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You searched for subject:(bromotyrosine derivative). One record found.

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NSYSU

1. Kao, Yu-Chen. Study the effects of Dibromotyrosine Derivative in TGF-β responsiveness.

Degree: Master, Biological Sciences, 2017, NSYSU

The Transforming growth factor β1 (TGF-β1) is belong to transforming growth factor superfamily. Many tumor lesions process are related to TGF-β1, such as: cell proliferation, extracellular matrix secretion, cell attachment, movement, differentiation and apoptosis. TGF-β1 cell signaling via two protein receptors on membrane which are Type I TGF-β receptor (TβR-I) and Type II TGF-β receptor (TβR-II). TGF-β is activated that lead smad2/3 to phosphorylation, and p-Smad2/3 will transfer to nuclear than regulates the transcription of the target gene with other transcription factor. At cancer early stage, TGF-β will use inhibit cell proliferation and promote cell apoptosis to inhibit cancer growth, but at cancer late stage,instead, TGF-β will promote cancer cell growth, invasion, transfer and help it to escape the immune system attack. There are some small molecule inhibitors which can inhibit TGF-β cell signal transduction have great value at cancer research. Small molecule inhibitor is a powerful tool in research of signal transduction pathway interaction. In this study, we found (1â²R,5â²S,6â²S)-2-(3â²,5â²- dibromo-1â²,6â²-dihydroxy-4â²-oxocyclohex-2â²-enyl) acetonitrile (DT), a bromotyrosine derivate from Pseudoceratina sp., which inhibits the TβR-I serine/threonine kinase then inhibits TGF-β downstream cell signaling. We use such as: luciferase activity assay, western blotting, wound healing assay, in vitro ALK5 kinase assay etc. to know the effect of DT on TGF-β cell signaling, and use epithelial cells to study of the inhibitory effects of DT on TGF-β-induced Smad signaling and epithelial-to-mesenchymal transition. We also confirmed the new ALK5 inhibitor can effectively inhibit TGF-β stimulate smad2/3 to phosphorylation and inhibit smad2/3 transfer to nuclear. In addition, DT also can inhibit TGF-β stimulate epithelial-to-mesenchymal transition and A549 cell metastasis. Our study showed DT can apply to treatment of fibrotic diseases and cancer in the future. Advisors/Committee Members: Wu, Chang-Yi (chair), Chien-Chih Chiu (chair), Wen Zhi-Hong (chair), (Chen, Chun-Lin (committee member).

Subjects/Keywords: TGF-β; bromotyrosine derivative; small molecular inhibitors; epithelial-to-mesenchymal transition

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APA (6th Edition):

Kao, Y. (2017). Study the effects of Dibromotyrosine Derivative in TGF-β responsiveness. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0718117-194840

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Kao, Yu-Chen. “Study the effects of Dibromotyrosine Derivative in TGF-β responsiveness.” 2017. Thesis, NSYSU. Accessed April 15, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0718117-194840.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Kao, Yu-Chen. “Study the effects of Dibromotyrosine Derivative in TGF-β responsiveness.” 2017. Web. 15 Apr 2021.

Vancouver:

Kao Y. Study the effects of Dibromotyrosine Derivative in TGF-β responsiveness. [Internet] [Thesis]. NSYSU; 2017. [cited 2021 Apr 15]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0718117-194840.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kao Y. Study the effects of Dibromotyrosine Derivative in TGF-β responsiveness. [Thesis]. NSYSU; 2017. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0718117-194840

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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