You searched for subject:(chronic disease).
Showing records 1 – 30 of
1777 total matches.
◁ [1] [2] [3] [4] [5] … [60] ▶
University of Hawaii – Manoa
1.
Beckford, Fanchon Z.
Are world cancer research fund and american institute for cancer research recommendations for cancer prevention associated with known chronic disease biomarkers in healthy women?.
Degree: 2015, University of Hawaii – Manoa
URL: http://hdl.handle.net/10125/100293 
► M.S. University of Hawaii at Manoa 2014.
Chronic disease is a leading cause of mortality and morbidity in the United States. Nutritional, lifestyle, hormonal, and…
(more)
▼ M.S. University of Hawaii at Manoa 2014.
Chronic disease is a leading cause of mortality and morbidity in the United States. Nutritional, lifestyle, hormonal, and other biologic factors are thought to be responsible for the increased chronic disease risk in women. Baseline dietary intake was measured by food frequency questionnaires and repeated 24-hour recalls in 275 premenopausal women. Data were used to evaluate adherence to 10 cancer prevention recommendations as outlined by the World Cancer Research Fund/American Institute of Cancer Research (WCRF/AICR). The association between adherence and known chronic disease biomarkers was also assessed. WCRF/AICR recommendations were operationalized into eight scores related to body fatness, physical activity, dietary intake, and smoking status. These scores were compared with mammographic density and nipple aspirate fluid as well as biologic markers for chronic diseases found in serum (estrogens, insulin-like growth factor, C-reactive protein and γ-tocopherol) and urine (estrogens and F2-isoprostane).
Results from Analysis of Variance detected weak associations with WCRF/AICR recommendations and the measured biomarkers. Analysis between BMI status and biomarker levels suggested obese women have higher levels of serum C-reactive protein (LS mean of 0.9 mg/L) compared to normal and overweight women (2.3 vs. 4.6 mg/L, respectively; p<0.0001). Obese women also had higher γ-tocopherol (LS mean of 1502 ng/mL) compared to normal and overweight women (1777 vs. 1988 ng/mL, respectively; p=0.02). Significant positive and inverse associations were also observed between both alcohol and red meat consumption and the majority of the biomarkers measured γ-tocopherol showed the most association of any biomarker with dietary intake. Additional research is needed in the area of nutrition and biomarkers to understand, which biomarkers may be influenced and how these associations relate to health outcomes. Findings from this study reinforce that biomarkers may be particularly beneficial in understanding the role overweight and obesity plays in the interaction between diet and disease.
Subjects/Keywords: Chronic; disease
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Beckford, F. Z. (2015). Are world cancer research fund and american institute for cancer research recommendations for cancer prevention associated with known chronic disease biomarkers in healthy women?. (Thesis). University of Hawaii – Manoa. Retrieved from http://hdl.handle.net/10125/100293
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Beckford, Fanchon Z. “Are world cancer research fund and american institute for cancer research recommendations for cancer prevention associated with known chronic disease biomarkers in healthy women?.” 2015. Thesis, University of Hawaii – Manoa. Accessed February 18, 2020.
http://hdl.handle.net/10125/100293.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Beckford, Fanchon Z. “Are world cancer research fund and american institute for cancer research recommendations for cancer prevention associated with known chronic disease biomarkers in healthy women?.” 2015. Web. 18 Feb 2020.
Vancouver:
Beckford FZ. Are world cancer research fund and american institute for cancer research recommendations for cancer prevention associated with known chronic disease biomarkers in healthy women?. [Internet] [Thesis]. University of Hawaii – Manoa; 2015. [cited 2020 Feb 18].
Available from: http://hdl.handle.net/10125/100293.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Beckford FZ. Are world cancer research fund and american institute for cancer research recommendations for cancer prevention associated with known chronic disease biomarkers in healthy women?. [Thesis]. University of Hawaii – Manoa; 2015. Available from: http://hdl.handle.net/10125/100293
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Nottingham
2.
Goldberg, Sarah.
Confused older patients' experiences of care on a specialist medical and mental health unit compared with standard care wards.
Degree: PhD, 2012, University of Nottingham
URL: http://eprints.nottingham.ac.uk/13107/
;
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.570387
► There are concerns about cognitively impaired older patients’ experiences of general hospital care. Nottingham University Hospital developed a medical and mental health unit (MMHU) as…
(more)
▼ There are concerns about cognitively impaired older patients’ experiences of general hospital care. Nottingham University Hospital developed a medical and mental health unit (MMHU) as a demonstration model of best practice dementia care. This thesis describes a controlled clinical trial comparing patients’ experiences of care on the MMHU to standard care wards. Patient experience was measured using the structured non-participant observational tool Dementia Care Mapping. Observations lasted 6 hours during which a score was recorded every five minutes for the patient’s mood and engagement and activity, together with incidents of enhancing and detracting staff behaviours. Noise (alarms, background noise and co-patients calling out) was recorded. 90 (46 MMHU, 44 Standard care) patients were observed between March and December 2011. At admission, most characteristics of patients on MMHU and standard care were similar. However, patients observed on MMHU had more behaviour disturbance, more often were care home residents and were less disabled than those observed on standard care. Patients on MMHU experienced a median 11% (95% Confidence Interval (CI) 2%, 20%) improvement in the proportion of time in positive mood and engagement (79% versus 68%); a median 3 (95%CI 1, 5) more enhancers (4 versus 1); a median 13% (95%CI -17%, -7%) less time noise could be heard (79% versus 92%) but a median 15% (95%CI 1, 23%) increase in proportion of time co-patients called out (21% versus 6%). Patients on MMHU had a better experience of care than those on standard care wards in terms of their mood and engagement, number of enhancers and improved noise levels, but experienced more co-patients calling out. This is the first study measuring an intervention to improve cognitively impaired older patients’ experiences in the general hospital and the first study to use the Dementia Care Mapping tool to evaluate an intervention in this setting.
Subjects/Keywords: 362.19897; WT Geriatrics. Chronic disease
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Goldberg, S. (2012). Confused older patients' experiences of care on a specialist medical and mental health unit compared with standard care wards. (Doctoral Dissertation). University of Nottingham. Retrieved from http://eprints.nottingham.ac.uk/13107/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.570387
Chicago Manual of Style (16th Edition):
Goldberg, Sarah. “Confused older patients' experiences of care on a specialist medical and mental health unit compared with standard care wards.” 2012. Doctoral Dissertation, University of Nottingham. Accessed February 18, 2020.
http://eprints.nottingham.ac.uk/13107/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.570387.
MLA Handbook (7th Edition):
Goldberg, Sarah. “Confused older patients' experiences of care on a specialist medical and mental health unit compared with standard care wards.” 2012. Web. 18 Feb 2020.
Vancouver:
Goldberg S. Confused older patients' experiences of care on a specialist medical and mental health unit compared with standard care wards. [Internet] [Doctoral dissertation]. University of Nottingham; 2012. [cited 2020 Feb 18].
Available from: http://eprints.nottingham.ac.uk/13107/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.570387.
Council of Science Editors:
Goldberg S. Confused older patients' experiences of care on a specialist medical and mental health unit compared with standard care wards. [Doctoral Dissertation]. University of Nottingham; 2012. Available from: http://eprints.nottingham.ac.uk/13107/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.570387
University of Nottingham
3.
Gribbin, Jonathan.
Falls in older people and the role of commonly prescribed antidepressant and antihypertensive medications.
Degree: PhD, 2013, University of Nottingham
URL: http://eprints.nottingham.ac.uk/28451/
;
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.594820
► Background Falls in older people result in harm for individuals and are a major public health problem, but there is little published data on the…
(more)
▼ Background Falls in older people result in harm for individuals and are a major public health problem, but there is little published data on the recording and incidence of falls seen in primary care, with which to consider the implications of recent policy initiatives. A range of factors contribute to falls risk. Amongst these, the role of some medications is well established, but the evidence base regarding the effects of some of the most commonly prescribed medications remains meagre and inconsistent. Aims The project aims to quantify the overall incidence and distribution of recorded falls among older people in primary care in the UK, and the associated risk of death. The falls risk profile of more recently introduced serotonin noradrenalin reuptake inhibitors (SNRls) is explored to assess whether it is more favourable than that of selective serotonin reuptake inhibitors (SSRls). Similarly, prescribing of subclasses of antihypertensive medication is explored to establish whether any of them modify risk of falling. Finally, other classes or sub-classes of medication prescribed in primary care are identified whose apparent falls risk warrants further investigation. Methods Analysis of falls and prescribing history in the electronic records of patients aged 60 years and over from The Health Improvement Network (THIN) using cohort, survival, case-control and case series study designs. Results Amongst people aged >60 years the overall crude incidence rate of recorded falls was 3.58/100 person-years (3.56-3.61), higher in older age groups, in women and least advantaged social groups, and was constant in the period 2003-2006. Fallers experienced a substantial increase in mortality (two-fold increase for recurrent fallers, and more than five-fold for those aged 60-74 years). This increase is independent of fractures recorded at the time of the fall or subsequently. People who fall have an increased rate of subsequent fracture (approximately three-fold and, for recurrent fallers aged 60-74 years more than eight-fold). There was an increased risk of current prescribing of SNRls (adjusted OR 1.79, 1.42 - 2.25) in first fall cases compared with controls. This was similar in magnitude to that seen with tricyclic antidepressants and SSRls. The increase in risk was apparent within the first 28 days after first prescription. The effects were also apparent in the self-controlled case series analysis: the incidence risk ratio for the period 1-28 days after initiation of treatment compared with unexposed periods was 1.49 (1.15 - 1.93). There was an increased risk of current prescribing of thiazides (adjusted OR 1.28, 1.16-1.42). At 3 weeks after first prescribing the adjusted risk remained 4.28 (1.19-15.42). In the case series analysis the incidence risk ratio for the period 21 days after first prescription was 2.80 (1.7 - 4.57). We found a reduced risk for current prescribing of beta blockers (adjusted OR 0.90; 0.85- 0.96), but a weakly positive effect in the case series analysis for the corresponding period IRR 1.23 (1.02-1.48).…
Subjects/Keywords: 617.20846; WT Geriatrics. Chronic disease
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Gribbin, J. (2013). Falls in older people and the role of commonly prescribed antidepressant and antihypertensive medications. (Doctoral Dissertation). University of Nottingham. Retrieved from http://eprints.nottingham.ac.uk/28451/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.594820
Chicago Manual of Style (16th Edition):
Gribbin, Jonathan. “Falls in older people and the role of commonly prescribed antidepressant and antihypertensive medications.” 2013. Doctoral Dissertation, University of Nottingham. Accessed February 18, 2020.
http://eprints.nottingham.ac.uk/28451/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.594820.
MLA Handbook (7th Edition):
Gribbin, Jonathan. “Falls in older people and the role of commonly prescribed antidepressant and antihypertensive medications.” 2013. Web. 18 Feb 2020.
Vancouver:
Gribbin J. Falls in older people and the role of commonly prescribed antidepressant and antihypertensive medications. [Internet] [Doctoral dissertation]. University of Nottingham; 2013. [cited 2020 Feb 18].
Available from: http://eprints.nottingham.ac.uk/28451/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.594820.
Council of Science Editors:
Gribbin J. Falls in older people and the role of commonly prescribed antidepressant and antihypertensive medications. [Doctoral Dissertation]. University of Nottingham; 2013. Available from: http://eprints.nottingham.ac.uk/28451/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.594820
University of Nottingham
4.
Conroy, Simon.
Preventing falls in older people.
Degree: PhD, 2009, University of Nottingham
URL: http://eprints.nottingham.ac.uk/11058/
;
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.515585
► Falls are a major cause of injury fear of falling and death affecting 24% of older people annually. Falls have a major impact on hospital…
(more)
▼ Falls are a major cause of injury fear of falling and death affecting 24% of older people annually. Falls have a major impact on hospital services, are an important cause of carer strain and admission to long term care. Multifactorial interventions delivered to fallers are effective in reducing falls rates by 25%. However, no UK studies have evaluated the role of screening older people living in the community and offering those at high risk a falls prevention programme. This work describes two studies – the evaluation of a postal falls risk screening tool, and a randomised controlled trial assessing the benefits of offering a falls prevention programme to those identified as being at high risk. 335 older people were recruited into the screening study, using a modified version of the Falls Risk Assessment Tool. The sensitivity was 79%, specificity 58%, positive predictive value 50% and the negative predictive value 83%. In the RCT, 364 community-dwelling older people at high risk of falls were randomised into a pragmatic, multicentre trial evaluating falls prevention programmes. 181 were allocated to the control group and 183 to the intervention. The primary outcome was the rate of falls; the adjusted IRR was 0.73 (0.51-1.03), p=0.071. There were no significant differences between the groups in terms of the proportion of fallers, recurrent fallers, medically verified falls, injurious falls, time to first fall or time to second fall. Nor were there significant differences in terms of institutionalisation, mortality, basic or extended activities of daily living, or fear of falling. Further work on testing falls prevention interventions for acceptability is required, followed by a further adequately powered RCT to determine the clinical effectiveness of a systematic screening programme and intervention. At present, there is insufficient evidence for health care commissioners to recommend screening and intervention for falls.
