subject:(cell cycle)

University of Manitoba

1. Baxter, Shannon A. Mechanisms of PROX1 mediated regulation of the lymphatic endothelial cell cycle.

Degree: Biochemistry and Medical Genetics, 2010, University of Manitoba

URL: http://hdl.handle.net/1993/14917

► The homeobox transcription factor PROX1 is the mammalian ortholog of the Drosophila gene Prospero. Expression of PROX1 in a subset of venous endothelial cells changes… (more)

▼ The homeobox transcription factor PROX1 is the mammalian ortholog of the Drosophila gene Prospero. Expression of PROX1 in a subset of venous endothelial cells changes their fate to lymphatic endothelial cells (LEC). PROX1 is required for lymphatic development as Prox1 null mice lack all lymphatic vasculature. PROX1 has been shown to have cell-type dependent roles in regulating the cell cycle. We hypothesize that PROX1 functions as a key cell cycle regulator in LECs and promotes their cell cycle progression. In this study, immunocytochemistry, western blotting and luciferase assays were used to characterize PROX1 mediated activation of the mouse Ccne1 promoter. Following deletion of the Prospero 1 domain (PD1∆), the resulting PROX1 protein is localized to both the nucleus and the cytoplasm. We have determined that PROX1 requires both E2F binding sites located in the Ccne1 promoter to activate transcription of the gene. We observed that siRNA knockdown of Prox1 reduced CYCLIN E1 protein levels as well as decreased cellular proliferation in LECs. In contrast, overexpression of a version of PROX1 in which the homeodomain and Prospero domain 2 (HDPD2Δ) were deleted increased CYCLIN E1 protein levels in human umbilical vein endothelial cells (HUVEC), but resulted in the arrest of cells in the G1 phase. We have also established that PROX1 is phosphorylated in primary human LECs. We have shown a role for the PD1 domain in mediating PROX1 subcellular localization and we have observed that the expression of the HDPD2Δ version of PROX1 blocks proliferation in HUVECs. We are the first to demonstrate a role for PROX1 as a transcriptional co-activator and to establish that PROX1 is phosphorylated in LECs. Advisors/Committee Members: Wigle, Jeffrey (Biochemistry and Medical Genetics) (supervisor), Eisenstat, David (Biochemistry and Medical Genetics) Gibson, Spencer (Biochemistry and Medical Genetics) Mowat, Micheal (Biochemistry and Medical Genetics) Dixon, Ian (Physiology) (examiningcommittee).

Subjects/Keywords: Lymphatic endothelial cell; Cell cycle

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APA (6^th Edition):

Baxter, S. A. (2010). Mechanisms of PROX1 mediated regulation of the lymphatic endothelial cell cycle. (Masters Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/14917

Chicago Manual of Style (16^th Edition):

Baxter, Shannon A. “Mechanisms of PROX1 mediated regulation of the lymphatic endothelial cell cycle.” 2010. Masters Thesis, University of Manitoba. Accessed January 23, 2021. http://hdl.handle.net/1993/14917.

MLA Handbook (7^th Edition):

Baxter, Shannon A. “Mechanisms of PROX1 mediated regulation of the lymphatic endothelial cell cycle.” 2010. Web. 23 Jan 2021.

Vancouver:

Baxter SA. Mechanisms of PROX1 mediated regulation of the lymphatic endothelial cell cycle. [Internet] [Masters thesis]. University of Manitoba; 2010. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/1993/14917.

Council of Science Editors:

Baxter SA. Mechanisms of PROX1 mediated regulation of the lymphatic endothelial cell cycle. [Masters Thesis]. University of Manitoba; 2010. Available from: http://hdl.handle.net/1993/14917

Hong Kong University of Science and Technology

2. Tang, Rui LIFS. Anti-apoptotic functions of BCL-W, MCL-1, and A1 in mitotic cell death.

Degree: 2016, Hong Kong University of Science and Technology

URL: http://repository.ust.hk/ir/Record/1783.1-100402 ; https://doi.org/10.14711/thesis-b1626285 ; http://repository.ust.hk/ir/bitstream/1783.1-100402/1/th_redirect.html

► Anti-microtubule agents activate the spindle-assembly checkpoint by perturbing spindle formation and trapping cells in mitosis. Whether cells undergo mitotic cell death subsequently is an important… (more)

Subjects/Keywords: Cell cycle ; Mitosis ; Cell death

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APA (6^th Edition):

Tang, R. L. (2016). Anti-apoptotic functions of BCL-W, MCL-1, and A1 in mitotic cell death. (Thesis). Hong Kong University of Science and Technology. Retrieved from http://repository.ust.hk/ir/Record/1783.1-100402 ; https://doi.org/10.14711/thesis-b1626285 ; http://repository.ust.hk/ir/bitstream/1783.1-100402/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tang, Rui LIFS. “Anti-apoptotic functions of BCL-W, MCL-1, and A1 in mitotic cell death.” 2016. Thesis, Hong Kong University of Science and Technology. Accessed January 23, 2021. http://repository.ust.hk/ir/Record/1783.1-100402 ; https://doi.org/10.14711/thesis-b1626285 ; http://repository.ust.hk/ir/bitstream/1783.1-100402/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tang, Rui LIFS. “Anti-apoptotic functions of BCL-W, MCL-1, and A1 in mitotic cell death.” 2016. Web. 23 Jan 2021.

Vancouver:

Tang RL. Anti-apoptotic functions of BCL-W, MCL-1, and A1 in mitotic cell death. [Internet] [Thesis]. Hong Kong University of Science and Technology; 2016. [cited 2021 Jan 23]. Available from: http://repository.ust.hk/ir/Record/1783.1-100402 ; https://doi.org/10.14711/thesis-b1626285 ; http://repository.ust.hk/ir/bitstream/1783.1-100402/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tang RL. Anti-apoptotic functions of BCL-W, MCL-1, and A1 in mitotic cell death. [Thesis]. Hong Kong University of Science and Technology; 2016. Available from: http://repository.ust.hk/ir/Record/1783.1-100402 ; https://doi.org/10.14711/thesis-b1626285 ; http://repository.ust.hk/ir/bitstream/1783.1-100402/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

3. Takatsuka, Hirotomo. Studies on functional roles of CDK-activating kinases in Arabidopsis development : シロイヌナズナの発生におけるCDK活性化キナーゼの機能に関する研究; シロイヌナズナノハッセイニオケル CDK カッセイカキナーゼノキノウニカンスルケンキュウ.

Degree: Nara Institute of Science and Technology / 奈良先端科学技術大学院大学

URL: http://hdl.handle.net/10061/5706

Subjects/Keywords: cell cycle

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APA (6^th Edition):

Takatsuka, H. (n.d.). Studies on functional roles of CDK-activating kinases in Arabidopsis development : シロイヌナズナの発生におけるCDK活性化キナーゼの機能に関する研究; シロイヌナズナノハッセイニオケル CDK カッセイカキナーゼノキノウニカンスルケンキュウ. (Thesis). Nara Institute of Science and Technology / 奈良先端科学技術大学院大学. Retrieved from http://hdl.handle.net/10061/5706

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Takatsuka, Hirotomo. “Studies on functional roles of CDK-activating kinases in Arabidopsis development : シロイヌナズナの発生におけるCDK活性化キナーゼの機能に関する研究; シロイヌナズナノハッセイニオケル CDK カッセイカキナーゼノキノウニカンスルケンキュウ.” Thesis, Nara Institute of Science and Technology / 奈良先端科学技術大学院大学. Accessed January 23, 2021. http://hdl.handle.net/10061/5706.

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Takatsuka, Hirotomo. “Studies on functional roles of CDK-activating kinases in Arabidopsis development : シロイヌナズナの発生におけるCDK活性化キナーゼの機能に関する研究; シロイヌナズナノハッセイニオケル CDK カッセイカキナーゼノキノウニカンスルケンキュウ.” Web. 23 Jan 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Takatsuka H. Studies on functional roles of CDK-activating kinases in Arabidopsis development : シロイヌナズナの発生におけるCDK活性化キナーゼの機能に関する研究; シロイヌナズナノハッセイニオケル CDK カッセイカキナーゼノキノウニカンスルケンキュウ. [Internet] [Thesis]. Nara Institute of Science and Technology / 奈良先端科学技術大学院大学; [cited 2021 Jan 23]. Available from: http://hdl.handle.net/10061/5706.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

Takatsuka H. Studies on functional roles of CDK-activating kinases in Arabidopsis development : シロイヌナズナの発生におけるCDK活性化キナーゼの機能に関する研究; シロイヌナズナノハッセイニオケル CDK カッセイカキナーゼノキノウニカンスルケンキュウ. [Thesis]. Nara Institute of Science and Technology / 奈良先端科学技術大学院大学; Available from: http://hdl.handle.net/10061/5706

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Vanderbilt University

4. Talley, Jennell Marie. Exploring the assembly and function of the telomerase accessory proteins Est1 and Est3 in Saccharomyces cerevisiae.

Degree: PhD, Biological Sciences, 2011, Vanderbilt University

URL: http://hdl.handle.net/1803/13166

► The work presented in this dissertation focuses on a how the telomerase complex assembles both in vivo and in vitro and begins to explore how… (more)

Subjects/Keywords: proteasome; TERT; cell cycle; Telomere

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APA (6^th Edition):

Talley, J. M. (2011). Exploring the assembly and function of the telomerase accessory proteins Est1 and Est3 in Saccharomyces cerevisiae. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/13166

Chicago Manual of Style (16^th Edition):

Talley, Jennell Marie. “Exploring the assembly and function of the telomerase accessory proteins Est1 and Est3 in Saccharomyces cerevisiae.” 2011. Doctoral Dissertation, Vanderbilt University. Accessed January 23, 2021. http://hdl.handle.net/1803/13166.

