subject:(cocaine)

1. Kromrey, Sarah Allyson. Endogenous hormonal milieu of female cynomolgus monkeys: interaction with cognitive performance, social rank and acquisition of cocaine self-administration.

Degree: 2015, Wake Forest University

URL: http://hdl.handle.net/10339/57103

► There are currently no FDA-approved drug treatments for cocaine abuse. The use of female subjects and a better understanding of the influence of hormones and… (more)

Subjects/Keywords: cocaine

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APA (6^th Edition):

Kromrey, S. A. (2015). Endogenous hormonal milieu of female cynomolgus monkeys: interaction with cognitive performance, social rank and acquisition of cocaine self-administration. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/57103

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kromrey, Sarah Allyson. “Endogenous hormonal milieu of female cynomolgus monkeys: interaction with cognitive performance, social rank and acquisition of cocaine self-administration.” 2015. Thesis, Wake Forest University. Accessed April 11, 2021. http://hdl.handle.net/10339/57103.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kromrey, Sarah Allyson. “Endogenous hormonal milieu of female cynomolgus monkeys: interaction with cognitive performance, social rank and acquisition of cocaine self-administration.” 2015. Web. 11 Apr 2021.

Vancouver:

Kromrey SA. Endogenous hormonal milieu of female cynomolgus monkeys: interaction with cognitive performance, social rank and acquisition of cocaine self-administration. [Internet] [Thesis]. Wake Forest University; 2015. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/10339/57103.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kromrey SA. Endogenous hormonal milieu of female cynomolgus monkeys: interaction with cognitive performance, social rank and acquisition of cocaine self-administration. [Thesis]. Wake Forest University; 2015. Available from: http://hdl.handle.net/10339/57103

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Utah

2. Riedy, Matthew D. Reinstatement of Cocaine-Seeking Behavior Induced by Discrete Sensory Cues and the Associated Immediate Early Gene Expression.

Degree: PhD, Neurosurgery;, 2010, University of Utah

URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/442/rec/969

► Drug addiction is a serious problem for modern societies worldwide. There are remarkable costs associated with this problem, from the direct costs of the substance… (more)

▼ Drug addiction is a serious problem for modern societies worldwide. There are remarkable costs associated with this problem, from the direct costs of the substance abuse treatment and prevention healthcare infrastructure to the less direct implications for the criminal justice system and social welfare programs. For individuals there is a loss of health, livelihood, interpersonal relationships, freedom, and ultimately life. The hallmark behavioral feature of addiction is a pattern of intermittent relapse lasting for decades after initial substance abuse. The research community has made a substantial investment of time and resources to better understand the etiology and fundamental features underlying addiction and relapse. Modern theories posit that addiction involves a recurring compulsion by an individual to engage in drug-seeking and drug-taking behaviors despite significant negative consequences. In humans, exposure to drug-associated stimuli and environmental contexts is known to induce an intense state of craving, independent of the length of time since acute drug exposure. Furthermore, neuroimaging studies of humans have suggested that basal ganglia structures may be involved in craving. Progress in the study of basal ganglia-mediated learning and memory has begun to outline a neuroanatomical substrate for the transition of egocentric, selfinitiated goal-directed behavior, to allocentric or externally driven behavior arising from exposure to environmental contexts or particular stimuli. While many elegant experiments have addressed the ability of drug-associated environmental contexts to affect behavior, the ability of discrete drug-associated sensory cues to affect behavior has been less thoroughly addressed. Discrete cues can become associated with drug use by two major operant learning mechanisms that vary in their temporal relationship to the subjective perception of primary reinforcement. The experiments described in this dissertation were designed to identify the extent to which discriminative stimuli and conditioned reinforcers activate the same or different populations of neurons in the dorsal striatum, the main input nucleus of the mammalian basal ganglia. This work has examined, in a novel experimental model of relapse, the capability of discrete sensory cues to elicit reinstatement of drug-seeking behavior and the expression of learning and memory related genes associated with this behavior.

Subjects/Keywords: Cocaine Abuse

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Riedy, M. D. (2010). Reinstatement of Cocaine-Seeking Behavior Induced by Discrete Sensory Cues and the Associated Immediate Early Gene Expression. (Doctoral Dissertation). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/442/rec/969

Chicago Manual of Style (16^th Edition):

Riedy, Matthew D. “Reinstatement of Cocaine-Seeking Behavior Induced by Discrete Sensory Cues and the Associated Immediate Early Gene Expression.” 2010. Doctoral Dissertation, University of Utah. Accessed April 11, 2021. http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/442/rec/969.

MLA Handbook (7^th Edition):

Riedy, Matthew D. “Reinstatement of Cocaine-Seeking Behavior Induced by Discrete Sensory Cues and the Associated Immediate Early Gene Expression.” 2010. Web. 11 Apr 2021.

Vancouver:

Riedy MD. Reinstatement of Cocaine-Seeking Behavior Induced by Discrete Sensory Cues and the Associated Immediate Early Gene Expression. [Internet] [Doctoral dissertation]. University of Utah; 2010. [cited 2021 Apr 11]. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/442/rec/969.

Council of Science Editors:

Riedy MD. Reinstatement of Cocaine-Seeking Behavior Induced by Discrete Sensory Cues and the Associated Immediate Early Gene Expression. [Doctoral Dissertation]. University of Utah; 2010. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/442/rec/969

3. Hamilton, Lindsey Rebecca. Neurobiological and Behavioral Phenotypes and Cocaine Self-Administration in Adult Rhesus Monkeys Exposed to Cocaine Throughout Gestation.

Degree: 2010, Wake Forest University

URL: http://hdl.handle.net/10339/30400

Maternal cocaine addiction is a significant public health problem yet

Subjects/Keywords: Cocaine

…Figure 2. A) Yawning Elicited by Quinpirole in Female  Prenatally Cocaine Exposed and… …Control  Monkeys  B) Yawning Elicited by Quinpirole in Male  Prenatally Cocaine Exposed and… …Peak Yawns Elicited by Quinpirole  and Maximal Daily Dose of In Utero Cocaine  107… …Effects of SKF 81297 on Eye‐Blinking Rates in  Prenatally Cocaine Exposed Monkeys  C) Group… …Delay Value �� Percentage Choice for  the Delayed Reinforcer Curves for a Prenatally  Cocaine…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hamilton, L. R. (2010). Neurobiological and Behavioral Phenotypes and Cocaine Self-Administration in Adult Rhesus Monkeys Exposed to Cocaine Throughout Gestation. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/30400

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hamilton, Lindsey Rebecca. “Neurobiological and Behavioral Phenotypes and Cocaine Self-Administration in Adult Rhesus Monkeys Exposed to Cocaine Throughout Gestation.” 2010. Thesis, Wake Forest University. Accessed April 11, 2021. http://hdl.handle.net/10339/30400.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hamilton, Lindsey Rebecca. “Neurobiological and Behavioral Phenotypes and Cocaine Self-Administration in Adult Rhesus Monkeys Exposed to Cocaine Throughout Gestation.” 2010. Web. 11 Apr 2021.

Vancouver:

Hamilton LR. Neurobiological and Behavioral Phenotypes and Cocaine Self-Administration in Adult Rhesus Monkeys Exposed to Cocaine Throughout Gestation. [Internet] [Thesis]. Wake Forest University; 2010. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/10339/30400.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hamilton LR. Neurobiological and Behavioral Phenotypes and Cocaine Self-Administration in Adult Rhesus Monkeys Exposed to Cocaine Throughout Gestation. [Thesis]. Wake Forest University; 2010. Available from: http://hdl.handle.net/10339/30400

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

4. Pattison, Lindsey Patricia. Functional Alterations in the Dopamine Transporter of Rodents following Self-Administration of Cocaine, Heroin and Speedball.

Degree: 2013, Wake Forest University

URL: http://hdl.handle.net/10339/38519

► Cocaine/heroin combinations (speedball) induce a synergistic elevation in extracellular dopamine (DA) concentrations ([DA]_e) in the nucleus accumbens (NAc) that can explain the continued patterns of… (more)

Subjects/Keywords: cocaine

…CHAPTER I Table 1. Effects of cocaine on the mesolimbic DA system Table 2. Compounds used… …combinations to elucidate mechanisms 23 of cocaine/heroin 40 CHAPTER II Figure 1… …Representative traces of evoked DA signals detected by FSCV in rat NAc before and 1 min after cocaine… …cocaine + 0.03 mg/kg heroin, i.v.) injection in drug-naïve animals (upper panel)… …cocaine (1.0 mg/kg), heroin (0.03 mg/kg) and speedball (1.0 mg/kg…

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APA (6^th Edition):

Pattison, L. P. (2013). Functional Alterations in the Dopamine Transporter of Rodents following Self-Administration of Cocaine, Heroin and Speedball. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/38519

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Pattison, Lindsey Patricia. “Functional Alterations in the Dopamine Transporter of Rodents following Self-Administration of Cocaine, Heroin and Speedball.” 2013. Thesis, Wake Forest University. Accessed April 11, 2021. http://hdl.handle.net/10339/38519.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Pattison, Lindsey Patricia. “Functional Alterations in the Dopamine Transporter of Rodents following Self-Administration of Cocaine, Heroin and Speedball.” 2013. Web. 11 Apr 2021.

Vancouver:

Pattison LP. Functional Alterations in the Dopamine Transporter of Rodents following Self-Administration of Cocaine, Heroin and Speedball. [Internet] [Thesis]. Wake Forest University; 2013. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/10339/38519.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pattison LP. Functional Alterations in the Dopamine Transporter of Rodents following Self-Administration of Cocaine, Heroin and Speedball. [Thesis]. Wake Forest University; 2013. Available from: http://hdl.handle.net/10339/38519

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

5. Brutcher, Robert Edwin. EFFECTS OF SLEEP DISRUPTION AND QUETIAPINE ON COCAINE ABUSE: THE PATH TO DEVELOPMENT OF A MONKEY MODEL OF PTSD.

Degree: 2013, Wake Forest University

URL: http://hdl.handle.net/10339/38531

► The goal of the current research is to systematically evaluate several components needed to develop a monkey model of post-traumatic stress disorder (PTSD). For this… (more)

Subjects/Keywords: Cocaine

…LIST OF FIGURES PAGE CHAPTER II Figure 1. Mean (± SD or SEM) cocaine-choice… …cocaine doses on (A) sleep efficiency, (B) sleep latency, and (C)… …cocaine baseline (A) and sleep disruption (B) �� …100 Figure 4. Mean (… …SEM) sleep measures during baseline cocaine conditions (light gray bars) and… …p < 0.01; n=7 �� …101 Figure 4. Mean (± SEM) percent of cocaine choice for…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Brutcher, R. E. (2013). EFFECTS OF SLEEP DISRUPTION AND QUETIAPINE ON COCAINE ABUSE: THE PATH TO DEVELOPMENT OF A MONKEY MODEL OF PTSD. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/38531

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Brutcher, Robert Edwin. “EFFECTS OF SLEEP DISRUPTION AND QUETIAPINE ON COCAINE ABUSE: THE PATH TO DEVELOPMENT OF A MONKEY MODEL OF PTSD.” 2013. Thesis, Wake Forest University. Accessed April 11, 2021. http://hdl.handle.net/10339/38531.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Brutcher, Robert Edwin. “EFFECTS OF SLEEP DISRUPTION AND QUETIAPINE ON COCAINE ABUSE: THE PATH TO DEVELOPMENT OF A MONKEY MODEL OF PTSD.” 2013. Web. 11 Apr 2021.

