subject:(classical conditioning)

Vanderbilt University

1. Jiang, Hui. Drosophila Automated Olfactory Training and Testing System for Associative Learning.

Degree: MS, Electrical Engineering, 2015, Vanderbilt University

► This thesis demonstrates the feasibility of designing and building a Drosophila automated training and testing system for Pavlovian classical associative learning/memory analyses using inexpensive hardware… (more)

Subjects/Keywords: Pavlovian classical conditioning; automation; learning; Drosophila; memory

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Jiang, H. (2015). Drosophila Automated Olfactory Training and Testing System for Associative Learning. (Thesis). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/10420

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jiang, Hui. “Drosophila Automated Olfactory Training and Testing System for Associative Learning.” 2015. Thesis, Vanderbilt University. Accessed April 16, 2021. http://hdl.handle.net/1803/10420.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jiang, Hui. “Drosophila Automated Olfactory Training and Testing System for Associative Learning.” 2015. Web. 16 Apr 2021.

Vancouver:

Jiang H. Drosophila Automated Olfactory Training and Testing System for Associative Learning. [Internet] [Thesis]. Vanderbilt University; 2015. [cited 2021 Apr 16]. Available from: http://hdl.handle.net/1803/10420.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jiang H. Drosophila Automated Olfactory Training and Testing System for Associative Learning. [Thesis]. Vanderbilt University; 2015. Available from: http://hdl.handle.net/1803/10420

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Central Connecticut State University

2. Constantinou, Savvas James, 1990-. Classical Conditioning in Dugesia japonica : Effects of Octopamine on Memory Formation and Retention.

Degree: Department of Biomolecular Sciences, 2014, Central Connecticut State University

URL: http://content.library.ccsu.edu/u?/ccsutheses,1978

►

In classical conditioning, an organism is given pairings of an unconditioned stimulus (US) with a neutral conditioned stimulus (CS). With repetition the organism learns and… (more)

▼

In classical conditioning, an organism is given pairings of an unconditioned stimulus (US) with a neutral conditioned stimulus (CS). With repetition the organism learns and begins to respond to the conditioned stimulus in the same manner as the unconditioned stimulus. The ability to learn in planarian flatworms has been studied and the source of argument for over fifty years. One of the aims of this study was to determine if Dugesia japonica, a species of planaria, can learn. This study demonstrated that D. japonica initially show an ambient red light bias over ambient blue light, but are able to learn through pairing cathodal shock (US) with red light (CS) and in later testing show aversion to red light. Each planaria received 10 training sessions consisting of 12 pairings of red light/cathodal shock over the course of 5 days, with 2 training sessions per day. Using this training regimen, the learned behavior persists for up to 7 days. Octopamine (OA) is a neurotransmitter that is used as a neuromodulator of behavior and memory in some invertebrates. The role of OA in punishment pathways has recently been investigated in Apis mellifera and shown to play some role in inhibition of memory formation. Planaria have been used as a model organism for drug studies, both pharmacological agents as well as recreational drugs. The second major aim of these experiments was to determine the role OA plays in memory formation and retention in the useful planarian model organism. By exposing D. japonica to OA prior to each training session, the effects of excess OA could be examined. The planaria trained with excess OA did not form memory of the conditioning, as even after 7 days no aversion to red light was recorded. The ability to successfully train D. japonica, combined with the behavioral effects of OA, makes D. japonica a prime target for future memory/drug studies.

"Submitted in Partial Fulfillment of the Requirements for the Degree of Master of Arts in Biomolecular Sciences."; Thesis Advisor: Betsy Dobbs-McAuliffe.; M.A.,Central Connecticut State University,,2014.;

Advisors/Committee Members: Dobbs-McAuliffe, Betsy.

Subjects/Keywords: Dugesia.; Planaria.; Biogenic amines.; Classical conditioning.; Memory.

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APA (6^th Edition):

Constantinou, Savvas James, 1. (2014). Classical Conditioning in Dugesia japonica : Effects of Octopamine on Memory Formation and Retention. (Thesis). Central Connecticut State University. Retrieved from http://content.library.ccsu.edu/u?/ccsutheses,1978

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Constantinou, Savvas James, 1990-. “Classical Conditioning in Dugesia japonica : Effects of Octopamine on Memory Formation and Retention.” 2014. Thesis, Central Connecticut State University. Accessed April 16, 2021. http://content.library.ccsu.edu/u?/ccsutheses,1978.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Constantinou, Savvas James, 1990-. “Classical Conditioning in Dugesia japonica : Effects of Octopamine on Memory Formation and Retention.” 2014. Web. 16 Apr 2021.

Vancouver:

Constantinou, Savvas James 1. Classical Conditioning in Dugesia japonica : Effects of Octopamine on Memory Formation and Retention. [Internet] [Thesis]. Central Connecticut State University; 2014. [cited 2021 Apr 16]. Available from: http://content.library.ccsu.edu/u?/ccsutheses,1978.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Constantinou, Savvas James 1. Classical Conditioning in Dugesia japonica : Effects of Octopamine on Memory Formation and Retention. [Thesis]. Central Connecticut State University; 2014. Available from: http://content.library.ccsu.edu/u?/ccsutheses,1978

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Simon Fraser University

3. May, Thomas S. An investigation of classical odor conditioning in humans.

Degree: 1988, Simon Fraser University

URL: http://summit.sfu.ca/item/5352

Subjects/Keywords: Odors.; Classical conditioning.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

May, T. S. (1988). An investigation of classical odor conditioning in humans. (Thesis). Simon Fraser University. Retrieved from http://summit.sfu.ca/item/5352

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

May, Thomas S. “An investigation of classical odor conditioning in humans.” 1988. Thesis, Simon Fraser University. Accessed April 16, 2021. http://summit.sfu.ca/item/5352.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

May, Thomas S. “An investigation of classical odor conditioning in humans.” 1988. Web. 16 Apr 2021.

Vancouver:

May TS. An investigation of classical odor conditioning in humans. [Internet] [Thesis]. Simon Fraser University; 1988. [cited 2021 Apr 16]. Available from: http://summit.sfu.ca/item/5352.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

May TS. An investigation of classical odor conditioning in humans. [Thesis]. Simon Fraser University; 1988. Available from: http://summit.sfu.ca/item/5352

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Southern California

4. Singh, Kulwinder. Classically conditioned responses to food cues among obese and normal weight individuals: conditioning as an explanatory mechanism for excessive eating.

Degree: PhD, Psychology, 2014, University of Southern California

URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/434361/rec/1376

► As prevalence rates of obesity greatly increase in response to changing societal and environmental landscapes, it has become clear that genetic influences cannot solely account… (more)

▼ As prevalence rates of obesity greatly increase in response to changing societal and environmental landscapes, it has become clear that genetic influences cannot solely account for recent global surges in weight. One possible mechanism that has been proposed to contribute to the powerful effects of the environment on eating is associative learning. 121 obese, overweight, and normal‐weight students participated in a differential conditioning experiment using food cues as conditioned stimuli (CSs) and a sip of chocolate milkshake combined with a picture of an appetizing chocolate snack as unconditioned stimuli (UCS). Skin conductance and heart rate interbeat‐intervals were utilized as measures of autonomic conditioning, and self‐report valence changes and affective priming were used as measures of evaluative conditioning. It was hypothesized that obese participants would show greater responses to the UCS and stronger conditioning to food cues compared to normal‐weight participants. It was also hypothesized that autonomic conditioning would predict differential eating only for obese participants during a bogus taste test task. Results demonstrated that participants in the obese group had larger magnitude and more frequent responses to the UCS than did normal‐weight participants. For autonomic conditioning, only normal‐weight participants who were sated showed autonomic conditioning. For evaluative conditioning, obese and normal‐weight participants’ demonstrated conditioning based on the self‐report valence ratings but not on the affective priming task. Finally, autonomic conditioning predicted differential eating during the taste test only for obese participants who were food deprived. This association was non‐significant, albeit positive for normal‐weight participants who were food‐deprived. These results suggest that processes of Pavlovian classical conditioning may contribute to short‐-term increases in caloric consumption. However, additional steps which are further elaborated upon, must be taken to determine whether processes of classical conditioning may be a mechanism for weight gain and obesity. Advisors/Committee Members: Dawson, Michael Edward (Committee Chair), Schell, Anne M. (Committee Member), Shen, Biing-Jiun (Committee Member), Bob Knight (Committee Member), Monterosso, John R. (Committee Member), Brekke, John S. (Committee Member).

Subjects/Keywords: classical conditioning; differential autonomic conditioning; appetitive condtioning; food cues; obesity

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APA (6^th Edition):

Singh, K. (2014). Classically conditioned responses to food cues among obese and normal weight individuals: conditioning as an explanatory mechanism for excessive eating. (Doctoral Dissertation). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/434361/rec/1376

Chicago Manual of Style (16^th Edition):

Singh, Kulwinder. “Classically conditioned responses to food cues among obese and normal weight individuals: conditioning as an explanatory mechanism for excessive eating.” 2014. Doctoral Dissertation, University of Southern California. Accessed April 16, 2021. http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/434361/rec/1376.

