subject:(cancer)

University of Georgia

1. Thompson, Pamela Sue. Synthesis and immunotherapeutic studies of carbohydrate-based cancer vaccines.

Degree: PhD, Chemistry, 2011, University of Georgia

URL: http://purl.galileo.usg.edu/uga_etd/thompson_pamela_s_201112_phd

► Cancer remains a major cause of death throughout the world. Current treatment of cancer has primarily relied on a combination of therapies, in many cases… (more)

▼ Cancer remains a major cause of death throughout the world. Current treatment of cancer has primarily relied on a combination of therapies, in many cases surgical reduction of the tumor, followed by chemotherapy and radiation, which targets rapidly dividing cells. These treatments, however, do not only affect tumor cells, but also normal cells, resulting in severe side effects. As research has unraveled more details of the intrinsic underlying biological and immunological mechanisms of cancer, new approaches such as angiogenesis inhibitor therapy, gene therapy, and immunotherapy have emerged as possible treatments. The identification of tumor-associated antigens has made it possible to develop antigen-specific vaccines. It has been established that aberrant glycosylation is closely associated with a majority of human cancers. The low antigenicity of tumor-associated carbohydrate antigens signifies a hurdle in vaccine development. In this research, we have examined a three-component vaccine candidate which is able to break tolerance and induce humoral and cellular immune responses against the tumor-associated glycoprotein MUC1, generating CTLs and ADCC-mediating antibodies. This vaccine candidate, which is composed of the tumor-associated antigen MUC1, a promiscuous T-helper peptide derived from the polio virus, and a built-in adjuvant, the TLR2 ligand Pam3CysSK4, demonstrated a superior therapeutic anti-tumor effect in a mouse model of breast cancer. The synthesis of these glycolipopeptide vaccine candidates represents a formidable challenge due to the unique properties of the individual components. In this research, we have developed a highly efficient microwave-assisted liposome-mediated native chemical ligation protocol to obtain cancer vaccine candidates. In our efforts to further streamline the synthesis, we have successfully exploited microwave-assisted solid-phase peptide synthesis (MW-SPPS) for the linear construction of these glycolipopeptides. We applied this technology towards the synthesis of vaccine candidates which contain Pam3CysSK4 and aberrantly glycosylated long MUC1 peptide sequences. Immunization with these vaccine constructs resulted in the production of glycopeptide-specific IgG antibody responses, demonstrating that glycopeptide sequences from MUC1 can be processed and presented to MHC-II. Finally, a strategically protected sialyl-Tn antigen was synthesized in a stereoselective manner and was utilized during the linear assembly of a vaccine candidate via the newly developed MW-SPPS protocol. Advisors/Committee Members: Geert Jan Boons.

Subjects/Keywords: cancer

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Thompson, P. S. (2011). Synthesis and immunotherapeutic studies of carbohydrate-based cancer vaccines. (Doctoral Dissertation). University of Georgia. Retrieved from http://purl.galileo.usg.edu/uga_etd/thompson_pamela_s_201112_phd

Chicago Manual of Style (16^th Edition):

Thompson, Pamela Sue. “Synthesis and immunotherapeutic studies of carbohydrate-based cancer vaccines.” 2011. Doctoral Dissertation, University of Georgia. Accessed March 31, 2020. http://purl.galileo.usg.edu/uga_etd/thompson_pamela_s_201112_phd.

MLA Handbook (7^th Edition):

Thompson, Pamela Sue. “Synthesis and immunotherapeutic studies of carbohydrate-based cancer vaccines.” 2011. Web. 31 Mar 2020.

Vancouver:

Thompson PS. Synthesis and immunotherapeutic studies of carbohydrate-based cancer vaccines. [Internet] [Doctoral dissertation]. University of Georgia; 2011. [cited 2020 Mar 31]. Available from: http://purl.galileo.usg.edu/uga_etd/thompson_pamela_s_201112_phd.

Council of Science Editors:

Thompson PS. Synthesis and immunotherapeutic studies of carbohydrate-based cancer vaccines. [Doctoral Dissertation]. University of Georgia; 2011. Available from: http://purl.galileo.usg.edu/uga_etd/thompson_pamela_s_201112_phd

University of Georgia

2. Ingale, Sampat. Synthesis and immunological evaluation of a three-component cancer vaccine candidate.

Degree: PhD, Chemistry, 2007, University of Georgia

URL: http://purl.galileo.usg.edu/uga_etd/ingale_sampat_200708_phd

► Cancer is an invincible menace that contributes to about 7 million deaths annually, or 12.5% of total annual deaths worldwide. However, advances in surgery, chemotherapy… (more)

▼ Cancer is an invincible menace that contributes to about 7 million deaths annually, or 12.5% of total annual deaths worldwide. However, advances in surgery, chemotherapy and radiation therapy have reduced mortality rates. In this thesis, a novel approach towards the development of a fully synthetic carbohydrate-based cancer vaccine for various forms of human cancers is presented which contains all the necessary components required for cancer immunotherapy. Although the idea of vaccination on a mass scale is more than 200 years old, carbohydrate-based cancer vaccines are still in a developmental and experimental stage. Carbohydrate-based cancer vaccine development has been complicated by the difficulty of eliciting high titers of IgG antibodies in patients. It appears that the induction of IgG antibodies against a tumor-associated carbohydrate is much more difficult than the induction of similar antibodies against viral and bacterial carbohydrates because carbohydrates are auto-antigens and well tolerated by the immune system. Also, carbohydrates are poor immunogens. Some of the obstacles that inhibit the development of a carbohydrate-based cancer vaccine are the availability of pure oligosaccharides, and poor immunogenicity of oligosaccharides. In this research, we have developed a three-component vaccine candidate composed of a tumor-associated antigen, a promiscuous peptide T-helper epitope and a lipopeptide adjuvant. A three-component vaccine has a number of distinctive advantages over a traditional conjugate vaccine. For example, the minimal subunit vaccine does not suffer from epitope suppression, which is a characteristic of carbohydrate-protein conjugates. Apart from providing danger signals, lipopeptide Pam3CysSK4 also facilitates the incorporation of the antigen into liposomes. Finally, a highly convergent method based on sequential native chemical ligation is developed, which allows the construction of three-component vaccine candidates in an efficient manner. This method also allows studying structure-activity relationship (SAR) studies for various components of the vaccine. Besides synthetic chemistry, the research focuses vaccine formulation and immunology. Advisors/Committee Members: Geert-Jan Boons.

Subjects/Keywords: Cancer

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ingale, S. (2007). Synthesis and immunological evaluation of a three-component cancer vaccine candidate. (Doctoral Dissertation). University of Georgia. Retrieved from http://purl.galileo.usg.edu/uga_etd/ingale_sampat_200708_phd

Chicago Manual of Style (16^th Edition):

Ingale, Sampat. “Synthesis and immunological evaluation of a three-component cancer vaccine candidate.” 2007. Doctoral Dissertation, University of Georgia. Accessed March 31, 2020. http://purl.galileo.usg.edu/uga_etd/ingale_sampat_200708_phd.

MLA Handbook (7^th Edition):

Ingale, Sampat. “Synthesis and immunological evaluation of a three-component cancer vaccine candidate.” 2007. Web. 31 Mar 2020.

Vancouver:

Ingale S. Synthesis and immunological evaluation of a three-component cancer vaccine candidate. [Internet] [Doctoral dissertation]. University of Georgia; 2007. [cited 2020 Mar 31]. Available from: http://purl.galileo.usg.edu/uga_etd/ingale_sampat_200708_phd.

Council of Science Editors:

Ingale S. Synthesis and immunological evaluation of a three-component cancer vaccine candidate. [Doctoral Dissertation]. University of Georgia; 2007. Available from: http://purl.galileo.usg.edu/uga_etd/ingale_sampat_200708_phd

Universidade Estadual de Campinas

3. Mariano, Fernanda Viviane, 1984-. Risco de metastases a distancia de carcinomas de glandulas salivares maiores .

Degree: 2009, Universidade Estadual de Campinas

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/289802

► Resumo: As neoplasias de glândulas salivares são raras com incidência anual de 0,4 a 3,5 casos por 100.000 pessoas. Correspondem a cerca de 2 a… (more)

▼ Resumo: As neoplasias de glândulas salivares são raras com incidência anual de 0,4 a 3,5 casos por 100.000 pessoas. Correspondem a cerca de 2 a 6,5% de todos os tumores da egião de cabeça e pescoço. A freqüência de neoplasias malignas varia de 0,4 a 2,6 casos por 100.000 pessoas e o tipo mais comum é o carcinoma mucoepidermóide. O local mais freqüentemente acometido é a glândula parótida, seguida das glândulas salivares menores, submandibular e sublingual. A probabilidade de pacientes com tumores de glândulas salivares desenvolverem metástases à distância está associada com o tipo histológico dos tumores, sendo mais comumente relacionada ao carcinoma adenóide cístico, carcinoma mucoepidermóide de alto grau, carcinoma de ducto salivar e tumores localizados na glândula submandibular, base de língua e tumores faringeanos. O objetivo deste estudo foi avaliar as características clínicas e histopatológicas de carcinomas de glândulas salivares maiores tratados no Hospital A.C. Camargo, São Paulo, de 1953 a 2004, a fim de identificar fatores de risco associados ao desenvolvimento de metástases à distância e sua importância prognóstica. Os dados clínicos foram obtidos através dos prontuários médicos dos pacientes e transferidos para fichas clínicas padronizadas para o estudo. O número total de casos estudados foi de 255, dos quais 57 pacientes desenvolveram metástases à distância, sendo a glândula submandibular o local primário mais relacionado e o pulmão o sítio metastático mais comum. Não houve diferença estatística entre os gêneros. O tipo histológico mais encontrado nos casos com metástase foi o carcinoma adenóide cístico. Os fatores associados a pior prognóstico foram: ocorrência de paralisia facial, invasão de estruturas adjacentes, tumores localizados na glândula submandibular, comprometimento linfonodal, estádio clínico avançado, presença de tumor residual e desenvolvimento de metástase à distância. Os resultados deste trabalho permitiram obter informações sobre as principais características clínicas e patológicas dos carcinomas de glândulas salivares maiores e identificar que indivíduos portadores de carcinoma adenóide cístico apresentam o maior risco de desenvolvimento de metástase à distância.; Abstract: Salivary gland tumors are rare with annual incidence around of 0.4 to 13.5 cases per 100,000 people. They correspond about 2 to 6.5% of all tumors from head and neck region. The frequency of malignant tumors varies from 0.4 to 2.6 cases per 100,000 people and the more common type is the mucoepidermoid carcinoma, occurring preferentially in the parotid gland, followed of minor salivary glands, submandibular and sublingual. The probability of patients with salivary gland tumors to develop distant metastasis is associate with histology type of tumor, being more commonly related with adenoid cystic carcinoma, high-grade mucoepidermoid carcinoma, salivary duct carcinoma and tumors localized in the submandibular gland, base of the tongue, and pharynx. The objective of this study was to evaluate the clinical… Advisors/Committee Members: Kowalski, Luiz Paulo (advisor), Almeida, Oslei Paes de, 1948- (advisor), Magrim, Jose (committee member), Lopes, Marcio Ajudarte (committee member).

