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Vanderbilt University
1.
Kumar, Ankur N.
Quantifying in vivo motion in video sequences using image registration.
Degree: PhD, Electrical Engineering, 2014, Vanderbilt University
URL: http://hdl.handle.net/1803/14690 
► Image registration is a pivotal part of many medical imaging analysis systems that provide clinically relevant medical information. One fundamental problem addressed by image registration…
(more)
▼ Image registration is a pivotal part of many medical imaging analysis systems that provide clinically relevant medical information. One fundamental problem addressed by image registration is the accounting of a subject’s motion. This dissertation broadly addresses the problem of quantifying in vivo motion in video sequences for two different applications using image registration. The first problem involves the correction of motion in in vivo time-series microscopy imaging of islets of Langerhans in mice. The second problem focuses on delivering near real-time 3D intraoperative movements of the cortical surface to a computational biomechanical model framework for the compensation of
brain shift during
brain tumor surgery. For the first application, a fully automatic algorithm is developed for the correction of in vivo time-series microscopy images of islets of Langerhans. The second application focuses on delivering near real-time 3D intraoperative movements of the cortical surface to a computational biomechanical model framework for the compensation of
brain shift during
brain tumor surgery. This dissertation demonstrates a clinical microscope-based digitization platform capable of reliably providing temporally dense 3D textured point clouds in near real-time of the FOV for the entire duration and under realistic conditions of neurosurgery. A fully automatic technique has been developed for robustly digitizing 3D points intraoperatively using an operating microscope at 1Hz. Another algorithm has been developed for tracking points on the cortical surface intraoperatively, which can potentially deliver intraoperative 3D displacements of the cortical surface at different time points during
brain tumor surgery.
Advisors/Committee Members: Dr. Michael Miga (committee member), Dr. Reid Thompson (committee member), Dr. Alan Peters (committee member), Dr. Bobby Bodenheimer (committee member), Dr. Dave Piston (committee member), Dr. Benoit Dawant (Committee Chair).
Subjects/Keywords: stereovision; image registration; in vivo; brain tumor surgery; image guided surgery; magnification
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APA (6th Edition):
Kumar, A. N. (2014). Quantifying in vivo motion in video sequences using image registration. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/14690
Chicago Manual of Style (16th Edition):
Kumar, Ankur N. “Quantifying in vivo motion in video sequences using image registration.” 2014. Doctoral Dissertation, Vanderbilt University. Accessed January 18, 2021.
http://hdl.handle.net/1803/14690.
MLA Handbook (7th Edition):
Kumar, Ankur N. “Quantifying in vivo motion in video sequences using image registration.” 2014. Web. 18 Jan 2021.
Vancouver:
Kumar AN. Quantifying in vivo motion in video sequences using image registration. [Internet] [Doctoral dissertation]. Vanderbilt University; 2014. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/1803/14690.
Council of Science Editors:
Kumar AN. Quantifying in vivo motion in video sequences using image registration. [Doctoral Dissertation]. Vanderbilt University; 2014. Available from: http://hdl.handle.net/1803/14690
Freie Universität Berlin
2.
Schulz, Juliane.
validity, influence on the surgical strategie and prognostic value.