MLA Handbook (7^th Edition):

Singh, Kulwinder. “Classically conditioned responses to food cues among obese and normal weight individuals: conditioning as an explanatory mechanism for excessive eating.” 2014. Web. 16 Apr 2021.

Vancouver:

Singh K. Classically conditioned responses to food cues among obese and normal weight individuals: conditioning as an explanatory mechanism for excessive eating. [Internet] [Doctoral dissertation]. University of Southern California; 2014. [cited 2021 Apr 16]. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/434361/rec/1376.

Council of Science Editors:

Singh K. Classically conditioned responses to food cues among obese and normal weight individuals: conditioning as an explanatory mechanism for excessive eating. [Doctoral Dissertation]. University of Southern California; 2014. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/434361/rec/1376

University of Maryland

5. Hong, Melanie. FEAR CONDITIONING ACROSS DEVELOPMENT: AN EXAMINATION OF FEAR ACQUISITION, EXTINCTION, AND GENERALIZATION IN 5-TO-10 YEAR OLD CHILDREN.

Degree: Human Development, 2013, University of Maryland

URL: http://hdl.handle.net/1903/14962

► The acquisition and extinction of fear is widely studied using fear conditioning (FC) paradigms. Few studies, however, have examined how fear learning emerges across development.… (more)

Subjects/Keywords: Developmental psychology; Physiological psychology; Classical conditioning; development; fear conditioning; skin conductance

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hong, M. (2013). FEAR CONDITIONING ACROSS DEVELOPMENT: AN EXAMINATION OF FEAR ACQUISITION, EXTINCTION, AND GENERALIZATION IN 5-TO-10 YEAR OLD CHILDREN. (Thesis). University of Maryland. Retrieved from http://hdl.handle.net/1903/14962

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hong, Melanie. “FEAR CONDITIONING ACROSS DEVELOPMENT: AN EXAMINATION OF FEAR ACQUISITION, EXTINCTION, AND GENERALIZATION IN 5-TO-10 YEAR OLD CHILDREN.” 2013. Thesis, University of Maryland. Accessed April 16, 2021. http://hdl.handle.net/1903/14962.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hong, Melanie. “FEAR CONDITIONING ACROSS DEVELOPMENT: AN EXAMINATION OF FEAR ACQUISITION, EXTINCTION, AND GENERALIZATION IN 5-TO-10 YEAR OLD CHILDREN.” 2013. Web. 16 Apr 2021.

Vancouver:

Hong M. FEAR CONDITIONING ACROSS DEVELOPMENT: AN EXAMINATION OF FEAR ACQUISITION, EXTINCTION, AND GENERALIZATION IN 5-TO-10 YEAR OLD CHILDREN. [Internet] [Thesis]. University of Maryland; 2013. [cited 2021 Apr 16]. Available from: http://hdl.handle.net/1903/14962.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hong M. FEAR CONDITIONING ACROSS DEVELOPMENT: AN EXAMINATION OF FEAR ACQUISITION, EXTINCTION, AND GENERALIZATION IN 5-TO-10 YEAR OLD CHILDREN. [Thesis]. University of Maryland; 2013. Available from: http://hdl.handle.net/1903/14962

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Cambridge

6. Curtis, Jack. Higher Order Conditioning of the Eyeblink Reflex.

Degree: PhD, 2019, University of Cambridge

URL: https://www.repository.cam.ac.uk/handle/1810/296917

► Classical conditioning of the eyeblink response is a well-established model of cerebellar-dependent associative motor learning. In this paradigm an initially neutral conditioned stimulus (CS -… (more)

▼ Classical conditioning of the eyeblink response is a well-established model of cerebellar-dependent associative motor learning. In this paradigm an initially neutral conditioned stimulus (CS - e.g. an auditory tone or light) that elicits no response is paired with an aversive unconditioned stimulus (US -e.g. an air puff to the eye ) that elicits an innate reflex blink response. A CS paired with the US at a fixed latency comes to elicit a predictive blink, if the CS begins sufficiently in advance of the US. A predictive blink is such that eyelid closure is maximal at the time of expected air puff delivery. Physical and pharmacological manipulation experiments have determined that this behaviour is dependent on the cerebellum, and theoretical accounts based on the structure of the cerebellum have proposed that it represents a mechanism for this type of learning (Marr, 1969; Albus, 1971). The cerebellum has two distinct afferent pathways. The first are the mossy fibres which have diverse origins from various nuclei, including sensory structures. The second pathway is that of the climbing fibres that originate from the inferior olivary nuclei. In Marr’s proposal, the climbing fibres represent instructive signals for plasticity, and the mossy fibres carry "context" information on which plasticity operates so that the contextual signals can activate learned movements. Studies in the eyeblink paradigm have confirmed that the climbing fibre activity is correlated with the US and that they encode error signals. Unexp ected aversive stimuli cause an increase in activity of climbing fibres, whereas the absence of a predicted aversive stimulus causes a decrease in the activity. Recent evidence has revealed that after training the climbing fibres become responsive to the conditioned stimulus, firing shortly after its onset. This suggests that the conditioned stimulus now has a prediction error value and could itself become a conditioned reinforcer. To test this experiments were devised in both rabbit and human subjects using second-order conditioning schedules, where conventional pairings of a CS1 and the US were interleaved with pairings of a different CS2 and the CS1 (but no US). Consistent results were obtained from both sets of experiments: some subjects learned to respond to the CS2, but more weakly than to the CS1. Strikingly the responses to the CS2 were more closely tied to the onset of CS1 (the time at which climbing fibres respond after training) rather than to the time of expected US. These findings confirm that the CS1 can become a conditioned reinforcer, but have implications for the prevailing view that eyeblink conditioning as a paradigm is primarily about the timing of the response. The relevance of the experimental eyeblink paradigms to natural behaviour is discussed.

Subjects/Keywords: Neuroscience; Behavioural; Classical Conditioning; Eyeblink Reflex; Higher Order; Second Order; Cerebellum; Motor Conditioning

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Curtis, J. (2019). Higher Order Conditioning of the Eyeblink Reflex. (Doctoral Dissertation). University of Cambridge. Retrieved from https://www.repository.cam.ac.uk/handle/1810/296917

Chicago Manual of Style (16^th Edition):

Curtis, Jack. “Higher Order Conditioning of the Eyeblink Reflex.” 2019. Doctoral Dissertation, University of Cambridge. Accessed April 16, 2021. https://www.repository.cam.ac.uk/handle/1810/296917.

MLA Handbook (7^th Edition):

Curtis, Jack. “Higher Order Conditioning of the Eyeblink Reflex.” 2019. Web. 16 Apr 2021.

Vancouver:

Curtis J. Higher Order Conditioning of the Eyeblink Reflex. [Internet] [Doctoral dissertation]. University of Cambridge; 2019. [cited 2021 Apr 16]. Available from: https://www.repository.cam.ac.uk/handle/1810/296917.

Council of Science Editors:

Curtis J. Higher Order Conditioning of the Eyeblink Reflex. [Doctoral Dissertation]. University of Cambridge; 2019. Available from: https://www.repository.cam.ac.uk/handle/1810/296917

7. Curtis, Jack. Higher order conditioning of the eyeblink reflex.

Degree: PhD, 2019, University of Cambridge

URL: https://doi.org/10.17863/CAM.43958 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.787771

► Classical conditioning of the eyeblink response is a well-established model of cerebellar-dependent associative motor learning. In this paradigm an initially neutral conditioned stimulus (CS -… (more)

▼ Classical conditioning of the eyeblink response is a well-established model of cerebellar-dependent associative motor learning. In this paradigm an initially neutral conditioned stimulus (CS - e.g. an auditory tone or light) that elicits no response is paired with an aversive unconditioned stimulus (US -e.g. an air puff to the eye ) that elicits an innate reflex blink response. A CS paired with the US at a fixed latency comes to elicit a predictive blink, if the CS begins sufficiently in advance of the US. A predictive blink is such that eyelid closure is maximal at the time of expected air puff delivery. Physical and pharmacological manipulation experiments have determined that this behaviour is dependent on the cerebellum, and theoretical accounts based on the structure of the cerebellum have proposed that it represents a mechanism for this type of learning (Marr, 1969; Albus, 1971). The cerebellum has two distinct afferent pathways. The first are the mossy fibres which have diverse origins from various nuclei, including sensory structures. The second pathway is that of the climbing fibres that originate from the inferior olivary nuclei. In Marr's proposal, the climbing fibres represent instructive signals for plasticity, and the mossy fibres carry "context" information on which plasticity operates so that the contextual signals can activate learned movements. Studies in the eyeblink paradigm have confirmed that the climbing fibre activity is correlated with the US and that they encode error signals. Unexp ected aversive stimuli cause an increase in activity of climbing fibres, whereas the absence of a predicted aversive stimulus causes a decrease in the activity. Recent evidence has revealed that after training the climbing fibres become responsive to the conditioned stimulus, firing shortly after its onset. This suggests that the conditioned stimulus now has a prediction error value and could itself become a conditioned reinforcer. To test this experiments were devised in both rabbit and human subjects using second-order conditioning schedules, where conventional pairings of a CS1 and the US were interleaved with pairings of a different CS2 and the CS1 (but no US). Consistent results were obtained from both sets of experiments: some subjects learned to respond to the CS2, but more weakly than to the CS1. Strikingly the responses to the CS2 were more closely tied to the onset of CS1 (the time at which climbing fibres respond after training) rather than to the time of expected US. These findings confirm that the CS1 can become a conditioned reinforcer, but have implications for the prevailing view that eyeblink conditioning as a paradigm is primarily about the timing of the response. The relevance of the experimental eyeblink paradigms to natural behaviour is discussed.

