subject:(blood flow measurement)

East Carolina University

1. Kehe, Sarah. VARIABILITY IN POPLITEAL ARTERY BLOOD FLOW : EFFECT OF EXERCISE TRAINING.

Degree: 2012, East Carolina University

URL: http://libres.uncg.edu/ir/listing.aspx?styp=ti&id=14832

► Mean arterial pressure (MAP) is regulated through changes in cardiac output (Q) and total peripheral resistance (TPR) where Q = heart rate (HR) x stroke… (more)

Subjects/Keywords: Blood flow – Measurement; Aerobic exercises

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APA (6^th Edition):

Kehe, S. (2012). VARIABILITY IN POPLITEAL ARTERY BLOOD FLOW : EFFECT OF EXERCISE TRAINING. (Masters Thesis). East Carolina University. Retrieved from http://libres.uncg.edu/ir/listing.aspx?styp=ti&id=14832

Chicago Manual of Style (16^th Edition):

Kehe, Sarah. “VARIABILITY IN POPLITEAL ARTERY BLOOD FLOW : EFFECT OF EXERCISE TRAINING.” 2012. Masters Thesis, East Carolina University. Accessed January 19, 2021. http://libres.uncg.edu/ir/listing.aspx?styp=ti&id=14832.

MLA Handbook (7^th Edition):

Kehe, Sarah. “VARIABILITY IN POPLITEAL ARTERY BLOOD FLOW : EFFECT OF EXERCISE TRAINING.” 2012. Web. 19 Jan 2021.

Vancouver:

Kehe S. VARIABILITY IN POPLITEAL ARTERY BLOOD FLOW : EFFECT OF EXERCISE TRAINING. [Internet] [Masters thesis]. East Carolina University; 2012. [cited 2021 Jan 19]. Available from: http://libres.uncg.edu/ir/listing.aspx?styp=ti&id=14832.

Council of Science Editors:

Kehe S. VARIABILITY IN POPLITEAL ARTERY BLOOD FLOW : EFFECT OF EXERCISE TRAINING. [Masters Thesis]. East Carolina University; 2012. Available from: http://libres.uncg.edu/ir/listing.aspx?styp=ti&id=14832

East Carolina University

2. Kehe, Sarah. VARIABILITY IN POPLITEAL ARTERY BLOOD FLOW : EFFECT OF EXERCISE TRAINING.

Degree: MS, Exercise and Sport Science, 2012, East Carolina University

URL: http://hdl.handle.net/10342/3951

► Mean arterial pressure (MAP) is regulated through changes in cardiac output (Q) and total peripheral resistance (TPR), where Q = heart rate (HR) x stroke… (more)

Subjects/Keywords: Kinesiology; Blood flow; Exercise; Popliteal; Blood flow – Measurement; Aerobic exercises

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APA (6^th Edition):

Kehe, S. (2012). VARIABILITY IN POPLITEAL ARTERY BLOOD FLOW : EFFECT OF EXERCISE TRAINING. (Masters Thesis). East Carolina University. Retrieved from http://hdl.handle.net/10342/3951

Chicago Manual of Style (16^th Edition):

Kehe, Sarah. “VARIABILITY IN POPLITEAL ARTERY BLOOD FLOW : EFFECT OF EXERCISE TRAINING.” 2012. Masters Thesis, East Carolina University. Accessed January 19, 2021. http://hdl.handle.net/10342/3951.

MLA Handbook (7^th Edition):

Kehe, Sarah. “VARIABILITY IN POPLITEAL ARTERY BLOOD FLOW : EFFECT OF EXERCISE TRAINING.” 2012. Web. 19 Jan 2021.

Vancouver:

Kehe S. VARIABILITY IN POPLITEAL ARTERY BLOOD FLOW : EFFECT OF EXERCISE TRAINING. [Internet] [Masters thesis]. East Carolina University; 2012. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/10342/3951.

Council of Science Editors:

Kehe S. VARIABILITY IN POPLITEAL ARTERY BLOOD FLOW : EFFECT OF EXERCISE TRAINING. [Masters Thesis]. East Carolina University; 2012. Available from: http://hdl.handle.net/10342/3951

Macquarie University

3. Adji, Audrey Indrawati (Sutanto). Non-invasive characterisation of age-related changes in ascending aortic blood pressure and blood flow: from old concept to novel approach.

Degree: 2016, Macquarie University

URL: http://hdl.handle.net/1959.14/1074250

►

Thesis by publication.

Bibliography: pages 449-472.

Chapter 1. Introduction – Chapter 2. Literature review – Chapter 3. Accuracy of distance measurement in the measurement of… (more)

▼

Thesis by publication.

Bibliography: pages 449-472.

Chapter 1. Introduction – Chapter 2. Literature review – Chapter 3. Accuracy of distance measurement in the measurement of “aortic” pulse wave velocity – Chapter 4. Non-invasive central aortic pressure measurements : calibration and clinical value – Chapter 5. Characterisation of age-related changes in aortic pressure and flow – Chapter 6. Relationship of cerebral arterial pressure and flow with aortic pressure and flow – Chapter 7. Published reviews, editorials and commentaries pertaining to the thesis topic – Chapter 8. Conclusion.

The elucidation of mechanisms whereby arterial stiffness with increasing age alters the propagation of pressure (and flow ejection) waves generated by each heart beat is still evolving and sometimes debated. The research described in this thesis aims to better characterise the age-related changes in ascending aortic blood pressure and blood flow non-invasively.

This thesis investigates four key areas:- (i) measurement of aortic stiffness with pulse wave velocity; (ii) non-invasive central arterial pressure measurements; (iii) characterisation of age-related changes in central aortic pressure and flow with non-invasive methodology; (iv) relationship of cerebral arterial pressure and flow with central aortic pressure and flow.

Findings of this investigation highlight the clinical importance of non-invasive measurement of central aortic pressure and aortic flow to determine ascending aortic impedance as a measure of cardiac load. The physical relationship between aortic pressure, flow and arterial impedance is quantified in terms of age-related changes. Changes in aortic flow pattern and means to derive aortic flow waveform from aortic pressure waveform non-invasively are compared with other methods. Results show that changes in the cardiac ejection pattern with age are better determined using magnetic resonance imaging compared to Doppler ultrasound techniques. Initial investigation of the effect of arterial stiffening, as occurs with age, shows that there is a relationship between the higher pressure pulsations from the heart and the damage in the brain due to the higher flow pulsations being transferred to the cerebral circulation.