MLA Handbook (7^th Edition):

Talley, Jennell Marie. “Exploring the assembly and function of the telomerase accessory proteins Est1 and Est3 in Saccharomyces cerevisiae.” 2011. Web. 23 Jan 2021.

Vancouver:

Talley JM. Exploring the assembly and function of the telomerase accessory proteins Est1 and Est3 in Saccharomyces cerevisiae. [Internet] [Doctoral dissertation]. Vanderbilt University; 2011. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/1803/13166.

Council of Science Editors:

Talley JM. Exploring the assembly and function of the telomerase accessory proteins Est1 and Est3 in Saccharomyces cerevisiae. [Doctoral Dissertation]. Vanderbilt University; 2011. Available from: http://hdl.handle.net/1803/13166

University of Texas Southwestern Medical Center

5. Chaudhary, Jaideep. Function And Recruitment Of Centromeric Heterochromatin Protein 1.

Degree: 2011, University of Texas Southwestern Medical Center

URL: http://hdl.handle.net/2152.5/846

► During early mitosis, the sister chromatids are held together by Cohesin, a protein complex composed of Smc3, Smc1, Scc1/Rad21 and Scc3. Cohesin is first released… (more)

Subjects/Keywords: Cell Cycle Proteins; Mitosis; Heterochromatin

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APA (6^th Edition):

Chaudhary, J. (2011). Function And Recruitment Of Centromeric Heterochromatin Protein 1. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/846

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chaudhary, Jaideep. “Function And Recruitment Of Centromeric Heterochromatin Protein 1.” 2011. Thesis, University of Texas Southwestern Medical Center. Accessed January 23, 2021. http://hdl.handle.net/2152.5/846.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chaudhary, Jaideep. “Function And Recruitment Of Centromeric Heterochromatin Protein 1.” 2011. Web. 23 Jan 2021.

Vancouver:

Chaudhary J. Function And Recruitment Of Centromeric Heterochromatin Protein 1. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2011. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/2152.5/846.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chaudhary J. Function And Recruitment Of Centromeric Heterochromatin Protein 1. [Thesis]. University of Texas Southwestern Medical Center; 2011. Available from: http://hdl.handle.net/2152.5/846

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Texas Southwestern Medical Center

6. Cai, Ling. Insights into the Metabolic Regulation of Growth and Proliferation in Saccharomyces Cerevisiae.

Degree: 2013, University of Texas Southwestern Medical Center

URL: http://hdl.handle.net/2152.5/2715

► Cells needs to gauge their capacity to grow based on nutrient availability, and adopt different metabolic strategies for optimal growth and survival. We have investigated… (more)

▼ Cells needs to gauge their capacity to grow based on nutrient availability, and adopt different metabolic strategies for optimal growth and survival. We have investigated the molecular mechanism of how growth decisions are made based on metabolic status and how metabolic enzymes are regulated by nutrient availability. In the first part of this study, we report that acetyl-CoA is the downstream metabolite of carbon sources that represents a critical metabolic signal for growth and proliferation. Upon entry into growth, intracellular acetyl-CoA levels increase substantially and consequently induce the Gcn5p/SAGA-catalyzed acetylation of histones at genes important vi for growth, thereby enabling their rapid transcription and commitment to growth. Acetyl-CoA functions as a carbon-source rheostat that signals the initiation of the cellular growth program by promoting the acetylation of histones specifically at growth genes. In the second part of the study, we report the dynamic modification of ribosome biogenesis transcription factor Ifh1p regulated by different metabolic cues. Ribosome biogenesis requires an enormous commitment of energy and resources in growing cells. We show that Ifh1p is dynamically acetylated and phosphorylated as a function of the growth state of cells. Ifh1p is acetylated at numerous sites in its N-terminal region by Gcn5p and deacetylated by NAD+-dependent deacetylases of the sirtuin family. Acetylation of Ifh1p is responsive to intracellular acetyl-CoA levels and serves to regulate the stability of Ifh1p. The phosphorylation of Ifh1p is mediated by Protein Kinase A and is dependent on TORC1 signaling. Instead of modulating overall rates of RP gene transcription or growth, these nutrient-responsive modifications of Ifh1p play a more prominent role in the regulation of cellular replicative lifespan. Finally, we report the different roles of acetyl-CoA synthetases Acs1p and Acs2p in yeast metabolism. While Acs2p is important for rapid growth in glucose medium, Acs1p has unique roles in more challenging growth conditions. It is important for yeast metabolic cycling and is recruited to foci structure near mitochondria that might be involved in shuttling acetyl-CoA into the mitochondria during hypoxia. Advisors/Committee Members: Liu, Yi, DeBerardinis, Ralph J., Li, Bing, Ross, Elliott M..

Subjects/Keywords: Saccharomyces cerevisiae; Cell Cycle; Mitosis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cai, L. (2013). Insights into the Metabolic Regulation of Growth and Proliferation in Saccharomyces Cerevisiae. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/2715

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Cai, Ling. “Insights into the Metabolic Regulation of Growth and Proliferation in Saccharomyces Cerevisiae.” 2013. Thesis, University of Texas Southwestern Medical Center. Accessed January 23, 2021. http://hdl.handle.net/2152.5/2715.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Cai, Ling. “Insights into the Metabolic Regulation of Growth and Proliferation in Saccharomyces Cerevisiae.” 2013. Web. 23 Jan 2021.

Vancouver:

Cai L. Insights into the Metabolic Regulation of Growth and Proliferation in Saccharomyces Cerevisiae. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2013. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/2152.5/2715.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cai L. Insights into the Metabolic Regulation of Growth and Proliferation in Saccharomyces Cerevisiae. [Thesis]. University of Texas Southwestern Medical Center; 2013. Available from: http://hdl.handle.net/2152.5/2715

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Oregon State University

7. Worthington, David H. Hydroxyurea : physiological effects on Tetrahymena pyriformis and use in cell cycle analysis.

Degree: PhD, Genetics, 1973, Oregon State University

URL: http://hdl.handle.net/1957/44777

► Hydroxyurea (10mM) blocks the exponential growth of Tetrahymena pyriformis (GL-I) populations by arresting progress through the cell cycle once the cells enter S-phase. Autoradiographic analysis… (more)

▼ Hydroxyurea (10mM) blocks the exponential growth of Tetrahymena pyriformis (GL-I) populations by arresting progress through the cell cycle once the cells enter S-phase. Autoradiographic analysis reveals that HU reduces the uptake of tritiated thymidine (³H-TdR) into macronuclear DNA in S-phase cells to about 1/5 of that in untreated S-phase cells. These slowly synthesizing cells do not divide (even after 10 days) until the HU is removed. The HU-blocked cells are also rescued from S-phase arrest by adding 0. 5mM each of all four DNAprecursor deoxyribonucleosides (XdRs) thus indicating the primary effect of HU is the inhibition of the reduction of ribonucleosides. When the HU-block is removed by either washing the HU from the medium or by rescue with XdRs an excessive delay in recovering the capacity to divide is specifically induced in cells which were in S-phase at time of addition of HU. This delay may be due to the time needed to repair damage to the DNA which was induced specifically during S-phase. Fluoromicroscopic examination of euchrysine-stained cells exposed for a minimum of two hours starting in S-phase show a radical morphological change in the macronucleus. This phenomenon, termed the "halo effect," is characterized by the formation of apparently membrane-associated chromatin aggregates surrounding a constricted chromatin mass. Halo-induction by HU is S-phase specific and upon removal of the HU-block the halo remains until the first recovery division. The halo effect is interpreted as being a morphological indication of the cell's repair response to the damaging effects of HU upon macronuclear DNA. Observations of division of individual cells in microdrops, plus autoradiographic studies using ³H-TdR and standard cell cycle analysis techniques, reveal that HU blocks all cells in the initial 92% of S-phase but does not affect cells in the remaining 8 % of S-phase or in G₂ and division. Thus the fraction of the population of cells that is in G₂ can be approximately determined (within 6 minutes) by the fraction of the population able to divide in the presence of HU. This fraction can be related to the approximate duration of G₂ after mathematically compensating for the age gradient. Thus G₂ analysis of T. pyriformis (GL-I) is accomplished easily, quickly, and inexpensively with the use of HU. The possibilities of utilizing Sphase specific recovery delay and halo induction for simple means of determining the durations of G₁ and S-phase respectively are also discussed. The addition of all four XdRs (0. 5mM) to exponentially growing cells in rich organic complete medium without HU results in the generation time of these cells being decreased by 20%. Cell cycle analysis with phosphorus-33 (³³P) and experiments involving cell phase sensitivity to the presence of excess XdRs show that the excess XdRs are taken up and incorporated or pooled entirely during the initial 50% of S-phase. This acceleration of early S-phase completely accounts for the abbreviated generation… Advisors/Committee Members: Nachtwey, D. S. (advisor).

Subjects/Keywords: Cell cycle

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APA (6^th Edition):

Worthington, D. H. (1973). Hydroxyurea : physiological effects on Tetrahymena pyriformis and use in cell cycle analysis. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/44777

Chicago Manual of Style (16^th Edition):

Worthington, David H. “Hydroxyurea : physiological effects on Tetrahymena pyriformis and use in cell cycle analysis.” 1973. Doctoral Dissertation, Oregon State University. Accessed January 23, 2021. http://hdl.handle.net/1957/44777.

MLA Handbook (7^th Edition):

Worthington, David H. “Hydroxyurea : physiological effects on Tetrahymena pyriformis and use in cell cycle analysis.” 1973. Web. 23 Jan 2021.

Vancouver:

Worthington DH. Hydroxyurea : physiological effects on Tetrahymena pyriformis and use in cell cycle analysis. [Internet] [Doctoral dissertation]. Oregon State University; 1973. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/1957/44777.

