subject:(cocaine)

University of Georgia

1. Stramiello, Michael. Pharmacological and electrophysiological characterizations of dopaminergic modulation of long-term potentiation in the hippocampus CA1 region: implications for addiction.

Degree: PhD, Neuroscience, 2010, University of Georgia

URL: http://purl.galileo.usg.edu/uga_etd/stramiello_michael_201005_phd

► Over the past fifty years, our understanding of dopamine has evolved from a mere acknowledgement of its precursory status in norepinephrine production to the realization… (more)

Subjects/Keywords: cocaine

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APA (6^th Edition):

Stramiello, M. (2010). Pharmacological and electrophysiological characterizations of dopaminergic modulation of long-term potentiation in the hippocampus CA1 region: implications for addiction. (Doctoral Dissertation). University of Georgia. Retrieved from http://purl.galileo.usg.edu/uga_etd/stramiello_michael_201005_phd

Chicago Manual of Style (16^th Edition):

Stramiello, Michael. “Pharmacological and electrophysiological characterizations of dopaminergic modulation of long-term potentiation in the hippocampus CA1 region: implications for addiction.” 2010. Doctoral Dissertation, University of Georgia. Accessed August 16, 2018. http://purl.galileo.usg.edu/uga_etd/stramiello_michael_201005_phd.

MLA Handbook (7^th Edition):

Stramiello, Michael. “Pharmacological and electrophysiological characterizations of dopaminergic modulation of long-term potentiation in the hippocampus CA1 region: implications for addiction.” 2010. Web. 16 Aug 2018.

Vancouver:

Stramiello M. Pharmacological and electrophysiological characterizations of dopaminergic modulation of long-term potentiation in the hippocampus CA1 region: implications for addiction. [Internet] [Doctoral dissertation]. University of Georgia; 2010. [cited 2018 Aug 16]. Available from: http://purl.galileo.usg.edu/uga_etd/stramiello_michael_201005_phd.

Council of Science Editors:

Stramiello M. Pharmacological and electrophysiological characterizations of dopaminergic modulation of long-term potentiation in the hippocampus CA1 region: implications for addiction. [Doctoral Dissertation]. University of Georgia; 2010. Available from: http://purl.galileo.usg.edu/uga_etd/stramiello_michael_201005_phd

2. Kromrey, Sarah Allyson. Endogenous hormonal milieu of female cynomolgus monkeys: interaction with cognitive performance, social rank and acquisition of cocaine self-administration.

Degree: 2015, Wake Forest University

URL: http://hdl.handle.net/10339/57103

► There are currently no FDA-approved drug treatments for cocaine abuse. The use of female subjects and a better understanding of the influence of hormones and… (more)

Subjects/Keywords: cocaine

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APA (6^th Edition):

Kromrey, S. A. (2015). Endogenous hormonal milieu of female cynomolgus monkeys: interaction with cognitive performance, social rank and acquisition of cocaine self-administration. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/57103

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kromrey, Sarah Allyson. “Endogenous hormonal milieu of female cynomolgus monkeys: interaction with cognitive performance, social rank and acquisition of cocaine self-administration.” 2015. Thesis, Wake Forest University. Accessed August 16, 2018. http://hdl.handle.net/10339/57103.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kromrey, Sarah Allyson. “Endogenous hormonal milieu of female cynomolgus monkeys: interaction with cognitive performance, social rank and acquisition of cocaine self-administration.” 2015. Web. 16 Aug 2018.

Vancouver:

Kromrey SA. Endogenous hormonal milieu of female cynomolgus monkeys: interaction with cognitive performance, social rank and acquisition of cocaine self-administration. [Internet] [Thesis]. Wake Forest University; 2015. [cited 2018 Aug 16]. Available from: http://hdl.handle.net/10339/57103.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kromrey SA. Endogenous hormonal milieu of female cynomolgus monkeys: interaction with cognitive performance, social rank and acquisition of cocaine self-administration. [Thesis]. Wake Forest University; 2015. Available from: http://hdl.handle.net/10339/57103

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Utah

3. Riedy, Matthew D. Reinstatement of Cocaine-Seeking Behavior Induced by Discrete Sensory Cues and the Associated Immediate Early Gene Expression.

Degree: PhD, Neurosurgery;, 2010, University of Utah

URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/442/rec/969

► Drug addiction is a serious problem for modern societies worldwide. There are remarkable costs associated with this problem, from the direct costs of the substance… (more)

▼ Drug addiction is a serious problem for modern societies worldwide. There are remarkable costs associated with this problem, from the direct costs of the substance abuse treatment and prevention healthcare infrastructure to the less direct implications for the criminal justice system and social welfare programs. For individuals there is a loss of health, livelihood, interpersonal relationships, freedom, and ultimately life. The hallmark behavioral feature of addiction is a pattern of intermittent relapse lasting for decades after initial substance abuse. The research community has made a substantial investment of time and resources to better understand the etiology and fundamental features underlying addiction and relapse. Modern theories posit that addiction involves a recurring compulsion by an individual to engage in drug-seeking and drug-taking behaviors despite significant negative consequences. In humans, exposure to drug-associated stimuli and environmental contexts is known to induce an intense state of craving, independent of the length of time since acute drug exposure. Furthermore, neuroimaging studies of humans have suggested that basal ganglia structures may be involved in craving. Progress in the study of basal ganglia-mediated learning and memory has begun to outline a neuroanatomical substrate for the transition of egocentric, selfinitiated goal-directed behavior, to allocentric or externally driven behavior arising from exposure to environmental contexts or particular stimuli. While many elegant experiments have addressed the ability of drug-associated environmental contexts to affect behavior, the ability of discrete drug-associated sensory cues to affect behavior has been less thoroughly addressed. Discrete cues can become associated with drug use by two major operant learning mechanisms that vary in their temporal relationship to the subjective perception of primary reinforcement. The experiments described in this dissertation were designed to identify the extent to which discriminative stimuli and conditioned reinforcers activate the same or different populations of neurons in the dorsal striatum, the main input nucleus of the mammalian basal ganglia. This work has examined, in a novel experimental model of relapse, the capability of discrete sensory cues to elicit reinstatement of drug-seeking behavior and the expression of learning and memory related genes associated with this behavior.

Subjects/Keywords: Cocaine Abuse

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Riedy, M. D. (2010). Reinstatement of Cocaine-Seeking Behavior Induced by Discrete Sensory Cues and the Associated Immediate Early Gene Expression. (Doctoral Dissertation). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/442/rec/969

Chicago Manual of Style (16^th Edition):

Riedy, Matthew D. “Reinstatement of Cocaine-Seeking Behavior Induced by Discrete Sensory Cues and the Associated Immediate Early Gene Expression.” 2010. Doctoral Dissertation, University of Utah. Accessed August 16, 2018. http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/442/rec/969.

MLA Handbook (7^th Edition):

Riedy, Matthew D. “Reinstatement of Cocaine-Seeking Behavior Induced by Discrete Sensory Cues and the Associated Immediate Early Gene Expression.” 2010. Web. 16 Aug 2018.

Vancouver:

Riedy MD. Reinstatement of Cocaine-Seeking Behavior Induced by Discrete Sensory Cues and the Associated Immediate Early Gene Expression. [Internet] [Doctoral dissertation]. University of Utah; 2010. [cited 2018 Aug 16]. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/442/rec/969.

Council of Science Editors:

Riedy MD. Reinstatement of Cocaine-Seeking Behavior Induced by Discrete Sensory Cues and the Associated Immediate Early Gene Expression. [Doctoral Dissertation]. University of Utah; 2010. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/442/rec/969

Texas Tech University

4. Vaz, Berchman Austin. Effects of cocaine on macrophage functions: Phagocytosis and activation to the cytotoxic state.

Degree: TTUHSC – Immunology and Infectious Diseases, 1993, Texas Tech University

URL: http://hdl.handle.net/2346/17917

► One of the most "fashionable" as well as dangerous drugs abused in this country is cocaine. Very little is known about the effects of cocaine… (more)

▼ One of the most "fashionable" as well as dangerous drugs abused in this country is cocaine. Very little is known about the effects of cocaine on the immune system. Since macrophages play a central role in both the cellular and the humoral arms of the immune system, this study focused on the effects of cocaine on murine peritoneal macrophage functions, viz., phagocytosis and activation to the cytotoxic state. Phagocytosis is one of the most important components of the host defenses against invading microorganisms once the outer epithelial surface of the body has been breached. In the present study, cocaine injected intraperitoneally was found to increase phagocytic activity of isolated macrophages in vitro; but decreased it when measured by an in vivo assay. The respiratory burst, which is usually correlated with phagocytosis, was enhanced by cocaine. Macrophage activation was studied by measuring macrophage- mediated cytotoxicity (MMC), i.e., the acquisition of competence to destroy neoplastic cells in the absence of antibody. Macrophages from cocaine-injected mice demonstrated a reduced capacity for killing neoplastic cells; as well as a reduction in the secretion of reactive nitrogen intermediates. The latter represent a major product used by macrophages to kill cells. Macrophage receptors/ surface proteins involved in phagocytosis and activation were studied using flow cytometry. A number of these surface receptors were dramatically altered by exposure to cocaine. The presumed toxic metabolites of cocaine, benzoylecgonine and norcocaine, were found to have similar effects on macrophage functions. The present studies clearly demonstrate that cocaine affeas phagocytosis and activation to the cytotoxic state. This translates into impairment of certain non-specific immune responses. These results taken in their entirety suggest that the ability of cocaine to alter macrophage functions could modify specific immune responses resulting in a compromised immune system.

Subjects/Keywords: Cocaine

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Vaz, B. A. (1993). Effects of cocaine on macrophage functions: Phagocytosis and activation to the cytotoxic state. (Doctoral Dissertation). Texas Tech University. Retrieved from http://hdl.handle.net/2346/17917

Chicago Manual of Style (16^th Edition):

Vaz, Berchman Austin. “Effects of cocaine on macrophage functions: Phagocytosis and activation to the cytotoxic state.” 1993. Doctoral Dissertation, Texas Tech University. Accessed August 16, 2018. http://hdl.handle.net/2346/17917.

MLA Handbook (7^th Edition):

Vaz, Berchman Austin. “Effects of cocaine on macrophage functions: Phagocytosis and activation to the cytotoxic state.” 1993. Web. 16 Aug 2018.

Vancouver:

Vaz BA. Effects of cocaine on macrophage functions: Phagocytosis and activation to the cytotoxic state. [Internet] [Doctoral dissertation]. Texas Tech University; 1993. [cited 2018 Aug 16]. Available from: http://hdl.handle.net/2346/17917.

Council of Science Editors:

Vaz BA. Effects of cocaine on macrophage functions: Phagocytosis and activation to the cytotoxic state. [Doctoral Dissertation]. Texas Tech University; 1993. Available from: http://hdl.handle.net/2346/17917

5. Hamilton, Lindsey Rebecca. Neurobiological and Behavioral Phenotypes and Cocaine Self-Administration in Adult Rhesus Monkeys Exposed to Cocaine Throughout Gestation.

Degree: 2010, Wake Forest University

URL: http://hdl.handle.net/10339/30400

Maternal cocaine addiction is a significant public health problem yet

Subjects/Keywords: Cocaine

…Figure 2. A) Yawning Elicited by Quinpirole in Female  Prenatally Cocaine Exposed and… …Control  Monkeys  B) Yawning Elicited by Quinpirole in Male  Prenatally Cocaine Exposed and… …Peak Yawns Elicited by Quinpirole  and Maximal Daily Dose of In Utero Cocaine  107… …Effects of SKF 81297 on Eye‐Blinking Rates in  Prenatally Cocaine Exposed Monkeys  C) Group… …Delay Value �� Percentage Choice for  the Delayed Reinforcer Curves for a Prenatally  Cocaine…

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APA (6^th Edition):

Hamilton, L. R. (2010). Neurobiological and Behavioral Phenotypes and Cocaine Self-Administration in Adult Rhesus Monkeys Exposed to Cocaine Throughout Gestation. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/30400

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hamilton, Lindsey Rebecca. “Neurobiological and Behavioral Phenotypes and Cocaine Self-Administration in Adult Rhesus Monkeys Exposed to Cocaine Throughout Gestation.” 2010. Thesis, Wake Forest University. Accessed August 16, 2018. http://hdl.handle.net/10339/30400.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hamilton, Lindsey Rebecca. “Neurobiological and Behavioral Phenotypes and Cocaine Self-Administration in Adult Rhesus Monkeys Exposed to Cocaine Throughout Gestation.” 2010. Web. 16 Aug 2018.