This investigation confirmed the changes in central aortic blood pressure and flow ejection with aging. Derivation of the aortic flow pattern from central aortic pressure is feasible, through their relationship with aortic impedance. Increased pulsatility of arterial pressure and flow may cause damage to the microvasculature in the brain and may relate to the cognitive decline with aging and disease.

1 online resource (xx, 489 pages) illustrations (some colour)

Advisors/Committee Members: Macquarie University. Department of Biomedical Sciences.

Subjects/Keywords: Blood pressure – Measurement; Blood flow – Measurement; Aorta; aging; ascending aortic pressure; ascending aortic flow velocity

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APA (6^th Edition):

Adji, A. I. (. (2016). Non-invasive characterisation of age-related changes in ascending aortic blood pressure and blood flow: from old concept to novel approach. (Doctoral Dissertation). Macquarie University. Retrieved from http://hdl.handle.net/1959.14/1074250

Chicago Manual of Style (16^th Edition):

Adji, Audrey Indrawati (Sutanto). “Non-invasive characterisation of age-related changes in ascending aortic blood pressure and blood flow: from old concept to novel approach.” 2016. Doctoral Dissertation, Macquarie University. Accessed January 19, 2021. http://hdl.handle.net/1959.14/1074250.

MLA Handbook (7^th Edition):

Adji, Audrey Indrawati (Sutanto). “Non-invasive characterisation of age-related changes in ascending aortic blood pressure and blood flow: from old concept to novel approach.” 2016. Web. 19 Jan 2021.

Vancouver:

Adji AI(. Non-invasive characterisation of age-related changes in ascending aortic blood pressure and blood flow: from old concept to novel approach. [Internet] [Doctoral dissertation]. Macquarie University; 2016. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/1959.14/1074250.

Council of Science Editors:

Adji AI(. Non-invasive characterisation of age-related changes in ascending aortic blood pressure and blood flow: from old concept to novel approach. [Doctoral Dissertation]. Macquarie University; 2016. Available from: http://hdl.handle.net/1959.14/1074250

Michigan State University

4. Saggio, Frank. Random signal ultrasonic blood flow detection.

Degree: MS, 1973, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:7106

Subjects/Keywords: Blood flow – Measurement; Blood volume

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APA (6^th Edition):

Saggio, F. (1973). Random signal ultrasonic blood flow detection. (Masters Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:7106

Chicago Manual of Style (16^th Edition):

Saggio, Frank. “Random signal ultrasonic blood flow detection.” 1973. Masters Thesis, Michigan State University. Accessed January 19, 2021. http://etd.lib.msu.edu/islandora/object/etd:7106.

MLA Handbook (7^th Edition):

Saggio, Frank. “Random signal ultrasonic blood flow detection.” 1973. Web. 19 Jan 2021.

Vancouver:

Saggio F. Random signal ultrasonic blood flow detection. [Internet] [Masters thesis]. Michigan State University; 1973. [cited 2021 Jan 19]. Available from: http://etd.lib.msu.edu/islandora/object/etd:7106.

Council of Science Editors:

Saggio F. Random signal ultrasonic blood flow detection. [Masters Thesis]. Michigan State University; 1973. Available from: http://etd.lib.msu.edu/islandora/object/etd:7106

Ryerson University

5. Bedkihal, Salil K. Simulations Of Steady Flows Through Cylindrical Geometries With And Without Local Constrictions By Multiparticle Collision Dynamics.

Degree: 2010, Ryerson University

URL: https://digital.library.ryerson.ca/islandora/object/RULA%3A1471

► In this thesis, a recently developed particle-based method called multiparticle collision dynamics (MPC) is used to simulate steady flows through three-dimensional constricted axisymmetric cylinders. The… (more)

Subjects/Keywords: Blood flow; Blood flow – Measurement; Fluid mechanics – Mathematical models; Navier-Stokes equations; Non-Newtonian fluids

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APA (6^th Edition):

Bedkihal, S. K. (2010). Simulations Of Steady Flows Through Cylindrical Geometries With And Without Local Constrictions By Multiparticle Collision Dynamics. (Thesis). Ryerson University. Retrieved from https://digital.library.ryerson.ca/islandora/object/RULA%3A1471

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bedkihal, Salil K. “Simulations Of Steady Flows Through Cylindrical Geometries With And Without Local Constrictions By Multiparticle Collision Dynamics.” 2010. Thesis, Ryerson University. Accessed January 19, 2021. https://digital.library.ryerson.ca/islandora/object/RULA%3A1471.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bedkihal, Salil K. “Simulations Of Steady Flows Through Cylindrical Geometries With And Without Local Constrictions By Multiparticle Collision Dynamics.” 2010. Web. 19 Jan 2021.

Vancouver:

Bedkihal SK. Simulations Of Steady Flows Through Cylindrical Geometries With And Without Local Constrictions By Multiparticle Collision Dynamics. [Internet] [Thesis]. Ryerson University; 2010. [cited 2021 Jan 19]. Available from: https://digital.library.ryerson.ca/islandora/object/RULA%3A1471.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bedkihal SK. Simulations Of Steady Flows Through Cylindrical Geometries With And Without Local Constrictions By Multiparticle Collision Dynamics. [Thesis]. Ryerson University; 2010. Available from: https://digital.library.ryerson.ca/islandora/object/RULA%3A1471

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

New Jersey Institute of Technology

6. Shah, Riddhi Harsh. Use of fluorescent micropsheres to measure coronary flow reserve in rat animal model.

Degree: MSin Biomedical Engineering - (M.S.), Biomedical Engineering, 2011, New Jersey Institute of Technology

URL: https://digitalcommons.njit.edu/theses/116

► Heart attacks result from reduced or blocked blood flow through major coronary arteries, resulting in permanent damage to heart muscle. Coronary blood flow (CBF)… (more)