Council of Science Editors:

Worthington DH. Hydroxyurea : physiological effects on Tetrahymena pyriformis and use in cell cycle analysis. [Doctoral Dissertation]. Oregon State University; 1973. Available from: http://hdl.handle.net/1957/44777

Harvard University

8. Ho, Po-Yi. Models of microbial cell cycles.

Degree: PhD, 2019, Harvard University

URL: http://nrs.harvard.edu/urn-3:HUL.InstRepos:42029521

►

Cell division is a fundamental process of life, yet how the timing of cell division is regulated in microorganisms remain unclear. In this dissertation, I… (more)

Subjects/Keywords: Models; microbial cell cycle

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ho, P. (2019). Models of microbial cell cycles. (Doctoral Dissertation). Harvard University. Retrieved from http://nrs.harvard.edu/urn-3:HUL.InstRepos:42029521

Chicago Manual of Style (16^th Edition):

Ho, Po-Yi. “Models of microbial cell cycles.” 2019. Doctoral Dissertation, Harvard University. Accessed January 23, 2021. http://nrs.harvard.edu/urn-3:HUL.InstRepos:42029521.

MLA Handbook (7^th Edition):

Ho, Po-Yi. “Models of microbial cell cycles.” 2019. Web. 23 Jan 2021.

Vancouver:

Ho P. Models of microbial cell cycles. [Internet] [Doctoral dissertation]. Harvard University; 2019. [cited 2021 Jan 23]. Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:42029521.

Council of Science Editors:

Ho P. Models of microbial cell cycles. [Doctoral Dissertation]. Harvard University; 2019. Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:42029521

Hong Kong University of Science and Technology

9. Zhao, Yichen LIFS. Functional study of GAS2L1 in mitosis.

Degree: 2015, Hong Kong University of Science and Technology

URL: http://repository.ust.hk/ir/Record/1783.1-92284 ; https://doi.org/10.14711/thesis-b1514805 ; http://repository.ust.hk/ir/bitstream/1783.1-92284/1/th_redirect.html

► Mitosis, as a very important process during the cell cycle, decides chromosome duplication, organelle separation and cell division. During mitosis, metaphase is middle of whole… (more)

Subjects/Keywords: Mitosis ; Cell cycle ; Carrier proteins

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APA (6^th Edition):

Zhao, Y. L. (2015). Functional study of GAS2L1 in mitosis. (Thesis). Hong Kong University of Science and Technology. Retrieved from http://repository.ust.hk/ir/Record/1783.1-92284 ; https://doi.org/10.14711/thesis-b1514805 ; http://repository.ust.hk/ir/bitstream/1783.1-92284/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Zhao, Yichen LIFS. “Functional study of GAS2L1 in mitosis.” 2015. Thesis, Hong Kong University of Science and Technology. Accessed January 23, 2021. http://repository.ust.hk/ir/Record/1783.1-92284 ; https://doi.org/10.14711/thesis-b1514805 ; http://repository.ust.hk/ir/bitstream/1783.1-92284/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Zhao, Yichen LIFS. “Functional study of GAS2L1 in mitosis.” 2015. Web. 23 Jan 2021.

Vancouver:

Zhao YL. Functional study of GAS2L1 in mitosis. [Internet] [Thesis]. Hong Kong University of Science and Technology; 2015. [cited 2021 Jan 23]. Available from: http://repository.ust.hk/ir/Record/1783.1-92284 ; https://doi.org/10.14711/thesis-b1514805 ; http://repository.ust.hk/ir/bitstream/1783.1-92284/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Zhao YL. Functional study of GAS2L1 in mitosis. [Thesis]. Hong Kong University of Science and Technology; 2015. Available from: http://repository.ust.hk/ir/Record/1783.1-92284 ; https://doi.org/10.14711/thesis-b1514805 ; http://repository.ust.hk/ir/bitstream/1783.1-92284/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Hong Kong University of Science and Technology

10. Qin, Yan LIFS. The role of hNOC3 in human DNA replication.

Degree: 2013, Hong Kong University of Science and Technology

URL: http://repository.ust.hk/ir/Record/1783.1-94452 ; https://doi.org/10.14711/thesis-b1266302 ; http://repository.ust.hk/ir/bitstream/1783.1-94452/1/th_redirect.html

► Noc3p (nucleolar complex-associated protein) is highly conserved in eukaryotes, and it plays a critical role in the initiation of DNA replication in budding yeast. Noc3p… (more)

Subjects/Keywords: DNA replication ; Cell cycle

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APA (6^th Edition):

Qin, Y. L. (2013). The role of hNOC3 in human DNA replication. (Thesis). Hong Kong University of Science and Technology. Retrieved from http://repository.ust.hk/ir/Record/1783.1-94452 ; https://doi.org/10.14711/thesis-b1266302 ; http://repository.ust.hk/ir/bitstream/1783.1-94452/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Qin, Yan LIFS. “The role of hNOC3 in human DNA replication.” 2013. Thesis, Hong Kong University of Science and Technology. Accessed January 23, 2021. http://repository.ust.hk/ir/Record/1783.1-94452 ; https://doi.org/10.14711/thesis-b1266302 ; http://repository.ust.hk/ir/bitstream/1783.1-94452/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Qin, Yan LIFS. “The role of hNOC3 in human DNA replication.” 2013. Web. 23 Jan 2021.

Vancouver:

Qin YL. The role of hNOC3 in human DNA replication. [Internet] [Thesis]. Hong Kong University of Science and Technology; 2013. [cited 2021 Jan 23]. Available from: http://repository.ust.hk/ir/Record/1783.1-94452 ; https://doi.org/10.14711/thesis-b1266302 ; http://repository.ust.hk/ir/bitstream/1783.1-94452/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Qin YL. The role of hNOC3 in human DNA replication. [Thesis]. Hong Kong University of Science and Technology; 2013. Available from: http://repository.ust.hk/ir/Record/1783.1-94452 ; https://doi.org/10.14711/thesis-b1266302 ; http://repository.ust.hk/ir/bitstream/1783.1-94452/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Hong Kong University of Science and Technology

11. Xu, Kaichun LIFS. Molecular regulation of mitotic slippage.

Degree: 2016, Hong Kong University of Science and Technology

URL: http://repository.ust.hk/ir/Record/1783.1-99847 ; https://doi.org/10.14711/thesis-b1626381 ; http://repository.ust.hk/ir/bitstream/1783.1-99847/1/th_redirect.html

► Antimicrotubule drugs are effective chemotherapeutic agents because they can disrupt normal mitotic spindle and activate the spindle-assembly checkpoint (SAC) to arrest cells in mitosis, thereby… (more)

Subjects/Keywords: Cell cycle ; Regulation ; Mitosis

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APA (6^th Edition):

Xu, K. L. (2016). Molecular regulation of mitotic slippage. (Thesis). Hong Kong University of Science and Technology. Retrieved from http://repository.ust.hk/ir/Record/1783.1-99847 ; https://doi.org/10.14711/thesis-b1626381 ; http://repository.ust.hk/ir/bitstream/1783.1-99847/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Xu, Kaichun LIFS. “Molecular regulation of mitotic slippage.” 2016. Thesis, Hong Kong University of Science and Technology. Accessed January 23, 2021. http://repository.ust.hk/ir/Record/1783.1-99847 ; https://doi.org/10.14711/thesis-b1626381 ; http://repository.ust.hk/ir/bitstream/1783.1-99847/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Xu, Kaichun LIFS. “Molecular regulation of mitotic slippage.” 2016. Web. 23 Jan 2021.

Vancouver:

Xu KL. Molecular regulation of mitotic slippage. [Internet] [Thesis]. Hong Kong University of Science and Technology; 2016. [cited 2021 Jan 23]. Available from: http://repository.ust.hk/ir/Record/1783.1-99847 ; https://doi.org/10.14711/thesis-b1626381 ; http://repository.ust.hk/ir/bitstream/1783.1-99847/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Xu KL. Molecular regulation of mitotic slippage. [Thesis]. Hong Kong University of Science and Technology; 2016. Available from: http://repository.ust.hk/ir/Record/1783.1-99847 ; https://doi.org/10.14711/thesis-b1626381 ; http://repository.ust.hk/ir/bitstream/1783.1-99847/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Louisville

12. Stallons, Lindsey Jay, 1983-. DNA polymerase iota promotes G2/M checkpoint activation and genetic stability after UV-induced DNA damage.

Degree: PhD, 2011, University of Louisville

URL: 10.18297/etd/1369 ; https://ir.library.louisville.edu/etd/1369

► Unrepaired DNA damage poses a serious threat to the genetic stability of a replicating cell. One mechanism of tolerating this damage is translesion DNA synthesis… (more)

▼ Unrepaired DNA damage poses a serious threat to the genetic stability of a replicating cell. One mechanism of tolerating this damage is translesion DNA synthesis (TLS), in which an accessory polymerase synthesizes DNA directly across from a damaged template. TLS is carried out by polymerase ? (Pol ?), 1, K, and REV1 in the Y-family and Pol ? in the B-family. Pol ? has the well-characterized ability to perform accurate bypass of the most common UV-induced DNA lesion; loss of Pol ? results in hypermutability and severely increased risk of skin cancer. The high mutation frequency in Pol ?-deficient cells has been attributed to the mutagenic TLS activity of Pol ?. Deletion of Pol ? in the Pol ?-deficient background results in greatly reduced UV-induced mutation frequencies, but unexpectedly the double knockout mice develop cancer faster than mice deficient in Pol ? alone. This unexpected finding suggests that Pol may have a cellular role outside of TLS, which we investigated using a gene expression approach. Pol ? -proficient and -deficient cells showed markedly different mRNA and microRNA expression changes after UV treatment. Bioinformatics analysis revealed that the G2/M checkpoint was the main point of divergence in the transcriptional response. Western blotting showed that G2/M markers were increased and G1/S markers were decreased 24 hours after UV treatment in Pol ?-proficient cells, indicating an active checkpoint. Loss of Pol ? reversed these trends. FACS analysis of cell cycle kinetics showed a time-dependent increase in the number of aneuploid Pol ?-deficient cells after UV treatment; this degree of genetic instability was not seen in Pol ?-proficient cells. We also examined the effects of Pol ? on UV carcinogenesis in isogenic mice lacking Xpa, a gene central to the repair of UV-induced DNA damage. Loss of Pol ? caused a trend towards reduced tumor latency (p=0.057), while Pol ?-deficiency caused a highly significant reduction in tumor latency (p < 0.01). These results indicate that Pol ? plays a role in G2/M checkpoint regulation and suppressing UV carcinogenesis. At the cost of frequent point mutations, Pol ? could help cells avoid death by resolving stalled replication forks and preventing double strand breaks. Advisors/Committee Members: States, J. Christopher.