Subjects/Keywords: Cancer

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mariano, Fernanda Viviane, 1. (2009). Risco de metastases a distancia de carcinomas de glandulas salivares maiores . (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/289802

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mariano, Fernanda Viviane, 1984-. “Risco de metastases a distancia de carcinomas de glandulas salivares maiores .” 2009. Thesis, Universidade Estadual de Campinas. Accessed March 31, 2020. http://repositorio.unicamp.br/jspui/handle/REPOSIP/289802.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mariano, Fernanda Viviane, 1984-. “Risco de metastases a distancia de carcinomas de glandulas salivares maiores .” 2009. Web. 31 Mar 2020.

Vancouver:

Mariano, Fernanda Viviane 1. Risco de metastases a distancia de carcinomas de glandulas salivares maiores . [Internet] [Thesis]. Universidade Estadual de Campinas; 2009. [cited 2020 Mar 31]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/289802.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mariano, Fernanda Viviane 1. Risco de metastases a distancia de carcinomas de glandulas salivares maiores . [Thesis]. Universidade Estadual de Campinas; 2009. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/289802

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

4. Fergione, Sarah J. Engineering 3D Human Cortical Microtissues Harboring Patient-Derived Glioblastomas.

Degree: Department of Molecular Pharmacology, Physiology and Biotechnology, 2018, Brown University

URL: https://repository.library.brown.edu/studio/item/bdr:792897/

► Human glioblastomas develop within the brain parenchyma in which there is continuous interaction of glioma cells with axon fibers, glial cells and endothelial cells. This… (more)

▼ Human glioblastomas develop within the brain parenchyma in which there is continuous interaction of glioma cells with axon fibers, glial cells and endothelial cells. This cellular interplay cannot be accounted for with the current monolayer in vitro models. Moreover, the development of new therapies against glioblastoma has often failed due to toxicities that were not identified through in vitro studies and animal testing. To mitigate some of these limitations, we have developed an all human ex vivo 3D glioblastoma model. ReNcell CX cells, an immortalized human neural progenitor cell line, were used as the base of the 3D model. ReNcell CX cells were seeded into micromolds to form self-assembled spheroids and subsequently induced to differentiate. After 46 days of differentiation, spheroids were fixed, embedded, and cryosectioned for immunostaining to confirm assembly of polarized cortical microtissues. N-cadherin is essential for maintaining the polarized architecture of neuroepithelial cells in the cerebral cortex through the formation of adherent junctions. We show that our human cortical spheroids express N-cadherin in a polarized pattern close to the apical surface of the spheroids. To verify the presence of neocortical progenitors we stained with Pax6, while the presence of mature cortical neurons was verified with TuJ and Bf1 staining. To investigate the invasion of glioma cells into the human cortical spheroids, a confrontation assay between cortical and glioma spheroids was implemented. Finally, spheroids were fixed and stained using combinations of glioma cell and cortical neuron specific markers. The proposed model aims to mitigate some of the limitations in current in vitro and in vivo approaches. Our 3D human brain microtissues will be used to gain a more in-depth understanding of the origins of brain cancer, including the migration and invasion of glioblastoma into the brain parenchyma, and serve as drug development platform to test novel cancer therapeutics. Advisors/Committee Members: Morgan, Jeff (Advisor), Ip, Blanche (Reader), Tapinos, Nikos (Advisor).

Subjects/Keywords: Cancer

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Fergione, S. J. (2018). Engineering 3D Human Cortical Microtissues Harboring Patient-Derived Glioblastomas. (Thesis). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:792897/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Fergione, Sarah J. “Engineering 3D Human Cortical Microtissues Harboring Patient-Derived Glioblastomas.” 2018. Thesis, Brown University. Accessed March 31, 2020. https://repository.library.brown.edu/studio/item/bdr:792897/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Fergione, Sarah J. “Engineering 3D Human Cortical Microtissues Harboring Patient-Derived Glioblastomas.” 2018. Web. 31 Mar 2020.

Vancouver:

Fergione SJ. Engineering 3D Human Cortical Microtissues Harboring Patient-Derived Glioblastomas. [Internet] [Thesis]. Brown University; 2018. [cited 2020 Mar 31]. Available from: https://repository.library.brown.edu/studio/item/bdr:792897/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Fergione SJ. Engineering 3D Human Cortical Microtissues Harboring Patient-Derived Glioblastomas. [Thesis]. Brown University; 2018. Available from: https://repository.library.brown.edu/studio/item/bdr:792897/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

5. Smith, Tyler. The Role of the Transcription Factor SREBP2 in Glioblastoma Cancer Cells.

Degree: Biomedical Engineering, 2017, Brown University

URL: https://repository.library.brown.edu/studio/item/bdr:733518/

► Abstract of The Role of the Transcription Factor SREBP2 in Glioblastoma Cancer Cells, by Tyler Smith, ScM., Brown University, May 2018. Cholesterol is a vital… (more)

Subjects/Keywords: Cancer

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Smith, T. (2017). The Role of the Transcription Factor SREBP2 in Glioblastoma Cancer Cells. (Thesis). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:733518/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Smith, Tyler. “The Role of the Transcription Factor SREBP2 in Glioblastoma Cancer Cells.” 2017. Thesis, Brown University. Accessed March 31, 2020. https://repository.library.brown.edu/studio/item/bdr:733518/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Smith, Tyler. “The Role of the Transcription Factor SREBP2 in Glioblastoma Cancer Cells.” 2017. Web. 31 Mar 2020.

Vancouver:

Smith T. The Role of the Transcription Factor SREBP2 in Glioblastoma Cancer Cells. [Internet] [Thesis]. Brown University; 2017. [cited 2020 Mar 31]. Available from: https://repository.library.brown.edu/studio/item/bdr:733518/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Smith T. The Role of the Transcription Factor SREBP2 in Glioblastoma Cancer Cells. [Thesis]. Brown University; 2017. Available from: https://repository.library.brown.edu/studio/item/bdr:733518/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Debrecen

6. Gurpinar, Melisa. Different Types of Cancer .

Degree: DE – TEK – Természettudományi és Technológiai Kar – Biológiai és Ökológiai Intézet, 2012, University of Debrecen

URL: http://hdl.handle.net/2437/128533

Cancer is a leading cause of death worldwide and according to WHO (World Health Organisation) 7.6 million people worldwide died from cancer in 2008, and 30% of cancer could be prevented. Advisors/Committee Members: Bánfalvi, Gáspár (advisor).

Subjects/Keywords: Cancer

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gurpinar, M. (2012). Different Types of Cancer . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/128533

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gurpinar, Melisa. “Different Types of Cancer .” 2012. Thesis, University of Debrecen. Accessed March 31, 2020. http://hdl.handle.net/2437/128533.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gurpinar, Melisa. “Different Types of Cancer .” 2012. Web. 31 Mar 2020.

Vancouver:

Gurpinar M. Different Types of Cancer . [Internet] [Thesis]. University of Debrecen; 2012. [cited 2020 Mar 31]. Available from: http://hdl.handle.net/2437/128533.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gurpinar M. Different Types of Cancer . [Thesis]. University of Debrecen; 2012. Available from: http://hdl.handle.net/2437/128533

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Arizona

7. Mendoza, Erin. Role of p53 in Adaptation to the Tumor Microenvironment .

Degree: 2010, University of Arizona

URL: http://hdl.handle.net/10150/204113

► Tumors cells grow in nutrient and oxygen-deprived microenvironments and adapt to the suboptimal growth conditions by altering their metabolic pathways. The adaptation process commonly creates… (more)

▼ Tumors cells grow in nutrient and oxygen-deprived microenvironments and adapt to the suboptimal growth conditions by altering their metabolic pathways. The adaptation process commonly creates a tumor phenotype of high glycolytic potential and aggressive growth characteristics which facilitate metastasis and confer resistance to radiation and chemotherapy. Understanding the mechanisms that allow tumors to adapt and survive in their microenvironment is crucial to cancer prevention and control. It was hypothesized that the tumor microenvironment would induce signaling and enzymatic changes, which if manipulated could improve treatment outcome. The results presented here demonstrate that exposure of tumor cells to chronic low pH or hypoxic conditions induced signaling cascades and altered enzyme profiles which resulted in a pro-survival phenotype. Three key adaptation events were observed and included 1) the up regulation of the metabolic stress and glycolytic proteins AMP-activated protein kinase (AMPK) and 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3 (PFKFB3), respectfully. 2) The upregulation of p53 and 3) changes in the ratios of the bioreductive enzymes were also found to be important in the adaptation. The tumor suppressor p53 played a central role in adaptation because it induced the transcription of anti-glycolytic proteins to control glycolysis and minimize tumor cell acidosis. The ratio of bioreductive enzymes was also altered by changes to the microenvironment. Hypoxia had the greatest effect on protein levels and caused a decrease in the ratio of NAD(P)H:quinone oxidoreductase 1 (NQO1): cytochrome p450 reductase. The increase in cytochrome p450 reductase, a one electron bioreduction enzyme, has been shown to increase toxicity of bioreductive drugs in hypoxic tumors. Micronutrients also had an effect on p53 homeostasis because increasing NQO1 activity by riboflavin supplementation induced a p53-stabilizing effect by enhancing binding of p53 to NQO1, protecting the tumor suppressor from degradation. Taken together, these results indicate the changes that occur in tumor adaptation to the microenvironment require signaling and enzymatic changes that work in concert to regulate metabolism and apoptosis. Many of these changes present therapeutic targets that could be exploited to enhance therapy or prevent adaptation and subsequent tumor growth. Advisors/Committee Members: Burd, Randy M (advisor), Limesand, Kirsten H. (committeemember), Romagnolo, Donato F. (committeemember), Baker, Amanda F. (committeemember), Guerriero, Vince (committeemember).

Subjects/Keywords: Cancer

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mendoza, E. (2010). Role of p53 in Adaptation to the Tumor Microenvironment . (Doctoral Dissertation). University of Arizona. Retrieved from http://hdl.handle.net/10150/204113

Chicago Manual of Style (16^th Edition):

Mendoza, Erin. “Role of p53 in Adaptation to the Tumor Microenvironment .” 2010. Doctoral Dissertation, University of Arizona. Accessed March 31, 2020. http://hdl.handle.net/10150/204113.

MLA Handbook (7^th Edition):

Mendoza, Erin. “Role of p53 in Adaptation to the Tumor Microenvironment .” 2010. Web. 31 Mar 2020.

Vancouver:

Mendoza E. Role of p53 in Adaptation to the Tumor Microenvironment . [Internet] [Doctoral dissertation]. University of Arizona; 2010. [cited 2020 Mar 31]. Available from: http://hdl.handle.net/10150/204113.

Council of Science Editors:

Mendoza E. Role of p53 in Adaptation to the Tumor Microenvironment . [Doctoral Dissertation]. University of Arizona; 2010. Available from: http://hdl.handle.net/10150/204113

8. Graham, Elizabeth Grace. Polymer Dynamic Organic Theranostic Spheres for Photothermal Therapy and Fluorescent Imaging of Cancer.

