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You searched for subject:(cellule pyramidale). Showing records 1 – 2 of 2 total matches.

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1. Rossi, Pierre De. Rôle du VEGF dans la régulation de la synapse glutamatergique : VEGF modulates NMDAR synaptic function and localization in the hippocampus.

Degree: Docteur es, Neurosciences, 2013, Université Claude Bernard – Lyon I

Le vascular endothelial growth factor (VEGF) un facteur de croissance essentiel du système vasculaire exerce des fonctions multiples sur les cellules nerveuses en favorisant la neurogenèse, la plasticité synaptique ou encore l'apprentissage et la mémoire. Cependant, les mécanismes impliqués dans son action régulatrice de la transmission et la plasticité synaptiques restent à élucider. Nous avons récemment mis en évidence une nouvelle interaction entre VEGFR2, le récepteur principal du VEGF, et les récepteurs NMDA (NMDAR) au cours de la migration des neurones pendant le développement du cervelet. Comme les NMDAR sont des acteurs clés de la transmission et de la plasticité synaptique, nous avons exploré le rôle du VEGF dans la régulation de l'expression et de la fonction des NMDAR synaptiques dans l'hippocampe. Nos résultats révèlent que le VEGF et son récepteur sont exprimés dans les régions CA1 et CA3 de l'hippocampe et le domaine extracellulaire de VEGFR2 peut se lier à la sous-unité GluN2B des NMDAR. Le VEGF est capable d'augmenter la transmission synaptique dépendant des NMDAR en régulant l'adressage synaptique des récepteurs exprimant la sous-unité GluN2B. Il se produit également une augmentation du nombre de synapses en présence du VEGF. Ces effets du VEGF requièrent la co-activation des récepteurs VEGFR2 et NMDAR et conduisent à un enrichissement synaptique en récepteurs glutamatergiques de type AMPA qui dépend de l'activation de la CaMKII. Nos travaux démontrent pour la première fois un rôle direct de la signalisation VEGF/VEGFR2 dans la fonction de la synapse excitatrice glutamatergique

The vascular endothelial growth factor (VEGF) plays a critical role during vascular development but recent evidence indicates that it also regulates various neuronal processes in the nervous system, such as neurogenesis, hippocampal synaptic plasticity, learning and memory. Recently, we showed a novel interaction between the glutamate receptor NMDA (NMDAR) and the VEGF receptor VEGFR2 during neuronal migration in the developing cerebellum. As NMDAR have been widely implicated in synaptic transmission and plasticity, we hypothesized that VEGF might regulate NMDAR function in hippocampal synaptic transmission and plasticity, as well as in learning and memory. Our results revealed that VEGF and its receptor VEGFR2 are expressed in the CA1 and CA3 regions of the hippocampus. Biochemical exploration highlighted an interaction between the extracellular domain of VEGFR2 and the GluN2B subunit of NMDAR. In addition, whole-cell patch clamp experiments in acute hippocampal slices showed that VEGF potentiates post-synaptic GluN2B-expressing NMDAR responses. Furthermore NMDAR and VEGFR2 co-activation in hippocampal neurons increased the pool of synaptic GluN2B-NMDAR and affects synapse number. These processes are associated with an increase in AMPAR synaptic expression and an involvment of CaMKII signaling pathway. Altogether, our results demonstrated for the first time a direct effect of VEGF on the function of excitatory…

Advisors/Committee Members: Meissirel, Claire (thesis director).

Subjects/Keywords: VEGF; NMDAR; Plasticité synaptique; Cellule pyramidale; VEGF; NMDAR; Synaptic plasticity; Pyramidal cell; 612.8

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Rossi, P. D. (2013). Rôle du VEGF dans la régulation de la synapse glutamatergique : VEGF modulates NMDAR synaptic function and localization in the hippocampus. (Doctoral Dissertation). Université Claude Bernard – Lyon I. Retrieved from http://www.theses.fr/2013LYO10279

Chicago Manual of Style (16th Edition):

Rossi, Pierre De. “Rôle du VEGF dans la régulation de la synapse glutamatergique : VEGF modulates NMDAR synaptic function and localization in the hippocampus.” 2013. Doctoral Dissertation, Université Claude Bernard – Lyon I. Accessed June 17, 2019. http://www.theses.fr/2013LYO10279.