Subjects/Keywords: Mutagenesis; Cell cycle; Polymerase iota

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APA (6^th Edition):

Stallons, Lindsey Jay, 1. (2011). DNA polymerase iota promotes G2/M checkpoint activation and genetic stability after UV-induced DNA damage. (Doctoral Dissertation). University of Louisville. Retrieved from 10.18297/etd/1369 ; https://ir.library.louisville.edu/etd/1369

Chicago Manual of Style (16^th Edition):

Stallons, Lindsey Jay, 1983-. “DNA polymerase iota promotes G2/M checkpoint activation and genetic stability after UV-induced DNA damage.” 2011. Doctoral Dissertation, University of Louisville. Accessed January 23, 2021. 10.18297/etd/1369 ; https://ir.library.louisville.edu/etd/1369.

MLA Handbook (7^th Edition):

Stallons, Lindsey Jay, 1983-. “DNA polymerase iota promotes G2/M checkpoint activation and genetic stability after UV-induced DNA damage.” 2011. Web. 23 Jan 2021.

Vancouver:

Stallons, Lindsey Jay 1. DNA polymerase iota promotes G2/M checkpoint activation and genetic stability after UV-induced DNA damage. [Internet] [Doctoral dissertation]. University of Louisville; 2011. [cited 2021 Jan 23]. Available from: 10.18297/etd/1369 ; https://ir.library.louisville.edu/etd/1369.

Council of Science Editors:

Stallons, Lindsey Jay 1. DNA polymerase iota promotes G2/M checkpoint activation and genetic stability after UV-induced DNA damage. [Doctoral Dissertation]. University of Louisville; 2011. Available from: 10.18297/etd/1369 ; https://ir.library.louisville.edu/etd/1369

University of Sydney

13. Dokumcu, Kagan Ali. Non-encoded Mechanisms of Stress Adaptation in Cancer .

Degree: 2019, University of Sydney

URL: http://hdl.handle.net/2123/20959

► Tumour resistance attributed to clonal evolution of neoplastic cells, poses a major challenge for treatment of cancer. Clonality of neoplastic cells is mainly considered to… (more)

Subjects/Keywords: Cancer; Autophagy; Cell Cycle; MicroRNA

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APA (6^th Edition):

Dokumcu, K. A. (2019). Non-encoded Mechanisms of Stress Adaptation in Cancer . (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/20959

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Dokumcu, Kagan Ali. “Non-encoded Mechanisms of Stress Adaptation in Cancer .” 2019. Thesis, University of Sydney. Accessed January 23, 2021. http://hdl.handle.net/2123/20959.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Dokumcu, Kagan Ali. “Non-encoded Mechanisms of Stress Adaptation in Cancer .” 2019. Web. 23 Jan 2021.

Vancouver:

Dokumcu KA. Non-encoded Mechanisms of Stress Adaptation in Cancer . [Internet] [Thesis]. University of Sydney; 2019. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/2123/20959.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Dokumcu KA. Non-encoded Mechanisms of Stress Adaptation in Cancer . [Thesis]. University of Sydney; 2019. Available from: http://hdl.handle.net/2123/20959

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Notre Dame

14. Randy Jeffrey. Effects of the Anti-Androgen Bicalutamide on Prostate Cancer Cells</h1>.

Degree: Biological Sciences, 2012, University of Notre Dame

URL: https://curate.nd.edu/show/qf85n873c5q

► The use of anti-androgen therapy for the treatment of invasive and metastatic prostate cancer is common practice. However, after an initial response, the tumor… (more)

Subjects/Keywords: cell death; prostate cancer; cell cycle; bicalutamide

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APA (6^th Edition):

Jeffrey, R. (2012). Effects of the Anti-Androgen Bicalutamide on Prostate Cancer Cells</h1>. (Thesis). University of Notre Dame. Retrieved from https://curate.nd.edu/show/qf85n873c5q

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jeffrey, Randy. “Effects of the Anti-Androgen Bicalutamide on Prostate Cancer Cells</h1>.” 2012. Thesis, University of Notre Dame. Accessed January 23, 2021. https://curate.nd.edu/show/qf85n873c5q.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jeffrey, Randy. “Effects of the Anti-Androgen Bicalutamide on Prostate Cancer Cells</h1>.” 2012. Web. 23 Jan 2021.

Vancouver:

Jeffrey R. Effects of the Anti-Androgen Bicalutamide on Prostate Cancer Cells</h1>. [Internet] [Thesis]. University of Notre Dame; 2012. [cited 2021 Jan 23]. Available from: https://curate.nd.edu/show/qf85n873c5q.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jeffrey R. Effects of the Anti-Androgen Bicalutamide on Prostate Cancer Cells</h1>. [Thesis]. University of Notre Dame; 2012. Available from: https://curate.nd.edu/show/qf85n873c5q

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Washington University in St. Louis

15. Arjes, Heidi Ann. Failsafe Mechanisms Coordinate Cell Division and the Initiation of DNA Replication in Bacteria.

Degree: PhD, Biology and Biomedical Sciences: Molecular Genetics and Genomics, 2014, Washington University in St. Louis

URL: https://openscholarship.wustl.edu/etd/1280

► During the cell cycle, a cell must replicate its DNA, segregate the genome and divide into two identical daughter cells with full chromosomes. This… (more)

▼ During the cell cycle, a cell must replicate its DNA, segregate the genome and divide into two identical daughter cells with full chromosomes. This process needs to be specifically coordinated to ensure that cell division does not occur before DNA replication has finished and that the cell septates precisely at midcell to segregate one chromosome to each daughter cell. If cells divide before the chromosome is fully replicated, the chromosome could be guillotined or cell division could occur resulting in cells without chromosomes. If division does not occur properly, the cells elongate but do not divide and form multinucleate filaments. In wild-type cells, DNA replication and cell division appear to be perfectly coordinated. Even at faster doubling times, the cell cycle is synchronized so that DNA replication initiates and terminates once per cell division, the cell division protein FtsZ assembles into a ring precisely at midcell, and cell septation only occurs once the chromosome has replicated and segregated. Despite this apparent coordination, the long-held view in the field is that cell division and DNA replication are independent cycles that are merely coordinated during normal growth. However, it remains widely accepted that cell division is independent from DNA replication in bacteria. In this dissertation, I make 3 contributions to the field of cell cycle regulation. First, I identify a control point that couples cell division with the initiation of DNA replication. Second, I show that long-term inhibitions of cell division lead to terminal cell cycle arrest at a time we have termed the "Point of no return" or PONR. The PONR is equivalent to the eukaryotic G<sub>0<sub> arrest and validates the development of antibiotics that target the cell division machinery. Third, I characterized determinants for assembly of the tubulin-like protein FtsZ using a genetic approach. This work enhances our understanding of what is critical for FtsZ function in vivo and highlights the need to develop better assays for evaluating FtsZ assembly in vitro. Advisors/Committee Members: Petra A Levin.

Subjects/Keywords: cell cycle; cell division; DNA replication; FtsZ

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Arjes, H. A. (2014). Failsafe Mechanisms Coordinate Cell Division and the Initiation of DNA Replication in Bacteria. (Doctoral Dissertation). Washington University in St. Louis. Retrieved from https://openscholarship.wustl.edu/etd/1280

Chicago Manual of Style (16^th Edition):

Arjes, Heidi Ann. “Failsafe Mechanisms Coordinate Cell Division and the Initiation of DNA Replication in Bacteria.” 2014. Doctoral Dissertation, Washington University in St. Louis. Accessed January 23, 2021. https://openscholarship.wustl.edu/etd/1280.

MLA Handbook (7^th Edition):

Arjes, Heidi Ann. “Failsafe Mechanisms Coordinate Cell Division and the Initiation of DNA Replication in Bacteria.” 2014. Web. 23 Jan 2021.

Vancouver:

Arjes HA. Failsafe Mechanisms Coordinate Cell Division and the Initiation of DNA Replication in Bacteria. [Internet] [Doctoral dissertation]. Washington University in St. Louis; 2014. [cited 2021 Jan 23]. Available from: https://openscholarship.wustl.edu/etd/1280.