Vancouver:

Hamilton LR. Neurobiological and Behavioral Phenotypes and Cocaine Self-Administration in Adult Rhesus Monkeys Exposed to Cocaine Throughout Gestation. [Internet] [Thesis]. Wake Forest University; 2010. [cited 2018 Aug 16]. Available from: http://hdl.handle.net/10339/30400.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hamilton LR. Neurobiological and Behavioral Phenotypes and Cocaine Self-Administration in Adult Rhesus Monkeys Exposed to Cocaine Throughout Gestation. [Thesis]. Wake Forest University; 2010. Available from: http://hdl.handle.net/10339/30400

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Wake Forest University

6. Freeman, Willard Morgan. Functional Neurogenomics of Cocaine.

Degree: 2002, Wake Forest University

URL: http://hdl.handle.net/10339/14669

► Dissertation prepared under the direction of Kent E. Vrana, Ph.D., Associate Professor of Physiology and Pharmacology and Director of Graduate Studies Chronic cocaine abuse causes… (more)

▼ Dissertation prepared under the direction of Kent E. Vrana, Ph.D., Associate Professor of Physiology and Pharmacology and Director of Graduate Studies Chronic cocaine abuse causes altered neuronal gene expression, morphology, and physiology. These changes are thought to contribute to an allostatic state of behavior characterized by compulsive drug seeking, sensitization, tolerance, withdrawal and psychological dependence. Through the use of cDNA hybridization arrays and immunoreactive protein quantification, gene expression analysis can be carried out on a functional neurogenomic scale. This dissertation research identifies changes in gene expression across three animal models of chronic cocaine administration (non-contigent non-human primate, non-contingent rat, and self-administering rat), and three brain regions, (nucleus accumbens, frontal cortex, and hippocampus). In the non-human primate, chronic cocaine induced the expression of protein tyrosine kinase 2, mitogen activated protein kinase kinase, â-catenin, and protein kinase A á catalytic subunit. While each of these genes has important cellular effects, the prime finding of the study was that they all serve to activate cyclic AMP response element binding protein or activator protein 1, known mediators of cocaine-responsive gene expression x and behavior. In the non-contingent rodent model, hippocampal expression of protein kinase Cá, protein kinase Cå, metabotropic glutamate receptor 5, potassium channel Kv1.1, protein tyrosine kinase 2, and â-catenin were induced by cocaine. Each of these genes could potentially have a number of effects, but, interestingly, some of the changes observed could act in an antagonistic manner. In the rat frontal cortex, induction of protein tyrosine kinase 2, activity-regulated cytoskeletal protein, and a nuclear receptor 77 related antigen were seen with chronic cocaine administration. In the rat nucleus accumbens, protein tyrosine kinase 2 protein was shown to be significantly up-regulated. Initial hybridization array analysis of cocaine self-administering rats has produced a number of potentially cocaineresponsive genes, some of which were observed in the non-contingent rat model. These studies demonstrate that some changes in gene expression are specific to certain regions of the brain and others are more ubiquitous. These changes in gene expression provide hypotheses for future research into the role of functional neurogenomics in physiology and behavior, and may provide potential targets for pharmacotherapeutic intervention.

Subjects/Keywords: Cocaine

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Freeman, W. M. (2002). Functional Neurogenomics of Cocaine. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/14669

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Freeman, Willard Morgan. “Functional Neurogenomics of Cocaine.” 2002. Thesis, Wake Forest University. Accessed August 16, 2018. http://hdl.handle.net/10339/14669.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Freeman, Willard Morgan. “Functional Neurogenomics of Cocaine.” 2002. Web. 16 Aug 2018.

Vancouver:

Freeman WM. Functional Neurogenomics of Cocaine. [Internet] [Thesis]. Wake Forest University; 2002. [cited 2018 Aug 16]. Available from: http://hdl.handle.net/10339/14669.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Freeman WM. Functional Neurogenomics of Cocaine. [Thesis]. Wake Forest University; 2002. Available from: http://hdl.handle.net/10339/14669

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

7. Pattison, Lindsey Patricia. Functional Alterations in the Dopamine Transporter of Rodents following Self-Administration of Cocaine, Heroin and Speedball.

Degree: 2013, Wake Forest University

URL: http://hdl.handle.net/10339/38519

► Cocaine/heroin combinations (speedball) induce a synergistic elevation in extracellular dopamine (DA) concentrations ([DA]_e) in the nucleus accumbens (NAc) that can explain the continued patterns of… (more)

Subjects/Keywords: cocaine

…CHAPTER I Table 1. Effects of cocaine on the mesolimbic DA system Table 2. Compounds used… …combinations to elucidate mechanisms 23 of cocaine/heroin 40 CHAPTER II Figure 1… …Representative traces of evoked DA signals detected by FSCV in rat NAc before and 1 min after cocaine… …cocaine + 0.03 mg/kg heroin, i.v.) injection in drug-naïve animals (upper panel)… …cocaine (1.0 mg/kg), heroin (0.03 mg/kg) and speedball (1.0 mg/kg…

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APA (6^th Edition):

Pattison, L. P. (2013). Functional Alterations in the Dopamine Transporter of Rodents following Self-Administration of Cocaine, Heroin and Speedball. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/38519

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Pattison, Lindsey Patricia. “Functional Alterations in the Dopamine Transporter of Rodents following Self-Administration of Cocaine, Heroin and Speedball.” 2013. Thesis, Wake Forest University. Accessed August 16, 2018. http://hdl.handle.net/10339/38519.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Pattison, Lindsey Patricia. “Functional Alterations in the Dopamine Transporter of Rodents following Self-Administration of Cocaine, Heroin and Speedball.” 2013. Web. 16 Aug 2018.

Vancouver:

Pattison LP. Functional Alterations in the Dopamine Transporter of Rodents following Self-Administration of Cocaine, Heroin and Speedball. [Internet] [Thesis]. Wake Forest University; 2013. [cited 2018 Aug 16]. Available from: http://hdl.handle.net/10339/38519.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pattison LP. Functional Alterations in the Dopamine Transporter of Rodents following Self-Administration of Cocaine, Heroin and Speedball. [Thesis]. Wake Forest University; 2013. Available from: http://hdl.handle.net/10339/38519

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

8. Brutcher, Robert Edwin. EFFECTS OF SLEEP DISRUPTION AND QUETIAPINE ON COCAINE ABUSE: THE PATH TO DEVELOPMENT OF A MONKEY MODEL OF PTSD.

Degree: 2013, Wake Forest University

URL: http://hdl.handle.net/10339/38531

► The goal of the current research is to systematically evaluate several components needed to develop a monkey model of post-traumatic stress disorder (PTSD). For this… (more)

Subjects/Keywords: Cocaine

…LIST OF FIGURES PAGE CHAPTER II Figure 1. Mean (± SD or SEM) cocaine-choice… …cocaine doses on (A) sleep efficiency, (B) sleep latency, and (C)… …cocaine baseline (A) and sleep disruption (B) �� …100 Figure 4. Mean (… …SEM) sleep measures during baseline cocaine conditions (light gray bars) and… …p < 0.01; n=7 �� …101 Figure 4. Mean (± SEM) percent of cocaine choice for…

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APA (6^th Edition):

Brutcher, R. E. (2013). EFFECTS OF SLEEP DISRUPTION AND QUETIAPINE ON COCAINE ABUSE: THE PATH TO DEVELOPMENT OF A MONKEY MODEL OF PTSD. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/38531

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Brutcher, Robert Edwin. “EFFECTS OF SLEEP DISRUPTION AND QUETIAPINE ON COCAINE ABUSE: THE PATH TO DEVELOPMENT OF A MONKEY MODEL OF PTSD.” 2013. Thesis, Wake Forest University. Accessed August 16, 2018. http://hdl.handle.net/10339/38531.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Brutcher, Robert Edwin. “EFFECTS OF SLEEP DISRUPTION AND QUETIAPINE ON COCAINE ABUSE: THE PATH TO DEVELOPMENT OF A MONKEY MODEL OF PTSD.” 2013. Web. 16 Aug 2018.

Vancouver:

Brutcher RE. EFFECTS OF SLEEP DISRUPTION AND QUETIAPINE ON COCAINE ABUSE: THE PATH TO DEVELOPMENT OF A MONKEY MODEL OF PTSD. [Internet] [Thesis]. Wake Forest University; 2013. [cited 2018 Aug 16]. Available from: http://hdl.handle.net/10339/38531.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Brutcher RE. EFFECTS OF SLEEP DISRUPTION AND QUETIAPINE ON COCAINE ABUSE: THE PATH TO DEVELOPMENT OF A MONKEY MODEL OF PTSD. [Thesis]. Wake Forest University; 2013. Available from: http://hdl.handle.net/10339/38531

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Victoria University of Wellington

9. Morani, Aashish Sultan. Behavioural Pharmacology of Novel Kappa Opioid Compounds.

Degree: 2011, Victoria University of Wellington

URL: http://hdl.handle.net/10063/4446

► Rationale: Kappa opioid receptor (KOPr) activation by traditional agonists has been shown to produce anti-addiction behaviours. However, adverse effects such as sedation, aversion and depression… (more)

▼ Rationale: Kappa opioid receptor (KOPr) activation by traditional agonists has been shown to produce anti-addiction behaviours. However, adverse effects such as sedation, aversion and depression have limited their clinical development. Recently, salvinorin A (Sal A), an active component of the plant Salvia divinorum was shown to be a potent and selective KOPr agonist. Sal A has a short duration of effect and quick onset of action. It also produces similar behavioural pharmacology to traditional KOPr agonists. However, little is known about the anti-addiction profile of Sal A. If Sal A and its structural analogues produce anti-addiction properties with fewer adverse effects compared to traditional KOPr agonists, they have potential to be developed into antiaddiction pharmacotherapies. Therefore, Sal A and its structural analogues (DS1, MOM Sal B, EOM Sal B, herkinorin) and Mu opioid receptor (MOPr) antagonist/partial KOPr agonist, nalmefene were tested for their behavioural anti-addiction and adverse effect profiles in rats. Methods: To test the anti-addiction profile, a within session cocaine prime induced reinstatement paradigm was used. The selectivity of KOPr agonists in attenuating cocaine seeking behaviours was tested using sucrose reinforcement (anhedonia) and cocaine induced hyperactivity in self-administering rats (sedation during reinstatement test). Furthermore, behavioural adverse effects were screened using spontaneous open field activity (motor suppression), conditioned taste aversion (aversion) and forced swim test (depression) in rats. To further quantify the anti-addiction behaviours, the effect of KOPr agonists which attenuated drug seeking selectively without producing motor suppression by themselves were tested for cocaine produced motor function (hyperactivity and behavioural sensitization) in rats. The effect of serotonin transporter blockade on KOPr agonist induced depressive behaviour was also tested. The effects of KOPr activation on in vitro serotonin transporter function were also determined. Results: Sal A, DS1 and nalmefene attenuated cocaine prime induced drug-seeking, in a selective manner, via KOPr activation. MOM Sal B, a more potent and long acting Sal A analogue attenuated cocaine seeking in a non-selective manner. Sal A, DS1 and nalmefene did not induce aversion, however nalmefene suppressed motor function, which was not seen with Sal A and DS1. Furthermore, Sal A and DS1 suppressed cocaine behavioural sensitization. All three compounds (Sal A, DS1, nalmefene) produced depression. The depressive effects produced by Sal A and DS1 were diminished by blocking the serotonin transporter. Live-cell serotonin transporter assays showed potential differences between traditional (U50488H) and novel (Sal A, DS1) KOPr agonists in their ability to modulate serotonin transporter function. Conclusion: Out of six KOPr compounds tested, Sal A, DS1, MOM Sal B and nalmefene produced anti-addiction behaviours. However, MOM Sal B exposure also suppressed natural reward seeking behaviour. Sal A and DS1… Advisors/Committee Members: Kivell, Bronwyn, Schenk, Susan.