Subjects/Keywords: 362.6; WT Geriatrics. Chronic disease
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Conroy, S. (2009). Preventing falls in older people. (Doctoral Dissertation). University of Nottingham. Retrieved from http://eprints.nottingham.ac.uk/11058/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.515585
Chicago Manual of Style (16th Edition):
Conroy, Simon. “Preventing falls in older people.” 2009. Doctoral Dissertation, University of Nottingham. Accessed February 18, 2020.
http://eprints.nottingham.ac.uk/11058/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.515585.
MLA Handbook (7th Edition):
Conroy, Simon. “Preventing falls in older people.” 2009. Web. 18 Feb 2020.
Vancouver:
Conroy S. Preventing falls in older people. [Internet] [Doctoral dissertation]. University of Nottingham; 2009. [cited 2020 Feb 18].
Available from: http://eprints.nottingham.ac.uk/11058/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.515585.
Council of Science Editors:
Conroy S. Preventing falls in older people. [Doctoral Dissertation]. University of Nottingham; 2009. Available from: http://eprints.nottingham.ac.uk/11058/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.515585
Loughborough University
5.
Sood, Sanjana.
Developing RNA diagnostics for studying healthy human ageing.
Degree: PhD, 2017, Loughborough University
URL: https://dspace.lboro.ac.uk/2134/24708
;
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.734158
► Developing strategies to cope with increase in the ageing population and age-related chronic diseases is one of the societies biggest challenges. The characteristics of the…
(more)
▼ Developing strategies to cope with increase in the ageing population and age-related chronic diseases is one of the societies biggest challenges. The characteristics of the ageing process shows significant inter-individual variation. Building genomic signatures that could account for variation in health outcomes with age may facilitate early prognosis of individual age-correlated diseases (e.g. cancer, coronary artery diseases and dementia) and help in developing better targeted treatments provided years in advance of acquiring disabling symptoms for these diseases. The aim of this thesis was to explore methods for diagnosing molecular features of human ageing. In particular, we utilise multi-platform transcriptomics, independent clinical data and classification methods to evaluate which human tissues demonstrate a reproducible molecular signature for age and which clinical phenotypes correlated with these new RNA biomarkers.
Subjects/Keywords: Ageing; Chronic disease; Bioinformatics; Genetics
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Sood, S. (2017). Developing RNA diagnostics for studying healthy human ageing. (Doctoral Dissertation). Loughborough University. Retrieved from https://dspace.lboro.ac.uk/2134/24708 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.734158
Chicago Manual of Style (16th Edition):
Sood, Sanjana. “Developing RNA diagnostics for studying healthy human ageing.” 2017. Doctoral Dissertation, Loughborough University. Accessed February 18, 2020.
https://dspace.lboro.ac.uk/2134/24708 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.734158.
MLA Handbook (7th Edition):
Sood, Sanjana. “Developing RNA diagnostics for studying healthy human ageing.” 2017. Web. 18 Feb 2020.
Vancouver:
Sood S. Developing RNA diagnostics for studying healthy human ageing. [Internet] [Doctoral dissertation]. Loughborough University; 2017. [cited 2020 Feb 18].
Available from: https://dspace.lboro.ac.uk/2134/24708 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.734158.
Council of Science Editors:
Sood S. Developing RNA diagnostics for studying healthy human ageing. [Doctoral Dissertation]. Loughborough University; 2017. Available from: https://dspace.lboro.ac.uk/2134/24708 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.734158
6.
Collins, Megan A.S.
Art’s Ability to Illuminate the Biopsychosocial-Cultural-Spiritual Impact of Living with a Chronic Medical Disease.
Degree: MA, Marital and Family Therapy, 2012, Loyola Marymount University
URL: http://digitalcommons.lmu.edu/etd/98
► This study sought to examine art’s ability to illuminate the biopsychosocial-cultural- spiritual impact of chronic medical disease. Chronic disease participants were self- selected and…
(more)
▼ This study sought to examine art’s ability to illuminate the biopsychosocial-cultural- spiritual impact of
chronic medical
disease.
Chronic disease participants were self- selected and consisted of clinical supervisors, staff, and psychotherapy interns at a community-based mental health clinic in Los Angeles. Quantitative questionnaire data and art-based response data, both imagery and word descriptions, were examined. Data analysis combined with the synthesized literature revealed the complex biopsychosocial- cultural-spiritual interactions and interdependencies with
chronic disease management. Findings supported art-based data’s potential to complement quantitative questionnaire data by providing additional insights into a holistic lived experience. Art and word analysis revealed themes and identified factors such as shame, uncertainty, and isolation, which affect health-related quality of life and treatment compliance. This research demonstrated arts-based data’s potential as a holistic healing, revealing, and diagnostic tool and exposes the need for further research into the benefits of integrating art therapy and including art-based data in the treatment and assessment of
chronic disease.
Keywords: chronic, persistent, medical
disease, illness, syndrome, condition, disability, art as therapy, art therapy, creative arts therapy, art expression, arts-based research, clinical art psychotherapy, holistic questionnaire, art directive, art, adherence, compliance, biopsychosocial, biological, psychological, social, socio-environmental, cultural, spiritual, diabetes, asthma, cancer, medical model, medical art therapy, evidenced-based practice, complementary and alternative therapy, hospital, inpatient, outpatient.
Advisors/Committee Members: Anthony Bodlovic.
Subjects/Keywords: Art Therapy; Chronic Disease
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Collins, M. A. S. (2012). Art’s Ability to Illuminate the Biopsychosocial-Cultural-Spiritual Impact of Living with a Chronic Medical Disease. (Masters Thesis). Loyola Marymount University. Retrieved from http://digitalcommons.lmu.edu/etd/98
Chicago Manual of Style (16th Edition):
Collins, Megan A S. “Art’s Ability to Illuminate the Biopsychosocial-Cultural-Spiritual Impact of Living with a Chronic Medical Disease.” 2012. Masters Thesis, Loyola Marymount University. Accessed February 18, 2020.
http://digitalcommons.lmu.edu/etd/98.
MLA Handbook (7th Edition):
Collins, Megan A S. “Art’s Ability to Illuminate the Biopsychosocial-Cultural-Spiritual Impact of Living with a Chronic Medical Disease.” 2012. Web. 18 Feb 2020.
Vancouver:
Collins MAS. Art’s Ability to Illuminate the Biopsychosocial-Cultural-Spiritual Impact of Living with a Chronic Medical Disease. [Internet] [Masters thesis]. Loyola Marymount University; 2012. [cited 2020 Feb 18].
Available from: http://digitalcommons.lmu.edu/etd/98.
Council of Science Editors:
Collins MAS. Art’s Ability to Illuminate the Biopsychosocial-Cultural-Spiritual Impact of Living with a Chronic Medical Disease. [Masters Thesis]. Loyola Marymount University; 2012. Available from: http://digitalcommons.lmu.edu/etd/98
7.
Prabakar, S.
Problems of people living with chronic disease: a
sociological analysis; -.
Degree: Sociology, 2010, Pondicherry University
URL: http://shodhganga.inflibnet.ac.in/handle/10603/5258
None
References p.233 249, Bibliography p.250 253,
Appendix p.254 260
Advisors/Committee Members: Ramathirtham, G.Subjects/Keywords: chronic disease
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Prabakar, S. (2010). Problems of people living with chronic disease: a
sociological analysis; -. (Thesis). Pondicherry University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/5258
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Prabakar, S. “Problems of people living with chronic disease: a
sociological analysis; -.” 2010. Thesis, Pondicherry University. Accessed February 18, 2020.
http://shodhganga.inflibnet.ac.in/handle/10603/5258.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Prabakar, S. “Problems of people living with chronic disease: a
sociological analysis; -.” 2010. Web. 18 Feb 2020.
Vancouver:
Prabakar S. Problems of people living with chronic disease: a
sociological analysis; -. [Internet] [Thesis]. Pondicherry University; 2010. [cited 2020 Feb 18].
Available from: http://shodhganga.inflibnet.ac.in/handle/10603/5258.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Prabakar S. Problems of people living with chronic disease: a
sociological analysis; -. [Thesis]. Pondicherry University; 2010. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/5258
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Nottingham
8.
Gordon, Adam L.
Does Comprehensive Geriatric Assessment (CGA) have a role in UK care homes?.
Degree: 2012, University of Nottingham
URL: http://eprints.nottingham.ac.uk/12619/
;
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.559594
► UK care home residents are frail, dependent and multimorbid. General practitioners (GPs) provide their healthcare but there is evidence that existing provision fails to meet…
(more)
▼ UK care home residents are frail, dependent and multimorbid. General practitioners (GPs) provide their healthcare but there is evidence that existing provision fails to meet their needs. Comprehensive Geriatric Assessment (CGA) comprises comprehensive multidisciplinary assessment, goal setting and frequent review. This thesis considers a possible role for CGA in UK care homes through three research projects. The Care Home Literature Review (CHoLiR) was a systematic mapping review of randomized controlled trials (RCTs) in care homes. It found no evidence supporting CGA as a whole but described some CGA components supported by RCTs: advanced care planning; interventions to reduce prescribing; staff education around dementia and end-of-life; calcium/vitamin D and alendronate in preventing fractures and osteoporosis; vaccination/neuraminidase inhibitors in preventing influenza; functional incidental and bladder training for incontinence; and risperidone/olanzapine for agitation. The Care Home Outcome Study (CHOS) was a longitudinal cohort study recording dependency, cognition, behaviour, diagnoses, prescribing, nutrition and healthcare resource use in 227 residents across 11 care homes over six months. It reported high levels of dependency, cognitive impairment, malnutrition, multimorbidity and frequent behavioural disturbance. Polypharmacy and prescribing errors were common. Variability between homes and individuals was significant for most baseline and outcome measures. Staff Interviews in Care Homes (STICH) was a qualitative interview study of 32 staff working with care homes including: GPs; care home managers and nurses; NHS community nurses and specialist practitioners. It described care defined by discontinuity and lack-of-anticipation; driven by communication failure, inadequate training and expertise in frail older patients, and arbitrary boundaries between care homes and the NHS which interfered with care. Using the findings of these studies, the author proposes a model of care which is multidisciplinary, guided by comprehensive assessment, reinforced by frequent review and delivered by experts in the care of frail older patients: CGA has a role in UK care homes.
Subjects/Keywords: 362.61; WT Geriatrics. Chronic disease
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Gordon, A. L. (2012). Does Comprehensive Geriatric Assessment (CGA) have a role in UK care homes?. (Doctoral Dissertation). University of Nottingham. Retrieved from http://eprints.nottingham.ac.uk/12619/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.559594
Chicago Manual of Style (16th Edition):
Gordon, Adam L. “Does Comprehensive Geriatric Assessment (CGA) have a role in UK care homes?.” 2012. Doctoral Dissertation, University of Nottingham. Accessed February 18, 2020.
http://eprints.nottingham.ac.uk/12619/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.559594.
MLA Handbook (7th Edition):
Gordon, Adam L. “Does Comprehensive Geriatric Assessment (CGA) have a role in UK care homes?.” 2012. Web. 18 Feb 2020.
Vancouver:
Gordon AL. Does Comprehensive Geriatric Assessment (CGA) have a role in UK care homes?. [Internet] [Doctoral dissertation]. University of Nottingham; 2012. [cited 2020 Feb 18].
Available from: http://eprints.nottingham.ac.uk/12619/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.559594.
Council of Science Editors:
Gordon AL. Does Comprehensive Geriatric Assessment (CGA) have a role in UK care homes?. [Doctoral Dissertation]. University of Nottingham; 2012. Available from: http://eprints.nottingham.ac.uk/12619/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.559594
9.
Alderson, Helen.
Investigation of chronic kidney disease related
biomarkers in association with clinical characteristics and
outcomes in a large prospective CKD cohort.