MLA Handbook (7th Edition):

Rossi, Pierre De. “Rôle du VEGF dans la régulation de la synapse glutamatergique : VEGF modulates NMDAR synaptic function and localization in the hippocampus.” 2013. Web. 17 Jun 2019.

Vancouver:

Rossi PD. Rôle du VEGF dans la régulation de la synapse glutamatergique : VEGF modulates NMDAR synaptic function and localization in the hippocampus. [Internet] [Doctoral dissertation]. Université Claude Bernard – Lyon I; 2013. [cited 2019 Jun 17]. Available from: http://www.theses.fr/2013LYO10279.

Council of Science Editors:

Rossi PD. Rôle du VEGF dans la régulation de la synapse glutamatergique : VEGF modulates NMDAR synaptic function and localization in the hippocampus. [Doctoral Dissertation]. Université Claude Bernard – Lyon I; 2013. Available from: http://www.theses.fr/2013LYO10279


EPFL

2. Perin, Rodrigo de Campos. Emergent Dynamics in Neocortical Microcircuits.

Degree: 2010, EPFL

Interactions among neurons can take place in a wide variety of forms. It is the goal of this thesis to investigate the properties and implications of a number of these interactions that we believe are relevant for information processing in the brain. Neuroscience has progressed considerably in identifying the diverse neuronal cell-types and providing detailed information about their individual morphological, genetic and electrophysiological properties. It remains a great challenge to identify how this diversity of cells interacts at the microcircuit level. This task is made more complex by the fact that the forms of interaction are not always obvious or simple to observe, even with advanced scientific equipment. In order to achieve a better understanding and envision possible implications of the concerted activity of multiple neurons, experiments and models must often be used jointly and iteratively. In this thesis I first present the development of a computer-assisted system for multi-electrode patch-clamp that enabled new kinds of experiments, allowing qualitatively different information to be obtained concerning the interaction of multiple neurons. In the following chapters I describe the different questions addressed and approaches utilized in the investigation of neuronal interactions using multi-electrode patch-clamp experiments. The principles behind the clustered organization of synaptic connectivity in Layer V of the somatosensory cortex are the first experimental finding presented. I then quantify the ephaptic coupling between neurons and how apparently minute signals might help correlate the activity of many neurons. Next, the ubiquity of a neocortical microcircuit responsible for frequency-dependent disynaptic inhibition is demonstrated and the summation properties of this microcircuit are then analyzed. Finally a model to explain the interactions between gap junctions and synaptic transmission in the olfactory bulb is proposed. Advisors/Committee Members: Markram, Henry.

Subjects/Keywords: neocortical microcircuitry; somatosensory cortex; juvenile rat; in vitro electrophysiology; multi-electrode; patch-clamp recording; synapse; gap junction; connectivity; clustering; plasticity; ephaptic; extracellular field; excitation; frequency-dependent disynaptic inhibition; acute brain slices; pyramidal cell; Martinotti cell; microcircuit néocortical; cortex somatosensoriel; rat juvénile; électrophysiologie in-vitro; multi-électrodes; enregistrement patch-clamp; synapse; gap junction; regroupement; plasticité; ephaptique; champ extracellulaire; excitation; inhibition disynaptique fréquence-dépendante; section de cerveau; cellule pyramidale; cellule de Martinotti

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Perin, R. d. C. (2010). Emergent Dynamics in Neocortical Microcircuits. (Thesis). EPFL. Retrieved from http://infoscience.epfl.ch/record/147975

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Perin, Rodrigo de Campos. “Emergent Dynamics in Neocortical Microcircuits.” 2010. Thesis, EPFL. Accessed June 17, 2019. http://infoscience.epfl.ch/record/147975.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Perin, Rodrigo de Campos. “Emergent Dynamics in Neocortical Microcircuits.” 2010. Web. 17 Jun 2019.

Vancouver:

Perin RdC. Emergent Dynamics in Neocortical Microcircuits. [Internet] [Thesis]. EPFL; 2010. [cited 2019 Jun 17]. Available from: http://infoscience.epfl.ch/record/147975.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Perin RdC. Emergent Dynamics in Neocortical Microcircuits. [Thesis]. EPFL; 2010. Available from: http://infoscience.epfl.ch/record/147975

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.