Degree: 2015, Freie Universität Berlin
URL: http://dx.doi.org/10.17169/refubium-13314
► 1.1 INTRODUCTION The resection of a brain tumor, located near or within functional structures is a very delicate procedure. It is necessary to find a…
(more)
▼ 1.1 INTRODUCTION The resection of a
brain tumor, located near or within
functional structures is a very delicate procedure. It is necessary to find a
balance between the preservation of functional tissue and complete
tumor
resection. The exact knowledge of the functional cortical topography
preoperatively is a prerequisite to give the patient good counsel about the
risks and chances of the
surgery. It is the aim of this dissertation to
evaluate the reliability, influence on the treatment strategy and correlation
of neurophysiological parameters with pre- and postsurgical motor status of
the patients, of navigated transcranial
Brain stimulation (NBS). 1.2 METHODS
With NBS spatially very precise stimulation impulses are transmitted
transcranially by an electromagnetic coil onto the cortex. Since October 2007
the
tumor hemisphere and healthy hemisphere were mapped of all patients with
brain tumors in or near the motor cortex. Patient characteristics, clinical
data, NBS results and the influence of NBS on the treatment strategy were
collected prospectively in a database. A consistency study, an analysis of
neurophysiological data and studies about the influence of NBS on surgical
planning and treatment outcome were based on this data. 1.3 RESULTS The study
showed in over 25% of the cases a significant influence of NBS on the
treatment strategy of
brain tumor operations. Additionally, surgeons described
in 50% of the cases a subjective benefit for the surgical planning. For the
first time a significant difference of RMT and MEP data between both
hemispheres of
tumor patients in contrast to healthy subjects could be
documented. There was no significant distance of CoGs of the NBS examination
at different times or by different examiners. The exact distinction between
functional
brain tissue and
tumor by NBS facilitated in the treatment of
lowgrade gliomas in 6 of 11 cases the early and complete
tumor resection. 1.4
CONCLUSIONS This dissertation shows that the NBS Motormapping is highly
reliable for preoperative diagnostics. The correlations between
neuropysiological data and clinical outcome which were found make a prognostic
Model based on this Data feasible. In clinical practice in half of the cases
NBS results lead to a change of the treatment plan which was solely based on
MRTs before. The influence of NBS on the therapy was especially confirmed for
patients with lowgrade gliomas – here the results showed a significantly
better treatment outcome if NBS was used preoperatively.
Advisors/Committee Members: [email protected] (contact), w (gender), N.N. (firstReferee), N.N. (furtherReferee).
Subjects/Keywords: transcranial brain stimulation; brain mapping; brain tumor surgery; eloquent areas; magnetic stimulation; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
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APA (6th Edition):
Schulz, J. (2015). validity, influence on the surgical strategie and prognostic value. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-13314
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Schulz, Juliane. “validity, influence on the surgical strategie and prognostic value.” 2015. Thesis, Freie Universität Berlin. Accessed January 18, 2021.
http://dx.doi.org/10.17169/refubium-13314.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Schulz, Juliane. “validity, influence on the surgical strategie and prognostic value.” 2015. Web. 18 Jan 2021.
Vancouver:
Schulz J. validity, influence on the surgical strategie and prognostic value. [Internet] [Thesis]. Freie Universität Berlin; 2015. [cited 2021 Jan 18].
Available from: http://dx.doi.org/10.17169/refubium-13314.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Schulz J. validity, influence on the surgical strategie and prognostic value. [Thesis]. Freie Universität Berlin; 2015. Available from: http://dx.doi.org/10.17169/refubium-13314
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Universiteit Utrecht
3.
Toorn, R. van den.
Spatial Attentional Functioning in Adult Brain Tumor Patients.
Degree: 2011, Universiteit Utrecht
URL: http://dspace.library.uu.nl:8080/handle/1874/210567
► Background. Cognitive functioning is at risk in patients with gliomas because of the infiltration of healthy surrounding brain tissue. Cognitive changes can be related to…
(more)
▼ Background. Cognitive functioning is at risk in patients with gliomas because of the infiltration of healthy surrounding
brain tissue. Cognitive changes can be related to direct
tumor effects, treatment effects including
surgery, radiotherapy, chemotherapy, antiepileptic medication, and corticosteroids, and ultimately,
tumor progression. Objective. We determined the impact of resective
surgery on cognitive functioning by comparing pre- and postoperative neuropsychological outcome specifically focusing on attentional functioning (as measured by the Stroop Color Word Test (SCWT)). Methods. 24 adult patients (10 females, median age: 40, range: 20-64) with supratentorial gliomas (WHO II: 17, WHO III: 3 and WHO IV: 4) underwent neurosurgery of which 17 in eloquent
brain regions using intraoperative
brain mapping. Neuropsychological examination was administered approximately one week before
surgery and 9 months thereafter. Outcome was analyzed at the group and individual level. Several predictive factors for potential cognitive deterioration were explored.