▼ Heart attacks result from reduced or blocked blood flow through major coronary arteries, resulting in permanent damage to heart muscle. Coronary blood flow (CBF) is thus important to measure in experimental animal models of heart disease. A standard method to measure CBF uses tracer microspheres (Ø = 15 µm) injected into the left ventricle that flow through coronary arteries but cannot pass through capillaries and so become trapped in heart muscle. Previously, radioactive or colored microspheres have quantified the number of tracers trapped in the muscle. Fluorescent microspheres offer a more recent and more sensitive measurement mode. However, fluorescent microspheres have not often been used to measure CBF in small animals (rats, mice) that are now the most common animal models used in heart research. This thesis aimed to develop the techniques for use of fluorescent microspheres to measure CBF in rat animal models used by the cell biology laboratories at UMDNJ-Newark. Two non-overlapping fluorescent wavelengths were chosen (yellow-green; red). Using a spectrophotometer, fluorescence intensity was calibrated for known numbers of microspheres (set via controlled dilution). CBF in two rats was measured at rest and during maximal vasodilation (adenosine) using procedures for colored microspheres. After euthanasia, hearts were removed, and blood samples and left ventricular tissue were processed using a sedimentation method for full recovery of fluorescent microspheres, which were scanned through the spectrophotometer to count fluorescence intensity. Using the predetermined calibration curve, the number of microspheres in each sample was determined; from this CBF was calculated. CBF averaged 5.9 ml/min/g at rest, which was within the normal range for rats quoted in recent literature. With maximal vasodilation, CBF increased to an average of 12.9 ml/min/g, which indicated a coronary flow reserve that was 2.2 times the resting level. The same value for coronary flow velocity reserve (2.2) was measured in 6 rats using Doppler echocardiography. The consistency of these results suggests that the procedures developed for fluorescent microspheres lead to repeatable and reliable measurement of coronary blood flow in rats. Advisors/Committee Members: William Corson Hunter, William C. Van Buskirk, Raquel Perez-Castillejos.

Subjects/Keywords: Coronary blood flow measurement; Fluorescent microspheres; Biomedical Engineering and Bioengineering

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APA (6^th Edition):

Shah, R. H. (2011). Use of fluorescent micropsheres to measure coronary flow reserve in rat animal model. (Thesis). New Jersey Institute of Technology. Retrieved from https://digitalcommons.njit.edu/theses/116

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Shah, Riddhi Harsh. “Use of fluorescent micropsheres to measure coronary flow reserve in rat animal model.” 2011. Thesis, New Jersey Institute of Technology. Accessed January 19, 2021. https://digitalcommons.njit.edu/theses/116.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Shah, Riddhi Harsh. “Use of fluorescent micropsheres to measure coronary flow reserve in rat animal model.” 2011. Web. 19 Jan 2021.

Vancouver:

Shah RH. Use of fluorescent micropsheres to measure coronary flow reserve in rat animal model. [Internet] [Thesis]. New Jersey Institute of Technology; 2011. [cited 2021 Jan 19]. Available from: https://digitalcommons.njit.edu/theses/116.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Shah RH. Use of fluorescent micropsheres to measure coronary flow reserve in rat animal model. [Thesis]. New Jersey Institute of Technology; 2011. Available from: https://digitalcommons.njit.edu/theses/116

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Michigan State University

7. Masin, Joseph George, 1944-. Blood rheology : proposed models and the effects of cation concentration and active hyperemia.

Degree: PhD, Department of Chemical Engineering, 1971, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:35420

Subjects/Keywords: Rheology (Biology); Blood flow – Measurement

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APA (6^th Edition):

Masin, Joseph George, 1. (1971). Blood rheology : proposed models and the effects of cation concentration and active hyperemia. (Doctoral Dissertation). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:35420

Chicago Manual of Style (16^th Edition):

Masin, Joseph George, 1944-. “Blood rheology : proposed models and the effects of cation concentration and active hyperemia.” 1971. Doctoral Dissertation, Michigan State University. Accessed January 19, 2021. http://etd.lib.msu.edu/islandora/object/etd:35420.

MLA Handbook (7^th Edition):

Masin, Joseph George, 1944-. “Blood rheology : proposed models and the effects of cation concentration and active hyperemia.” 1971. Web. 19 Jan 2021.

Vancouver:

Masin, Joseph George 1. Blood rheology : proposed models and the effects of cation concentration and active hyperemia. [Internet] [Doctoral dissertation]. Michigan State University; 1971. [cited 2021 Jan 19]. Available from: http://etd.lib.msu.edu/islandora/object/etd:35420.

Council of Science Editors:

Masin, Joseph George 1. Blood rheology : proposed models and the effects of cation concentration and active hyperemia. [Doctoral Dissertation]. Michigan State University; 1971. Available from: http://etd.lib.msu.edu/islandora/object/etd:35420

8. Griffith, Garett J. The prevalence of preclinical atherosclerosis in a healthy adult population.

Degree: Thesis (M.S.), 2014, Ball State University

URL: http://cardinalscholar.bsu.edu/handle/123456789/198124

► Cardiovascular disease (CVD) is a progressive disease that presents signs, such as abnormal thickening or stiffening of arteries, early in its preclinical stage, and screening… (more)

▼ Cardiovascular disease (CVD) is a progressive disease that presents signs, such as abnormal thickening or stiffening of arteries, early in its preclinical stage, and screening tools such as carotid intima media thickness (CIMT) measurement and pulse wave velocity (PWV) assessment have the potential to identify individuals prior to the clinical manifestation of CVD. The purpose of this study was to determine the prevalence of preclinical atherosclerosis, as indicated by high CIMT and PWV values, in an adult population aged 40-70 years and free of diagnosed CVD using these screening tools. Secondarily, this study aimed to compare established CVD risk factors and other health parameters between those with elevated or normal arterial health values. Sixty subjects made 2 visits to the Ball State University Human Performance Laboratory. The first visit included basic anthropometric measurements as well as assessment of CIMT and PWV. After a one week objective physical activity assessment, subjects returned to the HPL for assessment of blood lipids and body composition via dual energy x-ray absorptiometry scan. Prevalence of preclinical atherosclerosis was calculated from the total sample as well as within both genders, and an independent samples t-test was conducted in order to identify significant differences in health characteristics between those in the normal and high groups. Abnormal CIMT or PWV values were present in 43% of study subjects; 30% and 18% of the test sample met the criteria for elevated CIMT and PWV, respectively. Significant differences existed between normal and high CIMT and PWV study groups for physical activity, body composition, and blood lipid profile variables. Comparisons within each gender revealed differences in health profile elements. Both the CIMT and PWV measurement techniques may be valuable additions for community CVD screenings, as certain health profile abnormalities may impact each marker of arterial health differently. Additional research is needed in order to determine the cost-effectiveness of these screening tools as a preventive health method. Advisors/Committee Members: Kaminsky, Leonard A., 1955- (advisor).