Degree: 2015, Wake Forest University

URL: http://hdl.handle.net/10339/57185

► Nanoparticle mediated photothermal ablation of cancer is a promising technique that utilizes light energy to destroy cancer cells. Specifically, nanoparticles that absorb in the near… (more)

Subjects/Keywords: cancer

11 more images…

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Graham, E. G. (2015). Polymer Dynamic Organic Theranostic Spheres for Photothermal Therapy and Fluorescent Imaging of Cancer. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/57185

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Graham, Elizabeth Grace. “Polymer Dynamic Organic Theranostic Spheres for Photothermal Therapy and Fluorescent Imaging of Cancer.” 2015. Thesis, Wake Forest University. Accessed March 31, 2020. http://hdl.handle.net/10339/57185.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Graham, Elizabeth Grace. “Polymer Dynamic Organic Theranostic Spheres for Photothermal Therapy and Fluorescent Imaging of Cancer.” 2015. Web. 31 Mar 2020.

Vancouver:

Graham EG. Polymer Dynamic Organic Theranostic Spheres for Photothermal Therapy and Fluorescent Imaging of Cancer. [Internet] [Thesis]. Wake Forest University; 2015. [cited 2020 Mar 31]. Available from: http://hdl.handle.net/10339/57185.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Graham EG. Polymer Dynamic Organic Theranostic Spheres for Photothermal Therapy and Fluorescent Imaging of Cancer. [Thesis]. Wake Forest University; 2015. Available from: http://hdl.handle.net/10339/57185

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Oregon State University

9. Le, Uyen Minh. Improving the uptake and retention of gadolinium in tumors for potential gadolinium-neutron capture therapy: Integration of gemcitabine or localized irradiation into dsRNA therapy significantly enhanced the resultant anti-tumor activity.

Degree: PhD, Pharmacy, 2008, Oregon State University

URL: http://hdl.handle.net/1957/9442

► Cancer is one of the leading causes of death in the U.S., and new approaches to control cancer are constantly sought. This dissertation is comprised… (more)

▼ Cancer is one of the leading causes of death in the U.S., and new approaches to control cancer are constantly sought. This dissertation is comprised of two parts: (i) improving the uptake and retention of gadolinium in tumors for potential gadoliniumneutron capture therapy (Gd-NCT) and (ii) integration of gemcitabine or localized irradiation into dsRNA therapy significantly enhanced the resultant anti-tumor activity. One of the key factors for a successful Gd-NCT is to deliver and maintain a sufficient amount of Gd in tumor tissues (50-200 μg of Gd/g of wet tumor) during neutron irradiation, which has proven to be challenging to achieve. A gadolinium-encapsulated liposome (Gd-liposome) formulation was designed to address this need. The formulation was prepared by complexing diethylenetriaminepentaacetic acid (Gd- DTPA) with poly-L-lysine and then encapsulating the Gd-DTPA complexes intopegylated liposomes. The Gd-liposome formulation delivered as high as 159 μg of pure Gd per g of wet tumor tissue into model tumors in mice. A liposome-in-thermosensitive gel system that significantly extended the retention of the Gd in model tumors in mice was also designed. These Gd delivery systems may be used to deliver Gd into solid tumors for NCT and tumor imaging. Despite of the potent tumoricidal activity of polyinosine-cytosine (e.g. poly(I:C)), a synthetic dsRNA, in culture, its in vivo anti-tumor activity has proven to be limited. Gemcitabine, a chemotherapy agent, or localized x-ray radiation was successfully integrated into poly(I:C) therapy to improve the resultant anti-tumor activity in murine tumor models. Combining gemcitabine with poly(I:C) synergistically inhibited the growth of model tumors in mice and also generated a strong and durable tumorspecific immune response. Alternatively, integrating localized x-ray radiation into poly(I:C) therapy significantly delayed the tumor growth, but the combined activity was synergistic only in mice with highly immunogenic tumors, indicating that the T cell-mediated immunity was responsible for the synergy. The type I interferons (IFN- α/β) induced by poly(I:C) played a critical role in the resultant anti-tumor activity. These combination therapies may represent a promising approach to improve the clinical outcomes of poly(I:C) therapy. Advisors/Committee Members: CUI, ZHENGRONG (advisor), CHRISTENSEN, JOHN MARK (committee member).

Subjects/Keywords: cancer; Cancer – Radiotherapy

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Le, U. M. (2008). Improving the uptake and retention of gadolinium in tumors for potential gadolinium-neutron capture therapy: Integration of gemcitabine or localized irradiation into dsRNA therapy significantly enhanced the resultant anti-tumor activity. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/9442

Chicago Manual of Style (16^th Edition):

Le, Uyen Minh. “Improving the uptake and retention of gadolinium in tumors for potential gadolinium-neutron capture therapy: Integration of gemcitabine or localized irradiation into dsRNA therapy significantly enhanced the resultant anti-tumor activity.” 2008. Doctoral Dissertation, Oregon State University. Accessed March 31, 2020. http://hdl.handle.net/1957/9442.

MLA Handbook (7^th Edition):

Le, Uyen Minh. “Improving the uptake and retention of gadolinium in tumors for potential gadolinium-neutron capture therapy: Integration of gemcitabine or localized irradiation into dsRNA therapy significantly enhanced the resultant anti-tumor activity.” 2008. Web. 31 Mar 2020.

Vancouver:

Le UM. Improving the uptake and retention of gadolinium in tumors for potential gadolinium-neutron capture therapy: Integration of gemcitabine or localized irradiation into dsRNA therapy significantly enhanced the resultant anti-tumor activity. [Internet] [Doctoral dissertation]. Oregon State University; 2008. [cited 2020 Mar 31]. Available from: http://hdl.handle.net/1957/9442.

Council of Science Editors:

Le UM. Improving the uptake and retention of gadolinium in tumors for potential gadolinium-neutron capture therapy: Integration of gemcitabine or localized irradiation into dsRNA therapy significantly enhanced the resultant anti-tumor activity. [Doctoral Dissertation]. Oregon State University; 2008. Available from: http://hdl.handle.net/1957/9442

10. Funsani, Peter. Morbidity and mortality trend analysis of cervical cancer in Zambia for the period 2007 to 2014: a case of Cancer Diseases Hospital.

Degree: 2016, University of Zimbabwe

URL: http://dspace.unza.zm/handle/123456789/4885

► In 2014 alone, over 3 million women aged ≥15 years were at risk of being diagnosed with cervical cancer in Zambia. Our study aimed at… (more)

Subjects/Keywords: Cervical Cancer; Cancer

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Funsani, P. (2016). Morbidity and mortality trend analysis of cervical cancer in Zambia for the period 2007 to 2014: a case of Cancer Diseases Hospital. (Thesis). University of Zimbabwe. Retrieved from http://dspace.unza.zm/handle/123456789/4885

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Funsani, Peter. “Morbidity and mortality trend analysis of cervical cancer in Zambia for the period 2007 to 2014: a case of Cancer Diseases Hospital.” 2016. Thesis, University of Zimbabwe. Accessed March 31, 2020. http://dspace.unza.zm/handle/123456789/4885.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Funsani, Peter. “Morbidity and mortality trend analysis of cervical cancer in Zambia for the period 2007 to 2014: a case of Cancer Diseases Hospital.” 2016. Web. 31 Mar 2020.

Vancouver:

Funsani P. Morbidity and mortality trend analysis of cervical cancer in Zambia for the period 2007 to 2014: a case of Cancer Diseases Hospital. [Internet] [Thesis]. University of Zimbabwe; 2016. [cited 2020 Mar 31]. Available from: http://dspace.unza.zm/handle/123456789/4885.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Funsani P. Morbidity and mortality trend analysis of cervical cancer in Zambia for the period 2007 to 2014: a case of Cancer Diseases Hospital. [Thesis]. University of Zimbabwe; 2016. Available from: http://dspace.unza.zm/handle/123456789/4885

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of New Mexico

11. Smith, Randi L. Tumor Promoting Properties of Field Cancerized Fibroblasts in Cell Culture.

Degree: Biomedical Sciences Graduate Program, 2015, University of New Mexico

URL: https://digitalrepository.unm.edu/biom_etds/93

► Our recent studies have shown that Tumor Adjacent Histologically Normal (TAHN) breast tissue demonstrates many of the characteristics of breast tumors. For example, through immunohistochemical… (more)

Subjects/Keywords: Cancer; Breast Cancer

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Smith, R. L. (2015). Tumor Promoting Properties of Field Cancerized Fibroblasts in Cell Culture. (Masters Thesis). University of New Mexico. Retrieved from https://digitalrepository.unm.edu/biom_etds/93

Chicago Manual of Style (16^th Edition):

Smith, Randi L. “Tumor Promoting Properties of Field Cancerized Fibroblasts in Cell Culture.” 2015. Masters Thesis, University of New Mexico. Accessed March 31, 2020. https://digitalrepository.unm.edu/biom_etds/93.

MLA Handbook (7^th Edition):

Smith, Randi L. “Tumor Promoting Properties of Field Cancerized Fibroblasts in Cell Culture.” 2015. Web. 31 Mar 2020.

Vancouver:

Smith RL. Tumor Promoting Properties of Field Cancerized Fibroblasts in Cell Culture. [Internet] [Masters thesis]. University of New Mexico; 2015. [cited 2020 Mar 31]. Available from: https://digitalrepository.unm.edu/biom_etds/93.

Council of Science Editors:

Smith RL. Tumor Promoting Properties of Field Cancerized Fibroblasts in Cell Culture. [Masters Thesis]. University of New Mexico; 2015. Available from: https://digitalrepository.unm.edu/biom_etds/93

University of Tasmania

12. Breaden, Katrina. Cancer and beyond : the question of survivorship.

Degree: 1995, University of Tasmania

URL: https://eprints.utas.edu.au/18855/1/whole_BreadenKatrina1995_thesis.pdf

► In Australia, as in many other countries in the Western world, the five year survival rate for persons diagnosed with cancer is now approaching 50… (more)

Subjects/Keywords: Cancer; Cancer; Cancer

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Breaden, K. (1995). Cancer and beyond : the question of survivorship. (Thesis). University of Tasmania. Retrieved from https://eprints.utas.edu.au/18855/1/whole_BreadenKatrina1995_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Breaden, Katrina. “Cancer and beyond : the question of survivorship.” 1995. Thesis, University of Tasmania. Accessed March 31, 2020. https://eprints.utas.edu.au/18855/1/whole_BreadenKatrina1995_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Breaden, Katrina. “Cancer and beyond : the question of survivorship.” 1995. Web. 31 Mar 2020.

Vancouver:

Breaden K. Cancer and beyond : the question of survivorship. [Internet] [Thesis]. University of Tasmania; 1995. [cited 2020 Mar 31]. Available from: https://eprints.utas.edu.au/18855/1/whole_BreadenKatrina1995_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Breaden K. Cancer and beyond : the question of survivorship. [Thesis]. University of Tasmania; 1995. Available from: https://eprints.utas.edu.au/18855/1/whole_BreadenKatrina1995_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Tasmania

13. Jones, Catherine Cheryl. Two worlds in one : the lived experiences of seven people treated with autologous bone marrow/peripheral blood stem cell transplant.