Subjects/Keywords: Cocaine; Salvinorin; Pharmacology

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APA (6^th Edition):

Morani, A. S. (2011). Behavioural Pharmacology of Novel Kappa Opioid Compounds. (Doctoral Dissertation). Victoria University of Wellington. Retrieved from http://hdl.handle.net/10063/4446

Chicago Manual of Style (16^th Edition):

Morani, Aashish Sultan. “Behavioural Pharmacology of Novel Kappa Opioid Compounds.” 2011. Doctoral Dissertation, Victoria University of Wellington. Accessed August 16, 2018. http://hdl.handle.net/10063/4446.

MLA Handbook (7^th Edition):

Morani, Aashish Sultan. “Behavioural Pharmacology of Novel Kappa Opioid Compounds.” 2011. Web. 16 Aug 2018.

Vancouver:

Morani AS. Behavioural Pharmacology of Novel Kappa Opioid Compounds. [Internet] [Doctoral dissertation]. Victoria University of Wellington; 2011. [cited 2018 Aug 16]. Available from: http://hdl.handle.net/10063/4446.

Council of Science Editors:

Morani AS. Behavioural Pharmacology of Novel Kappa Opioid Compounds. [Doctoral Dissertation]. Victoria University of Wellington; 2011. Available from: http://hdl.handle.net/10063/4446

University of Michigan

10. Brim, Remy Leigh. Investigations into the Therapeutic Potential of a Bacterial Cocaine Esterase for the Treatment of Cocaine Toxicity and Cocaine Abuse.

Degree: PhD, Pharmacology, 2011, University of Michigan

URL: http://hdl.handle.net/2027.42/84448

► Cocaine use is a widespread problem in the United States with 2 million current users who make about half a million emergency department visits each… (more)

▼ Cocaine use is a widespread problem in the United States with 2 million current users who make about half a million emergency department visits each year. Although use is prevalent, there is currently no FDA-approved pharmacotherapy to specifically treat cocaine abuse or cocaine toxicity. Approaches toward developing therapies for these indications include small molecule inhibitors of cocaine binding and cocaine vaccines. These methods have proven to block the strong reinforcing properties of the drug; however, they do not prevent nor reverse cocaine’s serious physiological effects. Our approach to treating cocaine toxicity and abuse is to rapidly hydrolyze the cocaine molecule into inactive metabolites using a bacterial cocaine esterase (CocE), thus eliminating cocaine’s harmful and strong reinforcing effects. This work has taken major steps toward developing CocE into a viable pharmacotherapy for both cocaine addiction and toxicity. Initially two thermostabilizing mutations were combined to improve the half-life of CocE. This mutant was pharmacologically characterized in vitro as well as in vivo using rodent models of cocaine lethality and reinforcement. The pharmacodynamic and pharmacokinetic properties of CocE, including in vivo rates of cocaine hydrolysis across species, circulating half-life, and mechanisms of elimination, were assessed. CocE’s capacity to hydrolyze cocaine in the presence of commonly co-abused drugs, and its capacity to hydrolyze active cocaine metabolites were investigated. The results from these studies support the notion that cocaine esterase displays strong therapeutic potential, and that it may proceed towards clinical development. Moreover, it is a comprehensive analysis of how protein biologics may be used as effective pharmacotherapeutics. Advisors/Committee Members: Sunahara, Roger K. (committee member), Woods, James H. (committee member), Gnegy, Margaret E. (committee member), Lukacs, Nicholas W. (committee member), Tesmer, John (committee member).

Subjects/Keywords: Cocaine; Protein-based Theraputic; Cocaine Esterase; Cocaine Abuse; Cocaine Toxicity; Pharmacy and Pharmacology; Health Sciences

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APA (6^th Edition):

Brim, R. L. (2011). Investigations into the Therapeutic Potential of a Bacterial Cocaine Esterase for the Treatment of Cocaine Toxicity and Cocaine Abuse. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/84448

Chicago Manual of Style (16^th Edition):

Brim, Remy Leigh. “Investigations into the Therapeutic Potential of a Bacterial Cocaine Esterase for the Treatment of Cocaine Toxicity and Cocaine Abuse.” 2011. Doctoral Dissertation, University of Michigan. Accessed August 16, 2018. http://hdl.handle.net/2027.42/84448.

MLA Handbook (7^th Edition):

Brim, Remy Leigh. “Investigations into the Therapeutic Potential of a Bacterial Cocaine Esterase for the Treatment of Cocaine Toxicity and Cocaine Abuse.” 2011. Web. 16 Aug 2018.

Vancouver:

Brim RL. Investigations into the Therapeutic Potential of a Bacterial Cocaine Esterase for the Treatment of Cocaine Toxicity and Cocaine Abuse. [Internet] [Doctoral dissertation]. University of Michigan; 2011. [cited 2018 Aug 16]. Available from: http://hdl.handle.net/2027.42/84448.

Council of Science Editors:

Brim RL. Investigations into the Therapeutic Potential of a Bacterial Cocaine Esterase for the Treatment of Cocaine Toxicity and Cocaine Abuse. [Doctoral Dissertation]. University of Michigan; 2011. Available from: http://hdl.handle.net/2027.42/84448

University of Texas – Austin

11. Will, Ryan Gregory. The role of the preoptic area in response to cocaine.

Degree: Psychology, 2016, University of Texas – Austin

URL: http://hdl.handle.net/2152/39723

► The preoptic area of the hypothalamus is ideally suited to modulate the behavioral and neural response to drugs of abuse such as cocaine. The preoptic… (more)

Subjects/Keywords: Preoptic area; Cocaine

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APA (6^th Edition):

Will, R. G. (2016). The role of the preoptic area in response to cocaine. (Thesis). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/39723

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Will, Ryan Gregory. “The role of the preoptic area in response to cocaine.” 2016. Thesis, University of Texas – Austin. Accessed August 16, 2018. http://hdl.handle.net/2152/39723.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Will, Ryan Gregory. “The role of the preoptic area in response to cocaine.” 2016. Web. 16 Aug 2018.

Vancouver:

Will RG. The role of the preoptic area in response to cocaine. [Internet] [Thesis]. University of Texas – Austin; 2016. [cited 2018 Aug 16]. Available from: http://hdl.handle.net/2152/39723.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Will RG. The role of the preoptic area in response to cocaine. [Thesis]. University of Texas – Austin; 2016. Available from: http://hdl.handle.net/2152/39723

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

12. Puig, Stéphanie. Etude intégrée des variations comportementales, neurochimiques et cellulaires de la cocaïne : Analyse des variations à court et à long terme : Importance du profil d’administration et anticipation de l’effet renforçant de la drogue : Integrated study of variations behavioral, neurochemical and cellular of the cocaine.

Degree: Docteur es, Neurosciences, 2012, Université Paris Descartes – Paris V

URL: http://www.theses.fr/2012PA05P620

►

La prise répétée de cocaïne entraine la mise en place d’une addiction durable. Cette maladie neuropsychiatrique est un problème de santé public majeur en France… (more)

▼

La prise répétée de cocaïne entraine la mise en place d’une addiction durable. Cette maladie neuropsychiatrique est un problème de santé public majeur en France et dans le monde. Les effets aigus de la cocaïne sont maintenant bien connus mais il est encore difficile d’établir un consensus des conséquences d’une administration répétée de ce psychostimulant au niveau central. En effet, les résultats rapportés dans la littérature actuelle présentent de nombreuses disparités. Nous pensons que cela pourrait être dû aux différences de protocole d’administration utilisés par chaque laboratoire. Nous émettons l’hypothèse que si à l’heure actuelle il n’existe pas de traitement efficace pour traiter les cocaïnomanes, c’est que les thérapies ne prennent pas en compte les différentes modifications neurobiologiques induites par les différents profils de consommation. Afin de tester cette hypothèse, nous avons comparé deux profils d’administration différents de cocaïne chez le rat. Nous nous sommes intéressés aux conséquences comportementales, neurochimiques et cellulaires après un sevrage court et un sevrage long. Nous avons mis en évidence que les adaptations comportementales (activité locomotrice et exploratoire), neurochimiques (dopamine extracellulaire) et cellulaires (récepteurs dopaminergiques) basales et en réponse à une dose de rappel, sont différentes selon le profil d’administration de cocaïne. Nous avons également mis en évidence une anticipation neurochimique dopaminergique et locomotrice, exactement à l’heure habituelle d’injection et qui varie selon le profil d’administration. Dans un deuxième temps, nous avons montré que le BDNF (Brain Derived Neurotrophic Factor), qui est une neurotrophine du système catécholaminergique, varie à la fois au niveau central et au niveau périphérique, de façon spécifique pour chaque profil d’administration de cocaïne. L’utilisation en clinique de ce biomarqueur périphérique (BDNF), permettrait d’évaluer les variations neurobiologiques centrales chez les patients cocaïnomanes et d’établir un traitement thérapeutique approprié à leur profil de consommation. L’ensemble des résultats obtenus au cours de cette thèse, ont permis de montrer que le profil d’administration a une grande importance sur les conséquences neurobiologiques de la cocaïne

Pas de résumé en anglais

Advisors/Committee Members: Noble, Florence (thesis director).

Subjects/Keywords: Cocaïne; Cocaine; 612.804 2

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APA (6^th Edition):

Puig, S. (2012). Etude intégrée des variations comportementales, neurochimiques et cellulaires de la cocaïne : Analyse des variations à court et à long terme : Importance du profil d’administration et anticipation de l’effet renforçant de la drogue : Integrated study of variations behavioral, neurochemical and cellular of the cocaine. (Doctoral Dissertation). Université Paris Descartes – Paris V. Retrieved from http://www.theses.fr/2012PA05P620

Chicago Manual of Style (16^th Edition):

Puig, Stéphanie. “Etude intégrée des variations comportementales, neurochimiques et cellulaires de la cocaïne : Analyse des variations à court et à long terme : Importance du profil d’administration et anticipation de l’effet renforçant de la drogue : Integrated study of variations behavioral, neurochemical and cellular of the cocaine.” 2012. Doctoral Dissertation, Université Paris Descartes – Paris V. Accessed August 16, 2018. http://www.theses.fr/2012PA05P620.

MLA Handbook (7^th Edition):

Puig, Stéphanie. “Etude intégrée des variations comportementales, neurochimiques et cellulaires de la cocaïne : Analyse des variations à court et à long terme : Importance du profil d’administration et anticipation de l’effet renforçant de la drogue : Integrated study of variations behavioral, neurochemical and cellular of the cocaine.” 2012. Web. 16 Aug 2018.

Vancouver:

Puig S. Etude intégrée des variations comportementales, neurochimiques et cellulaires de la cocaïne : Analyse des variations à court et à long terme : Importance du profil d’administration et anticipation de l’effet renforçant de la drogue : Integrated study of variations behavioral, neurochemical and cellular of the cocaine. [Internet] [Doctoral dissertation]. Université Paris Descartes – Paris V; 2012. [cited 2018 Aug 16]. Available from: http://www.theses.fr/2012PA05P620.

Council of Science Editors:

Puig S. Etude intégrée des variations comportementales, neurochimiques et cellulaires de la cocaïne : Analyse des variations à court et à long terme : Importance du profil d’administration et anticipation de l’effet renforçant de la drogue : Integrated study of variations behavioral, neurochemical and cellular of the cocaine. [Doctoral Dissertation]. Université Paris Descartes – Paris V; 2012. Available from: http://www.theses.fr/2012PA05P620

Temple University

13. Craige, Caryne. Regulation of Cocaine-induced Behaviors and Anxiety Produced by Cocaine Withdrawal through the Serotonin(2C) Receptor.