Results. Deterioration following
surgery in reading speed (performance on Card 1, SCWT) was observed at group level. The effect of predictive factors and individual analyses showed that more extensive resections (i.e. >80%) and tumors located in language eloquent areas yielded clinically relevant deterioration in reading speed. Conclusion. Deterioration in reading speed was found clinically relevant in the predictive dichotomies Extent of Resection (EOR) and language eloquent area. In these patients, both
tumor location and location of surgical intervention suggest involvement of the superior longitudinal fasciculus (SLF II). Extra attention should be sought in this particular region during resective
brain surgery along with further research in order to map spatial attention in a more accurate way.
Advisors/Committee Members: Dijkerman, C..
Subjects/Keywords: Sociale Wetenschappen; Brain tumor; glioma; resective tumor surgery; cognitive functioning; reading speed; spatial attentional functioning; health related quality of life
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APA (6th Edition):
Toorn, R. v. d. (2011). Spatial Attentional Functioning in Adult Brain Tumor Patients. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/210567
Chicago Manual of Style (16th Edition):
Toorn, R van den. “Spatial Attentional Functioning in Adult Brain Tumor Patients.” 2011. Masters Thesis, Universiteit Utrecht. Accessed January 18, 2021.
http://dspace.library.uu.nl:8080/handle/1874/210567.
MLA Handbook (7th Edition):
Toorn, R van den. “Spatial Attentional Functioning in Adult Brain Tumor Patients.” 2011. Web. 18 Jan 2021.
Vancouver:
Toorn Rvd. Spatial Attentional Functioning in Adult Brain Tumor Patients. [Internet] [Masters thesis]. Universiteit Utrecht; 2011. [cited 2021 Jan 18].
Available from: http://dspace.library.uu.nl:8080/handle/1874/210567.
Council of Science Editors:
Toorn Rvd. Spatial Attentional Functioning in Adult Brain Tumor Patients. [Masters Thesis]. Universiteit Utrecht; 2011. Available from: http://dspace.library.uu.nl:8080/handle/1874/210567
Freie Universität Berlin
4.
Rosenstock, Tizian.
Präoperative Risikostratifizierung für das funktionelle Ergebnis bei
Tumorresektionen in motorischen Arealen.
Degree: 2018, Freie Universität Berlin
URL: http://dx.doi.org/10.17169/refubium-6070
► Einleitung. Für Patienten mit einem motorisch-eloquent gelegenen Hirntumor hat sich die navigierte transkranielle Magnetstimulation (nTMS) als nicht-invasive Untersuchungsmethode etabliert, um motorisch-funktionelle Areale präoperativ zu identifizieren.…
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▼ Einleitung. Für Patienten mit einem motorisch-eloquent gelegenen Hirntumor hat
sich die navigierte transkranielle Magnetstimulation (nTMS) als nicht-invasive
Untersuchungsmethode etabliert, um motorisch-funktionelle Areale präoperativ
zu identifizieren. Das Ziel dieser Studie war es zu analysieren, ob und
inwiefern sich die durch die nTMS-Untersuchung bereitgestellten Daten dazu
eignen, das Risiko für das Auftreten einer neuen oder der Verschlechterung
einer bereits präoperativ bestehenden Parese in Form eines statistisch
prädiktiven Models zu stratifizieren. Methoden. Einhundertdreizehn Patienten,
die zwischen Oktober 2007 und Dezember 2014 an einem hirneigenen
Tumor in
(potenziell) motorisch-eloquenter Lage in der Klinik für Neurochirurgie der
Charité operiert wurden, unterzogen sich präoperativ der bihemisphärischen
nTMS-Untersuchung. Anschließend erfolgte die Evaluation in der OP-
Planungssoftware iPlan 2.0 (
Brain Lab), mit welcher eine auf Diffusions-
Tensor-Bildgebung basierende Faserbahndarstellung des kortikospinalen Traktes
erfolgte. Mit den prospektiv gesammelten Daten erfolgte zunächst eine
univariate Analyse bzgl. des motorischen Status nach 7 Tagen (=
Entlassungstag) und 3 Monaten. Anschließend wurde mithilfe der signifkanten
Variablen eine multiple ordinale logistische Regressionsanalyse durchgeführt,
um Prädiktoren für das motorische Outcome der Patienten zu identifizieren.