Vancouver:

Brutcher RE. EFFECTS OF SLEEP DISRUPTION AND QUETIAPINE ON COCAINE ABUSE: THE PATH TO DEVELOPMENT OF A MONKEY MODEL OF PTSD. [Internet] [Thesis]. Wake Forest University; 2013. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/10339/38531.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Brutcher RE. EFFECTS OF SLEEP DISRUPTION AND QUETIAPINE ON COCAINE ABUSE: THE PATH TO DEVELOPMENT OF A MONKEY MODEL OF PTSD. [Thesis]. Wake Forest University; 2013. Available from: http://hdl.handle.net/10339/38531

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Wake Forest University

6. Freeman, Willard Morgan. Functional Neurogenomics of Cocaine.

Degree: 2002, Wake Forest University

URL: http://hdl.handle.net/10339/14669

► Dissertation prepared under the direction of Kent E. Vrana, Ph.D., Associate Professor of Physiology and Pharmacology and Director of Graduate Studies Chronic cocaine abuse causes… (more)

▼ Dissertation prepared under the direction of Kent E. Vrana, Ph.D., Associate Professor of Physiology and Pharmacology and Director of Graduate Studies Chronic cocaine abuse causes altered neuronal gene expression, morphology, and physiology. These changes are thought to contribute to an allostatic state of behavior characterized by compulsive drug seeking, sensitization, tolerance, withdrawal and psychological dependence. Through the use of cDNA hybridization arrays and immunoreactive protein quantification, gene expression analysis can be carried out on a functional neurogenomic scale. This dissertation research identifies changes in gene expression across three animal models of chronic cocaine administration (non-contigent non-human primate, non-contingent rat, and self-administering rat), and three brain regions, (nucleus accumbens, frontal cortex, and hippocampus). In the non-human primate, chronic cocaine induced the expression of protein tyrosine kinase 2, mitogen activated protein kinase kinase, â-catenin, and protein kinase A á catalytic subunit. While each of these genes has important cellular effects, the prime finding of the study was that they all serve to activate cyclic AMP response element binding protein or activator protein 1, known mediators of cocaine-responsive gene expression x and behavior. In the non-contingent rodent model, hippocampal expression of protein kinase Cá, protein kinase Cå, metabotropic glutamate receptor 5, potassium channel Kv1.1, protein tyrosine kinase 2, and â-catenin were induced by cocaine. Each of these genes could potentially have a number of effects, but, interestingly, some of the changes observed could act in an antagonistic manner. In the rat frontal cortex, induction of protein tyrosine kinase 2, activity-regulated cytoskeletal protein, and a nuclear receptor 77 related antigen were seen with chronic cocaine administration. In the rat nucleus accumbens, protein tyrosine kinase 2 protein was shown to be significantly up-regulated. Initial hybridization array analysis of cocaine self-administering rats has produced a number of potentially cocaineresponsive genes, some of which were observed in the non-contingent rat model. These studies demonstrate that some changes in gene expression are specific to certain regions of the brain and others are more ubiquitous. These changes in gene expression provide hypotheses for future research into the role of functional neurogenomics in physiology and behavior, and may provide potential targets for pharmacotherapeutic intervention.

Subjects/Keywords: Cocaine

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Freeman, W. M. (2002). Functional Neurogenomics of Cocaine. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/14669

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Freeman, Willard Morgan. “Functional Neurogenomics of Cocaine.” 2002. Thesis, Wake Forest University. Accessed April 11, 2021. http://hdl.handle.net/10339/14669.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Freeman, Willard Morgan. “Functional Neurogenomics of Cocaine.” 2002. Web. 11 Apr 2021.

Vancouver:

Freeman WM. Functional Neurogenomics of Cocaine. [Internet] [Thesis]. Wake Forest University; 2002. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/10339/14669.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Freeman WM. Functional Neurogenomics of Cocaine. [Thesis]. Wake Forest University; 2002. Available from: http://hdl.handle.net/10339/14669

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Houston

7. Mahoney, James J. Pharmacological Approaches to Remediate Neurocognitive Impairment in Cocaine-Dependent Individuals.

Degree: PhD, Counseling Psychology, 2014, University of Houston

URL: http://hdl.handle.net/10657/4754

► The goal of this study was to determine whether demographic (e.g. ethnicity, gender, etc.), drug use (e.g. years of cocaine use, days cocaine used in… (more)

▼ The goal of this study was to determine whether demographic (e.g. ethnicity, gender, etc.), drug use (e.g. years of cocaine use, days cocaine used in the past 30, comorbid substance use, etc.), or mood (BDI-II, LSC-R, and ASI-Lite scores) variables affected neurocognitive functioning in cocaine-dependent participants. In addition, two candidate medications were evaluated to assess whether they have the potential to improve neurocognitive functioning in cocaine-dependent individuals. There were two separate studys as part of this dissertation. Study 1 involved the investigation of demographic and drug use variables contributing to neurocognitive deficits in 125 cocaine dependent individuals. Study 2 compared the efficacy of two acetylcholinesterase inhibitors: rivastigmine and huperzine (as well as a control group randomized to receive placebo) as potential treatments for cocaine-induced neurocognitive impairment. Twenty-eight individuals were randomized to receive rivastigmine, 29 were randomized to receive huperzine, and 15 were randomized to receive placebo. Before study medication randomization, participants completed a battery of neurocognitive assessments and completed the same battery of assessments following 8 days of medication/placebo treatment. One of the factors that detrimentally affects cocaine-dependent individuals as they seek treatment is the presence of neurocognitive deficits produced or exacerbated by cocaine use. Since long-term, high-dose cocaine use is a risk factor for the onset of neurocognitive impairment in humans, it is critical that these deficits be addressed in order to improve treatment outcomes. Study 1 utilized only baseline data (independent of any medication treatment) and Study 2 used both pre-treatment (baseline, before medication administration) and post-treatment (following medication administration) data. Pearson product moment correlations and analysis of variance (ANOVA) were used to evaluate the association between demographic and drug use variables and performance on the neurocognitive measures. ANOVA was used to evaluate medication versus placebo effects on test performance pre- and post-treatment. Study 1 revealed that there were no gender or race differences in neurocognition between groups. Further, comorbid substance use (e.g. nicotine, alcohol, or marijuana) did not affect neurocognition. Study 2 showed that treatment with rivastigmine significantly improved episodic memory, though treatment with huperzine did not affect neurocognition. On the basis of outcomes from Study 1 and Study 2, we contend that cocaine associated neurocognitive impairment remains an important target of treatment. Given that cocaine addiction is associated with widespread functional difficulties, such as unemployment and relapse to dependence, it is plausible that reversing neurocognitive impairments will ameliorate these functional difficulties. Advisors/Committee Members: Dao, Tam K. (advisor), Olvera, Norma E. (committee member), Day, Susan X. (committee member), De La Garza, Richard, II (committee member).

Subjects/Keywords: Cocaine; Cognition

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mahoney, J. J. (2014). Pharmacological Approaches to Remediate Neurocognitive Impairment in Cocaine-Dependent Individuals. (Doctoral Dissertation). University of Houston. Retrieved from http://hdl.handle.net/10657/4754

Chicago Manual of Style (16^th Edition):

Mahoney, James J. “Pharmacological Approaches to Remediate Neurocognitive Impairment in Cocaine-Dependent Individuals.” 2014. Doctoral Dissertation, University of Houston. Accessed April 11, 2021. http://hdl.handle.net/10657/4754.

MLA Handbook (7^th Edition):

Mahoney, James J. “Pharmacological Approaches to Remediate Neurocognitive Impairment in Cocaine-Dependent Individuals.” 2014. Web. 11 Apr 2021.

Vancouver:

Mahoney JJ. Pharmacological Approaches to Remediate Neurocognitive Impairment in Cocaine-Dependent Individuals. [Internet] [Doctoral dissertation]. University of Houston; 2014. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/10657/4754.

Council of Science Editors:

Mahoney JJ. Pharmacological Approaches to Remediate Neurocognitive Impairment in Cocaine-Dependent Individuals. [Doctoral Dissertation]. University of Houston; 2014. Available from: http://hdl.handle.net/10657/4754

Texas Tech University

8. Vaz, Berchman Austin. Effects of cocaine on macrophage functions: Phagocytosis and activation to the cytotoxic state.

Degree: TTUHSC – Immunology and Infectious Diseases, 1993, Texas Tech University

URL: http://hdl.handle.net/2346/17917

► One of the most "fashionable" as well as dangerous drugs abused in this country is cocaine. Very little is known about the effects of cocaine… (more)

▼ One of the most "fashionable" as well as dangerous drugs abused in this country is cocaine. Very little is known about the effects of cocaine on the immune system. Since macrophages play a central role in both the cellular and the humoral arms of the immune system, this study focused on the effects of cocaine on murine peritoneal macrophage functions, viz., phagocytosis and activation to the cytotoxic state. Phagocytosis is one of the most important components of the host defenses against invading microorganisms once the outer epithelial surface of the body has been breached. In the present study, cocaine injected intraperitoneally was found to increase phagocytic activity of isolated macrophages in vitro; but decreased it when measured by an in vivo assay. The respiratory burst, which is usually correlated with phagocytosis, was enhanced by cocaine. Macrophage activation was studied by measuring macrophage- mediated cytotoxicity (MMC), i.e., the acquisition of competence to destroy neoplastic cells in the absence of antibody. Macrophages from cocaine-injected mice demonstrated a reduced capacity for killing neoplastic cells; as well as a reduction in the secretion of reactive nitrogen intermediates. The latter represent a major product used by macrophages to kill cells. Macrophage receptors/ surface proteins involved in phagocytosis and activation were studied using flow cytometry. A number of these surface receptors were dramatically altered by exposure to cocaine. The presumed toxic metabolites of cocaine, benzoylecgonine and norcocaine, were found to have similar effects on macrophage functions. The present studies clearly demonstrate that cocaine affeas phagocytosis and activation to the cytotoxic state. This translates into impairment of certain non-specific immune responses. These results taken in their entirety suggest that the ability of cocaine to alter macrophage functions could modify specific immune responses resulting in a compromised immune system.

Subjects/Keywords: Cocaine

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Vaz, B. A. (1993). Effects of cocaine on macrophage functions: Phagocytosis and activation to the cytotoxic state. (Thesis). Texas Tech University. Retrieved from http://hdl.handle.net/2346/17917

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Vaz, Berchman Austin. “Effects of cocaine on macrophage functions: Phagocytosis and activation to the cytotoxic state.” 1993. Thesis, Texas Tech University. Accessed April 11, 2021. http://hdl.handle.net/2346/17917.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Vaz, Berchman Austin. “Effects of cocaine on macrophage functions: Phagocytosis and activation to the cytotoxic state.” 1993. Web. 11 Apr 2021.

Vancouver:

Vaz BA. Effects of cocaine on macrophage functions: Phagocytosis and activation to the cytotoxic state. [Internet] [Thesis]. Texas Tech University; 1993. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/2346/17917.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Vaz BA. Effects of cocaine on macrophage functions: Phagocytosis and activation to the cytotoxic state. [Thesis]. Texas Tech University; 1993. Available from: http://hdl.handle.net/2346/17917

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Michigan

9. Brim, Remy Leigh. Investigations into the Therapeutic Potential of a Bacterial Cocaine Esterase for the Treatment of Cocaine Toxicity and Cocaine Abuse.

Degree: PhD, Pharmacology, 2011, University of Michigan

URL: http://hdl.handle.net/2027.42/84448

► Cocaine use is a widespread problem in the United States with 2 million current users who make about half a million emergency department visits each… (more)

▼ Cocaine use is a widespread problem in the United States with 2 million current users who make about half a million emergency department visits each year. Although use is prevalent, there is currently no FDA-approved pharmacotherapy to specifically treat cocaine abuse or cocaine toxicity. Approaches toward developing therapies for these indications include small molecule inhibitors of cocaine binding and cocaine vaccines. These methods have proven to block the strong reinforcing properties of the drug; however, they do not prevent nor reverse cocaine’s serious physiological effects. Our approach to treating cocaine toxicity and abuse is to rapidly hydrolyze the cocaine molecule into inactive metabolites using a bacterial cocaine esterase (CocE), thus eliminating cocaine’s harmful and strong reinforcing effects. This work has taken major steps toward developing CocE into a viable pharmacotherapy for both cocaine addiction and toxicity. Initially two thermostabilizing mutations were combined to improve the half-life of CocE. This mutant was pharmacologically characterized in vitro as well as in vivo using rodent models of cocaine lethality and reinforcement. The pharmacodynamic and pharmacokinetic properties of CocE, including in vivo rates of cocaine hydrolysis across species, circulating half-life, and mechanisms of elimination, were assessed. CocE’s capacity to hydrolyze cocaine in the presence of commonly co-abused drugs, and its capacity to hydrolyze active cocaine metabolites were investigated. The results from these studies support the notion that cocaine esterase displays strong therapeutic potential, and that it may proceed towards clinical development. Moreover, it is a comprehensive analysis of how protein biologics may be used as effective pharmacotherapeutics. Advisors/Committee Members: Sunahara, Roger K. (committee member), Woods, James H. (committee member), Gnegy, Margaret E. (committee member), Lukacs, Nicholas W. (committee member), Tesmer, John (committee member).