Degree: PhD, 2013, Temple University

URL: http://digital.library.temple.edu/u?/p245801coll10,239587

►

Pharmacology

Cocaine is a powerfully active psychostimulant which exerts its effects through blockade of dopamine, serotonin and norepinephrine transporters and resultant increases in extracellular levels… (more)

▼

Pharmacology

Cocaine is a powerfully active psychostimulant which exerts its effects through blockade of dopamine, serotonin and norepinephrine transporters and resultant increases in extracellular levels of these neurotransmitters. Much of the focus on cocaine abuse in the literature has been directed towards study of the dopamine system; however, several studies have identified a role for the serotonin system in regulating the rewarding effects of cocaine as well. Specifically, the serotonin 2C (5-HT2C) receptor regulates cocaine-induced alterations in serotonin and dopamine levels in an inhibitory manner, and 5-HT2C receptor agonist treatment attenuates cocaine-induced behaviors like self-administration. In the first aspect of the current thesis study, the effects of activation of 5-HT2C receptors on cocaine-induced conditioned place preference and behavioral sensitization were assessed. It was found that pretreatment with a 5-HT2C receptor agonist, Ro 60-0175, on cocaine (10 mg/kg) conditioning days of the conditioned place preference paradigm, attenuated the development of conditioned place preference in a dose-dependent manner. These results suggest that activation of 5-HT2C receptors inhibits the euphoric effects elicited by cocaine. Behavioral sensitization studies demonstrated that pretreatment with Ro 60-0175 prior to cocaine (10 mg/kg) over a 5 day period attenuated cocaine-induced hyperactivity. When injected with a cocaine challenge injection 10 days after the last cocaine injection, mice pretreated with Ro 60-0175 demonstrated lower levels of locomotor activity as compared to saline pretreated, cocaine-injected mice. This portion of the first study demonstrated that 5-HT2C receptor activity attenuated acute cocaine-induced conditioned reward, hyperactivity and the development of long-term alterations of cocaine exposure, as measured by behavioral sensitization. The second aspect of the current study focused on the regulation of anxiety produced by withdrawal from chronic cocaine administration. Anxiety during cocaine withdrawal is a component of the negative affective state often experienced by cocaine-dependent individuals during abstinence from drug use. Anxiety during cocaine withdrawal is likely to increase an individual's susceptibility to relapse to drug use in alleviation of this negative symptom. Studies have shown a downregulation of the serotonin and dopamine systems during withdrawal that potentially contributes to anxiety symptoms. As the 5-HT2C receptor exerts inhibitory control over both the serotonin and dopamine systems, it was hypothesized that blockade of 5-HT2C receptors would attenuate anxiety-like behavior during cocaine withdrawal. Previous studies have identified co-localization of 5-HT2C receptors on inhibitory gamma-aminobutyric acid (GABA) neurons, thus it was hypothesized that a 5-HT2C receptor-GABA mediated mechanism would be involved in the regulation of anxiety during withdrawal. The dorsal raphe brain region was targeted in these studies, as this region is the primary…

Advisors/Committee Members: Unterwald, Ellen M., Kirby, Lynn;, Bangasser, Debra, Dun, Nae J., Rawls, Scott M., Beck, Sheryl G.;.

Subjects/Keywords: Neurosciences; Pharmacology;

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APA (6^th Edition):

Craige, C. (2013). Regulation of Cocaine-induced Behaviors and Anxiety Produced by Cocaine Withdrawal through the Serotonin(2C) Receptor. (Doctoral Dissertation). Temple University. Retrieved from http://digital.library.temple.edu/u?/p245801coll10,239587

Chicago Manual of Style (16^th Edition):

Craige, Caryne. “Regulation of Cocaine-induced Behaviors and Anxiety Produced by Cocaine Withdrawal through the Serotonin(2C) Receptor.” 2013. Doctoral Dissertation, Temple University. Accessed August 16, 2018. http://digital.library.temple.edu/u?/p245801coll10,239587.

MLA Handbook (7^th Edition):

Craige, Caryne. “Regulation of Cocaine-induced Behaviors and Anxiety Produced by Cocaine Withdrawal through the Serotonin(2C) Receptor.” 2013. Web. 16 Aug 2018.

Vancouver:

Craige C. Regulation of Cocaine-induced Behaviors and Anxiety Produced by Cocaine Withdrawal through the Serotonin(2C) Receptor. [Internet] [Doctoral dissertation]. Temple University; 2013. [cited 2018 Aug 16]. Available from: http://digital.library.temple.edu/u?/p245801coll10,239587.

Council of Science Editors:

Craige C. Regulation of Cocaine-induced Behaviors and Anxiety Produced by Cocaine Withdrawal through the Serotonin(2C) Receptor. [Doctoral Dissertation]. Temple University; 2013. Available from: http://digital.library.temple.edu/u?/p245801coll10,239587

University of Florida

14. Marusich, Julie. Pharmacological and Environmental Factors in the Development of Contingent Tolerance to Cocaine in Pigeons.

Degree: Psychology, 2008, University of Florida

URL: http://ufdc.ufl.edu/UFE0022416

► Drug tolerance, a loss of drug effect relative to initial impact, is a common outcome of effects of repeated cocaine administration on operant behavior in… (more)

▼ Drug tolerance, a loss of drug effect relative to initial impact, is a common outcome of effects of repeated cocaine administration on operant behavior in humans and nonhumans. Previous research with rats and monkeys has shown that tolerance to behavioral effects of cocaine develops if the drug is administered before behavioral test sessions but does not if it is administered after sessions, an outcome which is referred to as contingent tolerance. Many experiments have found contingent tolerance, except a recent experiment using pigeons. The results of that study suggested that pigeons might develop tolerance to effects of cocaine regardless of whether the drug was administered before or after behavioral test sessions. The current set of experiments focused on environmental and pharmacological factors in the development of contingent tolerance to cocaine in pigeons by examining various relations between time of drug administration and the conduct of behavioral test sessions. Experiment 1 examined if cocaine administered immediately before or immediately after the behavioral session led to the development of tolerance to effects of cocaine during the behavioral session. The results showed that pre-session administration of cocaine reliably led to tolerance, and post-session administration of cocaine led to tolerance in half the subjects. Experiment 2 examined whether eating under effects of cocaine in the home cage, which occurs if the drug is given post-session, contributed to the development of tolerance to effects of cocaine on key pecking during the behavioral session. In this experiment, some subjects were administered cocaine after the behavioral session and immediately before being fed their post-session food ration, and other subjects were fed their post-session food ration immediately after the session and were administered cocaine one hour later. Results of Experiment 2 found that eating in the home cage under the effects of cocaine was not necessary for tolerance to develop to effects of cocaine during the behavioral session, and that the majority of subjects developed tolerance from post-session cocaine administration. Experiment 3 examined whether mere exposure to cocaine in the home cage without exposure to an experimental session led to tolerance to effects of cocaine during a behavioral session. Mere drug exposure did not reliably produce tolerance during the behavioral session. Experiment 4 examined if daily cocaine administration during dose-response curve redetermination was necessary for tolerance to develop. The results showed that tolerance from post-session cocaine administration was readily observed even when chronic dosing was discontinued during dose-response curve assessment. Therefore, the combined results showed that pigeons often develop tolerance to effects of cocaine during the behavioral session when cocaine is administered post-session. Some aspect of exposure to the experimental session or experimental context on a regular basis was necessary for tolerance to develop, yet this… Advisors/Committee Members: Branch, Marc N. (committee chair), Spector, Alan C. (committee member), Dallery, Jesse (committee member), Iwata, Brian (committee member), Brockmann, H. Jane Jane (committee member).

Subjects/Keywords: cocaine, operant, pigeon, tolerance; Psychology

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APA (6^th Edition):

Marusich, J. (2008). Pharmacological and Environmental Factors in the Development of Contingent Tolerance to Cocaine in Pigeons. (Doctoral Dissertation). University of Florida. Retrieved from http://ufdc.ufl.edu/UFE0022416

Chicago Manual of Style (16^th Edition):

Marusich, Julie. “Pharmacological and Environmental Factors in the Development of Contingent Tolerance to Cocaine in Pigeons.” 2008. Doctoral Dissertation, University of Florida. Accessed August 16, 2018. http://ufdc.ufl.edu/UFE0022416.

MLA Handbook (7^th Edition):

Marusich, Julie. “Pharmacological and Environmental Factors in the Development of Contingent Tolerance to Cocaine in Pigeons.” 2008. Web. 16 Aug 2018.

Vancouver:

Marusich J. Pharmacological and Environmental Factors in the Development of Contingent Tolerance to Cocaine in Pigeons. [Internet] [Doctoral dissertation]. University of Florida; 2008. [cited 2018 Aug 16]. Available from: http://ufdc.ufl.edu/UFE0022416.

Council of Science Editors:

Marusich J. Pharmacological and Environmental Factors in the Development of Contingent Tolerance to Cocaine in Pigeons. [Doctoral Dissertation]. University of Florida; 2008. Available from: http://ufdc.ufl.edu/UFE0022416

University of South Florida

15. Haire, Kambria. Elucidation of the Role of Poly(ADP-Ribose) Polymerase in Drug-Induced Toxicity.

Degree: 2015, University of South Florida

URL: http://scholarcommons.usf.edu/etd/5959

► Drug toxicity may cause liver injury, resulting in damage to cells and tissues. This damage can lead to cytotoxic events that may result in an… (more)

▼ Drug toxicity may cause liver injury, resulting in damage to cells and tissues. This damage can lead to cytotoxic events that may result in an activation of poly (ADP-ribose) polymerase (PARP). A study was conducted to determine if cocaine and acetaminophen toxicity lead to DNA damage and to the activation of the repair protein, PARP in the liver using the hepatotoxicants: cocaine and acetaminophen (APAP). A dose-response analysis for cocaine concluded that a dose as low as 20 mg/kg resulted in elevated ALT levels. A higher dose of 60 mg/kg was tested for analyses but resulted in severe hemorrhaging. The dose-response analyses for APAP resulted in no elevated liver enzyme levels for a 75 mg/kg and 150 mg/kg dose. A dose of 50 mg/kg for cocaine, and a dose of 300 mg/kg for APAP were used to analyze temporal trends for both toxicants. Both cocaine and APAP produced incremental increases in ALT at the 2 hour, 6 hour, 18 hour, and 24 hour time points, respectively. PARP activity analysis for cocaine measured the highest activity at the 2hr and 6hr time points. PARP analysis for acetaminophen measured gradual increases until the 18 hour time point where the highest level of PARP activity was measured. A PARP inhibition analysis was conducted with cocaine and (APAP) to understand the impact of a PARP inhibitor, 1,5-dihydroxyisoquinoline (DIQ), on PARP activity in the liver. A 50 mg/kg dose of cocaine or a 300 mg/kg dose of APAP was administered, followed by a 10 mg/kg dose of DIQ at 1) the time of initial toxicant dose (0 hour), or 2) 1 hour after initial toxicant dose (1hr). The PARP inhibition analysis for cocaine and APAP was conducted at 6 and 18 hours post initial dose, respectively, when the highest levels of PARP were observed. Inhibition analyses determined that ALT declined significantly when DIQ was administered immediately following the initial toxicant dose for both toxicants. DIQ administered 1 hr after initial toxicant dose resulted in slightly higher ALT than the 0 hr time point. Decreases in PARP activity were observed at the 0 hr time point, with slightly higher PARP levels observed at the 1 hr time point. Decreased PARP activity was observed following DIQ treatment with both, a concurrent drug treatment and treatment following drug administration. Cocaine and APAP treatment did not cause DNA fragmentation. A liver glutathione (GSH) analysis conducted for cocaine and APAP did not correlate with DIQ alteration of PARP activity. The mechanism of DIQ effects on drug-induced hepatotoxicity appears to be GSH independent. DIQ was effective in reducing drug-induced hepatotoxicity and preserving organ function.

