subject:(cancer)

1. Fergione, Sarah J. Engineering 3D Human Cortical Microtissues Harboring Patient-Derived Glioblastomas.

Degree: Department of Molecular Pharmacology, Physiology and Biotechnology, 2018, Brown University

URL: https://repository.library.brown.edu/studio/item/bdr:792897/

► Human glioblastomas develop within the brain parenchyma in which there is continuous interaction of glioma cells with axon fibers, glial cells and endothelial cells. This… (more)

▼ Human glioblastomas develop within the brain parenchyma in which there is continuous interaction of glioma cells with axon fibers, glial cells and endothelial cells. This cellular interplay cannot be accounted for with the current monolayer in vitro models. Moreover, the development of new therapies against glioblastoma has often failed due to toxicities that were not identified through in vitro studies and animal testing. To mitigate some of these limitations, we have developed an all human ex vivo 3D glioblastoma model. ReNcell CX cells, an immortalized human neural progenitor cell line, were used as the base of the 3D model. ReNcell CX cells were seeded into micromolds to form self-assembled spheroids and subsequently induced to differentiate. After 46 days of differentiation, spheroids were fixed, embedded, and cryosectioned for immunostaining to confirm assembly of polarized cortical microtissues. N-cadherin is essential for maintaining the polarized architecture of neuroepithelial cells in the cerebral cortex through the formation of adherent junctions. We show that our human cortical spheroids express N-cadherin in a polarized pattern close to the apical surface of the spheroids. To verify the presence of neocortical progenitors we stained with Pax6, while the presence of mature cortical neurons was verified with TuJ and Bf1 staining. To investigate the invasion of glioma cells into the human cortical spheroids, a confrontation assay between cortical and glioma spheroids was implemented. Finally, spheroids were fixed and stained using combinations of glioma cell and cortical neuron specific markers. The proposed model aims to mitigate some of the limitations in current in vitro and in vivo approaches. Our 3D human brain microtissues will be used to gain a more in-depth understanding of the origins of brain cancer, including the migration and invasion of glioblastoma into the brain parenchyma, and serve as drug development platform to test novel cancer therapeutics. Advisors/Committee Members: Morgan, Jeff (Advisor), Ip, Blanche (Reader), Tapinos, Nikos (Advisor).

Subjects/Keywords: Cancer

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APA (6^th Edition):

Fergione, S. J. (2018). Engineering 3D Human Cortical Microtissues Harboring Patient-Derived Glioblastomas. (Thesis). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:792897/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Fergione, Sarah J. “Engineering 3D Human Cortical Microtissues Harboring Patient-Derived Glioblastomas.” 2018. Thesis, Brown University. Accessed April 21, 2021. https://repository.library.brown.edu/studio/item/bdr:792897/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Fergione, Sarah J. “Engineering 3D Human Cortical Microtissues Harboring Patient-Derived Glioblastomas.” 2018. Web. 21 Apr 2021.

Vancouver:

Fergione SJ. Engineering 3D Human Cortical Microtissues Harboring Patient-Derived Glioblastomas. [Internet] [Thesis]. Brown University; 2018. [cited 2021 Apr 21]. Available from: https://repository.library.brown.edu/studio/item/bdr:792897/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Fergione SJ. Engineering 3D Human Cortical Microtissues Harboring Patient-Derived Glioblastomas. [Thesis]. Brown University; 2018. Available from: https://repository.library.brown.edu/studio/item/bdr:792897/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

2. Smith, Tyler. The Role of the Transcription Factor SREBP2 in Glioblastoma Cancer Cells.

Degree: Biomedical Engineering, 2017, Brown University

URL: https://repository.library.brown.edu/studio/item/bdr:733518/

► Abstract of The Role of the Transcription Factor SREBP2 in Glioblastoma Cancer Cells, by Tyler Smith, ScM., Brown University, May 2018. Cholesterol is a vital… (more)

Subjects/Keywords: Cancer

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APA (6^th Edition):

Smith, T. (2017). The Role of the Transcription Factor SREBP2 in Glioblastoma Cancer Cells. (Thesis). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:733518/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Smith, Tyler. “The Role of the Transcription Factor SREBP2 in Glioblastoma Cancer Cells.” 2017. Thesis, Brown University. Accessed April 21, 2021. https://repository.library.brown.edu/studio/item/bdr:733518/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Smith, Tyler. “The Role of the Transcription Factor SREBP2 in Glioblastoma Cancer Cells.” 2017. Web. 21 Apr 2021.

Vancouver:

Smith T. The Role of the Transcription Factor SREBP2 in Glioblastoma Cancer Cells. [Internet] [Thesis]. Brown University; 2017. [cited 2021 Apr 21]. Available from: https://repository.library.brown.edu/studio/item/bdr:733518/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Smith T. The Role of the Transcription Factor SREBP2 in Glioblastoma Cancer Cells. [Thesis]. Brown University; 2017. Available from: https://repository.library.brown.edu/studio/item/bdr:733518/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

3. Graham, Elizabeth Grace. Polymer Dynamic Organic Theranostic Spheres for Photothermal Therapy and Fluorescent Imaging of Cancer.

Degree: 2015, Wake Forest University

URL: http://hdl.handle.net/10339/57185

► Nanoparticle mediated photothermal ablation of cancer is a promising technique that utilizes light energy to destroy cancer cells. Specifically, nanoparticles that absorb in the near… (more)

Subjects/Keywords: cancer

11 more images…

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APA (6^th Edition):

Graham, E. G. (2015). Polymer Dynamic Organic Theranostic Spheres for Photothermal Therapy and Fluorescent Imaging of Cancer. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/57185

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Graham, Elizabeth Grace. “Polymer Dynamic Organic Theranostic Spheres for Photothermal Therapy and Fluorescent Imaging of Cancer.” 2015. Thesis, Wake Forest University. Accessed April 21, 2021. http://hdl.handle.net/10339/57185.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Graham, Elizabeth Grace. “Polymer Dynamic Organic Theranostic Spheres for Photothermal Therapy and Fluorescent Imaging of Cancer.” 2015. Web. 21 Apr 2021.

Vancouver:

Graham EG. Polymer Dynamic Organic Theranostic Spheres for Photothermal Therapy and Fluorescent Imaging of Cancer. [Internet] [Thesis]. Wake Forest University; 2015. [cited 2021 Apr 21]. Available from: http://hdl.handle.net/10339/57185.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Graham EG. Polymer Dynamic Organic Theranostic Spheres for Photothermal Therapy and Fluorescent Imaging of Cancer. [Thesis]. Wake Forest University; 2015. Available from: http://hdl.handle.net/10339/57185

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Debrecen

4. Gurpinar, Melisa. Different Types of Cancer .

Degree: DE – TEK – Természettudományi és Technológiai Kar – Biológiai és Ökológiai Intézet, 2012, University of Debrecen

URL: http://hdl.handle.net/2437/128533

Cancer is a leading cause of death worldwide and according to WHO (World Health Organisation) 7.6 million people worldwide died from cancer in 2008, and 30% of cancer could be prevented. Advisors/Committee Members: Bánfalvi, Gáspár (advisor).

Subjects/Keywords: Cancer

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APA (6^th Edition):

Gurpinar, M. (2012). Different Types of Cancer . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/128533

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gurpinar, Melisa. “Different Types of Cancer .” 2012. Thesis, University of Debrecen. Accessed April 21, 2021. http://hdl.handle.net/2437/128533.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gurpinar, Melisa. “Different Types of Cancer .” 2012. Web. 21 Apr 2021.

Vancouver:

Gurpinar M. Different Types of Cancer . [Internet] [Thesis]. University of Debrecen; 2012. [cited 2021 Apr 21]. Available from: http://hdl.handle.net/2437/128533.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gurpinar M. Different Types of Cancer . [Thesis]. University of Debrecen; 2012. Available from: http://hdl.handle.net/2437/128533

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Melbourne

5. Cheung, Vanessa. The role of PTHrP and Apo2L/TRAIL in breast cancer.

Degree: 2012, University of Melbourne

URL: http://hdl.handle.net/11343/37379

► Parathyroid hormone-related protein (PTHrP) is a key component in breast tumour biology. PTHrP is one of the main factors implicated in breast cancer osteolysis. Clinical… (more)

▼ Parathyroid hormone-related protein (PTHrP) is a key component in breast tumour biology. PTHrP is one of the main factors implicated in breast cancer osteolysis. Clinical studies have determined that PTHrP expression by primary breast cancers was an independent predictor of improved prognosis. Furthermore, PTHrP has been described to cause tumour cell death both in vitro and in vivo. A promising new anti-cancer agent is Apo2L/TRAIL due to its ability to selectively induce apoptosis in cancer cells whilst sparing most normal cells. However, some cancer cells are resistant to Apo2L/TRAIL-induced apoptosis thus limiting its therapeutic efficacy. Since both PTHrP and Apo2L/TRAIL has profound effects on breast cancer, the actions of these two factors were assessed. The effect of PTHrP on gene expression in breast cancer cells was studied. PTHrP was overexpressed in two breast cancer cell lines; MCF-7 and MDA-MB-231, and knocked down in MDA-MB-231, and analysed gene expression by microarray analysis. Cytochrome p450 1B1 (CYP1B1) was identified as a potential factor differentially altered by PTHrP in breast cancer cells. To assess the relationship of PTHrP with factors in the cell death pathways, PTHrP overexpressing breast cancer cells were treated with Apo2L/TRAIL. PTHrP overexpression increased MDA-MB-231 cells sensitivity to Apo2L/TRAIL-induced apoptosis. Interestingly, PTHrP sensitised MCF-7 cells to Apo2L/TRAIL-induced apoptosis. Apo2L/TRAIL-induced apoptosis in PTHrP overexpressing cells through the activation of caspase-10 resulting in caspase-9 activation and induction of apoptosis through the effector caspases, caspase-6 and -7. Studies with PTHrP peptides 1-34, 38-94, 67-86, 107-111, 106-139, 120-139 and 107-139 on MDA-MB-231 cells showed no effect on Apo2L/TRAIL-induced apoptosis, indicating that PTHrP’s action were unlikely to result from extracellular receptor signalling. PTHrP did not alter mRNA expression of Apo2L/TRAIL receptors; TRAIL-R1, TRAIL-R2, TRAIL-R3, TRAIL-R4 and OPG, however increased cell surface expression the death receptors TRAIL-R1 and TRAILR2 was observed. Antagonistic antibodies against the death receptors demonstrated that Apo2L/TRAIL preferentially bound to TRAIL-R2 to signal apoptosis. To identify potential genes involved in Apo2L/TRAIL resistance and/or sensitivity gene microarray experiments were performed comparing two breast cancer cell lines with differential sensitivities to Apo2L/TRAIL. CYP1B1 and CARD10 were identified to be differentially expressed. CARD10 was regulated by Apo2L/TRAIL in MDA-MB-231 cells, however there was no associated with PTHrP. CYP1B1 mRNA expression was decreased in PTHrP overexpressing cells. CYP1B1 mRNA expression was further down regulated by Apo2L/TRAIL in PTHrP overexpressing breast cancer cells. Overexpression studies of CYP1B1 in PTHrP overexpressing cells did not affect Apo2L/TRAIL-induced apoptosis, indicating that…

Subjects/Keywords: Cancer

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cheung, V. (2012). The role of PTHrP and Apo2L/TRAIL in breast cancer. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/37379

Chicago Manual of Style (16^th Edition):

Cheung, Vanessa. “The role of PTHrP and Apo2L/TRAIL in breast cancer.” 2012. Doctoral Dissertation, University of Melbourne. Accessed April 21, 2021. http://hdl.handle.net/11343/37379.