Subjects/Keywords: Cocaine; Protein-based Theraputic; Cocaine Esterase; Cocaine Abuse; Cocaine Toxicity; Pharmacy and Pharmacology; Health Sciences

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APA (6^th Edition):

Brim, R. L. (2011). Investigations into the Therapeutic Potential of a Bacterial Cocaine Esterase for the Treatment of Cocaine Toxicity and Cocaine Abuse. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/84448

Chicago Manual of Style (16^th Edition):

Brim, Remy Leigh. “Investigations into the Therapeutic Potential of a Bacterial Cocaine Esterase for the Treatment of Cocaine Toxicity and Cocaine Abuse.” 2011. Doctoral Dissertation, University of Michigan. Accessed April 11, 2021. http://hdl.handle.net/2027.42/84448.

MLA Handbook (7^th Edition):

Brim, Remy Leigh. “Investigations into the Therapeutic Potential of a Bacterial Cocaine Esterase for the Treatment of Cocaine Toxicity and Cocaine Abuse.” 2011. Web. 11 Apr 2021.

Vancouver:

Brim RL. Investigations into the Therapeutic Potential of a Bacterial Cocaine Esterase for the Treatment of Cocaine Toxicity and Cocaine Abuse. [Internet] [Doctoral dissertation]. University of Michigan; 2011. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/2027.42/84448.

Council of Science Editors:

Brim RL. Investigations into the Therapeutic Potential of a Bacterial Cocaine Esterase for the Treatment of Cocaine Toxicity and Cocaine Abuse. [Doctoral Dissertation]. University of Michigan; 2011. Available from: http://hdl.handle.net/2027.42/84448

10. Boyle, Cody Adam. Intergenerational Effects Of Embryonic Cocaine Exposure In Zebrafish.

Degree: MS, Biology, 2017, University of North Dakota

URL: https://commons.und.edu/theses/2174

► Cocaine addiction has both genetic and environmentally driven components. Relatively recently several groups have suggested that epigenetic regulation of gene expression might be the… (more)

Subjects/Keywords: Cocaine; Intergenerational; Zebrafish

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APA (6^th Edition):

Boyle, C. A. (2017). Intergenerational Effects Of Embryonic Cocaine Exposure In Zebrafish. (Masters Thesis). University of North Dakota. Retrieved from https://commons.und.edu/theses/2174

Chicago Manual of Style (16^th Edition):

Boyle, Cody Adam. “Intergenerational Effects Of Embryonic Cocaine Exposure In Zebrafish.” 2017. Masters Thesis, University of North Dakota. Accessed April 11, 2021. https://commons.und.edu/theses/2174.

MLA Handbook (7^th Edition):

Boyle, Cody Adam. “Intergenerational Effects Of Embryonic Cocaine Exposure In Zebrafish.” 2017. Web. 11 Apr 2021.

Vancouver:

Boyle CA. Intergenerational Effects Of Embryonic Cocaine Exposure In Zebrafish. [Internet] [Masters thesis]. University of North Dakota; 2017. [cited 2021 Apr 11]. Available from: https://commons.und.edu/theses/2174.

Council of Science Editors:

Boyle CA. Intergenerational Effects Of Embryonic Cocaine Exposure In Zebrafish. [Masters Thesis]. University of North Dakota; 2017. Available from: https://commons.und.edu/theses/2174

Victoria University of Wellington

11. Morani, Aashish Sultan. Behavioural Pharmacology of Novel Kappa Opioid Compounds.

Degree: 2011, Victoria University of Wellington

URL: http://hdl.handle.net/10063/4446

► Rationale: Kappa opioid receptor (KOPr) activation by traditional agonists has been shown to produce anti-addiction behaviours. However, adverse effects such as sedation, aversion and depression… (more)

▼ Rationale: Kappa opioid receptor (KOPr) activation by traditional agonists has been shown to produce anti-addiction behaviours. However, adverse effects such as sedation, aversion and depression have limited their clinical development. Recently, salvinorin A (Sal A), an active component of the plant Salvia divinorum was shown to be a potent and selective KOPr agonist. Sal A has a short duration of effect and quick onset of action. It also produces similar behavioural pharmacology to traditional KOPr agonists. However, little is known about the anti-addiction profile of Sal A. If Sal A and its structural analogues produce anti-addiction properties with fewer adverse effects compared to traditional KOPr agonists, they have potential to be developed into antiaddiction pharmacotherapies. Therefore, Sal A and its structural analogues (DS1, MOM Sal B, EOM Sal B, herkinorin) and Mu opioid receptor (MOPr) antagonist/partial KOPr agonist, nalmefene were tested for their behavioural anti-addiction and adverse effect profiles in rats. Methods: To test the anti-addiction profile, a within session cocaine prime induced reinstatement paradigm was used. The selectivity of KOPr agonists in attenuating cocaine seeking behaviours was tested using sucrose reinforcement (anhedonia) and cocaine induced hyperactivity in self-administering rats (sedation during reinstatement test). Furthermore, behavioural adverse effects were screened using spontaneous open field activity (motor suppression), conditioned taste aversion (aversion) and forced swim test (depression) in rats. To further quantify the anti-addiction behaviours, the effect of KOPr agonists which attenuated drug seeking selectively without producing motor suppression by themselves were tested for cocaine produced motor function (hyperactivity and behavioural sensitization) in rats. The effect of serotonin transporter blockade on KOPr agonist induced depressive behaviour was also tested. The effects of KOPr activation on in vitro serotonin transporter function were also determined. Results: Sal A, DS1 and nalmefene attenuated cocaine prime induced drug-seeking, in a selective manner, via KOPr activation. MOM Sal B, a more potent and long acting Sal A analogue attenuated cocaine seeking in a non-selective manner. Sal A, DS1 and nalmefene did not induce aversion, however nalmefene suppressed motor function, which was not seen with Sal A and DS1. Furthermore, Sal A and DS1 suppressed cocaine behavioural sensitization. All three compounds (Sal A, DS1, nalmefene) produced depression. The depressive effects produced by Sal A and DS1 were diminished by blocking the serotonin transporter. Live-cell serotonin transporter assays showed potential differences between traditional (U50488H) and novel (Sal A, DS1) KOPr agonists in their ability to modulate serotonin transporter function. Conclusion: Out of six KOPr compounds tested, Sal A, DS1, MOM Sal B and nalmefene produced anti-addiction behaviours. However, MOM Sal B exposure also suppressed natural reward seeking behaviour. Sal A and DS1… Advisors/Committee Members: Kivell, Bronwyn, Schenk, Susan.

Subjects/Keywords: Cocaine; Salvinorin; Pharmacology

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APA (6^th Edition):

Morani, A. S. (2011). Behavioural Pharmacology of Novel Kappa Opioid Compounds. (Doctoral Dissertation). Victoria University of Wellington. Retrieved from http://hdl.handle.net/10063/4446

Chicago Manual of Style (16^th Edition):

Morani, Aashish Sultan. “Behavioural Pharmacology of Novel Kappa Opioid Compounds.” 2011. Doctoral Dissertation, Victoria University of Wellington. Accessed April 11, 2021. http://hdl.handle.net/10063/4446.

MLA Handbook (7^th Edition):

Morani, Aashish Sultan. “Behavioural Pharmacology of Novel Kappa Opioid Compounds.” 2011. Web. 11 Apr 2021.

Vancouver:

Morani AS. Behavioural Pharmacology of Novel Kappa Opioid Compounds. [Internet] [Doctoral dissertation]. Victoria University of Wellington; 2011. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/10063/4446.

Council of Science Editors:

Morani AS. Behavioural Pharmacology of Novel Kappa Opioid Compounds. [Doctoral Dissertation]. Victoria University of Wellington; 2011. Available from: http://hdl.handle.net/10063/4446

University of Texas – Austin

12. Will, Ryan Gregory. The role of the preoptic area in response to cocaine.

Degree: PhD, Psychology, 2016, University of Texas – Austin

URL: http://hdl.handle.net/2152/39723

► The preoptic area of the hypothalamus is ideally suited to modulate the behavioral and neural response to drugs of abuse such as cocaine. The preoptic… (more)

Subjects/Keywords: Preoptic area; Cocaine

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APA (6^th Edition):

Will, R. G. (2016). The role of the preoptic area in response to cocaine. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/39723

Chicago Manual of Style (16^th Edition):

Will, Ryan Gregory. “The role of the preoptic area in response to cocaine.” 2016. Doctoral Dissertation, University of Texas – Austin. Accessed April 11, 2021. http://hdl.handle.net/2152/39723.

MLA Handbook (7^th Edition):

Will, Ryan Gregory. “The role of the preoptic area in response to cocaine.” 2016. Web. 11 Apr 2021.

Vancouver:

Will RG. The role of the preoptic area in response to cocaine. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2016. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/2152/39723.

Council of Science Editors:

Will RG. The role of the preoptic area in response to cocaine. [Doctoral Dissertation]. University of Texas – Austin; 2016. Available from: http://hdl.handle.net/2152/39723

University of Kentucky

13. Zheng, Xirong. Pharmacokinetic and Pharmacodynamic Evaluation of Cocaine Hydrolases for the Treatment of Cocaine Overdose and Cocaine Addiction Using Rodent Models.

Degree: 2019, University of Kentucky

URL: https://uknowledge.uky.edu/pharmacy_etds/102

► Overdose and addiction are two medical complications of cocaine abuse. To date, there is no FDA approved pharmacotherapy specific for cocaine abuse. Cocaine hydrolases (CocHs)… (more)

▼ Overdose and addiction are two medical complications of cocaine abuse. To date, there is no FDA approved pharmacotherapy specific for cocaine abuse. Cocaine hydrolases (CocHs) have been extensively investigated for its potential in anti-cocaine therapy. Previous studies have demonstrated that CocHs efficiently hydrolyze cocaine to generate biologically inactive metabolites both in vivo and in vitro. However, it has not been studied whether there is gender difference in the therapy using CocHs. In addition, the effectiveness of CocHs is unknown for treating cocaine toxicity when alcohol is co-administered. The main purpose of this dissertation is to characterize and evaluate efficient CocHs for cocaine overdose and cocaine addiction treatment. In the first set of studies, the effectiveness of human serum albumin-fused CocH1 were studied in male and female rats. The pharmacokinetic profiles, as well as the pharmacodynamic effects of CocH1-HSA were compared in male and female rats. The obtained data clearly demonstrated that CocH1-HSA was equally effective in both genders. The second set of studies investigated the efficiency of Fc-fused CocH5 in reversing cocaine toxicity in rats receiving simultaneous administration of cocaine and alcohol. Results showed that CocH5-Fc rapidly hydrolyzed cocaine and cocaine’s toxic metabolites in rats, and demonstrated that CocH5-Fc was efficient in treating cocaine toxicity when alcohol was simultaneously administered. In later studies to investigate the effects of CocH5-Fc for the treatment of cocaine addiction, a mathematical model was developed and validated to predict the effects of CocH5-Fc on the disposition of cocaine in rat blood and brain. This model adequately described the effects of CocH5-Fc in accelerating the elimination of cocaine and its toxic metabolites in both rat blood and brain. In conclusion, the studies within the current dissertation demonstrate the clinical potential of CocHs for the treatment of both cocaine overdose and cocaine addiction.