Subjects/Keywords: PARP; Heptotoxicity; Cocaine; Acetaminophen; Toxicology

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APA (6^th Edition):

Haire, K. (2015). Elucidation of the Role of Poly(ADP-Ribose) Polymerase in Drug-Induced Toxicity. (Thesis). University of South Florida. Retrieved from http://scholarcommons.usf.edu/etd/5959

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Haire, Kambria. “Elucidation of the Role of Poly(ADP-Ribose) Polymerase in Drug-Induced Toxicity.” 2015. Thesis, University of South Florida. Accessed August 16, 2018. http://scholarcommons.usf.edu/etd/5959.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Haire, Kambria. “Elucidation of the Role of Poly(ADP-Ribose) Polymerase in Drug-Induced Toxicity.” 2015. Web. 16 Aug 2018.

Vancouver:

Haire K. Elucidation of the Role of Poly(ADP-Ribose) Polymerase in Drug-Induced Toxicity. [Internet] [Thesis]. University of South Florida; 2015. [cited 2018 Aug 16]. Available from: http://scholarcommons.usf.edu/etd/5959.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Haire K. Elucidation of the Role of Poly(ADP-Ribose) Polymerase in Drug-Induced Toxicity. [Thesis]. University of South Florida; 2015. Available from: http://scholarcommons.usf.edu/etd/5959

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas Tech University

16. Clark, Jonathon Cary. The effect of cocaine on murine peritoneal macrophages.

Degree: 1995, Texas Tech University

URL: http://hdl.handle.net/2346/18163

► In recent years, cocaine has had a resurgence in popularity in the United States (Adams and Durell, 1984; Katz, 1985). The increased use of cocaine… (more)

Subjects/Keywords: Macrophages; Cocaine

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APA (6^th Edition):

Clark, J. C. (1995). The effect of cocaine on murine peritoneal macrophages. (Masters Thesis). Texas Tech University. Retrieved from http://hdl.handle.net/2346/18163

Chicago Manual of Style (16^th Edition):

Clark, Jonathon Cary. “The effect of cocaine on murine peritoneal macrophages.” 1995. Masters Thesis, Texas Tech University. Accessed August 16, 2018. http://hdl.handle.net/2346/18163.

MLA Handbook (7^th Edition):

Clark, Jonathon Cary. “The effect of cocaine on murine peritoneal macrophages.” 1995. Web. 16 Aug 2018.

Vancouver:

Clark JC. The effect of cocaine on murine peritoneal macrophages. [Internet] [Masters thesis]. Texas Tech University; 1995. [cited 2018 Aug 16]. Available from: http://hdl.handle.net/2346/18163.

Council of Science Editors:

Clark JC. The effect of cocaine on murine peritoneal macrophages. [Masters Thesis]. Texas Tech University; 1995. Available from: http://hdl.handle.net/2346/18163

Texas Tech University

17. Brown, Deanna Jo. The effects of cocaine on viral replication in immune cells.

Degree: 1996, Texas Tech University

URL: http://hdl.handle.net/2346/14961

► Previous studies have shown that cocaine is capable of altering a number of macrophage functions. The present study demonstrates that the incubation of murine peritoneal… (more)

Subjects/Keywords: Cocaine; Macrophages

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APA (6^th Edition):

Brown, D. J. (1996). The effects of cocaine on viral replication in immune cells. (Masters Thesis). Texas Tech University. Retrieved from http://hdl.handle.net/2346/14961

Chicago Manual of Style (16^th Edition):

Brown, Deanna Jo. “The effects of cocaine on viral replication in immune cells.” 1996. Masters Thesis, Texas Tech University. Accessed August 16, 2018. http://hdl.handle.net/2346/14961.

MLA Handbook (7^th Edition):

Brown, Deanna Jo. “The effects of cocaine on viral replication in immune cells.” 1996. Web. 16 Aug 2018.

Vancouver:

Brown DJ. The effects of cocaine on viral replication in immune cells. [Internet] [Masters thesis]. Texas Tech University; 1996. [cited 2018 Aug 16]. Available from: http://hdl.handle.net/2346/14961.

Council of Science Editors:

Brown DJ. The effects of cocaine on viral replication in immune cells. [Masters Thesis]. Texas Tech University; 1996. Available from: http://hdl.handle.net/2346/14961

University of Texas Medical Branch – Galveston

18. [No author]. Dopamine-induced synaptic plasticity in the amygdala in saline-and cocaine-treated animals undergoing conditioned place preference .

Degree: 2008, University of Texas Medical Branch – Galveston

URL: http://hdl.handle.net/2152.3/295

► One of the biggest problems facing cocaine addicts is relapse and currently there are no treatments for relapse. These studies will provide insight into the… (more)

Subjects/Keywords: PLD; dopamine; cocaine addiction; amygdala

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APA (6^th Edition):

author], [. (2008). Dopamine-induced synaptic plasticity in the amygdala in saline-and cocaine-treated animals undergoing conditioned place preference . (Thesis). University of Texas Medical Branch – Galveston. Retrieved from http://hdl.handle.net/2152.3/295

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

author], [No. “Dopamine-induced synaptic plasticity in the amygdala in saline-and cocaine-treated animals undergoing conditioned place preference .” 2008. Thesis, University of Texas Medical Branch – Galveston. Accessed August 16, 2018. http://hdl.handle.net/2152.3/295.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

author], [No. “Dopamine-induced synaptic plasticity in the amygdala in saline-and cocaine-treated animals undergoing conditioned place preference .” 2008. Web. 16 Aug 2018.

Vancouver:

author] [. Dopamine-induced synaptic plasticity in the amygdala in saline-and cocaine-treated animals undergoing conditioned place preference . [Internet] [Thesis]. University of Texas Medical Branch – Galveston; 2008. [cited 2018 Aug 16]. Available from: http://hdl.handle.net/2152.3/295.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

author] [. Dopamine-induced synaptic plasticity in the amygdala in saline-and cocaine-treated animals undergoing conditioned place preference . [Thesis]. University of Texas Medical Branch – Galveston; 2008. Available from: http://hdl.handle.net/2152.3/295

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas A&M University

19. Valles, Rodrigo, Jr. Behavioral mechanisms underlying the extinction of cocaine self-administration.

Degree: 2006, Texas A&M University

URL: http://hdl.handle.net/1969.1/3105

► The aim of the present series of experiments was to outline the influence of different doses of cocaine during training, training schedule, training length and… (more)

▼ The aim of the present series of experiments was to outline the influence of different doses of cocaine during training, training schedule, training length and abstinence duration to modulate subsequent extinction and reinstatement patterns. Abram Amsel??s general theory of persistence were used to both design and explain various aspects of these models. For Experiment 1, rats self-administered cocaine (0.25, 0.50 or 1.00 mg/kg) intravenously and were then tested in an extinction preparation using saline infusions (5 days) and then only the stimulus light as the reinforcer (3 days). Experiment 2 examined schedules by magnitude interactions by training rats on two fixed-ratio (FR) schedules (FR-1 or FR-10 using either 0.25 or 1.00 mg/kg cocaine). Animals were tested in an extinction protocol (10 days; no stimulus light) and subsequently tested for reinstatement (1 day) that utilized presentations of the stimulus light. Experiment 3 addressed the effects of training length (15 or 30 days of training using either 0.25 or 1.00 mg/kg cocaine) using the same protocol as in Experiment 2. Experiment 4 examined the modulation potential of two abstinence lengths (15 or 30 days using either 0.25 or 0.50 mg/kg cocaine) using the same conditions as Experiment 2. Experiment 1 indicated the greatest resistance to extinction using the lowest training dose (0.25 mg/kg). The removal of saline caused an apparent extinction burst indicative of reward seeking. Experiment 2 showed that animals trained under partial reinforcement schedules persisted more during extinction. Furthermore, rats trained using 1.00 were more resistant than those trained with 0.25 mg/kg. Reinstatement of drug seeking was more pronounced in rats trained using an FR-10 schedule. Experiment 3 indicated greater resistance to extinction in rats trained for 15 versus 30 days. Rats trained on 0.50 mg/kg for 30 days showed less cue-induced reinstatement than those trained for 15 days. Experiment 4 showed increased resistance to extinction when rats were trained on 0.25 mg/kg and forced to abstain for 30 versus 15 days. Directionally opposite effects were apparent in groups trained with 0.50 mg/kg. Reinstatement data indicated greater responsivity to cues by animals abstaining for 30 versus 15 days. Advisors/Committee Members: Nation, Jack R (advisor), Bratton, Gerald R (committee member), Setlow, Barry (committee member), Wellman, Paul J (committee member).

Subjects/Keywords: Extinction; Cocaine

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APA (6^th Edition):

Valles, Rodrigo, J. (2006). Behavioral mechanisms underlying the extinction of cocaine self-administration. (Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/3105

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Valles, Rodrigo, Jr. “Behavioral mechanisms underlying the extinction of cocaine self-administration.” 2006. Thesis, Texas A&M University. Accessed August 16, 2018. http://hdl.handle.net/1969.1/3105.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Valles, Rodrigo, Jr. “Behavioral mechanisms underlying the extinction of cocaine self-administration.” 2006. Web. 16 Aug 2018.

Vancouver:

Valles, Rodrigo J. Behavioral mechanisms underlying the extinction of cocaine self-administration. [Internet] [Thesis]. Texas A&M University; 2006. [cited 2018 Aug 16]. Available from: http://hdl.handle.net/1969.1/3105.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Valles, Rodrigo J. Behavioral mechanisms underlying the extinction of cocaine self-administration. [Thesis]. Texas A&M University; 2006. Available from: http://hdl.handle.net/1969.1/3105

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Texas Southwestern Medical Center

20. Noonan, Michele Ann. The Role of Adult Neurogenesis in Cocaine Addiction.

Degree: 2009, University of Texas Southwestern Medical Center

URL: http://hdl.handle.net/2152.5/438

► New neurons are born in the adult hippocampus in a region known as the subgranular zone (SGZ). This process is dynamically regulated and new neurons… (more)

▼ New neurons are born in the adult hippocampus in a region known as the subgranular zone (SGZ). This process is dynamically regulated and new neurons are thought to be important for certain types of spatial learning and memory. Proliferation of SGZ neural progenitors is decreased by drugs of abuse, yet it is not clear how the type and amount of drug as well as the pattern of administration changes long-term effects on neurogenesis. In addition, it is unclear what role if any SGZ neurogenesis plays in initiating drug-taking or relapse behaviors, or whether changes in neurogenesis are merely side effects of drug-taking. I first examined effects of chronic cocaine self-administration and withdrawal on the different stages of neurogenesis. I found an early deficit in proliferation of neural progenitors, as well as a 4 week delayed increase in doublecortin-positive (DCX+) immature neurons which were common to both rats in withdrawal or those continuing to self-administer cocaine. I next asked the question of the functional consequence of changes in adult hippocampal neurogenesis to the acquisition and maintenance of drug-taking, as well as relapse to drug-taking. I found that reduced adult neurogenesis via cranial irradiation prior to cocaine-taking was associated with increased acquisition of drug-taking and increased motivation for cocaine, but not sucrose, while reduced adult neurogenesis after rats have acquired cocaine self-administration was associated with increased resistance to extinction of drug-seeking behavior. Finally, I asked if formation of drug-context associations would be altered in rodents with reduced neurogenesis in a passive drug exposure paradigm. I found that a transgenic mouse with reduced adult neurogenesis has impaired long-term drug-context memory in the cocaine conditioned place preference paradigm (CPP). Together these findings suggest that reduced adult hippocampal neurogenesis is a risk factor for drug addiction, that decreased proliferation after chronic drug intake likely contributes to drug-taking and drug-seeking behaviors, and that the delayed increase in immature neurons after drug-taking is likely protective against relapse. In sum, increases in adult hippocampal neurogenesis are beneficial both to the naïve and addicted brain, and therapeutics specifically increasing adult neurogenesis could aid in preventing initial addiction as well preventing future relapse. Advisors/Committee Members: Eisch, Amelia J..