Degree: 2017, University of Manchester
URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:307086
► Chronic Kidney Disease (CKD) is common and is associated with increased risk of progression to end stage renal disease, cardiovascular disease and death. CKD is…
(more)
▼ Chronic Kidney
Disease (CKD) is common and is
associated with increased risk of progression to end stage renal
disease, cardiovascular
disease and death. CKD is a heterogeneous
condition and accurately predicting an individual’s risk for
adverse outcomes remains a challenge. Over the past decade there
has been a focus on the identification of novel biomarkers that may
help improve risk stratification and the prediction of clinical
endpoints in this population.The overall aim of this research
project was to investigate a series of novel biomarkers in patients
from the
Chronic Renal Insufficiency Standards Implementation Study
(CRISIS), a prospective observational study of outcome in all cause
non-dialysis dependent CKD 3-5. The biomarkers selected for this
project were Anti-Apolipoprotein A-1 (Anti-apoA-1 IgG), fetuin-A,
fibroblast growth factor-23 (FGF23), high sensitivity cardiac
troponin T (HS-cTnT), kidney injury molecule-1 (KIM-1), N-terminal
pro-brain natriuretic peptide (NT-proBNP), neutrophil gelatinase
associated lipocalin (NGAL) and osteoprotegerin (OPG). These
biomarkers were chosen to address the three clinical endpoints of
progression, cardiovascular
disease and death with biomarkers
considered both individually and as groups of related markers.The
first aim of this project was to examine associations between the
novel biomarkers and the clinical characteristics of the CRISIS
population. The second aim was to investigate the associations
between novel biomarkers and the study endpoints. In the case of
FGF23 longitudinal measurements were analysed and in all other
cases associations between baseline levels of the markers and
clinical outcomes were considered. The third aim was to consider
whether the biomarkers investigated in this project actually
improve parameters of risk stratification and model discrimination,
thereby demonstrating a potential to improve the prediction of
outcome events in the CKD population.Many of the biomarkers were
independently associated with one or all of the clinical outcomes
considered. Despite these associations, it was more difficult to
demonstrate clear improvement in risk classification or the
prediction of clinical endpoints. Baseline models of standard
biochemical and clinical parameters performed very well so even
biomarkers that were strongly associated with clinical outcomes
resulted in only small incremental improvements in the prediction
of outcome events. It is now important to focus on defining how
biomarkers may fit into clinical decision
pathways.
Advisors/Committee Members: MIDDLETON, RACHEL RJ, Kalra, Philip, Middleton, Rachel.
Subjects/Keywords: Biomarkers; Chronic Kidney Disease; Outcomes
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Alderson, H. (2017). Investigation of chronic kidney disease related
biomarkers in association with clinical characteristics and
outcomes in a large prospective CKD cohort. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:307086
Chicago Manual of Style (16th Edition):
Alderson, Helen. “Investigation of chronic kidney disease related
biomarkers in association with clinical characteristics and
outcomes in a large prospective CKD cohort.” 2017. Doctoral Dissertation, University of Manchester. Accessed February 18, 2020.
http://www.manchester.ac.uk/escholar/uk-ac-man-scw:307086.
MLA Handbook (7th Edition):
Alderson, Helen. “Investigation of chronic kidney disease related
biomarkers in association with clinical characteristics and
outcomes in a large prospective CKD cohort.” 2017. Web. 18 Feb 2020.
Vancouver:
Alderson H. Investigation of chronic kidney disease related
biomarkers in association with clinical characteristics and
outcomes in a large prospective CKD cohort. [Internet] [Doctoral dissertation]. University of Manchester; 2017. [cited 2020 Feb 18].
Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:307086.
Council of Science Editors:
Alderson H. Investigation of chronic kidney disease related
biomarkers in association with clinical characteristics and
outcomes in a large prospective CKD cohort. [Doctoral Dissertation]. University of Manchester; 2017. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:307086
10.
최, 정우.
Testosterone might be influenced by co-morbidities, not by aging.
Degree: 2014, Ajou University
URL: http://repository.ajou.ac.kr/handle/201003/10905
;
http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000016039
► 1) 연구배경: 일반적으로 테스토스테론은 나이가 들수록 감소한다고 알려져 있다. 하지만 최근의 연구에 따르면 테스토스테론의 감소 및 남성갱년기는 노화와의 연관성 보다는 만성질환을 포함한 다른 조건에 의할…
(more)
▼ 1) 연구배경: 일반적으로 테스토스테론은 나이가 들수록 감소한다고 알려져 있다. 하지만 최근의 연구에 따르면 테스토스테론의 감소 및 남성갱년기는 노화와의 연관성 보다는 만성질환을 포함한 다른 조건에 의할 것이라고 조심스럽게 언급되고 있다. 그러므로 본 연구는 남성호르몬에 영향을 주는 주요 인자 중 질환에 의한 영향을 알아보고자 한다.
2) 방법: 2008년부터 2013년까지 40세 이상의 남성 4,283명을 대상으로 질병군 및 정상군으로 나누어 총 테스토스테론을 포함한 혈액검사 및 임상자료를 두군간에 비교하였다.
3) 결과: 금번 연구에서 2,041명이 질병군(47.6%), 2,243명이 정상군(52.4%)이며 총 테스토스테론과 나이(r=0.032, P=0.034), HDL(r=0.133, P<0.001) 은 각각 양의 상관관계를 보이며, BMI(r=-0.198, P<0.001), 복부둘레(r=-0.184, P<0.001), 혈압, ALT(r=-0.132, P<0.001), 공복혈당(r=-0.105, P<0.001), TG(r=-0.119, P<0.001) 및 알부민(r=-0.108, P<0.001)은 각각 총 테스토스테론과 음의 상관관계를 보였다. 총 테스토스테론은 나이에 따라 증가하지 않았으며, 대사증후군, 고혈압, 및 당뇨병이 있는 사람들은 정상군에 비해 총 테스토스테론이 낮았다. 질병군이 남성갱년기에 이환될 확률이 정상군이 남성갱년기에 이환될 확률보다 1.595(95%CI, 1.355-1.876)배 높았다.
4) 결론: 정상군에서보다 질병군에서 총테스토스테론이 낮았다. 총테스토스테론은 나이가 아니라 질병에 의해 영향을 받는다.
1) Background: Total testosterone in men decreasing with age is well-established. However, observations on aging-related decrease in total testosterone (TT) are not consistent. The aim of this study is to seek the relationship between testosterone and health status and investigate the influence of the chronic disease to testosterone level.
2) Methods: A total of 4,284 aged ≥ 40 year old men were included between 2008 and 2013. The subjects divided to two groups (chronic disease group versus normal group). Blood tests results and clinical data, including serum total testosterone, were checked and compared between the groups.
3) Results: Our data showed that 2,041 subjects had chronic diseases (47.6%), and 2,243 were normal (52.4%). Total testosterone and age(r=0.032, P=0.034), HDL(r=0.133, P<0.001) had positive correlation, respectively. On the other hand, BMI(r=-0.198, P<0.001), waist circumference(r=-0.184, P<0.001), blood pressure, ALT(r=-0.132, P<0.001), fasting sugar(r=-0.105, P<0.001), Triglyceride(r=-0.119, P<0.001) and albumin(r=-0.108, P<0.001) showed negative correlation with total testosterone, respectively. Total testosterone level did not decrease with age. People who had metabolic syndrome, hypertension and diabetes were had lower total testosterone than normal population. Odds ratio of the hypogonadism in chronic disease group compared to normal group was 1.595(95% CI, 1.355-1.876, P<0.001).
4) Conclusion: The total testosterone level was lower in chronic disease group compared to healthy subjects. Total testosterone level influenced by disease status, not by aging.
ABSTRACT ⅰ
TABLE OF CONTENTS ⅱ
LIST OF FIGURES ⅲ
LIST OF TABLES ⅳ
Ⅰ. INTRODUCTION 1
Ⅱ. MATERIALS AND METHODS 3
Ⅲ. RESULTS 5
Ⅳ. DISCUSSION 11
Ⅴ. CONCLUSION 13
REFEENCES 14
국문요약 16
Master
Advisors/Committee Members: 201224122, 최, 정우.
Subjects/Keywords: Testosterone; Chronic disease; Hypogonadism; Aging
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
최, . (2014). Testosterone might be influenced by co-morbidities, not by aging. (Thesis). Ajou University. Retrieved from http://repository.ajou.ac.kr/handle/201003/10905 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000016039
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
최, 정우. “Testosterone might be influenced by co-morbidities, not by aging.” 2014. Thesis, Ajou University. Accessed February 18, 2020.
http://repository.ajou.ac.kr/handle/201003/10905 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000016039.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
최, 정우. “Testosterone might be influenced by co-morbidities, not by aging.” 2014. Web. 18 Feb 2020.
Vancouver:
최 . Testosterone might be influenced by co-morbidities, not by aging. [Internet] [Thesis]. Ajou University; 2014. [cited 2020 Feb 18].
Available from: http://repository.ajou.ac.kr/handle/201003/10905 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000016039.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
최 . Testosterone might be influenced by co-morbidities, not by aging. [Thesis]. Ajou University; 2014. Available from: http://repository.ajou.ac.kr/handle/201003/10905 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000016039
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Nottingham
11.
Bramley, Louise.
One day at a time : living with frailty : implications for the practice of advance care planning : a multiple case study.
Degree: PhD, 2016, University of Nottingham
URL: http://eprints.nottingham.ac.uk/33400/
;
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.689929
► Background: Advance care planning (ACP) was originally designed to promote autonomy and is commonly conceptualised as informing treatment and decisions in the event of a…
(more)
▼ Background: Advance care planning (ACP) was originally designed to promote autonomy and is commonly conceptualised as informing treatment and decisions in the event of a person’s loss of capacity. In the UK, healthcare policy has emphasised the potential for ACP to significantly contribute to improvements in experiences of death and dying for patients and their significant others. Older people with progressive frailty are at high risk of mortality, loss of capacity and increasing dependency on carers and care services, yet uptake of ACP in this group is poor. Little is known about whether frail older people regard advance care planning as relevant or what perspectives they have on decision making for the future. Aim: To explore the expectations, experiences and understandings of frail older people and their significant others of planning for future care and to examine the implications of this for the practice of ACP. Methods: The study adopted an exploratory case study design using serial qualitative interviews and the responsive interview technique. Frail older people and their nominated carers were recruited from hospital wards in a large University Hospital NHS Trust prior to discharge. They took part in up to two interviews either in hospital or in their homes. Within and cross-case qualitative analysis was undertaken. Findings: Sixteen frail older people and eight significant others were recruited (Seventeen female, seven male, age range 70-96). The study found that frail older people experience profound uncertainty, associated with rapid changes to their physical and/or mental state and complex challenges in everyday life. Consequently, their attention is focused on day-to-day maintenance of quality of life, rather than on future care or advance decision making. Many had difficulty imagining a future; as dependency grew, so did reliance on care services to support their needs. What once would have been deemed an unacceptable way of living became routine. For many, the care system offers a lifeline without which they would not be able to exist at home. However, it also appeared to offer little individual flexibility, meaning that frail older people struggled to assert the control over day-to-day decisions and choices that others take for granted. This increasing dependency and reliance on care and care services has the potential to undermine the decision-making capacity of frail older people. For many, autonomous choice and decision making gave way to relationships, partnerships and negotiations that are commensurate with a more relational model of autonomy. Conclusion: The end-of-life orientation of current ACP policy and practice is at odds with the dynamic nature of frailty and does not correspond to individuals’ needs to maximise their current quality of life. The liberal ideal of autonomy as self-determination and self-interest presented by the legalistic and ideologically driven policy of ACP is out of step with the lived worlds of frail older people. For those facing increasing dependency on care and care…
Subjects/Keywords: 362.61; WT Geriatrics. Chronic disease
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Bramley, L. (2016). One day at a time : living with frailty : implications for the practice of advance care planning : a multiple case study. (Doctoral Dissertation). University of Nottingham. Retrieved from http://eprints.nottingham.ac.uk/33400/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.689929
Chicago Manual of Style (16th Edition):
Bramley, Louise. “One day at a time : living with frailty : implications for the practice of advance care planning : a multiple case study.” 2016. Doctoral Dissertation, University of Nottingham. Accessed February 18, 2020.
http://eprints.nottingham.ac.uk/33400/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.689929.
MLA Handbook (7th Edition):
Bramley, Louise. “One day at a time : living with frailty : implications for the practice of advance care planning : a multiple case study.” 2016. Web. 18 Feb 2020.
Vancouver:
Bramley L. One day at a time : living with frailty : implications for the practice of advance care planning : a multiple case study. [Internet] [Doctoral dissertation]. University of Nottingham; 2016. [cited 2020 Feb 18].
Available from: http://eprints.nottingham.ac.uk/33400/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.689929.
Council of Science Editors:
Bramley L. One day at a time : living with frailty : implications for the practice of advance care planning : a multiple case study. [Doctoral Dissertation]. University of Nottingham; 2016. Available from: http://eprints.nottingham.ac.uk/33400/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.689929
Mississippi State University
12.
Grant, Joshua.
The development of a model for vascular calcification and the effects of magnesium supplementation on <i>in vitro</i> calcification.
Degree: MS, Agricultural and Biological Engineering, 2015, Mississippi State University
URL: http://sun.library.msstate.edu/ETD-db/theses/available/etd-10292015-215744/
;
► Cardiovascular disease is most deadly medical condition in the United States. Medial vascular calcification is a disease that often precedes other more serious cardiovascular…
(more)
▼ Cardiovascular
disease is most deadly medical condition in the United States. Medial vascular calcification is a
disease that often precedes other more serious cardiovascular diseases that have high mortality. In order to research new therapies for the treatment of medial vascular calcification, an <i>in vitro</i> cell culture model must be developed that mimics the process <i>in vivo</i>. This
disease is shown to be an active, cell-mediated process where the vascular smooth muscle cells (VSMCs) in the arteries are differentiating into osteoblast-like cells and depositing hydroxyapatite mineral in the artery walls. By administering inorganic phosphate to cell culture medium, an osteogenic shift can initiated in VSMCs <i>in vitro</i> resulting in calcium deposition and an increase in bone related proteins. We propose to develop and characterize a model for vascular calcification and investigate the effects of magnesium supplementation on <i>in vitro</i> calcification and cellular phosphate uptake.