Subjects/Keywords: Neuroscience; Behavioural; Classical Conditioning; Eyeblink Reflex; Higher Order; Second Order; Cerebellum; Motor Conditioning

11 more images…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Curtis, J. (2019). Higher order conditioning of the eyeblink reflex. (Doctoral Dissertation). University of Cambridge. Retrieved from https://doi.org/10.17863/CAM.43958 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.787771

Chicago Manual of Style (16^th Edition):

Curtis, Jack. “Higher order conditioning of the eyeblink reflex.” 2019. Doctoral Dissertation, University of Cambridge. Accessed April 16, 2021. https://doi.org/10.17863/CAM.43958 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.787771.

MLA Handbook (7^th Edition):

Curtis, Jack. “Higher order conditioning of the eyeblink reflex.” 2019. Web. 16 Apr 2021.

Vancouver:

Curtis J. Higher order conditioning of the eyeblink reflex. [Internet] [Doctoral dissertation]. University of Cambridge; 2019. [cited 2021 Apr 16]. Available from: https://doi.org/10.17863/CAM.43958 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.787771.

Council of Science Editors:

Curtis J. Higher order conditioning of the eyeblink reflex. [Doctoral Dissertation]. University of Cambridge; 2019. Available from: https://doi.org/10.17863/CAM.43958 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.787771

8. Michel, Sergio B. (Sergio Barboza). Allocation of Attention: Effects on Classical Conditioning.

Degree: 1984, North Texas State University

URL: https://digital.library.unt.edu/ark:/67531/metadc331969/

► According to Deikman (1966), meditation (defined as a training to sustain attention) has a deautomatizing effect. This ascertion was utilized in the present study as… (more)

Subjects/Keywords: meditation; classical conditioning; attention span; Attention.; Classical conditioning.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Michel, S. B. (. B. (1984). Allocation of Attention: Effects on Classical Conditioning. (Thesis). North Texas State University. Retrieved from https://digital.library.unt.edu/ark:/67531/metadc331969/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Michel, Sergio B (Sergio Barboza). “Allocation of Attention: Effects on Classical Conditioning.” 1984. Thesis, North Texas State University. Accessed April 16, 2021. https://digital.library.unt.edu/ark:/67531/metadc331969/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Michel, Sergio B (Sergio Barboza). “Allocation of Attention: Effects on Classical Conditioning.” 1984. Web. 16 Apr 2021.

Vancouver:

Michel SB(B. Allocation of Attention: Effects on Classical Conditioning. [Internet] [Thesis]. North Texas State University; 1984. [cited 2021 Apr 16]. Available from: https://digital.library.unt.edu/ark:/67531/metadc331969/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Michel SB(B. Allocation of Attention: Effects on Classical Conditioning. [Thesis]. North Texas State University; 1984. Available from: https://digital.library.unt.edu/ark:/67531/metadc331969/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

9. Lin, Heng-yu. A Computational Model of Emotion Based on Biosystem.

Degree: Master, Information Management, 2014, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0810114-151710

► Robots began to appear in a variety of different tasks with the development of robot industrial in recent years, in particular the tasks have close… (more)

Subjects/Keywords: reinforcement learning; classical conditioning; emotion; computational; artificial neural network

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lin, H. (2014). A Computational Model of Emotion Based on Biosystem. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0810114-151710

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lin, Heng-yu. “A Computational Model of Emotion Based on Biosystem.” 2014. Thesis, NSYSU. Accessed April 16, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0810114-151710.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lin, Heng-yu. “A Computational Model of Emotion Based on Biosystem.” 2014. Web. 16 Apr 2021.

Vancouver:

Lin H. A Computational Model of Emotion Based on Biosystem. [Internet] [Thesis]. NSYSU; 2014. [cited 2021 Apr 16]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0810114-151710.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lin H. A Computational Model of Emotion Based on Biosystem. [Thesis]. NSYSU; 2014. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0810114-151710

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

10. Harris, Glenda C. Locus coeruleus involvement in the development of classically conditioned bradycardia.

Degree: PhD, 1989, Oregon Health Sciences University

URL: doi:10.6083/M4N29V3H ; http://digitalcommons.ohsu.edu/etd/1899

Subjects/Keywords: Conditioning, Classical; Locus Coeruleus; Norepinephrine

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Harris, G. C. (1989). Locus coeruleus involvement in the development of classically conditioned bradycardia. (Doctoral Dissertation). Oregon Health Sciences University. Retrieved from doi:10.6083/M4N29V3H ; http://digitalcommons.ohsu.edu/etd/1899

Chicago Manual of Style (16^th Edition):

Harris, Glenda C. “Locus coeruleus involvement in the development of classically conditioned bradycardia.” 1989. Doctoral Dissertation, Oregon Health Sciences University. Accessed April 16, 2021. doi:10.6083/M4N29V3H ; http://digitalcommons.ohsu.edu/etd/1899.

MLA Handbook (7^th Edition):

Harris, Glenda C. “Locus coeruleus involvement in the development of classically conditioned bradycardia.” 1989. Web. 16 Apr 2021.

Vancouver:

Harris GC. Locus coeruleus involvement in the development of classically conditioned bradycardia. [Internet] [Doctoral dissertation]. Oregon Health Sciences University; 1989. [cited 2021 Apr 16]. Available from: doi:10.6083/M4N29V3H ; http://digitalcommons.ohsu.edu/etd/1899.

Council of Science Editors:

Harris GC. Locus coeruleus involvement in the development of classically conditioned bradycardia. [Doctoral Dissertation]. Oregon Health Sciences University; 1989. Available from: doi:10.6083/M4N29V3H ; http://digitalcommons.ohsu.edu/etd/1899

UCLA

11. Reeves, Alexander Reeves. A Mechanism for Extinction of Classically Conditioned Forelimb Movement in Mice.

Degree: Neuroscience, 2016, UCLA

URL: http://www.escholarship.org/uc/item/7bc5m21n

► The cerebellum has long been hypothesized to be involved in the storage and expression of motor memories. Work presented in this thesis demonstrates that optogenetically… (more)

Subjects/Keywords: Neurosciences; Cerebellum; Classical Conditioning; Extinction; Motor Systems; Optogenetics; Purkinje Cell

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Reeves, A. R. (2016). A Mechanism for Extinction of Classically Conditioned Forelimb Movement in Mice. (Thesis). UCLA. Retrieved from http://www.escholarship.org/uc/item/7bc5m21n

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Reeves, Alexander Reeves. “A Mechanism for Extinction of Classically Conditioned Forelimb Movement in Mice.” 2016. Thesis, UCLA. Accessed April 16, 2021. http://www.escholarship.org/uc/item/7bc5m21n.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Reeves, Alexander Reeves. “A Mechanism for Extinction of Classically Conditioned Forelimb Movement in Mice.” 2016. Web. 16 Apr 2021.

Vancouver:

Reeves AR. A Mechanism for Extinction of Classically Conditioned Forelimb Movement in Mice. [Internet] [Thesis]. UCLA; 2016. [cited 2021 Apr 16]. Available from: http://www.escholarship.org/uc/item/7bc5m21n.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Reeves AR. A Mechanism for Extinction of Classically Conditioned Forelimb Movement in Mice. [Thesis]. UCLA; 2016. Available from: http://www.escholarship.org/uc/item/7bc5m21n

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

12. Singh, Maharaj. The role of extra unconditioned stimulus in classical conditioning;.

Degree: Psychology, 1983, Chaudhary Charan Singh University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/24489

Abstract Included newline

Bibliography p. 68-74

Advisors/Committee Members: Rai, S N.

Subjects/Keywords: Role; Unconditioned Stimulus; Classical Conditioning

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APA (6^th Edition):

Singh, M. (1983). The role of extra unconditioned stimulus in classical conditioning;. (Thesis). Chaudhary Charan Singh University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/24489

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Singh, Maharaj. “The role of extra unconditioned stimulus in classical conditioning;.” 1983. Thesis, Chaudhary Charan Singh University. Accessed April 16, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/24489.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Singh, Maharaj. “The role of extra unconditioned stimulus in classical conditioning;.” 1983. Web. 16 Apr 2021.