MLA Handbook (7^th Edition):

Cheung, Vanessa. “The role of PTHrP and Apo2L/TRAIL in breast cancer.” 2012. Web. 21 Apr 2021.

Vancouver:

Cheung V. The role of PTHrP and Apo2L/TRAIL in breast cancer. [Internet] [Doctoral dissertation]. University of Melbourne; 2012. [cited 2021 Apr 21]. Available from: http://hdl.handle.net/11343/37379.

Council of Science Editors:

Cheung V. The role of PTHrP and Apo2L/TRAIL in breast cancer. [Doctoral Dissertation]. University of Melbourne; 2012. Available from: http://hdl.handle.net/11343/37379

6. Samsonova, Anastasiia. Structural and functional insights into YB-1 and Lin28 interplay in mRNA regulation : Étude de la base structurale de l'interaction entre YB-1 et Lin28 et de ses conséquences fonctionnelles dans la régulation de la traduction.

Degree: Docteur es, Sciences de la vie et de la santé, 2020, université Paris-Saclay

URL: http://www.theses.fr/2020UPASL037

►

La régulation de l'ARNm dans les cellules humaines est l'un des mécanismes essentiels permettant aux cellules de s'adapter à un nouvel environnement et de répondre… (more)

▼

La régulation de l'ARNm dans les cellules humaines est l'un des mécanismes essentiels permettant aux cellules de s'adapter à un nouvel environnement et de répondre aux signaux entrants. En effet, il est bien plus efficace pour une cellule de réguler l'homéostasie protéique au niveau de la traduction des ARNm plutôt qu'en jouant sur la transcription ou les mécanismes de dégradation des protéines. Dans les mécanismes de régulation de la traduction de l'ARNm, les protéines de liaison à l'ARN (RBP) jouent un rôle clé.Au cours de ce travail de recherche, nous avons démontré que Lin28, une RBP humaine avec un domaine de choc froid peut interagir avec l'ARNm en coopération avec YB1, une protéine très abondante contenant aussi un domaine de choc froid, essentielle dans la constitution des mRNPs. L'interaction entre ces deux protéines est basée sur leur haute similitude de structure, et permet potentiellement à Lin28a de réguler la traduction nombreux mRNPs en utilisant YB-1 comme «badge d'entrée» au mRNP.Pour étudier l'interaction entre Lin28 et YB-1, différentes méthodes de biologie structurale et cellulaire ont été utilisées. D'abord, l'oligomérisation des domaines de choc froid de Lin28 et YB-1 en présence d'ARNm a été démontrée in vitro, et les résidus d'acides aminés impliqués dans ce processus ont été mis en évidence par spectroscopie RMN. Ensuite, la colocalisation dans le cytoplasme de Lin28 et YB-1 a été démontrée dans un contexte cellulaire. Finalement, nous avons révélé les conséquences fonctionnelles de cette interaction, par exemple dans le cadre de la prolifération et de la différenciation cellulaires. Ces résultats éclairent un nouveau rôle de Lin28 dans le développement et l'adaptation des cellules cancéreuses à leur environnement.

The mRNA regulation in human cells is one of the key mechanisms allowing the cells to adapt to a new environment and to respond to incoming signals. In terms of protein synthesis, the regulation of mRNA translation is a preferable process for cells compared to a more rigid mechanism of transcription or degradation. The RNA-binding proteins (RBPs) play a key role in the mRNA translation regulation.In the present work, we made an effort to demonstrate that a human RBP containing a cold shock domain, Lin28a, can act in cooperation with another cold shock protein YB-1, a core protein of mRNPs. The interplay between two cold shock proteins is based on their high structure similarity, that potentially gives Lin28 an opportunity to regulate the mRNA target translation in a general way using YB 1 as an “entry badge” to the mRNP.To demonstrate the interplay between Lin28 and YB 1, several methods of structural and cellular biology were used in the present study. The oligomerization of Lin28-CSD and YB-1-CSD upon RNA binding was shown in vitro, and the amino acid residues responsible for that were highlighted by NMR spectroscopy. Then, the colocalization of Lin28 and YB-1 was demonstrated in cell cytoplasm. Also, the protein interplay was shown to have functional consequences, e.g. for…

Advisors/Committee Members: Hamon, Loïc (thesis director), Pastre, David (thesis director).

Subjects/Keywords: Cancer

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APA (6^th Edition):

Samsonova, A. (2020). Structural and functional insights into YB-1 and Lin28 interplay in mRNA regulation : Étude de la base structurale de l'interaction entre YB-1 et Lin28 et de ses conséquences fonctionnelles dans la régulation de la traduction. (Doctoral Dissertation). université Paris-Saclay. Retrieved from http://www.theses.fr/2020UPASL037

Chicago Manual of Style (16^th Edition):

Samsonova, Anastasiia. “Structural and functional insights into YB-1 and Lin28 interplay in mRNA regulation : Étude de la base structurale de l'interaction entre YB-1 et Lin28 et de ses conséquences fonctionnelles dans la régulation de la traduction.” 2020. Doctoral Dissertation, université Paris-Saclay. Accessed April 21, 2021. http://www.theses.fr/2020UPASL037.

MLA Handbook (7^th Edition):

Samsonova, Anastasiia. “Structural and functional insights into YB-1 and Lin28 interplay in mRNA regulation : Étude de la base structurale de l'interaction entre YB-1 et Lin28 et de ses conséquences fonctionnelles dans la régulation de la traduction.” 2020. Web. 21 Apr 2021.

Vancouver:

Samsonova A. Structural and functional insights into YB-1 and Lin28 interplay in mRNA regulation : Étude de la base structurale de l'interaction entre YB-1 et Lin28 et de ses conséquences fonctionnelles dans la régulation de la traduction. [Internet] [Doctoral dissertation]. université Paris-Saclay; 2020. [cited 2021 Apr 21]. Available from: http://www.theses.fr/2020UPASL037.

Council of Science Editors:

Samsonova A. Structural and functional insights into YB-1 and Lin28 interplay in mRNA regulation : Étude de la base structurale de l'interaction entre YB-1 et Lin28 et de ses conséquences fonctionnelles dans la régulation de la traduction. [Doctoral Dissertation]. université Paris-Saclay; 2020. Available from: http://www.theses.fr/2020UPASL037

Oregon State University

7. Le, Uyen Minh. Improving the uptake and retention of gadolinium in tumors for potential gadolinium-neutron capture therapy: Integration of gemcitabine or localized irradiation into dsRNA therapy significantly enhanced the resultant anti-tumor activity.

Degree: PhD, Pharmacy, 2008, Oregon State University

URL: http://hdl.handle.net/1957/9442

► Cancer is one of the leading causes of death in the U.S., and new approaches to control cancer are constantly sought. This dissertation is comprised… (more)

▼ Cancer is one of the leading causes of death in the U.S., and new approaches to control cancer are constantly sought. This dissertation is comprised of two parts: (i) improving the uptake and retention of gadolinium in tumors for potential gadoliniumneutron capture therapy (Gd-NCT) and (ii) integration of gemcitabine or localized irradiation into dsRNA therapy significantly enhanced the resultant anti-tumor activity. One of the key factors for a successful Gd-NCT is to deliver and maintain a sufficient amount of Gd in tumor tissues (50-200 μg of Gd/g of wet tumor) during neutron irradiation, which has proven to be challenging to achieve. A gadolinium-encapsulated liposome (Gd-liposome) formulation was designed to address this need. The formulation was prepared by complexing diethylenetriaminepentaacetic acid (Gd- DTPA) with poly-L-lysine and then encapsulating the Gd-DTPA complexes intopegylated liposomes. The Gd-liposome formulation delivered as high as 159 μg of pure Gd per g of wet tumor tissue into model tumors in mice. A liposome-in-thermosensitive gel system that significantly extended the retention of the Gd in model tumors in mice was also designed. These Gd delivery systems may be used to deliver Gd into solid tumors for NCT and tumor imaging. Despite of the potent tumoricidal activity of polyinosine-cytosine (e.g. poly(I:C)), a synthetic dsRNA, in culture, its in vivo anti-tumor activity has proven to be limited. Gemcitabine, a chemotherapy agent, or localized x-ray radiation was successfully integrated into poly(I:C) therapy to improve the resultant anti-tumor activity in murine tumor models. Combining gemcitabine with poly(I:C) synergistically inhibited the growth of model tumors in mice and also generated a strong and durable tumorspecific immune response. Alternatively, integrating localized x-ray radiation into poly(I:C) therapy significantly delayed the tumor growth, but the combined activity was synergistic only in mice with highly immunogenic tumors, indicating that the T cell-mediated immunity was responsible for the synergy. The type I interferons (IFN- α/β) induced by poly(I:C) played a critical role in the resultant anti-tumor activity. These combination therapies may represent a promising approach to improve the clinical outcomes of poly(I:C) therapy. Advisors/Committee Members: CUI, ZHENGRONG (advisor), CHRISTENSEN, JOHN MARK (committee member).

Subjects/Keywords: cancer; Cancer – Radiotherapy

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APA (6^th Edition):

Le, U. M. (2008). Improving the uptake and retention of gadolinium in tumors for potential gadolinium-neutron capture therapy: Integration of gemcitabine or localized irradiation into dsRNA therapy significantly enhanced the resultant anti-tumor activity. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/9442

Chicago Manual of Style (16^th Edition):

Le, Uyen Minh. “Improving the uptake and retention of gadolinium in tumors for potential gadolinium-neutron capture therapy: Integration of gemcitabine or localized irradiation into dsRNA therapy significantly enhanced the resultant anti-tumor activity.” 2008. Doctoral Dissertation, Oregon State University. Accessed April 21, 2021. http://hdl.handle.net/1957/9442.

MLA Handbook (7^th Edition):

Le, Uyen Minh. “Improving the uptake and retention of gadolinium in tumors for potential gadolinium-neutron capture therapy: Integration of gemcitabine or localized irradiation into dsRNA therapy significantly enhanced the resultant anti-tumor activity.” 2008. Web. 21 Apr 2021.

Vancouver:

Le UM. Improving the uptake and retention of gadolinium in tumors for potential gadolinium-neutron capture therapy: Integration of gemcitabine or localized irradiation into dsRNA therapy significantly enhanced the resultant anti-tumor activity. [Internet] [Doctoral dissertation]. Oregon State University; 2008. [cited 2021 Apr 21]. Available from: http://hdl.handle.net/1957/9442.