Subjects/Keywords: cocaine overdose; cocaine addiction; cocaine hydrolase; mathematical model; Pharmaceutics and Drug Design

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APA (6^th Edition):

Zheng, X. (2019). Pharmacokinetic and Pharmacodynamic Evaluation of Cocaine Hydrolases for the Treatment of Cocaine Overdose and Cocaine Addiction Using Rodent Models. (Doctoral Dissertation). University of Kentucky. Retrieved from https://uknowledge.uky.edu/pharmacy_etds/102

Chicago Manual of Style (16^th Edition):

Zheng, Xirong. “Pharmacokinetic and Pharmacodynamic Evaluation of Cocaine Hydrolases for the Treatment of Cocaine Overdose and Cocaine Addiction Using Rodent Models.” 2019. Doctoral Dissertation, University of Kentucky. Accessed April 11, 2021. https://uknowledge.uky.edu/pharmacy_etds/102.

MLA Handbook (7^th Edition):

Zheng, Xirong. “Pharmacokinetic and Pharmacodynamic Evaluation of Cocaine Hydrolases for the Treatment of Cocaine Overdose and Cocaine Addiction Using Rodent Models.” 2019. Web. 11 Apr 2021.

Vancouver:

Zheng X. Pharmacokinetic and Pharmacodynamic Evaluation of Cocaine Hydrolases for the Treatment of Cocaine Overdose and Cocaine Addiction Using Rodent Models. [Internet] [Doctoral dissertation]. University of Kentucky; 2019. [cited 2021 Apr 11]. Available from: https://uknowledge.uky.edu/pharmacy_etds/102.

Council of Science Editors:

Zheng X. Pharmacokinetic and Pharmacodynamic Evaluation of Cocaine Hydrolases for the Treatment of Cocaine Overdose and Cocaine Addiction Using Rodent Models. [Doctoral Dissertation]. University of Kentucky; 2019. Available from: https://uknowledge.uky.edu/pharmacy_etds/102

Temple University

14. Craige, Caryne. Regulation of Cocaine-induced Behaviors and Anxiety Produced by Cocaine Withdrawal through the Serotonin(2C) Receptor.

Degree: PhD, 2013, Temple University

URL: http://digital.library.temple.edu/u?/p245801coll10,239587

►

Pharmacology

Cocaine is a powerfully active psychostimulant which exerts its effects through blockade of dopamine, serotonin and norepinephrine transporters and resultant increases in extracellular levels… (more)

▼

Pharmacology

Cocaine is a powerfully active psychostimulant which exerts its effects through blockade of dopamine, serotonin and norepinephrine transporters and resultant increases in extracellular levels of these neurotransmitters. Much of the focus on cocaine abuse in the literature has been directed towards study of the dopamine system; however, several studies have identified a role for the serotonin system in regulating the rewarding effects of cocaine as well. Specifically, the serotonin 2C (5-HT2C) receptor regulates cocaine-induced alterations in serotonin and dopamine levels in an inhibitory manner, and 5-HT2C receptor agonist treatment attenuates cocaine-induced behaviors like self-administration. In the first aspect of the current thesis study, the effects of activation of 5-HT2C receptors on cocaine-induced conditioned place preference and behavioral sensitization were assessed. It was found that pretreatment with a 5-HT2C receptor agonist, Ro 60-0175, on cocaine (10 mg/kg) conditioning days of the conditioned place preference paradigm, attenuated the development of conditioned place preference in a dose-dependent manner. These results suggest that activation of 5-HT2C receptors inhibits the euphoric effects elicited by cocaine. Behavioral sensitization studies demonstrated that pretreatment with Ro 60-0175 prior to cocaine (10 mg/kg) over a 5 day period attenuated cocaine-induced hyperactivity. When injected with a cocaine challenge injection 10 days after the last cocaine injection, mice pretreated with Ro 60-0175 demonstrated lower levels of locomotor activity as compared to saline pretreated, cocaine-injected mice. This portion of the first study demonstrated that 5-HT2C receptor activity attenuated acute cocaine-induced conditioned reward, hyperactivity and the development of long-term alterations of cocaine exposure, as measured by behavioral sensitization. The second aspect of the current study focused on the regulation of anxiety produced by withdrawal from chronic cocaine administration. Anxiety during cocaine withdrawal is a component of the negative affective state often experienced by cocaine-dependent individuals during abstinence from drug use. Anxiety during cocaine withdrawal is likely to increase an individual's susceptibility to relapse to drug use in alleviation of this negative symptom. Studies have shown a downregulation of the serotonin and dopamine systems during withdrawal that potentially contributes to anxiety symptoms. As the 5-HT2C receptor exerts inhibitory control over both the serotonin and dopamine systems, it was hypothesized that blockade of 5-HT2C receptors would attenuate anxiety-like behavior during cocaine withdrawal. Previous studies have identified co-localization of 5-HT2C receptors on inhibitory gamma-aminobutyric acid (GABA) neurons, thus it was hypothesized that a 5-HT2C receptor-GABA mediated mechanism would be involved in the regulation of anxiety during withdrawal. The dorsal raphe brain region was targeted in these studies, as this region is the primary…

Advisors/Committee Members: Unterwald, Ellen M., Kirby, Lynn;, Bangasser, Debra, Dun, Nae J., Rawls, Scott M., Beck, Sheryl G.;.

Subjects/Keywords: Neurosciences; Pharmacology;

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APA (6^th Edition):

Craige, C. (2013). Regulation of Cocaine-induced Behaviors and Anxiety Produced by Cocaine Withdrawal through the Serotonin(2C) Receptor. (Doctoral Dissertation). Temple University. Retrieved from http://digital.library.temple.edu/u?/p245801coll10,239587

Chicago Manual of Style (16^th Edition):

Craige, Caryne. “Regulation of Cocaine-induced Behaviors and Anxiety Produced by Cocaine Withdrawal through the Serotonin(2C) Receptor.” 2013. Doctoral Dissertation, Temple University. Accessed April 11, 2021. http://digital.library.temple.edu/u?/p245801coll10,239587.

MLA Handbook (7^th Edition):

Craige, Caryne. “Regulation of Cocaine-induced Behaviors and Anxiety Produced by Cocaine Withdrawal through the Serotonin(2C) Receptor.” 2013. Web. 11 Apr 2021.

Vancouver:

Craige C. Regulation of Cocaine-induced Behaviors and Anxiety Produced by Cocaine Withdrawal through the Serotonin(2C) Receptor. [Internet] [Doctoral dissertation]. Temple University; 2013. [cited 2021 Apr 11]. Available from: http://digital.library.temple.edu/u?/p245801coll10,239587.

Council of Science Editors:

Craige C. Regulation of Cocaine-induced Behaviors and Anxiety Produced by Cocaine Withdrawal through the Serotonin(2C) Receptor. [Doctoral Dissertation]. Temple University; 2013. Available from: http://digital.library.temple.edu/u?/p245801coll10,239587

Texas A&M University

15. Valles, Rodrigo, Jr. Behavioral mechanisms underlying the extinction of cocaine self-administration.

Degree: PhD, Psychology, 2006, Texas A&M University

URL: http://hdl.handle.net/1969.1/3105

► The aim of the present series of experiments was to outline the influence of different doses of cocaine during training, training schedule, training length and… (more)

▼ The aim of the present series of experiments was to outline the influence of different doses of cocaine during training, training schedule, training length and abstinence duration to modulate subsequent extinction and reinstatement patterns. Abram AmselÂs general theory of persistence were used to both design and explain various aspects of these models. For Experiment 1, rats self-administered cocaine (0.25, 0.50 or 1.00 mg/kg) intravenously and were then tested in an extinction preparation using saline infusions (5 days) and then only the stimulus light as the reinforcer (3 days). Experiment 2 examined schedules by magnitude interactions by training rats on two fixed-ratio (FR) schedules (FR-1 or FR-10 using either 0.25 or 1.00 mg/kg cocaine). Animals were tested in an extinction protocol (10 days; no stimulus light) and subsequently tested for reinstatement (1 day) that utilized presentations of the stimulus light. Experiment 3 addressed the effects of training length (15 or 30 days of training using either 0.25 or 1.00 mg/kg cocaine) using the same protocol as in Experiment 2. Experiment 4 examined the modulation potential of two abstinence lengths (15 or 30 days using either 0.25 or 0.50 mg/kg cocaine) using the same conditions as Experiment 2. Experiment 1 indicated the greatest resistance to extinction using the lowest training dose (0.25 mg/kg). The removal of saline caused an apparent extinction burst indicative of reward seeking. Experiment 2 showed that animals trained under partial reinforcement schedules persisted more during extinction. Furthermore, rats trained using 1.00 were more resistant than those trained with 0.25 mg/kg. Reinstatement of drug seeking was more pronounced in rats trained using an FR-10 schedule. Experiment 3 indicated greater resistance to extinction in rats trained for 15 versus 30 days. Rats trained on 0.50 mg/kg for 30 days showed less cue-induced reinstatement than those trained for 15 days. Experiment 4 showed increased resistance to extinction when rats were trained on 0.25 mg/kg and forced to abstain for 30 versus 15 days. Directionally opposite effects were apparent in groups trained with 0.50 mg/kg. Reinstatement data indicated greater responsivity to cues by animals abstaining for 30 versus 15 days. Advisors/Committee Members: Nation, Jack R (advisor), Bratton, Gerald R (committee member), Setlow, Barry (committee member), Wellman, Paul J (committee member).

Subjects/Keywords: Extinction; Cocaine

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APA (6^th Edition):

Valles, Rodrigo, J. (2006). Behavioral mechanisms underlying the extinction of cocaine self-administration. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/3105

Chicago Manual of Style (16^th Edition):

Valles, Rodrigo, Jr. “Behavioral mechanisms underlying the extinction of cocaine self-administration.” 2006. Doctoral Dissertation, Texas A&M University. Accessed April 11, 2021. http://hdl.handle.net/1969.1/3105.

MLA Handbook (7^th Edition):

Valles, Rodrigo, Jr. “Behavioral mechanisms underlying the extinction of cocaine self-administration.” 2006. Web. 11 Apr 2021.

Vancouver:

Valles, Rodrigo J. Behavioral mechanisms underlying the extinction of cocaine self-administration. [Internet] [Doctoral dissertation]. Texas A&M University; 2006. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/1969.1/3105.

Council of Science Editors:

Valles, Rodrigo J. Behavioral mechanisms underlying the extinction of cocaine self-administration. [Doctoral Dissertation]. Texas A&M University; 2006. Available from: http://hdl.handle.net/1969.1/3105

University of Texas Southwestern Medical Center

16. Jester, Bryan Elliott. Examining the Relationship Between Impulsive Personalities and Neural Functioning in Cocaine-Addicted Participants.

Degree: 2013, University of Texas Southwestern Medical Center

URL: http://hdl.handle.net/2152.5/1308

► BACKGROUND: Those who suffer from addiction are unable to discontinue use despite serious consequences affecting their social, professional, and family lives. Individuals who suffer from… (more)

▼ BACKGROUND: Those who suffer from addiction are unable to discontinue use despite serious consequences affecting their social, professional, and family lives. Individuals who suffer from the disorder often alienate themselves from loved ones and lose their jobs. Addiction involves continuing a behavior despite severe negative consequences. Numerous studies have identified a relationship between impulsivity and the development of substance abuse. This study examines the relationship of impulsive personality facets and neural functioning associated with inhibition. SUBJECTS: The study sample included 24 healthy control participants and 56 cocaine-addicted participants. Participants ranged in age from 25 to 54 years old with a mean age of 43.27 (±SD 7.84). The group was comprised of 68 male and 12 female participants, 28.7% self identified as Caucasian, 66.3% African American, 3.8% Hispanic, and 1.3% Asian/Other. Healthy controls and cocaine-addicted participants were similar in age and race but differed in gender (p= .02). The control group had 17 males and 7 females while the cocaine-addicted group had 51 males and 5 females. METHODS: Demographic information was gathered for all participants. Each participant also completed a Neuroticism Extroversion and Openness (NEO) personality measure and Temperament and Character Inventory (TCI), Structured Clinical Interview for DSM-IV (SCID), Wechsler Test of Adult Reading (WTAR). They then performed the stop signal task (SST) during functional magnetic resonance imaging (fMRI) to gather data on neural activation during Stop-Success (SS) and Stop-Failure (SF). fMRI data was analyzed using FSL imaging software. All statistics were run with SPSS software. Functional ROIs were identified and analyzed in fMRI Expert Analysis Tool query (FEATqueary) to gather data on each participantÕs change in blood oxygen level dependent (BOLD) activation during Stop-Success (SS) and Stop-Failure (SF). Impulsive personality facets were then used to identify relationships between BOLD activations of the ROIs. RESULTS: Between group comparisons found significant differences in mean scores on all of the impulsive personality facets except for Exploratory Excitability and Persistence from the TCI, and Excitement Seeking from the NEO. Neuroimaging results are similar to other studies utilizing the SST finding changes in activation of the middle frontal gyrus, superior frontal gyrus, cingulate gyrus, medial frontal gyrus, insula, caudate and supramarginal gyrus during Stop-Failure; and superior parietal lobule, middle frontal gyrus, precuneus, supramarginal gyrus, inferior temporal gyrus, and middle occipital gyrus during Stop-Success. However, no differences in BOLD activation between groups were observed. Numerous relationships were identified between the personality facets and BOLD activation of the regions of interest (ROIs). To further elucidate this relationship between neural functioning and personality a principal component analysis (PCA) was conducted on all eleven personality facets. The… Advisors/Committee Members: Adinoff, Bryon H., North, Carol S., Spence, Jeffrey.