Subjects/Keywords: Atherosclerosis – Early detection; Carotid artery; Blood flow – Measurement

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APA (6^th Edition):

Griffith, G. J. (2014). The prevalence of preclinical atherosclerosis in a healthy adult population. (Masters Thesis). Ball State University. Retrieved from http://cardinalscholar.bsu.edu/handle/123456789/198124

Chicago Manual of Style (16^th Edition):

Griffith, Garett J. “The prevalence of preclinical atherosclerosis in a healthy adult population.” 2014. Masters Thesis, Ball State University. Accessed January 19, 2021. http://cardinalscholar.bsu.edu/handle/123456789/198124.

MLA Handbook (7^th Edition):

Griffith, Garett J. “The prevalence of preclinical atherosclerosis in a healthy adult population.” 2014. Web. 19 Jan 2021.

Vancouver:

Griffith GJ. The prevalence of preclinical atherosclerosis in a healthy adult population. [Internet] [Masters thesis]. Ball State University; 2014. [cited 2021 Jan 19]. Available from: http://cardinalscholar.bsu.edu/handle/123456789/198124.

Council of Science Editors:

Griffith GJ. The prevalence of preclinical atherosclerosis in a healthy adult population. [Masters Thesis]. Ball State University; 2014. Available from: http://cardinalscholar.bsu.edu/handle/123456789/198124

Loughborough University

9. Franks, Peter J. Estimation of cardiac output by a single breath method.

Degree: PhD, 1985, Loughborough University

URL: http://hdl.handle.net/2134/32997

► Many attempts have been made to quantify cardiac output using both invasive and non-invasive techniques. The results have generally been poorly reproducible and comparisons of… (more)

Subjects/Keywords: 612; Blood flow measurement

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APA (6^th Edition):

Franks, P. J. (1985). Estimation of cardiac output by a single breath method. (Doctoral Dissertation). Loughborough University. Retrieved from http://hdl.handle.net/2134/32997

Chicago Manual of Style (16^th Edition):

Franks, Peter J. “Estimation of cardiac output by a single breath method.” 1985. Doctoral Dissertation, Loughborough University. Accessed January 19, 2021. http://hdl.handle.net/2134/32997.

MLA Handbook (7^th Edition):

Franks, Peter J. “Estimation of cardiac output by a single breath method.” 1985. Web. 19 Jan 2021.

Vancouver:

Franks PJ. Estimation of cardiac output by a single breath method. [Internet] [Doctoral dissertation]. Loughborough University; 1985. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2134/32997.

Council of Science Editors:

Franks PJ. Estimation of cardiac output by a single breath method. [Doctoral Dissertation]. Loughborough University; 1985. Available from: http://hdl.handle.net/2134/32997

University of Arizona

10. Diederich, Chris John, 1960-. THE IMPLEMENTATION AND EVALUATION OF TWO THERMAL TECHNIQUES FOR MEASURING LOCAL TISSUE PERFUSION .

Degree: 1986, University of Arizona

URL: http://hdl.handle.net/10150/277137

Subjects/Keywords: Blood flow – Measurement.; Blood – Circulation.; Materials – Thermal properties – Measurement.

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APA (6^th Edition):

Diederich, Chris John, 1. (1986). THE IMPLEMENTATION AND EVALUATION OF TWO THERMAL TECHNIQUES FOR MEASURING LOCAL TISSUE PERFUSION . (Masters Thesis). University of Arizona. Retrieved from http://hdl.handle.net/10150/277137

Chicago Manual of Style (16^th Edition):

Diederich, Chris John, 1960-. “THE IMPLEMENTATION AND EVALUATION OF TWO THERMAL TECHNIQUES FOR MEASURING LOCAL TISSUE PERFUSION .” 1986. Masters Thesis, University of Arizona. Accessed January 19, 2021. http://hdl.handle.net/10150/277137.

MLA Handbook (7^th Edition):

Diederich, Chris John, 1960-. “THE IMPLEMENTATION AND EVALUATION OF TWO THERMAL TECHNIQUES FOR MEASURING LOCAL TISSUE PERFUSION .” 1986. Web. 19 Jan 2021.

Vancouver:

Diederich, Chris John 1. THE IMPLEMENTATION AND EVALUATION OF TWO THERMAL TECHNIQUES FOR MEASURING LOCAL TISSUE PERFUSION . [Internet] [Masters thesis]. University of Arizona; 1986. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/10150/277137.

Council of Science Editors:

Diederich, Chris John 1. THE IMPLEMENTATION AND EVALUATION OF TWO THERMAL TECHNIQUES FOR MEASURING LOCAL TISSUE PERFUSION . [Masters Thesis]. University of Arizona; 1986. Available from: http://hdl.handle.net/10150/277137

Michigan State University

11. Meisel, Jayda Erkal. Investigating blood flow and antibiotic dosing using traditional microfluidics and novel 3D printed devices.

Degree: 2015, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:2756

► Over the last 25 years, it has been established that the red blood cell (RBC) is a major determinant in blood flow, which it can… (more)