Degree: 1996, University of Tasmania

URL: https://eprints.utas.edu.au/20373/1/whole_JonesCatherineCheryl1997_thesis.pdf

► Autologous bone marrow/peripheral blood stem cell transplant is one of the recent treatments to offer hope of a cure or prolonged remission for certain types… (more)

Subjects/Keywords: Cancer; Cancer; Cancer

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Jones, C. C. (1996). Two worlds in one : the lived experiences of seven people treated with autologous bone marrow/peripheral blood stem cell transplant. (Thesis). University of Tasmania. Retrieved from https://eprints.utas.edu.au/20373/1/whole_JonesCatherineCheryl1997_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jones, Catherine Cheryl. “Two worlds in one : the lived experiences of seven people treated with autologous bone marrow/peripheral blood stem cell transplant.” 1996. Thesis, University of Tasmania. Accessed March 31, 2020. https://eprints.utas.edu.au/20373/1/whole_JonesCatherineCheryl1997_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jones, Catherine Cheryl. “Two worlds in one : the lived experiences of seven people treated with autologous bone marrow/peripheral blood stem cell transplant.” 1996. Web. 31 Mar 2020.

Vancouver:

Jones CC. Two worlds in one : the lived experiences of seven people treated with autologous bone marrow/peripheral blood stem cell transplant. [Internet] [Thesis]. University of Tasmania; 1996. [cited 2020 Mar 31]. Available from: https://eprints.utas.edu.au/20373/1/whole_JonesCatherineCheryl1997_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jones CC. Two worlds in one : the lived experiences of seven people treated with autologous bone marrow/peripheral blood stem cell transplant. [Thesis]. University of Tasmania; 1996. Available from: https://eprints.utas.edu.au/20373/1/whole_JonesCatherineCheryl1997_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Université de Grenoble

14. Sambourg, Laure. Décrypter les données omiques : importance du contrôle qualité. Application au cancer de l'ovaire : Decipher omics data, on the importance of quality control.

Degree: Docteur es, Modèles, méthodes et algorithmes en biologie, santé et environnement, 2013, Université de Grenoble

URL: http://www.theses.fr/2013GRENS027

►

Décrypter les données omiques : importance du contrôle qualité. Application au cancer de l’ovaire Au cours des dix dernières années, la taille et la complexité… (more)

▼

Décrypter les données omiques : importance du contrôle qualité. Application au cancer de l’ovaire Au cours des dix dernières années, la taille et la complexité des données biologiques ont littéralement explosé, et une attention particulière doit être portée au contrôle qualité. En effet, certaines données omiques (données génomiques et post-génomiques obtenues à haut débit) sont très incomplètes et/ou contiennent de nombreux biais et erreurs qu’il est facile de confondre avec de l’information biologiquement intéressante. Dans cette thèse, nous montrons que les interactions protéine-protéine issues de curation de la littérature et les interactions identifiées à haut débit sont beaucoup plus corrélées que ce qui est communément admis. Nous examinons l’interactome de la levure d’un point de vue original, en prenant en compte le degré d’étude des protéines par la communauté scientifique et nos résultats indiquent que cette corrélation s’estompe lorsqu’on se restreint aux protéines très étudiées. Ces observations nous permettent de proposer une méthode simple et fiable pour estimer la taille d’un interactome. Notre méthode conduit à une estimation d’au moins 37 600 interactions physiques directes chez S. cerevisiae, et montre que les évaluations précédentes sont trop faibles. Par ailleurs, nous étudions des données de séquençage nouvelle génération de l’ADN. Par une analyse des biais existant entre les short-reads alignés sur un brin ou sur l’autre du génome, nous mettons en évidence de nombreuses erreurs systématiques. De plus, nous observons de multiples positions présentant entre 20 et 40% de short-reads portant l’allèle variant : celles-ci ne peuvent pas être génotypées correctement. Nous proposons une méthode fiable pour appeler les génotypes à partir des données NGS qui permet de s’affranchir de ses difficultés. Enfin, nous appliquons cette méthode sur des données massives de séquençage d’exome de cellules saines et tumorales de 520 patientes atteintes du cancer de l’ovaire, produites par le consortium TCGA. Nous détectons en moyenne 30 632 variants germinaux par patiente. Parmi ces variants, nous identifions ceux les plus enclins à conférer un risque accru de développer la maladie : nous nous restreignons notamment aux variants induisant une perte de fonction de la protéine encodée et significativement plus présents chez les patientes que dans la population générale. Cela conduit à 44 SNVs par patiente en moyenne, répartis sur 334 gènes dans l’ensemble de la cohorte. Parmi ces 334 gènes, 42 ont été reportés comme impliqués dans la cancerogénèse, confirmant que la liste de candidats identifiés est fortement enrichie en gènes de susceptibilité au cancer de l’ovaire. En particulier, nos travaux confirment le rôle de suppresseur de tumeur de la protéine MAP3K8, très récemment proposée comme jouant un rôle clé dans d’autres cancers.

Deciphering omics data : on the importance of quality control. Application to ovarian cancer. Over the past 10 years, the size and complexity of biological data have exploded, and quality…

Advisors/Committee Members: Thierry-Mieg, Nicolas (thesis director).

Subjects/Keywords: NGS; Interactomique; Cancer; Cancer; Interactomic; Cancer; 610

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sambourg, L. (2013). Décrypter les données omiques : importance du contrôle qualité. Application au cancer de l'ovaire : Decipher omics data, on the importance of quality control. (Doctoral Dissertation). Université de Grenoble. Retrieved from http://www.theses.fr/2013GRENS027

Chicago Manual of Style (16^th Edition):

Sambourg, Laure. “Décrypter les données omiques : importance du contrôle qualité. Application au cancer de l'ovaire : Decipher omics data, on the importance of quality control.” 2013. Doctoral Dissertation, Université de Grenoble. Accessed March 31, 2020. http://www.theses.fr/2013GRENS027.

MLA Handbook (7^th Edition):

Sambourg, Laure. “Décrypter les données omiques : importance du contrôle qualité. Application au cancer de l'ovaire : Decipher omics data, on the importance of quality control.” 2013. Web. 31 Mar 2020.

Vancouver:

Sambourg L. Décrypter les données omiques : importance du contrôle qualité. Application au cancer de l'ovaire : Decipher omics data, on the importance of quality control. [Internet] [Doctoral dissertation]. Université de Grenoble; 2013. [cited 2020 Mar 31]. Available from: http://www.theses.fr/2013GRENS027.

Council of Science Editors:

Sambourg L. Décrypter les données omiques : importance du contrôle qualité. Application au cancer de l'ovaire : Decipher omics data, on the importance of quality control. [Doctoral Dissertation]. Université de Grenoble; 2013. Available from: http://www.theses.fr/2013GRENS027

15. Elango, J Kalavathy. Risk profile of oral cancers and strategies to improve awareness and early detection.

Degree: 2009, Amrita Vishwa Vidyapeetham (University)

URL: http://shodhganga.inflibnet.ac.in/handle/10603/2363

►

Fundamentals of implementing any cancer control programs are the understanding of the burden of the disease in the community (incidence trends), risk factor profile and… (more)

Subjects/Keywords: Oral cancer; Oncology; Cancer prevention; Cancer treatment

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Elango, J. K. (2009). Risk profile of oral cancers and strategies to improve awareness and early detection. (Thesis). Amrita Vishwa Vidyapeetham (University). Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/2363

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Elango, J Kalavathy. “Risk profile of oral cancers and strategies to improve awareness and early detection.” 2009. Thesis, Amrita Vishwa Vidyapeetham (University). Accessed March 31, 2020. http://shodhganga.inflibnet.ac.in/handle/10603/2363.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Elango, J Kalavathy. “Risk profile of oral cancers and strategies to improve awareness and early detection.” 2009. Web. 31 Mar 2020.

Vancouver:

Elango JK. Risk profile of oral cancers and strategies to improve awareness and early detection. [Internet] [Thesis]. Amrita Vishwa Vidyapeetham (University); 2009. [cited 2020 Mar 31]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/2363.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Elango JK. Risk profile of oral cancers and strategies to improve awareness and early detection. [Thesis]. Amrita Vishwa Vidyapeetham (University); 2009. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/2363

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universiteit Utrecht

16. Yilmaz, V. Cancer Immunotherapy.

Degree: 2012, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/253742

► Cancer is the leading cause of death in economically developed countries and the conventional anti-cancer therapies fail to meet the criteria of an ideal, safe… (more)

Subjects/Keywords: Cancer; Immunotherapy; cancer immunology; cancer treatment

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Yilmaz, V. (2012). Cancer Immunotherapy. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/253742

Chicago Manual of Style (16^th Edition):

Yilmaz, V. “Cancer Immunotherapy.” 2012. Masters Thesis, Universiteit Utrecht. Accessed March 31, 2020. http://dspace.library.uu.nl:8080/handle/1874/253742.

MLA Handbook (7^th Edition):

Yilmaz, V. “Cancer Immunotherapy.” 2012. Web. 31 Mar 2020.

Vancouver:

Yilmaz V. Cancer Immunotherapy. [Internet] [Masters thesis]. Universiteit Utrecht; 2012. [cited 2020 Mar 31]. Available from: http://dspace.library.uu.nl:8080/handle/1874/253742.

