APA (6th Edition):
Zafar, H. (2016). Development and applications of optical imaging techniques for microcirculation and cardiovascular imaging
. (Thesis). National University of Ireland – Galway. Retrieved from http://hdl.handle.net/10379/5962
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Zafar, Haroon. “Development and applications of optical imaging techniques for microcirculation and cardiovascular imaging
.” 2016. Thesis, National University of Ireland – Galway. Accessed January 19, 2021.
http://hdl.handle.net/10379/5962.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Zafar, Haroon. “Development and applications of optical imaging techniques for microcirculation and cardiovascular imaging
.” 2016. Web. 19 Jan 2021.
Vancouver:
Zafar H. Development and applications of optical imaging techniques for microcirculation and cardiovascular imaging
. [Internet] [Thesis]. National University of Ireland – Galway; 2016. [cited 2021 Jan 19].
Available from: http://hdl.handle.net/10379/5962.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Zafar H. Development and applications of optical imaging techniques for microcirculation and cardiovascular imaging
. [Thesis]. National University of Ireland – Galway; 2016. Available from: http://hdl.handle.net/10379/5962
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Washington
18.
Chu, Zhongdi.
Quantitative Applications of Optical Coherence Tomography Angiography in Ophthalmology.
Degree: PhD, 2019, University of Washington
URL: http://hdl.handle.net/1773/44039
► Optical coherence tomography (OCT) angiography (OCTA) is a recently developed non-invasive functional imaging technique that have been widely utilized in ophthalmology. OCTA is capable of…
(more)
▼ Optical
coherence tomography (OCT) angiography (OCTA) is a recently developed non-invasive functional
imaging technique that have been widely utilized in ophthalmology. OCTA is capable of providing three dimensional detailed information of ocular vasculature and has great potentials for vascular quantification. In this thesis, OCTA’s capacity in
imaging microvasculature in great detail was demonstrated in human eyes, techniques to improve image quality and contrast were proposed and validated. With clinically available OCTA systems’ data, quantitative analysis tools for both retinal choroidal microvasculature were developed and tested on diseased subjects. The reliability of proposed quantitative algorithms was tested with intra-visit scans and the robustness was tested with data from a wide range of disease diagnoses. Overall, this dissertation presents a set of tools that can describe the integrity of human ocular microvasculature reliably and objectively.
Advisors/Committee Members: Wang, Ruikang K (advisor).
Subjects/Keywords: Image Processing; Ophthalmology; Optical Coherence Tomography; Optical Coherence Tomography Angiography; Bioengineering; Medical imaging; Bioengineering
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APA ·
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MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Chu, Z. (2019). Quantitative Applications of Optical Coherence Tomography Angiography in Ophthalmology. (Doctoral Dissertation). University of Washington. Retrieved from http://hdl.handle.net/1773/44039
Chicago Manual of Style (16th Edition):
Chu, Zhongdi. “Quantitative Applications of Optical Coherence Tomography Angiography in Ophthalmology.” 2019. Doctoral Dissertation, University of Washington. Accessed January 19, 2021.
http://hdl.handle.net/1773/44039.
MLA Handbook (7th Edition):
Chu, Zhongdi. “Quantitative Applications of Optical Coherence Tomography Angiography in Ophthalmology.” 2019. Web. 19 Jan 2021.
Vancouver:
Chu Z. Quantitative Applications of Optical Coherence Tomography Angiography in Ophthalmology. [Internet] [Doctoral dissertation]. University of Washington; 2019. [cited 2021 Jan 19].
Available from: http://hdl.handle.net/1773/44039.
Council of Science Editors:
Chu Z. Quantitative Applications of Optical Coherence Tomography Angiography in Ophthalmology. [Doctoral Dissertation]. University of Washington; 2019. Available from: http://hdl.handle.net/1773/44039
19.
Dsouza, Roshan Isdore.
Towards low cost multiple reference optical coherence tomography for in vivo and NDT applications
.
Degree: 2016, National University of Ireland – Galway
URL: http://hdl.handle.net/10379/5481
► Developing a cost-effective, compact, and easy-to-use optical coherence tomography (OCT) platform based on smartphones for personal care and point-of-care (POC) diagnostics can enable rapid and…
(more)
▼ Developing a cost-effective, compact, and easy-to-use optical
coherence tomography
(OCT) platform based on smartphones for personal care and point-of-care (POC) diagnostics
can enable rapid and accurate diagnosis with reduced cost and time. However,
current embodiments of commercially available OCT systems are bulky, expensive
and only suitable for stationary use in clinical applications. This thesis describes
the design and implementation of a novel, low-cost OCT technology called multiple
reference OCT (MR-OCT) for next-generation smartphone based personal care and
POC applications.
MR-OCT is an extension of time-domain OCT (TD-OCT), with the addition of a partial
mirror (PM) placed a small distance in front of the reference mirror (RM). The
combination of the PM and the oscillating RM generates a composite reference signal
based on multiple reflections between the partial mirror and the oscillating reference
mirror to provide reference light corresponding to increasing depths. This arrangement
enables MR-OCT to be implemented at low cost and as a miniature device. The
results demonstrated in this thesis show the feasibility of MR-OCT and demonstrate
a wide range of industrial, medical and consumer level applications. The first generation
MR-OCT setup utilised a piezoelectric transducer (PZT) as a depth scanning
mechanism. Although, a PZT transducer provides excellent linearity, the cost and
size of the PZT controller is a limiting factor for producing a low-cost and compact
MR-OCT system. Furthermore, PZT devices require a high driving voltage, which
makes them less suitable for consumer applications. For this reason, the second generation
MR-OCT setup utilised a voice coil motor (VCM) which was extracted from a
CD/DVD-ROM. The dimensions of the VCM are approximately 15 mm × 15 mm and
can be purchased for about 0.50 Euro. Experimental implementation of the MR-OCT
system was based on a free-space Michelson interferometer. The VCM was driven at
a frequency of 600 Hz and utilised forward and backward scans to obtain a total scan
rate of 1200 A-lines per seconds. The system achieved an axial resolution of about 13 µm and a transverse resolution of about 27 µm (in air). Of the multiple reflections generated
by the MR-OCT arrangement, up to 12 orders of reflections were investigated.