Ergebnisse. Ein verschlechterter motorischer Status wurde in 20% der Fälle
nach 7 Tagen und in 22% der Fälle nach 3 Monaten beobachtet. Patienten
erlitten nie ein neues motorisches Defizit, wenn der minimale subkortikale
Abstand zwischen dem
Tumor und der nTMS-basierten Darstellung des
kortikospinalen Traktes größer als 8mm war und keine kortikale tumoröse
Infiltration des Motorkortex nachweisbar war (p = 0.014). Eine postoperative
motorische Verschlechterung nach 7 Tagen war mit einem pathologischen
interhemisphärischen Erregungsverhältnis (interhemisphärischer „resting motor
threshold“ (RMT)-Quotient < 90% bzw. > 110%) assoziiert (p = 0.031). Eine
präoperative Parese bildete sich bei Patienten, deren RMT-Quotient > 110% lag,
nie zurück. Zusammenfassung. Die auf anatomisch-funktionellen und
neurophysiologischen Daten basierende Risikostratifizierung erlaubt es, die
Wahrscheinlichkeit für eine motorisch-funktionelle Verschlechterung bzw.
Besserung zu quantifizieren. Diese Information kann genutzt werden, um die
Notwendigkeit von intraoperativem neurophysiologischen Monitoring
einzuschätzen und in Konsens mit dem Patienten eine individualisierte
Behandlungsstrategie festzulegen.
Advisors/Committee Members: [email protected] (contact), m (gender), N.N. (firstReferee), N.N. (furtherReferee).
Subjects/Keywords: navigated transcranial magnetic stimulation; brain tumor surgery; glioma; predictive model; motor outcome; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
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APA ·
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Manager
APA (6th Edition):
Rosenstock, T. (2018). Präoperative Risikostratifizierung für das funktionelle Ergebnis bei
Tumorresektionen in motorischen Arealen. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-6070
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Rosenstock, Tizian. “Präoperative Risikostratifizierung für das funktionelle Ergebnis bei
Tumorresektionen in motorischen Arealen.” 2018. Thesis, Freie Universität Berlin. Accessed January 18, 2021.
http://dx.doi.org/10.17169/refubium-6070.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Rosenstock, Tizian. “Präoperative Risikostratifizierung für das funktionelle Ergebnis bei
Tumorresektionen in motorischen Arealen.” 2018. Web. 18 Jan 2021.
Vancouver:
Rosenstock T. Präoperative Risikostratifizierung für das funktionelle Ergebnis bei
Tumorresektionen in motorischen Arealen. [Internet] [Thesis]. Freie Universität Berlin; 2018. [cited 2021 Jan 18].
Available from: http://dx.doi.org/10.17169/refubium-6070.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Rosenstock T. Präoperative Risikostratifizierung für das funktionelle Ergebnis bei
Tumorresektionen in motorischen Arealen. [Thesis]. Freie Universität Berlin; 2018. Available from: http://dx.doi.org/10.17169/refubium-6070
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Lund
5.
Janelidze, Shorena.
Experimental brain tumors, dendritic cells and
immunotherapy.
Degree: 2008, University of Lund
URL: https://lup.lub.lu.se/record/1059180
;
https://portal.research.lu.se/ws/files/3228198/1149899.pdf
► Malignant astrocytomas are the most common primary tumors of the adult central nervous system. Surgical resection of tumor mass in combination with radiotherapy and chemotherapy…
(more)
▼ Malignant astrocytomas are the most common primary
tumors of the adult central nervous system. Surgical resection of
tumor mass in combination with radiotherapy and chemotherapy is
only palliative and there is a clear need for new and more
effective therapeutic strategies. The aim of this study was to
develop a dendritic cell (DC)-based vaccine for the treatment of
experimental brain tumors with the future prospect of translating
this treatment into the clinical application. We first demonstrated
that the N29 and N32 rat brain tumors closely resemble human
glioblastoma multiforme and anaplastic astrocytoma, respectively,
and represent relevant models to study the efficacy of new
therapeutic modalities. We also found that vaccination with
IFN-γ-producing tumor cells led to tumor regression in a fraction
of animals in both tumor models. The route of vaccine
administration significantly influenced the outcome of the therapy.