Vancouver:

Singh M. The role of extra unconditioned stimulus in classical conditioning;. [Internet] [Thesis]. Chaudhary Charan Singh University; 1983. [cited 2021 Apr 16]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/24489.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Singh M. The role of extra unconditioned stimulus in classical conditioning;. [Thesis]. Chaudhary Charan Singh University; 1983. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/24489

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Boston University

13. Yao, Zhaojie. Development of analysis approaches to calcium-imaging data of hippocampal neurons associated with classical conditioning in mice.

Degree: MS, Biomedical Engineering, 2016, Boston University

URL: http://hdl.handle.net/2144/19497

► Recent improvements in high performance fluorescent sensors and scientific CMOS cameras enable optical imaging of neural networks at a much larger scale. Our lab has demonstrated… (more)

▼ Recent improvements in high performance fluorescent sensors and scientific CMOS cameras enable optical imaging of neural networks at a much larger scale. Our lab has demonstrated the ability of wide-field calcium-imaging (using GCaMP6f) to capture the concurrent dynamic activity from hundreds to thousands of neurons over millimeters of brain tissue in behaving mice. The expansiveness of the neuronal network captured by the system requires innovation in data analysis methods. This thesis explores data analysis techniques to extract dynamics of hippocampal neural network containing a large number of individual neurons recorded using GCaMP6, while mice were learning a classical eye puff conditioning behavior. GCaMP6 fluorescence signals in each neuron is first considered one dimension, and each dataset thus contains hundreds to thousands dimensions. To understand the network structure, we first performed dimension reduction technique to examine the low-dimension evolution of the neural trajectory using Gaussian Process Factor Analysis, which smooths across dimensions, while extracting the low dimension representation. Because of the slow time course of GCaMP6 signals, the Factor Analysis was biased to the long lasting decay phase of the signal that does not represent neural activities. We found that it is critical to first estimate the spike train inference prior to application of dimension reduction, such as using the Fast Nonnegative Deconvolution method. While the low-dimension presentation described intriguing features in the neural trajectories that paralleled the learning behavior of the animal, to further quantify the network changes we directly examined the network in the high dimension space. We calculated the changes in the distance of the network trajectory over time in the high dimension space without any filtering, and compared across different phases of the behavioral states. We found that the speed of the trajectory in the high dimension space is significantly higher when animal learned the task, and the trajectory travelled much further away from baseline during the delay phase of the conditioning behavior. Together, these results demonstrate that dimension reduction analysis technique and the network trajectory within the non-reduced high dimension space can capture evolving features of neural networks recorded using calcium imaging. While this thesis concerns the hippocampal dynamics during learning, such data analysis techniques are expected to be broadly applicable to other behaviorally relevant networks.

Subjects/Keywords: Neurosciences; Calcium-imaging; Classical conditioning; Dimensionality reduction; Hippocampus

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APA (6^th Edition):

Yao, Z. (2016). Development of analysis approaches to calcium-imaging data of hippocampal neurons associated with classical conditioning in mice. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/19497

Chicago Manual of Style (16^th Edition):

Yao, Zhaojie. “Development of analysis approaches to calcium-imaging data of hippocampal neurons associated with classical conditioning in mice.” 2016. Masters Thesis, Boston University. Accessed April 16, 2021. http://hdl.handle.net/2144/19497.

MLA Handbook (7^th Edition):

Yao, Zhaojie. “Development of analysis approaches to calcium-imaging data of hippocampal neurons associated with classical conditioning in mice.” 2016. Web. 16 Apr 2021.

Vancouver:

Yao Z. Development of analysis approaches to calcium-imaging data of hippocampal neurons associated with classical conditioning in mice. [Internet] [Masters thesis]. Boston University; 2016. [cited 2021 Apr 16]. Available from: http://hdl.handle.net/2144/19497.

Council of Science Editors:

Yao Z. Development of analysis approaches to calcium-imaging data of hippocampal neurons associated with classical conditioning in mice. [Masters Thesis]. Boston University; 2016. Available from: http://hdl.handle.net/2144/19497

14. Soanes, Grant Paul. Visual and chemical learning in the pond snail, Lymnaea stagnalis.

Degree: PhD, 1999, University of Sussex

URL: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285369

Subjects/Keywords: 590; Mollusc; Classical conditioning

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APA (6^th Edition):

Soanes, G. P. (1999). Visual and chemical learning in the pond snail, Lymnaea stagnalis. (Doctoral Dissertation). University of Sussex. Retrieved from https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285369

Chicago Manual of Style (16^th Edition):

Soanes, Grant Paul. “Visual and chemical learning in the pond snail, Lymnaea stagnalis.” 1999. Doctoral Dissertation, University of Sussex. Accessed April 16, 2021. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285369.

MLA Handbook (7^th Edition):

Soanes, Grant Paul. “Visual and chemical learning in the pond snail, Lymnaea stagnalis.” 1999. Web. 16 Apr 2021.

Vancouver:

Soanes GP. Visual and chemical learning in the pond snail, Lymnaea stagnalis. [Internet] [Doctoral dissertation]. University of Sussex; 1999. [cited 2021 Apr 16]. Available from: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285369.

Council of Science Editors:

Soanes GP. Visual and chemical learning in the pond snail, Lymnaea stagnalis. [Doctoral Dissertation]. University of Sussex; 1999. Available from: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285369

University of Kansas

15. Savage, Kristyn Echterling. The Effects of a Multicomponent Intervention on Treatment Integrity of Counterconditioning for Aggression in Dogs.

Degree: PhD, Applied Behavioral Science, 2011, University of Kansas

URL: http://hdl.handle.net/1808/9765

► The purpose of this study was to examine the effects of consumer management procedures on dog owner treatment integrity. A within subjects comparison was made.… (more)

Subjects/Keywords: Behavioral sciences; Aggression; Classical conditioning; Dog; Generalization; Treatment integrity

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APA (6^th Edition):

Savage, K. E. (2011). The Effects of a Multicomponent Intervention on Treatment Integrity of Counterconditioning for Aggression in Dogs. (Doctoral Dissertation). University of Kansas. Retrieved from http://hdl.handle.net/1808/9765

Chicago Manual of Style (16^th Edition):

Savage, Kristyn Echterling. “The Effects of a Multicomponent Intervention on Treatment Integrity of Counterconditioning for Aggression in Dogs.” 2011. Doctoral Dissertation, University of Kansas. Accessed April 16, 2021. http://hdl.handle.net/1808/9765.

MLA Handbook (7^th Edition):

Savage, Kristyn Echterling. “The Effects of a Multicomponent Intervention on Treatment Integrity of Counterconditioning for Aggression in Dogs.” 2011. Web. 16 Apr 2021.

Vancouver:

Savage KE. The Effects of a Multicomponent Intervention on Treatment Integrity of Counterconditioning for Aggression in Dogs. [Internet] [Doctoral dissertation]. University of Kansas; 2011. [cited 2021 Apr 16]. Available from: http://hdl.handle.net/1808/9765.

Council of Science Editors:

Savage KE. The Effects of a Multicomponent Intervention on Treatment Integrity of Counterconditioning for Aggression in Dogs. [Doctoral Dissertation]. University of Kansas; 2011. Available from: http://hdl.handle.net/1808/9765

Texas Christian University

16. Dudley, R. Thomas. Pavlovian performance following unexpected reward omissions / by R. Thomas Dudley.

Degree: 1994, Texas Christian University

URL: https://repository.tcu.edu/handle/116099117/34814

Subjects/Keywords: Frustration; Classical conditioning; Control (Psychology)

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APA (6^th Edition):

Dudley, R. T. (1994). Pavlovian performance following unexpected reward omissions / by R. Thomas Dudley. (Thesis). Texas Christian University. Retrieved from https://repository.tcu.edu/handle/116099117/34814

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Dudley, R Thomas. “Pavlovian performance following unexpected reward omissions / by R. Thomas Dudley.” 1994. Thesis, Texas Christian University. Accessed April 16, 2021. https://repository.tcu.edu/handle/116099117/34814.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Dudley, R Thomas. “Pavlovian performance following unexpected reward omissions / by R. Thomas Dudley.” 1994. Web. 16 Apr 2021.