Council of Science Editors:

Le UM. Improving the uptake and retention of gadolinium in tumors for potential gadolinium-neutron capture therapy: Integration of gemcitabine or localized irradiation into dsRNA therapy significantly enhanced the resultant anti-tumor activity. [Doctoral Dissertation]. Oregon State University; 2008. Available from: http://hdl.handle.net/1957/9442

8. Funsani, Peter. Morbidity and mortality trend analysis of cervical cancer in Zambia for the period 2007 to 2014: a case of Cancer Diseases Hospital.

Degree: 2016, University of Zimbabwe

URL: http://dspace.unza.zm/handle/123456789/4885

► In 2014 alone, over 3 million women aged ≥15 years were at risk of being diagnosed with cervical cancer in Zambia. Our study aimed at… (more)

Subjects/Keywords: Cervical Cancer; Cancer

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APA (6^th Edition):

Funsani, P. (2016). Morbidity and mortality trend analysis of cervical cancer in Zambia for the period 2007 to 2014: a case of Cancer Diseases Hospital. (Thesis). University of Zimbabwe. Retrieved from http://dspace.unza.zm/handle/123456789/4885

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Funsani, Peter. “Morbidity and mortality trend analysis of cervical cancer in Zambia for the period 2007 to 2014: a case of Cancer Diseases Hospital.” 2016. Thesis, University of Zimbabwe. Accessed April 21, 2021. http://dspace.unza.zm/handle/123456789/4885.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Funsani, Peter. “Morbidity and mortality trend analysis of cervical cancer in Zambia for the period 2007 to 2014: a case of Cancer Diseases Hospital.” 2016. Web. 21 Apr 2021.

Vancouver:

Funsani P. Morbidity and mortality trend analysis of cervical cancer in Zambia for the period 2007 to 2014: a case of Cancer Diseases Hospital. [Internet] [Thesis]. University of Zimbabwe; 2016. [cited 2021 Apr 21]. Available from: http://dspace.unza.zm/handle/123456789/4885.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Funsani P. Morbidity and mortality trend analysis of cervical cancer in Zambia for the period 2007 to 2014: a case of Cancer Diseases Hospital. [Thesis]. University of Zimbabwe; 2016. Available from: http://dspace.unza.zm/handle/123456789/4885

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of New Mexico

9. Smith, Randi L. Tumor Promoting Properties of Field Cancerized Fibroblasts in Cell Culture.

Degree: Biomedical Sciences Graduate Program, 2015, University of New Mexico

URL: https://digitalrepository.unm.edu/biom_etds/93

► Our recent studies have shown that Tumor Adjacent Histologically Normal (TAHN) breast tissue demonstrates many of the characteristics of breast tumors. For example, through immunohistochemical… (more)

Subjects/Keywords: Cancer; Breast Cancer

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APA (6^th Edition):

Smith, R. L. (2015). Tumor Promoting Properties of Field Cancerized Fibroblasts in Cell Culture. (Masters Thesis). University of New Mexico. Retrieved from https://digitalrepository.unm.edu/biom_etds/93

Chicago Manual of Style (16^th Edition):

Smith, Randi L. “Tumor Promoting Properties of Field Cancerized Fibroblasts in Cell Culture.” 2015. Masters Thesis, University of New Mexico. Accessed April 21, 2021. https://digitalrepository.unm.edu/biom_etds/93.

MLA Handbook (7^th Edition):

Smith, Randi L. “Tumor Promoting Properties of Field Cancerized Fibroblasts in Cell Culture.” 2015. Web. 21 Apr 2021.

Vancouver:

Smith RL. Tumor Promoting Properties of Field Cancerized Fibroblasts in Cell Culture. [Internet] [Masters thesis]. University of New Mexico; 2015. [cited 2021 Apr 21]. Available from: https://digitalrepository.unm.edu/biom_etds/93.

Council of Science Editors:

Smith RL. Tumor Promoting Properties of Field Cancerized Fibroblasts in Cell Culture. [Masters Thesis]. University of New Mexico; 2015. Available from: https://digitalrepository.unm.edu/biom_etds/93

Universiteit Utrecht

10. Yilmaz, V. Cancer Immunotherapy.

Degree: 2012, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/253742

► Cancer is the leading cause of death in economically developed countries and the conventional anti-cancer therapies fail to meet the criteria of an ideal, safe… (more)

Subjects/Keywords: Cancer; Immunotherapy; cancer immunology; cancer treatment

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APA (6^th Edition):

Yilmaz, V. (2012). Cancer Immunotherapy. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/253742

Chicago Manual of Style (16^th Edition):

Yilmaz, V. “Cancer Immunotherapy.” 2012. Masters Thesis, Universiteit Utrecht. Accessed April 21, 2021. http://dspace.library.uu.nl:8080/handle/1874/253742.

MLA Handbook (7^th Edition):

Yilmaz, V. “Cancer Immunotherapy.” 2012. Web. 21 Apr 2021.

Vancouver:

Yilmaz V. Cancer Immunotherapy. [Internet] [Masters thesis]. Universiteit Utrecht; 2012. [cited 2021 Apr 21]. Available from: http://dspace.library.uu.nl:8080/handle/1874/253742.

Council of Science Editors:

Yilmaz V. Cancer Immunotherapy. [Masters Thesis]. Universiteit Utrecht; 2012. Available from: http://dspace.library.uu.nl:8080/handle/1874/253742

University of Tasmania

11. Breaden, Katrina. Cancer and beyond : the question of survivorship.

Degree: 1995, University of Tasmania

URL: https://eprints.utas.edu.au/18855/1/whole_BreadenKatrina1995_thesis.pdf

► In Australia, as in many other countries in the Western world, the five year survival rate for persons diagnosed with cancer is now approaching 50… (more)

Subjects/Keywords: Cancer; Cancer; Cancer

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APA (6^th Edition):

Breaden, K. (1995). Cancer and beyond : the question of survivorship. (Thesis). University of Tasmania. Retrieved from https://eprints.utas.edu.au/18855/1/whole_BreadenKatrina1995_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Breaden, Katrina. “Cancer and beyond : the question of survivorship.” 1995. Thesis, University of Tasmania. Accessed April 21, 2021. https://eprints.utas.edu.au/18855/1/whole_BreadenKatrina1995_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Breaden, Katrina. “Cancer and beyond : the question of survivorship.” 1995. Web. 21 Apr 2021.

Vancouver:

Breaden K. Cancer and beyond : the question of survivorship. [Internet] [Thesis]. University of Tasmania; 1995. [cited 2021 Apr 21]. Available from: https://eprints.utas.edu.au/18855/1/whole_BreadenKatrina1995_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Breaden K. Cancer and beyond : the question of survivorship. [Thesis]. University of Tasmania; 1995. Available from: https://eprints.utas.edu.au/18855/1/whole_BreadenKatrina1995_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Tasmania

12. Jones, Catherine Cheryl. Two worlds in one : the lived experiences of seven people treated with autologous bone marrow/peripheral blood stem cell transplant.

Degree: 1996, University of Tasmania

URL: https://eprints.utas.edu.au/20373/1/whole_JonesCatherineCheryl1997_thesis.pdf

► Autologous bone marrow/peripheral blood stem cell transplant is one of the recent treatments to offer hope of a cure or prolonged remission for certain types… (more)

Subjects/Keywords: Cancer; Cancer; Cancer

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APA (6^th Edition):

Jones, C. C. (1996). Two worlds in one : the lived experiences of seven people treated with autologous bone marrow/peripheral blood stem cell transplant. (Thesis). University of Tasmania. Retrieved from https://eprints.utas.edu.au/20373/1/whole_JonesCatherineCheryl1997_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jones, Catherine Cheryl. “Two worlds in one : the lived experiences of seven people treated with autologous bone marrow/peripheral blood stem cell transplant.” 1996. Thesis, University of Tasmania. Accessed April 21, 2021. https://eprints.utas.edu.au/20373/1/whole_JonesCatherineCheryl1997_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jones, Catherine Cheryl. “Two worlds in one : the lived experiences of seven people treated with autologous bone marrow/peripheral blood stem cell transplant.” 1996. Web. 21 Apr 2021.

Vancouver:

Jones CC. Two worlds in one : the lived experiences of seven people treated with autologous bone marrow/peripheral blood stem cell transplant. [Internet] [Thesis]. University of Tasmania; 1996. [cited 2021 Apr 21]. Available from: https://eprints.utas.edu.au/20373/1/whole_JonesCatherineCheryl1997_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jones CC. Two worlds in one : the lived experiences of seven people treated with autologous bone marrow/peripheral blood stem cell transplant. [Thesis]. University of Tasmania; 1996. Available from: https://eprints.utas.edu.au/20373/1/whole_JonesCatherineCheryl1997_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Université de Grenoble

13. Sambourg, Laure. Décrypter les données omiques : importance du contrôle qualité. Application au cancer de l'ovaire : Decipher omics data, on the importance of quality control.

Degree: Docteur es, Modèles, méthodes et algorithmes en biologie, santé et environnement, 2013, Université de Grenoble

URL: http://www.theses.fr/2013GRENS027

►

Décrypter les données omiques : importance du contrôle qualité. Application au cancer de l’ovaire Au cours des dix dernières années, la taille et la complexité… (more)

▼

Décrypter les données omiques : importance du contrôle qualité. Application au cancer de l’ovaire Au cours des dix dernières années, la taille et la complexité des données biologiques ont littéralement explosé, et une attention particulière doit être portée au contrôle qualité. En effet, certaines données omiques (données génomiques et post-génomiques obtenues à haut débit) sont très incomplètes et/ou contiennent de nombreux biais et erreurs qu’il est facile de confondre avec de l’information biologiquement intéressante. Dans cette thèse, nous montrons que les interactions protéine-protéine issues de curation de la littérature et les interactions identifiées à haut débit sont beaucoup plus corrélées que ce qui est communément admis. Nous examinons l’interactome de la levure d’un point de vue original, en prenant en compte le degré d’étude des protéines par la communauté scientifique et nos résultats indiquent que cette corrélation s’estompe lorsqu’on se restreint aux protéines très étudiées. Ces observations nous permettent de proposer une méthode simple et fiable pour estimer la taille d’un interactome. Notre méthode conduit à une estimation d’au moins 37 600 interactions physiques directes chez S. cerevisiae, et montre que les évaluations précédentes sont trop faibles. Par ailleurs, nous étudions des données de séquençage nouvelle génération de l’ADN. Par une analyse des biais existant entre les short-reads alignés sur un brin ou sur l’autre du génome, nous mettons en évidence de nombreuses erreurs systématiques. De plus, nous observons de multiples positions présentant entre 20 et 40% de short-reads portant l’allèle variant : celles-ci ne peuvent pas être génotypées correctement. Nous proposons une méthode fiable pour appeler les génotypes à partir des données NGS qui permet de s’affranchir de ses difficultés. Enfin, nous appliquons cette méthode sur des données massives de séquençage d’exome de cellules saines et tumorales de 520 patientes atteintes du cancer de l’ovaire, produites par le consortium TCGA. Nous détectons en moyenne 30 632 variants germinaux par patiente. Parmi ces variants, nous identifions ceux les plus enclins à conférer un risque accru de développer la maladie : nous nous restreignons notamment aux variants induisant une perte de fonction de la protéine encodée et significativement plus présents chez les patientes que dans la population générale. Cela conduit à 44 SNVs par patiente en moyenne, répartis sur 334 gènes dans l’ensemble de la cohorte. Parmi ces 334 gènes, 42 ont été reportés comme impliqués dans la cancerogénèse, confirmant que la liste de candidats identifiés est fortement enrichie en gènes de susceptibilité au cancer de l’ovaire. En particulier, nos travaux confirment le rôle de suppresseur de tumeur de la protéine MAP3K8, très récemment proposée comme jouant un rôle clé dans d’autres cancers.