Advisors/Committee Members: Chartrisa LaShan Simpson (chair), Jun Liao (committee member), George Eli Howell III (committee member), Steven H. Elder (committee member).
Subjects/Keywords: Chronic Kidney Disease; Osteogenic Differentiation
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Grant, J. (2015). The development of a model for vascular calcification and the effects of magnesium supplementation on <i>in vitro</i> calcification. (Masters Thesis). Mississippi State University. Retrieved from http://sun.library.msstate.edu/ETD-db/theses/available/etd-10292015-215744/ ;
Chicago Manual of Style (16th Edition):
Grant, Joshua. “The development of a model for vascular calcification and the effects of magnesium supplementation on <i>in vitro</i> calcification.” 2015. Masters Thesis, Mississippi State University. Accessed February 18, 2020.
http://sun.library.msstate.edu/ETD-db/theses/available/etd-10292015-215744/ ;.
MLA Handbook (7th Edition):
Grant, Joshua. “The development of a model for vascular calcification and the effects of magnesium supplementation on <i>in vitro</i> calcification.” 2015. Web. 18 Feb 2020.
Vancouver:
Grant J. The development of a model for vascular calcification and the effects of magnesium supplementation on <i>in vitro</i> calcification. [Internet] [Masters thesis]. Mississippi State University; 2015. [cited 2020 Feb 18].
Available from: http://sun.library.msstate.edu/ETD-db/theses/available/etd-10292015-215744/ ;.
Council of Science Editors:
Grant J. The development of a model for vascular calcification and the effects of magnesium supplementation on <i>in vitro</i> calcification. [Masters Thesis]. Mississippi State University; 2015. Available from: http://sun.library.msstate.edu/ETD-db/theses/available/etd-10292015-215744/ ;
Kansas State University
13.
Vaske, Heather.
Assessment of
renal function in hyperthyroid cats managed with a controlled
iodine diet.
Degree: MS, Department of Clinical
Sciences, 2015, Kansas State University
URL: http://hdl.handle.net/2097/35273
► Hyperthyroidism is the most common endocrinopathy of geriatric cats and has physiologic effects on almost every organ in the body. It specifically affects the kidneys…
(more)
▼ Hyperthyroidism is the most common endocrinopathy of
geriatric cats and has physiologic effects on almost every organ in
the body. It specifically affects the kidneys by increasing renal
blood flow and glomerular filtration rate. In addition, activation
of the renin angiotensin aldosterone system (RAAS) is increased and
ultimately leads to efferent glomerular arteriole constriction and
potentially glomerular hypertension. The classic treatment
modalities for feline hyperthyroidism (anti-thyroid medication,
radioiodine or surgery) have been evaluated for their overall
effects on renal function. Studies have demonstrated that
glomerular filtration rate (GFR) declines and serum creatinine
increases with hyperthyroid treatment independent of the treatment
modality. Hill’s® Prescription Diet® y/d® Feline, a relatively new
dietary treatment modality for feline hyperthyroidism with
controlled iodine concentrations, reduced phosphorus and protein,
and increased omega-3 fatty acids, has been shown to significantly
decrease thyroid hormone levels. The research provided in this
report is the first evaluating the posttreatment effects of y/d®
Feline on renal function. In agreement with previous studies, our
research found that y/d® Feline resulted in a significant decrease
in thyroid hormone levels. However, in contrast to other treatment
modalities, y/d® Feline did not result in a significant decline in
GFR, and it did result in a significant decline in mean serum
creatinine concentration. These data indicate that y/d® Feline, as
a treatment for feline hyperthyroidism, does not have a negative
effect on renal function.
Advisors/Committee Members: Gregory F. Grauer.
Subjects/Keywords: Hyperthyroidism; Chronic
kidney disease
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Vaske, H. (2015). Assessment of
renal function in hyperthyroid cats managed with a controlled
iodine diet. (Masters Thesis). Kansas State University. Retrieved from http://hdl.handle.net/2097/35273
Chicago Manual of Style (16th Edition):
Vaske, Heather. “Assessment of
renal function in hyperthyroid cats managed with a controlled
iodine diet.” 2015. Masters Thesis, Kansas State University. Accessed February 18, 2020.
http://hdl.handle.net/2097/35273.
MLA Handbook (7th Edition):
Vaske, Heather. “Assessment of
renal function in hyperthyroid cats managed with a controlled
iodine diet.” 2015. Web. 18 Feb 2020.
Vancouver:
Vaske H. Assessment of
renal function in hyperthyroid cats managed with a controlled
iodine diet. [Internet] [Masters thesis]. Kansas State University; 2015. [cited 2020 Feb 18].
Available from: http://hdl.handle.net/2097/35273.
Council of Science Editors:
Vaske H. Assessment of
renal function in hyperthyroid cats managed with a controlled
iodine diet. [Masters Thesis]. Kansas State University; 2015. Available from: http://hdl.handle.net/2097/35273
Harvard University
14.
Brooks, Carolyn Jean.
Clinical, Community, and Epidemiologic Considerations for Addressing Racial/Ethnic Disparities in Chronic Disease.
Degree: Doctor of Science (SD), 2017, Harvard University
URL: http://nrs.harvard.edu/urn-3:HUL.InstRepos:42066969
► Advancing health equity requires explicit consideration of the factors that prevent the attainment of the highest level of health for all people. Racial/ethnic and socioeconomic…
(more)
▼ Advancing health equity requires explicit consideration of the factors that prevent the attainment of the highest level of health for all people. Racial/ethnic and socioeconomic disparities in chronic conditions such as obesity and hypertension persist. The U.S. Department of Health and Human Services’ Action Plan to Reduce Racial and Ethnic Health Disparities acknowledged the need to consider disparities in 1) health care access and quality, 2) community conditions that provide access to resources which support health, and in 3) adequate scientific data on race, ethnicity, and other factors that would help in understanding the barriers faced by groups experiencing disparities. This dissertation explores chronic disease disparities spanning clinical practice, community intervention, and epidemiologic surveillance. Chapter 1 answers the call of the Action Plan, by examining disparities in health care quality. Given well-documented racial/ethnic disparities in health care quality, and emerging evidence exploring the influence of weight bias and stigma on quality of care, we examined differences in obesity-related care in pediatric care settings by race/ethnicity and parent weight status. We found no evidence of consistent differences in obesity-related care by race/ethnicity or parent weight status after accounting for predictors that could influence care received. Chapter 2 examined the effectiveness of a community-level intervention in reducing the percent of high sodium (>200mg) prepackaged products in 21 institutions serving those disproportionately burdened by hypertension. After the intervention, the percent of high sodium prepackaged foods decreased significantly from 29.0% at baseline to 21.5% at follow-up. The change was primarily driven by sodium reductions in hospital cafeterias and kiosks. This study adds to the evidence-base of community-level sodium reduction initiatives. Chapter 3 examines trends and gaps in diet quality at the intersection of race/ethnicity with education and nativity. Diet quality scores have been low overall, with small improvements only for some population subgroups between 1999-2012. U.S.-born Blacks, regardless of education status, and others with lower levels of education experience the lowest diet quality scores, and are seeing the least amount of improvement over time. Nativity was also found to be an important factor that reveals distinct patterns in diet quality regardless of race/ethnicity.
Social and Behavioral Sciences
Advisors/Committee Members: Gortmaker, Steven (advisor), Taveras, Elsie (committee member), Williams, David (committee member).
Subjects/Keywords: racial/ethnic disparities; chronic disease
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Brooks, C. J. (2017). Clinical, Community, and Epidemiologic Considerations for Addressing Racial/Ethnic Disparities in Chronic Disease. (Doctoral Dissertation). Harvard University. Retrieved from http://nrs.harvard.edu/urn-3:HUL.InstRepos:42066969
Chicago Manual of Style (16th Edition):
Brooks, Carolyn Jean. “Clinical, Community, and Epidemiologic Considerations for Addressing Racial/Ethnic Disparities in Chronic Disease.” 2017. Doctoral Dissertation, Harvard University. Accessed February 18, 2020.
http://nrs.harvard.edu/urn-3:HUL.InstRepos:42066969.
MLA Handbook (7th Edition):
Brooks, Carolyn Jean. “Clinical, Community, and Epidemiologic Considerations for Addressing Racial/Ethnic Disparities in Chronic Disease.” 2017. Web. 18 Feb 2020.
Vancouver:
Brooks CJ. Clinical, Community, and Epidemiologic Considerations for Addressing Racial/Ethnic Disparities in Chronic Disease. [Internet] [Doctoral dissertation]. Harvard University; 2017. [cited 2020 Feb 18].
Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:42066969.
Council of Science Editors:
Brooks CJ. Clinical, Community, and Epidemiologic Considerations for Addressing Racial/Ethnic Disparities in Chronic Disease. [Doctoral Dissertation]. Harvard University; 2017. Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:42066969
University of California – San Francisco
15.
Low, Erik.
In a population of patients with compromised renal function, is there a correlation in periodontal status using systemic markers of eGFR, HbA1C, and serum albumin to creatinine ratio.
Degree: Oral and Craniofacial Sciences, 2015, University of California – San Francisco
URL: http://www.escholarship.org/uc/item/3rb9d6wp
► Purpose: The aim of this study is to investigate, in a population of patients with compromised renal function, is there a correlation in periodontal status…
(more)
▼ Purpose: The aim of this study is to investigate, in a population of patients with compromised renal function, is there a correlation in periodontal status using systemic markers of estimated glomerular filtration rate (eGFR), HbA1C, and serum albumin to creatinine ratio.Methods: Patients’ were screened for kidney disease and had to have an eGFR <60 ml/min/m2. They were also screened for periodontal disease and had to have been diagnosed with moderate/severe periodontal disease according to CDC/AAP guidelines and have 30% BOP. After patients’ met inclusion/exclusion criteria, a thorough periodontal exam was performed at baseline which included: probing depths (PD), gingival margin position (GM), clinical attachment level (CAL), plaque index (PI), gingival index (GI), and bleeding on probing (BOP) at six sites (MB, B, DB, DL, L, and ML) per tooth for every tooth. Additionally, blood and urine samples were taken at baseline as well to measure eGFR, HbA1c, and serum albumin to creatinine ratio. Simple statistics such as means, medians, and standard deviations were calculated for the entire population for both periodontal and kidney parameters. Also spearman rank correlations were calculated to determine if there were any associations between periodontal disease and chronic kidney disease. Lastly, surrogate markers of periodontal disease such as PD and CAL were stratified into categories to determine if there was any correlation with chronic kidney disease. Results: After applying the inclusion and exclusion criteria, 21 subjects entered the study. For correlation between kidney markers and periodontal markers, the eGFR was moderately positively correlated with average CAL (r = 0.46956, p ≤ 0.0317), and HBA1C (%) was moderately negatively associated with average PI (r = 0.51205, p ≤ 0.0176). When stratifying the data into PD and CAL categories, there were some differences that could be seen amongst the surrogate markers for chronic kidney disease, but none were statistically significant. Additionally, there was no statistically significant correlation between BOP % and markers of kidney function assessed in this study such as eGFR, HbA1c, and serum albumin to creatinine ratio %.Conclusions: There was no evidence in this study that supported the hypothesis that the severity of periodontal disease is correlated to the severity of chronic kidney disease and vice versa. The results of this study need to be interpreted with caution due to the small population (n = 21). Therefore, larger scale studies with more subjects, which look at populations more representative of the population as a whole, need to be conducted to determine if there is a correlation between periodontal disease and chronic kidney disease (CKD). Also, longitudinal studies of this magnitude need to be carried out to see if improvements of markers of one disease affect markers of the other.
Subjects/Keywords: Dentistry; Chronic kidney disease; Periodontics
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Low, E. (2015). In a population of patients with compromised renal function, is there a correlation in periodontal status using systemic markers of eGFR, HbA1C, and serum albumin to creatinine ratio. (Thesis). University of California – San Francisco. Retrieved from http://www.escholarship.org/uc/item/3rb9d6wp
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Low, Erik. “In a population of patients with compromised renal function, is there a correlation in periodontal status using systemic markers of eGFR, HbA1C, and serum albumin to creatinine ratio.” 2015. Thesis, University of California – San Francisco. Accessed February 18, 2020.
http://www.escholarship.org/uc/item/3rb9d6wp.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Low, Erik. “In a population of patients with compromised renal function, is there a correlation in periodontal status using systemic markers of eGFR, HbA1C, and serum albumin to creatinine ratio.” 2015. Web. 18 Feb 2020.
Vancouver:
Low E. In a population of patients with compromised renal function, is there a correlation in periodontal status using systemic markers of eGFR, HbA1C, and serum albumin to creatinine ratio. [Internet] [Thesis]. University of California – San Francisco; 2015. [cited 2020 Feb 18].