Vancouver:

Dudley RT. Pavlovian performance following unexpected reward omissions / by R. Thomas Dudley. [Internet] [Thesis]. Texas Christian University; 1994. [cited 2021 Apr 16]. Available from: https://repository.tcu.edu/handle/116099117/34814.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Dudley RT. Pavlovian performance following unexpected reward omissions / by R. Thomas Dudley. [Thesis]. Texas Christian University; 1994. Available from: https://repository.tcu.edu/handle/116099117/34814

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

McGill University

17. Pasquali, Paula E. Contiguity and informational variables in classical conditioning.

Degree: PhD, Department of Psychology, 1979, McGill University

URL: https://escholarship.mcgill.ca/downloads/td96k505r.pdf ; https://escholarship.mcgill.ca/concern/theses/d791sj77v

►

This thesis investigates the role of the animal's uncertainty about the time of presentation of unconditioned stimuli (UCS) in the development and maintenance of the… (more)

▼

This thesis investigates the role of the animal's uncertainty about the time of presentation of unconditioned stimuli (UCS) in the development and maintenance of the responding established with classical conditioning procedures. This question was examined through an analysis of anticipatory conditioned licking when the thirsty rat is, or is not, given information about the exact time of water deliveries. Less conditioned licking and longer response latencies to a temporally prior conditioned stimulus (CS) were observed when a second, brief (0.5 sec) marker stimulus coincided with the onset of water presentation during conditioning trials. It was shown that the presentation of the marker stimulus at unpredictable times during conditioning trials did not result in any general disruption of or interference with conditioning to the CS. Moreover, no evidence was found that the attenuation of conditioned licking was attributable to the development of inhibition to the CS. [...]

Le but de cette thèse est d'investiguer le rôle de l'incertitude de l'animal en ce qui concerne le temps de présentation de stimuli inconditionnels (UCS) dans le développement et le maintien de réponses établies par des procédures de conditionnement classique. Cette question fut examinée par une analyse de lappement conditionnel d'anticipation lorsqu'un rat assoiffe est, ou n'est pas, informe du temps exact des présentations d'eau. Moins de lappement conditionnel et de plus grandes latences de réponse à un stimulus conditionnel antérieur furent observes lorsqu'un second stimulus de courte durée (0.5 sec) coïncidait avec le début de la présentation d'eau, durant les essais de conditionnement. Il fut démontré que la présentation du stimulus marqueur a des moments imprédictibles durant les essais de conditionnement ne produit pas de dérèglement ou d'interférence avec le conditionnement au CS. De plus, qu'une diminution du lappement conditionnel soit attribuable au développement d'une inhibition au CS ne fut pas démontré. […]

Advisors/Committee Members: Dr. Dalbir Bindra.

Subjects/Keywords: Rats – Behavior.; Classical conditioning.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pasquali, P. E. (1979). Contiguity and informational variables in classical conditioning. (Doctoral Dissertation). McGill University. Retrieved from https://escholarship.mcgill.ca/downloads/td96k505r.pdf ; https://escholarship.mcgill.ca/concern/theses/d791sj77v

Chicago Manual of Style (16^th Edition):

Pasquali, Paula E. “Contiguity and informational variables in classical conditioning.” 1979. Doctoral Dissertation, McGill University. Accessed April 16, 2021. https://escholarship.mcgill.ca/downloads/td96k505r.pdf ; https://escholarship.mcgill.ca/concern/theses/d791sj77v.

MLA Handbook (7^th Edition):

Pasquali, Paula E. “Contiguity and informational variables in classical conditioning.” 1979. Web. 16 Apr 2021.

Vancouver:

Pasquali PE. Contiguity and informational variables in classical conditioning. [Internet] [Doctoral dissertation]. McGill University; 1979. [cited 2021 Apr 16]. Available from: https://escholarship.mcgill.ca/downloads/td96k505r.pdf ; https://escholarship.mcgill.ca/concern/theses/d791sj77v.

Council of Science Editors:

Pasquali PE. Contiguity and informational variables in classical conditioning. [Doctoral Dissertation]. McGill University; 1979. Available from: https://escholarship.mcgill.ca/downloads/td96k505r.pdf ; https://escholarship.mcgill.ca/concern/theses/d791sj77v

Montana State University

18. Johnson, Amy Sue. Associative morphine tolerance in the rat : a meta-analytic review.

Degree: MS, College of Letters & Science, 2002, Montana State University

URL: https://scholarworks.montana.edu/xmlui/handle/1/8265

Subjects/Keywords: Drug tolerance; Classical conditioning

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Johnson, A. S. (2002). Associative morphine tolerance in the rat : a meta-analytic review. (Masters Thesis). Montana State University. Retrieved from https://scholarworks.montana.edu/xmlui/handle/1/8265

Chicago Manual of Style (16^th Edition):

Johnson, Amy Sue. “Associative morphine tolerance in the rat : a meta-analytic review.” 2002. Masters Thesis, Montana State University. Accessed April 16, 2021. https://scholarworks.montana.edu/xmlui/handle/1/8265.

MLA Handbook (7^th Edition):

Johnson, Amy Sue. “Associative morphine tolerance in the rat : a meta-analytic review.” 2002. Web. 16 Apr 2021.

Vancouver:

Johnson AS. Associative morphine tolerance in the rat : a meta-analytic review. [Internet] [Masters thesis]. Montana State University; 2002. [cited 2021 Apr 16]. Available from: https://scholarworks.montana.edu/xmlui/handle/1/8265.

Council of Science Editors:

Johnson AS. Associative morphine tolerance in the rat : a meta-analytic review. [Masters Thesis]. Montana State University; 2002. Available from: https://scholarworks.montana.edu/xmlui/handle/1/8265

McGill University

19. Holahan, Matthew R. Amygdala involvement in aversive conditioning.

Degree: PhD, Department of Psychology, 2003, McGill University

URL: https://escholarship.mcgill.ca/downloads/3t945t070.pdf ; https://escholarship.mcgill.ca/concern/theses/9306t137b

► Research over the past several decades has revealed that the amygdala is involved in aversive, or fear, conditioning. However, the precise nature of this involvement… (more)

▼ Research over the past several decades has revealed that the amygdala is involved in aversive, or fear, conditioning. However, the precise nature of this involvement remains a matter of debate. One hypothesis suggests that disrupting amygdala function eliminates the storage of memories formed during aversive conditioning, eliminating the production of internal responses that alter the expression of observable behaviors. Alternatively, lesions or inactivation of the amygdala may impair the modulation of memories in other brain regions and disrupt the ability to perform certain observable behaviors. The experiments reported in the present thesis examined these arguments by making multiple behavioral measures during exposure to unconditioned (US) or conditioned (CS) aversive cues. Amygdala activity was inferred from changes in c-Fos protein expression or activity was temporarily suppressed with muscimol injections. The relationship between the behavioral measures and the role of the amygdala in producing them was examined. Amygdala neurons expressing the c-Fos protein tracked exposure to the US and CS but did not coincide with expression of freezing. Temporary inactivation of the amygdala with muscimol injections before presentation of the US or exposure to the CS attenuated the expression of freezing and active place avoidance; two incompatible behaviors. Finally, temporary inactivation of amygdala activity blocked freezing, place avoidance, and memory modulation produced by the same posttraining exposure to an aversive CS. Since amygdala activation alone was not sufficient to produce freezing and inactivation of the amygdala eliminated freezing, place avoidance, and memory modulation, the results cannot be interpreted as reflecting a direct role for the amygdala in production of observable behaviors. The results also preclude the idea that memory modulation is the only function of the amygdala. Rather, the results of all three studies suggest that the amygdala stores an aversive representation of the US which promotes the expression of various behaviors, possibly through the production of internal responses reflecting an aversive affective state.

Subjects/Keywords: Amygdaloid body.; Fear.; Classical conditioning.

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APA (6^th Edition):

Holahan, M. R. (2003). Amygdala involvement in aversive conditioning. (Doctoral Dissertation). McGill University. Retrieved from https://escholarship.mcgill.ca/downloads/3t945t070.pdf ; https://escholarship.mcgill.ca/concern/theses/9306t137b

Chicago Manual of Style (16^th Edition):

Holahan, Matthew R. “Amygdala involvement in aversive conditioning.” 2003. Doctoral Dissertation, McGill University. Accessed April 16, 2021. https://escholarship.mcgill.ca/downloads/3t945t070.pdf ; https://escholarship.mcgill.ca/concern/theses/9306t137b.

MLA Handbook (7^th Edition):

Holahan, Matthew R. “Amygdala involvement in aversive conditioning.” 2003. Web. 16 Apr 2021.

Vancouver:

Holahan MR. Amygdala involvement in aversive conditioning. [Internet] [Doctoral dissertation]. McGill University; 2003. [cited 2021 Apr 16]. Available from: https://escholarship.mcgill.ca/downloads/3t945t070.pdf ; https://escholarship.mcgill.ca/concern/theses/9306t137b.

Council of Science Editors:

Holahan MR. Amygdala involvement in aversive conditioning. [Doctoral Dissertation]. McGill University; 2003. Available from: https://escholarship.mcgill.ca/downloads/3t945t070.pdf ; https://escholarship.mcgill.ca/concern/theses/9306t137b

20. NC DOCKS at The University of North Carolina at Greensboro; Russell, Franklin Eugene. Pavlovian occasion-setting, attention and observing.