Subjects/Keywords: Hippocampus; Cocaine-Related Disorders; Neurogenesis

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APA (6^th Edition):

Noonan, M. A. (2009). The Role of Adult Neurogenesis in Cocaine Addiction. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/438

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Noonan, Michele Ann. “The Role of Adult Neurogenesis in Cocaine Addiction.” 2009. Thesis, University of Texas Southwestern Medical Center. Accessed August 16, 2018. http://hdl.handle.net/2152.5/438.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Noonan, Michele Ann. “The Role of Adult Neurogenesis in Cocaine Addiction.” 2009. Web. 16 Aug 2018.

Vancouver:

Noonan MA. The Role of Adult Neurogenesis in Cocaine Addiction. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2009. [cited 2018 Aug 16]. Available from: http://hdl.handle.net/2152.5/438.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Noonan MA. The Role of Adult Neurogenesis in Cocaine Addiction. [Thesis]. University of Texas Southwestern Medical Center; 2009. Available from: http://hdl.handle.net/2152.5/438

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Texas Southwestern Medical Center

21. Jester, Bryan Elliott. Examining the Relationship Between Impulsive Personalities and Neural Functioning in Cocaine-Addicted Participants.

Degree: 2013, University of Texas Southwestern Medical Center

URL: http://hdl.handle.net/2152.5/1308

► BACKGROUND: Those who suffer from addiction are unable to discontinue use despite serious consequences affecting their social, professional, and family lives. Individuals who suffer from… (more)

▼ BACKGROUND: Those who suffer from addiction are unable to discontinue use despite serious consequences affecting their social, professional, and family lives. Individuals who suffer from the disorder often alienate themselves from loved ones and lose their jobs. Addiction involves continuing a behavior despite severe negative consequences. Numerous studies have identified a relationship between impulsivity and the development of substance abuse. This study examines the relationship of impulsive personality facets and neural functioning associated with inhibition. SUBJECTS: The study sample included 24 healthy control participants and 56 cocaine-addicted participants. Participants ranged in age from 25 to 54 years old with a mean age of 43.27 (±SD 7.84). The group was comprised of 68 male and 12 female participants, 28.7% self identified as Caucasian, 66.3% African American, 3.8% Hispanic, and 1.3% Asian/Other. Healthy controls and cocaine-addicted participants were similar in age and race but differed in gender (p= .02). The control group had 17 males and 7 females while the cocaine-addicted group had 51 males and 5 females. METHODS: Demographic information was gathered for all participants. Each participant also completed a Neuroticism Extroversion and Openness (NEO) personality measure and Temperament and Character Inventory (TCI), Structured Clinical Interview for DSM-IV (SCID), Wechsler Test of Adult Reading (WTAR). They then performed the stop signal task (SST) during functional magnetic resonance imaging (fMRI) to gather data on neural activation during Stop-Success (SS) and Stop-Failure (SF). fMRI data was analyzed using FSL imaging software. All statistics were run with SPSS software. Functional ROIs were identified and analyzed in fMRI Expert Analysis Tool query (FEATqueary) to gather data on each participantÕs change in blood oxygen level dependent (BOLD) activation during Stop-Success (SS) and Stop-Failure (SF). Impulsive personality facets were then used to identify relationships between BOLD activations of the ROIs. RESULTS: Between group comparisons found significant differences in mean scores on all of the impulsive personality facets except for Exploratory Excitability and Persistence from the TCI, and Excitement Seeking from the NEO. Neuroimaging results are similar to other studies utilizing the SST finding changes in activation of the middle frontal gyrus, superior frontal gyrus, cingulate gyrus, medial frontal gyrus, insula, caudate and supramarginal gyrus during Stop-Failure; and superior parietal lobule, middle frontal gyrus, precuneus, supramarginal gyrus, inferior temporal gyrus, and middle occipital gyrus during Stop-Success. However, no differences in BOLD activation between groups were observed. Numerous relationships were identified between the personality facets and BOLD activation of the regions of interest (ROIs). To further elucidate this relationship between neural functioning and personality a principal component analysis (PCA) was conducted on all eleven personality facets. The… Advisors/Committee Members: Adinoff, Bryon H., North, Carol S., Spence, Jeffrey.

Subjects/Keywords: Impulsive Behavior; Cocaine-Related Disorders

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APA (6^th Edition):

Jester, B. E. (2013). Examining the Relationship Between Impulsive Personalities and Neural Functioning in Cocaine-Addicted Participants. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/1308

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jester, Bryan Elliott. “Examining the Relationship Between Impulsive Personalities and Neural Functioning in Cocaine-Addicted Participants.” 2013. Thesis, University of Texas Southwestern Medical Center. Accessed August 16, 2018. http://hdl.handle.net/2152.5/1308.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jester, Bryan Elliott. “Examining the Relationship Between Impulsive Personalities and Neural Functioning in Cocaine-Addicted Participants.” 2013. Web. 16 Aug 2018.

Vancouver:

Jester BE. Examining the Relationship Between Impulsive Personalities and Neural Functioning in Cocaine-Addicted Participants. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2013. [cited 2018 Aug 16]. Available from: http://hdl.handle.net/2152.5/1308.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jester BE. Examining the Relationship Between Impulsive Personalities and Neural Functioning in Cocaine-Addicted Participants. [Thesis]. University of Texas Southwestern Medical Center; 2013. Available from: http://hdl.handle.net/2152.5/1308

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Boston University

22. Culp, Jenna L. Cocaine use, treatment retention and opioid abstinence at six months in a coordinated primary care and substance abuse treatment clinic among opioid-dependent patients treated with buprenorphine.

Degree: MA, Medical Sciences, 2012, Boston University

URL: http://hdl.handle.net/2144/12336

► Cocaine use among opioid dependent persons is common, with an estimated 40 to 70% of those seeking treatment for opioid dependence, also using cocaine (Sullivan… (more)

▼ Cocaine use among opioid dependent persons is common, with an estimated 40 to 70% of those seeking treatment for opioid dependence, also using cocaine (Sullivan et al., 2011 ). The effects of cocaine use on treatment outcomes for those seeking medication assisted treatment (MAT) for opioid dependence are not well understood. Buprenorphine, prescribed under the brand name Suboxone, has recently emerged as a convenient, effective method of MAT. The Facilitated Access to Substance Abuse Treatment with Prevention And Treatment of HIV (FAST PATH) program at Boston Medical Center, is a research study to provide substance abuse treatment along with primary care and HIV risk-reduction counseling to those afflicted with these epidemics. The objective of this study was to determine the association of cocaine use with treatment retention and opioid abstinence at six months for patients receiving buprenorphine in the FAST PATH program. A prospective cohort study was conducted on 116 patients enrolled in the FAST PATH program through 02/01/2012. Assessments were conducted at baseline and six months to evaluate the association between baseline cocaine use and treatment retention as well as opioid abstinence at six months. Baseline cocaine use was measured by either any urine toxicology screen positive for cocaine prior to study enrollment or 30 day self-reported cocaine use on the initial assessment. Of the 116 participants, 39% were positive for cocaine use at baseline and 52% were HIV positive. Baseline cocaine use had no effect significant on treatment retention or opioid abstinence at six months. Among all the participant characteristics measured, there were no significant differences between the cocaine positive (n=45) and cocaine negative (n=71) groups. In adjusted analysis, age was the only covariate which was significant at predicting the odds of treatment retention or opioid abstinence with a 1.11 (p-value = 0.0003) and 1.08 (p-value = 0.02) greater odds of each, respectively. Although cocaine use did not affect the dependent variables, integrated substance abuse and primary care clinics utilizing buprenorphine are a rich area of future research. Specifically, subsequent studies should determine how varied groups of opioid dependent persons perform within this framework, and the underlying characteristics moderating their outcomes.

Subjects/Keywords: Opioid dependence; Cocaine; FAST PATH

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Culp, J. L. (2012). Cocaine use, treatment retention and opioid abstinence at six months in a coordinated primary care and substance abuse treatment clinic among opioid-dependent patients treated with buprenorphine. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/12336

Chicago Manual of Style (16^th Edition):

Culp, Jenna L. “Cocaine use, treatment retention and opioid abstinence at six months in a coordinated primary care and substance abuse treatment clinic among opioid-dependent patients treated with buprenorphine.” 2012. Masters Thesis, Boston University. Accessed August 16, 2018. http://hdl.handle.net/2144/12336.

MLA Handbook (7^th Edition):

Culp, Jenna L. “Cocaine use, treatment retention and opioid abstinence at six months in a coordinated primary care and substance abuse treatment clinic among opioid-dependent patients treated with buprenorphine.” 2012. Web. 16 Aug 2018.

Vancouver:

Culp JL. Cocaine use, treatment retention and opioid abstinence at six months in a coordinated primary care and substance abuse treatment clinic among opioid-dependent patients treated with buprenorphine. [Internet] [Masters thesis]. Boston University; 2012. [cited 2018 Aug 16]. Available from: http://hdl.handle.net/2144/12336.

Council of Science Editors:

Culp JL. Cocaine use, treatment retention and opioid abstinence at six months in a coordinated primary care and substance abuse treatment clinic among opioid-dependent patients treated with buprenorphine. [Masters Thesis]. Boston University; 2012. Available from: http://hdl.handle.net/2144/12336

Georgia Tech

23. Javanmard, Sahar. Synthesis and pharmacology of site-specific cocaine abuse treatment agents.

Degree: PhD, Chemistry, 2002, Georgia Tech

URL: http://hdl.handle.net/1853/30952

Subjects/Keywords: Cocaine habit Treatment; Cocaine Toxicology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Javanmard, S. (2002). Synthesis and pharmacology of site-specific cocaine abuse treatment agents. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/30952

Chicago Manual of Style (16^th Edition):

Javanmard, Sahar. “Synthesis and pharmacology of site-specific cocaine abuse treatment agents.” 2002. Doctoral Dissertation, Georgia Tech. Accessed August 16, 2018. http://hdl.handle.net/1853/30952.

MLA Handbook (7^th Edition):

Javanmard, Sahar. “Synthesis and pharmacology of site-specific cocaine abuse treatment agents.” 2002. Web. 16 Aug 2018.

Vancouver:

Javanmard S. Synthesis and pharmacology of site-specific cocaine abuse treatment agents. [Internet] [Doctoral dissertation]. Georgia Tech; 2002. [cited 2018 Aug 16]. Available from: http://hdl.handle.net/1853/30952.

Council of Science Editors:

Javanmard S. Synthesis and pharmacology of site-specific cocaine abuse treatment agents. [Doctoral Dissertation]. Georgia Tech; 2002. Available from: http://hdl.handle.net/1853/30952

Nelson Mandela Metropolitan University

24. Plumb, Sarah. The art of addiction : a phenomenological study of the lived experiences of cocaine dependents.

Degree: Faculty of Health Sciences, 2009, Nelson Mandela Metropolitan University

URL: http://hdl.handle.net/10948/902

► Addiction is a complex social phenomenon resulting from psychological and physiological dependence. The aim of the study was to create a clinical impression of the… (more)

Subjects/Keywords: Cocaine abuse; Cocaine – Social aspects; Drugs – Physiological effect

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APA (6^th Edition):

Plumb, S. (2009). The art of addiction : a phenomenological study of the lived experiences of cocaine dependents. (Thesis). Nelson Mandela Metropolitan University. Retrieved from http://hdl.handle.net/10948/902

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Plumb, Sarah. “The art of addiction : a phenomenological study of the lived experiences of cocaine dependents.” 2009. Thesis, Nelson Mandela Metropolitan University. Accessed August 16, 2018. http://hdl.handle.net/10948/902.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Plumb, Sarah. “The art of addiction : a phenomenological study of the lived experiences of cocaine dependents.” 2009. Web. 16 Aug 2018.