▼ Over the last 25 years, it has been established that the red blood cell (RBC) is a major determinant in blood flow, which it can modulate through release of adenosine triphosphate (ATP). Although RBCs store intracellular ATP in mM concentrations, measurements indicate that the cells release nM concentrations when stimulated by deformation, hypoxia (lowered oxygen tension), or incubation with pharmacological stimuli such as hydroxyurea (HU), which is the only approved drug for treatment of sickle cell disease. Upon release, RBC-derived ATP can induce vessel dilation via activation of endothelial cell nitric oxide synthase (eNOS) to produce nitric oxide (NO). To probe the fate of increased ATP release from human RBCs incubated with the drug hydroxyurea, a traditional soft polymer platform was utilized to facilitate measurement of cell-to-cell communication between RBCs and a cultured endothelium. This device contained an array of micron-scale channels through which RBC samples were pumped. The sample flow was separated from a detection well by a porous polycarbonate membrane. Stimulated ATP released from the RBCs diffused across the membrane to the detection wells and was measured using the luciferin-luciferase chemiluminescence assay, integrated with a plate reader for detection. RBCs incubated with 100 uM of HU released on average 2.06 ± 0.37 times more ATP relative to the control sample. Through the use of various inhibitors, this increase in ATP release was subsequently demonstrated to depend on RBC deformability, RBC NOS activity, and the cystic fibrosis transmembrane conductance regulator protein (CFTR). The fate of the measured RBC-derived ATP was also investigated by probing ATP signalling to an adjacent cultured endothelium.ATP release from RBCs increases in response to hypoxia, or lowered oxygen tension; however, the dependence of RBC ATP release on oxygen tension has not been investigated. To enable measurement of RBC ATP release and oxygen tension in a flowing stream of RBCs, a 3D printed device was designed to accomodate commercial transwell inserts for ATP measurements, as well as threaded Clark-type electrodes for amperometric oxygen measurements. The device consisted of a channel 2 mm wide and 0.5 mm in height with two ports for analyte detection and one threaded port for an electrode. The Clark-type electrode was fabricated from gold and silver wires secured into a finger tight fitting. Oxygen standards and RBC samples were prepared using air and argon purged buffers. Using the 3D printed device, RBC ATP release and oxygen tension were measured simultaneously from prepared RBC samples. Relative to controls, RBC ATP release increased significantly in response to systematically lowered oxygen tension with a maximum increase of 2.38 ± 0.43 fold more ATP when exposed to 5.35 ± 0.12 ppm oxygen. ATP release saturated, i.e., was not significantly different, at lower oxygen tensions. This increase in ATP release was inhibited by incubating RBCs with the cell stiffening agent, diamide. The dependence of hypoxic… Advisors/Committee Members: Spence, Dana M, Jones, Arthur Dan, McCracken, John, Chan, Christina.

Subjects/Keywords: Blood flow – Measurement; Antibiotics; Drugs – Dosage; Microfluidic devices; Three-dimensional printing; Erythrocytes – Measurement; Adenosine triphosphate – Measurement; Chemistry; Physiology

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APA (6^th Edition):

Meisel, J. E. (2015). Investigating blood flow and antibiotic dosing using traditional microfluidics and novel 3D printed devices. (Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:2756

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Meisel, Jayda Erkal. “Investigating blood flow and antibiotic dosing using traditional microfluidics and novel 3D printed devices.” 2015. Thesis, Michigan State University. Accessed January 19, 2021. http://etd.lib.msu.edu/islandora/object/etd:2756.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Meisel, Jayda Erkal. “Investigating blood flow and antibiotic dosing using traditional microfluidics and novel 3D printed devices.” 2015. Web. 19 Jan 2021.

Vancouver:

Meisel JE. Investigating blood flow and antibiotic dosing using traditional microfluidics and novel 3D printed devices. [Internet] [Thesis]. Michigan State University; 2015. [cited 2021 Jan 19]. Available from: http://etd.lib.msu.edu/islandora/object/etd:2756.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Meisel JE. Investigating blood flow and antibiotic dosing using traditional microfluidics and novel 3D printed devices. [Thesis]. Michigan State University; 2015. Available from: http://etd.lib.msu.edu/islandora/object/etd:2756

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Alberta

12. Lalani, Akbar V. A. Echocardiographic determination of cardiac output using the echogram of the anterior mitral valve leaflet and aortic root and the relationship between the dynamics of mitral valve closure and aortic flow.

Degree: MSin Medicine, Department of Medicine, 1976, University of Alberta

URL: https://era.library.ualberta.ca/files/xk81jn77c

Subjects/Keywords: Mitral valve.; Cardiac output – Measurement.; Echocardiography.; Aorta.; Blood volume – Measurement.; Blood flow – Measurement.

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APA (6^th Edition):

Lalani, A. V. A. (1976). Echocardiographic determination of cardiac output using the echogram of the anterior mitral valve leaflet and aortic root and the relationship between the dynamics of mitral valve closure and aortic flow. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/xk81jn77c

Chicago Manual of Style (16^th Edition):

Lalani, Akbar V A. “Echocardiographic determination of cardiac output using the echogram of the anterior mitral valve leaflet and aortic root and the relationship between the dynamics of mitral valve closure and aortic flow.” 1976. Masters Thesis, University of Alberta. Accessed January 19, 2021. https://era.library.ualberta.ca/files/xk81jn77c.

MLA Handbook (7^th Edition):

Lalani, Akbar V A. “Echocardiographic determination of cardiac output using the echogram of the anterior mitral valve leaflet and aortic root and the relationship between the dynamics of mitral valve closure and aortic flow.” 1976. Web. 19 Jan 2021.

Vancouver:

Lalani AVA. Echocardiographic determination of cardiac output using the echogram of the anterior mitral valve leaflet and aortic root and the relationship between the dynamics of mitral valve closure and aortic flow. [Internet] [Masters thesis]. University of Alberta; 1976. [cited 2021 Jan 19]. Available from: https://era.library.ualberta.ca/files/xk81jn77c.

Council of Science Editors:

Lalani AVA. Echocardiographic determination of cardiac output using the echogram of the anterior mitral valve leaflet and aortic root and the relationship between the dynamics of mitral valve closure and aortic flow. [Masters Thesis]. University of Alberta; 1976. Available from: https://era.library.ualberta.ca/files/xk81jn77c

13. Barnett, Nicholas James. The development of biomedical instrumentation using backscattered laser light.

Degree: PhD, 1990, Oxford Brookes University

URL: https://radar.brookes.ac.uk/radar/items/854b71a4-e72a-4396-bac2-df2608345d2d/1 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278082

► This thesis is concerned with the measurement of blood flow and oxygen saturation in the microcirculation using the techniques of laser Doppler flowmetry and pulse… (more)