Council of Science Editors:

Arjes HA. Failsafe Mechanisms Coordinate Cell Division and the Initiation of DNA Replication in Bacteria. [Doctoral Dissertation]. Washington University in St. Louis; 2014. Available from: https://openscholarship.wustl.edu/etd/1280

IUPUI

16. Rohrabaugh, Sara L. Effects of Altering Cell Proliferation on Hematopoietic Stem and Progenitor Cell Function.

Degree: 2011, IUPUI

URL: http://hdl.handle.net/1805/2599

►

Indiana University-Purdue University Indianapolis (IUPUI)

Cell cycle checkpoints guarantee movement through the cell cycle in an appropriate manner. The spindle assembly checkpoint (SAC) ensures the… (more)

▼

Indiana University-Purdue University Indianapolis (IUPUI)

Cell cycle checkpoints guarantee movement through the cell cycle in an appropriate manner. The spindle assembly checkpoint (SAC) ensures the proper segregation of chromosomes into daughter cells during mitosis. Mitotic arrest deficiency 2 (Mad2), a member of the mitotic checkpoint proteins, appears to be crucial for generating the wait anaphase signal to prevent onset of anaphase. We first studied the SAC in hematopoietic stem cells (HSC) to ensure that it was functional. Our previous studies found that prolonged SAC activation was uncoupled from apoptosis initiation in mouse and human embryonic stem cells (ESC). We found that upon treatment with a microtubule-destabilizing agent, HSC arrested in M-phase and subsequently initiated apoptosis. Thus unlike ESC, HSC exhibit coupling of prolonged SAC activation with apoptosis. We studied the effects of Mad2+/- on in vivo recovery of bone marrow HPC from cytotoxic effects and also effects of cytostatic agents on HPC growth in vitro using Mad2-haploinsufficient (Mad2+/-) mice. We found that Mad2+/- HPCs were protected from the cytotoxic effects of cytarabine (Ara-C), a cycle specific agent, consistent with Mad2+/- HPCs being in a slow or non-cycling state. Mad2 haploinsufficiency did not affect recovery of functional HPC after treatment with cyclophosphamide or high sub-lethal dose irradiation, both non-cycle specific agents. There were no differences in immunophenotype defined HSCs in Mad2+/- and Mad2+/+ mice, data confirmed by functional HSC competitive repopulation assays. To better understand the role of Mad2 in HPC, E3330, a cytostatic agent, was used to assess the redox function of Ape1/Ref-1, and colony formation in vitro was examined under normoxic and lowered O2 tension. Mad2+/- HPCs were less responsive to E3330 than Mad2+/+ HPCs, and E3330 was more effective under lowered O2 tension. Mad2+/- HPCs did not exhibit enhanced growth in lowered oxygen tension, in contrast to Mad2+/+ HPCs. Our studies have unexpectedly found that Mad2 haploinsufficiency is protective from the cytotoxic effects of a cycle specific DNA synthesis agent in vivo, and Ape1/Ref-1 inhibitor in vitro.

Advisors/Committee Members: Broxmeyer, Hal E., Pelus, Louis, Roman, Ann, Yoder, Mervin C..

Subjects/Keywords: hematopoietic stem cell, hematopoietic progenitor cell, cell cycle; Hematopoietic stem cells; Cell cycle – Regulation

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APA (6^th Edition):

Rohrabaugh, S. L. (2011). Effects of Altering Cell Proliferation on Hematopoietic Stem and Progenitor Cell Function. (Thesis). IUPUI. Retrieved from http://hdl.handle.net/1805/2599

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rohrabaugh, Sara L. “Effects of Altering Cell Proliferation on Hematopoietic Stem and Progenitor Cell Function.” 2011. Thesis, IUPUI. Accessed January 23, 2021. http://hdl.handle.net/1805/2599.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rohrabaugh, Sara L. “Effects of Altering Cell Proliferation on Hematopoietic Stem and Progenitor Cell Function.” 2011. Web. 23 Jan 2021.

Vancouver:

Rohrabaugh SL. Effects of Altering Cell Proliferation on Hematopoietic Stem and Progenitor Cell Function. [Internet] [Thesis]. IUPUI; 2011. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/1805/2599.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rohrabaugh SL. Effects of Altering Cell Proliferation on Hematopoietic Stem and Progenitor Cell Function. [Thesis]. IUPUI; 2011. Available from: http://hdl.handle.net/1805/2599

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Université de Grenoble

17. Vu Hong, Lien. Les Benzo[e]pyridoindoles, une nouvelle famille d'inhibiteurs de kinase à activité anti-proliférative : Benzo[e]pyridoindole, the novel kinase inhibitor family with antiproliferative activity.

Degree: Docteur es, Biologie cellulaire, 2011, Université de Grenoble

URL: http://www.theses.fr/2011GRENV049

►

Les Benzo[e]pyridoindoles sont identifiés comme inhibiteurs des kinases Aurora. La molécule la plus active, C1, inhibe efficacement à la fois Aurora B et CHK2. Nous… (more)

▼

Les Benzo[e]pyridoindoles sont identifiés comme inhibiteurs des kinases Aurora. La molécule la plus active, C1, inhibe efficacement à la fois Aurora B et CHK2. Nous avons donc exploité cette potentialité dans des applications de traitements combinés en se basant sur la spécificité restreinte mais multiple de cet inhibiteur. Nous avons mis en place le traitement combiné (Etoposide et C1) sur des lignées cellulaires et des effets additifs pour H358 et synergiques pour U2OS et HL60 sont notés. Ce traitement empêche efficacement la croissance des sphéroides et l'expansion des xénogreffes cellulaires. Un des avantages majeur de cette combinaison est la diminution des doses d'agents de dommages à l'ADN. C1 ouvre une piste pharmacologique basée sur l'altération simultanée de la mitose et de la réparation. La famille des benzo[e]pyridoindoles possède une forme penta-hétérocyclique avec 3 chaines latérales dont les variations peuvent influencer l'activité inhibitrice. Nous avons donc mesuré l'activité antimitotique de différents benzo[e]pyridoindoles. Cette étude structure/fonction permet de définir la contribution des chaînes latérales dans l'activité inhibitrice et d'orienter les futures synthèses. Nous nous sommes également intéressés au composé C4 qui avait un profil atypique d'inhibition de phosphorylation de l'histone H3. Il inhibe cette phosphorylation uniquement en entrée de mitose. Nous avons ainsi pu montrer que la phosphorylation de l'histone H3 n'est pas nécessaire à l'assemblage des chromosomes. Enfin, nous avons caractérisé l'efficacité de la molécule C21, un composé à forte activité anti-proliférative, sur différents modèles cellulaires et animaux. Ce travail révèle les potentialités multiples des benzo[e]pyridoindoles comme nouvelles molécules anti-prolifératives

Benzo[e]pyridoindole is identified as the novel Aurora inhibiteurs. The most potent compound, C1, inhibits efficiently both Aurora B and CHK2. Thus, we exploited the potency of this molecule in combined treatment applications based on its sharp and multiple specificities. We set up the combined treatments (Etoposide plus C1) on different cell lines and obtained an additive effect on H358 and a synergic one for HL60 and U2OS cells. This combination prevents the spheroid development as well as the cellular xenograft expansion. One of the main advantages of this combination is to decrease the dose of DNA damage agents in therapy leading to the reduction of their toxicity. C1 inhibiting both CHK2 and Aurora B open the way to targeted pharmacology based on simultaneous alteration of mitotic onset and DNA damage defences. Benzo[e]pyridoindole family has a penta-heterocyclic form with 3 lateral chains. The variations of these lateral chains can affect the inhibitory activity of the compounds. We researched the antimitotic efficiency of several benzo[e]pyridoindoles. This structure/function study drives to define the contribution of lateral chains in inhibitory activity and will direct future synthesis. We focused on compound C4 that induced an unusual…

Advisors/Committee Members: Molla, Annie (thesis director).

Subjects/Keywords: Mitose; Kinase; Cycle cellulaire; Cycle cellulaire; Kinase; Cell cycle; 570

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APA (6^th Edition):

Vu Hong, L. (2011). Les Benzo[e]pyridoindoles, une nouvelle famille d'inhibiteurs de kinase à activité anti-proliférative : Benzo[e]pyridoindole, the novel kinase inhibitor family with antiproliferative activity. (Doctoral Dissertation). Université de Grenoble. Retrieved from http://www.theses.fr/2011GRENV049

Chicago Manual of Style (16^th Edition):

Vu Hong, Lien. “Les Benzo[e]pyridoindoles, une nouvelle famille d'inhibiteurs de kinase à activité anti-proliférative : Benzo[e]pyridoindole, the novel kinase inhibitor family with antiproliferative activity.” 2011. Doctoral Dissertation, Université de Grenoble. Accessed January 23, 2021. http://www.theses.fr/2011GRENV049.

MLA Handbook (7^th Edition):

Vu Hong, Lien. “Les Benzo[e]pyridoindoles, une nouvelle famille d'inhibiteurs de kinase à activité anti-proliférative : Benzo[e]pyridoindole, the novel kinase inhibitor family with antiproliferative activity.” 2011. Web. 23 Jan 2021.

Vancouver:

Vu Hong L. Les Benzo[e]pyridoindoles, une nouvelle famille d'inhibiteurs de kinase à activité anti-proliférative : Benzo[e]pyridoindole, the novel kinase inhibitor family with antiproliferative activity. [Internet] [Doctoral dissertation]. Université de Grenoble; 2011. [cited 2021 Jan 23]. Available from: http://www.theses.fr/2011GRENV049.

Council of Science Editors:

Vu Hong L. Les Benzo[e]pyridoindoles, une nouvelle famille d'inhibiteurs de kinase à activité anti-proliférative : Benzo[e]pyridoindole, the novel kinase inhibitor family with antiproliferative activity. [Doctoral Dissertation]. Université de Grenoble; 2011. Available from: http://www.theses.fr/2011GRENV049

University of Toronto

18. Alexson, Tania O. Redefining Pluripotent Stem Cells: A Cell Cycle Perspective.

Degree: PhD, 2018, University of Toronto

URL: http://hdl.handle.net/1807/89792

► As it is classically defined, the term stem cell seems at odds with the process of early development where, at least initially, there are no… (more)

Subjects/Keywords: Cell Cycle; Cell Fate; Embryonic Stem Cell; Pluripotency; Stem Cell; 0758

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APA (6^th Edition):

Alexson, T. O. (2018). Redefining Pluripotent Stem Cells: A Cell Cycle Perspective. (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/89792

Chicago Manual of Style (16^th Edition):

Alexson, Tania O. “Redefining Pluripotent Stem Cells: A Cell Cycle Perspective.” 2018. Doctoral Dissertation, University of Toronto. Accessed January 23, 2021. http://hdl.handle.net/1807/89792.