The usefulness of orders higher than 12 was limited due to the transmission ratio of
the PM. The measured sensitivity for the first and ninth orders were 89 dB and 78 dB with a phase stability of Δφ1 = 0.21 ± 0.14 rad and Δφ9 = 1.15 ± 0.7 rad.
The capabilities of the system were demonstrated with various biological and nondestructive
testing (NDT) samples. Fingerprint scanning on human subjects reveals
both surface and sub-surface structure of the fingertip. This enables improved authentication
by verifying compatibility between the conventional surface fingerprint
and the sub-surface fingerprint and by also detecting liveness through a phase-sensitive
method. NDT applications include the evaluation…
Advisors/Committee Members: Leahy, Martin J (advisor).
Subjects/Keywords: Optical coherence tomography;
Multiple reference optical coherence tomography;
Low cost OCT;
Interferometric imaging;
Physics;
Biophotonics;
Tissue Optics and Microcirculation Imaging Group
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APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Dsouza, R. I. (2016). Towards low cost multiple reference optical coherence tomography for in vivo and NDT applications
. (Thesis). National University of Ireland – Galway. Retrieved from http://hdl.handle.net/10379/5481
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Dsouza, Roshan Isdore. “Towards low cost multiple reference optical coherence tomography for in vivo and NDT applications
.” 2016. Thesis, National University of Ireland – Galway. Accessed January 19, 2021.
http://hdl.handle.net/10379/5481.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Dsouza, Roshan Isdore. “Towards low cost multiple reference optical coherence tomography for in vivo and NDT applications
.” 2016. Web. 19 Jan 2021.
Vancouver:
Dsouza RI. Towards low cost multiple reference optical coherence tomography for in vivo and NDT applications
. [Internet] [Thesis]. National University of Ireland – Galway; 2016. [cited 2021 Jan 19].
Available from: http://hdl.handle.net/10379/5481.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Dsouza RI. Towards low cost multiple reference optical coherence tomography for in vivo and NDT applications
. [Thesis]. National University of Ireland – Galway; 2016. Available from: http://hdl.handle.net/10379/5481
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Vanderbilt University
20.
O'Grady, Kristin Poole.
Development of Optical Imaging Methods for Evaluating the Vascular Response to Hind Limb Ischemia.
Degree: PhD, Biomedical Engineering, 2015, Vanderbilt University
URL: http://hdl.handle.net/1803/14695
► Peripheral arterial disease (PAD) affects millions of individuals and increases the risk of myocardial infarction, stroke, and mortality. Compared to the general population, diabetic patients…
(more)
▼ Peripheral arterial disease (PAD) affects millions of individuals and increases the risk of myocardial infarction, stroke, and mortality. Compared to the general population, diabetic patients have a four times greater risk of developing PAD, worse lower-extremity function, and a greater risk of amputation. Gaining a better understanding of the mechanisms through which diabetes impairs arteriogenesis in PAD and developing novel treatments that are less invasive and more effective than the current standard of care are areas of significant focus within basic and clinical cardiovascular research. The mouse hind limb ischemia (HLI) model is a widely used system for studying the mechanisms of arteriogenesis and for testing new PAD therapies, but there is a lack of techniques for acquiring physiologically-relevant, quantitative data intravitally in this model. In this work, non-invasive, quantitative hyperspectral
imaging of hemoglobin saturation and optical
coherence tomography
imaging of vessel structure and function were developed and validated for the HLI model. This optical
imaging platform was applied to study the effects of hyperglycemia on recovery from ischemia and identify a relevant preclinical model that incorporates a cardiovascular risk factor associated with PAD in humans. Additionally, the optical
imaging techniques were applied in combination with traditional methods to evaluate reactive oxygen species-responsive, “on demand” local release of antioxidant and anti-inflammatory therapies that target molecular drivers of the impaired vascular response to ischemia in diabetic animals. Overall, this work facilitates the use of more complex and more physiologically relevant mouse models of PAD such as diabetic and aged animals through a reduction in both the number of cohorts required and the time required for acquisition of comprehensive longitudinal data. This advance in preclinical methodologies is anticipated to accelerate the development of improved therapeutic clinical treatments for PAD.
Advisors/Committee Members: Jeffrey Davidson (committee member), David Harrison (committee member), Bruce Damon (committee member), Craig Duvall (Committee Chair), Melissa Skala (Committee Chair).
Subjects/Keywords: optical coherence tomography; ischemia; optical imaging; antioxidant therapy; diabetes; oxidative stress; hyperspectral imaging
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APA (6th Edition):
O'Grady, K. P. (2015). Development of Optical Imaging Methods for Evaluating the Vascular Response to Hind Limb Ischemia. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/14695
Chicago Manual of Style (16th Edition):
O'Grady, Kristin Poole. “Development of Optical Imaging Methods for Evaluating the Vascular Response to Hind Limb Ischemia.” 2015. Doctoral Dissertation, Vanderbilt University. Accessed January 19, 2021.
http://hdl.handle.net/1803/14695.
MLA Handbook (7th Edition):
O'Grady, Kristin Poole. “Development of Optical Imaging Methods for Evaluating the Vascular Response to Hind Limb Ischemia.” 2015. Web. 19 Jan 2021.