Deciphering omics data : on the importance of quality control. Application to ovarian cancer. Over the past 10 years, the size and complexity of biological data have exploded, and quality…

Advisors/Committee Members: Thierry-Mieg, Nicolas (thesis director).

Subjects/Keywords: NGS; Interactomique; Cancer; Cancer; Interactomic; Cancer; 610

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APA (6^th Edition):

Sambourg, L. (2013). Décrypter les données omiques : importance du contrôle qualité. Application au cancer de l'ovaire : Decipher omics data, on the importance of quality control. (Doctoral Dissertation). Université de Grenoble. Retrieved from http://www.theses.fr/2013GRENS027

Chicago Manual of Style (16^th Edition):

Sambourg, Laure. “Décrypter les données omiques : importance du contrôle qualité. Application au cancer de l'ovaire : Decipher omics data, on the importance of quality control.” 2013. Doctoral Dissertation, Université de Grenoble. Accessed April 21, 2021. http://www.theses.fr/2013GRENS027.

MLA Handbook (7^th Edition):

Sambourg, Laure. “Décrypter les données omiques : importance du contrôle qualité. Application au cancer de l'ovaire : Decipher omics data, on the importance of quality control.” 2013. Web. 21 Apr 2021.

Vancouver:

Sambourg L. Décrypter les données omiques : importance du contrôle qualité. Application au cancer de l'ovaire : Decipher omics data, on the importance of quality control. [Internet] [Doctoral dissertation]. Université de Grenoble; 2013. [cited 2021 Apr 21]. Available from: http://www.theses.fr/2013GRENS027.

Council of Science Editors:

Sambourg L. Décrypter les données omiques : importance du contrôle qualité. Application au cancer de l'ovaire : Decipher omics data, on the importance of quality control. [Doctoral Dissertation]. Université de Grenoble; 2013. Available from: http://www.theses.fr/2013GRENS027

Cornell University

14. Sullivan, Kelly. Studies Of The Molecular Mechanisms Underlying Cancer Stem Cells And The Transformed Metabolic Phenotype.

Degree: PhD, Biochemistry, 2015, Cornell University

URL: http://hdl.handle.net/1813/41119

► Intense research throughout recent decades has significantly expanded our knowledge of the complexities that make cancer a highly diverse and therapeutically challenging disease. Recently, cancer… (more)

▼ Intense research throughout recent decades has significantly expanded our knowledge of the complexities that make cancer a highly diverse and therapeutically challenging disease. Recently, cancer stem cells (CSCs) and de-regulated cellular metabolism have become appreciated for their crucial roles in the development, growth, and therapy resistance of tumors, and are now being pursued as therapeutic targets for the treatment of cancer. To better understand how these oncogenic events contribute to tumor malignancy, I carried out a mechanistic analysis of the CSC marker aldehyde dehydrogenase 1A3 (ALDH1A3) and the GTP-binding protein/crosslinking enzyme tissue transglutaminase (tTG), two proteins suspected to have key roles in tumor initiation and the development of the malignant state, in glioma stem cells (GSCs). Additionally, I examined the contributions of two isoforms of glutaminase (GLS), given the critical role of elevated glutamine metabolism in maintaining the transformed state. In delineating the role of ALDH1A3 in GSCs, I discovered that it is an important regulator of gene expression through the production of retinoic acid (RA). Specifically, I demonstrated that the expression of tTG is induced downstream of ALDH1A3 via RA in highly aggressive GSCs. Furthermore, targeting tTG results in a dramatic reduction in the self-renewal of these cells, suggesting that it may be a viable therapeutic target in ALDH1A3 + GSCs. Finally, I showed that combination therapies including a tTG inhibitor and radiation or chemotherapy are cytotoxic, indicating that tTG inhibitors enhance the effects of standard glioma therapies. Work described in this thesis has also been directed toward understanding the roles of different splice variants of the metabolic enzyme GLS in cancer cell growth. An important question in the field has concerned whether the two known GLS splice variants, glutaminase C (GAC) and kidney-type glutaminase (KGA), have redundant or opposing functions. This becomes especially relevant when considering the importance of targeting one or both of these enzymes when designing strategies to inhibit the metabolic reprogramming of cancer cells. Here, I show that although KGA is expressed at low levels in cancer cells relative to GAC, these isoforms are functionally redundant in their abilities to support the transformed metabolic phenotype. Advisors/Committee Members: Cerione,Richard A (chair), Emr,Scott David (committee member), Linder,Maurine E. (committee member).

Subjects/Keywords: Cancer stem cells; Cancer metabolism; Cancer therapies

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sullivan, K. (2015). Studies Of The Molecular Mechanisms Underlying Cancer Stem Cells And The Transformed Metabolic Phenotype. (Doctoral Dissertation). Cornell University. Retrieved from http://hdl.handle.net/1813/41119

Chicago Manual of Style (16^th Edition):

Sullivan, Kelly. “Studies Of The Molecular Mechanisms Underlying Cancer Stem Cells And The Transformed Metabolic Phenotype.” 2015. Doctoral Dissertation, Cornell University. Accessed April 21, 2021. http://hdl.handle.net/1813/41119.

MLA Handbook (7^th Edition):

Sullivan, Kelly. “Studies Of The Molecular Mechanisms Underlying Cancer Stem Cells And The Transformed Metabolic Phenotype.” 2015. Web. 21 Apr 2021.

Vancouver:

Sullivan K. Studies Of The Molecular Mechanisms Underlying Cancer Stem Cells And The Transformed Metabolic Phenotype. [Internet] [Doctoral dissertation]. Cornell University; 2015. [cited 2021 Apr 21]. Available from: http://hdl.handle.net/1813/41119.

Council of Science Editors:

Sullivan K. Studies Of The Molecular Mechanisms Underlying Cancer Stem Cells And The Transformed Metabolic Phenotype. [Doctoral Dissertation]. Cornell University; 2015. Available from: http://hdl.handle.net/1813/41119

15. Elango, J Kalavathy. Risk profile of oral cancers and strategies to improve awareness and early detection.

Degree: 2009, Amrita Vishwa Vidyapeetham (University)

URL: http://shodhganga.inflibnet.ac.in/handle/10603/2363

►

Fundamentals of implementing any cancer control programs are the understanding of the burden of the disease in the community (incidence trends), risk factor profile and… (more)

Subjects/Keywords: Oral cancer; Oncology; Cancer prevention; Cancer treatment

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APA (6^th Edition):

Elango, J. K. (2009). Risk profile of oral cancers and strategies to improve awareness and early detection. (Thesis). Amrita Vishwa Vidyapeetham (University). Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/2363

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Elango, J Kalavathy. “Risk profile of oral cancers and strategies to improve awareness and early detection.” 2009. Thesis, Amrita Vishwa Vidyapeetham (University). Accessed April 21, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/2363.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Elango, J Kalavathy. “Risk profile of oral cancers and strategies to improve awareness and early detection.” 2009. Web. 21 Apr 2021.

Vancouver:

Elango JK. Risk profile of oral cancers and strategies to improve awareness and early detection. [Internet] [Thesis]. Amrita Vishwa Vidyapeetham (University); 2009. [cited 2021 Apr 21]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/2363.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Elango JK. Risk profile of oral cancers and strategies to improve awareness and early detection. [Thesis]. Amrita Vishwa Vidyapeetham (University); 2009. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/2363

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

McMaster University

16. Yan, Judy. Characterizing prostate cancer stem-like cells and their contribution to prostate cancer tumorigenesis.

Degree: PhD, 2014, McMaster University

URL: http://hdl.handle.net/11375/16285

►

On average, 65 Canadian men will be diagnosed with prostate cancer (PC) every day, making it the most common male cancer in Canada. Despite the… (more)

▼

On average, 65 Canadian men will be diagnosed with prostate cancer (PC) every day, making it the most common male cancer in Canada. Despite the prevalence, the etiology of PC is unknown. Evidence nonetheless supports the role of prostate cancer stem cells (PCSCs) in PC initiation and metastasis. In spite of almost a decade worth of research on PCSCs our knowledge on their biology remains fragmented. By taking advantage of the availability of DU145 cell-derived PCSCs in our laboratory, this thesis research focuses on investigating the unique properties of PCSCs and their function in promoting PC tumorigenesis. We identified two PCSC-specific proteins, ALDH3A1 and CNTN1. In mouse models of xenograft tumors, ALDH3A1 was expressed at higher levels in PCSC-derived tumors than in DU145 non-PCSC-produced tumors and in lung metastases than local tumors. In clinical settings, elevation of ALDH3A1expression was observed from normal prostate tissues to carcinomas and from local PCs to the paired lymph node metastases. Additionally, ALDH3A1 was clearly detected in bone metastases. Similar to ALDH3A1, CNTN1 expression associates with PC progression and biochemical recurrence following radical prostatectomy. The clear presence of CNTN1 in lymph node and bone metastases was also demonstrated. Furthermore, CNTN1 expression promoted PC metastasis to the lungs and tumor initiation in NOD/SCID mice. Mechanistically, CNTN1 increased AKT activation and reduced E-cadherin expression. Collectively, our research revealed important roles of both PCSC proteins in promoting PC tumorigenesis and progression. PC develops chemotherapy resistance in which PCSCs play a major role. In supporting this knowledge, we demonstrated that PCSCs are innately more resistant to the chemotherapeutic drugs, etoposide and docetaxel and that this resistance was in part attributable to their enhanced DNA damage response. Taken together, the findings of this thesis advances our knowledge on two specific PCSC markers and their association with prostate cancer progression and metastasis. As well as to the mechanism whereby PCSCs promote resistance to chemotherapeutic drugs.

Thesis

Doctor of Philosophy (PhD)

Advisors/Committee Members: Tang, Damu, Medical Sciences.