Subjects/Keywords: Impulsive Behavior; Cocaine-Related Disorders

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APA (6^th Edition):

Jester, B. E. (2013). Examining the Relationship Between Impulsive Personalities and Neural Functioning in Cocaine-Addicted Participants. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/1308

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jester, Bryan Elliott. “Examining the Relationship Between Impulsive Personalities and Neural Functioning in Cocaine-Addicted Participants.” 2013. Thesis, University of Texas Southwestern Medical Center. Accessed April 11, 2021. http://hdl.handle.net/2152.5/1308.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jester, Bryan Elliott. “Examining the Relationship Between Impulsive Personalities and Neural Functioning in Cocaine-Addicted Participants.” 2013. Web. 11 Apr 2021.

Vancouver:

Jester BE. Examining the Relationship Between Impulsive Personalities and Neural Functioning in Cocaine-Addicted Participants. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2013. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/2152.5/1308.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jester BE. Examining the Relationship Between Impulsive Personalities and Neural Functioning in Cocaine-Addicted Participants. [Thesis]. University of Texas Southwestern Medical Center; 2013. Available from: http://hdl.handle.net/2152.5/1308

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Boston University

17. Culp, Jenna L. Cocaine use, treatment retention and opioid abstinence at six months in a coordinated primary care and substance abuse treatment clinic among opioid-dependent patients treated with buprenorphine.

Degree: MA, Medical Sciences, 2012, Boston University

URL: http://hdl.handle.net/2144/12336

► Cocaine use among opioid dependent persons is common, with an estimated 40 to 70% of those seeking treatment for opioid dependence, also using cocaine (Sullivan… (more)

▼ Cocaine use among opioid dependent persons is common, with an estimated 40 to 70% of those seeking treatment for opioid dependence, also using cocaine (Sullivan et al., 2011 ). The effects of cocaine use on treatment outcomes for those seeking medication assisted treatment (MAT) for opioid dependence are not well understood. Buprenorphine, prescribed under the brand name Suboxone, has recently emerged as a convenient, effective method of MAT. The Facilitated Access to Substance Abuse Treatment with Prevention And Treatment of HIV (FAST PATH) program at Boston Medical Center, is a research study to provide substance abuse treatment along with primary care and HIV risk-reduction counseling to those afflicted with these epidemics. The objective of this study was to determine the association of cocaine use with treatment retention and opioid abstinence at six months for patients receiving buprenorphine in the FAST PATH program. A prospective cohort study was conducted on 116 patients enrolled in the FAST PATH program through 02/01/2012. Assessments were conducted at baseline and six months to evaluate the association between baseline cocaine use and treatment retention as well as opioid abstinence at six months. Baseline cocaine use was measured by either any urine toxicology screen positive for cocaine prior to study enrollment or 30 day self-reported cocaine use on the initial assessment. Of the 116 participants, 39% were positive for cocaine use at baseline and 52% were HIV positive. Baseline cocaine use had no effect significant on treatment retention or opioid abstinence at six months. Among all the participant characteristics measured, there were no significant differences between the cocaine positive (n=45) and cocaine negative (n=71) groups. In adjusted analysis, age was the only covariate which was significant at predicting the odds of treatment retention or opioid abstinence with a 1.11 (p-value = 0.0003) and 1.08 (p-value = 0.02) greater odds of each, respectively. Although cocaine use did not affect the dependent variables, integrated substance abuse and primary care clinics utilizing buprenorphine are a rich area of future research. Specifically, subsequent studies should determine how varied groups of opioid dependent persons perform within this framework, and the underlying characteristics moderating their outcomes.

Subjects/Keywords: Opioid dependence; Cocaine; FAST PATH

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APA (6^th Edition):

Culp, J. L. (2012). Cocaine use, treatment retention and opioid abstinence at six months in a coordinated primary care and substance abuse treatment clinic among opioid-dependent patients treated with buprenorphine. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/12336

Chicago Manual of Style (16^th Edition):

Culp, Jenna L. “Cocaine use, treatment retention and opioid abstinence at six months in a coordinated primary care and substance abuse treatment clinic among opioid-dependent patients treated with buprenorphine.” 2012. Masters Thesis, Boston University. Accessed April 11, 2021. http://hdl.handle.net/2144/12336.

MLA Handbook (7^th Edition):

Culp, Jenna L. “Cocaine use, treatment retention and opioid abstinence at six months in a coordinated primary care and substance abuse treatment clinic among opioid-dependent patients treated with buprenorphine.” 2012. Web. 11 Apr 2021.

Vancouver:

Culp JL. Cocaine use, treatment retention and opioid abstinence at six months in a coordinated primary care and substance abuse treatment clinic among opioid-dependent patients treated with buprenorphine. [Internet] [Masters thesis]. Boston University; 2012. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/2144/12336.

Council of Science Editors:

Culp JL. Cocaine use, treatment retention and opioid abstinence at six months in a coordinated primary care and substance abuse treatment clinic among opioid-dependent patients treated with buprenorphine. [Masters Thesis]. Boston University; 2012. Available from: http://hdl.handle.net/2144/12336

18. Puig, Stéphanie. Etude intégrée des variations comportementales, neurochimiques et cellulaires de la cocaïne : Analyse des variations à court et à long terme : Importance du profil d’administration et anticipation de l’effet renforçant de la drogue : Integrated study of variations behavioral, neurochemical and cellular of the cocaine.

Degree: Docteur es, Neurosciences, 2012, Université Paris Descartes – Paris V

URL: http://www.theses.fr/2012PA05P620

►

La prise répétée de cocaïne entraine la mise en place d’une addiction durable. Cette maladie neuropsychiatrique est un problème de santé public majeur en France… (more)

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La prise répétée de cocaïne entraine la mise en place d’une addiction durable. Cette maladie neuropsychiatrique est un problème de santé public majeur en France et dans le monde. Les effets aigus de la cocaïne sont maintenant bien connus mais il est encore difficile d’établir un consensus des conséquences d’une administration répétée de ce psychostimulant au niveau central. En effet, les résultats rapportés dans la littérature actuelle présentent de nombreuses disparités. Nous pensons que cela pourrait être dû aux différences de protocole d’administration utilisés par chaque laboratoire. Nous émettons l’hypothèse que si à l’heure actuelle il n’existe pas de traitement efficace pour traiter les cocaïnomanes, c’est que les thérapies ne prennent pas en compte les différentes modifications neurobiologiques induites par les différents profils de consommation. Afin de tester cette hypothèse, nous avons comparé deux profils d’administration différents de cocaïne chez le rat. Nous nous sommes intéressés aux conséquences comportementales, neurochimiques et cellulaires après un sevrage court et un sevrage long. Nous avons mis en évidence que les adaptations comportementales (activité locomotrice et exploratoire), neurochimiques (dopamine extracellulaire) et cellulaires (récepteurs dopaminergiques) basales et en réponse à une dose de rappel, sont différentes selon le profil d’administration de cocaïne. Nous avons également mis en évidence une anticipation neurochimique dopaminergique et locomotrice, exactement à l’heure habituelle d’injection et qui varie selon le profil d’administration. Dans un deuxième temps, nous avons montré que le BDNF (Brain Derived Neurotrophic Factor), qui est une neurotrophine du système catécholaminergique, varie à la fois au niveau central et au niveau périphérique, de façon spécifique pour chaque profil d’administration de cocaïne. L’utilisation en clinique de ce biomarqueur périphérique (BDNF), permettrait d’évaluer les variations neurobiologiques centrales chez les patients cocaïnomanes et d’établir un traitement thérapeutique approprié à leur profil de consommation. L’ensemble des résultats obtenus au cours de cette thèse, ont permis de montrer que le profil d’administration a une grande importance sur les conséquences neurobiologiques de la cocaïne

Pas de résumé en anglais

Advisors/Committee Members: Noble, Florence (thesis director).

Subjects/Keywords: Cocaïne; Cocaine; 612.804 2

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APA (6^th Edition):

Puig, S. (2012). Etude intégrée des variations comportementales, neurochimiques et cellulaires de la cocaïne : Analyse des variations à court et à long terme : Importance du profil d’administration et anticipation de l’effet renforçant de la drogue : Integrated study of variations behavioral, neurochemical and cellular of the cocaine. (Doctoral Dissertation). Université Paris Descartes – Paris V. Retrieved from http://www.theses.fr/2012PA05P620

Chicago Manual of Style (16^th Edition):

Puig, Stéphanie. “Etude intégrée des variations comportementales, neurochimiques et cellulaires de la cocaïne : Analyse des variations à court et à long terme : Importance du profil d’administration et anticipation de l’effet renforçant de la drogue : Integrated study of variations behavioral, neurochemical and cellular of the cocaine.” 2012. Doctoral Dissertation, Université Paris Descartes – Paris V. Accessed April 11, 2021. http://www.theses.fr/2012PA05P620.

MLA Handbook (7^th Edition):

Puig, Stéphanie. “Etude intégrée des variations comportementales, neurochimiques et cellulaires de la cocaïne : Analyse des variations à court et à long terme : Importance du profil d’administration et anticipation de l’effet renforçant de la drogue : Integrated study of variations behavioral, neurochemical and cellular of the cocaine.” 2012. Web. 11 Apr 2021.

Vancouver:

Puig S. Etude intégrée des variations comportementales, neurochimiques et cellulaires de la cocaïne : Analyse des variations à court et à long terme : Importance du profil d’administration et anticipation de l’effet renforçant de la drogue : Integrated study of variations behavioral, neurochemical and cellular of the cocaine. [Internet] [Doctoral dissertation]. Université Paris Descartes – Paris V; 2012. [cited 2021 Apr 11]. Available from: http://www.theses.fr/2012PA05P620.

Council of Science Editors:

Puig S. Etude intégrée des variations comportementales, neurochimiques et cellulaires de la cocaïne : Analyse des variations à court et à long terme : Importance du profil d’administration et anticipation de l’effet renforçant de la drogue : Integrated study of variations behavioral, neurochemical and cellular of the cocaine. [Doctoral Dissertation]. Université Paris Descartes – Paris V; 2012. Available from: http://www.theses.fr/2012PA05P620

University of Florida

19. Howard, Leslie R. Proteomic Analysis of the Effects of Ceftriaxone on Cocaine Induced Mitochondrial Dysfunction in the Nucleus Accumbens.

Degree: MS, Psychology, 2018, University of Florida

URL: https://ufdc.ufl.edu/UFE0052328

► Cocaine self-administration followed by extinction leads to a decrease in basal extracellular glutamate in the NAc of the rat brain, likely due to downregulation of… (more)

Subjects/Keywords: ceftriaxone – cocaine – nac – proteomics

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APA (6^th Edition):

Howard, L. R. (2018). Proteomic Analysis of the Effects of Ceftriaxone on Cocaine Induced Mitochondrial Dysfunction in the Nucleus Accumbens. (Masters Thesis). University of Florida. Retrieved from https://ufdc.ufl.edu/UFE0052328

Chicago Manual of Style (16^th Edition):

Howard, Leslie R. “Proteomic Analysis of the Effects of Ceftriaxone on Cocaine Induced Mitochondrial Dysfunction in the Nucleus Accumbens.” 2018. Masters Thesis, University of Florida. Accessed April 11, 2021. https://ufdc.ufl.edu/UFE0052328.