Vancouver:
O'Grady KP. Development of Optical Imaging Methods for Evaluating the Vascular Response to Hind Limb Ischemia. [Internet] [Doctoral dissertation]. Vanderbilt University; 2015. [cited 2021 Jan 19].
Available from: http://hdl.handle.net/1803/14695.
Council of Science Editors:
O'Grady KP. Development of Optical Imaging Methods for Evaluating the Vascular Response to Hind Limb Ischemia. [Doctoral Dissertation]. Vanderbilt University; 2015. Available from: http://hdl.handle.net/1803/14695
Texas A&M University
21.
Shrestha, Sebina.
Development of Dual-Modality Optical Imaging Systems Consisting of Optical Coherence Tomography and Fluorescence Lifetime Imaging Microscopy.
Degree: PhD, Biomedical Engineering, 2015, Texas A&M University
URL: http://hdl.handle.net/1969.1/155617
► Both morphological and biochemical changes occur in a diseased tissue. As a result, tissue optical response changes with the progression of disease. A single optical…
(more)
▼ Both morphological and biochemical changes occur in a diseased tissue. As a result, tissue optical response changes with the progression of disease. A single optical
imaging modality can assess either morphological or biochemical changes. In order to investigate the development of a disease in detail, both of these characteristics need to be probed simultaneously. Therefore, researchers have been interested in combining different
imaging modalities that can provide complementary, morphological and biochemical images. This dissertation focuses on the development of dual-modality systems that incorporate Optical
coherence Tomography (OCT) and Fluorescence Lifetime
Imaging Microscopy (FLIM) for simultaneous characterization of tissue morphology and its biochemistry.
In the first phase of the research, we combined spectral-domain OCT with FLIM that is designed for endogenous emission acquisition. The operating wavelength for OCT and FLIM were 830nm and 355nm, respectively. The maximum field of view (FOV) was 4mmx4mm. The combined system was used to image hamster cheek pouch model for oral cancer in vivo and postmortem human coronary arteries with atherosclerotic plaques ex vivo. Their morphological and endogenous emission images correlation was studied. The evaluation was equivalent to their histopathological analysis.
In the second phase of this research, we built a bench-top prototype that comprised of swept source OCT (SSOCT) and a FLIM system with the capability to characterize endogenous and exogenous emissions simultaneously. The swept laser had a sweep rate of 50 kHz and the center wavelength was at 1310nm. FLIM utilized lasers with wavelengths 355nm and 532nm to excite endogenous and exogenous fluorophores, respectively. The maximum FOV was 16mmx16mm. With this system, OCT-FLIM images of a Watanabe rabbit aorta, which was non-specifically tagged with Alexa Fluor 532, were acquired ex-vivo. The results appraised the ability of the system to simultaneously probe the sample’s structure, its endogenous emission and the exogenous fluorescence of the dye tagged to it. We hypothesize that the OCT-FLIM
imaging tool adds a potential to study the activities of important non-fluorescing molecules in an artery while relating the analysis to its morphology and biochemistry.
Advisors/Committee Members: Applegate, Brian E (advisor), Jo, Javier A (committee member), Maitland, Kristen C (committee member), Eknoyan, Ohannes (committee member).
Subjects/Keywords: Optical Coherence Tomography; Fluorescence Lifetime Imaging Microscopy; Atherosclerosis; Oral Cancer; dual-modality optical imaging system
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APA ·
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MLA ·
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CSE |
Export
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Manager
APA (6th Edition):
Shrestha, S. (2015). Development of Dual-Modality Optical Imaging Systems Consisting of Optical Coherence Tomography and Fluorescence Lifetime Imaging Microscopy. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/155617
Chicago Manual of Style (16th Edition):
Shrestha, Sebina. “Development of Dual-Modality Optical Imaging Systems Consisting of Optical Coherence Tomography and Fluorescence Lifetime Imaging Microscopy.” 2015. Doctoral Dissertation, Texas A&M University. Accessed January 19, 2021.
http://hdl.handle.net/1969.1/155617.
MLA Handbook (7th Edition):
Shrestha, Sebina. “Development of Dual-Modality Optical Imaging Systems Consisting of Optical Coherence Tomography and Fluorescence Lifetime Imaging Microscopy.” 2015. Web. 19 Jan 2021.
Vancouver:
Shrestha S. Development of Dual-Modality Optical Imaging Systems Consisting of Optical Coherence Tomography and Fluorescence Lifetime Imaging Microscopy. [Internet] [Doctoral dissertation]. Texas A&M University; 2015. [cited 2021 Jan 19].
Available from: http://hdl.handle.net/1969.1/155617.
Council of Science Editors:
Shrestha S. Development of Dual-Modality Optical Imaging Systems Consisting of Optical Coherence Tomography and Fluorescence Lifetime Imaging Microscopy. [Doctoral Dissertation]. Texas A&M University; 2015. Available from: http://hdl.handle.net/1969.1/155617
Texas A&M University
22.
Carbajal, Esteban Franco.
Integrating OCT into Surgical Systems and Monitoring Vibrations.
Degree: MS, Biomedical Engineering, 2016, Texas A&M University
URL: http://hdl.handle.net/1969.1/187397
► Imaging of the hearing structures can yield information regarding their function as well as insight into the abnormalities and adverse conditions that affect them. Improvements…
(more)
▼ Imaging of the hearing structures can yield information regarding their function as well as insight into the abnormalities and adverse conditions that affect them. Improvements in the acquisition techniques and the quality of
imaging systems can contribute to the understanding and treatment of these conditions. Optical
coherence tomography (OCT)
imaging technology has evolved to the point where systems can deliver 2D cross-sectional images, 3D structural volumes, and functional information regarding the motion of the sample. The information is valuable, but while research systems continue to evolve and become more advanced there is a disconnect between the researcher and the clinician. Translation of research based
imaging systems into the clinical field is an important step in future development and adaptation. This thesis is focused on the development of a packaged optical
coherence tomography system and the design of a phase-stable surgical microscope OCT system that can easily be introduced into the clinical field.