Degree: 1992, NC Docks

URL: http://libres.uncg.edu/ir/uncg/f/Russell_uncg_9302646.PDF

► Six pigeons were exposed to a procedure in which they could peck a white key to "observe" a 6-s keylight (CS) that was immediately followed… (more)

Subjects/Keywords: Classical conditioning; Attention; Observation (Psychology)

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APA (6^th Edition):

NC DOCKS at The University of North Carolina at Greensboro; Russell, F. E. (1992). Pavlovian occasion-setting, attention and observing. (Thesis). NC Docks. Retrieved from http://libres.uncg.edu/ir/uncg/f/Russell_uncg_9302646.PDF

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

NC DOCKS at The University of North Carolina at Greensboro; Russell, Franklin Eugene. “Pavlovian occasion-setting, attention and observing.” 1992. Thesis, NC Docks. Accessed April 16, 2021. http://libres.uncg.edu/ir/uncg/f/Russell_uncg_9302646.PDF.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

NC DOCKS at The University of North Carolina at Greensboro; Russell, Franklin Eugene. “Pavlovian occasion-setting, attention and observing.” 1992. Web. 16 Apr 2021.

Vancouver:

NC DOCKS at The University of North Carolina at Greensboro; Russell FE. Pavlovian occasion-setting, attention and observing. [Internet] [Thesis]. NC Docks; 1992. [cited 2021 Apr 16]. Available from: http://libres.uncg.edu/ir/uncg/f/Russell_uncg_9302646.PDF.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

NC DOCKS at The University of North Carolina at Greensboro; Russell FE. Pavlovian occasion-setting, attention and observing. [Thesis]. NC Docks; 1992. Available from: http://libres.uncg.edu/ir/uncg/f/Russell_uncg_9302646.PDF

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Lund

21. Rasmussen, Anders. Feedback control of cerebellar learning.

Degree: 2014, University of Lund

URL: https://lup.lub.lu.se/record/4437425 ; https://portal.research.lu.se/ws/files/3204185/4437426.pdf

► The ability to anticipate future events and to modify erroneous anticipatory actions is crucial for the survival of any organism. Both theoretical and empirical lines… (more)

▼ The ability to anticipate future events and to modify erroneous anticipatory actions is crucial for the survival of any organism. Both theoretical and empirical lines of evidence implicate the cerebellum in this ability. It is often suggested that the cerebellum acquires “expectations” or “internal models”. However, except in a metaphorical sense, the cerebellum, which consists of a set of interconnected nerve cells, cannot contain “internal models” or “have expectations”. The aim of this thesis is to untangle these metaphors by translating them back into neurophysiological cause and effect relationships. This task is approached from within the paradigm of classical conditioning, in which a subject, through repeated presentations of a conditional stimulus, followed by an unconditional stimulus, acquires a conditioned response. Importantly, the conditioned response is timed so that it anticipates the unconditioned response. Available neurophysiological evidence suggests that Purkinje cells, in the cerebellar cortex, generate the conditioned response. In addition, Purkinje cells provide negative feedback to the IO, which is a relay for the unconditional stimulus, via the nucleo-olivary pathway. Purkinje cells can therefore regulate the intensity of the signal derived from the unconditional stimulus, which, in turn, decides subsequent plasticity. Hence, as learning progresses, the IO signal will become weaker and weaker due to increasing negative feedback from Purkinje cells. Thus, in an important sense, learning induced changes in Purkinje cell activity constitute an “expectation” or “anticipation” of a future event (the unconditional stimulus), and, consistent with theoretical models, future learning depends on the accuracy of this expectation. Paper 1 in this thesis show that learned changes in Purkinje cells influences subsequent IO activity. The second paper show that, depending on the number of pulses it contains, the signal from the IO to the Purkinje cells can either cause acquisition or extinction. In the third paper we present evidence that can potentially help explain overexpectation, a behavioral phenomenon, which have for long been elusive. Collectively these papers advance our understanding of the feedback mechanisms that govern cerebellar learning and it proposes a potential solution to some long standing behavioral conundrums.

Subjects/Keywords: Neurosciences; Motor learning; Rescorla-Wagner; Anticipation; In vivo Electrophysiology; Purkinje cells; Nucleo-Olivary inhibition; Inferior Olive; Classical Conditioning; Eyeblink Conditioning; Feedback

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APA (6^th Edition):

Rasmussen, A. (2014). Feedback control of cerebellar learning. (Doctoral Dissertation). University of Lund. Retrieved from https://lup.lub.lu.se/record/4437425 ; https://portal.research.lu.se/ws/files/3204185/4437426.pdf

Chicago Manual of Style (16^th Edition):

Rasmussen, Anders. “Feedback control of cerebellar learning.” 2014. Doctoral Dissertation, University of Lund. Accessed April 16, 2021. https://lup.lub.lu.se/record/4437425 ; https://portal.research.lu.se/ws/files/3204185/4437426.pdf.

MLA Handbook (7^th Edition):

Rasmussen, Anders. “Feedback control of cerebellar learning.” 2014. Web. 16 Apr 2021.

Vancouver:

Rasmussen A. Feedback control of cerebellar learning. [Internet] [Doctoral dissertation]. University of Lund; 2014. [cited 2021 Apr 16]. Available from: https://lup.lub.lu.se/record/4437425 ; https://portal.research.lu.se/ws/files/3204185/4437426.pdf.

Council of Science Editors:

Rasmussen A. Feedback control of cerebellar learning. [Doctoral Dissertation]. University of Lund; 2014. Available from: https://lup.lub.lu.se/record/4437425 ; https://portal.research.lu.se/ws/files/3204185/4437426.pdf

22. Silva, Douglas Marques da. Condicionamento ao local induzido por etanol em ratos : revisão metodológica e estudo experimental.

Degree: 2017, Brazil

URL: http://hdl.handle.net/10183/201581

►

Desde a década de 1950, o modelo de condicionamento ao local (MCL) tem sido usado no estudo dos efeitos motivacionais de farmacos em ratos. Apesar… (more)

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Desde a década de 1950, o modelo de condicionamento ao local (MCL) tem sido usado no estudo dos efeitos motivacionais de farmacos em ratos. Apesar do uso frequente do MCL no estudo de variáveis farmacológicas, ambientais, genéticas e neurofisiológicas envolvidas no controle do comportamento de busca por etanol, as condições sob as quais o etanol induz condicionamento ao local em ratos continuam pouco esclarecidas. Neste trabalho, foi realizada revisão metodológica de 262 experimentos reportados em 62 artigos de pesquisa em MCL com etanol em ratos. A revisão mostra que a produção de preferência condicionada ao local (PCL), aversão condicionada ao local (ACL) e de falha de condicionamento (NS) aparenta ser majoritariamente decorrente de interações de cinco fatores: (a) o sistema de armazenamento nas gaiolas-viveiro; (b) o aparato de MCL utilizado; (c) a dose de etanol administrada; (d) o número de sessões de habituação e (e) o número de sessões de condicionamento (protocolo curto de condicionamento = 10 ou menos sessões de condicionamento; protocolo longo de condicionamento = 12 ou mais sessões de condicionamento). Desses fatores, o aparato aparenta ser o mais preponderante à produção de PCL, ACL e NS: (1) aparatos com comprimento ≤ 75 cm e largura > 20 cm têm maior probabilidade de produzirem PCL em protocolo curtos de condicionamento quando a dose de etanol é baixa (0,5 a 1,0 g/kg, ip; 1,0 a 1,5 g/kg, ig); (2) aparatos com comprimento > 75 cm e largura ≥ 20 cm tendem a produzir NS e ACL em protocolos curtos de condicionamento de forma dependente da dose de etanol administrada, sendo que quanto maior a dose, maior a probabilidade de ACL; (3) aparatos com comprimento > 75 cm e largura ≥ 20 cm tendem a produzir PCL somente quando protocolos longos de condicionamento são implementados; (4) aparatos com largura < 20 cm só produzem NS e ACL, independentemente dos protocolos de condicionamento implementados e das doses de etanol administradas. No trabalho experimental decorrente foram estudadas interações de variáveis que a revisão não pôde alcançar. Os resultados demonstram que interações entre (a) horário de condicionamento, (b) presença/ausência de fase de habituação no protocolo e (c) intervalo interfásico também ocorrem na produção de NS ou de PCL. De acordo com o horário, o mesmo protocolo de condicionamento sem fase habituação produz NS ou PCL (horários de 07:50-09:50 e 10:30-12:30, respectivamente), (2) a inserção de fase de habituação no horário de 10:30-12:30 produz NS e (3), mantendo a fase de habituação no mesmo horário, o aumento do intervalo interfásico de 24 para 48 horas reestabelece PCL. Conclui-se que o etanol não é menos reforçador que outras drogas de abuso no MCL, mas é mais sensível a outras variáveis.

Since the 1950s, the Place Conditioning Paradigm (PCP) has been used in the study of the motivational effects of drugs in rats. Despite the frequent use of PCP in the study of pharmacological, environmental, genetic e neurophysiological variables involved in the control of ethanol search behavior, the…

Advisors/Committee Members: Leal, Mirna Bainy, Carvalho, José Inácio Lemos Monteiro.