MLA Handbook (7^th Edition):

Howard, Leslie R. “Proteomic Analysis of the Effects of Ceftriaxone on Cocaine Induced Mitochondrial Dysfunction in the Nucleus Accumbens.” 2018. Web. 11 Apr 2021.

Vancouver:

Howard LR. Proteomic Analysis of the Effects of Ceftriaxone on Cocaine Induced Mitochondrial Dysfunction in the Nucleus Accumbens. [Internet] [Masters thesis]. University of Florida; 2018. [cited 2021 Apr 11]. Available from: https://ufdc.ufl.edu/UFE0052328.

Council of Science Editors:

Howard LR. Proteomic Analysis of the Effects of Ceftriaxone on Cocaine Induced Mitochondrial Dysfunction in the Nucleus Accumbens. [Masters Thesis]. University of Florida; 2018. Available from: https://ufdc.ufl.edu/UFE0052328

University of Minnesota

20. McCall, Nora. G protein-gated potassium channels in ventral tegmental area dopamine neurons temper behavioral sensitivity to cocaine.

Degree: PhD, Neuroscience, 2019, University of Minnesota

URL: http://hdl.handle.net/11299/202436

► Drugs of abuse share the ability to enhance dopamine (DA) release in the mesocorticolimbic system. This increase in DA is thought to drive persistent adaptations… (more)

▼ Drugs of abuse share the ability to enhance dopamine (DA) release in the mesocorticolimbic system. This increase in DA is thought to drive persistent adaptations in the brain and behavior that contribute to the progression of addiction. One such adaptation is a cocaine exposure-induced suppression of G protein-dependent inhibitory signaling in DA neurons of the ventral tegmental area (VTA), a cell population important for reward-related behavior. This cocaine-induced adaptation involves the internalization of G protein-gated inwardly rectifying K+ (GIRK/Kir3) channels, a key contributor to inhibitory G protein pathways that normally temper DA neurotransmission in the mesocorticolimbic system. Dopamine 2 receptor (D2R) activation mediates this adaptation. While methamphetamine, another psychostimulant, can induce a similar adaptation in inhibitory G protein signaling, other drugs of abuse, i.e. morphine, are unable to induce a GIRK channel adaptation. Thus, inhibitory G protein signaling in VTA DA neurons could be important for tempering the behavioral response to cocaine, and could represent an inhibitory “barrier” to addiction. The goal of this thesis research is to understand the impact of GIRK channel activity signaling on behavioral sensitivity to cocaine. The work in this thesis tests the hypothesis that the strength of inhibitory G protein signaling in VTA DA neurons is inversely related to behavioral sensitivity to cocaine. This hypothesis predicts decreasing GIRK channel activity in DA neurons will increase behavioral sensitivity to cocaine. To test this, a genetic strategy was employed, to ablate GIRK channels in DA neurons using DATCre(+):Girk2fl/fl mice. The strength of two significant G protein receptor-dependent signaling dependent on GIRK channels were significantly reduced in a dopamine neuron-specific manner. DATCre(+):Girk2fl/fl mice displayed increased locomotor responding to both acute and repeated cocaine, as well as increased responding for, and intake of, cocaine in intravenous self-administration. The DATCre(+):Girk2fl/fl manipulation parallels the cocaine-induced suppression of GIRK-dependent signaling in VTA DA neurons, and suggests the GIRK channel in DA neurons temper behavioral sensitivity to cocaine. This hypothesis was further tested in a VTA-specific manner using a Cre-dependent viral approach, overexpressing GIRK channels with opposing functional roles. The overexpression of GIRK2 increased inhibitory G protein signaling and decreased cocaine-induced locomotion, while conversely, overexpression of GIRK3 decreased inhibitory G protein signaling and increased cocaine-induced locomotion. Overall, this supports the hypothesis GIRK channel activity in VTA DA neurons tempers behavioral sensitivity to drugs of abuse. In addition to addiction, VTA DA neurons have been implicated in negative affective behaviors, notably following stress. Interestingly, manipulating GIRK channel activity did not alter depression- and anxiety-related behavior, suggests that inhibitory signaling in VTA DA…

Subjects/Keywords: cocaine; dopamine; GIRK; VTA

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

McCall, N. (2019). G protein-gated potassium channels in ventral tegmental area dopamine neurons temper behavioral sensitivity to cocaine. (Doctoral Dissertation). University of Minnesota. Retrieved from http://hdl.handle.net/11299/202436

Chicago Manual of Style (16^th Edition):

McCall, Nora. “G protein-gated potassium channels in ventral tegmental area dopamine neurons temper behavioral sensitivity to cocaine.” 2019. Doctoral Dissertation, University of Minnesota. Accessed April 11, 2021. http://hdl.handle.net/11299/202436.

MLA Handbook (7^th Edition):

McCall, Nora. “G protein-gated potassium channels in ventral tegmental area dopamine neurons temper behavioral sensitivity to cocaine.” 2019. Web. 11 Apr 2021.

Vancouver:

McCall N. G protein-gated potassium channels in ventral tegmental area dopamine neurons temper behavioral sensitivity to cocaine. [Internet] [Doctoral dissertation]. University of Minnesota; 2019. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/11299/202436.

Council of Science Editors:

McCall N. G protein-gated potassium channels in ventral tegmental area dopamine neurons temper behavioral sensitivity to cocaine. [Doctoral Dissertation]. University of Minnesota; 2019. Available from: http://hdl.handle.net/11299/202436

Texas Tech University

21. Clark, Jonathon Cary. The effect of cocaine on murine peritoneal macrophages.

Degree: 1995, Texas Tech University

URL: http://hdl.handle.net/2346/18163

► In recent years, cocaine has had a resurgence in popularity in the United States (Adams and Durell, 1984; Katz, 1985). The increased use of cocaine… (more)

Subjects/Keywords: Macrophages; Cocaine

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APA (6^th Edition):

Clark, J. C. (1995). The effect of cocaine on murine peritoneal macrophages. (Thesis). Texas Tech University. Retrieved from http://hdl.handle.net/2346/18163

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Clark, Jonathon Cary. “The effect of cocaine on murine peritoneal macrophages.” 1995. Thesis, Texas Tech University. Accessed April 11, 2021. http://hdl.handle.net/2346/18163.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Clark, Jonathon Cary. “The effect of cocaine on murine peritoneal macrophages.” 1995. Web. 11 Apr 2021.

Vancouver:

Clark JC. The effect of cocaine on murine peritoneal macrophages. [Internet] [Thesis]. Texas Tech University; 1995. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/2346/18163.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Clark JC. The effect of cocaine on murine peritoneal macrophages. [Thesis]. Texas Tech University; 1995. Available from: http://hdl.handle.net/2346/18163

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of South Florida

22. Haire, Kambria. Elucidation of the Role of Poly(ADP-Ribose) Polymerase in Drug-Induced Toxicity.

Degree: 2015, University of South Florida

URL: https://scholarcommons.usf.edu/etd/5959

► Drug toxicity may cause liver injury, resulting in damage to cells and tissues. This damage can lead to cytotoxic events that may result in an… (more)

▼ Drug toxicity may cause liver injury, resulting in damage to cells and tissues. This damage can lead to cytotoxic events that may result in an activation of poly (ADP-ribose) polymerase (PARP). A study was conducted to determine if cocaine and acetaminophen toxicity lead to DNA damage and to the activation of the repair protein, PARP in the liver using the hepatotoxicants: cocaine and acetaminophen (APAP). A dose-response analysis for cocaine concluded that a dose as low as 20 mg/kg resulted in elevated ALT levels. A higher dose of 60 mg/kg was tested for analyses but resulted in severe hemorrhaging. The dose-response analyses for APAP resulted in no elevated liver enzyme levels for a 75 mg/kg and 150 mg/kg dose. A dose of 50 mg/kg for cocaine, and a dose of 300 mg/kg for APAP were used to analyze temporal trends for both toxicants. Both cocaine and APAP produced incremental increases in ALT at the 2 hour, 6 hour, 18 hour, and 24 hour time points, respectively. PARP activity analysis for cocaine measured the highest activity at the 2hr and 6hr time points. PARP analysis for acetaminophen measured gradual increases until the 18 hour time point where the highest level of PARP activity was measured. A PARP inhibition analysis was conducted with cocaine and (APAP) to understand the impact of a PARP inhibitor, 1,5-dihydroxyisoquinoline (DIQ), on PARP activity in the liver. A 50 mg/kg dose of cocaine or a 300 mg/kg dose of APAP was administered, followed by a 10 mg/kg dose of DIQ at 1) the time of initial toxicant dose (0 hour), or 2) 1 hour after initial toxicant dose (1hr). The PARP inhibition analysis for cocaine and APAP was conducted at 6 and 18 hours post initial dose, respectively, when the highest levels of PARP were observed. Inhibition analyses determined that ALT declined significantly when DIQ was administered immediately following the initial toxicant dose for both toxicants. DIQ administered 1 hr after initial toxicant dose resulted in slightly higher ALT than the 0 hr time point. Decreases in PARP activity were observed at the 0 hr time point, with slightly higher PARP levels observed at the 1 hr time point. Decreased PARP activity was observed following DIQ treatment with both, a concurrent drug treatment and treatment following drug administration. Cocaine and APAP treatment did not cause DNA fragmentation. A liver glutathione (GSH) analysis conducted for cocaine and APAP did not correlate with DIQ alteration of PARP activity. The mechanism of DIQ effects on drug-induced hepatotoxicity appears to be GSH independent. DIQ was effective in reducing drug-induced hepatotoxicity and preserving organ function.

Subjects/Keywords: PARP; Heptotoxicity; Cocaine; Acetaminophen; Toxicology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Haire, K. (2015). Elucidation of the Role of Poly(ADP-Ribose) Polymerase in Drug-Induced Toxicity. (Thesis). University of South Florida. Retrieved from https://scholarcommons.usf.edu/etd/5959

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Haire, Kambria. “Elucidation of the Role of Poly(ADP-Ribose) Polymerase in Drug-Induced Toxicity.” 2015. Thesis, University of South Florida. Accessed April 11, 2021. https://scholarcommons.usf.edu/etd/5959.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Haire, Kambria. “Elucidation of the Role of Poly(ADP-Ribose) Polymerase in Drug-Induced Toxicity.” 2015. Web. 11 Apr 2021.

Vancouver:

Haire K. Elucidation of the Role of Poly(ADP-Ribose) Polymerase in Drug-Induced Toxicity. [Internet] [Thesis]. University of South Florida; 2015. [cited 2021 Apr 11]. Available from: https://scholarcommons.usf.edu/etd/5959.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Haire K. Elucidation of the Role of Poly(ADP-Ribose) Polymerase in Drug-Induced Toxicity. [Thesis]. University of South Florida; 2015. Available from: https://scholarcommons.usf.edu/etd/5959

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas Tech University

23. Brown, Deanna Jo. The effects of cocaine on viral replication in immune cells.

Degree: 1996, Texas Tech University

URL: http://hdl.handle.net/2346/14961

► Previous studies have shown that cocaine is capable of altering a number of macrophage functions. The present study demonstrates that the incubation of murine peritoneal… (more)

Subjects/Keywords: Cocaine; Macrophages

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APA (6^th Edition):

Brown, D. J. (1996). The effects of cocaine on viral replication in immune cells. (Thesis). Texas Tech University. Retrieved from http://hdl.handle.net/2346/14961

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Brown, Deanna Jo. “The effects of cocaine on viral replication in immune cells.” 1996. Thesis, Texas Tech University. Accessed April 11, 2021. http://hdl.handle.net/2346/14961.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Brown, Deanna Jo. “The effects of cocaine on viral replication in immune cells.” 1996. Web. 11 Apr 2021.