MLA Handbook (7^th Edition):

Alexson, Tania O. “Redefining Pluripotent Stem Cells: A Cell Cycle Perspective.” 2018. Web. 23 Jan 2021.

Vancouver:

Alexson TO. Redefining Pluripotent Stem Cells: A Cell Cycle Perspective. [Internet] [Doctoral dissertation]. University of Toronto; 2018. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/1807/89792.

Council of Science Editors:

Alexson TO. Redefining Pluripotent Stem Cells: A Cell Cycle Perspective. [Doctoral Dissertation]. University of Toronto; 2018. Available from: http://hdl.handle.net/1807/89792

19. Keifenheim, Daniel L. Cell Size Control in the Fission Yeast Schizosaccharomyces pombe: A Dissertation.

Degree: Interdisciplinary Graduate Program, Biochemistry and Molecular Pharmacology, 2015, U of Massachusetts : Med

URL: http://escholarship.umassmed.edu/gsbs_diss/784

► The coordination between cell growth and division is a highly regulated process that is intimately linked to the cell cycle. Efforts to identify an… (more)

▼ The coordination between cell growth and division is a highly regulated process that is intimately linked to the cell cycle. Efforts to identify an independent mechanism that measures cell size have been unsuccessful. Instead, we propose that size control is an intrinsic function of the basic cell cycle machinery. My work shows that in the fission yeast Schizosaccharomyces pombe Cdc25 accumulates in a size dependent manner. This accumulation of Cdc25 occurs over a large range of cell sizes. Additionally, experiments with short pulses of cycloheximide have shown that Cdc25 is an inherently unstable protein that quickly returns to a size dependent equilibrium in the cell suggesting that Cdc25 concentration is dependent on size and not time. Thus, Cdc25 can act as a sizer for the cell. However, cells are still viable when Cdc25 is constitutively expressed suggesting that there is another sizer in the case that Cdc25 expression is compromised. Cdc13 is a likely candidate due to the similar characteristics to Cdc25 and the ability to activate Cdc2. Cdc13 accumulates during the cell cycle in a manner similar to Cdc25. I show that in the absence of Cdc2 tyrosine phosphorylation, the cell size is sensitive to Cdc13 activity showing that Cdc13 accumulation can determine when cells enter mitosis. These results suggest a two sizer model where Cdc25 is the main sizer with Cdc13 acting as a backup sizer in the event of Cdc25 expression is compromised. Additionally, in the absence of Cdc2 phosphorylation by the kinases Wee1 and Mik1, mitotic entry is regulated by the activity of Cdc2. In the absence of Cdc2 phosphorylation, this activity is regulated by binding of cyclins to Cdc2. Under these circumstances, the activity of Cdc13 can regulate mitotic entry provide further evidence that Cdc13 could be a sizer of the cell in the case where Cdc25 expression is compromised. The results I present in this dissertation provide the groundwork for understanding how cells regulate size and how this size regulation affects cell cycle control in S. pombe . The results show how the intrinsic cell cycle machinery can act as a sizer for the G2/M transition in S. pombe . Interestingly, this mitotic commitment pathway is well conserved suggesting a general solution for size control in eukaryotes at the G2/M transition. Understanding the mechanism of how protein concentration is regulated in a size dependent manner will give much needed insight into how cells control size. Elucidating the mechanism for size control will capitalize on decades of research and deepen our understanding of basic cell biology. Advisors/Committee Members: Nick Rhind, PhD.

Subjects/Keywords: Cell Size; Cell Cycle; Cell Cycle Checkpoints; Cell Division; Schizosaccharomyces; Cell Biology; Cellular and Molecular Physiology

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APA (6^th Edition):

Keifenheim, D. L. (2015). Cell Size Control in the Fission Yeast Schizosaccharomyces pombe: A Dissertation. (Doctoral Dissertation). U of Massachusetts : Med. Retrieved from http://escholarship.umassmed.edu/gsbs_diss/784

Chicago Manual of Style (16^th Edition):

Keifenheim, Daniel L. “Cell Size Control in the Fission Yeast Schizosaccharomyces pombe: A Dissertation.” 2015. Doctoral Dissertation, U of Massachusetts : Med. Accessed January 23, 2021. http://escholarship.umassmed.edu/gsbs_diss/784.

MLA Handbook (7^th Edition):

Keifenheim, Daniel L. “Cell Size Control in the Fission Yeast Schizosaccharomyces pombe: A Dissertation.” 2015. Web. 23 Jan 2021.

Vancouver:

Keifenheim DL. Cell Size Control in the Fission Yeast Schizosaccharomyces pombe: A Dissertation. [Internet] [Doctoral dissertation]. U of Massachusetts : Med; 2015. [cited 2021 Jan 23]. Available from: http://escholarship.umassmed.edu/gsbs_diss/784.

Council of Science Editors:

Keifenheim DL. Cell Size Control in the Fission Yeast Schizosaccharomyces pombe: A Dissertation. [Doctoral Dissertation]. U of Massachusetts : Med; 2015. Available from: http://escholarship.umassmed.edu/gsbs_diss/784

University of Illinois – Chicago

20. Rady, Brian. Transcription Factors E2F Have a Role in Proliferation of Beta-Cells and Development of Type-2 Diabetes.

Degree: 2013, University of Illinois – Chicago

URL: http://hdl.handle.net/10027/10071

► This work pertains to the search for genetic targets to induce beta-cell proliferation. This proliferation was intended to support the advancement of islet cell transplant… (more)

Subjects/Keywords: Diabetes; cell therapy; beta-cell proliferation; cell-cycle

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APA (6^th Edition):

Rady, B. (2013). Transcription Factors E2F Have a Role in Proliferation of Beta-Cells and Development of Type-2 Diabetes. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/10071

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rady, Brian. “Transcription Factors E2F Have a Role in Proliferation of Beta-Cells and Development of Type-2 Diabetes.” 2013. Thesis, University of Illinois – Chicago. Accessed January 23, 2021. http://hdl.handle.net/10027/10071.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rady, Brian. “Transcription Factors E2F Have a Role in Proliferation of Beta-Cells and Development of Type-2 Diabetes.” 2013. Web. 23 Jan 2021.

Vancouver:

Rady B. Transcription Factors E2F Have a Role in Proliferation of Beta-Cells and Development of Type-2 Diabetes. [Internet] [Thesis]. University of Illinois – Chicago; 2013. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/10027/10071.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rady B. Transcription Factors E2F Have a Role in Proliferation of Beta-Cells and Development of Type-2 Diabetes. [Thesis]. University of Illinois – Chicago; 2013. Available from: http://hdl.handle.net/10027/10071

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

21. Li, Yi-Jin. The Molecular Study of Fluoxetine Induces Cell Cycle Arrest and Apoptosis in Pancreatic Cancer Cells.

Degree: Master, Institute of Biomedical Sciences, 2014, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0513114-143723

► Fluoxetine (FLX) is a commonly antidepressant for oral administration and belonging to the selective serotonin reuptake inhibitors (SSRI), which is used for the treatment of… (more)

Subjects/Keywords: migration; proliferation; Pancreatic cancer; apoptosis; cell cycle

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APA (6^th Edition):

Li, Y. (2014). The Molecular Study of Fluoxetine Induces Cell Cycle Arrest and Apoptosis in Pancreatic Cancer Cells. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0513114-143723

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Li, Yi-Jin. “The Molecular Study of Fluoxetine Induces Cell Cycle Arrest and Apoptosis in Pancreatic Cancer Cells.” 2014. Thesis, NSYSU. Accessed January 23, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0513114-143723.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Li, Yi-Jin. “The Molecular Study of Fluoxetine Induces Cell Cycle Arrest and Apoptosis in Pancreatic Cancer Cells.” 2014. Web. 23 Jan 2021.

Vancouver:

Li Y. The Molecular Study of Fluoxetine Induces Cell Cycle Arrest and Apoptosis in Pancreatic Cancer Cells. [Internet] [Thesis]. NSYSU; 2014. [cited 2021 Jan 23]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0513114-143723.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Li Y. The Molecular Study of Fluoxetine Induces Cell Cycle Arrest and Apoptosis in Pancreatic Cancer Cells. [Thesis]. NSYSU; 2014. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0513114-143723

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universiteit Utrecht

22. Boekhout, M. APC/C activity during the cell cycle. Shifting gears in protein degradation.

Degree: 2015, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/320237

► For correct cell division to take place, many different mechanisms ensure genomic integrity and formation healthy daughter cells. One mechanism that has evolved to provide… (more)

▼ For correct cell division to take place, many different mechanisms ensure genomic integrity and formation healthy daughter cells. One mechanism that has evolved to provide a safe passage from one cell cycle phase into the next, is protein degradation. With our work we provide new insights into activity and regulation of one of the major protein complexes responsible for protein degradation, the APC/C. It targets many different proteins at several points during the cell cycle for destruction. Degradation of these substrates is dependent on recognition motifs in their sequence, known as 'degrons', however they can also depend on targeting tails to directly bind the APC/C. Interestingly, the APC/C requires one of two coactivators to become active and destroy proteins. These activators, known as Cdc20 and Cdh1, play a role during different phases of the cell cycle, and are also subject to different specific inhibitors, to prevent precocious APC/C activity. We find that Nek2A is the most sensitive APC/C substrate to date, which is degraded upon APC/C activation by Cdc20 upon entry into mitosis, even if Cdc20 is almost completely blocked by inhibitors. We further find that Nek2A is so sensitive to APC/C activity that even before mitosis, Cdh1 is responsible for degradation, again while other substrates are not targeted for destruction due to the inhibitory protein Emi1. Furthermore, we show that at the end of G1, two transcription factors are novel substrates, and must be degraded by the APC/C to start replication of the DNA in S-phase. Failure to degrade these proteins leads to cell cycle halt and eventually cell death. Based on Emi1, we have developed an inducible APC/C inhibitor. APC/C activity is most prominent during mitosis when it is required to progress cells from metaphase to anapahase, after mitotic checkpoint satisfaction. Using this novel tool we can arrest several different cellines for a prolonged time in metaphase, by directly blocking the APC/C, largely independent of the mitotic checkpoint. This offers new and exciting possibilities for further studying the APC/C. Advisors/Committee Members: Bernards, R.A., Wolthuis, R.M.F..