S.c. immunization with IFN-γ-producing tumor cells was far more
effective compared to i.d. injection. DCs generated from rat bone
marrow progenitor cells exhibited the capacity to take up antigens
in an immature state and induce T cell proliferation in a mature
state, two functional properties central for the induction of
anti-tumor immune response. We tested different antigen
preparations and maturation factors in order to establish the
optimal conditions for DC activation. Synergistic inhibition of
intracerebral tumor growth was observed when rats were vaccinated
with a combination of ex vivo tumor cell lysate-pulsed and matured
DCs and IFN-γ-producing tumor cells. However, we did not observe
any benefit of using DC-based vaccines alone regardless of antigen
loading or maturation methods compared to immunotherapy with
IFN-γ-producing tumor cells. In conclusion, we have demonstrated
that DC-based vaccines fail to provide protection in a weakly
immunogenic brain tumor model but do enhance the anti-tumor immune
responses elicited by IFN-γ-producing tumor cells. These findings
could be pertinent to other tumor models and other
immunotherapeutic modalities and thus have important implications
for the development of anti-cancer vaccines.
Subjects/Keywords: Neurology; Surgery; dendritic cell; interferon-γ; immunotherapy; Brain tumor
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APA (6th Edition):
Janelidze, S. (2008). Experimental brain tumors, dendritic cells and
immunotherapy. (Doctoral Dissertation). University of Lund. Retrieved from https://lup.lub.lu.se/record/1059180 ; https://portal.research.lu.se/ws/files/3228198/1149899.pdf
Chicago Manual of Style (16th Edition):
Janelidze, Shorena. “Experimental brain tumors, dendritic cells and
immunotherapy.” 2008. Doctoral Dissertation, University of Lund. Accessed January 18, 2021.
https://lup.lub.lu.se/record/1059180 ; https://portal.research.lu.se/ws/files/3228198/1149899.pdf.
MLA Handbook (7th Edition):
Janelidze, Shorena. “Experimental brain tumors, dendritic cells and
immunotherapy.” 2008. Web. 18 Jan 2021.
Vancouver:
Janelidze S. Experimental brain tumors, dendritic cells and
immunotherapy. [Internet] [Doctoral dissertation]. University of Lund; 2008. [cited 2021 Jan 18].
Available from: https://lup.lub.lu.se/record/1059180 ; https://portal.research.lu.se/ws/files/3228198/1149899.pdf.
Council of Science Editors:
Janelidze S. Experimental brain tumors, dendritic cells and
immunotherapy. [Doctoral Dissertation]. University of Lund; 2008. Available from: https://lup.lub.lu.se/record/1059180 ; https://portal.research.lu.se/ws/files/3228198/1149899.pdf
Linköping University
6.
Mattsson, Matilda.
Substantiv- och verbbenämning vid repetitiv navigerad transkraniell magnetstimulering (rnTMS) i kombination med språklig testning : En pilotstudie för kartläggning av språkliga områden i hjärnan.
Degree: Division of Sensory Organs and Communication, 2020, Linköping University
URL: http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-166010
► Repetitiv navigerad transkraniell magnetstimulering (rnTMS) används preoperativt för att kartlägga kortikala, språkligt relevanta områden i hjärnan. I nuläget används substantivbenämning vid rnTMS, men det…
(more)
▼ Repetitiv navigerad transkraniell magnetstimulering (rnTMS) används preoperativt för att kartlägga kortikala, språkligt relevanta områden i hjärnan. I nuläget används substantivbenämning vid rnTMS, men det råder delade uppfattningar i aktuell forskning huruvida substantiv- eller verbbenämning är känsligast för stimulering och därför krävs mer forskning inom området. I föreliggande studie kompletterades substantivbenämningen med verbbenämning. Alla deltagare genomgick även preoperativ språklig testning och en av deltagarna genomgick också postoperativ språklig testning. Syftet med föreliggande studie var att jämföra skillnader vid expressiv språklig förmåga vid substantiv- och verbbenämning och att kartlägga språkliga funktioners utbredning i hjärnan, samt att identifiera ytterligare kliniska markörer för bestående språkliga svårigheter efter hjärnkirurgi. Studien syftade även till att undersöka huruvida det preoperativa rnTMS-resultatet överensstämmer med det postoperativa