Council of Science Editors:

Yilmaz V. Cancer Immunotherapy. [Masters Thesis]. Universiteit Utrecht; 2012. Available from: http://dspace.library.uu.nl:8080/handle/1874/253742

17. Little, Nicole S. Investigating the co-evolution of tumor antigens and the anti-tumor immune response.

Degree: Department of Biochemistry and Microbiology, 2017, University of Victoria

URL: https://dspace.library.uvic.ca//handle/1828/8503

► Background: High-grade serous carcinoma (HGSC) can exhibit high intratumoral heterogeneity (ITH). Despite a strong association between tumor-infiltrating lymphocytes (TIL) and survival in HGSC, ITH may… (more)

▼ Background: High-grade serous carcinoma (HGSC) can exhibit high intratumoral heterogeneity (ITH). Despite a strong association between tumor-infiltrating lymphocytes (TIL) and survival in HGSC, ITH may have profound impacts on the anti-tumor T cell response. Yet, it is unknown how anti-tumor T cell responses contend with ITH over time in HGSC. Previous studies in melanoma and HGSC both showed tumor-reactive T cell clones emerge over time with their cognate tumor-antigens. Therefore, I hypothesized patients would share a common mechanism of T cell evolution to respond to ITH in HGSC. If so, I expect to see similar patterns of tumor recognition between primary and recurrent disease. Methods: Tumor-associated lymphocytes (TAL) were expanded from primary and recurrent ascites samples using high-dose IL-2 and a rapid-expansion protocol (REP). Following expansion, TAL were assessed for recognition of autologous tumor by IFN-γ ELISPOT and flow cytometry for CD137. CD137+ tumor-reactive TAL were FACS-purified and the tumor-reactive T cell repertoire was profiled by deep sequencing of TCRβ chains (TCRseq). Tumor-reactive TCR clonotypes were compared between primary and recurrent disease to elucidate differences in tumor-reactive populations over time in HGSC. Results: Patient TAL recognized tumor in two out of three cases. In patient IROC 060, the tumor became more immunogenic between primary and recurrent disease, which may reflect expression of new antigens and/or loss of an immunosuppressive phenotype. In patient IROC 106, the tumor remained immunogenic between primary and recurrent disease, which may reflect maintenance of stable antigen expression and an immune-sensitive phenotype. Patient IROC 034 did not exhibit any tumor-reactivity, suggesting tumor-reactivity is not ubiquitous in HGSC. FACS-purification of CD137+ T cells followed by TCRseq was successfully performed on T cell populations of both high- and low-abundance, suggesting TCRseq can be performed on populations containing very few T cells. TCRseq results that profiled the clonal repertoire of tumor-reactive TAL from primary and recurrent disease in two patients, IROC 060 and IROC 106, showed both patients had evidence of T cell loss and T cell emergence between primary and recurrent disease. Further, IROC 106 had evidence of T cell clones that were maintained between primary and recurrent disease. Conclusions: Anti-tumor T cell responses from ascites are both diverse between patients and dynamic within a patient, suggesting various mechanisms of T cell evolution to contend with ITH in HGSC. I developed a pipeline for the identification of tumor-reactive TCR sequences without the need for a priori knowledge of specific antigens. Additionally, this pipeline is feasible for very low-abundance samples, such as tumor-reactive T cells. Significance: This study provides early insights into how TAL contend with ITH in HGSC. Ultimately, these results will inform the design of adoptive T cell therapy for recurrent HGSC. Advisors/Committee Members: Nelson, Brad H. (supervisor).

Subjects/Keywords: Cancer; Cancer Immunotherapy; Ovarian Cancer; Immunology; Immunotherapy

10 more images…

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Little, N. S. (2017). Investigating the co-evolution of tumor antigens and the anti-tumor immune response. (Masters Thesis). University of Victoria. Retrieved from https://dspace.library.uvic.ca//handle/1828/8503

Chicago Manual of Style (16^th Edition):

Little, Nicole S. “Investigating the co-evolution of tumor antigens and the anti-tumor immune response.” 2017. Masters Thesis, University of Victoria. Accessed March 31, 2020. https://dspace.library.uvic.ca//handle/1828/8503.

MLA Handbook (7^th Edition):

Little, Nicole S. “Investigating the co-evolution of tumor antigens and the anti-tumor immune response.” 2017. Web. 31 Mar 2020.

Vancouver:

Little NS. Investigating the co-evolution of tumor antigens and the anti-tumor immune response. [Internet] [Masters thesis]. University of Victoria; 2017. [cited 2020 Mar 31]. Available from: https://dspace.library.uvic.ca//handle/1828/8503.

Council of Science Editors:

Little NS. Investigating the co-evolution of tumor antigens and the anti-tumor immune response. [Masters Thesis]. University of Victoria; 2017. Available from: https://dspace.library.uvic.ca//handle/1828/8503

Cornell University

18. Sullivan, Kelly. Studies Of The Molecular Mechanisms Underlying Cancer Stem Cells And The Transformed Metabolic Phenotype .

Degree: 2015, Cornell University

URL: http://hdl.handle.net/1813/41119

► Intense research throughout recent decades has significantly expanded our knowledge of the complexities that make cancer a highly diverse and therapeutically challenging disease. Recently, cancer… (more)

▼ Intense research throughout recent decades has significantly expanded our knowledge of the complexities that make cancer a highly diverse and therapeutically challenging disease. Recently, cancer stem cells (CSCs) and de-regulated cellular metabolism have become appreciated for their crucial roles in the development, growth, and therapy resistance of tumors, and are now being pursued as therapeutic targets for the treatment of cancer. To better understand how these oncogenic events contribute to tumor malignancy, I carried out a mechanistic analysis of the CSC marker aldehyde dehydrogenase 1A3 (ALDH1A3) and the GTP-binding protein/crosslinking enzyme tissue transglutaminase (tTG), two proteins suspected to have key roles in tumor initiation and the development of the malignant state, in glioma stem cells (GSCs). Additionally, I examined the contributions of two isoforms of glutaminase (GLS), given the critical role of elevated glutamine metabolism in maintaining the transformed state. In delineating the role of ALDH1A3 in GSCs, I discovered that it is an important regulator of gene expression through the production of retinoic acid (RA). Specifically, I demonstrated that the expression of tTG is induced downstream of ALDH1A3 via RA in highly aggressive GSCs. Furthermore, targeting tTG results in a dramatic reduction in the self-renewal of these cells, suggesting that it may be a viable therapeutic target in ALDH1A3 + GSCs. Finally, I showed that combination therapies including a tTG inhibitor and radiation or chemotherapy are cytotoxic, indicating that tTG inhibitors enhance the effects of standard glioma therapies. Work described in this thesis has also been directed toward understanding the roles of different splice variants of the metabolic enzyme GLS in cancer cell growth. An important question in the field has concerned whether the two known GLS splice variants, glutaminase C (GAC) and kidney-type glutaminase (KGA), have redundant or opposing functions. This becomes especially relevant when considering the importance of targeting one or both of these enzymes when designing strategies to inhibit the metabolic reprogramming of cancer cells. Here, I show that although KGA is expressed at low levels in cancer cells relative to GAC, these isoforms are functionally redundant in their abilities to support the transformed metabolic phenotype. Advisors/Committee Members: Emr,Scott David (committeeMember), Linder,Maurine E. (committeeMember).

Subjects/Keywords: Cancer stem cells; Cancer metabolism; Cancer therapies

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sullivan, K. (2015). Studies Of The Molecular Mechanisms Underlying Cancer Stem Cells And The Transformed Metabolic Phenotype . (Thesis). Cornell University. Retrieved from http://hdl.handle.net/1813/41119

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sullivan, Kelly. “Studies Of The Molecular Mechanisms Underlying Cancer Stem Cells And The Transformed Metabolic Phenotype .” 2015. Thesis, Cornell University. Accessed March 31, 2020. http://hdl.handle.net/1813/41119.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sullivan, Kelly. “Studies Of The Molecular Mechanisms Underlying Cancer Stem Cells And The Transformed Metabolic Phenotype .” 2015. Web. 31 Mar 2020.

Vancouver:

Sullivan K. Studies Of The Molecular Mechanisms Underlying Cancer Stem Cells And The Transformed Metabolic Phenotype . [Internet] [Thesis]. Cornell University; 2015. [cited 2020 Mar 31]. Available from: http://hdl.handle.net/1813/41119.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sullivan K. Studies Of The Molecular Mechanisms Underlying Cancer Stem Cells And The Transformed Metabolic Phenotype . [Thesis]. Cornell University; 2015. Available from: http://hdl.handle.net/1813/41119

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

McMaster University

19. Yan, Judy. Characterizing prostate cancer stem-like cells and their contribution to prostate cancer tumorigenesis.

Degree: PhD, 2014, McMaster University

URL: http://hdl.handle.net/11375/16285

►

On average, 65 Canadian men will be diagnosed with prostate cancer (PC) every day, making it the most common male cancer in Canada. Despite the… (more)

▼

On average, 65 Canadian men will be diagnosed with prostate cancer (PC) every day, making it the most common male cancer in Canada. Despite the prevalence, the etiology of PC is unknown. Evidence nonetheless supports the role of prostate cancer stem cells (PCSCs) in PC initiation and metastasis. In spite of almost a decade worth of research on PCSCs our knowledge on their biology remains fragmented. By taking advantage of the availability of DU145 cell-derived PCSCs in our laboratory, this thesis research focuses on investigating the unique properties of PCSCs and their function in promoting PC tumorigenesis. We identified two PCSC-specific proteins, ALDH3A1 and CNTN1. In mouse models of xenograft tumors, ALDH3A1 was expressed at higher levels in PCSC-derived tumors than in DU145 non-PCSC-produced tumors and in lung metastases than local tumors. In clinical settings, elevation of ALDH3A1expression was observed from normal prostate tissues to carcinomas and from local PCs to the paired lymph node metastases. Additionally, ALDH3A1 was clearly detected in bone metastases. Similar to ALDH3A1, CNTN1 expression associates with PC progression and biochemical recurrence following radical prostatectomy. The clear presence of CNTN1 in lymph node and bone metastases was also demonstrated. Furthermore, CNTN1 expression promoted PC metastasis to the lungs and tumor initiation in NOD/SCID mice. Mechanistically, CNTN1 increased AKT activation and reduced E-cadherin expression. Collectively, our research revealed important roles of both PCSC proteins in promoting PC tumorigenesis and progression. PC develops chemotherapy resistance in which PCSCs play a major role. In supporting this knowledge, we demonstrated that PCSCs are innately more resistant to the chemotherapeutic drugs, etoposide and docetaxel and that this resistance was in part attributable to their enhanced DNA damage response. Taken together, the findings of this thesis advances our knowledge on two specific PCSC markers and their association with prostate cancer progression and metastasis. As well as to the mechanism whereby PCSCs promote resistance to chemotherapeutic drugs.

Thesis

Doctor of Philosophy (PhD)

Advisors/Committee Members: Tang, Damu, Medical Sciences.

Subjects/Keywords: Cancer; Cancer stem cells; Prostate Cancer

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Yan, J. (2014). Characterizing prostate cancer stem-like cells and their contribution to prostate cancer tumorigenesis. (Doctoral Dissertation). McMaster University. Retrieved from http://hdl.handle.net/11375/16285

Chicago Manual of Style (16^th Edition):

Yan, Judy. “Characterizing prostate cancer stem-like cells and their contribution to prostate cancer tumorigenesis.” 2014. Doctoral Dissertation, McMaster University. Accessed March 31, 2020. http://hdl.handle.net/11375/16285.

MLA Handbook (7^th Edition):

Yan, Judy. “Characterizing prostate cancer stem-like cells and their contribution to prostate cancer tumorigenesis.” 2014. Web. 31 Mar 2020.

Vancouver:

Yan J. Characterizing prostate cancer stem-like cells and their contribution to prostate cancer tumorigenesis. [Internet] [Doctoral dissertation]. McMaster University; 2014. [cited 2020 Mar 31]. Available from: http://hdl.handle.net/11375/16285.