Available from: http://www.escholarship.org/uc/item/3rb9d6wp.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Low E. In a population of patients with compromised renal function, is there a correlation in periodontal status using systemic markers of eGFR, HbA1C, and serum albumin to creatinine ratio. [Thesis]. University of California – San Francisco; 2015. Available from: http://www.escholarship.org/uc/item/3rb9d6wp
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Illinois – Chicago
16.
Samp, Jennifer C.
Comparative Efficacy and Safety of Combination Treatments for Chronic Obstructive Pulmonary Disease.
Degree: 2017, University of Illinois – Chicago
URL: http://hdl.handle.net/10027/21925
► Background: Treatment with a long-acting beta2-agonist (LABA) is an integral part of the guidelines for management of chronic obstructive pulmonary disease (COPD). Concurrent use of…
(more)
▼ Background: Treatment with a long-acting beta2-agonist (LABA) is an integral part of the guidelines for management of
chronic obstructive pulmonary
disease (COPD). Concurrent use of a LABA and a long-acting muscarinic antagonist (LAMA) are believed to enhance bronchodilation due to the synergistic mechanisms of action. Only recently have fixed dose combination LABA/LAMA agents been developed which has resulted in a vast amount of efficacy and safety data from clinical trials. However, data remains lacking on the effectiveness and safety of LABA/LAMA in a broader population of COPD patients.
Objectives: The aims of this research were to examine real-world effectiveness and safety of LABA/LAMA compared to LABA/inhaled corticosteroid (LABA/ICS) combination treatment. A secondary goal was to develop a predictive model to identify those at risk for COPD exacerbations among patients treated with LABA/LAMA or LABA/ICS.
Methods: This was a retrospective, observational study utilizing administrative claims data among COPD patients initiating LABA/LAMA or LABA/ICS. Effectiveness was measured by comparing COPD exacerbation rates using Poisson regression models adjusted for baseline covariates. We examined cardiovascular and cerebrovascular safety outcomes by measuring hospitalizations with a primary diagnosis for acute coronary syndrome, heart failure, cardiac dysrhythmia, stroke, or transient ischemic attack. Time to event was compared using Cox proportional hazards models after matching patients 1 LABA/LAMA user to 4 LABA/ICS users) on propensity score. A predictive model of COPD exacerbations among LABA/LAMA or LABA/ICS users was developed using stepwise logistic regression in a training set of the original cohort. The test characteristics of the model were evaluated in the training set and validation set of patients.
Results: Patients treated with the LABA/LAMA combination had similar exacerbation rates compared to those treated with LABA/ICS (adjusted incidence rate ratio of 0.98 [95% CI: 0.95 – 1.01]). Cardiovascular events in the LABA/LAMA cohort were lower than LABA/ICS (hazard ratio [HR]=0.794 [95% CI: 0.623-0.997]) but there was no significant difference in the risk of cerebrovascular events (HR=1.166 [95% CI 0.653-1.959]). The base predictive model resulted in a sensitivity of 41.6% and specificity of 85.5%. Other exploratory models resulted in similar test characteristics.
Conclusions: In this real-world, observational study, exacerbations rates and cerebrovascular events were similar among patients treated with LABA/LAMA and LABA/ICS. Patients treated with LABA/LAMA had slightly lower risk of cardiovascular events. Further studies are recommended to confirm these findings. Finally, we were not able to develop a predictive model that identified patients at high risk for COPD exacerbations among patients treated with LABA/LAMA or LABA/ICS.
Advisors/Committee Members: Lee, Todd A (advisor), Joo, Min J (committee member), Schumock, Glen T (committee member), Pickard, A S (committee member), Calip, Gregory S (committee member), Lee, Todd A (chair).
Subjects/Keywords: Chronic obstructive pulmonary disease
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Samp, J. C. (2017). Comparative Efficacy and Safety of Combination Treatments for Chronic Obstructive Pulmonary Disease. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/21925
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Samp, Jennifer C. “Comparative Efficacy and Safety of Combination Treatments for Chronic Obstructive Pulmonary Disease.” 2017. Thesis, University of Illinois – Chicago. Accessed February 18, 2020.
http://hdl.handle.net/10027/21925.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Samp, Jennifer C. “Comparative Efficacy and Safety of Combination Treatments for Chronic Obstructive Pulmonary Disease.” 2017. Web. 18 Feb 2020.
Vancouver:
Samp JC. Comparative Efficacy and Safety of Combination Treatments for Chronic Obstructive Pulmonary Disease. [Internet] [Thesis]. University of Illinois – Chicago; 2017. [cited 2020 Feb 18].
Available from: http://hdl.handle.net/10027/21925.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Samp JC. Comparative Efficacy and Safety of Combination Treatments for Chronic Obstructive Pulmonary Disease. [Thesis]. University of Illinois – Chicago; 2017. Available from: http://hdl.handle.net/10027/21925
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Illinois – Chicago
17.
Hannan, Mary.
Cognitive Function, Physical Inactivity and Vascular Function in Older Adults with Chronic Kidney Disease.
Degree: 2019, University of Illinois – Chicago
URL: http://hdl.handle.net/10027/23705
► Introduction: Chronic kidney disease (CKD) is a common disease in older adults that is associated with numerous complications, including cognitive impairment and vascular dysfunction. Additionally,…
(more)
▼ Introduction:
Chronic kidney
disease (CKD) is a common
disease in older adults that is associated with numerous complications, including cognitive impairment and vascular dysfunction. Additionally, older adults have lifestyle factors that can negatively influence their health, including being sedentary. The purpose of this dissertation was to examine cognitive function, physical inactivity levels, and vascular function in older adults with and without CKD and to explore the relationships between these factors. Additionally, the relationship between cognitive function and vascular compliance and whether level of physical inactivity moderated this relationship was explored.
Methods: Utilizing a cross-sectional design, 48 older adults (24 with CKD, 24 without CKD) were evaluated for performance on a cognitive test of global cognition and executive function, vascular compliance via tonometry and ultrasound (carotid compliance and endothelial function), and physical inactivity with actigraphy. Data was analyzed utilizing OLS regression, Pearson’s correlations, and regression moderation analysis.
Results: Older adults with CKD had different levels of cognitive impairment, vascular dysfunction, and physical inactivity than older adults without CKD. In regression models including CKD and relevant covariates, the variance of cognitive function, indicators of regional arterial stiffness, some indicators of carotid compliance, and sedentary time per day were significantly explained.
With exploration, global cognitive function was found to be significantly correlated with carotid-femoral pulse wave velocity and an indicator of carotid artery compliance. Executive function scores were not found to be significantly correlated with vascular compliance in older adults with CKD. There was exploration into the potential moderating influence of sedentary time on the relationship between vascular compliance and cognitive function in older adults.
Conclusion: Cognitive impairment, some indicators of vascular function, and sedentary time appear to be different between older adults with and without CKD. With exploration, there was support of a potential relationship between vascular compliance and global cognitive function. Further investigation is needed into the moderating influence of sedentary time on the relationship between vascular function and cognitive impairment. There is a need for further exploration into the relationships between cognitive function, physical inactivity levels, and vascular function in older adults with and without CKD.
Advisors/Committee Members: Bronas, Ulf G (advisor), Collins, Eileen G (committee member), Phillips, Shane A (committee member), Quinn, Lauretta (committee member), Steffen, Alana (committee member), Bronas, Ulf G (chair).
Subjects/Keywords: Chronic kidney disease; Cognitive function
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Hannan, M. (2019). Cognitive Function, Physical Inactivity and Vascular Function in Older Adults with Chronic Kidney Disease. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/23705
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Hannan, Mary. “Cognitive Function, Physical Inactivity and Vascular Function in Older Adults with Chronic Kidney Disease.” 2019. Thesis, University of Illinois – Chicago. Accessed February 18, 2020.
http://hdl.handle.net/10027/23705.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Hannan, Mary. “Cognitive Function, Physical Inactivity and Vascular Function in Older Adults with Chronic Kidney Disease.” 2019. Web. 18 Feb 2020.
Vancouver:
Hannan M. Cognitive Function, Physical Inactivity and Vascular Function in Older Adults with Chronic Kidney Disease. [Internet] [Thesis]. University of Illinois – Chicago; 2019. [cited 2020 Feb 18].
Available from: http://hdl.handle.net/10027/23705.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Hannan M. Cognitive Function, Physical Inactivity and Vascular Function in Older Adults with Chronic Kidney Disease. [Thesis]. University of Illinois – Chicago; 2019. Available from: http://hdl.handle.net/10027/23705
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Guelph
18.
Cobrin, Allison.
Measurement of Serum and Urine Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Dogs with Chronic Kidney Disease, Lymphosarcoma, Carcinoma and Induced Endotoxemia to Assess Diagnostic Utility of NGAL in Dogs with Chronic Kidney Disease
.
Degree: 2013, University of Guelph
URL: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/7534
► Canine chronic kidney disease (CKD) is estimated to have a prevalence of 0.5-7%, and improved methods for the detection and monitoring of CKD are needed.…
(more)
▼ Canine
chronic kidney
disease (CKD) is estimated to have a prevalence of 0.5-7%, and improved methods for the detection and monitoring of CKD are needed. Neutrophil gelatinase-associated lipocalin (NGAL), a protein detectable in blood and urine that increases secondary to renal dysfunction, is gaining utility as a renal
disease biomarker in humans. The purpose of this study was to investigate serum and urine NGAL concentrations in normal dogs and dogs with naturally occurring CKD and then to assess the specificity by measuring serum and urine NGAL in dogs with other diseases.
Forty-two dogs assessed to be free of urinary tract
disease (normal history, physical examination, clinicopathologic results, and blood pressure measurement), 11 dogs with CKD, 21 dogs with lymphosarcoma, 12 dogs with carcinomas, and 16 dogs with induced endotoxemia were enrolled. Serum and urine NGAL concentrations were measured using a commercially available canine-specific ELISA kit.
Serum and urine NGAL levels were elevated in dogs with CKD compared to that of normal dogs. Concentrations of both correlated with serum creatinine concentration and with glomerular filtration rate at 6 months. Serum NGAL concentrations lacked specificity for CKD. Urine NGAL concentration was most elevated in dogs with CKD, followed by dogs with carcinomas and lymphosarcoma. Serum and urine NGAL concentrations are elevated in renal and non-renal diseases, but may still be useful adjunct to current methods to diagnose and monitor CKD.
Advisors/Committee Members: Blois, Shauna (advisor).
Subjects/Keywords: biomarkers;
canine;
chronic kidney disease
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Cobrin, A. (2013). Measurement of Serum and Urine Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Dogs with Chronic Kidney Disease, Lymphosarcoma, Carcinoma and Induced Endotoxemia to Assess Diagnostic Utility of NGAL in Dogs with Chronic Kidney Disease
. (Thesis). University of Guelph. Retrieved from https://atrium.lib.uoguelph.ca/xmlui/handle/10214/7534
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Cobrin, Allison. “Measurement of Serum and Urine Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Dogs with Chronic Kidney Disease, Lymphosarcoma, Carcinoma and Induced Endotoxemia to Assess Diagnostic Utility of NGAL in Dogs with Chronic Kidney Disease
.” 2013. Thesis, University of Guelph. Accessed February 18, 2020.
https://atrium.lib.uoguelph.ca/xmlui/handle/10214/7534.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Cobrin, Allison. “Measurement of Serum and Urine Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Dogs with Chronic Kidney Disease, Lymphosarcoma, Carcinoma and Induced Endotoxemia to Assess Diagnostic Utility of NGAL in Dogs with Chronic Kidney Disease
.” 2013. Web. 18 Feb 2020.
Vancouver:
Cobrin A. Measurement of Serum and Urine Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Dogs with Chronic Kidney Disease, Lymphosarcoma, Carcinoma and Induced Endotoxemia to Assess Diagnostic Utility of NGAL in Dogs with Chronic Kidney Disease
. [Internet] [Thesis]. University of Guelph; 2013. [cited 2020 Feb 18].
Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/7534.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Cobrin A. Measurement of Serum and Urine Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Dogs with Chronic Kidney Disease, Lymphosarcoma, Carcinoma and Induced Endotoxemia to Assess Diagnostic Utility of NGAL in Dogs with Chronic Kidney Disease
. [Thesis]. University of Guelph; 2013. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/7534
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Queens University
19.
Seyed Shobeiri, Navid.
The Pathogenesis of Vascular Calcification in Chronic Kidney Disease: Consequences and Treatments
.
Degree: Pharmacology and Toxicology, 2013, Queens University
URL: http://hdl.handle.net/1974/8498
► Vascular calcification (VC) is accelerated in patients with chronic kidney disease (CKD), resulting in increased risk of cardiovascular disease and mortality. Although the consequences of…
(more)
▼ Vascular calcification (VC) is accelerated in patients with chronic kidney disease (CKD), resulting in increased risk of cardiovascular disease and mortality. Although the consequences of VC are associated with elevated pulse wave velocity (PWV) and left ventricular hypertrophy (LVH), the temporal impact on blood pressure changes is unknown. Mineral imbalance in CKD greatly contributes to the development of VC, and elevated serum phosphate is a major risk factor. Magnesium, which plays an important role in bone regulation, has been recently shown to be a modifier of VC, but whether magnesium inhibits calcification in CKD is unknown.