Advisors/Committee Members: Applegate, Brian E (advisor), Jo, Javier (committee member), Lenox, Mark (committee member).
Subjects/Keywords: Optical Coherence Tomography; OCT; Imaging; SSOCT; Swept-Source; Phase; Imaging; 3D Printing
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APA ·
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to Zotero / EndNote / Reference
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APA (6th Edition):
Carbajal, E. F. (2016). Integrating OCT into Surgical Systems and Monitoring Vibrations. (Masters Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/187397
Chicago Manual of Style (16th Edition):
Carbajal, Esteban Franco. “Integrating OCT into Surgical Systems and Monitoring Vibrations.” 2016. Masters Thesis, Texas A&M University. Accessed January 19, 2021.
http://hdl.handle.net/1969.1/187397.
MLA Handbook (7th Edition):
Carbajal, Esteban Franco. “Integrating OCT into Surgical Systems and Monitoring Vibrations.” 2016. Web. 19 Jan 2021.
Vancouver:
Carbajal EF. Integrating OCT into Surgical Systems and Monitoring Vibrations. [Internet] [Masters thesis]. Texas A&M University; 2016. [cited 2021 Jan 19].
Available from: http://hdl.handle.net/1969.1/187397.
Council of Science Editors:
Carbajal EF. Integrating OCT into Surgical Systems and Monitoring Vibrations. [Masters Thesis]. Texas A&M University; 2016. Available from: http://hdl.handle.net/1969.1/187397
Columbia University
23.
Yao, Xinwen.
Ultrahigh resolution spectral domain optical coherence tomography and its functional extension for human myocardium and breast tissue imaging.
Degree: 2018, Columbia University
URL: https://doi.org/10.7916/D8HD92J7
► Over the past 25 years of development and innovation, optical coherence tomography (OCT) has successfully fills the gap between the ex vivo high-resolution optical microscopy…
(more)
▼ Over the past 25 years of development and innovation, optical coherence tomography (OCT) has successfully fills the gap between the ex vivo high-resolution optical microscopy technologies and in vivo low-resolution medical imaging modalities, including computed tomography (CT), magnetic resonance imaging (MRI), ultrasound (US). Ultrahigh resolution (UHR) OCT categorizes OCT systems with an axial resolution below 3 µm in tissue. With the improved resolution, UHR OCT may impart the knowledge of detailed structures of the tissues that are almost close to what histology may provide. This is how UHR OCT can act as a bridge between radiology and histology. This thesis will present an ultrahigh-resolution (UHR) spectral domain (SD) OCT system that features both high axial resolution and long imaging range, and will demonstrate its applications in human myocardium and breast tissue imaging. The UHR OCT system accommodates a supercontinuum light source, and a home-built spectrometer designed to achieve optimized imaging performance. Specifically, the spectrometer features a customized focusing lenses that are comprised of off-the-shelf optics and a 2k-pixel camera to minimize the cost of the instrument. The system manifests an axial resolution of 2.72 µm and a lateral resolution of 5.52 µm, with a large imaging range of 1.78 mm. The sensitivity of the system is 93 dB with a 6-dB sensitivity fall-off range of 0.89 mm.
For human myocardium, currently there is no high-resolution non-destructive real-time imaging modality available for biopsy guidance. As a real-time and non-destructive imaging tool, UHR OCT offers additional benefits compared with standard OCT, which are illustrated by successful delineation of micro-structures such as thin elastic fibers and Purkinje fibers in the endomyocardial side. These structures are otherwise not visible within standard-resolution OCT images. Moreover, by adding the cross-polarization (CP) functionality to the UHR SD system, different types of myocardial tissue can be better delineated through the CP contrast. The functional information provided by CP-OCT may also facilitate automatic tissue classification by using A-line signals.
For breast tissue imaging, we show qualitatively and quantitatively that UHR OCT images may enable better visualization of detailed features in different types of breast tissue, including healthy and cancerous ones. UHR OCT images of new breast cancer types such as phyllodes tumor, necrotic tumor and fibrotic focus carcinoma are provided for future references. Features developed from UHR OCT images enable a better yield from relevance vector machine (RVM) based stochastic classification model, compared with that from standard resolution OCT images. UHR OCT shows a great promise for automated classification of different tissue types in human breast tissue based off on UHR OCT images.
Lastly, we present our endeavor to miniaturize the UHR OCT system on chip. We explore a chip-based optical frequency comb source that may enable UHR OCT at longer…
Subjects/Keywords: Electrical engineering; Biomedical engineering; Optical coherence tomography; Tissues – Imaging; Imaging systems in medicine
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APA (6th Edition):
Yao, X. (2018). Ultrahigh resolution spectral domain optical coherence tomography and its functional extension for human myocardium and breast tissue imaging. (Doctoral Dissertation). Columbia University. Retrieved from https://doi.org/10.7916/D8HD92J7
Chicago Manual of Style (16th Edition):
Yao, Xinwen. “Ultrahigh resolution spectral domain optical coherence tomography and its functional extension for human myocardium and breast tissue imaging.” 2018. Doctoral Dissertation, Columbia University. Accessed January 19, 2021.
https://doi.org/10.7916/D8HD92J7.
MLA Handbook (7th Edition):
Yao, Xinwen. “Ultrahigh resolution spectral domain optical coherence tomography and its functional extension for human myocardium and breast tissue imaging.” 2018. Web. 19 Jan 2021.