Council of Science Editors:

Yan J. Characterizing prostate cancer stem-like cells and their contribution to prostate cancer tumorigenesis. [Doctoral Dissertation]. McMaster University; 2014. Available from: http://hdl.handle.net/11375/16285

Rutgers University

20. Hemler, Jennifer R., 1972-. Life with, after, or beyond cancer: breast cancer survivorship and the new normal.

Degree: PhD, Sociology, 2015, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/48509/

►

I examine how women “move on,” or are unable to, after a diagnosis of breast cancer. I interviewed 80 survivors of various types and stages… (more)

▼

I examine how women “move on,” or are unable to, after a diagnosis of breast cancer. I interviewed 80 survivors of various types and stages of breast cancer to explore the relationship between how breast cancer survivors think about cancer and how they manage the daily consequences of this disease, including its effects on identity. My main objective was to examine the cognitive strategies and social practices survivors employ for living with (a history of having had) cancer. Cancer experience is undoubtedly shaped by factors like disease stage and type, treatments received, time since diagnosis and treatment, age, and social location. But many of my participants, across categories, described bracketing some aspects of their experience while holding onto a certain degree of ontological insecurity as they redefined their lives after, with, or beyond cancer. Drawing on ontological insecurity enabled them to remain attuned to their selves: they used cancer to help them redraw boundaries in their lives and focus attention on their selves in ways they were not doing previously. While self-regulatory health practices, feminist ideologies/the women’s health movement, and environmental awareness overlap in breast cancer survivorship to produce activated patients and actualized subjectivities, my participants also discussed how the existential and medical uncertainties of their experiences led them to create new spaces for meaning in their lives. However, while many of my participants wanted to use cancer as a catalyst for self-growth or change across life domains, certainly not all of them were able to do so. Survivorship programs are critical in this regard. They can help survivors harness the uncertainty they feel instead of allowing it to become paralyzing or debilitating. Many survivors need help framing ontological insecurity as a resource to employ, not something to move beyond; but, moreover, they need spaces in which they can acknowledge these uncertainties as part of their new realities.

Advisors/Committee Members: Cerulo, Karen A (chair), Carr, Deborah (internal member), Horwitz, Allan (internal member), Almeling, Rene (outside member).

Subjects/Keywords: Breast – Cancer; Breast cancer patients; Cancer – Patients

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hemler, Jennifer R., 1. (2015). Life with, after, or beyond cancer: breast cancer survivorship and the new normal. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/48509/

Chicago Manual of Style (16^th Edition):

Hemler, Jennifer R., 1972-. “Life with, after, or beyond cancer: breast cancer survivorship and the new normal.” 2015. Doctoral Dissertation, Rutgers University. Accessed March 31, 2020. https://rucore.libraries.rutgers.edu/rutgers-lib/48509/.

MLA Handbook (7^th Edition):

Hemler, Jennifer R., 1972-. “Life with, after, or beyond cancer: breast cancer survivorship and the new normal.” 2015. Web. 31 Mar 2020.

Vancouver:

Hemler, Jennifer R. 1. Life with, after, or beyond cancer: breast cancer survivorship and the new normal. [Internet] [Doctoral dissertation]. Rutgers University; 2015. [cited 2020 Mar 31]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/48509/.

Council of Science Editors:

Hemler, Jennifer R. 1. Life with, after, or beyond cancer: breast cancer survivorship and the new normal. [Doctoral Dissertation]. Rutgers University; 2015. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/48509/

Rutgers University

21. Chen, Jayson Xiao-Chen, 1982-. Cancer preventive effects of tocopherols in dietary carcinogen-induced colon and prostate carcinogenesis models.

Degree: PhD, Toxicology, 2016, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/51247/

►

Colorectal and prostate cancers are leading causes of morbidity and mortality in the United States and worldwide. While immense progress has been made in reducing… (more)

▼

Colorectal and prostate cancers are leading causes of morbidity and mortality in the United States and worldwide. While immense progress has been made in reducing incidence and death of these cancers in the past few decades, they remain major public health issues, highlighting the need for better understanding, prevention and intervention of these diseases. One major strategy to address these issues is research into more relevant animal cancer models and potent chemopreventive agents. The purpose of this dissertation research was to characterize a novel colon carcinogenesis model induced by the meat-derived carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), with colitis from Dextran Sodium Sulfate (DSS) and determine the effects of different tocopherol forms of vitamin E on the colon carcinogenesis model as well as a PhIP-induced prostate carcinogenesis model. The rapid induction of PhIP/DSS-induced colon carcinogenesis in the CYP1A-humanized mice was determined to be caused by active Ctnnb1/Î²-catenin mutations in residual epithelial cells, which when promoted by colitis, developed into precancerous lesion, high-grade dysplasia, and finally adenocarcinoma. These features resembled human colitis-associated colon cancer. In the PhIP/DSS-induced colon carcinogenesis model, dietary supplementation with d-T and g-T, but not a-T, significantly attenuated colon tumor formation and inhibited oxidative and nitrosative stress as well as pro-inflammatory markers. Additional studies indicate the potent inhibitory effects of d-T and g-T was mainly due to protection against early cellular and DNA damage caused by the PhIP carcinogen. In the PhIP-induced prostate carcinogenesis model, dietary supplementation with g-TmT and d-T effectively reduced the formation and severity of mouse PIN lesions as well as p-Akt expression, whereas g-T and a-T were less effective. Further studies suggest the chemopreventive effects of the tocopherols involved the reduction in cellular oxidative and nitrosative stress and inhibition of the PI3K/Akt signaling pathway that regulate cell survival and proliferation. Together, the findings from this research demonstrate the relevance of PhIP dietary carcinogen-induced and DSS colitis-promoted colon carcinogenesis model and the superior cancer preventive activities of d-T and g-T compared to the classic a-T.

Advisors/Committee Members: yang, chung s (chair), Reuhl, Kenneth (internal member), Zarbl, Helmut (internal member), Suh, Nanjoo (internal member), Verzi, Michael (outside member).

Subjects/Keywords: Cancer – Prevention; Colon (Anatomy) – Cancer; Prostate – Cancer

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chen, Jayson Xiao-Chen, 1. (2016). Cancer preventive effects of tocopherols in dietary carcinogen-induced colon and prostate carcinogenesis models. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/51247/

Chicago Manual of Style (16^th Edition):

Chen, Jayson Xiao-Chen, 1982-. “Cancer preventive effects of tocopherols in dietary carcinogen-induced colon and prostate carcinogenesis models.” 2016. Doctoral Dissertation, Rutgers University. Accessed March 31, 2020. https://rucore.libraries.rutgers.edu/rutgers-lib/51247/.

MLA Handbook (7^th Edition):

Chen, Jayson Xiao-Chen, 1982-. “Cancer preventive effects of tocopherols in dietary carcinogen-induced colon and prostate carcinogenesis models.” 2016. Web. 31 Mar 2020.

Vancouver:

Chen, Jayson Xiao-Chen 1. Cancer preventive effects of tocopherols in dietary carcinogen-induced colon and prostate carcinogenesis models. [Internet] [Doctoral dissertation]. Rutgers University; 2016. [cited 2020 Mar 31]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/51247/.

Council of Science Editors:

Chen, Jayson Xiao-Chen 1. Cancer preventive effects of tocopherols in dietary carcinogen-induced colon and prostate carcinogenesis models. [Doctoral Dissertation]. Rutgers University; 2016. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/51247/

University of the Western Cape

22. Fadaka, Adewale Oluwaseun. MicroRNAs as predictive biomarkers for diagnosis and prognosis of colorectal cancer using in silico approaches .

Degree: 2019, University of the Western Cape

URL: http://hdl.handle.net/11394/7161

► Colorectal cancer (CRC) is referred to as cancers that arise in the colon or rectum. Rectal cancer is most often defined as cancers originating within… (more)

Subjects/Keywords: Colorectal cancer; Cancer biomarkers; Cancer; Early detection

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Fadaka, A. O. (2019). MicroRNAs as predictive biomarkers for diagnosis and prognosis of colorectal cancer using in silico approaches . (Thesis). University of the Western Cape. Retrieved from http://hdl.handle.net/11394/7161

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Fadaka, Adewale Oluwaseun. “MicroRNAs as predictive biomarkers for diagnosis and prognosis of colorectal cancer using in silico approaches .” 2019. Thesis, University of the Western Cape. Accessed March 31, 2020. http://hdl.handle.net/11394/7161.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Fadaka, Adewale Oluwaseun. “MicroRNAs as predictive biomarkers for diagnosis and prognosis of colorectal cancer using in silico approaches .” 2019. Web. 31 Mar 2020.

Vancouver:

Fadaka AO. MicroRNAs as predictive biomarkers for diagnosis and prognosis of colorectal cancer using in silico approaches . [Internet] [Thesis]. University of the Western Cape; 2019. [cited 2020 Mar 31]. Available from: http://hdl.handle.net/11394/7161.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Fadaka AO. MicroRNAs as predictive biomarkers for diagnosis and prognosis of colorectal cancer using in silico approaches . [Thesis]. University of the Western Cape; 2019. Available from: http://hdl.handle.net/11394/7161

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Alberta

23. Khan, Mohammad KA. Population-based evaluation of disparities in survival of lung cancer patients in Alberta, Canada.

Degree: MS, Department of Public Health Sciences, 2014, University of Alberta

URL: https://era.library.ualberta.ca/files/b2773x008

► Lung cancer patients of Alberta have lower relative survival compared to their counterparts in Manitoba, British Columbia and Ontario. We conducted two population-based cancer mortality… (more)

Subjects/Keywords: Cancer Epidemiology/ Cancer Biostatistics

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Khan, M. K. (2014). Population-based evaluation of disparities in survival of lung cancer patients in Alberta, Canada. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/b2773x008

Chicago Manual of Style (16^th Edition):

Khan, Mohammad KA. “Population-based evaluation of disparities in survival of lung cancer patients in Alberta, Canada.” 2014. Masters Thesis, University of Alberta. Accessed March 31, 2020. https://era.library.ualberta.ca/files/b2773x008.

MLA Handbook (7^th Edition):

Khan, Mohammad KA. “Population-based evaluation of disparities in survival of lung cancer patients in Alberta, Canada.” 2014. Web. 31 Mar 2020.

Vancouver:

Khan MK. Population-based evaluation of disparities in survival of lung cancer patients in Alberta, Canada. [Internet] [Masters thesis]. University of Alberta; 2014. [cited 2020 Mar 31]. Available from: https://era.library.ualberta.ca/files/b2773x008.