kirurgiresultatet. Studien hade fem deltagare, varav tre med hjärntumör och två med epilepsi, som skulle genomgå vaken hjärnkirurgi. Deltagarnas rnTMS- undersökning videoinspelades och deras språkliga testning ljudinspelades. Analyser genomfördes på individ- och gruppnivå. Resultaten visade att stimulering under verbbenämning inte orsakade signifikant fler felsvar än stimulering vid substantivbenämning, även om felsvaren vid verbbenämning var procentuellt fler. Däremot resulterade de två ordklasserna i olika felsvarslokalisationer hos samtliga deltagare. De tre vanligaste typerna av felsvar på gruppnivå var ändring av grammatisk ändelse, tvekljud samt byte till synonym och de vanligaste felsvarslokalisationena var gyrus frontalis medius, gyrus frontalis inferior och gyrus precentralis. Gällande den språkliga testningen fick deltagarna väldigt spridda resultat. Sammanfattningsvis verkar benämning av substantiv och verb komplettera varandra och båda ordklasserna bör användas vid rnTMS om metoden fortsätter att användas. Även patienternas högre språkliga förmåga (HLL) bör testas inför hjärnkirurgi. Avslutningsvis indikerar resultaten på att språkets placering i hjärnan är både mycket utbredd och väldigt individuell.
Repetitive navigated transcranial magnetic stimulation (rnTMS) is used preoperatively to map cortical areas in the brain that are important for language. Object naming is currently being used during rnTMS, but current research has differing opinions on whether naming of objects or actions are most sensitive to stimulation. Therefore, further research is needed in the field. In this study, object naming was combined with action naming. All of the participants also underwent language tests preoperatively and one of the participants underwent postoperative language tests as well. The aim of the present study was to compare differences in expressive language during object and action naming as well as to map the distribution…
Subjects/Keywords: brain tumor; epilepsy; TMS; object naming; action naming; brain surgery; language mapping; BeSS; hjärntumör; epilepsi; TMS; substantivbenämning; verbbenämning; hjärnkirurgi; språklig kartläggning; BeSS; Other Health Sciences; Annan hälsovetenskap
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APA ·
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APA (6th Edition):
Mattsson, M. (2020). Substantiv- och verbbenämning vid repetitiv navigerad transkraniell magnetstimulering (rnTMS) i kombination med språklig testning : En pilotstudie för kartläggning av språkliga områden i hjärnan. (Thesis). Linköping University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-166010
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Mattsson, Matilda. “Substantiv- och verbbenämning vid repetitiv navigerad transkraniell magnetstimulering (rnTMS) i kombination med språklig testning : En pilotstudie för kartläggning av språkliga områden i hjärnan.” 2020. Thesis, Linköping University. Accessed January 18, 2021.
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-166010.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Mattsson, Matilda. “Substantiv- och verbbenämning vid repetitiv navigerad transkraniell magnetstimulering (rnTMS) i kombination med språklig testning : En pilotstudie för kartläggning av språkliga områden i hjärnan.” 2020. Web. 18 Jan 2021.
Vancouver:
Mattsson M. Substantiv- och verbbenämning vid repetitiv navigerad transkraniell magnetstimulering (rnTMS) i kombination med språklig testning : En pilotstudie för kartläggning av språkliga områden i hjärnan. [Internet] [Thesis]. Linköping University; 2020. [cited 2021 Jan 18].
Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-166010.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Mattsson M. Substantiv- och verbbenämning vid repetitiv navigerad transkraniell magnetstimulering (rnTMS) i kombination med språklig testning : En pilotstudie för kartläggning av språkliga områden i hjärnan. [Thesis]. Linköping University; 2020. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-166010
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Vanderbilt University
7.
Coffey, Aaron Michael.
Prediction of patient orientation with minimized lateral shift for brain tumor resection therapies.