Vancouver:
Yao X. Ultrahigh resolution spectral domain optical coherence tomography and its functional extension for human myocardium and breast tissue imaging. [Internet] [Doctoral dissertation]. Columbia University; 2018. [cited 2021 Jan 19].
Available from: https://doi.org/10.7916/D8HD92J7.
Council of Science Editors:
Yao X. Ultrahigh resolution spectral domain optical coherence tomography and its functional extension for human myocardium and breast tissue imaging. [Doctoral Dissertation]. Columbia University; 2018. Available from: https://doi.org/10.7916/D8HD92J7
University of Missouri – Columbia
24.
Fan, Chuanmao.
True depth resolved polarization sensitive optical coherence tomography.
Degree: 2012, University of Missouri – Columbia
URL: https://doi.org/10.32469/10355/41917
► Polarization sensitive optical coherence tomography (PSOCT) can image sample polarization properties including retardance, diattenuance, and optical axis and has potential applications in many biomedical fields.…
(more)
▼ Polarization sensitive optical
coherence tomography (PSOCT) can image sample polarization properties including retardance, diattenuance, and optical axis and has potential applications in many biomedical fields. However, due to the round-trip nature of OCT measurements, conventional PSOCT can only measure the cumulative optical properties that are affected by optical properties from sample surface to the
imaging depth. Such cumulative image results cannot be directly used for optical diagnosis. In this research, novel PSOCT systems and image processing algorithms were developed for mapping depth-resolved local polarization properties from conventional cumulative polarization measurements. The new algorithms were tested in both ex vivo and in vivo biological tissues. Using local optical axis, fiber bundles in bovine heart muscle were successfully visualized in depth-resolved 3D images.
Advisors/Committee Members: Yao, Gang, Ph. D. (advisor).
Subjects/Keywords: Optical coherence tomography; Polarization sensitive device; Optical imaging; Biomedical optics; Medicine and biological imaging
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APA (6th Edition):
Fan, C. (2012). True depth resolved polarization sensitive optical coherence tomography. (Thesis). University of Missouri – Columbia. Retrieved from https://doi.org/10.32469/10355/41917
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Fan, Chuanmao. “True depth resolved polarization sensitive optical coherence tomography.” 2012. Thesis, University of Missouri – Columbia. Accessed January 19, 2021.
https://doi.org/10.32469/10355/41917.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Fan, Chuanmao. “True depth resolved polarization sensitive optical coherence tomography.” 2012. Web. 19 Jan 2021.
Vancouver:
Fan C. True depth resolved polarization sensitive optical coherence tomography. [Internet] [Thesis]. University of Missouri – Columbia; 2012. [cited 2021 Jan 19].
Available from: https://doi.org/10.32469/10355/41917.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Fan C. True depth resolved polarization sensitive optical coherence tomography. [Thesis]. University of Missouri – Columbia; 2012. Available from: https://doi.org/10.32469/10355/41917
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Arizona
25.
Sassu, Matthew George.
Software Implementation of a Combined Fluorescence and Swept Source Optical Coherence Tomography Imaging System
.
Degree: 2018, University of Arizona
URL: http://hdl.handle.net/10150/631417
► This paper serves as a detailed overview of the software developed for the Falloposcope endoscope being developed by the Jennifer Barton Optics Tissue Laboratory. The…
(more)
▼ This paper serves as a detailed overview of the software developed for the Falloposcope endoscope being developed by the Jennifer Barton Optics Tissue Laboratory. The Falloposcope is designed for a screening procedure for early detection of ovarian cancer in the fallopian tubes. The software controls a charge-coupled device (CCD) camera to perform reflectance and fluorescence
imaging, which serves to navigate the endoscope to the fallopian tubes and surveil suspicious tissue regions. It also controls a swept source optical
coherence tomography (SS-OCT)
imaging system to provide high resolution, cross-sectional tomographic images of these tissue regions. CCD
imaging is performed using a Princeton Instruments Pixis 1024B Digital CCD camera system. OCT
imaging is performed using a Santec HSL-2100 swept source infrared laser and BPD-200-ST photodetector, as well as an AlazarTech ATS-9462 data acquisition board. Data from these instruments is displayed on a graphic user interface written in C++/CLI. This paper details how each of these
imaging systems functions, from hardware control through data processing and visualization, as well as how more challenging programming tasks were completed. The core functionality of each system is complete, but there remain some parameters of the OCT data display which remain to be finalized. The available options, as well as the standard practices within the medical industry around OCT
imaging, are discussed.
Advisors/Committee Members: Barton, Jennifer Kehlet (advisor), Utzinger, Urs (committeemember), Koshel, John (committeemember).
Subjects/Keywords: AlazarTech;
CCD Imaging;
C++/CLI;
Fluorescence Imaging;
SS-OCT;
Swept Source Optical Coherence Tomography
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APA (6th Edition):
Sassu, M. G. (2018). Software Implementation of a Combined Fluorescence and Swept Source Optical Coherence Tomography Imaging System
. (Masters Thesis). University of Arizona. Retrieved from http://hdl.handle.net/10150/631417
Chicago Manual of Style (16th Edition):
Sassu, Matthew George. “Software Implementation of a Combined Fluorescence and Swept Source Optical Coherence Tomography Imaging System
.” 2018. Masters Thesis, University of Arizona. Accessed January 19, 2021.
http://hdl.handle.net/10150/631417.
MLA Handbook (7th Edition):
Sassu, Matthew George. “Software Implementation of a Combined Fluorescence and Swept Source Optical Coherence Tomography Imaging System
.” 2018. Web. 19 Jan 2021.