▼ This thesis is concerned with the measurement of blood flow and oxygen saturation in the microcirculation using the techniques of laser Doppler flowmetry and pulse oximetry. An investigation of the responses of Doppler flowmeters using different signal processing bandwidths and laser sources revealed two major findings. Firstly, that careful choice of processing bandwidth is required in order to sample the whole range of possible Doppler frequencies present in the backscattered light. Secondly, that the choice of laser source is important in governing the output stability of a flowmeter. Another investigation focused on the evaluation of a dual channel laser Doppler flowmeter using both in vitro and in vivo models. It was demonstrated that the instrument permitted a useful method of obtaining flow information by comparing simultaneous responses at experimental and control sites. The choice of laser wavelength was investigated in a study to determine whether blood flow measurements are obtained from different depths within the skin tissue. The results indicate that some depth discrimination is obtainable using instruments operating at different wavelengths, however it is difficult to demonstrate the effect in vivo. In a separate study it was shown that pressure applied to the skin surface greatly affects the underlying blood flow. It is recommended that care has to be taken when positioning Doppler probes on the skin. A reflection pulse oximeter was developed using laser light backscattered from the skin. The instrument was evaluated in vitro and in vivo by comparing desaturation responses with a commercial transmission pulse oximeter. The reflection oximeter was demonstrated to reliably follow trends in oxygen saturation but several problems prevented instrument calibration. Finally, a device combining laser Doppler flowmetry with reflection pulse oximetry was developed and used in vivo to follow trends in blood flow and oxygen saturation from the same tissue sample.

Subjects/Keywords: 610.28; Blood flow measurement in man

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APA (6^th Edition):

Barnett, N. J. (1990). The development of biomedical instrumentation using backscattered laser light. (Doctoral Dissertation). Oxford Brookes University. Retrieved from https://radar.brookes.ac.uk/radar/items/854b71a4-e72a-4396-bac2-df2608345d2d/1 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278082

Chicago Manual of Style (16^th Edition):

Barnett, Nicholas James. “The development of biomedical instrumentation using backscattered laser light.” 1990. Doctoral Dissertation, Oxford Brookes University. Accessed January 19, 2021. https://radar.brookes.ac.uk/radar/items/854b71a4-e72a-4396-bac2-df2608345d2d/1 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278082.

MLA Handbook (7^th Edition):

Barnett, Nicholas James. “The development of biomedical instrumentation using backscattered laser light.” 1990. Web. 19 Jan 2021.

Vancouver:

Barnett NJ. The development of biomedical instrumentation using backscattered laser light. [Internet] [Doctoral dissertation]. Oxford Brookes University; 1990. [cited 2021 Jan 19]. Available from: https://radar.brookes.ac.uk/radar/items/854b71a4-e72a-4396-bac2-df2608345d2d/1 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278082.

Council of Science Editors:

Barnett NJ. The development of biomedical instrumentation using backscattered laser light. [Doctoral Dissertation]. Oxford Brookes University; 1990. Available from: https://radar.brookes.ac.uk/radar/items/854b71a4-e72a-4396-bac2-df2608345d2d/1 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278082

University of Alberta

14. Soenen, Gary M. Regional gastric mucosal blood flow in man.

Degree: MS, Department of Medicine, 1990, University of Alberta

URL: https://era.library.ualberta.ca/files/bn999860g

Subjects/Keywords: Blood flow – Measurement.; Laser Doppler blood flowmetry.; Regional blood flow.

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APA (6^th Edition):

Soenen, G. M. (1990). Regional gastric mucosal blood flow in man. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/bn999860g

Chicago Manual of Style (16^th Edition):

Soenen, Gary M. “Regional gastric mucosal blood flow in man.” 1990. Masters Thesis, University of Alberta. Accessed January 19, 2021. https://era.library.ualberta.ca/files/bn999860g.

MLA Handbook (7^th Edition):

Soenen, Gary M. “Regional gastric mucosal blood flow in man.” 1990. Web. 19 Jan 2021.

Vancouver:

Soenen GM. Regional gastric mucosal blood flow in man. [Internet] [Masters thesis]. University of Alberta; 1990. [cited 2021 Jan 19]. Available from: https://era.library.ualberta.ca/files/bn999860g.

Council of Science Editors:

Soenen GM. Regional gastric mucosal blood flow in man. [Masters Thesis]. University of Alberta; 1990. Available from: https://era.library.ualberta.ca/files/bn999860g

University of Alberta

15. Gana, Theophilus Jones. Laser-Doppler flowmetry and hydrogen gas clearance comparison and applications in the measurement of focal gastric mucosal blood flow.

Degree: PhD, Department of Surgery, 1992, University of Alberta

URL: https://era.library.ualberta.ca/files/m900nw083

Subjects/Keywords: Blood flow – Measurement.; Laser Doppler blood flowmetry.

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APA (6^th Edition):

Gana, T. J. (1992). Laser-Doppler flowmetry and hydrogen gas clearance comparison and applications in the measurement of focal gastric mucosal blood flow. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/m900nw083

Chicago Manual of Style (16^th Edition):

Gana, Theophilus Jones. “Laser-Doppler flowmetry and hydrogen gas clearance comparison and applications in the measurement of focal gastric mucosal blood flow.” 1992. Doctoral Dissertation, University of Alberta. Accessed January 19, 2021. https://era.library.ualberta.ca/files/m900nw083.

MLA Handbook (7^th Edition):

Gana, Theophilus Jones. “Laser-Doppler flowmetry and hydrogen gas clearance comparison and applications in the measurement of focal gastric mucosal blood flow.” 1992. Web. 19 Jan 2021.

Vancouver:

Gana TJ. Laser-Doppler flowmetry and hydrogen gas clearance comparison and applications in the measurement of focal gastric mucosal blood flow. [Internet] [Doctoral dissertation]. University of Alberta; 1992. [cited 2021 Jan 19]. Available from: https://era.library.ualberta.ca/files/m900nw083.

Council of Science Editors:

Gana TJ. Laser-Doppler flowmetry and hydrogen gas clearance comparison and applications in the measurement of focal gastric mucosal blood flow. [Doctoral Dissertation]. University of Alberta; 1992. Available from: https://era.library.ualberta.ca/files/m900nw083

University of Arizona

16. Dodd, Laurie Rose. Arteriolar network responses to opposing dilator and constrictor stimuli: Mechanism of sympathetic attenuation during muscle contraction.