A modified adenine model of CKD was developed in rats, characterized by mineral imbalance and progressive VC. During the development of VC, pulse pressure increased, which was driven by a drop in diastolic blood pressure, rather than systolic hypertension. Continuous pressure recordings in conscious rats using radiotelemetry revealed a significant increase in systolic variability associated with development of VC. Regional VC was associated with regional changes in the hemodynamic profile of the CKD rats. For example, only thoracic aortic calcification was associated with elevated PWV and pulse pressure. In contrast, the presence of abdominal and thoracic calcification differentially affected proximal and distal arterial pressure wave forms. CKD animals exhibited LVH, which was further increased by the presence of VC. In addition, fibroblast growth factor 23, which regulates renal excretion of phosphate, was elevated in CKD animals at every time point and was associated with LVH independently from VC. Development of VC was characterized in an in vitro organ model. Phosphate elevation in vitro caused VC in aortas. In vitro, magnesium supplementation inhibited initiation and progression of VC. CKD animals given a magnesium diet also demonstrated attenuated development of VC. In patients with stage 3-5 CKD (excluding dialysis), dietary phosphate was associated with the progression of coronary artery calcification even after adjusting for use of phosphate binders, total dietary energy and total dietary protein. Given the serious negative outcomes associated with development of VC, these findings fill key gaps in knowledge regarding the detection, management, prevention and treatment of VC in CKD.
Subjects/Keywords: Vascular Calcification;
Chronic Kidney Disease
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Seyed Shobeiri, N. (2013). The Pathogenesis of Vascular Calcification in Chronic Kidney Disease: Consequences and Treatments
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/8498
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Seyed Shobeiri, Navid. “The Pathogenesis of Vascular Calcification in Chronic Kidney Disease: Consequences and Treatments
.” 2013. Thesis, Queens University. Accessed February 18, 2020.
http://hdl.handle.net/1974/8498.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Seyed Shobeiri, Navid. “The Pathogenesis of Vascular Calcification in Chronic Kidney Disease: Consequences and Treatments
.” 2013. Web. 18 Feb 2020.
Vancouver:
Seyed Shobeiri N. The Pathogenesis of Vascular Calcification in Chronic Kidney Disease: Consequences and Treatments
. [Internet] [Thesis]. Queens University; 2013. [cited 2020 Feb 18].
Available from: http://hdl.handle.net/1974/8498.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Seyed Shobeiri N. The Pathogenesis of Vascular Calcification in Chronic Kidney Disease: Consequences and Treatments
. [Thesis]. Queens University; 2013. Available from: http://hdl.handle.net/1974/8498
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Queens University
20.
McCabe, Kristin.
The Role of Vitamin K in Vascular Calcification in a Rat Model of Chronic Kidney Disease
.
Degree: Pharmacology and Toxicology, 2015, Queens University
URL: http://hdl.handle.net/1974/12694
► Chronic kidney disease (CKD) affects approximately 3 million Canadians and these patients have a markedly increased risk of developing cardiovascular disease. CKD patients have abnormal…
(more)
▼ Chronic kidney disease (CKD) affects approximately 3 million Canadians and these patients have a markedly increased risk of developing cardiovascular disease. CKD patients have abnormal mineral metabolism and vitamin K status; dysfunctions that can accelerate the rate of vascular calcification. Matrix Gla protein (MGP) is a key tissue based inhibitor of calcification and is dependent on vitamin K for activity. In this thesis, an adenine-induced rat model of CKD was used to characterize quantitatively and temporally the impact of changing vitamin K status on the susceptibility of vessels to calcification. Treatment with the vitamin K antagonist warfarin, at therapeutic levels, significantly increased vessel calcification and the attendant circulatory consequences (higher pulse pressure and pulse wave velocity) whereas treatment with dietary vitamin K attenuated the pathogenesis. Vitamin K (K1) treatment increased the tissue levels of both forms of vitamin K (K1 and MK-4) in all the tissues studied. Vitamin K metabolism was clearly altered by CKD, in that there was a shift to lower K1 and higher MK-4 tissue content, resulting in an increased MK-4:K1 ratio. Although somewhat paradoxical, a decrease in the expression level of the MK-4 synthesizing enzyme UBIAD1 and the vitamin K recycling enzyme VKOR was found. This latter finding suggests that increased MK-4 was not due to an increase in production but rather to a decrease in utilization of MK-4. Patients with CKD are also known to be deficient in calcitriol. In this thesis the impact of two doses of calcitriol (20 ng/kg and 80 ng/kg), in the presence of low or high vitamin K status, on CKD-induced vascular calcification was assessed. Both calcitriol doses increased the severity of calcification regardless of vitamin K status. That is, contrary to the hypothesis, high dietary vitamin K1 was unable to attenuate the pro-calcification stimulus of calcitriol, and furthermore, warfarin treatment did not worsen it. The basis for these unanticipated findings points to the obese phenotype of the animals used potentially masking the potential benefits of calcitriol treatments, although this concept requires further study. Although several unexpected findings occurred, this thesis still fills some key gaps in knowledge pertaining to the role of vitamin K status in the development of vascular calcification during CKD and as a therapeutic intervention.
Subjects/Keywords: Chronic Kidney Disease;
Vascular Calcification
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
McCabe, K. (2015). The Role of Vitamin K in Vascular Calcification in a Rat Model of Chronic Kidney Disease
. (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/12694
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
McCabe, Kristin. “The Role of Vitamin K in Vascular Calcification in a Rat Model of Chronic Kidney Disease
.” 2015. Thesis, Queens University. Accessed February 18, 2020.
http://hdl.handle.net/1974/12694.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
McCabe, Kristin. “The Role of Vitamin K in Vascular Calcification in a Rat Model of Chronic Kidney Disease
.” 2015. Web. 18 Feb 2020.
Vancouver:
McCabe K. The Role of Vitamin K in Vascular Calcification in a Rat Model of Chronic Kidney Disease
. [Internet] [Thesis]. Queens University; 2015. [cited 2020 Feb 18].
Available from: http://hdl.handle.net/1974/12694.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
McCabe K. The Role of Vitamin K in Vascular Calcification in a Rat Model of Chronic Kidney Disease
. [Thesis]. Queens University; 2015. Available from: http://hdl.handle.net/1974/12694
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Queen Mary, University of London
21.
White, William.
Alterations in autophagy and senescence in the pathologically aged uraemic heart.
Degree: PhD, 2017, Queen Mary, University of London
URL: http://qmro.qmul.ac.uk/xmlui/handle/123456789/30887
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.766054
► There is much observational evidence to suggest that patients with chronic kidney disease are biologically 'older' than their unaffected peers. This is most obviously seen…
(more)
▼ There is much observational evidence to suggest that patients with chronic kidney disease are biologically 'older' than their unaffected peers. This is most obviously seen with cardiovascular disease: young patients on haemodialysis have a relative risk of cardiovascular mortality similar to that of people over 50 years their senior in the general population. Moreover, there are striking analogies between the effects of physiological ageing and uraemia on the structure and function of the heart and vasculature. Despite this, little work has been published looking at whether these similarities are reflected at a molecular and cellular level. Two processes implicated in ageing are autophagy and senescence. There is much inferred evidence that these processes are affected by chronic kidney disease. The aim of this work was to investigate whether autophagy and senescence are indeed altered in the uraemic heart, whether these processes might be linked, and whether the findings of these enquiries might suggest their involvement in the pathogenesis of the prematurely aged cardiac phenotype. An in vitro model of the uraemic myocardium was created using rat cardiac myoblast cells exposed to the uraemic toxin indoxyl sulphate, and in vivo models using adenine-diet and subtotal (5/6) nephrectomy rodents. Autophagy was assayed using immunoblotting, PCR array, immunohistochemistry and fluorescence microscopy, and senescence by immunoblotting and as part of an ageing-dedicated PCR array. Though not achieving statistical significance, markers of autophagy activity appeared to be increased in rat cardiac myoblast cells exposed to indoxyl sulfate, and in cardiac tissue from adenine-diet rats. Interestingly markers of autophagy activity were significantly increased in hepatic tissue from subtotal nephrectomy rats. PCR of RNA purified from cardiac tissue from adenine-diet rats demonstrated an expression of ageing-related genes analogous to that in physiological ageing. Though limited by numbers, these findings present evidence to suggest that autophagy may be upregulated as a protective mechanism in the progeroid uraemic heart, a situation possibly comparable to that in physiological ageing. Changes in cardiac autophagy and ageing in uraemia present new avenues for translational research into pathological ageing in chronic kidney disease.
Subjects/Keywords: chronic kidney disease; autophagy; senescence
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
White, W. (2017). Alterations in autophagy and senescence in the pathologically aged uraemic heart. (Doctoral Dissertation). Queen Mary, University of London. Retrieved from http://qmro.qmul.ac.uk/xmlui/handle/123456789/30887 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.766054
Chicago Manual of Style (16th Edition):
White, William. “Alterations in autophagy and senescence in the pathologically aged uraemic heart.” 2017. Doctoral Dissertation, Queen Mary, University of London. Accessed February 18, 2020.
http://qmro.qmul.ac.uk/xmlui/handle/123456789/30887 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.766054.
MLA Handbook (7th Edition):
White, William. “Alterations in autophagy and senescence in the pathologically aged uraemic heart.” 2017. Web. 18 Feb 2020.
Vancouver:
White W. Alterations in autophagy and senescence in the pathologically aged uraemic heart. [Internet] [Doctoral dissertation]. Queen Mary, University of London; 2017. [cited 2020 Feb 18].
Available from: http://qmro.qmul.ac.uk/xmlui/handle/123456789/30887 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.766054.
Council of Science Editors:
White W. Alterations in autophagy and senescence in the pathologically aged uraemic heart. [Doctoral Dissertation]. Queen Mary, University of London; 2017. Available from: http://qmro.qmul.ac.uk/xmlui/handle/123456789/30887 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.766054
Loughborough University
22.
Sood, Sanjana.
Developing RNA diagnostics for studying healthy human ageing.
Degree: PhD, 2017, Loughborough University
URL: http://hdl.handle.net/2134/24708
► Developing strategies to cope with increase in the ageing population and age-related chronic diseases is one of the societies biggest challenges. The characteristics of the…
(more)
▼ Developing strategies to cope with increase in the ageing population and age-related chronic diseases is one of the societies biggest challenges. The characteristics of the ageing process shows significant inter-individual variation. Building genomic signatures that could account for variation in health outcomes with age may facilitate early prognosis of individual age-correlated diseases (e.g. cancer, coronary artery diseases and dementia) and help in developing better targeted treatments provided years in advance of acquiring disabling symptoms for these diseases. The aim of this thesis was to explore methods for diagnosing molecular features of human ageing. In particular, we utilise multi-platform transcriptomics, independent clinical data and classification methods to evaluate which human tissues demonstrate a reproducible molecular signature for age and which clinical phenotypes correlated with these new RNA biomarkers.
Subjects/Keywords: Ageing; Chronic disease; Bioinformatics; Genetics
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Sood, S. (2017). Developing RNA diagnostics for studying healthy human ageing. (Doctoral Dissertation). Loughborough University. Retrieved from http://hdl.handle.net/2134/24708
Chicago Manual of Style (16th Edition):
Sood, Sanjana. “Developing RNA diagnostics for studying healthy human ageing.” 2017. Doctoral Dissertation, Loughborough University. Accessed February 18, 2020.
http://hdl.handle.net/2134/24708.
MLA Handbook (7th Edition):
Sood, Sanjana. “Developing RNA diagnostics for studying healthy human ageing.” 2017. Web. 18 Feb 2020.
Vancouver:
Sood S. Developing RNA diagnostics for studying healthy human ageing. [Internet] [Doctoral dissertation]. Loughborough University; 2017. [cited 2020 Feb 18].
Available from: http://hdl.handle.net/2134/24708.
Council of Science Editors:
Sood S. Developing RNA diagnostics for studying healthy human ageing. [Doctoral Dissertation]. Loughborough University; 2017. Available from: http://hdl.handle.net/2134/24708
Georgia Tech
23.
Rao, Arthi Vijayanagara.
Landscape anthropometrics: A multi-scale approach to integrating health into the regional landscape.
Degree: PhD, City and Regional Planning, 2016, Georgia Tech
URL: http://hdl.handle.net/1853/55647
► This research creates a consistent, scalable approach for incorporating health considerations into regional land planning. A prototypical framework is presented for the Atlanta region. Determinants…
(more)
▼ This research creates a consistent, scalable approach for incorporating health considerations into regional land planning. A prototypical framework is presented for the Atlanta region. Determinants of healthy places from Social/Landscape Epidemiology, Urban Planning and Landscape Ecology are incorporated into defining the landscape and its associated pattern metrics. Key research objectives are to — 1) provide a new method to measuring urban form and health relationships through the use of landscape metrics 2) analyze urban form to understand configuration, mix, spatial distribution and proportions of land uses and socioeconomic factors and their association with health outcomes. Methodologically, this research examines associations between landscape patterns at nested scales (county and tract) with mortality rates across
chronic conditions such as cancer, diabetes and heart
disease. Two primary research questions are explored— 1) Are landscape patterns significant determinants of mortality rates? 2) At what scale do landscape patterns matter for reduced mortality rates?