Vancouver:
Sassu MG. Software Implementation of a Combined Fluorescence and Swept Source Optical Coherence Tomography Imaging System
. [Internet] [Masters thesis]. University of Arizona; 2018. [cited 2021 Jan 19].
Available from: http://hdl.handle.net/10150/631417.
Council of Science Editors:
Sassu MG. Software Implementation of a Combined Fluorescence and Swept Source Optical Coherence Tomography Imaging System
. [Masters Thesis]. University of Arizona; 2018. Available from: http://hdl.handle.net/10150/631417
Lehigh University
26.
Huang, Yongyang.
Development of High-speed Optical Coherence Tomography for Time-lapse Non-destructive Characterization of Samples.
Degree: PhD, Electrical Engineering, 2019, Lehigh University
URL: https://preserve.lehigh.edu/etd/5564
Optical coherence tomography (OCT) is an established optical imaging modality which can obtain label-free, non-destructive 3D images of samples with micron-scale resolution and millimeter penetration. OCT has been widely adopted for biomedical researches
Advisors/Committee Members: Zhou, Chao.Subjects/Keywords: High-throughput Imaging; Non-destructive Evaluation; Optical Coherence Tomography; Optical Coherence Tomography Angiography; Space-division Multiplexing Optical Coherence Tomography; Time-lapse Imaging; Electrical and Computer Engineering
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APA ·
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MLA ·
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to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Huang, Y. (2019). Development of High-speed Optical Coherence Tomography for Time-lapse Non-destructive Characterization of Samples. (Doctoral Dissertation). Lehigh University. Retrieved from https://preserve.lehigh.edu/etd/5564
Chicago Manual of Style (16th Edition):
Huang, Yongyang. “Development of High-speed Optical Coherence Tomography for Time-lapse Non-destructive Characterization of Samples.” 2019. Doctoral Dissertation, Lehigh University. Accessed January 19, 2021.
https://preserve.lehigh.edu/etd/5564.
MLA Handbook (7th Edition):
Huang, Yongyang. “Development of High-speed Optical Coherence Tomography for Time-lapse Non-destructive Characterization of Samples.” 2019. Web. 19 Jan 2021.
Vancouver:
Huang Y. Development of High-speed Optical Coherence Tomography for Time-lapse Non-destructive Characterization of Samples. [Internet] [Doctoral dissertation]. Lehigh University; 2019. [cited 2021 Jan 19].
Available from: https://preserve.lehigh.edu/etd/5564.
Council of Science Editors:
Huang Y. Development of High-speed Optical Coherence Tomography for Time-lapse Non-destructive Characterization of Samples. [Doctoral Dissertation]. Lehigh University; 2019. Available from: https://preserve.lehigh.edu/etd/5564
Universiteit Utrecht
27.
Norel, J. van.
Macular edema in uveitis with emphasis on ocular sarcoidosis.
Degree: 2015, Universiteit Utrecht
URL: http://dspace.library.uu.nl:8080/handle/1874/312605
► This thesis investigates the accumulation of fluid in the yellow spot (macular edema) in ocular inflammation (uveitis). Macular edema may result in definitive loss of…
(more)
▼ This thesis investigates the accumulation of fluid in the yellow spot (macular edema) in ocular inflammation (uveitis). Macular edema may result in definitive loss of vision.Two methods of
imaging of macular edema are fluorescein angiography (FA) and optical
coherence tomography (OCT). The first method provides physiological information, the latter anatomical information. Comparison of FA and OCT images revealed that nearly half of the eyes had discrepant findings. In 30% of the eyes a mild fluorescein leakage was found but no retinal thickening or retinal cysts were seen on OCT. We speculate that in a thin retina a retinal thickening is not easily recognized. OCT revealed ME in 15% of the eyes with no leakage on FA. This discrepancy was common in inactive uveitis and also occurred more often in young patients with an intermediate uveitis. Possible explanations are that this type of edema is intracellularly located or that this edema represents the remains of accumulated fluid after the uveitis subsided and the active leakage had stopped. We emphasize the importance of performing both investigations.
We investigated the significance of subretinal fluid in macular edema in uveitis. We conclude that SRD develops in the early stages of ME and uveitis but responds well to medical treatment.
We propose a treatment algorithm where we suggest starting with periocular steroid injections (especially in those with unilateral ME) and if this is insufficient or in bilateral cases, immunomodulatory drugs are recommended. When inflammation is under control, but ME persists, the pump function of the retinal pigment epithelium can be stimulated by oral acetazolamide or somatostatin analogues.
We investigated peripheral multifocal choroiditis (PMC), which is a chronic bilateral uveitis with vitritis and multiple punched out lesions in the retinal periphery in the absence of central chorioretinal lesions. A high association with sarcoidosis was found. A high cumulative incidence of ME of 81% was found and a prevalence of glaucoma of 35%, which is higher than in the general uveitis population. We report on a new characteristic of PMC, specifically papillitis, which was experienced by 95% of all PMC patients, resulting in 25% of the patients with optic atrophy. Despite many medical and surgical interventions, about 70% of the eyes had a visual acuity of at least 0.5 at ten years follow-up.
The diagnosis of ocular sarcoidosis is difficult to prove and it frequently occurs that a uveitis is suspected to be related to sarcoidosis, but cannot be proven. Soluble interleukin-2 receptor (sIL-2R) and angiotensin-converting enzyme (ACE) are two markers that are used for the follow-up of systemic sarcoidosis patients but which have a low diagnostic sensitivity and specificity in the setting of uveitis. Although elevated intraocular levels of ACE or sIL-2R were found in sarcoidosis patients compared to non-inflammatory controls, a large overlap existed between the sarcoidosis-associated uveitis and the controls with infectious uveitis. We…
Advisors/Committee Members: Rothova, A..