Council of Science Editors:

Khan MK. Population-based evaluation of disparities in survival of lung cancer patients in Alberta, Canada. [Masters Thesis]. University of Alberta; 2014. Available from: https://era.library.ualberta.ca/files/b2773x008

Texas A&M University

24. Kotha, Leela. Inhibition of breast and prostate cancer cell growth by 3,3'-diindolylmethane and related compounds.

Degree: 2009, Texas A&M University

URL: http://hdl.handle.net/1969.1/ETD-TAMU-1121

► Selective receptor modulators have been developed for steroid hormone receptors as a new class of mechanism-based drugs for treatment of hormone related diseases. We investigated… (more)

▼ Selective receptor modulators have been developed for steroid hormone receptors as a new class of mechanism-based drugs for treatment of hormone related diseases. We investigated an alternative mechanism-based strategy for treating various cancers with selective aryl hydrocarbon receptor modulators (SAhRMs), such as diindolylmetane/(DIM), 2,3,7,8-tetrachlorodibenzo-pdioxin/( TCDD), and 6-6-methyl-1,3,8-trichlorodibenzofuran/(MCDF) that exhibit antiproliferative activity in several cancer cell lines. MDA-MB-453 and BT-474 are estrogen receptor/(ER) negative breast cancer cell lines that express a functional aryl hydrocarbon receptor/(AhR) and treatment with SAhRMs significantly inhibited MDA-MB-453/BT-474 cell proliferation but did not significantly affect the percent distribution of cells in G0/G1/S/G2/M phases of cell cycle. TCDD and the SAhRMs had minimal effects on the expression of various cellular kinases. These data coupled with results obtained for other activated kinase pathways demonstrate that TCDD and SAhRMs uniquely inhibit growth of ER-negative MDA-MB 453/BT-474 breast cancer cells through kinase independent pathways. However, the SAhRMs induced HES-1, an antiproliferative transcription factor, in both cell lines and this might represent a possible mechanism for the growth inhibitory effects observed with these compounds. We proved that ring substituted DIMs exhibit androgenic/antiandrogenic activities in androgen receptor/(AR)-positive LNCaP/22RV1 prostate cancer cell lines resulting in antiproliferative activities. These antiproliferative activities were accompanied by antiandrogenic activity and structure-dependent down regulation of AR. The ring-substituted DIMs also induced both non-steroidal anti-inflamatory drug-induced gene-1/(NAG-1) and activating transcription factor 3/(ATF-3), two anti-proliferative/apoptotic genes which are responsible in part for the inhibitory effects of these compounds on the proliferation of prostate cancer cells. Advisors/Committee Members: Safe, Stephen (advisor), Burghardt, Robert (committee member), Chowdhary, Bhanu (committee member), Phillips, Timothy (committee member).

Subjects/Keywords: BREAST CANCER; PROSTATE CANCER

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kotha, L. (2009). Inhibition of breast and prostate cancer cell growth by 3,3'-diindolylmethane and related compounds. (Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/ETD-TAMU-1121

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kotha, Leela. “Inhibition of breast and prostate cancer cell growth by 3,3'-diindolylmethane and related compounds.” 2009. Thesis, Texas A&M University. Accessed March 31, 2020. http://hdl.handle.net/1969.1/ETD-TAMU-1121.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kotha, Leela. “Inhibition of breast and prostate cancer cell growth by 3,3'-diindolylmethane and related compounds.” 2009. Web. 31 Mar 2020.

Vancouver:

Kotha L. Inhibition of breast and prostate cancer cell growth by 3,3'-diindolylmethane and related compounds. [Internet] [Thesis]. Texas A&M University; 2009. [cited 2020 Mar 31]. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-1121.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kotha L. Inhibition of breast and prostate cancer cell growth by 3,3'-diindolylmethane and related compounds. [Thesis]. Texas A&M University; 2009. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-1121

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Nelson Mandela Metropolitan University

25. Knoetze, Steyn. The development of novel cancer targeting agents.

Degree: Faculty of Science, 2011, Nelson Mandela Metropolitan University

URL: http://hdl.handle.net/10948/d1010636

► The search for the cure for cancer is currently a multi-billion dollar industry and the search for the elusive “magic bullet”, i.e. the perfect cancer… (more)

▼ The search for the cure for cancer is currently a multi-billion dollar industry and the search for the elusive “magic bullet”, i.e. the perfect cancer drug that would interact therapeutically with cancerous tissues while having a minimal effect on healthy cells, is the topic of many research studies in the world today. A large number of novel drugs or drug complexes and conjugates are being synthesized and subjected to rigorous evaluation in the race to find the perfect cure. ECDG (Ethylene diCysteine DeoxyGlucose) seems to have promising cancer targeting ability. Even though this compound has been described in a few publications, we could not find any reference to the current use of ECDG in oncology clinics, either as a therapeutic agent, or as a diagnostic tool for imaging purposes. It was also not possible to purchase pure ECDG anywhere in the world. This prompted us to further investigate ECDG as a possible candidate for cancer targeting research, either as an imaging agent for cancer diagnosis or complexed with an anti-cancer agent for therapeutic purposes. Detailed investigations done in our laboratory can be divided into the following categories: - Development of a synthetic method for ECDG on a multigram scale ; - Purification of prepared ECDG not using the described dialysis method that only allows the purification of small quantities of ECDG (mg scale) ; Detailed investigation of the chemistry involved in the preparation of pure ECDG and its metal complexes ; - Investigation of the stability of ECDG and its metal complexes that is essential data required for any pharmaceutical agent ; - Preparation of ECDG complexes for use as a diagnostic tool, i.e. complexation with 99mTc ; Investigation of the bio distribution of ECDG-ReO complexes ; - Preparation of an ECDG kit as a diagnostic tool for use in oncology clinics. The development of novel aromatic ligands having similar characteristics compared to ECDG, containing an N2S2 chromophore as donor atoms, to further investigate their targeting capabilities, have also been investigated. All intermediates and final compounds were characterized mainly by ESI MS, in some cases IR and NMR whenever available. Successful preparation and purification of ECDG ands its metal complexes was achieved and extensively characterized and evaluated. Efforts directed towards the development of ECDG at NECSA, South Africa, were also rewarded with significant success. Furthermore, significant development regarding the synthesis of two novel compounds with ECDG-like characteristics was also completed.

Subjects/Keywords: Cancer – Research; Cancer – Treatment

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Knoetze, S. (2011). The development of novel cancer targeting agents. (Thesis). Nelson Mandela Metropolitan University. Retrieved from http://hdl.handle.net/10948/d1010636

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Knoetze, Steyn. “The development of novel cancer targeting agents.” 2011. Thesis, Nelson Mandela Metropolitan University. Accessed March 31, 2020. http://hdl.handle.net/10948/d1010636.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Knoetze, Steyn. “The development of novel cancer targeting agents.” 2011. Web. 31 Mar 2020.

Vancouver:

Knoetze S. The development of novel cancer targeting agents. [Internet] [Thesis]. Nelson Mandela Metropolitan University; 2011. [cited 2020 Mar 31]. Available from: http://hdl.handle.net/10948/d1010636.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Knoetze S. The development of novel cancer targeting agents. [Thesis]. Nelson Mandela Metropolitan University; 2011. Available from: http://hdl.handle.net/10948/d1010636

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Hong Kong

26. Li, Siyue. Novel theranostics based on hybrid nanoparticles for early cancer detection and treatment.

Degree: PhD, 2013, University of Hong Kong

URL: Li, S. [李思越]. (2013). Novel theranostics based on hybrid nanoparticles for early cancer detection and treatment. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5153667 ; http://dx.doi.org/10.5353/th_b5153667 ; http://hdl.handle.net/10722/207163

► Nanoscience and nanotechnology have advanced rapidly in recent years and have made a profound impact in the medical field. Nanoparticles have attracted great attention for… (more)

▼ Nanoscience and nanotechnology have advanced rapidly in recent years and have made a profound impact in the medical field. Nanoparticles have attracted great attention for their potential as diagnostic and/or therapeutic tools in oncology owing to their unique properties. Theranostics are nanodevices with diagnostic, therapeutic and possibly treatment-monitoring functions for treating cancers. Different noble metal nanoparticles can provide the basic unit for theranostics. Suitably designed and developed noble metal nanoparticle-based theranostics will have multiple functions. In this project, the design, fabrication and performance of novel multifunctional nanodevices for cancer detection and treatment were investigated. The foundation of this project was laid by investigating different types of hybrid nanoparticles for novel theranostics. Different approaches were developed for fabricating core-shell structured hybrid nanoparticles. Highly branched gold and gold-silver bimetallic nanoparticles were firstly made. pH-sensitive folic acid-chitosan (CS-FA) conjugate was then introduced on these nanoparticles to form hybrid nanoparticles with a metal core ([email protected] and [email protected]). Poly(lactide-co-glycolide) (PLGA) and chitosan (CS) micro- or nanoparticles were also produced to serve as the polymer core for forming hybrid particles with a gold or gold-silver nanoshell ([email protected], [email protected] and [email protected]). Furthermore, [email protected] nanoparticles having both magnetic and plasmonic properties were investigated. Thermo-sensitive poly(N-isopropylacrylamide) (pNIPAm) polymer or pH-sensitive CS-FA was then coated on [email protected] nanoparticles, forming new hybrid nanoparticles. The formation mechanisms of nanoparticles and hybrid nanoparticles were studied. Raman reporters (Rhodamine B or 4-mercaptobenzoic acid) and anti-cancer drugs (paclitaxel or 5-fluorouracil) were loaded into the polymer core or shell of hybrid nanoparticles to form multifunctional nanodevices. While the noble metal unit in the nanodevices provided high light-scattering enhancement for achieving photothermal effect, the polymer component encapsulated Raman reporter molecules and put them close to the metal nanoparticles for generating high surface enhanced Raman scattering (SERS) signals. These nanodevices could also serve as excellent drug carriers, and the stimulus-triggered release of incorporated drug was studied. It was shown in this project that the conjugation of targeting ligand (e.g. folic acid) or antibody (e.g. anti-HER2 monoclonal antibody) on hybrid nanoparticles had formed novel theranostics which allowed selective detection, continuous imaging of intracellular behavior and killing of targeted cancer cells. These theranostics could be taken up by specific cancer cells through receptor-mediated endocytosis and internalized into cytoplasma of the cell. These theranostics as stable SERS-active tags and imaging agents for HeLa cells, SK-BR-3 cancer cells or MCF-7 cancer cells were demonstrated. The targeting ability and intracellular uptake of these…

Subjects/Keywords: Nanomedicine; Cancer - Treatment; Cancer - Diagnosis

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Li, S. (2013). Novel theranostics based on hybrid nanoparticles for early cancer detection and treatment. (Doctoral Dissertation). University of Hong Kong. Retrieved from Li, S. [李思越]. (2013). Novel theranostics based on hybrid nanoparticles for early cancer detection and treatment. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5153667 ; http://dx.doi.org/10.5353/th_b5153667 ; http://hdl.handle.net/10722/207163

Chicago Manual of Style (16^th Edition):

Li, Siyue. “Novel theranostics based on hybrid nanoparticles for early cancer detection and treatment.” 2013. Doctoral Dissertation, University of Hong Kong. Accessed March 31, 2020. Li, S. [李思越]. (2013). Novel theranostics based on hybrid nanoparticles for early cancer detection and treatment. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5153667 ; http://dx.doi.org/10.5353/th_b5153667 ; http://hdl.handle.net/10722/207163.

MLA Handbook (7^th Edition):

Li, Siyue. “Novel theranostics based on hybrid nanoparticles for early cancer detection and treatment.” 2013. Web. 31 Mar 2020.

Vancouver:

Li S. Novel theranostics based on hybrid nanoparticles for early cancer detection and treatment. [Internet] [Doctoral dissertation]. University of Hong Kong; 2013. [cited 2020 Mar 31]. Available from: Li, S. [李思越]. (2013). Novel theranostics based on hybrid nanoparticles for early cancer detection and treatment. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5153667 ; http://dx.doi.org/10.5353/th_b5153667 ; http://hdl.handle.net/10722/207163.