Degree: MS, Biomedical Engineering, 2010, Vanderbilt University
URL: http://hdl.handle.net/1803/12011
► This work demonstrates a predictive tool to aid neurosurgeons in planning tumor resection therapies by finding the optimal patient orientation that minimizes lateral brain shift…
(more)
▼ This work demonstrates a predictive tool to aid neurosurgeons in planning
tumor resection therapies by finding the optimal patient orientation that minimizes lateral
brain shift in the field of view. Such orientations facilitate
tumor access and removal, can reduce the need for retraction, and minimize the impact of
brain shift on image guided procedures. In this study, high resolution preoperative magnetic resonance images were utilized in conjunction with pre- and post-resection laser range scans of the craniotomy to produce patient specific finite element models for 6 cases. The cases included 2 large frontal lobe tumors, 3 temporal lobe tumors, and 1 temporal-parietal
tumor. General rules for applying resection and modifying model parameters were developed that were consistent with minimal shift within operating room data. In addition, an objective function is introduced to determine patient presentation such that the impact
brain shift is minimized. A comparison of the optimal patient presentations as determined by the model-driven objective function to the surgical presentations selected to be optimal by our practicing neurosurgeon [RCT] is performed for 6 cases and demonstrated differences in head rotation angles ranging on average of 8.2°-13.2° and head tilt angles ranging on average 14.7° - 24.4°.
Advisors/Committee Members: Reid C. Thompson (committee member), Michael I. Miga (Committee Chair).
Subjects/Keywords: finite elements; retraction; brain shift; patient positioning; tumor resection; image-guided surgery
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APA (6th Edition):
Coffey, A. M. (2010). Prediction of patient orientation with minimized lateral shift for brain tumor resection therapies. (Thesis). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/12011
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Coffey, Aaron Michael. “Prediction of patient orientation with minimized lateral shift for brain tumor resection therapies.” 2010. Thesis, Vanderbilt University. Accessed January 18, 2021.
http://hdl.handle.net/1803/12011.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Coffey, Aaron Michael. “Prediction of patient orientation with minimized lateral shift for brain tumor resection therapies.” 2010. Web. 18 Jan 2021.
Vancouver:
Coffey AM. Prediction of patient orientation with minimized lateral shift for brain tumor resection therapies. [Internet] [Thesis]. Vanderbilt University; 2010. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/1803/12011.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Coffey AM. Prediction of patient orientation with minimized lateral shift for brain tumor resection therapies. [Thesis]. Vanderbilt University; 2010. Available from: http://hdl.handle.net/1803/12011
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Arizona State University
8.
BELYKH, Evgenii.
Visualization of Brain Tumors with Intraoperative Confocal
Laser Endomicroscopy.
Degree: Neuroscience, 2020, Arizona State University
URL: http://repository.asu.edu/items/57300
Subjects/Keywords: Neurosciences; Medical imaging; Surgery; 5-AMINOLEVULINIC ACID; BRAIN TUMOR; CONFOCAL; ENDOMICROSCOPY; FLUORESCEIN; FLUORESCENCE
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Record Details
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
BELYKH, E. (2020). Visualization of Brain Tumors with Intraoperative Confocal
Laser Endomicroscopy. (Doctoral Dissertation). Arizona State University. Retrieved from http://repository.asu.edu/items/57300
Chicago Manual of Style (16th Edition):
BELYKH, Evgenii. “Visualization of Brain Tumors with Intraoperative Confocal
Laser Endomicroscopy.” 2020. Doctoral Dissertation, Arizona State University. Accessed January 18, 2021.
http://repository.asu.edu/items/57300.
MLA Handbook (7th Edition):
BELYKH, Evgenii. “Visualization of Brain Tumors with Intraoperative Confocal
Laser Endomicroscopy.” 2020. Web. 18 Jan 2021.
Vancouver:
BELYKH E. Visualization of Brain Tumors with Intraoperative Confocal
Laser Endomicroscopy. [Internet] [Doctoral dissertation]. Arizona State University; 2020. [cited 2021 Jan 18].
Available from: http://repository.asu.edu/items/57300.
Council of Science Editors:
BELYKH E. Visualization of Brain Tumors with Intraoperative Confocal
Laser Endomicroscopy. [Doctoral Dissertation]. Arizona State University; 2020. Available from: http://repository.asu.edu/items/57300
Virginia Tech
9.
Garcia, Paulo A.
Irreversible Electroporation for the Treatment of Aggressive High-Grade Glioma.