Landscape Pattern metrics are generated using GIS software. Random Forest, Hierarchical Clustering and other classification techniques are used to identify preliminary landscape signatures and associations. Hierarchical impacts of county and tract-level determinants on local health outcomes are examined through multilevel logistic modeling. The aim is to present a succinct set of landscape metrics to inform land use planning for healthy communities. The framework developed can be used for multiple applications including Transportation Planning and sustainable Comprehensive Planning at multiple scales.
Advisors/Committee Members: Ross, Catherine L. (advisor), Stone, Brian (committee member), Botchwey, Nisha (committee member), Amekudzi-Kennedy, Adjo (committee member), Prokopec, Gonzalo (committee member).
Subjects/Keywords: Land use; Chronic disease
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Rao, A. V. (2016). Landscape anthropometrics: A multi-scale approach to integrating health into the regional landscape. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/55647
Chicago Manual of Style (16th Edition):
Rao, Arthi Vijayanagara. “Landscape anthropometrics: A multi-scale approach to integrating health into the regional landscape.” 2016. Doctoral Dissertation, Georgia Tech. Accessed February 18, 2020.
http://hdl.handle.net/1853/55647.
MLA Handbook (7th Edition):
Rao, Arthi Vijayanagara. “Landscape anthropometrics: A multi-scale approach to integrating health into the regional landscape.” 2016. Web. 18 Feb 2020.
Vancouver:
Rao AV. Landscape anthropometrics: A multi-scale approach to integrating health into the regional landscape. [Internet] [Doctoral dissertation]. Georgia Tech; 2016. [cited 2020 Feb 18].
Available from: http://hdl.handle.net/1853/55647.
Council of Science Editors:
Rao AV. Landscape anthropometrics: A multi-scale approach to integrating health into the regional landscape. [Doctoral Dissertation]. Georgia Tech; 2016. Available from: http://hdl.handle.net/1853/55647
University of Edinburgh
24.
MacIntyre, Iain McGregor.
Modification of cardiovascular and renal risk factors using antagonists of the endothelin system.
Degree: PhD, 2014, University of Edinburgh
URL: http://hdl.handle.net/1842/10032
► Chronic kidney disease (CKD) is an important independent risk factor in the development of cardiovascular disease (CVD). Indeed, patients with CKD are far more likely…
(more)
▼ Chronic kidney disease (CKD) is an important independent risk factor in the development of cardiovascular disease (CVD). Indeed, patients with CKD are far more likely to die from CVD than reach end stage renal disease. Conventional cardiovascular risk factors and co-morbidity contribute to this increased risk of CVD. However, emerging evidence suggests other novel factors including inflammation, oxidative stress, and a shift in the balance of the vasodilator nitric oxide and vasoconstrictor endothelin system, are also important contributors. Despite increasing evidence that the endothelin system plays an important role in the development of CKD and CVD, there has been little research examining possible therapeutic benefits of its modification in patients with CKD. The overall aims of the work presented within this thesis were to examine CVD risk in patients with renal impairment and then to see what impact chronic inhibition of the endothelin system would have on risk factors for CVD and CKD progression. In the first two studies I examined markers of arterial stiffness (AS) and endothelial function in a cohort of patients with immune-mediated renal disease. I was able to show in the acute setting that improvement in renal function following treatment for these conditions leads to significant improvements in AS. Interestingly, in patients who were in remission from their renal disease, only classical cardiovascular risk factors appear to be linked to AS. In the next study I was able to prove that sitaxsentan, a selective oral ETA antagonist, did not cause functional blockade of the ETB receptor in man. This was the first study of its kind to confirm that a “selective” endothelin antagonist truly is selective in vivo: a finding that will allow more accurate mechanistic investigation of the ET system. In the final studies, I showed that in subjects with stable non-diabetic proteinuric CKD, chronic selective ETA receptor antagonism reduces blood pressure and AS, and that these systemic benefits are associated with an increase in renal blood flow and reduction in proteinuria. The reduction in proteinuria is most likely haemodynamic and linked to a fall in GFR and filtration fraction, similar to what is seen with ACE inhibitors. Importantly, these benefits were seen in patients already taking maximally tolerated renin-angiotensin aldosterone system blockade, suggesting that chronic endothelin antagonism could be an important future therapy in the management of CKD. In summary, I have shown that renal impairment can directly affect markers of arterial function and by inference increase the risk of CVD. Chronic antagonism of the endothelin system with ETA receptor blockers would appear to improve many of these biomarkers, including reductions in BP, AS and proteinuria. There were no adverse effects reported in these studies, suggesting that selective ETA antagonism may be safe enough for clinical development in CKD patients. Further larger clinical trials are warranted.
Subjects/Keywords: 616.6; endothelin; chronic kidney disease; cardiovascular disease
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
MacIntyre, I. M. (2014). Modification of cardiovascular and renal risk factors using antagonists of the endothelin system. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/10032
Chicago Manual of Style (16th Edition):
MacIntyre, Iain McGregor. “Modification of cardiovascular and renal risk factors using antagonists of the endothelin system.” 2014. Doctoral Dissertation, University of Edinburgh. Accessed February 18, 2020.
http://hdl.handle.net/1842/10032.
MLA Handbook (7th Edition):
MacIntyre, Iain McGregor. “Modification of cardiovascular and renal risk factors using antagonists of the endothelin system.” 2014. Web. 18 Feb 2020.
Vancouver:
MacIntyre IM. Modification of cardiovascular and renal risk factors using antagonists of the endothelin system. [Internet] [Doctoral dissertation]. University of Edinburgh; 2014. [cited 2020 Feb 18].
Available from: http://hdl.handle.net/1842/10032.
Council of Science Editors:
MacIntyre IM. Modification of cardiovascular and renal risk factors using antagonists of the endothelin system. [Doctoral Dissertation]. University of Edinburgh; 2014. Available from: http://hdl.handle.net/1842/10032
University of Adelaide
25.
Reilly, Rachel.
Effectiveness, cost effectiveness, acceptability and implementation barriers/facilitators of chronic kidney disease management programs for Indigenous people in Australia, New Zealand and Canada: a systematic review of mixed evidence.
Degree: 2017, University of Adelaide
URL: http://hdl.handle.net/2440/119125
► Background: Indigenous peoples in Australia, New Zealand and Canada carry a greater burden of chronic kidney disease (CKD) than the general populations in each country,…
(more)
▼ Background: Indigenous peoples in Australia, New Zealand and Canada carry a greater burden of
chronic kidney
disease (CKD) than the general populations in each country, and this burden is predicted to increase. Given the human and economic cost of dialysis, understanding how to better manage CKD at earlier stages of
disease progression is an important priority for practitioners and policy-makers. Objective: To examine the evidence relating to the effectiveness, cost-effectiveness and acceptability, as well as barriers and facilitators of implementation of
chronic kidney
disease management programs designed for Indigenous people in Australia, Canada and New Zealand. Inclusion criteria: Types of participants: Indigenous people in Australia, Canada and New Zealand diagnosed with
chronic kidney
disease. Types of intervention(s)/phenomena of interest: Health sector-led management programs explicitly designed to manage, slow progression or otherwise improve the lives of Indigenous people with
chronic kidney
disease in outpatient/community settings were considered, excluding dialysis or other forms of renal replacement therapy. Qualitative phenomena of interest were healthcare worker or patient experiences of relevant programs. Types of studies: A broad range of study-types were considered for inclusion, including quantitative studies of effectiveness, cost and cost-effectiveness, and all types of qualitative study designs. Types of outcomes: Outcomes of interest were indicators of clinical effectiveness, ability to self-manage, quality of life, cost and cost-benefit, acceptability, and barriers and enablers of implementation. Search strategy: A four-step search strategy was employed to identify relevant studies published between 2000 and 2014. Methodological quality: The studies were critically appraised using the standardized critical appraisal instruments from the Joanna Briggs Institute. Data collection and synthesis: Quantitative and qualitative data addressing the research questions were extracted using standardised tools. Due to the heterogeneity of the included studies, quantitative data on effectiveness and cost-effectiveness were summarised in narrative and tabular form. Qualitative data was synthesized using the Joanna Briggs Institute meta-aggregation approach. Results: Ten studies were included. Six studies provided evidence of clinical effectiveness relevant programs, two provided evidence of cost and cost-effectiveness, two provided qualitative evidence of barriers and facilitators of implementation of effective programs, and one provided quantitative evidence on the acceptability of a community-based
chronic kidney
disease management program. Conclusions: The quantitative, economic and qualitative evidence in this review indicates that CKD programs tailored for Indigenous people may be effective and cost-effective, and has identified a number of facilitators to the implementation of effective and acceptable CKD management programs. Given the human cost of dialysis and the growing population of people living…
Advisors/Committee Members: Gomersall, Judith (advisor), Joanna Briggs Institute (school).
Subjects/Keywords: Chronic Kidney Disease; Indigenous health; systematic review; chronic disease management
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Reilly, R. (2017). Effectiveness, cost effectiveness, acceptability and implementation barriers/facilitators of chronic kidney disease management programs for Indigenous people in Australia, New Zealand and Canada: a systematic review of mixed evidence. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/119125
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Reilly, Rachel. “Effectiveness, cost effectiveness, acceptability and implementation barriers/facilitators of chronic kidney disease management programs for Indigenous people in Australia, New Zealand and Canada: a systematic review of mixed evidence.” 2017. Thesis, University of Adelaide. Accessed February 18, 2020.
http://hdl.handle.net/2440/119125.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Reilly, Rachel. “Effectiveness, cost effectiveness, acceptability and implementation barriers/facilitators of chronic kidney disease management programs for Indigenous people in Australia, New Zealand and Canada: a systematic review of mixed evidence.” 2017. Web. 18 Feb 2020.
Vancouver:
Reilly R. Effectiveness, cost effectiveness, acceptability and implementation barriers/facilitators of chronic kidney disease management programs for Indigenous people in Australia, New Zealand and Canada: a systematic review of mixed evidence. [Internet] [Thesis]. University of Adelaide; 2017. [cited 2020 Feb 18].
Available from: http://hdl.handle.net/2440/119125.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Reilly R. Effectiveness, cost effectiveness, acceptability and implementation barriers/facilitators of chronic kidney disease management programs for Indigenous people in Australia, New Zealand and Canada: a systematic review of mixed evidence. [Thesis]. University of Adelaide; 2017. Available from: http://hdl.handle.net/2440/119125
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Brunel University
26.
Brown Connolly, Nancy.
Application of receiver operating characteristic analysis to a remote monitoring model for chronic obstructive pulmonary disease to determine utility and predictive value.
Degree: 2013, Brunel University
URL: http://bura.brunel.ac.uk/handle/2438/8057
;
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.589989
► This is a foundational study that applies Receiver Operating Characteristic (ROC) analysis to the evaluation of a chronic disease model that utilizes Remote Monitoring (RM)…
(more)
▼ This is a foundational study that applies Receiver Operating Characteristic (ROC) analysis to the evaluation of a chronic disease model that utilizes Remote Monitoring (RM) devices to identify clinical deterioration in a Chronic Obstructive Pulmonary Disease (COPD) population. Background: RM programmes in Disease Management (DM) are proliferating as one strategy to address management of chronic disease. The need to validate and quantify evidence-based value is acute. There is a need to apply new methods to better evaluate automated RM systems. ROC analysis is an engineering approach that has been widely applied to medical programmes but has not been applied to RM systems. Evaluation of classifiers, determination of thresholds and predictive accuracy for RM systems have not been evaluated using ROC analysis. Objectives: (1) apply ROC analysis to evaluation of a RM system; (2) analyse the performance of the model when applied to patient outcomes for a COPD population; (3) identify predictive classifier(s); (4) identify optimal threshold(s) and the predictive capacity of the classifiers. Methods: Parametric and non-parametric methods are utilized to determine accuracy, sensitivity, specificity and predictive capacity of classifiers Saturated Peripheral Oxygen (SpO2), Blood Pressure (BP), Pulse Rate (PR) based on event-based patient outcomes that include hospitalisation (IP), accident & emergency (A&E) and home visits (HH). Population: Patients identified with a primary diagnosis of COPD, monitored for a minimum of 183 days with at least one episode of in-patient (IP) hospitalisation for COPD in the 12 months preceding the monitoring period. Data Source: A subset of retrospective de-identified patient data from an NHS Direct evaluation of a COPD RM programme. Subsets utilized include classifiers, biometric readings, alerts generated by the system and resource utilisation. Contribution: Validates ROC methodology, identifies classifier performance and optimal threshold settings for the classifier, while making design recommendations and putting forth the next steps for research. The question answered by this research is that ROC analysis can provide additional information on the predictive capacity of RM systems. Justification of benefit: The results can be applied when evaluating health services and planning decisions on the costs and benefits. Methods can be applied to system design, protocol development, work flows and commissioning decisions based on value and benefit. Conclusion: Results validate the use of ROC analysis as a robust methodology for DM programmes that use RM devices to evaluate classifiers, thresholds and identification of the predictive capacity as well as identify areas where additional design may improve the predictive capacity of the model.