Subjects/Keywords: Cancer; Cancer stem cells; Prostate Cancer

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Yan, J. (2014). Characterizing prostate cancer stem-like cells and their contribution to prostate cancer tumorigenesis. (Doctoral Dissertation). McMaster University. Retrieved from http://hdl.handle.net/11375/16285

Chicago Manual of Style (16^th Edition):

Yan, Judy. “Characterizing prostate cancer stem-like cells and their contribution to prostate cancer tumorigenesis.” 2014. Doctoral Dissertation, McMaster University. Accessed April 21, 2021. http://hdl.handle.net/11375/16285.

MLA Handbook (7^th Edition):

Yan, Judy. “Characterizing prostate cancer stem-like cells and their contribution to prostate cancer tumorigenesis.” 2014. Web. 21 Apr 2021.

Vancouver:

Yan J. Characterizing prostate cancer stem-like cells and their contribution to prostate cancer tumorigenesis. [Internet] [Doctoral dissertation]. McMaster University; 2014. [cited 2021 Apr 21]. Available from: http://hdl.handle.net/11375/16285.

Council of Science Editors:

Yan J. Characterizing prostate cancer stem-like cells and their contribution to prostate cancer tumorigenesis. [Doctoral Dissertation]. McMaster University; 2014. Available from: http://hdl.handle.net/11375/16285

17. Little, Nicole S. Investigating the co-evolution of tumor antigens and the anti-tumor immune response.

Degree: Department of Biochemistry and Microbiology, 2017, University of Victoria

URL: https://dspace.library.uvic.ca//handle/1828/8503

► Background: High-grade serous carcinoma (HGSC) can exhibit high intratumoral heterogeneity (ITH). Despite a strong association between tumor-infiltrating lymphocytes (TIL) and survival in HGSC, ITH may… (more)

▼ Background: High-grade serous carcinoma (HGSC) can exhibit high intratumoral heterogeneity (ITH). Despite a strong association between tumor-infiltrating lymphocytes (TIL) and survival in HGSC, ITH may have profound impacts on the anti-tumor T cell response. Yet, it is unknown how anti-tumor T cell responses contend with ITH over time in HGSC. Previous studies in melanoma and HGSC both showed tumor-reactive T cell clones emerge over time with their cognate tumor-antigens. Therefore, I hypothesized patients would share a common mechanism of T cell evolution to respond to ITH in HGSC. If so, I expect to see similar patterns of tumor recognition between primary and recurrent disease. Methods: Tumor-associated lymphocytes (TAL) were expanded from primary and recurrent ascites samples using high-dose IL-2 and a rapid-expansion protocol (REP). Following expansion, TAL were assessed for recognition of autologous tumor by IFN-γ ELISPOT and flow cytometry for CD137. CD137+ tumor-reactive TAL were FACS-purified and the tumor-reactive T cell repertoire was profiled by deep sequencing of TCRβ chains (TCRseq). Tumor-reactive TCR clonotypes were compared between primary and recurrent disease to elucidate differences in tumor-reactive populations over time in HGSC. Results: Patient TAL recognized tumor in two out of three cases. In patient IROC 060, the tumor became more immunogenic between primary and recurrent disease, which may reflect expression of new antigens and/or loss of an immunosuppressive phenotype. In patient IROC 106, the tumor remained immunogenic between primary and recurrent disease, which may reflect maintenance of stable antigen expression and an immune-sensitive phenotype. Patient IROC 034 did not exhibit any tumor-reactivity, suggesting tumor-reactivity is not ubiquitous in HGSC. FACS-purification of CD137+ T cells followed by TCRseq was successfully performed on T cell populations of both high- and low-abundance, suggesting TCRseq can be performed on populations containing very few T cells. TCRseq results that profiled the clonal repertoire of tumor-reactive TAL from primary and recurrent disease in two patients, IROC 060 and IROC 106, showed both patients had evidence of T cell loss and T cell emergence between primary and recurrent disease. Further, IROC 106 had evidence of T cell clones that were maintained between primary and recurrent disease. Conclusions: Anti-tumor T cell responses from ascites are both diverse between patients and dynamic within a patient, suggesting various mechanisms of T cell evolution to contend with ITH in HGSC. I developed a pipeline for the identification of tumor-reactive TCR sequences without the need for a priori knowledge of specific antigens. Additionally, this pipeline is feasible for very low-abundance samples, such as tumor-reactive T cells. Significance: This study provides early insights into how TAL contend with ITH in HGSC. Ultimately, these results will inform the design of adoptive T cell therapy for recurrent HGSC. Advisors/Committee Members: Nelson, Brad H. (supervisor).

Subjects/Keywords: Cancer; Cancer Immunotherapy; Ovarian Cancer; Immunology; Immunotherapy

10 more images…

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APA (6^th Edition):

Little, N. S. (2017). Investigating the co-evolution of tumor antigens and the anti-tumor immune response. (Masters Thesis). University of Victoria. Retrieved from https://dspace.library.uvic.ca//handle/1828/8503

Chicago Manual of Style (16^th Edition):

Little, Nicole S. “Investigating the co-evolution of tumor antigens and the anti-tumor immune response.” 2017. Masters Thesis, University of Victoria. Accessed April 21, 2021. https://dspace.library.uvic.ca//handle/1828/8503.

MLA Handbook (7^th Edition):

Little, Nicole S. “Investigating the co-evolution of tumor antigens and the anti-tumor immune response.” 2017. Web. 21 Apr 2021.

Vancouver:

Little NS. Investigating the co-evolution of tumor antigens and the anti-tumor immune response. [Internet] [Masters thesis]. University of Victoria; 2017. [cited 2021 Apr 21]. Available from: https://dspace.library.uvic.ca//handle/1828/8503.

Council of Science Editors:

Little NS. Investigating the co-evolution of tumor antigens and the anti-tumor immune response. [Masters Thesis]. University of Victoria; 2017. Available from: https://dspace.library.uvic.ca//handle/1828/8503

University of the Western Cape

18. Fadaka, Adewale Oluwaseun. MicroRNAs as predictive biomarkers for diagnosis and prognosis of colorectal cancer using in silico approaches .

Degree: 2019, University of the Western Cape

URL: http://hdl.handle.net/11394/7161

► Colorectal cancer (CRC) is referred to as cancers that arise in the colon or rectum. Rectal cancer is most often defined as cancers originating within… (more)

Subjects/Keywords: Colorectal cancer; Cancer biomarkers; Cancer; Early detection

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APA (6^th Edition):

Fadaka, A. O. (2019). MicroRNAs as predictive biomarkers for diagnosis and prognosis of colorectal cancer using in silico approaches . (Thesis). University of the Western Cape. Retrieved from http://hdl.handle.net/11394/7161

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Fadaka, Adewale Oluwaseun. “MicroRNAs as predictive biomarkers for diagnosis and prognosis of colorectal cancer using in silico approaches .” 2019. Thesis, University of the Western Cape. Accessed April 21, 2021. http://hdl.handle.net/11394/7161.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Fadaka, Adewale Oluwaseun. “MicroRNAs as predictive biomarkers for diagnosis and prognosis of colorectal cancer using in silico approaches .” 2019. Web. 21 Apr 2021.

Vancouver:

Fadaka AO. MicroRNAs as predictive biomarkers for diagnosis and prognosis of colorectal cancer using in silico approaches . [Internet] [Thesis]. University of the Western Cape; 2019. [cited 2021 Apr 21]. Available from: http://hdl.handle.net/11394/7161.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Fadaka AO. MicroRNAs as predictive biomarkers for diagnosis and prognosis of colorectal cancer using in silico approaches . [Thesis]. University of the Western Cape; 2019. Available from: http://hdl.handle.net/11394/7161

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Nelson Mandela Metropolitan University

19. Van Vuuren, Larry Peter. Identification of membrane biomakers for colorectal cancer using an in-solico and molecular approach.

Degree: Faculty of Science, 2014, Nelson Mandela Metropolitan University

URL: http://hdl.handle.net/10948/47970

► The aim of this study was to identify membrane biomarkers for colorectal cancer using an insilico and molecular approach. Colorectal cancer (CRC) globally accounts for… (more)

▼ The aim of this study was to identify membrane biomarkers for colorectal cancer using an insilico and molecular approach. Colorectal cancer (CRC) globally accounts for more than half a million deaths. In South Africa alone, approximately one in 97 men is at risk of getting CRC; and for women, it is one in 162. Novel and non-invasive diagnostic tools, such as biomarkers, are needed for early CRC detection. In order to reduce the fatality rate in this disease, Biomarkers are used as indicators of a biological state; and they are measurable in biological media. They can be used to distinguish between a diseased state and a normal state, thus aiding diagnostics, response to specific therapies, and screening for an early diagnosis. A gene list of potential CRC biomarkers was generated by mining two gene databases, namely: Oncomine and Gene Expression Atlas. A total of 44 candidate genes were identified, based on their location on the cell surface, using the Database for Annotation, Visualisation and Integrated Discovery. These 44 genes were then subjected to an in-depth literature mining. The literature search parameters in PubMed, PubMed Central, Google Scholar and Science direct revealed publications showing that 23 genes were validated, while 21 genes were not validated. Nineteen genes were selected for gene validation in human colorectal cancer and healthy tissue of twelve patients. Total RNA was extracted from 12 colorectal cancer and 12 healthy tissue samples. The RNA was then quantified and reverse-transcribed into cDNA for gene expression analysis. The qPCR running conditions were optimized, by running a melting curve, in order to determine the optimum annealing temperatures. Primarily melt curves were run for nineteen of these twenty-one genes. Melt-curve analysis showed that nine genes were poor candidates for further validation studies; and therefore, only ten genes, namely: AGTRAP, ANKRD46, BACE2, CFB, CIAO1, NOMO3, PTDSS1, SLC5A6, TNFRSF12A and ZDHHC9 were validated by qPCR in human resected colorectal carcinoma and the normal tissues of twelve patients. The qPCR results showed that ZDHHC9 and the SLC5A6 genes were the only two statistically significant ones; and they were found to be down-regulated in human colorectal cancer vs healthy tissue samples.

Subjects/Keywords: Cancer – Research; Colon (Anatomy) – Cancer; Rectum – Cancer

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APA (6^th Edition):

Van Vuuren, L. P. (2014). Identification of membrane biomakers for colorectal cancer using an in-solico and molecular approach. (Thesis). Nelson Mandela Metropolitan University. Retrieved from http://hdl.handle.net/10948/47970

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Van Vuuren, Larry Peter. “Identification of membrane biomakers for colorectal cancer using an in-solico and molecular approach.” 2014. Thesis, Nelson Mandela Metropolitan University. Accessed April 21, 2021. http://hdl.handle.net/10948/47970.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Van Vuuren, Larry Peter. “Identification of membrane biomakers for colorectal cancer using an in-solico and molecular approach.” 2014. Web. 21 Apr 2021.