Subjects/Keywords: APC/C; cell cycle; Cdc20; Cdh1; Nek2A

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Boekhout, M. (2015). APC/C activity during the cell cycle. Shifting gears in protein degradation. (Doctoral Dissertation). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/320237

Chicago Manual of Style (16^th Edition):

Boekhout, M. “APC/C activity during the cell cycle. Shifting gears in protein degradation.” 2015. Doctoral Dissertation, Universiteit Utrecht. Accessed January 23, 2021. http://dspace.library.uu.nl:8080/handle/1874/320237.

MLA Handbook (7^th Edition):

Boekhout, M. “APC/C activity during the cell cycle. Shifting gears in protein degradation.” 2015. Web. 23 Jan 2021.

Vancouver:

Boekhout M. APC/C activity during the cell cycle. Shifting gears in protein degradation. [Internet] [Doctoral dissertation]. Universiteit Utrecht; 2015. [cited 2021 Jan 23]. Available from: http://dspace.library.uu.nl:8080/handle/1874/320237.

Council of Science Editors:

Boekhout M. APC/C activity during the cell cycle. Shifting gears in protein degradation. [Doctoral Dissertation]. Universiteit Utrecht; 2015. Available from: http://dspace.library.uu.nl:8080/handle/1874/320237

Dalhousie University

23. O'Brien, Michael. CHARACTERIZATION OF A NOVEL ISOFORM OF NOS1AP: NOS1APc.

Degree: MS, Department of Pharmacology, 2012, Dalhousie University

URL: http://hdl.handle.net/10222/15490

► The current study characterizes a novel isoform of the Nitric Oxide Synthase 1 Adaptor Protein (NOS1AP), herein NOS1APc. NOS1APc was identified in a proteomic screen… (more)

Subjects/Keywords: NOS1AP; NOS1APc; Scribble; cerebellum; cell cycle

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APA (6^th Edition):

O'Brien, M. (2012). CHARACTERIZATION OF A NOVEL ISOFORM OF NOS1AP: NOS1APc. (Masters Thesis). Dalhousie University. Retrieved from http://hdl.handle.net/10222/15490

Chicago Manual of Style (16^th Edition):

O'Brien, Michael. “CHARACTERIZATION OF A NOVEL ISOFORM OF NOS1AP: NOS1APc.” 2012. Masters Thesis, Dalhousie University. Accessed January 23, 2021. http://hdl.handle.net/10222/15490.

MLA Handbook (7^th Edition):

O'Brien, Michael. “CHARACTERIZATION OF A NOVEL ISOFORM OF NOS1AP: NOS1APc.” 2012. Web. 23 Jan 2021.

Vancouver:

O'Brien M. CHARACTERIZATION OF A NOVEL ISOFORM OF NOS1AP: NOS1APc. [Internet] [Masters thesis]. Dalhousie University; 2012. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/10222/15490.

Council of Science Editors:

O'Brien M. CHARACTERIZATION OF A NOVEL ISOFORM OF NOS1AP: NOS1APc. [Masters Thesis]. Dalhousie University; 2012. Available from: http://hdl.handle.net/10222/15490

24. MORITA, HIROSHI. Characterization of phosphodiesterase 2A in human malignant melanoma PMP cells.

Degree: 博士(医学), 2017, Mie University / 三重大学

URL: http://hdl.handle.net/10076/13987

►

The prognosis for malignant melanoma is poor; therefore, new diagnostic methods and treatment strategies are urgently needed. Phosphodiesterase 2 (PDE2) is one of 21 phosphodiesterases,… (more)

▼

The prognosis for malignant melanoma is poor; therefore, new diagnostic methods and treatment strategies are urgently needed. Phosphodiesterase 2 (PDE2) is one of 21 phosphodiesterases, which are divided into 11 families (PDE1-PDE11). PDE2 hydrolyzes cyclic AMP (cAMP) and cyclic GMP (cGMP), and its binding to cGMP enhances the hydrolysis of cAMP. We previously reported the expression of PDE1, PDE3 and PDE5 in human malignant melanoma cells. However, the expression of PDE2 in these cells has not been investigated. Herein, we examined the expression of PDE2A and its role in human oral malignant melanoma PMP cells. Sequencing of RT-PCR products revealed that PDE2A2 was the only variant expressed in PMP cells. Four point mutations were detected; one missense mutation at nucleotide position 734 (from C to T) resulted in the substitution of threonine with isoleucine at amino acid position 214. The other three were silent mutations. An in vitro migration assay and a terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling assay revealed that suppressing PDE2 activity with its specific inhibitor, erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA), had no impact on cell motility or apoptosis. Furthermore, the cytotoxicity of EHNA, assessed using a trypan blue exclusion assay, was negligible. On the other hand, assessment of cell proliferation by BrdU incorporation and cell cycle analysis by flow cytometry revealed that EHNA treatment inhibited DNA synthesis and increased the percentage of G2/M-arrested cells. Furthermore, cyclin A mRNA expression was downregulated, while cyclin E mRNA expression was upregulated in EHNA-treated cells. Our results demonstrated that the PDE2A2 variant carrying point mutations is expressed in PMP cells and may affect cell cycle progression by modulating cyclin A expression. Thus, PDE2A2 is a possible new molecular target for the treatment of malignant melanoma.

本文 / Department of Oral and Maxillofacial Surgery, Department of Clinical Sciences,Medical Life Science, Mie University Graduate School of Medicine

10

Subjects/Keywords: malignant melanoma; phosphodiesterase 2A; cell cycle

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APA (6^th Edition):

MORITA, H. (2017). Characterization of phosphodiesterase 2A in human malignant melanoma PMP cells. (Thesis). Mie University / 三重大学. Retrieved from http://hdl.handle.net/10076/13987

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

MORITA, HIROSHI. “Characterization of phosphodiesterase 2A in human malignant melanoma PMP cells.” 2017. Thesis, Mie University / 三重大学. Accessed January 23, 2021. http://hdl.handle.net/10076/13987.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

MORITA, HIROSHI. “Characterization of phosphodiesterase 2A in human malignant melanoma PMP cells.” 2017. Web. 23 Jan 2021.

Vancouver:

MORITA H. Characterization of phosphodiesterase 2A in human malignant melanoma PMP cells. [Internet] [Thesis]. Mie University / 三重大学; 2017. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/10076/13987.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

MORITA H. Characterization of phosphodiesterase 2A in human malignant melanoma PMP cells. [Thesis]. Mie University / 三重大学; 2017. Available from: http://hdl.handle.net/10076/13987

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

25. Barnes, Blake Heim. Expression and Purification of Toxoplasma gondii Cell Cycle Regulation Proteins.

Degree: Biological Sciences - Cell and Molecular: M.S., Biology, 2016, St. Cloud State University

URL: https://repository.stcloudstate.edu/biol_etds/13

► Toxoplasma gondii is an Apicomplexan obligate intracellular protozoan parasite, which is able to infect virtually all warm-blooded animals. According to the Centers for Disease… (more)

Subjects/Keywords: Toxoplasma; Apicomplexa; Cell Cycle; Regulation; Proteins

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APA (6^th Edition):

Barnes, B. H. (2016). Expression and Purification of Toxoplasma gondii Cell Cycle Regulation Proteins. (Masters Thesis). St. Cloud State University. Retrieved from https://repository.stcloudstate.edu/biol_etds/13

Chicago Manual of Style (16^th Edition):

Barnes, Blake Heim. “Expression and Purification of Toxoplasma gondii Cell Cycle Regulation Proteins.” 2016. Masters Thesis, St. Cloud State University. Accessed January 23, 2021. https://repository.stcloudstate.edu/biol_etds/13.

MLA Handbook (7^th Edition):

Barnes, Blake Heim. “Expression and Purification of Toxoplasma gondii Cell Cycle Regulation Proteins.” 2016. Web. 23 Jan 2021.

Vancouver:

Barnes BH. Expression and Purification of Toxoplasma gondii Cell Cycle Regulation Proteins. [Internet] [Masters thesis]. St. Cloud State University; 2016. [cited 2021 Jan 23]. Available from: https://repository.stcloudstate.edu/biol_etds/13.

Council of Science Editors:

Barnes BH. Expression and Purification of Toxoplasma gondii Cell Cycle Regulation Proteins. [Masters Thesis]. St. Cloud State University; 2016. Available from: https://repository.stcloudstate.edu/biol_etds/13

University of Utah

26. Kang, Hara. Cell Cycle, Fate, Stem Cells, and the Planarian Schmidtea Mediterranea.

Degree: PhD, Neurobiology & Anatomy;, 2010, University of Utah

URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1379/rec/186

► The replacement of differentiated cells is a major challenge for all multicellular organisms throughout their life spans. Humans, for example, must replace an estimated 10… (more)

Subjects/Keywords: Cell Cycle; Planaria as Laboratory Animals

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APA (6^th Edition):

Kang, H. (2010). Cell Cycle, Fate, Stem Cells, and the Planarian Schmidtea Mediterranea. (Doctoral Dissertation). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1379/rec/186

Chicago Manual of Style (16^th Edition):

Kang, Hara. “Cell Cycle, Fate, Stem Cells, and the Planarian Schmidtea Mediterranea.” 2010. Doctoral Dissertation, University of Utah. Accessed January 23, 2021. http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1379/rec/186.