Subjects/Keywords: Modelos animais; Condicionamento clássico; Etanol; Comportamento animal; Sistema nervoso central; Methodological review; Classical conditioning; Place conditioning

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APA (6^th Edition):

Silva, D. M. d. (2017). Condicionamento ao local induzido por etanol em ratos : revisão metodológica e estudo experimental. (Masters Thesis). Brazil. Retrieved from http://hdl.handle.net/10183/201581

Chicago Manual of Style (16^th Edition):

Silva, Douglas Marques da. “Condicionamento ao local induzido por etanol em ratos : revisão metodológica e estudo experimental.” 2017. Masters Thesis, Brazil. Accessed April 16, 2021. http://hdl.handle.net/10183/201581.

MLA Handbook (7^th Edition):

Silva, Douglas Marques da. “Condicionamento ao local induzido por etanol em ratos : revisão metodológica e estudo experimental.” 2017. Web. 16 Apr 2021.

Vancouver:

Silva DMd. Condicionamento ao local induzido por etanol em ratos : revisão metodológica e estudo experimental. [Internet] [Masters thesis]. Brazil; 2017. [cited 2021 Apr 16]. Available from: http://hdl.handle.net/10183/201581.

Council of Science Editors:

Silva DMd. Condicionamento ao local induzido por etanol em ratos : revisão metodológica e estudo experimental. [Masters Thesis]. Brazil; 2017. Available from: http://hdl.handle.net/10183/201581

23. Quinn, Barbara Hunter. The Effects of amygdalar lesions on heart rate responses in rats.

Degree: MS, 1981, Oregon Health Sciences University

URL: doi:10.6083/M4KH0KH1 ; http://digitalcommons.ohsu.edu/etd/2240

Subjects/Keywords: Heart Rate; Rats; Amygdala; Conditioning, Classical

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APA (6^th Edition):

Quinn, B. H. (1981). The Effects of amygdalar lesions on heart rate responses in rats. (Thesis). Oregon Health Sciences University. Retrieved from doi:10.6083/M4KH0KH1 ; http://digitalcommons.ohsu.edu/etd/2240

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Quinn, Barbara Hunter. “The Effects of amygdalar lesions on heart rate responses in rats.” 1981. Thesis, Oregon Health Sciences University. Accessed April 16, 2021. doi:10.6083/M4KH0KH1 ; http://digitalcommons.ohsu.edu/etd/2240.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Quinn, Barbara Hunter. “The Effects of amygdalar lesions on heart rate responses in rats.” 1981. Web. 16 Apr 2021.

Vancouver:

Quinn BH. The Effects of amygdalar lesions on heart rate responses in rats. [Internet] [Thesis]. Oregon Health Sciences University; 1981. [cited 2021 Apr 16]. Available from: doi:10.6083/M4KH0KH1 ; http://digitalcommons.ohsu.edu/etd/2240.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Quinn BH. The Effects of amygdalar lesions on heart rate responses in rats. [Thesis]. Oregon Health Sciences University; 1981. Available from: doi:10.6083/M4KH0KH1 ; http://digitalcommons.ohsu.edu/etd/2240

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

24. Ostroff, Robert L. The Role of thermoregulatory development in performance of heat-reinforced authoshaping in chicks.

Degree: MS, 1984, Oregon Health Sciences University

URL: doi:10.6083/M4M61HDF ; http://digitalcommons.ohsu.edu/etd/2085

Subjects/Keywords: Chickens; Body Temperature Regulation; Conditioning, Classical

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APA (6^th Edition):

Ostroff, R. L. (1984). The Role of thermoregulatory development in performance of heat-reinforced authoshaping in chicks. (Thesis). Oregon Health Sciences University. Retrieved from doi:10.6083/M4M61HDF ; http://digitalcommons.ohsu.edu/etd/2085

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ostroff, Robert L. “The Role of thermoregulatory development in performance of heat-reinforced authoshaping in chicks.” 1984. Thesis, Oregon Health Sciences University. Accessed April 16, 2021. doi:10.6083/M4M61HDF ; http://digitalcommons.ohsu.edu/etd/2085.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ostroff, Robert L. “The Role of thermoregulatory development in performance of heat-reinforced authoshaping in chicks.” 1984. Web. 16 Apr 2021.

Vancouver:

Ostroff RL. The Role of thermoregulatory development in performance of heat-reinforced authoshaping in chicks. [Internet] [Thesis]. Oregon Health Sciences University; 1984. [cited 2021 Apr 16]. Available from: doi:10.6083/M4M61HDF ; http://digitalcommons.ohsu.edu/etd/2085.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ostroff RL. The Role of thermoregulatory development in performance of heat-reinforced authoshaping in chicks. [Thesis]. Oregon Health Sciences University; 1984. Available from: doi:10.6083/M4M61HDF ; http://digitalcommons.ohsu.edu/etd/2085

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

25. Mansfield, James Guy. Behavioral influences on tolerance to ethanol.

Degree: PhD, 1979, Oregon Health Sciences University

URL: doi:10.6083/M46T0JTB ; http://digitalcommons.ohsu.edu/etd/2328

Subjects/Keywords: Ethanol; Ethanol – pharmacology; Conditioning, Classical; Rats

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mansfield, J. G. (1979). Behavioral influences on tolerance to ethanol. (Doctoral Dissertation). Oregon Health Sciences University. Retrieved from doi:10.6083/M46T0JTB ; http://digitalcommons.ohsu.edu/etd/2328

Chicago Manual of Style (16^th Edition):

Mansfield, James Guy. “Behavioral influences on tolerance to ethanol.” 1979. Doctoral Dissertation, Oregon Health Sciences University. Accessed April 16, 2021. doi:10.6083/M46T0JTB ; http://digitalcommons.ohsu.edu/etd/2328.

MLA Handbook (7^th Edition):

Mansfield, James Guy. “Behavioral influences on tolerance to ethanol.” 1979. Web. 16 Apr 2021.

Vancouver:

Mansfield JG. Behavioral influences on tolerance to ethanol. [Internet] [Doctoral dissertation]. Oregon Health Sciences University; 1979. [cited 2021 Apr 16]. Available from: doi:10.6083/M46T0JTB ; http://digitalcommons.ohsu.edu/etd/2328.

Council of Science Editors:

Mansfield JG. Behavioral influences on tolerance to ethanol. [Doctoral Dissertation]. Oregon Health Sciences University; 1979. Available from: doi:10.6083/M46T0JTB ; http://digitalcommons.ohsu.edu/etd/2328

Texas A&M University

26. Sheehan, Kathleen Sue. Classical conditioning and the treatment of insomnia.

Degree: MS, psychology, 2012, Texas A&M University

URL: http://hdl.handle.net/1969.1/ETD-TAMU-1976-THESIS-S541

Subjects/Keywords: psychology.; Major psychology.; Insomnia.; Classical conditioning.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sheehan, K. S. (2012). Classical conditioning and the treatment of insomnia. (Masters Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/ETD-TAMU-1976-THESIS-S541

Chicago Manual of Style (16^th Edition):

Sheehan, Kathleen Sue. “Classical conditioning and the treatment of insomnia.” 2012. Masters Thesis, Texas A&M University. Accessed April 16, 2021. http://hdl.handle.net/1969.1/ETD-TAMU-1976-THESIS-S541.

MLA Handbook (7^th Edition):

Sheehan, Kathleen Sue. “Classical conditioning and the treatment of insomnia.” 2012. Web. 16 Apr 2021.

Vancouver:

Sheehan KS. Classical conditioning and the treatment of insomnia. [Internet] [Masters thesis]. Texas A&M University; 2012. [cited 2021 Apr 16]. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-1976-THESIS-S541.

Council of Science Editors:

Sheehan KS. Classical conditioning and the treatment of insomnia. [Masters Thesis]. Texas A&M University; 2012. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-1976-THESIS-S541

University of Alabama

27. Powell, Patrick Snow. Impaired classical conditioning in persons with autism spectrum disorders.

Degree: 2011, University of Alabama

URL: http://purl.lib.ua.edu/77707

► Previous research has indicated that individuals with autism spectrum disorder (ASD) have difficulty with implicit learning; learning that occurs unconsciously and without intention. The present… (more)

Subjects/Keywords: Electronic Thesis or Dissertation; – thesis; Psychology; Physiological psychology; autism; classical conditioning; implicit learning

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APA (6^th Edition):

Powell, P. S. (2011). Impaired classical conditioning in persons with autism spectrum disorders. (Thesis). University of Alabama. Retrieved from http://purl.lib.ua.edu/77707

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Powell, Patrick Snow. “Impaired classical conditioning in persons with autism spectrum disorders.” 2011. Thesis, University of Alabama. Accessed April 16, 2021. http://purl.lib.ua.edu/77707.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Powell, Patrick Snow. “Impaired classical conditioning in persons with autism spectrum disorders.” 2011. Web. 16 Apr 2021.