Vancouver:

Van Vuuren LP. Identification of membrane biomakers for colorectal cancer using an in-solico and molecular approach. [Internet] [Thesis]. Nelson Mandela Metropolitan University; 2014. [cited 2021 Apr 21]. Available from: http://hdl.handle.net/10948/47970.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Van Vuuren LP. Identification of membrane biomakers for colorectal cancer using an in-solico and molecular approach. [Thesis]. Nelson Mandela Metropolitan University; 2014. Available from: http://hdl.handle.net/10948/47970

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Rutgers University

20. Chen, Jayson Xiao-Chen, 1982-. Cancer preventive effects of tocopherols in dietary carcinogen-induced colon and prostate carcinogenesis models.

Degree: PhD, Toxicology, 2016, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/51247/

►

Colorectal and prostate cancers are leading causes of morbidity and mortality in the United States and worldwide. While immense progress has been made in reducing… (more)

▼

Colorectal and prostate cancers are leading causes of morbidity and mortality in the United States and worldwide. While immense progress has been made in reducing incidence and death of these cancers in the past few decades, they remain major public health issues, highlighting the need for better understanding, prevention and intervention of these diseases. One major strategy to address these issues is research into more relevant animal cancer models and potent chemopreventive agents. The purpose of this dissertation research was to characterize a novel colon carcinogenesis model induced by the meat-derived carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), with colitis from Dextran Sodium Sulfate (DSS) and determine the effects of different tocopherol forms of vitamin E on the colon carcinogenesis model as well as a PhIP-induced prostate carcinogenesis model. The rapid induction of PhIP/DSS-induced colon carcinogenesis in the CYP1A-humanized mice was determined to be caused by active Ctnnb1/Î²-catenin mutations in residual epithelial cells, which when promoted by colitis, developed into precancerous lesion, high-grade dysplasia, and finally adenocarcinoma. These features resembled human colitis-associated colon cancer. In the PhIP/DSS-induced colon carcinogenesis model, dietary supplementation with d-T and g-T, but not a-T, significantly attenuated colon tumor formation and inhibited oxidative and nitrosative stress as well as pro-inflammatory markers. Additional studies indicate the potent inhibitory effects of d-T and g-T was mainly due to protection against early cellular and DNA damage caused by the PhIP carcinogen. In the PhIP-induced prostate carcinogenesis model, dietary supplementation with g-TmT and d-T effectively reduced the formation and severity of mouse PIN lesions as well as p-Akt expression, whereas g-T and a-T were less effective. Further studies suggest the chemopreventive effects of the tocopherols involved the reduction in cellular oxidative and nitrosative stress and inhibition of the PI3K/Akt signaling pathway that regulate cell survival and proliferation. Together, the findings from this research demonstrate the relevance of PhIP dietary carcinogen-induced and DSS colitis-promoted colon carcinogenesis model and the superior cancer preventive activities of d-T and g-T compared to the classic a-T.

Advisors/Committee Members: yang, chung s (chair), Reuhl, Kenneth (internal member), Zarbl, Helmut (internal member), Suh, Nanjoo (internal member), Verzi, Michael (outside member).

Subjects/Keywords: Cancer – Prevention; Colon (Anatomy) – Cancer; Prostate – Cancer

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APA (6^th Edition):

Chen, Jayson Xiao-Chen, 1. (2016). Cancer preventive effects of tocopherols in dietary carcinogen-induced colon and prostate carcinogenesis models. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/51247/

Chicago Manual of Style (16^th Edition):

Chen, Jayson Xiao-Chen, 1982-. “Cancer preventive effects of tocopherols in dietary carcinogen-induced colon and prostate carcinogenesis models.” 2016. Doctoral Dissertation, Rutgers University. Accessed April 21, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/51247/.

MLA Handbook (7^th Edition):

Chen, Jayson Xiao-Chen, 1982-. “Cancer preventive effects of tocopherols in dietary carcinogen-induced colon and prostate carcinogenesis models.” 2016. Web. 21 Apr 2021.

Vancouver:

Chen, Jayson Xiao-Chen 1. Cancer preventive effects of tocopherols in dietary carcinogen-induced colon and prostate carcinogenesis models. [Internet] [Doctoral dissertation]. Rutgers University; 2016. [cited 2021 Apr 21]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/51247/.

Council of Science Editors:

Chen, Jayson Xiao-Chen 1. Cancer preventive effects of tocopherols in dietary carcinogen-induced colon and prostate carcinogenesis models. [Doctoral Dissertation]. Rutgers University; 2016. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/51247/

Rutgers University

21. Hemler, Jennifer R., 1972-. Life with, after, or beyond cancer: breast cancer survivorship and the new normal.

Degree: PhD, Sociology, 2015, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/48509/

►

I examine how women “move on,” or are unable to, after a diagnosis of breast cancer. I interviewed 80 survivors of various types and stages… (more)

▼

I examine how women “move on,” or are unable to, after a diagnosis of breast cancer. I interviewed 80 survivors of various types and stages of breast cancer to explore the relationship between how breast cancer survivors think about cancer and how they manage the daily consequences of this disease, including its effects on identity. My main objective was to examine the cognitive strategies and social practices survivors employ for living with (a history of having had) cancer. Cancer experience is undoubtedly shaped by factors like disease stage and type, treatments received, time since diagnosis and treatment, age, and social location. But many of my participants, across categories, described bracketing some aspects of their experience while holding onto a certain degree of ontological insecurity as they redefined their lives after, with, or beyond cancer. Drawing on ontological insecurity enabled them to remain attuned to their selves: they used cancer to help them redraw boundaries in their lives and focus attention on their selves in ways they were not doing previously. While self-regulatory health practices, feminist ideologies/the women’s health movement, and environmental awareness overlap in breast cancer survivorship to produce activated patients and actualized subjectivities, my participants also discussed how the existential and medical uncertainties of their experiences led them to create new spaces for meaning in their lives. However, while many of my participants wanted to use cancer as a catalyst for self-growth or change across life domains, certainly not all of them were able to do so. Survivorship programs are critical in this regard. They can help survivors harness the uncertainty they feel instead of allowing it to become paralyzing or debilitating. Many survivors need help framing ontological insecurity as a resource to employ, not something to move beyond; but, moreover, they need spaces in which they can acknowledge these uncertainties as part of their new realities.

Advisors/Committee Members: Cerulo, Karen A (chair), Carr, Deborah (internal member), Horwitz, Allan (internal member), Almeling, Rene (outside member).

Subjects/Keywords: Breast – Cancer; Breast cancer patients; Cancer – Patients

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APA (6^th Edition):

Hemler, Jennifer R., 1. (2015). Life with, after, or beyond cancer: breast cancer survivorship and the new normal. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/48509/

Chicago Manual of Style (16^th Edition):

Hemler, Jennifer R., 1972-. “Life with, after, or beyond cancer: breast cancer survivorship and the new normal.” 2015. Doctoral Dissertation, Rutgers University. Accessed April 21, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/48509/.

MLA Handbook (7^th Edition):

Hemler, Jennifer R., 1972-. “Life with, after, or beyond cancer: breast cancer survivorship and the new normal.” 2015. Web. 21 Apr 2021.

Vancouver:

Hemler, Jennifer R. 1. Life with, after, or beyond cancer: breast cancer survivorship and the new normal. [Internet] [Doctoral dissertation]. Rutgers University; 2015. [cited 2021 Apr 21]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/48509/.

Council of Science Editors:

Hemler, Jennifer R. 1. Life with, after, or beyond cancer: breast cancer survivorship and the new normal. [Doctoral Dissertation]. Rutgers University; 2015. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/48509/

University of Helsinki

22. Gylfe, Alexandra. New insights into the genetic basis of colorectal cancer.

Degree: Haartman Institute, Faculty of Medicine, Department of Medical Genetics; Research Programs Unit, Genome-Scale Biology Research Program, 2014, University of Helsinki

URL: http://hdl.handle.net/10138/44717

► Colorectal cancer (CRC) is the third most common cancer, and the second most common cause of cancer mortality. The aim of this thesis work was… (more)

▼ Colorectal cancer (CRC) is the third most common cancer, and the second most common cause of cancer mortality. The aim of this thesis work was to gain novel insight into the molecular mechanisms behind CRC predisposition, as well as tumor progression and development. Microsatellite instability (MSI) arises due to a defective mismatch repair system and is characteristic for a subset of all CRCs. Here, we aimed to identify novel MSI target genes with potential oncogenic effects. We characterized all genes overexpressed in MSI CRCs and predicted to escape nonsense-mediated decay when mutated. The mitotic checkpoint kinase TTK was identified with protein-elongating mutations in 59% of MSI CRCs. TTK has an essential role in spindle assembly checkpoint (SAC) signaling, however, the mutated protein did not show SAC weakening. While no evidence of oncogenic mechanisms was observed, the high mutation frequency of TTK argues for biological significance. In another screening effort on MSI CRCs, we sought to identify novel oncogenes with activating hotspot mutations. The exomes of 25 tumor and respective healthy colon tissues were sequenced. A total of 15 candidate oncogenes with hotspot mutations were identified. Three genes, ZBTB2, PSRC1 and RANBP2, displayed hotspot mutations also in the validation set of 86 MSI CRCs. Interestingly, the CRC-associated mutant form of ZBTB2 increased cell proliferation. Additional work is needed to further clarify the role of the identified somatic mutations in CRC tumorigenesis. The candidate oncogenes identified in this thesis work might be used to develop personalized tumor profiling and therapy. Inherited susceptibility is estimated to be involved in approximately one-third of all CRCs. However, the great majority of inherited CRC susceptibility remains still molecularly unexplained. A recent systematic sequencing study on CRC reported a set of somatically mutated genes, termed candidate cancer (CAN) genes. We examined the mutational profiles of 15 top-ranked CAN genes for somatic mutations as well as for germline variants in 45 familial CRC cases. In our tumor set, six of the CAN genes were somatically mutated. In germline, three private missense variants were identified in CSMD3, EPHB6 and c10orf137. In another effort, we exome sequenced 96 independent cases with familial CRC. We identified 11 novel candidate CRC susceptibility genes with rare putative LoF variants. Seven loss-of-heterozygosity events, involving four genes, were observed in the data. In each occasion, the losses targeted the wild-type allele (P=0.0078), providing further support that true culprits are among the eleven genes. This study provides an interesting set of candidate predisposing genes, which might explain a subset of common familial CRC. The identified germline variants need to be validated in larger sample sets to provide firm evidence for disease predisposition. Additional work is also needed to characterize the detailed functional and clinical relevance of the identified candidate CRC predisposing genes.…

Subjects/Keywords: cancer Genetics; cancer Genetics

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APA (6^th Edition):

Gylfe, A. (2014). New insights into the genetic basis of colorectal cancer. (Doctoral Dissertation). University of Helsinki. Retrieved from http://hdl.handle.net/10138/44717

Chicago Manual of Style (16^th Edition):

Gylfe, Alexandra. “New insights into the genetic basis of colorectal cancer.” 2014. Doctoral Dissertation, University of Helsinki. Accessed April 21, 2021. http://hdl.handle.net/10138/44717.