Vancouver:

Brown DJ. The effects of cocaine on viral replication in immune cells. [Internet] [Thesis]. Texas Tech University; 1996. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/2346/14961.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Brown DJ. The effects of cocaine on viral replication in immune cells. [Thesis]. Texas Tech University; 1996. Available from: http://hdl.handle.net/2346/14961

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Georgia

24. Mathilakath Keralapurath, Madhusudhanan. Factors affecting the synaptic plasticity of hippocampus.

Degree: 2014, University of Georgia

URL: http://hdl.handle.net/10724/30539

► Involvement of the hippocampus in learning and memory is well known. Despite maintaining a uniform intrinsic circuitry throughout the structure, there are evidences for significant… (more)

▼ Involvement of the hippocampus in learning and memory is well known. Despite maintaining a uniform intrinsic circuitry throughout the structure, there are evidences for significant functional differences between the septal (dorsal) and temporal (ventral) sectors of hippocampus. Appreciation for the role of ventral hippocampus in the emotive and reward associated behaviors is on the rise. Behavioral and lesion studies in rodents have suggested that hippocampus plays an important role in drug reinstatement behaviors, although confirmatory molecular and electrophysiological evidences are lacking in this aspect. To study the effects of cocaine, we employed either the locomotor sensitization protocol where the drug was non-contingently administered by the experimenter, or we utilized the self-administration protocol where the rats were allowed to voluntarily administer drugs. Additionally, hippocampal feedback regulation of the hypothalamus-pituitary-adrenal axis is critical in the body’s response to stress. We investigated the effects of minor stressors such as novelty, handling and i.p. injections associated with a locomotor sensitization protocol on the hippocampal synaptic plasticity. We found that the minor, intermittent stressors associated with commonly employed behavioral protocols were sufficient to induce persistent stress-like effects. Cocaine, either experimenter administered or self-administered by the rats, specifically altered synaptic properties in the ventral hippocampus, albeit in different ways. Non-contingent cocaine exposures acted as metaplastic triggers and persistently enhanced the artificially induced LTP in the ventral hippocampus for at least 2 weeks after the last injection. In contrast, cocaine self-administration resulted in persistent enhancement of basal synaptic transmission in the ventral hippocampus, with both increases in excitatory glutamatergic activity and suppression of GABAergic inhibition being observed. Unlike in the non-contingently exposed groups, cocaine self-administration resulted in the suppression of LTP in the ventral hippocampus, suggesting a causal link between impaired learning and addicted states observed in the human subjects. Increased sensitivity of the ventral sector of the hippocampus to stress and drugs of abuse indicate its importance in the neuronal circuitry as a key intersection point where these co-morbidities of stress and drugs of abuse overlap.

Subjects/Keywords: hippocampus; dorsal; ventral; stress; cocaine

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APA (6^th Edition):

Mathilakath Keralapurath, M. (2014). Factors affecting the synaptic plasticity of hippocampus. (Thesis). University of Georgia. Retrieved from http://hdl.handle.net/10724/30539

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mathilakath Keralapurath, Madhusudhanan. “Factors affecting the synaptic plasticity of hippocampus.” 2014. Thesis, University of Georgia. Accessed April 11, 2021. http://hdl.handle.net/10724/30539.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mathilakath Keralapurath, Madhusudhanan. “Factors affecting the synaptic plasticity of hippocampus.” 2014. Web. 11 Apr 2021.

Vancouver:

Mathilakath Keralapurath M. Factors affecting the synaptic plasticity of hippocampus. [Internet] [Thesis]. University of Georgia; 2014. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/10724/30539.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mathilakath Keralapurath M. Factors affecting the synaptic plasticity of hippocampus. [Thesis]. University of Georgia; 2014. Available from: http://hdl.handle.net/10724/30539

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Rutgers University

25. Pantazis, Caroline B., 1990-. Lateral septum and lateral hypothalamus orexin neurons mediate motivation for cocaine through interactions with the mesolimbic dopamine system.

Degree: PhD, Addiction, 2019, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/60914/

►

Drug addiction is a disorder characterized by pathological motivation for drug. Our laboratory has recently developed a behavioral economics (BE) paradigm that uniquely assesses demand… (more)

▼

Drug addiction is a disorder characterized by pathological motivation for drug. Our laboratory has recently developed a behavioral economics (BE) paradigm that uniquely assesses demand for drugs of abuse. Animals’ individual lever-pressing data can be fitted to demand curves to determine two important measures of cocaine demand: baseline consumption (Q0) and motivation (α). As α is the slope of the demand curve, it inversely scales with motivation, such that animals with greater demand elasticity (α) have lower motivation for cocaine. Here, we utilized our BE paradigm with pharmacological, morpholino antisense, and retrograde tracing approaches and determined that lateral septum (LS) and lateral hypothalamus (LH) orexin neurons are important neuronal populations for cocaine demand elasticity (α). We demonstrate that inhibiting LS reduced motivation (increased demand elasticity; α) and that the benzodiazepine diazepam blocked this effect, pointing to opposing roles of the two manipulations on ventral tegmental area (VTA) dopamine signaling. The two manipulations were similarly found to be anxiolytic, indicating that changes in drug taking occurred independently of effects on anxiety. Similarly, we show that orexin signaling contributes to motivation for cocaine (α) and that the involvement of orexin in motivated drug taking is mediated primarily by orexin neurons in LH. Animals sacrificed after BE had greater expression of orexin neurons in LH, and unilateral knockdown of LH orexin cells attenuated motivation during BE. The number of spared LH orexin neurons predicted α value in antisense-infused animals and in animals sacrificed two weeks after BE testing. We then blocked orexin-1 receptor signaling in VTA using the oreceptor antagonist SB-334867 (SB) and found that intra-VTA SB reduced motivation. The effects of SB specifically occurred in animals trained and tested on BE with cues and removing cocaine-paired cues reduced SB efficacy. Finally, using retrograde tract tracing, we observed that a greater proportion of LH orexin neurons project to VTA than do other subregions of the orexin cell field. Collectively, these studies implicate two important neuronal populations in motivation for cocaine and indicate that both LS and LH orexin connections to the mesolimbic dopamine system mediate their effects on motivation.

Advisors/Committee Members: Aston-Jones, Gary (chair), School of Graduate Studies.

Subjects/Keywords: Neuroscience; Cocaine abuse – Prevention; Neuropharmacology

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APA (6^th Edition):

Pantazis, Caroline B., 1. (2019). Lateral septum and lateral hypothalamus orexin neurons mediate motivation for cocaine through interactions with the mesolimbic dopamine system. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/60914/

Chicago Manual of Style (16^th Edition):

Pantazis, Caroline B., 1990-. “Lateral septum and lateral hypothalamus orexin neurons mediate motivation for cocaine through interactions with the mesolimbic dopamine system.” 2019. Doctoral Dissertation, Rutgers University. Accessed April 11, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/60914/.

MLA Handbook (7^th Edition):

Pantazis, Caroline B., 1990-. “Lateral septum and lateral hypothalamus orexin neurons mediate motivation for cocaine through interactions with the mesolimbic dopamine system.” 2019. Web. 11 Apr 2021.

Vancouver:

Pantazis, Caroline B. 1. Lateral septum and lateral hypothalamus orexin neurons mediate motivation for cocaine through interactions with the mesolimbic dopamine system. [Internet] [Doctoral dissertation]. Rutgers University; 2019. [cited 2021 Apr 11]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/60914/.

Council of Science Editors:

Pantazis, Caroline B. 1. Lateral septum and lateral hypothalamus orexin neurons mediate motivation for cocaine through interactions with the mesolimbic dopamine system. [Doctoral Dissertation]. Rutgers University; 2019. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/60914/

Nelson Mandela Metropolitan University

26. Plumb, Sarah. The art of addiction : a phenomenological study of the lived experiences of cocaine dependents.

Degree: Faculty of Health Sciences, 2009, Nelson Mandela Metropolitan University

URL: http://hdl.handle.net/10948/902

► Addiction is a complex social phenomenon resulting from psychological and physiological dependence. The aim of the study was to create a clinical impression of the… (more)

Subjects/Keywords: Cocaine abuse; Cocaine – Social aspects; Drugs – Physiological effect

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Plumb, S. (2009). The art of addiction : a phenomenological study of the lived experiences of cocaine dependents. (Thesis). Nelson Mandela Metropolitan University. Retrieved from http://hdl.handle.net/10948/902

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Plumb, Sarah. “The art of addiction : a phenomenological study of the lived experiences of cocaine dependents.” 2009. Thesis, Nelson Mandela Metropolitan University. Accessed April 11, 2021. http://hdl.handle.net/10948/902.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Plumb, Sarah. “The art of addiction : a phenomenological study of the lived experiences of cocaine dependents.” 2009. Web. 11 Apr 2021.

Vancouver:

Plumb S. The art of addiction : a phenomenological study of the lived experiences of cocaine dependents. [Internet] [Thesis]. Nelson Mandela Metropolitan University; 2009. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/10948/902.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Plumb S. The art of addiction : a phenomenological study of the lived experiences of cocaine dependents. [Thesis]. Nelson Mandela Metropolitan University; 2009. Available from: http://hdl.handle.net/10948/902

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Texas Southwestern Medical Center

27. Carreira Franceschi, Maria Beatriz. Characterization of Histone Deacetylase 4 and Histone Deacetylase 5 in Cocaine-Related Behaviors.

Degree: 2016, University of Texas Southwestern Medical Center

URL: http://hdl.handle.net/2152.5/5304

► In recent years a focus on epigenetic mechanisms as mediators of cocaine-related behavioral, structural and functional plasticity has developed. One family of epigenetic molecules that… (more)

▼ In recent years a focus on epigenetic mechanisms as mediators of cocaine-related behavioral, structural and functional plasticity has developed. One family of epigenetic molecules that may underlie cocaine behavioral and functional changes is the histone deacetylase family that acts to mediate transcriptional repression. The class IIa subgroup of histone deacetylases is poised as an intracellular signal detector and effector by virtue of their ability to shuttle subcellularly in a dynamic and activity-dependent manner primarily driven by phosphorylation status of the protein at multiple residues. The overlying goal of this thesis was to two-faceted: to characterize the regulation of two class IIa members, HDAC4 and HDAC5, by cocaine-mediated signaling and to characterize the role of HDAC4 and HDAC5 in cocaine-associated behavioral plasticity. We report the regulation of phosphorylation and localization of HDAC4 and HDAC5 is in opposition. HDAC5 is dephosphorylated and accumulated in the nuclear compartment in response to cocaine, dopamine dependent signaling and cAMP activity. Meanwhile, we observe that HDAC4 is weakly dephosphorylated by cAMP activity in culture but weakly phosphorylated in vivo. These findings encouraged the analysis of function of these highly homologous class members. We assessed the function of HDAC4 and HDAC5 in the nucleus accumbens, a critical region for reward, by over-expressing wildtype and nuclear variants by targeted viral-mediated gene transfer. We report an attenuation of cocaine reward learning by nuclear HDAC5 but not wildtype or HDAC4 over-expression. We further analyzed the role of HDAC5 in self-administration behavior and report an effect of nuclear HDAC5, but not wildtype, on models of reinstatement of seeking, a preclinical model of relapse. These effects were observed in the absence of an effect on intake, sensitivity or motivation to self-administer. Because HDAC4 and HDAC5 bind nuclear transcriptional regulators to exert transcriptional repression of target genes we analyzed the dependence of nuclear HDAC5 on interacting with MEF2, a primary binding partners, and report that this interaction is likely required for modulating reinstatement of seeking but dispensable for cocaine reward. Taken together, these findings highlight the role of nuclear HDAC5 but not HDAC4 to limit cocaine reward and aspects of cocaine addiction-like behavior. Advisors/Committee Members: Self, David W., Cowan, Christopher W., Huber, Kimberly M., Rothenfluh, Adrian.