MLA Handbook (7^th Edition):

Kang, Hara. “Cell Cycle, Fate, Stem Cells, and the Planarian Schmidtea Mediterranea.” 2010. Web. 23 Jan 2021.

Vancouver:

Kang H. Cell Cycle, Fate, Stem Cells, and the Planarian Schmidtea Mediterranea. [Internet] [Doctoral dissertation]. University of Utah; 2010. [cited 2021 Jan 23]. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1379/rec/186.

Council of Science Editors:

Kang H. Cell Cycle, Fate, Stem Cells, and the Planarian Schmidtea Mediterranea. [Doctoral Dissertation]. University of Utah; 2010. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1379/rec/186

NSYSU

27. Jhung, Jheng-Yan. Studies on the oncogene of BCl6 effect in human bladder cancer cell lines through FOXO signaling pathway.

Degree: Master, Institute of Biomedical Sciences, 2017, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0806117-173323

► Bladder cancer is derived from urothelial, called urothelial carcinoma. Itâs the most top ten cancer in Taiwan. In addition, the cancer with high mortality rate… (more)

Subjects/Keywords: FOXO3; BCL6; Urothelial; Cell cycle; bladder cancer

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APA (6^th Edition):

Jhung, J. (2017). Studies on the oncogene of BCl6 effect in human bladder cancer cell lines through FOXO signaling pathway. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0806117-173323

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jhung, Jheng-Yan. “Studies on the oncogene of BCl6 effect in human bladder cancer cell lines through FOXO signaling pathway.” 2017. Thesis, NSYSU. Accessed January 23, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0806117-173323.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jhung, Jheng-Yan. “Studies on the oncogene of BCl6 effect in human bladder cancer cell lines through FOXO signaling pathway.” 2017. Web. 23 Jan 2021.

Vancouver:

Jhung J. Studies on the oncogene of BCl6 effect in human bladder cancer cell lines through FOXO signaling pathway. [Internet] [Thesis]. NSYSU; 2017. [cited 2021 Jan 23]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0806117-173323.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jhung J. Studies on the oncogene of BCl6 effect in human bladder cancer cell lines through FOXO signaling pathway. [Thesis]. NSYSU; 2017. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0806117-173323

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Kyoto University / 京都大学

28. Kawatsuki, Akihiro. HTLV-1 bZIP factor protein targets the Rb/E2F-1 pathway to promote proliferation and apoptosis of primary CD4+ T cells : HTLV-1 bZIP factorタンパク質はRb/E2F-1経路を標的とし、CD4陽性T細胞の増殖とアポトーシスを促進する.

Degree: 博士(医学), 2016, Kyoto University / 京都大学

URL: http://hdl.handle.net/2433/215441 ; http://dx.doi.org/10.14989/doctor.k19615

►

The author’s accepted version (the unedited manuscript) may be deposited into a repository six months after print publication. In this case, authors should cite the… (more)

Subjects/Keywords: HTLV-1; cell cycle; cancer; apoptosis; retrovirus

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APA (6^th Edition):

Kawatsuki, A. (2016). HTLV-1 bZIP factor protein targets the Rb/E2F-1 pathway to promote proliferation and apoptosis of primary CD4+ T cells : HTLV-1 bZIP factorタンパク質はRb/E2F-1経路を標的とし、CD4陽性T細胞の増殖とアポトーシスを促進する. (Thesis). Kyoto University / 京都大学. Retrieved from http://hdl.handle.net/2433/215441 ; http://dx.doi.org/10.14989/doctor.k19615

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kawatsuki, Akihiro. “HTLV-1 bZIP factor protein targets the Rb/E2F-1 pathway to promote proliferation and apoptosis of primary CD4+ T cells : HTLV-1 bZIP factorタンパク質はRb/E2F-1経路を標的とし、CD4陽性T細胞の増殖とアポトーシスを促進する.” 2016. Thesis, Kyoto University / 京都大学. Accessed January 23, 2021. http://hdl.handle.net/2433/215441 ; http://dx.doi.org/10.14989/doctor.k19615.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kawatsuki, Akihiro. “HTLV-1 bZIP factor protein targets the Rb/E2F-1 pathway to promote proliferation and apoptosis of primary CD4+ T cells : HTLV-1 bZIP factorタンパク質はRb/E2F-1経路を標的とし、CD4陽性T細胞の増殖とアポトーシスを促進する.” 2016. Web. 23 Jan 2021.

Vancouver:

Kawatsuki A. HTLV-1 bZIP factor protein targets the Rb/E2F-1 pathway to promote proliferation and apoptosis of primary CD4+ T cells : HTLV-1 bZIP factorタンパク質はRb/E2F-1経路を標的とし、CD4陽性T細胞の増殖とアポトーシスを促進する. [Internet] [Thesis]. Kyoto University / 京都大学; 2016. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/2433/215441 ; http://dx.doi.org/10.14989/doctor.k19615.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kawatsuki A. HTLV-1 bZIP factor protein targets the Rb/E2F-1 pathway to promote proliferation and apoptosis of primary CD4+ T cells : HTLV-1 bZIP factorタンパク質はRb/E2F-1経路を標的とし、CD4陽性T細胞の増殖とアポトーシスを促進する. [Thesis]. Kyoto University / 京都大学; 2016. Available from: http://hdl.handle.net/2433/215441 ; http://dx.doi.org/10.14989/doctor.k19615

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Georgia

29. Blythe, Brad James. Diel characteristics of Prochlorococcus and Synechococcus populations in the western Sargasso Sea.

Degree: 2014, University of Georgia

URL: http://hdl.handle.net/10724/25132

► Prochlorococcus and Synechococcus are ubiquitous marine icocyanobacteria that contribute significantly to oceanic primary production. The tightly phased patterns of cell growth and division in these… (more)

▼ Prochlorococcus and Synechococcus are ubiquitous marine icocyanobacteria that contribute significantly to oceanic primary production. The tightly phased patterns of cell growth and division in these groups provide a basis for evaluating their in situ growth and mortality. In particular, the daily progression of Prochlorococcus populations through their cell cycle can be used to estimate the growth rate (and by inference, the loss rate) of these populations. In this dissertation, the diel dynamics of cell abundance, cellular growth, and cell cycle progression are presented for Prochlorococcus and Synechococcus populations in the Western Sargasso Sea. I use these data to critically evaluate two methods of calculating in situ growth rates of Prochlorococcus populations in this environment. I also utilize concurrently sampled incubation bottles to test the efficacy of commonly used incubation techniques to accurately simulate the dynamics of natural picoplankton populations. Finally, I report on a numerical simulation model of Prochlorococcus based on the current state of knowledge of the biology and ecology of these organisms. My results demonstrate that while as a group Prochlorococcus growth rates estimated by the two cell cycle-based approaches do not vary systematically, individual estimates can differ significantly between these two approaches. Growth rates varied widely over depth and between stations; no significant seasonality was detected. Regarding the bottle incubations, the physiology of in situ Prochlorococcus populations (as reflected in growth rate) appears to be reasonably reflected in the bottles. In contrast, grazing on Prochlorococcus was dramatically reduced in the bottles, relative to the in situ rates. Thus, traditional bottle incubations may not accurately replicate the ecological dynamics of in situ populations. Finally, the biology-based cell cycle model produced diel patterns in cell size and cell cycle dynamics that were qualitatively similar to those observed in natural populations. The model predicted strong day to day variability in these dynamics, and in the resultant growth rates, suggesting that estimates based on 24 h sampling may not accurately reflect the true growth rate of these populations on ecologically relevant time scales.

Subjects/Keywords: Cyanobacteria; Sargasso Sea; Cell Cycle; Flow Cytometry

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APA (6^th Edition):

Blythe, B. J. (2014). Diel characteristics of Prochlorococcus and Synechococcus populations in the western Sargasso Sea. (Thesis). University of Georgia. Retrieved from http://hdl.handle.net/10724/25132

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Blythe, Brad James. “Diel characteristics of Prochlorococcus and Synechococcus populations in the western Sargasso Sea.” 2014. Thesis, University of Georgia. Accessed January 23, 2021. http://hdl.handle.net/10724/25132.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Blythe, Brad James. “Diel characteristics of Prochlorococcus and Synechococcus populations in the western Sargasso Sea.” 2014. Web. 23 Jan 2021.

Vancouver:

Blythe BJ. Diel characteristics of Prochlorococcus and Synechococcus populations in the western Sargasso Sea. [Internet] [Thesis]. University of Georgia; 2014. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/10724/25132.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Blythe BJ. Diel characteristics of Prochlorococcus and Synechococcus populations in the western Sargasso Sea. [Thesis]. University of Georgia; 2014. Available from: http://hdl.handle.net/10724/25132

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Georgia

30. Gordon, Shira D. Polyembryonic proliferation.

Degree: 2014, University of Georgia

URL: http://hdl.handle.net/10724/23122

► Polyembryonic wasps are parasitoids that lay their eggs inside the bodies of other insects. These eggs then undergo a clonal phase of development that results… (more)

Subjects/Keywords: Polyembryony; proliferation; branchless; trachea; cell cycle

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gordon, S. D. (2014). Polyembryonic proliferation. (Thesis). University of Georgia. Retrieved from http://hdl.handle.net/10724/23122

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gordon, Shira D. “Polyembryonic proliferation.” 2014. Thesis, University of Georgia. Accessed January 23, 2021. http://hdl.handle.net/10724/23122.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gordon, Shira D. “Polyembryonic proliferation.” 2014. Web. 23 Jan 2021.

Vancouver:

Gordon SD. Polyembryonic proliferation. [Internet] [Thesis]. University of Georgia; 2014. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/10724/23122.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gordon SD. Polyembryonic proliferation. [Thesis]. University of Georgia; 2014. Available from: http://hdl.handle.net/10724/23122

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Open Access Theses and Dissertations