MLA Handbook (7^th Edition):

Gylfe, Alexandra. “New insights into the genetic basis of colorectal cancer.” 2014. Web. 21 Apr 2021.

Vancouver:

Gylfe A. New insights into the genetic basis of colorectal cancer. [Internet] [Doctoral dissertation]. University of Helsinki; 2014. [cited 2021 Apr 21]. Available from: http://hdl.handle.net/10138/44717.

Council of Science Editors:

Gylfe A. New insights into the genetic basis of colorectal cancer. [Doctoral Dissertation]. University of Helsinki; 2014. Available from: http://hdl.handle.net/10138/44717

University of Helsinki

23. Mpindi, John Patrick. Bioinformatic tools for analysis, mining and modelling large-scale gene expression and drug testing datasets : Bioinformatic tools for analyzing large-scale biomedical datasets.

Degree: Institute of Biomedicine, Faculty of Medicine; Institute for Molecular Medicine Finland FIMM, 2016, University of Helsinki

URL: http://hdl.handle.net/10138/160326

► Bioinformatic tools applied to large-scale genomic and gene expression datasets have helped in developing our understanding of the molecular basis of cancer. They have also… (more)

▼ Bioinformatic tools applied to large-scale genomic and gene expression datasets have helped in developing our understanding of the molecular basis of cancer. They have also become an important component of the drug discovery and development process, and potentially of personalized medicine for the future. Bioinformatic studies are now benefiting from the wealth of large datasets generated in laboratories through the use of new high-throughput technologies and their massive public repositories of data. As of October 2015,the GEO database (www.ncbi.nih.gov/geo/) alone comprised 1,597,783 samples across 15,040 platforms, and it is being updated on a daily basis. It is becoming evident that biological data are accumulating faster than the capacity of the scientific community to analyse, integrate and mine the data, as well as to create knowledge, understanding, and insights from the data. Thus, there is a growing need for better bioinformatic tools for analyzing, mining and modelling both local and global datasets. Many data analysis projects have called for the assembly of specialized data analysis tasks and pipelines. In the future, bioinformaticians need to be involved in both methods development and in applied bioinformatics. Methods development refers to developing new algorithms, while applied bioinformatics involves putting together existing tools/pipelines in a creative way to perform an analysis task. Bioinformatics is complicated due to the heterogeneous nature of the data, varying experimental settings, small sample sizes with little replication and the existence of many distributions in the data. There is also no uniformly accepted method for large-scale integrated data analysis. The aim of this study was to develop bioinformatic and statistical tools to perform an integrated analysis of large-scale microarray gene expression, high-throughput RNAi screening and drug testing data, as well as to demonstrate the applicability of these approaches in cancer research, drug target discovery and drug testing. First,the gene tissue index (GTI) outlier analysis method was developed to identify cancer outlier genes from large-scale microarray datasets. The need to identify genes ( outlier genes ) highly expressed in a subgroup of samples rendered some of the traditional differential expression analysis methods inadequate. The GTI method enabled the analysis and mining of outlier expression profiles from heterogeneous large-scale microarray datasets that usually contain a variable number of samples for each gene being compared. Using real and simulation study datasets, the performance of the GTI method was evaluated. We observed that the GTI performed equally well in single study settings compared to existing outlier analysis methods. Furthermore, the performance of the GTI method based on discovery studies in glioblastoma and prostate cancer was notable based on the biology of the top genes identified by the GTI. This analysis revealed many genes with outlier expression patterns, and the approach is directly…

Subjects/Keywords: cancer informatics; cancer informatics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mpindi, J. P. (2016). Bioinformatic tools for analysis, mining and modelling large-scale gene expression and drug testing datasets : Bioinformatic tools for analyzing large-scale biomedical datasets. (Doctoral Dissertation). University of Helsinki. Retrieved from http://hdl.handle.net/10138/160326

Chicago Manual of Style (16^th Edition):

Mpindi, John Patrick. “Bioinformatic tools for analysis, mining and modelling large-scale gene expression and drug testing datasets : Bioinformatic tools for analyzing large-scale biomedical datasets.” 2016. Doctoral Dissertation, University of Helsinki. Accessed April 21, 2021. http://hdl.handle.net/10138/160326.

MLA Handbook (7^th Edition):

Mpindi, John Patrick. “Bioinformatic tools for analysis, mining and modelling large-scale gene expression and drug testing datasets : Bioinformatic tools for analyzing large-scale biomedical datasets.” 2016. Web. 21 Apr 2021.

Vancouver:

Mpindi JP. Bioinformatic tools for analysis, mining and modelling large-scale gene expression and drug testing datasets : Bioinformatic tools for analyzing large-scale biomedical datasets. [Internet] [Doctoral dissertation]. University of Helsinki; 2016. [cited 2021 Apr 21]. Available from: http://hdl.handle.net/10138/160326.

Council of Science Editors:

Mpindi JP. Bioinformatic tools for analysis, mining and modelling large-scale gene expression and drug testing datasets : Bioinformatic tools for analyzing large-scale biomedical datasets. [Doctoral Dissertation]. University of Helsinki; 2016. Available from: http://hdl.handle.net/10138/160326

24. Karjalainen, Katja. Candidate therapeutic targets against acute myeloid leukemia identified via screening combinatorial peptide and chemical libraries.

Degree: Department of Biosciences, Biokemia ja biotekniikka; The University of Texas - M. D. Anderson Cancer Center, Houston, Texas, USA, 2015, University of Helsinki

URL: http://hdl.handle.net/10138/154447

► Acute myeloid leukemia (AML), although rare, is highly malignant neoplasms that account for a majority of leukemia-associated deaths. AML results from an over-growth of immature… (more)

▼ Acute myeloid leukemia (AML), although rare, is highly malignant neoplasms that account for a majority of leukemia-associated deaths. AML results from an over-growth of immature myeloid cells in the bone marrow. These cells are functionally abnormal and interfere with the production of normal hematopoietic cells. Despite apparent phenotypic uniformity, AML is a heterogeneous group of myeloid malignancies, in which multiple genetic and epigenetic aberrations accumulate in hematopoietic stem or progenitor cells leading to disturbed cellular growth, proliferation, and differentiation. The nature and number of these AML-associated molecular abnormalities can vary widely among patients. Accordingly, the survival rate also fluctuates greatly, with an average ~25% overall survival rate. Chemotherapy is currently the mainstay treatment option for the patient with AML. However, although required to induce initial remission, chemotherapy contributes to new mutations and clonal evolution, which often leads to disease relapse. Consequently, targeted therapies are urgently needed to eradicate AML cells. One of the major challenges in clinical oncology today is that therapeutic agents cannot be selectively delivered to tumor site without causing toxicity to rest of the body. In addition, tumor microenvironment has a key role in mediating drug efficacy and resistance, which hampers the discovery of clinically relevant drugs. Therefore, functional screening platforms that can identify cancer-specific targets as well as assess the therapeutic relevance of drug candidates within the appropriate disease microenvironment are fundamental in identification of novel targets and therapeutic agents with better attributes than conventional chemotherapy drugs. In our studies, we have used two discovery approaches: (i) a phage display technology that allows the identification of ligands binding to physiologically relevant targets, and (ii) a novel ex vivo screening assay, which allows identification of candidate drugs against leukemia that are effective in the presence of human blood and bone marrow components. Specifically, our studies have elucidated the function of the leukemia invadosome a supramolecular complex containing certain β2 integrins and matrix metalloproteinases in the context of extramedullary leukemia. We show that this complex is essential for extravasation of leukemia cells as well as for leukemia cell growth, and that blocking the function of this complex possesses potent anti-leukemia and anti-invasion effects. We also demonstrate new roles for neuropilin-1 and interleukin-11 receptors in the pathogenesis of leukemia. We show that these membrane-associated proteins are highly expressed in leukemia cell lines as well as in bone marrow samples from leukemia patients. In addition, we show that the ligands binding to these receptors can be utilized in targeted drug delivery. Finally, we developed a new functional ex vivo screening assay to identify candidate anti-leukemia agents in the presence of human blood or…

Subjects/Keywords: Cancer Biology; Cancer Biology

4 more images…

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APA (6^th Edition):

Karjalainen, K. (2015). Candidate therapeutic targets against acute myeloid leukemia identified via screening combinatorial peptide and chemical libraries. (Doctoral Dissertation). University of Helsinki. Retrieved from http://hdl.handle.net/10138/154447

Chicago Manual of Style (16^th Edition):

Karjalainen, Katja. “Candidate therapeutic targets against acute myeloid leukemia identified via screening combinatorial peptide and chemical libraries.” 2015. Doctoral Dissertation, University of Helsinki. Accessed April 21, 2021. http://hdl.handle.net/10138/154447.

MLA Handbook (7^th Edition):

Karjalainen, Katja. “Candidate therapeutic targets against acute myeloid leukemia identified via screening combinatorial peptide and chemical libraries.” 2015. Web. 21 Apr 2021.

Vancouver:

Karjalainen K. Candidate therapeutic targets against acute myeloid leukemia identified via screening combinatorial peptide and chemical libraries. [Internet] [Doctoral dissertation]. University of Helsinki; 2015. [cited 2021 Apr 21]. Available from: http://hdl.handle.net/10138/154447.

Council of Science Editors:

Karjalainen K. Candidate therapeutic targets against acute myeloid leukemia identified via screening combinatorial peptide and chemical libraries. [Doctoral Dissertation]. University of Helsinki; 2015. Available from: http://hdl.handle.net/10138/154447

University of Alberta

25. Khan, Mohammad KA. Population-based evaluation of disparities in survival of lung cancer patients in Alberta, Canada.

Degree: MS, Department of Public Health Sciences, 2014, University of Alberta

URL: https://era.library.ualberta.ca/files/b2773x008

► Lung cancer patients of Alberta have lower relative survival compared to their counterparts in Manitoba, British Columbia and Ontario. We conducted two population-based cancer mortality… (more)

Subjects/Keywords: Cancer Epidemiology/ Cancer Biostatistics

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APA (6^th Edition):

Khan, M. K. (2014). Population-based evaluation of disparities in survival of lung cancer patients in Alberta, Canada. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/b2773x008

Chicago Manual of Style (16^th Edition):

Khan, Mohammad KA. “Population-based evaluation of disparities in survival of lung cancer patients in Alberta, Canada.” 2014. Masters Thesis, University of Alberta. Accessed April 21, 2021. https://era.library.ualberta.ca/files/b2773x008.

MLA Handbook (7^th Edition):

Khan, Mohammad KA. “Population-based evaluation of disparities in survival of lung cancer patients in Alberta, Canada.” 2014. Web. 21 Apr 2021.

Vancouver:

Khan MK. Population-based evaluation of disparities in survival of lung cancer patients in Alberta, Canada. [Internet] [Masters thesis]. University of Alberta; 2014. [cited 2021 Apr 21]. Available from: https://era.library.ualberta.ca/files/b2773x008.