Subjects/Keywords: Receiver operating characteristic (ROC); Remote monitoring; Chronic disease monitoring; ROC analysis in chronic disease care; (COPD) chronic obstructive pulmonary disease
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Brown Connolly, N. (2013). Application of receiver operating characteristic analysis to a remote monitoring model for chronic obstructive pulmonary disease to determine utility and predictive value. (Doctoral Dissertation). Brunel University. Retrieved from http://bura.brunel.ac.uk/handle/2438/8057 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.589989
Chicago Manual of Style (16th Edition):
Brown Connolly, Nancy. “Application of receiver operating characteristic analysis to a remote monitoring model for chronic obstructive pulmonary disease to determine utility and predictive value.” 2013. Doctoral Dissertation, Brunel University. Accessed February 18, 2020.
http://bura.brunel.ac.uk/handle/2438/8057 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.589989.
MLA Handbook (7th Edition):
Brown Connolly, Nancy. “Application of receiver operating characteristic analysis to a remote monitoring model for chronic obstructive pulmonary disease to determine utility and predictive value.” 2013. Web. 18 Feb 2020.
Vancouver:
Brown Connolly N. Application of receiver operating characteristic analysis to a remote monitoring model for chronic obstructive pulmonary disease to determine utility and predictive value. [Internet] [Doctoral dissertation]. Brunel University; 2013. [cited 2020 Feb 18].
Available from: http://bura.brunel.ac.uk/handle/2438/8057 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.589989.
Council of Science Editors:
Brown Connolly N. Application of receiver operating characteristic analysis to a remote monitoring model for chronic obstructive pulmonary disease to determine utility and predictive value. [Doctoral Dissertation]. Brunel University; 2013. Available from: http://bura.brunel.ac.uk/handle/2438/8057 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.589989
Queen Mary, University of London
27.
McCafferty, Kieran.
Novel cardioprotective strategies for the uraemic heart.
Degree: Thesis (M.D.), 2011, Queen Mary, University of London
URL: http://qmro.qmul.ac.uk/xmlui/handle/123456789/8725
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.552773
► Cardiovascular disease is the leading cause of death in patients with underlying chronic kidney disease (CKD). Up to one third of patients presenting with an…
(more)
▼ Cardiovascular disease is the leading cause of death in patients with underlying chronic kidney disease (CKD). Up to one third of patients presenting with an acute coronary syndrome have CKD stage 3-5. Outcomes following acute myocardial infarction in patients with underlying CKD remain poor. CKD patients are routinely excluded from clinical trials in novel cardioprotective strategies resulting in a paucity of prospective data on which to base guidelines for clinical practice. The aims of this work were to: • Establish and characterise two models of chronic uraemia in rodents: the subtotal nephrectomy model and the adenine diet model. • Determine the effects of underlying chronic uraemia on myocardial ischaemia tolerance. • Examine pharmacological cardioprotective strategies in the context of underlying uraemia using a PARP inhibitor • Investigate the cardioprotective effects of ischaemic conditioning in the context of uraemia. Ischaemic preconditioning and postconditioning protocols were used in both uraemic and non-uraemic animals in a model of acute myocardial infarction. • Preliminary work, using standard molecular biological techniques, was carried out in order to confirm the putative survival pathways responsible for the effect of preconditioning. • Investigate the effect of combining early and late remote ischaemic preconditioning to identify whether summation of these strategies could provide additional tissue protection in a model of acute kidney injury. The results demonstrate that both models develop a uraemic phenotype. Subtotal nephrectomy animals exhibit reduced ischaemia tolerance. PARP inhibition as a pharmacological post conditioning agent was shown to be ineffective at conferring tissue protection, whereas both ischaemic preconditioning and postconditioning were effective cytoprotective strategies in both non-uraemic and uraemic animals. Furthermore, additional benefit was seen when early and late remote preconditioning were summated in a rodent model of acute kidney injury. This work provides a basis for future clinical trials in cardioprotection in the context of underlying CKD.
Subjects/Keywords: 616.635; Medicine; Cardiovascular disease; Heart disease; Chronic kidney disease
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
McCafferty, K. (2011). Novel cardioprotective strategies for the uraemic heart. (Doctoral Dissertation). Queen Mary, University of London. Retrieved from http://qmro.qmul.ac.uk/xmlui/handle/123456789/8725 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.552773
Chicago Manual of Style (16th Edition):
McCafferty, Kieran. “Novel cardioprotective strategies for the uraemic heart.” 2011. Doctoral Dissertation, Queen Mary, University of London. Accessed February 18, 2020.
http://qmro.qmul.ac.uk/xmlui/handle/123456789/8725 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.552773.
MLA Handbook (7th Edition):
McCafferty, Kieran. “Novel cardioprotective strategies for the uraemic heart.” 2011. Web. 18 Feb 2020.
Vancouver:
McCafferty K. Novel cardioprotective strategies for the uraemic heart. [Internet] [Doctoral dissertation]. Queen Mary, University of London; 2011. [cited 2020 Feb 18].
Available from: http://qmro.qmul.ac.uk/xmlui/handle/123456789/8725 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.552773.
Council of Science Editors:
McCafferty K. Novel cardioprotective strategies for the uraemic heart. [Doctoral Dissertation]. Queen Mary, University of London; 2011. Available from: http://qmro.qmul.ac.uk/xmlui/handle/123456789/8725 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.552773
Dalhousie University
28.
Haas, Evelyn.
Adolescent Perceptions Of Living With Crohn's
Disease.
Degree: Master of Nursing, School of Nursing, 2012, Dalhousie University
URL: http://hdl.handle.net/10222/15235
► In Canada, 3,300 children under the age of 20 are living with Crohn’s Disease (CD) (Crohn’s and Colitis Foundation of Canada, 2008). When an illness…
(more)
▼ In Canada, 3,300 children under the age of 20 are
living with Crohn’s
Disease (CD) (Crohn’s and Colitis Foundation of
Canada, 2008). When an illness such as CD occurs in adolescence,
the challenges associated with it are further compounded by the
developmental tasks associated with this life stage. The purpose of
this study was to understand how adolescents experience living with
CD; to explore the impact of
disease activity on their quality of
life (QOL) and the strategies utilized to maintain and improve
their QOL. Using a resiliency framework and narrative inquiry as a
research methodology, seven adolescents were interviewed. The
results include seven individual stories exemplifying their
experiences, and from the stories shared, four patterns emerged:
(1) Unconditional Support, (2) Embracing and Accepting Differences,
(3) Attitudes and Personal Beliefs and (4) Daily Coping Strategies.
These findings may have relevance for health professionals and
families and adolescents with CD.
Advisors/Committee Members: Brenda Sabo, PhD, MA, BA, RN (external-examiner), Ruth Martin-Misener, NP, PhD (graduate-coordinator), Marlene Mercer, MN, RN (thesis-reader), Angela Arra-Robar, MSN, RN (thesis-reader), Megan Aston, PhD, MEd, BScN, RN (thesis-reader), Margot Latimer, PhD, RN (thesis-supervisor), Received (ethics-approval), Not Applicable (manuscripts), No (copyright-release).
Subjects/Keywords: Adolescent; Perceptions; Crohn's Disease; Chronic
Illness
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Haas, E. (2012). Adolescent Perceptions Of Living With Crohn's
Disease. (Masters Thesis). Dalhousie University. Retrieved from http://hdl.handle.net/10222/15235
Chicago Manual of Style (16th Edition):
Haas, Evelyn. “Adolescent Perceptions Of Living With Crohn's
Disease.” 2012. Masters Thesis, Dalhousie University. Accessed February 18, 2020.
http://hdl.handle.net/10222/15235.
MLA Handbook (7th Edition):
Haas, Evelyn. “Adolescent Perceptions Of Living With Crohn's
Disease.” 2012. Web. 18 Feb 2020.
Vancouver:
Haas E. Adolescent Perceptions Of Living With Crohn's
Disease. [Internet] [Masters thesis]. Dalhousie University; 2012. [cited 2020 Feb 18].
Available from: http://hdl.handle.net/10222/15235.
Council of Science Editors:
Haas E. Adolescent Perceptions Of Living With Crohn's
Disease. [Masters Thesis]. Dalhousie University; 2012. Available from: http://hdl.handle.net/10222/15235
University of Ontario Institute of Technology
29.
Jagroop, David C.
Physical activity levels and modes of physical activity among Canadian adults with obstructive respiratory disease.
Degree: 2017, University of Ontario Institute of Technology
URL: http://hdl.handle.net/10155/839
► Purpose: To investigate physical activity levels and modes of physical activity among Canadian adults with obstructive respiratory disease. Methods: Data from respondents with self-reported asthma,…
(more)
▼ Purpose: To investigate physical activity levels and modes of physical activity among Canadian adults with obstructive respiratory
disease. Methods: Data from respondents with self-reported asthma,
chronic obstructive pulmonary
disease (COPD), and a combination of asthma and COPD (CAC) from the Canadian Community Health Survey (2013) were used for analysis. Self-reported physical activity was used to categorize respondents as active or inactive. Self-reported modes of physical activity were grouped into the following categories: walking, endurance activities, recreation activities, conventional exercise, sports, and no physical activity. Results: Adults with COPD and CAC had the lowest participation in all modes of physical activity, compared to adults without respiratory
disease. Physically active adults with CAC were less likely to report hypertension than those who were inactive. Conclusions: Physical activity levels among adults with COPD and CAC are low; while physical activity preferences in adults with asthma did not differ from the general population.
Advisors/Committee Members: Dogra, Shilpa.
Subjects/Keywords: Physical activity; Chronic disease; Health; Hypertension; Obesity
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Jagroop, D. C. (2017). Physical activity levels and modes of physical activity among Canadian adults with obstructive respiratory disease. (Thesis). University of Ontario Institute of Technology. Retrieved from http://hdl.handle.net/10155/839
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Jagroop, David C. “Physical activity levels and modes of physical activity among Canadian adults with obstructive respiratory disease.” 2017. Thesis, University of Ontario Institute of Technology. Accessed February 18, 2020.
http://hdl.handle.net/10155/839.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Jagroop, David C. “Physical activity levels and modes of physical activity among Canadian adults with obstructive respiratory disease.” 2017. Web. 18 Feb 2020.
Vancouver:
Jagroop DC. Physical activity levels and modes of physical activity among Canadian adults with obstructive respiratory disease. [Internet] [Thesis]. University of Ontario Institute of Technology; 2017. [cited 2020 Feb 18].
Available from: http://hdl.handle.net/10155/839.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Jagroop DC. Physical activity levels and modes of physical activity among Canadian adults with obstructive respiratory disease. [Thesis]. University of Ontario Institute of Technology; 2017. Available from: http://hdl.handle.net/10155/839
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Utah
30.
Johnson, Matthew Adam.
Influence of dietary fiber on c-reactive protein in dialysis patients.
Degree: MS;, Nutrition;, 2010, University of Utah
URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1247/rec/642
► Chronic kidney disease (CKD) rates continue to rise in the United States. Cardiovascular disease (CVD) accounts for half of all deaths in patients with end…
(more)
▼ Chronic kidney disease (CKD) rates continue to rise in the United States. Cardiovascular disease (CVD) accounts for half of all deaths in patients with end stage renal disease. C-reactive protein (CRP) is an indicator of inflammation and is a recognized predictor of CVD. Recent evidence supports an inverse relationship between dietary fiber and CRP in healthy populations and populations with chronic disease, but its association with inflammation in CKD has not been thoroughly explored. Dietary fiber is generally restricted in dialysis patients. It is unknown if dietary fiber could play a role in reducing CRP in CKD patients.
Subjects/Keywords: Chronic kidney disease; CRP; Dialysis; Fiber
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Johnson, M. A. (2010). Influence of dietary fiber on c-reactive protein in dialysis patients. (Masters Thesis). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1247/rec/642
Chicago Manual of Style (16th Edition):
Johnson, Matthew Adam. “Influence of dietary fiber on c-reactive protein in dialysis patients.” 2010. Masters Thesis, University of Utah. Accessed February 18, 2020.
http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1247/rec/642.
MLA Handbook (7th Edition):
Johnson, Matthew Adam. “Influence of dietary fiber on c-reactive protein in dialysis patients.” 2010. Web. 18 Feb 2020.
Vancouver:
Johnson MA. Influence of dietary fiber on c-reactive protein in dialysis patients. [Internet] [Masters thesis]. University of Utah; 2010. [cited 2020 Feb 18].
Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1247/rec/642.
Council of Science Editors:
Johnson MA. Influence of dietary fiber on c-reactive protein in dialysis patients. [Masters Thesis]. University of Utah; 2010. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1247/rec/642
◁ [1] [2] [3] [4] [5] … [60] ▶
. 
Open Access Theses and Dissertations