Vancouver:

Plumb S. The art of addiction : a phenomenological study of the lived experiences of cocaine dependents. [Internet] [Thesis]. Nelson Mandela Metropolitan University; 2009. [cited 2018 Aug 16]. Available from: http://hdl.handle.net/10948/902.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Plumb S. The art of addiction : a phenomenological study of the lived experiences of cocaine dependents. [Thesis]. Nelson Mandela Metropolitan University; 2009. Available from: http://hdl.handle.net/10948/902

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Texas Southwestern Medical Center

25. Carreira Franceschi, Maria Beatriz. Characterization of Histone Deacetylase 4 and Histone Deacetylase 5 in Cocaine-Related Behaviors.

Degree: 2016, University of Texas Southwestern Medical Center

URL: http://hdl.handle.net/2152.5/5304

► In recent years a focus on epigenetic mechanisms as mediators of cocaine-related behavioral, structural and functional plasticity has developed. One family of epigenetic molecules that… (more)

▼ In recent years a focus on epigenetic mechanisms as mediators of cocaine-related behavioral, structural and functional plasticity has developed. One family of epigenetic molecules that may underlie cocaine behavioral and functional changes is the histone deacetylase family that acts to mediate transcriptional repression. The class IIa subgroup of histone deacetylases is poised as an intracellular signal detector and effector by virtue of their ability to shuttle subcellularly in a dynamic and activity-dependent manner primarily driven by phosphorylation status of the protein at multiple residues. The overlying goal of this thesis was to two-faceted: to characterize the regulation of two class IIa members, HDAC4 and HDAC5, by cocaine-mediated signaling and to characterize the role of HDAC4 and HDAC5 in cocaine-associated behavioral plasticity. We report the regulation of phosphorylation and localization of HDAC4 and HDAC5 is in opposition. HDAC5 is dephosphorylated and accumulated in the nuclear compartment in response to cocaine, dopamine dependent signaling and cAMP activity. Meanwhile, we observe that HDAC4 is weakly dephosphorylated by cAMP activity in culture but weakly phosphorylated in vivo. These findings encouraged the analysis of function of these highly homologous class members. We assessed the function of HDAC4 and HDAC5 in the nucleus accumbens, a critical region for reward, by over-expressing wildtype and nuclear variants by targeted viral-mediated gene transfer. We report an attenuation of cocaine reward learning by nuclear HDAC5 but not wildtype or HDAC4 over-expression. We further analyzed the role of HDAC5 in self-administration behavior and report an effect of nuclear HDAC5, but not wildtype, on models of reinstatement of seeking, a preclinical model of relapse. These effects were observed in the absence of an effect on intake, sensitivity or motivation to self-administer. Because HDAC4 and HDAC5 bind nuclear transcriptional regulators to exert transcriptional repression of target genes we analyzed the dependence of nuclear HDAC5 on interacting with MEF2, a primary binding partners, and report that this interaction is likely required for modulating reinstatement of seeking but dispensable for cocaine reward. Taken together, these findings highlight the role of nuclear HDAC5 but not HDAC4 to limit cocaine reward and aspects of cocaine addiction-like behavior. Advisors/Committee Members: Self, David W., Cowan, Christopher W., Huber, Kimberly M., Rothenfluh, Adrian.

Subjects/Keywords: Cocaine; Cocaine-Related Disorders; Histone Deacetylases; Nucleus Accumbens; Reward; Self Administration

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APA (6^th Edition):

Carreira Franceschi, M. B. (2016). Characterization of Histone Deacetylase 4 and Histone Deacetylase 5 in Cocaine-Related Behaviors. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/5304

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Carreira Franceschi, Maria Beatriz. “Characterization of Histone Deacetylase 4 and Histone Deacetylase 5 in Cocaine-Related Behaviors.” 2016. Thesis, University of Texas Southwestern Medical Center. Accessed August 16, 2018. http://hdl.handle.net/2152.5/5304.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Carreira Franceschi, Maria Beatriz. “Characterization of Histone Deacetylase 4 and Histone Deacetylase 5 in Cocaine-Related Behaviors.” 2016. Web. 16 Aug 2018.

Vancouver:

Carreira Franceschi MB. Characterization of Histone Deacetylase 4 and Histone Deacetylase 5 in Cocaine-Related Behaviors. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2016. [cited 2018 Aug 16]. Available from: http://hdl.handle.net/2152.5/5304.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Carreira Franceschi MB. Characterization of Histone Deacetylase 4 and Histone Deacetylase 5 in Cocaine-Related Behaviors. [Thesis]. University of Texas Southwestern Medical Center; 2016. Available from: http://hdl.handle.net/2152.5/5304

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Kentucky

26. Smith, Christine Elizabeth. SPLENDOR IN THE BLUEGRASS: THE POLICING OF DRUG RELATED CRIME IN LEXINGTON, KENTUCKY.

Degree: 2010, University of Kentucky

URL: http://uknowledge.uky.edu/gradschool_theses/12

► This project is designed as a case study investigating the relationship and practices between residents and police officers in the William Wells Brown neighborhood of… (more)

Subjects/Keywords: Policing; community; crack cocaine; governmentality; splendor; Geography

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APA (6^th Edition):

Smith, C. E. (2010). SPLENDOR IN THE BLUEGRASS: THE POLICING OF DRUG RELATED CRIME IN LEXINGTON, KENTUCKY. (Masters Thesis). University of Kentucky. Retrieved from http://uknowledge.uky.edu/gradschool_theses/12

Chicago Manual of Style (16^th Edition):

Smith, Christine Elizabeth. “SPLENDOR IN THE BLUEGRASS: THE POLICING OF DRUG RELATED CRIME IN LEXINGTON, KENTUCKY.” 2010. Masters Thesis, University of Kentucky. Accessed August 16, 2018. http://uknowledge.uky.edu/gradschool_theses/12.

MLA Handbook (7^th Edition):

Smith, Christine Elizabeth. “SPLENDOR IN THE BLUEGRASS: THE POLICING OF DRUG RELATED CRIME IN LEXINGTON, KENTUCKY.” 2010. Web. 16 Aug 2018.

Vancouver:

Smith CE. SPLENDOR IN THE BLUEGRASS: THE POLICING OF DRUG RELATED CRIME IN LEXINGTON, KENTUCKY. [Internet] [Masters thesis]. University of Kentucky; 2010. [cited 2018 Aug 16]. Available from: http://uknowledge.uky.edu/gradschool_theses/12.

Council of Science Editors:

Smith CE. SPLENDOR IN THE BLUEGRASS: THE POLICING OF DRUG RELATED CRIME IN LEXINGTON, KENTUCKY. [Masters Thesis]. University of Kentucky; 2010. Available from: http://uknowledge.uky.edu/gradschool_theses/12

Temple University

27. Lamarre, Neil Stanley. Utilizing novel dose equivalence methodologies to examine cocaine's effects on the vasculature.

Degree: PhD, 2013, Temple University

URL: http://digital.library.temple.edu/u?/p245801coll10,221180

►

Pharmacology

UTILIZING NOVEL DOSE EQUIVALENCE METHODOLOGIES TO EXAMINE COCAINE'S EFFECTS ON THE VASCULATURE Neil S. Lamarre Doctor of Philosophy Temple University School of Medicine, 2013… (more)

▼

Pharmacology

UTILIZING NOVEL DOSE EQUIVALENCE METHODOLOGIES TO EXAMINE COCAINE'S EFFECTS ON THE VASCULATURE Neil S. Lamarre Doctor of Philosophy Temple University School of Medicine, 2013 Doctoral Advisory Committee Chair: Ronald J. Tallarida, Ph.D. Cocaine abuse and addiction is a serious health problem, resulting in thousands of emergency room visits and deaths each year in the United States. It is particularly toxic to the cardiovascular system, including deleterious effects on the peripheral vasculature. These effects are not well understood, but evidence suggests chronic cocaine use may lead to endothelial dysfunction, thereby increasing relative risk of a number of other cardiovascular diseases including stroke, aneurysm, myocardial infarction, hypertension, etc. Data from our lab, and others, suggest that the presence of a functional endothelium has a dramatic effect on the contractility of the rat aorta that is agonist-specific. Attenuation of this endothelium-dependent vasodilatory component of agonist action is a primary feature of endothelial dysfunction. We have utilized dose equivalence theory to calculate the dose response relationship for the endothelium-dependent vasodilatory component of an agonist causing overt vasoconstriction. This component cannot be measured directly, but our novel methodology allows us to quantitate agonist-specific impairment of vasodilation, and describe it using the familiar parameters of the dose response curve. Another strength of this method, relative to currently used in vitro methods, is that it also avoids the confounding variable of a second agonist used to produce the initial vasoconstriction. To validate the methodology, a pilot study was performed examining the endothelial dysfunction in STZ-induced diabetic rats, as a positive control for endothelial dysfunction. Interestingly, this treatment showed impairment in the endothelium-dependent vasodilatory component of action of norepinephrine, but not of angiotensin-II. Thus, our initial hypothesis was confirmed - that disruption of the vasodilatory components of various agonists are independent, and that agonist-specific information may prove useful. Next, we employed our new methodology utilizing the rat aorta as our vascular model to test the hypothesis that chronic cocaine administration causes endothelial dysfunction. We first examined the endothelium-dependent vasodilation component of a number of physiologically important vasoconstrictors, and attempted to determine which vasodilatory mediators contributed to the effect. We found the endothelium to have a profound effect on the dose response curve to three important endogenous agonists. These data suggest that under conditions of endothelial dysfunction exaggerated vasoconstriction could occur, even within normal plasma concentration ranges of these vasoconstrictors, resulting in elevated blood pressure and further damage to the endothelium over time. No endothelial dysfunction was observed with this treatment paradigm, using our methodology or the standard…

Advisors/Committee Members: Tallarida, Ronald J.;, Ruggieri, Michael R., Heckman, James L., Parry, Tom Jay, Raffa, Robert B., McGonigle, Paul;.

Subjects/Keywords: Pharmacology;

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lamarre, N. S. (2013). Utilizing novel dose equivalence methodologies to examine cocaine's effects on the vasculature. (Doctoral Dissertation). Temple University. Retrieved from http://digital.library.temple.edu/u?/p245801coll10,221180

Chicago Manual of Style (16^th Edition):

Lamarre, Neil Stanley. “Utilizing novel dose equivalence methodologies to examine cocaine's effects on the vasculature.” 2013. Doctoral Dissertation, Temple University. Accessed August 16, 2018. http://digital.library.temple.edu/u?/p245801coll10,221180.

MLA Handbook (7^th Edition):

Lamarre, Neil Stanley. “Utilizing novel dose equivalence methodologies to examine cocaine's effects on the vasculature.” 2013. Web. 16 Aug 2018.

Vancouver:

Lamarre NS. Utilizing novel dose equivalence methodologies to examine cocaine's effects on the vasculature. [Internet] [Doctoral dissertation]. Temple University; 2013. [cited 2018 Aug 16]. Available from: http://digital.library.temple.edu/u?/p245801coll10,221180.

Council of Science Editors:

Lamarre NS. Utilizing novel dose equivalence methodologies to examine cocaine's effects on the vasculature. [Doctoral Dissertation]. Temple University; 2013. Available from: http://digital.library.temple.edu/u?/p245801coll10,221180

Temple University

28. Kim, Jae Kyun. CXCL12/CXCR4 signaling in mesocorticolimbic reward pathways: relevance to cocaine reinforcement and relapse.