Council of Science Editors:

Khan MK. Population-based evaluation of disparities in survival of lung cancer patients in Alberta, Canada. [Masters Thesis]. University of Alberta; 2014. Available from: https://era.library.ualberta.ca/files/b2773x008

Nelson Mandela Metropolitan University

26. Knoetze, Steyn. The development of novel cancer targeting agents.

Degree: Faculty of Science, 2011, Nelson Mandela Metropolitan University

URL: http://hdl.handle.net/10948/d1010636

► The search for the cure for cancer is currently a multi-billion dollar industry and the search for the elusive “magic bullet”, i.e. the perfect cancer… (more)

▼ The search for the cure for cancer is currently a multi-billion dollar industry and the search for the elusive “magic bullet”, i.e. the perfect cancer drug that would interact therapeutically with cancerous tissues while having a minimal effect on healthy cells, is the topic of many research studies in the world today. A large number of novel drugs or drug complexes and conjugates are being synthesized and subjected to rigorous evaluation in the race to find the perfect cure. ECDG (Ethylene diCysteine DeoxyGlucose) seems to have promising cancer targeting ability. Even though this compound has been described in a few publications, we could not find any reference to the current use of ECDG in oncology clinics, either as a therapeutic agent, or as a diagnostic tool for imaging purposes. It was also not possible to purchase pure ECDG anywhere in the world. This prompted us to further investigate ECDG as a possible candidate for cancer targeting research, either as an imaging agent for cancer diagnosis or complexed with an anti-cancer agent for therapeutic purposes. Detailed investigations done in our laboratory can be divided into the following categories: - Development of a synthetic method for ECDG on a multigram scale ; - Purification of prepared ECDG not using the described dialysis method that only allows the purification of small quantities of ECDG (mg scale) ; Detailed investigation of the chemistry involved in the preparation of pure ECDG and its metal complexes ; - Investigation of the stability of ECDG and its metal complexes that is essential data required for any pharmaceutical agent ; - Preparation of ECDG complexes for use as a diagnostic tool, i.e. complexation with 99mTc ; Investigation of the bio distribution of ECDG-ReO complexes ; - Preparation of an ECDG kit as a diagnostic tool for use in oncology clinics. The development of novel aromatic ligands having similar characteristics compared to ECDG, containing an N2S2 chromophore as donor atoms, to further investigate their targeting capabilities, have also been investigated. All intermediates and final compounds were characterized mainly by ESI MS, in some cases IR and NMR whenever available. Successful preparation and purification of ECDG ands its metal complexes was achieved and extensively characterized and evaluated. Efforts directed towards the development of ECDG at NECSA, South Africa, were also rewarded with significant success. Furthermore, significant development regarding the synthesis of two novel compounds with ECDG-like characteristics was also completed.

Subjects/Keywords: Cancer – Research; Cancer – Treatment

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APA (6^th Edition):

Knoetze, S. (2011). The development of novel cancer targeting agents. (Thesis). Nelson Mandela Metropolitan University. Retrieved from http://hdl.handle.net/10948/d1010636

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Knoetze, Steyn. “The development of novel cancer targeting agents.” 2011. Thesis, Nelson Mandela Metropolitan University. Accessed April 21, 2021. http://hdl.handle.net/10948/d1010636.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Knoetze, Steyn. “The development of novel cancer targeting agents.” 2011. Web. 21 Apr 2021.

Vancouver:

Knoetze S. The development of novel cancer targeting agents. [Internet] [Thesis]. Nelson Mandela Metropolitan University; 2011. [cited 2021 Apr 21]. Available from: http://hdl.handle.net/10948/d1010636.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Knoetze S. The development of novel cancer targeting agents. [Thesis]. Nelson Mandela Metropolitan University; 2011. Available from: http://hdl.handle.net/10948/d1010636

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Anna University

27. Venkataraman D. Analysis of glandular cells in Sputum cytology images for lung Cancer detection;.

Degree: Analysis of glandular cells in Sputum cytology images for lung Cancer detection, 2015, Anna University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/39226

►

One of the biggest challenges the world face today is the mortality newlinedue to Cancer One in four of all diagnosed cancers involve the lung… (more)

Subjects/Keywords: Adenocarcinoma cancer; Cancer detection

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APA (6^th Edition):

D, V. (2015). Analysis of glandular cells in Sputum cytology images for lung Cancer detection;. (Thesis). Anna University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/39226

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

D, Venkataraman. “Analysis of glandular cells in Sputum cytology images for lung Cancer detection;.” 2015. Thesis, Anna University. Accessed April 21, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/39226.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

D, Venkataraman. “Analysis of glandular cells in Sputum cytology images for lung Cancer detection;.” 2015. Web. 21 Apr 2021.

Vancouver:

D V. Analysis of glandular cells in Sputum cytology images for lung Cancer detection;. [Internet] [Thesis]. Anna University; 2015. [cited 2021 Apr 21]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/39226.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

D V. Analysis of glandular cells in Sputum cytology images for lung Cancer detection;. [Thesis]. Anna University; 2015. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/39226

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

McMaster University

28. Hu, Jiarui. Method to estimate cancer overdiagnosis with prostate screening.

Degree: MSc, 2018, McMaster University

URL: http://hdl.handle.net/11375/23969

►

Aim: Several studies have tried to quantify overdiagnosis of prostate cancer with Prostate-specific antigen(PSA) screening, but estimates vary widely. This study aims to evaluate the… (more)

Subjects/Keywords: cancer overdiagnosis; prostate cancer

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hu, J. (2018). Method to estimate cancer overdiagnosis with prostate screening. (Masters Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/23969

Chicago Manual of Style (16^th Edition):

Hu, Jiarui. “Method to estimate cancer overdiagnosis with prostate screening.” 2018. Masters Thesis, McMaster University. Accessed April 21, 2021. http://hdl.handle.net/11375/23969.

MLA Handbook (7^th Edition):

Hu, Jiarui. “Method to estimate cancer overdiagnosis with prostate screening.” 2018. Web. 21 Apr 2021.

Vancouver:

Hu J. Method to estimate cancer overdiagnosis with prostate screening. [Internet] [Masters thesis]. McMaster University; 2018. [cited 2021 Apr 21]. Available from: http://hdl.handle.net/11375/23969.

Council of Science Editors:

Hu J. Method to estimate cancer overdiagnosis with prostate screening. [Masters Thesis]. McMaster University; 2018. Available from: http://hdl.handle.net/11375/23969

Addis Ababa University

29. Atsednesh, Getachew. Psychosocial Impact of Childhood Cancer on Parents with Children Diagnosed with Cancer: The Case of Parents Receiving Service at Tikur Anbessa Specialized Hospital .

Degree: 2014, Addis Ababa University

URL: http://etd.aau.edu.et/dspace/handle/123456789/5483

► Cancer, one of the non-communicable diseases is gaining momentum in Ethiopia. As the country has only one cancer treatment center for both adults and children,… (more)

Subjects/Keywords: Childhood Cancer; Cancer Treatment

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Atsednesh, G. (2014). Psychosocial Impact of Childhood Cancer on Parents with Children Diagnosed with Cancer: The Case of Parents Receiving Service at Tikur Anbessa Specialized Hospital . (Thesis). Addis Ababa University. Retrieved from http://etd.aau.edu.et/dspace/handle/123456789/5483

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Atsednesh, Getachew. “Psychosocial Impact of Childhood Cancer on Parents with Children Diagnosed with Cancer: The Case of Parents Receiving Service at Tikur Anbessa Specialized Hospital .” 2014. Thesis, Addis Ababa University. Accessed April 21, 2021. http://etd.aau.edu.et/dspace/handle/123456789/5483.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Atsednesh, Getachew. “Psychosocial Impact of Childhood Cancer on Parents with Children Diagnosed with Cancer: The Case of Parents Receiving Service at Tikur Anbessa Specialized Hospital .” 2014. Web. 21 Apr 2021.

Vancouver:

Atsednesh G. Psychosocial Impact of Childhood Cancer on Parents with Children Diagnosed with Cancer: The Case of Parents Receiving Service at Tikur Anbessa Specialized Hospital . [Internet] [Thesis]. Addis Ababa University; 2014. [cited 2021 Apr 21]. Available from: http://etd.aau.edu.et/dspace/handle/123456789/5483.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Atsednesh G. Psychosocial Impact of Childhood Cancer on Parents with Children Diagnosed with Cancer: The Case of Parents Receiving Service at Tikur Anbessa Specialized Hospital . [Thesis]. Addis Ababa University; 2014. Available from: http://etd.aau.edu.et/dspace/handle/123456789/5483

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

30. Lopez Almeida, Leonor. Rôle de Lano/LRRC1 dans le cancer du sein et influence sur les cellules souches cancéreuses : Role of Lano/LRRC1 in breast cancer and influence in cancer stem cells.

Degree: Docteur es, Pathologie humaine. Oncologie, 2017, Aix Marseille Université

URL: http://www.theses.fr/2017AIXM0653

►

Les chiffres mondiaux estiment l’incidence du cancer du sein, cancer féminin le plus fréquent, à 1.3 millions de cas par an, dont près d’un tiers… (more)

Subjects/Keywords: Cancer du sein; Breast cancer

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lopez Almeida, L. (2017). Rôle de Lano/LRRC1 dans le cancer du sein et influence sur les cellules souches cancéreuses : Role of Lano/LRRC1 in breast cancer and influence in cancer stem cells. (Doctoral Dissertation). Aix Marseille Université. Retrieved from http://www.theses.fr/2017AIXM0653

Chicago Manual of Style (16^th Edition):

Lopez Almeida, Leonor. “Rôle de Lano/LRRC1 dans le cancer du sein et influence sur les cellules souches cancéreuses : Role of Lano/LRRC1 in breast cancer and influence in cancer stem cells.” 2017. Doctoral Dissertation, Aix Marseille Université. Accessed April 21, 2021. http://www.theses.fr/2017AIXM0653.

MLA Handbook (7^th Edition):

Lopez Almeida, Leonor. “Rôle de Lano/LRRC1 dans le cancer du sein et influence sur les cellules souches cancéreuses : Role of Lano/LRRC1 in breast cancer and influence in cancer stem cells.” 2017. Web. 21 Apr 2021.

Vancouver:

Lopez Almeida L. Rôle de Lano/LRRC1 dans le cancer du sein et influence sur les cellules souches cancéreuses : Role of Lano/LRRC1 in breast cancer and influence in cancer stem cells. [Internet] [Doctoral dissertation]. Aix Marseille Université 2017. [cited 2021 Apr 21]. Available from: http://www.theses.fr/2017AIXM0653.

Council of Science Editors:

Lopez Almeida L. Rôle de Lano/LRRC1 dans le cancer du sein et influence sur les cellules souches cancéreuses : Role of Lano/LRRC1 in breast cancer and influence in cancer stem cells. [Doctoral Dissertation]. Aix Marseille Université 2017. Available from: http://www.theses.fr/2017AIXM0653

Open Access Theses and Dissertations