Degree: 1988, University of Arizona

URL: http://hdl.handle.net/10150/184572

► Evidence suggests different sections of the arteriolar network supplying muscle can respond independently and this may provide a mechanism for the localized distribution of blood… (more)

▼ Evidence suggests different sections of the arteriolar network supplying muscle can respond independently and this may provide a mechanism for the localized distribution of blood flow. This hypothesis was tested in the microcirculation of the cat sartorius muscle by measurement of arteriolar diameter changes during muscle contraction and sympathetic nerve stimulation in each consecutive section of the network. The diameter changes were referenced to the initial distribution of resistance across the network, as determined from arteriolar pressure measurements and morphometric data. This led to an estimate of the change in network resistance. Unlike previous reports, the most distal arterioles dilated little during muscle contraction and our resistance estimate indicates these vessels play an insignificant role in functional hyperemia. The more proximal, third order arterioles dilated proportionately more than other arteriolar orders and made the largest single contribution to resting resistance. Similarly, these vessels were the largest single site of resistance change during sympathetic stimulation. Together, these findings suggest the third order arterioles play a dominant role in regulating flow to the capillaries that each supplies. Antagonism of sympathetic control during muscle contraction has been attributed to direct inhibition of vascular smooth muscle contraction and to inhibition of sympathetic neurotransmission. Evidence to support the latter mechanism comes from the observation that functional dilation is reduced with exogenous norepinephrine as compared to sympathetic stimulation. However, exogenous norepinephrine may bind to both alpha-1 and alpha-2 adrenergic receptors, whereas that released by sympathetic stimulation may bind primarily to alpha-1 receptors. Since this difference could be significant, functional dilation after systemic injection of norepinephrine or phenylephrine, a selective alpha-1 agonist, was compared to that during sympathetic stimulation. In contrast to the findings with norepinephrine, functional dilation after phenylephrine did not differ from that observed during sympathetic stimulation. This indicates the dilator substance(s) released during exercise may selectively inhibit alpha-1 mediated vasoconstriction but less effectively inhibit vasoconstriction mediated by alpha-2 receptors. Furthermore, these findings suggest that the vasodilator mechanism may act primarily at the level of the vascular smooth muscle, without appreciable pre-junctional inhibition of sympathetic nerves. Advisors/Committee Members: Johnson, Paul C (advisor), Seals, Douglas R. (committeemember), Kreulen, David L. (committeemember), Secomb, Timothy W. (committeemember), Hasan, Ziaul (committeemember).

Subjects/Keywords: Regional blood flow – Measurement.; Microcirculation – Measurement.; Muscle contraction.

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APA (6^th Edition):

Dodd, L. R. (1988). Arteriolar network responses to opposing dilator and constrictor stimuli: Mechanism of sympathetic attenuation during muscle contraction. (Doctoral Dissertation). University of Arizona. Retrieved from http://hdl.handle.net/10150/184572

Chicago Manual of Style (16^th Edition):

Dodd, Laurie Rose. “Arteriolar network responses to opposing dilator and constrictor stimuli: Mechanism of sympathetic attenuation during muscle contraction. ” 1988. Doctoral Dissertation, University of Arizona. Accessed January 19, 2021. http://hdl.handle.net/10150/184572.

MLA Handbook (7^th Edition):

Dodd, Laurie Rose. “Arteriolar network responses to opposing dilator and constrictor stimuli: Mechanism of sympathetic attenuation during muscle contraction. ” 1988. Web. 19 Jan 2021.

Vancouver:

Dodd LR. Arteriolar network responses to opposing dilator and constrictor stimuli: Mechanism of sympathetic attenuation during muscle contraction. [Internet] [Doctoral dissertation]. University of Arizona; 1988. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/10150/184572.

Council of Science Editors:

Dodd LR. Arteriolar network responses to opposing dilator and constrictor stimuli: Mechanism of sympathetic attenuation during muscle contraction. [Doctoral Dissertation]. University of Arizona; 1988. Available from: http://hdl.handle.net/10150/184572

Michigan State University

17. De Olinger, Michael. Ultrasonic blood flow imaging using correlation processing.

Degree: PhD, Dept. of Electrical Engineering and Systems Science, 1981, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:10471

Subjects/Keywords: Blood flow – Measurement; Flow meters; Ultrasonics in medicine

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APA (6^th Edition):

De Olinger, M. (1981). Ultrasonic blood flow imaging using correlation processing. (Doctoral Dissertation). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:10471

Chicago Manual of Style (16^th Edition):

De Olinger, Michael. “Ultrasonic blood flow imaging using correlation processing.” 1981. Doctoral Dissertation, Michigan State University. Accessed January 19, 2021. http://etd.lib.msu.edu/islandora/object/etd:10471.

MLA Handbook (7^th Edition):

De Olinger, Michael. “Ultrasonic blood flow imaging using correlation processing.” 1981. Web. 19 Jan 2021.

Vancouver:

De Olinger M. Ultrasonic blood flow imaging using correlation processing. [Internet] [Doctoral dissertation]. Michigan State University; 1981. [cited 2021 Jan 19]. Available from: http://etd.lib.msu.edu/islandora/object/etd:10471.

Council of Science Editors:

De Olinger M. Ultrasonic blood flow imaging using correlation processing. [Doctoral Dissertation]. Michigan State University; 1981. Available from: http://etd.lib.msu.edu/islandora/object/etd:10471

University of Alberta

18. Knudsen, Knud Steven. Fluid flow measurement using NMR imaging.

Degree: MS, Department of Applied Sciences in Medicine, 1987, University of Alberta

URL: https://era.library.ualberta.ca/files/37720f75b

Subjects/Keywords: Blood flow – Mathematical models.; Magnetic resonance imaging.; Blood flow – Measurement.; Fluid dynamic measurements.

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APA (6^th Edition):

Knudsen, K. S. (1987). Fluid flow measurement using NMR imaging. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/37720f75b

Chicago Manual of Style (16^th Edition):

Knudsen, Knud Steven. “Fluid flow measurement using NMR imaging.” 1987. Masters Thesis, University of Alberta. Accessed January 19, 2021. https://era.library.ualberta.ca/files/37720f75b.

MLA Handbook (7^th Edition):

Knudsen, Knud Steven. “Fluid flow measurement using NMR imaging.” 1987. Web. 19 Jan 2021.

Vancouver:

Knudsen KS. Fluid flow measurement using NMR imaging. [Internet] [Masters thesis]. University of Alberta; 1987. [cited 2021 Jan 19]. Available from: https://era.library.ualberta.ca/files/37720f75b.