Vancouver:

Powell PS. Impaired classical conditioning in persons with autism spectrum disorders. [Internet] [Thesis]. University of Alabama; 2011. [cited 2021 Apr 16]. Available from: http://purl.lib.ua.edu/77707.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Powell PS. Impaired classical conditioning in persons with autism spectrum disorders. [Thesis]. University of Alabama; 2011. Available from: http://purl.lib.ua.edu/77707

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Georgia

28. Gabriel, Janice K. Double standards.

Degree: 2014, University of Georgia

URL: http://hdl.handle.net/10724/22650

► The purpose of this study was to perform a content analysis of present day advertising’s use of emotional and rational appeals in magazines. It investigated… (more)

Subjects/Keywords: Advertising Appeals; Rational Appeals; Emotional Appeals, FCB Grid; Magazine Advertising; Gender Advertising; Classical Conditioning

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APA (6^th Edition):

Gabriel, J. K. (2014). Double standards. (Thesis). University of Georgia. Retrieved from http://hdl.handle.net/10724/22650

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gabriel, Janice K. “Double standards.” 2014. Thesis, University of Georgia. Accessed April 16, 2021. http://hdl.handle.net/10724/22650.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gabriel, Janice K. “Double standards.” 2014. Web. 16 Apr 2021.

Vancouver:

Gabriel JK. Double standards. [Internet] [Thesis]. University of Georgia; 2014. [cited 2021 Apr 16]. Available from: http://hdl.handle.net/10724/22650.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gabriel JK. Double standards. [Thesis]. University of Georgia; 2014. Available from: http://hdl.handle.net/10724/22650

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

29. Adriane M dela Cruz. Learning to be a cocaine addict: behavioral, pharmacological, and molecular characterization of individual differences in initial learning of cocaine-environment associations.

Degree: PhD, Neuroscience, 2009, The University of Texas Medical Branch

URL: http://hdl.handle.net/2152.3/233

► Cocaine addiction is a chronic, relapsing disease affecting millions of Americans, and differences between individuals modulate the progression from cocaine use to addiction. Learned associations… (more)

▼ Cocaine addiction is a chronic, relapsing disease affecting millions of Americans, and differences between individuals modulate the progression from cocaine use to addiction. Learned associations between cocaine and environmental stimuli develop in the subset of patients who become addicted, and exposure to these stimuli facilitates relapse to cocaine-taking. Classical conditioning underlies the development and expression of these learned associations, and several systems implicated in both the behavioral response to cocaine and in learning and memory—e.g., serotonin2 receptors (5-HT2R), ionotropic α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) glutamate receptor subunit 1 (GluR1), and a signaling system associated with these receptors (i.e., the mitogen-activated protein kinase extracellular-signal regulated kinase; ERK) in the cortical-limbic regions – may modulate the acquisition and expression of cocaine-environment associations. Individual differences play a major role in the development of addiction, and behavioral models are needed study these implications in the learning of cocaine-environment associations. We utilized the conditioned place preference (CPP) paradigm in laboratory rats to model cocaine-environment associations and developed a new method for the analysis of CPP data that allows for identification of factors that modulate individual sensitivity to the development of cocaine-environment associations, pharmacological treatments that are effective only in subpopulations of subjects, and molecular neuroadaptations that differ among subjects susceptible to the development of cocaine-environment associations and non-susceptible individuals. We uncovered roles for 5-HT2R in the acquisition and expression of cocaine-environment associations formed after a single pairing of cocaine and environment, suggesting a role for these receptors in modulating the development and retrieval of initial cocaine-environment associations. We observed an increase in the phosphorylation of GluR1 and enhanced expression of total ERK protein in the prefrontal cortex upon retrieval of cocaine-environment associations. These studies suggest that the ability to learn strong cocaine-environment associations is associated with a unique set of neuroadaptations and is a predictor of those who will initiate development of a cocaine addiction. Advisors/Committee Members: Kathryn A. Cunningham (advisor), Xiaodong Cheng (committee member), Mary Jeanne Kreek (committee member), Kenneth Johnson (committee member), Joel Gallagher (committee member).

Subjects/Keywords: conditioned place preference; cocaine; classical conditioning

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APA (6^th Edition):

Cruz, A. M. d. (2009). Learning to be a cocaine addict: behavioral, pharmacological, and molecular characterization of individual differences in initial learning of cocaine-environment associations. (Doctoral Dissertation). The University of Texas Medical Branch. Retrieved from http://hdl.handle.net/2152.3/233

Chicago Manual of Style (16^th Edition):

Cruz, Adriane M dela. “Learning to be a cocaine addict: behavioral, pharmacological, and molecular characterization of individual differences in initial learning of cocaine-environment associations.” 2009. Doctoral Dissertation, The University of Texas Medical Branch. Accessed April 16, 2021. http://hdl.handle.net/2152.3/233.

MLA Handbook (7^th Edition):

Cruz, Adriane M dela. “Learning to be a cocaine addict: behavioral, pharmacological, and molecular characterization of individual differences in initial learning of cocaine-environment associations.” 2009. Web. 16 Apr 2021.

Vancouver:

Cruz AMd. Learning to be a cocaine addict: behavioral, pharmacological, and molecular characterization of individual differences in initial learning of cocaine-environment associations. [Internet] [Doctoral dissertation]. The University of Texas Medical Branch; 2009. [cited 2021 Apr 16]. Available from: http://hdl.handle.net/2152.3/233.

Council of Science Editors:

Cruz AMd. Learning to be a cocaine addict: behavioral, pharmacological, and molecular characterization of individual differences in initial learning of cocaine-environment associations. [Doctoral Dissertation]. The University of Texas Medical Branch; 2009. Available from: http://hdl.handle.net/2152.3/233

University of Southern California

30. Lee, Ka Hung. Eyeblink conditioning in mutant mice.

Degree: PhD, Neuroscience, 2007, University of Southern California

URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/329731/rec/2697

► Eyeblink conditioning has been used extensively in rabbits to study the role of the cerebellum in motor learning and memory for many years. The well-organized… (more)

▼ Eyeblink conditioning has been used extensively in rabbits to study the role of the cerebellum in motor learning and memory for many years. The well-organized anatomy of the cerebellum allows a mapping of the circuitry essential for eyeblink conditioning. The convergent inputs of parallel and climbing fibers at the Purkinje cells and mossy and climbing fiber collaterals at the interpositus nuclei provide 2 simultaneous coincidence detection pathways for conditioned stimuli (CS) and unconditioned stimuli (US). Different synaptic plasticities are found in these 2 pathways in the cerebellar cortex and deep cerebellum, establishing the cerebellum as a motor learning machine. Before diving into the fascinating world of mutant/transgenic mice, one has to make sure that the mice and rabbits share similar eyeblink circuitry in the cerebellum. It has been repeatedly shown in rabbits that lesioning of the interpositus nuclei abolishes previously acquired conditioned eyeblink responses (CRs). Similarly, bilateral lesioning of the interpositus nuclei after acquiring eyeblink conditioning also abolishes CRs in C57BL/6 mice. The results suggest that the motor memory trace is mediated at the interpositus nuclei in the deep cerebellum.; The advent of genetically engineered mice makes it possible to study the functions of different genes involving cerebellar-dependent motor learning and memory. Tissue- or cell type-specific mutants/transgenics, such as mice with pcp/L7 promoters, prove that the cerebellum is necessary for motor learning and memory. The use of CaMKIV KO and CRD-NRG-1 heterozygous mutant mice in eyeblink conditioning sheds light on how the interpositus nuclei mediates motor memory; moreover, the use of HCN1 KO, CaMKIV KO, PMCA2 KO, and CRD-NRG-1 heterozygous mutant mice provides insight into how the cerebellar cortex modulates motor learning, such as the temporal properties of CRs. Finally, the offspring from PolyI:C-injected pregnant mice offer a putative model for studying autism. Advisors/Committee Members: Thompson, Richard F. (Committee Chair), Baudry, Michel (Committee Member), Lavond, David G. (Committee Member), Swanson, Larry W. (Committee Member), Walsh, David A. (Committee Member).

Subjects/Keywords: LTD; LTP; engram; classical conditioning; Pavlov

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APA (6^th Edition):

Lee, K. H. (2007). Eyeblink conditioning in mutant mice. (Doctoral Dissertation). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/329731/rec/2697

Chicago Manual of Style (16^th Edition):

Lee, Ka Hung. “Eyeblink conditioning in mutant mice.” 2007. Doctoral Dissertation, University of Southern California. Accessed April 16, 2021. http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/329731/rec/2697.

MLA Handbook (7^th Edition):

Lee, Ka Hung. “Eyeblink conditioning in mutant mice.” 2007. Web. 16 Apr 2021.

Vancouver:

Lee KH. Eyeblink conditioning in mutant mice. [Internet] [Doctoral dissertation]. University of Southern California; 2007. [cited 2021 Apr 16]. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/329731/rec/2697.

Council of Science Editors:

Lee KH. Eyeblink conditioning in mutant mice. [Doctoral Dissertation]. University of Southern California; 2007. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/329731/rec/2697

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Open Access Theses and Dissertations