Subjects/Keywords: macular edema; uveitis; ocular sarcoidosis; imaging; fluorescein angiography; optical coherence tomography
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APA ·
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APA (6th Edition):
Norel, J. v. (2015). Macular edema in uveitis with emphasis on ocular sarcoidosis. (Doctoral Dissertation). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/312605
Chicago Manual of Style (16th Edition):
Norel, J van. “Macular edema in uveitis with emphasis on ocular sarcoidosis.” 2015. Doctoral Dissertation, Universiteit Utrecht. Accessed January 19, 2021.
http://dspace.library.uu.nl:8080/handle/1874/312605.
MLA Handbook (7th Edition):
Norel, J van. “Macular edema in uveitis with emphasis on ocular sarcoidosis.” 2015. Web. 19 Jan 2021.
Vancouver:
Norel Jv. Macular edema in uveitis with emphasis on ocular sarcoidosis. [Internet] [Doctoral dissertation]. Universiteit Utrecht; 2015. [cited 2021 Jan 19].
Available from: http://dspace.library.uu.nl:8080/handle/1874/312605.
Council of Science Editors:
Norel Jv. Macular edema in uveitis with emphasis on ocular sarcoidosis. [Doctoral Dissertation]. Universiteit Utrecht; 2015. Available from: http://dspace.library.uu.nl:8080/handle/1874/312605
Ryerson University
28.
Wan Hei Luk, Timothy.
Decorrelation Time Analysis Using Dynamic Light Scattering with Optical Coherence Tomography in an in vivo Mouse Tumour Model.
Degree: 2013, Ryerson University
URL: https://digital.library.ryerson.ca/islandora/object/RULA%3A1531
► Optical coherence tomography (OCT) is an imaging modality that uses near infrared light interferometry for non-invasive, near-histological resolution imaging at the micron level. Concepts from…
(more)
▼ Optical coherence tomography (OCT) is an imaging modality that uses near infrared light interferometry for non-invasive, near-histological resolution imaging at the micron level. Concepts from dynamic light scattering (DLS) can be adapted to OCT to detect and measure the motions in the target tissue. Tissue dynamics can be observed by measuring the speckle decorrelation time (DT) of the tissue. DT analysis was performed in a preclinical study to demonstrate the repeatability and feasibility of using DLS-OCT to observe mouse tumours undergoing cisplatin treatment over a 48-hour period. Differences in the average DT data were observed for control and cisplatin-injected mice. Image segmentation based on DT values was also performed to subtract the DT contributions of pixels at blood vessel locations, resulting in the improvement of average DT calculations of the tumour tissue. The results presented are a preliminary step to analyzing and monitoring tumour growth and treatment response in vivo.
Subjects/Keywords: Optical coherence tomography; Tumors; Light – Scattering; Imaging systems in medicine
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APA (6th Edition):
Wan Hei Luk, T. (2013). Decorrelation Time Analysis Using Dynamic Light Scattering with Optical Coherence Tomography in an in vivo Mouse Tumour Model. (Thesis). Ryerson University. Retrieved from https://digital.library.ryerson.ca/islandora/object/RULA%3A1531
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Wan Hei Luk, Timothy. “Decorrelation Time Analysis Using Dynamic Light Scattering with Optical Coherence Tomography in an in vivo Mouse Tumour Model.” 2013. Thesis, Ryerson University. Accessed January 19, 2021.
https://digital.library.ryerson.ca/islandora/object/RULA%3A1531.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Wan Hei Luk, Timothy. “Decorrelation Time Analysis Using Dynamic Light Scattering with Optical Coherence Tomography in an in vivo Mouse Tumour Model.” 2013. Web. 19 Jan 2021.
Vancouver:
Wan Hei Luk T. Decorrelation Time Analysis Using Dynamic Light Scattering with Optical Coherence Tomography in an in vivo Mouse Tumour Model. [Internet] [Thesis]. Ryerson University; 2013. [cited 2021 Jan 19].
Available from: https://digital.library.ryerson.ca/islandora/object/RULA%3A1531.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Wan Hei Luk T. Decorrelation Time Analysis Using Dynamic Light Scattering with Optical Coherence Tomography in an in vivo Mouse Tumour Model. [Thesis]. Ryerson University; 2013. Available from: https://digital.library.ryerson.ca/islandora/object/RULA%3A1531
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Ryerson University
29.
Vuong, Barry.
Development of an Intravascular Doppler Optical Coherence Tomography Imaging Technique for
Neurovascular Applications.
Degree: 2014, Ryerson University
URL: https://digital.library.ryerson.ca/islandora/object/RULA%3A3799
► The rupture of an intracranial aneurysm can cause spontaneous subarachnoid hemorrhage and result in sudden death. A large portion of intracranial aneurysms occurs near the…
(more)
▼ The rupture of an intracranial aneurysm can cause spontaneous subarachnoid hemorrhage and result in sudden death. A large portion of intracranial aneurysms occurs near the center of the head, at the skull base, which poses significant technical challenge to neurosurgeons due to limited accessibility. The utilization of angiography is prominent during the treatment of intracranial aneurysms. However, malapposition of stent or incomplete packing of the intracranial aneurysm can be difficult to assess with angiography, and could lead to severe postoperative complications. As a result, angiography may not be sufficient in determining the risk of rupture as the compensatory mechanisms are known to occur at the microstructural level due to the local hemodynamics in the arterial lumen, as well as in evaluating the intraoperative treatment.