Degree: PhD, Biomedical Engineering, 2010, Virginia Tech
URL: http://hdl.handle.net/10919/77269
► Malignant gliomas (MG), most notably glioblastoma multiforme (GBM), are among the most aggressive of all malignancies. High-grade variants of this type of brain cancer are…
(more)
▼ Malignant gliomas (MG), most notably glioblastoma multiforme (GBM), are among the most aggressive of all malignancies. High-grade variants of this type of
brain cancer are generally considered incurable with singular or multimodal therapies. Many patients with GBM die within one year of diagnosis, and the 5-year survival rate in people is approximately 10%. Despite extensive research in diagnostic and therapeutic technologies, very few developments have emerged that significantly improve survival over the last seven decades.
Irreversible electroporation (IRE) is a new non-thermal focal tissue ablation technique that uses low-energy electric pulses to destabilize cell membranes, thus achieving tissue death. The procedure is minimally invasive and is performed through small electrodes inserted into the tissue with treatment duration of about one minute. The pulses create an electric field that induces an increase in the resting transmembrane potential (TMP) of the cells in the tissue. The induced increase in the TMP is dependent on the electric pulse parameters. Depending on the magnitude of the induced TMP the electric pulses can have no effect, transiently increase membrane permeability or cause spontaneous death.
In this dissertation we hypothesize that irreversible electroporation is capable of ablating normal (gray and white matter) and pathological (MG and/or GBM)
brain tissue in a highly focused non-thermal manner that is modulated through pulse parameters and electrode configuration. Through a comprehensive experimental and numerical investigation, we tested and attained results strongly supporting our hypothesis. Specifically, we developed numerical models that were capable of simulating an entire IRE treatment protocol and would take into account pulse parameters (e.g. duration, frequency, repetition rate and strength) in addition to the dynamic changes in tissue electrical conductivity due to electroporation and joule heating, as well as biologically relevant processes such as blood perfusion and metabolic heat. We also provided a method to isolate the IRE effects from undesired thermal damage in models that were validated with real-time temperature measurements during the delivery of the pulses. Finally we outlined a procedure to use 3D volumetric reconstructions of IRE lesions using patient specific MRI scans in conjunction with the models described for establishing field thresholds or performing treatment planning prior to the surgical procedure; thus supplying the readers with the tools and understanding necessary to design appropriate treatment protocols for their specific application.
Experimentally we presented the first systematic in vivo study of IRE in normal canine
brain and the multimodal treatment of a canine MG patient. We confirmed that the procedure can be applied safely in the
brain and was well tolerated clinically. The lesions created with IRE were sub-millimeter in resolution and we achieved 75%
tumor volume reduction within 3 days post-IRE in the patient. In addition to the sharp…
Advisors/Committee Members: Davalos, Rafael V. (committeechair), Wang, Ge (committee member), Robertson, John L. (committee member), Rossmeisl, John H. Jr. (committee member), Rylander, Christopher G. (committee member).
Subjects/Keywords: Nonthermal Ablation; Tumor Ablation; Minimally Invasive Surgery; Brain Cancer Therapy; Malignant Glioma
Record Details
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Record Details
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APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Garcia, P. A. (2010). Irreversible Electroporation for the Treatment of Aggressive High-Grade Glioma. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/77269
Chicago Manual of Style (16th Edition):
Garcia, Paulo A. “Irreversible Electroporation for the Treatment of Aggressive High-Grade Glioma.” 2010. Doctoral Dissertation, Virginia Tech. Accessed January 18, 2021.
http://hdl.handle.net/10919/77269.
MLA Handbook (7th Edition):
Garcia, Paulo A. “Irreversible Electroporation for the Treatment of Aggressive High-Grade Glioma.” 2010. Web. 18 Jan 2021.
Vancouver:
Garcia PA. Irreversible Electroporation for the Treatment of Aggressive High-Grade Glioma. [Internet] [Doctoral dissertation]. Virginia Tech; 2010. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/10919/77269.
Council of Science Editors:
Garcia PA. Irreversible Electroporation for the Treatment of Aggressive High-Grade Glioma. [Doctoral Dissertation]. Virginia Tech; 2010. Available from: http://hdl.handle.net/10919/77269
. 
Open Access Theses and Dissertations