Council of Science Editors:

Li S. Novel theranostics based on hybrid nanoparticles for early cancer detection and treatment. [Doctoral Dissertation]. University of Hong Kong; 2013. Available from: Li, S. [李思越]. (2013). Novel theranostics based on hybrid nanoparticles for early cancer detection and treatment. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5153667 ; http://dx.doi.org/10.5353/th_b5153667 ; http://hdl.handle.net/10722/207163

Anna University

27. Venkataraman D. Analysis of glandular cells in Sputum cytology images for lung Cancer detection;.

Degree: Analysis of glandular cells in Sputum cytology images for lung Cancer detection, 2015, Anna University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/39226

►

One of the biggest challenges the world face today is the mortality newlinedue to Cancer One in four of all diagnosed cancers involve the lung… (more)

Subjects/Keywords: Adenocarcinoma cancer; Cancer detection

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

D, V. (2015). Analysis of glandular cells in Sputum cytology images for lung Cancer detection;. (Thesis). Anna University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/39226

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

D, Venkataraman. “Analysis of glandular cells in Sputum cytology images for lung Cancer detection;.” 2015. Thesis, Anna University. Accessed March 31, 2020. http://shodhganga.inflibnet.ac.in/handle/10603/39226.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

D, Venkataraman. “Analysis of glandular cells in Sputum cytology images for lung Cancer detection;.” 2015. Web. 31 Mar 2020.

Vancouver:

D V. Analysis of glandular cells in Sputum cytology images for lung Cancer detection;. [Internet] [Thesis]. Anna University; 2015. [cited 2020 Mar 31]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/39226.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

D V. Analysis of glandular cells in Sputum cytology images for lung Cancer detection;. [Thesis]. Anna University; 2015. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/39226

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Missouri – Columbia

28. Suresh, Dhananjay. Cubic and spherical nanoparticles for detection and therapy of cancer.

Degree: 2016, University of Missouri – Columbia

URL: http://hdl.handle.net/10355/62484

► Cancer is the leading cause of high mortality rates. Cancer patients require advanced treatment due to lack of early prevention and diagnosis. Moreover, progression of… (more)

▼ Cancer is the leading cause of high mortality rates. Cancer patients require advanced treatment due to lack of early prevention and diagnosis. Moreover, progression of the disease is unpredictable and personalized therapy options are being explored. Existing cancer therapy leads to drug resistance that worsens patient survival rates, and thus disease management is challenging. This necessitates the need to understand the underlying cause, early detection of possible biomarkers, monitor the disease state and develop effective therapeutics. Current innovations in cancer detection and therapy includes use of newer class of smart nanomaterials. These advances in nanoscale materials, due to their unique size, chemical and physical properties, make them ideal for nanomedicinal and nanoelectronic applications. The work performed in this thesis describes the design and the synthesis of cubic and spherical nanoparticles, and their subsequent applications toward energy interactions, biochemical interactions and cellular targeting. Details of receptor mediated endocytic mechanism, targeted capture of circulating tumor cells (CTC), athermal mechanism of controlled release of biomolecules from nanoparticles using femtosecond pulses, and targeted siRNA delivery using nanoparticles have been explained. Mechanistic studies showed that receptor targeting follows a clathrin mediated endocytic pathway. Receptor-targeted nanoparticles showed effective capture of EpCAM-negative CTCs. The cubic shaped nanoparticles were found to enhance the plasmon-photon coupling to efficiently release biomolecules. Spherical nanoparticle mediated siRNA delivery resensitized drug resistant NSCLC by downregulating two important oncogenes, AXL and FN14 as observed by both in vitro and in vivo studies. Additionally, the study highlights drug resensitization following the effective knockdown of AXL using CRISPR based gene editing. Overall, the results demonstrate the application of nanoparticles for advanced diagnostics and therapeutics. Advisors/Committee Members: Kannan, Raghuraman (advisor).

Subjects/Keywords: Cancer – Treatment; Cancer – Diagnosis; Nanoparticles

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Suresh, D. (2016). Cubic and spherical nanoparticles for detection and therapy of cancer. (Thesis). University of Missouri – Columbia. Retrieved from http://hdl.handle.net/10355/62484

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Suresh, Dhananjay. “Cubic and spherical nanoparticles for detection and therapy of cancer.” 2016. Thesis, University of Missouri – Columbia. Accessed March 31, 2020. http://hdl.handle.net/10355/62484.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Suresh, Dhananjay. “Cubic and spherical nanoparticles for detection and therapy of cancer.” 2016. Web. 31 Mar 2020.

Vancouver:

Suresh D. Cubic and spherical nanoparticles for detection and therapy of cancer. [Internet] [Thesis]. University of Missouri – Columbia; 2016. [cited 2020 Mar 31]. Available from: http://hdl.handle.net/10355/62484.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Suresh D. Cubic and spherical nanoparticles for detection and therapy of cancer. [Thesis]. University of Missouri – Columbia; 2016. Available from: http://hdl.handle.net/10355/62484

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Addis Ababa University

29. Atsednesh, Getachew. Psychosocial Impact of Childhood Cancer on Parents with Children Diagnosed with Cancer: The Case of Parents Receiving Service at Tikur Anbessa Specialized Hospital .

Degree: 2014, Addis Ababa University

URL: http://etd.aau.edu.et/dspace/handle/123456789/5483

► Cancer, one of the non-communicable diseases is gaining momentum in Ethiopia. As the country has only one cancer treatment center for both adults and children,… (more)

Subjects/Keywords: Childhood Cancer; Cancer Treatment

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Atsednesh, G. (2014). Psychosocial Impact of Childhood Cancer on Parents with Children Diagnosed with Cancer: The Case of Parents Receiving Service at Tikur Anbessa Specialized Hospital . (Thesis). Addis Ababa University. Retrieved from http://etd.aau.edu.et/dspace/handle/123456789/5483

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Atsednesh, Getachew. “Psychosocial Impact of Childhood Cancer on Parents with Children Diagnosed with Cancer: The Case of Parents Receiving Service at Tikur Anbessa Specialized Hospital .” 2014. Thesis, Addis Ababa University. Accessed March 31, 2020. http://etd.aau.edu.et/dspace/handle/123456789/5483.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Atsednesh, Getachew. “Psychosocial Impact of Childhood Cancer on Parents with Children Diagnosed with Cancer: The Case of Parents Receiving Service at Tikur Anbessa Specialized Hospital .” 2014. Web. 31 Mar 2020.

Vancouver:

Atsednesh G. Psychosocial Impact of Childhood Cancer on Parents with Children Diagnosed with Cancer: The Case of Parents Receiving Service at Tikur Anbessa Specialized Hospital . [Internet] [Thesis]. Addis Ababa University; 2014. [cited 2020 Mar 31]. Available from: http://etd.aau.edu.et/dspace/handle/123456789/5483.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Atsednesh G. Psychosocial Impact of Childhood Cancer on Parents with Children Diagnosed with Cancer: The Case of Parents Receiving Service at Tikur Anbessa Specialized Hospital . [Thesis]. Addis Ababa University; 2014. Available from: http://etd.aau.edu.et/dspace/handle/123456789/5483

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Helsinki

30. Gylfe, Alexandra. New insights into the genetic basis of colorectal cancer.

Degree: Haartman Institute, Faculty of Medicine, Department of Medical Genetics; Research Programs Unit, Genome-Scale Biology Research Program, 2014, University of Helsinki

URL: http://hdl.handle.net/10138/44717

► Colorectal cancer (CRC) is the third most common cancer, and the second most common cause of cancer mortality. The aim of this thesis work was… (more)

▼ Colorectal cancer (CRC) is the third most common cancer, and the second most common cause of cancer mortality. The aim of this thesis work was to gain novel insight into the molecular mechanisms behind CRC predisposition, as well as tumor progression and development. Microsatellite instability (MSI) arises due to a defective mismatch repair system and is characteristic for a subset of all CRCs. Here, we aimed to identify novel MSI target genes with potential oncogenic effects. We characterized all genes overexpressed in MSI CRCs and predicted to escape nonsense-mediated decay when mutated. The mitotic checkpoint kinase TTK was identified with protein-elongating mutations in 59% of MSI CRCs. TTK has an essential role in spindle assembly checkpoint (SAC) signaling, however, the mutated protein did not show SAC weakening. While no evidence of oncogenic mechanisms was observed, the high mutation frequency of TTK argues for biological significance. In another screening effort on MSI CRCs, we sought to identify novel oncogenes with activating hotspot mutations. The exomes of 25 tumor and respective healthy colon tissues were sequenced. A total of 15 candidate oncogenes with hotspot mutations were identified. Three genes, ZBTB2, PSRC1 and RANBP2, displayed hotspot mutations also in the validation set of 86 MSI CRCs. Interestingly, the CRC-associated mutant form of ZBTB2 increased cell proliferation. Additional work is needed to further clarify the role of the identified somatic mutations in CRC tumorigenesis. The candidate oncogenes identified in this thesis work might be used to develop personalized tumor profiling and therapy. Inherited susceptibility is estimated to be involved in approximately one-third of all CRCs. However, the great majority of inherited CRC susceptibility remains still molecularly unexplained. A recent systematic sequencing study on CRC reported a set of somatically mutated genes, termed candidate cancer (CAN) genes. We examined the mutational profiles of 15 top-ranked CAN genes for somatic mutations as well as for germline variants in 45 familial CRC cases. In our tumor set, six of the CAN genes were somatically mutated. In germline, three private missense variants were identified in CSMD3, EPHB6 and c10orf137. In another effort, we exome sequenced 96 independent cases with familial CRC. We identified 11 novel candidate CRC susceptibility genes with rare putative LoF variants. Seven loss-of-heterozygosity events, involving four genes, were observed in the data. In each occasion, the losses targeted the wild-type allele (P=0.0078), providing further support that true culprits are among the eleven genes. This study provides an interesting set of candidate predisposing genes, which might explain a subset of common familial CRC. The identified germline variants need to be validated in larger sample sets to provide firm evidence for disease predisposition. Additional work is also needed to characterize the detailed functional and clinical relevance of the identified candidate CRC predisposing genes.…

Subjects/Keywords: cancer Genetics; cancer Genetics

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gylfe, A. (2014). New insights into the genetic basis of colorectal cancer. (Doctoral Dissertation). University of Helsinki. Retrieved from http://hdl.handle.net/10138/44717

Chicago Manual of Style (16^th Edition):

Gylfe, Alexandra. “New insights into the genetic basis of colorectal cancer.” 2014. Doctoral Dissertation, University of Helsinki. Accessed March 31, 2020. http://hdl.handle.net/10138/44717.

MLA Handbook (7^th Edition):

Gylfe, Alexandra. “New insights into the genetic basis of colorectal cancer.” 2014. Web. 31 Mar 2020.

Vancouver:

Gylfe A. New insights into the genetic basis of colorectal cancer. [Internet] [Doctoral dissertation]. University of Helsinki; 2014. [cited 2020 Mar 31]. Available from: http://hdl.handle.net/10138/44717.

Council of Science Editors:

Gylfe A. New insights into the genetic basis of colorectal cancer. [Doctoral Dissertation]. University of Helsinki; 2014. Available from: http://hdl.handle.net/10138/44717

Open Access Theses and Dissertations