Subjects/Keywords: Cocaine; Cocaine-Related Disorders; Histone Deacetylases; Nucleus Accumbens; Reward; Self Administration

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APA (6^th Edition):

Carreira Franceschi, M. B. (2016). Characterization of Histone Deacetylase 4 and Histone Deacetylase 5 in Cocaine-Related Behaviors. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/5304

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Carreira Franceschi, Maria Beatriz. “Characterization of Histone Deacetylase 4 and Histone Deacetylase 5 in Cocaine-Related Behaviors.” 2016. Thesis, University of Texas Southwestern Medical Center. Accessed April 11, 2021. http://hdl.handle.net/2152.5/5304.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Carreira Franceschi, Maria Beatriz. “Characterization of Histone Deacetylase 4 and Histone Deacetylase 5 in Cocaine-Related Behaviors.” 2016. Web. 11 Apr 2021.

Vancouver:

Carreira Franceschi MB. Characterization of Histone Deacetylase 4 and Histone Deacetylase 5 in Cocaine-Related Behaviors. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2016. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/2152.5/5304.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Carreira Franceschi MB. Characterization of Histone Deacetylase 4 and Histone Deacetylase 5 in Cocaine-Related Behaviors. [Thesis]. University of Texas Southwestern Medical Center; 2016. Available from: http://hdl.handle.net/2152.5/5304

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Georgia Tech

28. Javanmard, Sahar. Synthesis and pharmacology of site-specific cocaine abuse treatment agents.

Degree: PhD, Chemistry, 2002, Georgia Tech

URL: http://hdl.handle.net/1853/30952

Subjects/Keywords: Cocaine habit Treatment; Cocaine Toxicology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Javanmard, S. (2002). Synthesis and pharmacology of site-specific cocaine abuse treatment agents. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/30952

Chicago Manual of Style (16^th Edition):

Javanmard, Sahar. “Synthesis and pharmacology of site-specific cocaine abuse treatment agents.” 2002. Doctoral Dissertation, Georgia Tech. Accessed April 11, 2021. http://hdl.handle.net/1853/30952.

MLA Handbook (7^th Edition):

Javanmard, Sahar. “Synthesis and pharmacology of site-specific cocaine abuse treatment agents.” 2002. Web. 11 Apr 2021.

Vancouver:

Javanmard S. Synthesis and pharmacology of site-specific cocaine abuse treatment agents. [Internet] [Doctoral dissertation]. Georgia Tech; 2002. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/1853/30952.

Council of Science Editors:

Javanmard S. Synthesis and pharmacology of site-specific cocaine abuse treatment agents. [Doctoral Dissertation]. Georgia Tech; 2002. Available from: http://hdl.handle.net/1853/30952

Temple University

29. Lamarre, Neil Stanley. Utilizing novel dose equivalence methodologies to examine cocaine's effects on the vasculature.

Degree: PhD, 2013, Temple University

URL: http://digital.library.temple.edu/u?/p245801coll10,221180

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Pharmacology

UTILIZING NOVEL DOSE EQUIVALENCE METHODOLOGIES TO EXAMINE COCAINE'S EFFECTS ON THE VASCULATURE Neil S. Lamarre Doctor of Philosophy Temple University School of Medicine, 2013… (more)

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Pharmacology

UTILIZING NOVEL DOSE EQUIVALENCE METHODOLOGIES TO EXAMINE COCAINE'S EFFECTS ON THE VASCULATURE Neil S. Lamarre Doctor of Philosophy Temple University School of Medicine, 2013 Doctoral Advisory Committee Chair: Ronald J. Tallarida, Ph.D. Cocaine abuse and addiction is a serious health problem, resulting in thousands of emergency room visits and deaths each year in the United States. It is particularly toxic to the cardiovascular system, including deleterious effects on the peripheral vasculature. These effects are not well understood, but evidence suggests chronic cocaine use may lead to endothelial dysfunction, thereby increasing relative risk of a number of other cardiovascular diseases including stroke, aneurysm, myocardial infarction, hypertension, etc. Data from our lab, and others, suggest that the presence of a functional endothelium has a dramatic effect on the contractility of the rat aorta that is agonist-specific. Attenuation of this endothelium-dependent vasodilatory component of agonist action is a primary feature of endothelial dysfunction. We have utilized dose equivalence theory to calculate the dose response relationship for the endothelium-dependent vasodilatory component of an agonist causing overt vasoconstriction. This component cannot be measured directly, but our novel methodology allows us to quantitate agonist-specific impairment of vasodilation, and describe it using the familiar parameters of the dose response curve. Another strength of this method, relative to currently used in vitro methods, is that it also avoids the confounding variable of a second agonist used to produce the initial vasoconstriction. To validate the methodology, a pilot study was performed examining the endothelial dysfunction in STZ-induced diabetic rats, as a positive control for endothelial dysfunction. Interestingly, this treatment showed impairment in the endothelium-dependent vasodilatory component of action of norepinephrine, but not of angiotensin-II. Thus, our initial hypothesis was confirmed - that disruption of the vasodilatory components of various agonists are independent, and that agonist-specific information may prove useful. Next, we employed our new methodology utilizing the rat aorta as our vascular model to test the hypothesis that chronic cocaine administration causes endothelial dysfunction. We first examined the endothelium-dependent vasodilation component of a number of physiologically important vasoconstrictors, and attempted to determine which vasodilatory mediators contributed to the effect. We found the endothelium to have a profound effect on the dose response curve to three important endogenous agonists. These data suggest that under conditions of endothelial dysfunction exaggerated vasoconstriction could occur, even within normal plasma concentration ranges of these vasoconstrictors, resulting in elevated blood pressure and further damage to the endothelium over time. No endothelial dysfunction was observed with this treatment paradigm, using our methodology or the standard…

Advisors/Committee Members: Tallarida, Ronald J.;, Ruggieri, Michael R., Heckman, James L., Parry, Tom Jay, Raffa, Robert B., McGonigle, Paul;.

Subjects/Keywords: Pharmacology;

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lamarre, N. S. (2013). Utilizing novel dose equivalence methodologies to examine cocaine's effects on the vasculature. (Doctoral Dissertation). Temple University. Retrieved from http://digital.library.temple.edu/u?/p245801coll10,221180

Chicago Manual of Style (16^th Edition):

Lamarre, Neil Stanley. “Utilizing novel dose equivalence methodologies to examine cocaine's effects on the vasculature.” 2013. Doctoral Dissertation, Temple University. Accessed April 11, 2021. http://digital.library.temple.edu/u?/p245801coll10,221180.

MLA Handbook (7^th Edition):

Lamarre, Neil Stanley. “Utilizing novel dose equivalence methodologies to examine cocaine's effects on the vasculature.” 2013. Web. 11 Apr 2021.

Vancouver:

Lamarre NS. Utilizing novel dose equivalence methodologies to examine cocaine's effects on the vasculature. [Internet] [Doctoral dissertation]. Temple University; 2013. [cited 2021 Apr 11]. Available from: http://digital.library.temple.edu/u?/p245801coll10,221180.

Council of Science Editors:

Lamarre NS. Utilizing novel dose equivalence methodologies to examine cocaine's effects on the vasculature. [Doctoral Dissertation]. Temple University; 2013. Available from: http://digital.library.temple.edu/u?/p245801coll10,221180

Temple University

30. Kim, Jae Kyun. CXCL12/CXCR4 signaling in mesocorticolimbic reward pathways: relevance to cocaine reinforcement and relapse.

Degree: PhD, 2016, Temple University

URL: http://digital.library.temple.edu/u?/p245801coll10,399036

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Pharmacology

The role of chemokines as chemotactic cytokines and their functions in the immune system and related pathologies are well defined. Recently, strong evidence supporting… (more)

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Pharmacology

The role of chemokines as chemotactic cytokines and their functions in the immune system and related pathologies are well defined. Recently, strong evidence supporting the hypothesis that chemokines can act as modulators of neuronal activity and influence neurotransmission has been reported. The chemokine CXCL12 is constitutively expressed in adult brain and expression of CXCL12 and its cognate receptor CXCR4 have been reported in regions of rat brain that construct dopamine (DA) and glutamate (GLU) pathways such as ventral tegmental area (VTA), substantia nigra (SN), and nucleus accumbens (NAc). In the central nervous system (CNS), activation of CXCR4 on dopaminergic neurons and astrocytes initiate cascade of events that leads to DA and GLU release and influence synaptic transmission. In vivo, intracerebroventricular (ICV) CXCL12 has been shown to potentiate cocaine-induced locomotor activity. Based on these evidences, the studies, as outlined in this dissertation, aimed to expand understanding of how CXCL12/CXCR4 interaction can affect cocaine-induced behavior and reinforcement, with special focus on mechanisms involving GLU. We first evaluated involvement of CXCR4 activation by CXCL12 on cocaine-induced locomotor activity using a selective CXCR4 antagonist AMD3100. Results demonstrated that AMD3100 (5, 10 mg/kg, IP) pretreatment dose-dependently attenuated cocaine-induced locomotor activity without affecting the baseline activity. Thereafter, effects of AMD3100 on cocaine’s reinforcing efficacy were tested using a biased conditioned place preference (CPP) paradigm. In all CPP experiments, saline pretreated controls established a significant preference for the cocaine-paired context following four pairings with cocaine (10 mg/kg, IP). Rats pretreated with 2.5 and 5 mg/kg AMD3100 prior to each pairing session showed significantly lower preference for the cocaine-paired side, whereas rats pretreated with 1 mg/kg AMD3100 showed similar preference for the cocaine-paired side as the saline controls when tested in the absence of the drug. Rats pretreated with AMD3100 (5 mg/kg, IP) just once prior to testing showed significantly lower preference for the cocaine-paired side. These results demonstrate that CXCR4 antagonism reduces development and expression of cocaine-induced CPP. Intravenous cocaine self-administration (SA) was performed to examine the effects of AMD3100 on the acquisition of cocaine-taking behavior and reinstatement to cocaine-seeking. Acquisition of cocaine SA was studied using three doses of cocaine (0.375, 0.5, 0.75 mg/kg/infusion) on a fixed-ratio 1 (FR-1) schedule of reinforcement. Two doses of AMD3100 (5, 10 mg/kg, IP) were tested. In all SA experiments, saline pretreated controls readily acquired cocaine self-administration. The lower and higher AMD3100 decreased the number of reinforcers earned during the two hour sessions compared to saline controls when tested against acquisition of 0.375 and 0.5 mg/kg/infusion cocaine. However, when tested against the 0.75 mg/kg/infusion…

Advisors/Committee Members: Rawls, Scott M;, Ashby, Barrie, Unterwald, Ellen M, Eisenstein, Toby K, Ramirez, Servio H, Walker, Ellen A;.

Subjects/Keywords: Pharmacology;

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kim, J. K. (2016). CXCL12/CXCR4 signaling in mesocorticolimbic reward pathways: relevance to cocaine reinforcement and relapse. (Doctoral Dissertation). Temple University. Retrieved from http://digital.library.temple.edu/u?/p245801coll10,399036

Chicago Manual of Style (16^th Edition):

Kim, Jae Kyun. “CXCL12/CXCR4 signaling in mesocorticolimbic reward pathways: relevance to cocaine reinforcement and relapse.” 2016. Doctoral Dissertation, Temple University. Accessed April 11, 2021. http://digital.library.temple.edu/u?/p245801coll10,399036.

MLA Handbook (7^th Edition):

Kim, Jae Kyun. “CXCL12/CXCR4 signaling in mesocorticolimbic reward pathways: relevance to cocaine reinforcement and relapse.” 2016. Web. 11 Apr 2021.

Vancouver:

Kim JK. CXCL12/CXCR4 signaling in mesocorticolimbic reward pathways: relevance to cocaine reinforcement and relapse. [Internet] [Doctoral dissertation]. Temple University; 2016. [cited 2021 Apr 11]. Available from: http://digital.library.temple.edu/u?/p245801coll10,399036.

Council of Science Editors:

Kim JK. CXCL12/CXCR4 signaling in mesocorticolimbic reward pathways: relevance to cocaine reinforcement and relapse. [Doctoral Dissertation]. Temple University; 2016. Available from: http://digital.library.temple.edu/u?/p245801coll10,399036

Open Access Theses and Dissertations