Degree: PhD, 2016, Temple University

URL: http://digital.library.temple.edu/u?/p245801coll10,399036

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Pharmacology

The role of chemokines as chemotactic cytokines and their functions in the immune system and related pathologies are well defined. Recently, strong evidence supporting… (more)

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Pharmacology

The role of chemokines as chemotactic cytokines and their functions in the immune system and related pathologies are well defined. Recently, strong evidence supporting the hypothesis that chemokines can act as modulators of neuronal activity and influence neurotransmission has been reported. The chemokine CXCL12 is constitutively expressed in adult brain and expression of CXCL12 and its cognate receptor CXCR4 have been reported in regions of rat brain that construct dopamine (DA) and glutamate (GLU) pathways such as ventral tegmental area (VTA), substantia nigra (SN), and nucleus accumbens (NAc). In the central nervous system (CNS), activation of CXCR4 on dopaminergic neurons and astrocytes initiate cascade of events that leads to DA and GLU release and influence synaptic transmission. In vivo, intracerebroventricular (ICV) CXCL12 has been shown to potentiate cocaine-induced locomotor activity. Based on these evidences, the studies, as outlined in this dissertation, aimed to expand understanding of how CXCL12/CXCR4 interaction can affect cocaine-induced behavior and reinforcement, with special focus on mechanisms involving GLU. We first evaluated involvement of CXCR4 activation by CXCL12 on cocaine-induced locomotor activity using a selective CXCR4 antagonist AMD3100. Results demonstrated that AMD3100 (5, 10 mg/kg, IP) pretreatment dose-dependently attenuated cocaine-induced locomotor activity without affecting the baseline activity. Thereafter, effects of AMD3100 on cocaine’s reinforcing efficacy were tested using a biased conditioned place preference (CPP) paradigm. In all CPP experiments, saline pretreated controls established a significant preference for the cocaine-paired context following four pairings with cocaine (10 mg/kg, IP). Rats pretreated with 2.5 and 5 mg/kg AMD3100 prior to each pairing session showed significantly lower preference for the cocaine-paired side, whereas rats pretreated with 1 mg/kg AMD3100 showed similar preference for the cocaine-paired side as the saline controls when tested in the absence of the drug. Rats pretreated with AMD3100 (5 mg/kg, IP) just once prior to testing showed significantly lower preference for the cocaine-paired side. These results demonstrate that CXCR4 antagonism reduces development and expression of cocaine-induced CPP. Intravenous cocaine self-administration (SA) was performed to examine the effects of AMD3100 on the acquisition of cocaine-taking behavior and reinstatement to cocaine-seeking. Acquisition of cocaine SA was studied using three doses of cocaine (0.375, 0.5, 0.75 mg/kg/infusion) on a fixed-ratio 1 (FR-1) schedule of reinforcement. Two doses of AMD3100 (5, 10 mg/kg, IP) were tested. In all SA experiments, saline pretreated controls readily acquired cocaine self-administration. The lower and higher AMD3100 decreased the number of reinforcers earned during the two hour sessions compared to saline controls when tested against acquisition of 0.375 and 0.5 mg/kg/infusion cocaine. However, when tested against the 0.75 mg/kg/infusion…

Advisors/Committee Members: Rawls, Scott M;, Ashby, Barrie, Unterwald, Ellen M, Eisenstein, Toby K, Ramirez, Servio H, Walker, Ellen A;.

Subjects/Keywords: Pharmacology;

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kim, J. K. (2016). CXCL12/CXCR4 signaling in mesocorticolimbic reward pathways: relevance to cocaine reinforcement and relapse. (Doctoral Dissertation). Temple University. Retrieved from http://digital.library.temple.edu/u?/p245801coll10,399036

Chicago Manual of Style (16^th Edition):

Kim, Jae Kyun. “CXCL12/CXCR4 signaling in mesocorticolimbic reward pathways: relevance to cocaine reinforcement and relapse.” 2016. Doctoral Dissertation, Temple University. Accessed August 16, 2018. http://digital.library.temple.edu/u?/p245801coll10,399036.

MLA Handbook (7^th Edition):

Kim, Jae Kyun. “CXCL12/CXCR4 signaling in mesocorticolimbic reward pathways: relevance to cocaine reinforcement and relapse.” 2016. Web. 16 Aug 2018.

Vancouver:

Kim JK. CXCL12/CXCR4 signaling in mesocorticolimbic reward pathways: relevance to cocaine reinforcement and relapse. [Internet] [Doctoral dissertation]. Temple University; 2016. [cited 2018 Aug 16]. Available from: http://digital.library.temple.edu/u?/p245801coll10,399036.

Council of Science Editors:

Kim JK. CXCL12/CXCR4 signaling in mesocorticolimbic reward pathways: relevance to cocaine reinforcement and relapse. [Doctoral Dissertation]. Temple University; 2016. Available from: http://digital.library.temple.edu/u?/p245801coll10,399036

University of Florida

29. Mitchell, Marci R. Adolescent Risk Taking, Dopamine Signaling, and Cocaine Self-Administration a Vicious Cycle.

Degree: Medical Sciences
Neuroscience (IDP), 2012, University of Florida

URL: http://ufdc.ufl.edu/UFE0044476

► In adolescence, poor decision making, risk taking, and druguse have been strongly linked; however the causal relationships among thesefactors are poorly understood. As causality is… (more)

▼ In adolescence, poor decision making, risk taking, and druguse have been strongly linked; however the causal relationships among thesefactors are poorly understood. As causality is difficult to disentangle inhumans, an animal model of risk taking was used to investigate causalrelationships between adolescent risk taking and cocaine self-administration inrats. Specifically, a Risky Decision-making Task (RDT) that was developed inour laboratory was used to investigate whether risky decision-making is apre-existing condition which may predict the propensity for drug use, and/or ifelevated risk taking is a result of drug use itself. In addition, the RDT wasused to determine if the relationships between risky decision-making aremodulated by dopaminergic signaling in the prefrontal cortex and striatum, as thesebrain regions have been heavily implicated in mediating both risky decision-makingand drug use. Findings from the experiments indicated that individualvariability in RDT performance during adolescence significantly predictedcocaine intake (i.e., greater risk taking was associated with greater cocaineintake) and that cocaine self-administrationrats exhibited greater risk taking compared to controlseven after 6 weeks of abstinence. Moreover, lower striatal D1 and D2 receptorexpression was associated with greater adolescent risk taking, and activationof D2 receptors in the ventral, but not dorsal, striatum biased choice behaviortoward a more risk averse pattern. These data indicatethat adolescent risk taking predicts acquisition of cocaineself-administration, and that cocaine self-administration can causelong-lasting elevations in risk taking. The findings that lower dopaminereceptor expression in striatum was associated with elevated risk taking andthat activation of dopamine (especially D2) receptors in the ventral striatumbiased choice behavior in the RDT toward greater risk aversion strongly suggestthat D2 receptors play a causal role in both risk taking behavior and cocaineuse. Together these findings provide support for a “vicious cycle” between risktaking and cocaine use which may be regulated by D2 receptors and mightcontribute to addictive processes. ( en ) Advisors/Committee Members: Setlow, Barry (committee chair), Bizon, Jennifer L. (committee member), Morgan, Drake (committee member), Nixon, Sara Jo (committee member), Dallery, Jesse (committee member).

Subjects/Keywords: adolescent – cocaine – risk-taking; Neuroscience (IDP)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mitchell, M. R. (2012). Adolescent Risk Taking, Dopamine Signaling, and Cocaine Self-Administration a Vicious Cycle. (Doctoral Dissertation). University of Florida. Retrieved from http://ufdc.ufl.edu/UFE0044476

Chicago Manual of Style (16^th Edition):

Mitchell, Marci R. “Adolescent Risk Taking, Dopamine Signaling, and Cocaine Self-Administration a Vicious Cycle.” 2012. Doctoral Dissertation, University of Florida. Accessed August 16, 2018. http://ufdc.ufl.edu/UFE0044476.

MLA Handbook (7^th Edition):

Mitchell, Marci R. “Adolescent Risk Taking, Dopamine Signaling, and Cocaine Self-Administration a Vicious Cycle.” 2012. Web. 16 Aug 2018.

Vancouver:

Mitchell MR. Adolescent Risk Taking, Dopamine Signaling, and Cocaine Self-Administration a Vicious Cycle. [Internet] [Doctoral dissertation]. University of Florida; 2012. [cited 2018 Aug 16]. Available from: http://ufdc.ufl.edu/UFE0044476.

Council of Science Editors:

Mitchell MR. Adolescent Risk Taking, Dopamine Signaling, and Cocaine Self-Administration a Vicious Cycle. [Doctoral Dissertation]. University of Florida; 2012. Available from: http://ufdc.ufl.edu/UFE0044476

University of Florida

30. Mccann, Sarah. Latent Growth Curve Analyses of the Development of Executive Functions in a Prospective, Longitudinal Cohort of Children with Prenatal Cocaine Exposure.

Degree: Psychology
Clinical and Health Psychology, 2010, University of Florida

URL: http://ufdc.ufl.edu/UFE0041899

► Animal studies demonstrate prenatal exposure to cocaine causes disruption of the neurotrophic roles of monoaminergic transmitters during early development, which, in turn, affects the cortical… (more)

▼ Animal studies demonstrate prenatal exposure to cocaine causes disruption of the neurotrophic roles of monoaminergic transmitters during early development, which, in turn, affects the cortical neuronal development of specific brain regions, including prefrontal cortex. In humans, this brain area is implicated in executive function (EF), a set of cognitive processes that are posited to subserve goal-directed behavior. Significant differences in EF between children with prenatal cocaine exposure (PCE) and well-matched comparison groups have not been consistently found. Within a longitudinal context, there have been no studies investigating the potential effect of PCE on the developmental trajectory of EF. Participants were children of pregnant women who were prospectively enrolled at birth in a longitudinal study of the developmental effects of PCE. At study enrollment, which generally occurred during pregnancy, cocaine-using mothers were matched to non-cocaine using mothers on race, socioeconomic status, parity and location of prenatal care. Both groups were predominately poor and African American and did not differ by child sex. At birth, PCE group had higher levels of other prenatal drug exposures (alcohol, tobacco, and marijuana), shorter gestational ages, and smaller head circumferences. Measures of EF (inhibition, working memory, and shifting) were obtained by blinded examiners when the children were ages 7, 10one half, and 12one half years. There were no group differences between the PCE children (n = 120) and non-exposed children (n = 116) with regard to cross-sectional performance on measures of EF at any time point. Univariate latent growth models were used to investigate the effect of amount of PCE as well as pre- and post-natal characteristics of the child and the environment (i.e., birth head circumference, gender, quality of the caregiving environment) on the developmental trajectory of inhibition, working memory, and shifting. Results indicated no direct effect of PCE on the initial performance or the development of EF over time. Smaller birth head circumference negatively predicted the inhibitory and working memory skills at age 7 as well as worse development of inhibitory skills over time. Additionally, a better quality home environment positively predicted working memory ability at age 7 years, though the home environment did not predict the developmental trajectory of any EF over time. ( en ) Advisors/Committee Members: Heaton, Shelley C. (committee chair), Johnson, James H. (committee member), Fennell, Eileen B. (committee member), Eyler, Fonda D. (committee member).

Subjects/Keywords: cocaine, cognition, development; Clinical and Health Psychology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mccann, S. (2010). Latent Growth Curve Analyses of the Development of Executive Functions in a Prospective, Longitudinal Cohort of Children with Prenatal Cocaine Exposure. (Doctoral Dissertation). University of Florida. Retrieved from http://ufdc.ufl.edu/UFE0041899

Chicago Manual of Style (16^th Edition):

Mccann, Sarah. “Latent Growth Curve Analyses of the Development of Executive Functions in a Prospective, Longitudinal Cohort of Children with Prenatal Cocaine Exposure.” 2010. Doctoral Dissertation, University of Florida. Accessed August 16, 2018. http://ufdc.ufl.edu/UFE0041899.

MLA Handbook (7^th Edition):

Mccann, Sarah. “Latent Growth Curve Analyses of the Development of Executive Functions in a Prospective, Longitudinal Cohort of Children with Prenatal Cocaine Exposure.” 2010. Web. 16 Aug 2018.

Vancouver:

Mccann S. Latent Growth Curve Analyses of the Development of Executive Functions in a Prospective, Longitudinal Cohort of Children with Prenatal Cocaine Exposure. [Internet] [Doctoral dissertation]. University of Florida; 2010. [cited 2018 Aug 16]. Available from: http://ufdc.ufl.edu/UFE0041899.

Council of Science Editors:

Mccann S. Latent Growth Curve Analyses of the Development of Executive Functions in a Prospective, Longitudinal Cohort of Children with Prenatal Cocaine Exposure. [Doctoral Dissertation]. University of Florida; 2010. Available from: http://ufdc.ufl.edu/UFE0041899

Open Access Theses and Dissertations