In this work, we describe a method for assessing intracranial aneurysm through the evaluation of blood flow within the lumen and morphological structures of the arterial wall with optical
coherence tomography (OCT). Sterile intravascular fiber-optic catheters can be introduced in the artery to detect blood flow. Prior to this work, limited investigations of catheter based Doppler OCT (DOCT) were reported. A novel signal processing technique was developed to further reduce the effect of Doppler noise within a catheter based DOCT system. This technique consisted of splitting the interferogram of an OCT signal prior to estimating the Doppler shift. This split spectrum DOCT (ssDOCT) method was evaluated through flow models and porcine models, as well as through the correlation between ssDOCT algorithm and computational fluid dynamic (CFD) models. It was observed that ssDOCT provided improved Doppler artefact suppression over the conventional DOCT technique. ssDOCT also provided the ability to estimate lower velocities within the DOCT image to measure the hemodynamic patterns around stent struts in both the internal carotid and patient specific flow phantoms. An OCT
imaging study was also conducted consisting of surgically resected human intracranial aneurysms. Further enhancement of the detection of these key morphological structures was demonstrated by an optical-attenuation
imaging variant of OCT. The presented techniques could provide further insights to the cause of intracranial aneurysm rupture and vascular healing mechanisms.
Advisors/Committee Members: Yang, Victor, X. D. (Thesis advisor), Kolios, Michael C. (Thesis advisor).
Subjects/Keywords: Intracranial aneurysms; Optical coherence tomography; Neurovascular diseases – Imaging
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Manager
APA (6th Edition):
Vuong, B. (2014). Development of an Intravascular Doppler Optical Coherence Tomography Imaging Technique for
Neurovascular Applications. (Thesis). Ryerson University. Retrieved from https://digital.library.ryerson.ca/islandora/object/RULA%3A3799
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Vuong, Barry. “Development of an Intravascular Doppler Optical Coherence Tomography Imaging Technique for
Neurovascular Applications.” 2014. Thesis, Ryerson University. Accessed January 19, 2021.
https://digital.library.ryerson.ca/islandora/object/RULA%3A3799.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Vuong, Barry. “Development of an Intravascular Doppler Optical Coherence Tomography Imaging Technique for
Neurovascular Applications.” 2014. Web. 19 Jan 2021.
Vancouver:
Vuong B. Development of an Intravascular Doppler Optical Coherence Tomography Imaging Technique for
Neurovascular Applications. [Internet] [Thesis]. Ryerson University; 2014. [cited 2021 Jan 19].
Available from: https://digital.library.ryerson.ca/islandora/object/RULA%3A3799.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Vuong B. Development of an Intravascular Doppler Optical Coherence Tomography Imaging Technique for
Neurovascular Applications. [Thesis]. Ryerson University; 2014. Available from: https://digital.library.ryerson.ca/islandora/object/RULA%3A3799
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Manchester
30.
Arthur, Donna Louise.
Doppler Optical Coherence Tomography for Microcirculation
Studies.
Degree: 2014, University of Manchester
URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:216264
► This thesis forms part of an ongoing long-term project to investigate the suitability of Doppler optical coherence tomography (OCT) as a measurement tool to investigate…
(more)
▼ This thesis forms part of an ongoing long-term
project to investigate the suitability of Doppler optical
coherence
tomography (OCT) as a measurement tool to investigate skin
thickness and blood flow in patients with systemic sclerosis.There
is a discussion of the characterisation of an electro-optic phase
modulator for use in a Doppler OCT
imaging system which is being
built for the purpose of clinical studies. In addition to this the
development of software for the same system is described. The work
includes a comparison of two methods of obtaining Doppler
information that were tested with the system; a phase resolved
method and a correlation mapping method. Initial structural and
Doppler images obtained using the system are presented.In addition
to this the development of semi-automated software to measure skin
thickness from both OCT and high frequency ultrasound images is
discussed. The results of a study, for which this software was
developed, into skin thickness measurements using both techniques
in both patients with systemic sclerosis and healthy controls are
presented. Both OCT and high frequency ultrasound were able to
measure a statistically significant difference in epidermal
thickness at multiple locations on the body.Finally, the
modification of a freely available Monte Carlo simulation for light
propagation in multi-layered tissue (MCML) to enable the simulation
of structural and Doppler OCT images is covered. The simulation was
able to extract the magnitude of the simulated flow accurately to
within an order of magnitude, and after a simple filter was applied
to eliminate fluctuations in the data the structure of the Doppler
image closely matched what was modelled.
Advisors/Committee Members: HERRICK, ARIANE AL, MURRAY, ANDREA AK, Dickinson, Mark, Herrick, Ariane, Murray, Andrea.
Subjects/Keywords: OCT; Optical Coherence Tomography; Imaging; Doppler; Systemic sclerosis; Microcirculation
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Manager
APA (6th Edition):
Arthur, D. L. (2014). Doppler Optical Coherence Tomography for Microcirculation
Studies. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:216264
Chicago Manual of Style (16th Edition):
Arthur, Donna Louise. “Doppler Optical Coherence Tomography for Microcirculation
Studies.” 2014. Doctoral Dissertation, University of Manchester. Accessed January 19, 2021.
http://www.manchester.ac.uk/escholar/uk-ac-man-scw:216264.
MLA Handbook (7th Edition):
Arthur, Donna Louise. “Doppler Optical Coherence Tomography for Microcirculation
Studies.” 2014. Web. 19 Jan 2021.
Vancouver:
Arthur DL. Doppler Optical Coherence Tomography for Microcirculation
Studies. [Internet] [Doctoral dissertation]. University of Manchester; 2014. [cited 2021 Jan 19].
Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:216264.
Council of Science Editors:
Arthur DL. Doppler Optical Coherence Tomography for Microcirculation
Studies. [Doctoral Dissertation]. University of Manchester; 2014. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:216264
◁ [1] [2] [3] [4] [5] [6] [7] ▶
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Open Access Theses and Dissertations