Council of Science Editors:

Knudsen KS. Fluid flow measurement using NMR imaging. [Masters Thesis]. University of Alberta; 1987. Available from: https://era.library.ualberta.ca/files/37720f75b

University of Missouri – Kansas City

19. Timpson, Erik Joseph. Experimental evaluation of intravascular flow meter and miniature RFID antennas using MEMS pressure sensors and flexible PCD techniques.

Degree: 2012, University of Missouri – Kansas City

URL: http://hdl.handle.net/10355/12471

► A testbed for flow meters was built and validated. The testbed targeted intravascular pressure and flow monitoring applications. The testbed consists of a data acquisition… (more)

Subjects/Keywords: Blood flow – Measurement; Radio frequency identification systems; Microelectromechanical systems; Thesis – University of Missouri – Kansas City – Engineering

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APA (6^th Edition):

Timpson, E. J. (2012). Experimental evaluation of intravascular flow meter and miniature RFID antennas using MEMS pressure sensors and flexible PCD techniques. (Thesis). University of Missouri – Kansas City. Retrieved from http://hdl.handle.net/10355/12471

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Timpson, Erik Joseph. “Experimental evaluation of intravascular flow meter and miniature RFID antennas using MEMS pressure sensors and flexible PCD techniques.” 2012. Thesis, University of Missouri – Kansas City. Accessed January 19, 2021. http://hdl.handle.net/10355/12471.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Timpson, Erik Joseph. “Experimental evaluation of intravascular flow meter and miniature RFID antennas using MEMS pressure sensors and flexible PCD techniques.” 2012. Web. 19 Jan 2021.

Vancouver:

Timpson EJ. Experimental evaluation of intravascular flow meter and miniature RFID antennas using MEMS pressure sensors and flexible PCD techniques. [Internet] [Thesis]. University of Missouri – Kansas City; 2012. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/10355/12471.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Timpson EJ. Experimental evaluation of intravascular flow meter and miniature RFID antennas using MEMS pressure sensors and flexible PCD techniques. [Thesis]. University of Missouri – Kansas City; 2012. Available from: http://hdl.handle.net/10355/12471

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

New Jersey Institute of Technology

20. Sinusas, Robert Rimvydas. Design and analysis of an instrument system for rheological testing of whole blood samples.

Degree: Doctor of Engineering Science in Mechanical Engineering, Mechanical Engineering, 1974, New Jersey Institute of Technology

URL: https://digitalcommons.njit.edu/dissertations/1299

► The dissertation covers the conceptual design of a rheometer for testing whole blood samples through to the clotting state. While the design aims at… (more)

Subjects/Keywords: Rheology (Biology); Blood flow – Measurement.; Hemodynamics; Mechanical Engineering

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APA (6^th Edition):

Sinusas, R. R. (1974). Design and analysis of an instrument system for rheological testing of whole blood samples. (Thesis). New Jersey Institute of Technology. Retrieved from https://digitalcommons.njit.edu/dissertations/1299

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sinusas, Robert Rimvydas. “Design and analysis of an instrument system for rheological testing of whole blood samples.” 1974. Thesis, New Jersey Institute of Technology. Accessed January 19, 2021. https://digitalcommons.njit.edu/dissertations/1299.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sinusas, Robert Rimvydas. “Design and analysis of an instrument system for rheological testing of whole blood samples.” 1974. Web. 19 Jan 2021.

Vancouver:

Sinusas RR. Design and analysis of an instrument system for rheological testing of whole blood samples. [Internet] [Thesis]. New Jersey Institute of Technology; 1974. [cited 2021 Jan 19]. Available from: https://digitalcommons.njit.edu/dissertations/1299.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sinusas RR. Design and analysis of an instrument system for rheological testing of whole blood samples. [Thesis]. New Jersey Institute of Technology; 1974. Available from: https://digitalcommons.njit.edu/dissertations/1299

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Edinburgh

21. Tao, Yuehui. Undersampling to accelerate time-resolved MRI velocity measurement of carotid blood flow.

Degree: PhD, 2009, University of Edinburgh

URL: http://hdl.handle.net/1842/4210

► Time-resolved velocity information of carotid blood flow can be used to estimate haemodynamic conditions associated with carotid artery disease leading to stroke. MRI provides high-resolution… (more)

▼ Time-resolved velocity information of carotid blood flow can be used to estimate haemodynamic conditions associated with carotid artery disease leading to stroke. MRI provides high-resolution measurement of such information but long scan time limits its clinical application in this area. In order to reduce scan time the MRI signal is often undersampled by skipping part of the signal during data acquisition. The aim of this work is to implement and evaluate different undersampling techniques for carotid velocity measurement on a 1.5 T clinical scanner. Most recent undersampling techniques assume spatial and temporal redundancies of real time-resolved MRI signal. In these techniques different undersampling strategies were proposed. Prior information or different assumptions of the nature of true signal were used in signal reconstruction. A brief review of these techniques and details of a representative technique, known as k-t BLAST, are presented. Another undersampling scheme, termed ktVD, is proposed to use predesigned undersampling patterns with variable sampling densities in both temporal and spatial dimensions. It aims to collect enough signal content at the signal acquisition stage and simplify signal reconstruction. Fidelity of the results from undersampled data is affected by many factors, such as signal dynamic content, degree of signal redundancy, noise level, degree of undersampling, undersampling patterns, and parameters of post-processing algorithms. Simulations and in vivo scans were conducted to investigate the effects of these factors in time-resolved 2D scans and time-resolved 3D scans. The results suggested velocity measurement became less reliable when they were obtained from less than 25% of the full signal. In time-resolved 3D scans the signal can be undersampled in either one or two spatial dimensions in addition to the temporal dimension. This allows more options in the design of undersampling patterns, which were tested in vivo. In order to test undersampling in three dimensions in high resolution 3D scans and measure velocity in three dimensions, a flow phantom was also scanned at high degrees of undersampling to test the proposed method.

Subjects/Keywords: 615.84; carotid blood flow; velocity measurement; MRI; undersampling

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APA (6^th Edition):

Tao, Y. (2009). Undersampling to accelerate time-resolved MRI velocity measurement of carotid blood flow. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/4210

Chicago Manual of Style (16^th Edition):

Tao, Yuehui. “Undersampling to accelerate time-resolved MRI velocity measurement of carotid blood flow.” 2009. Doctoral Dissertation, University of Edinburgh. Accessed January 19, 2021. http://hdl.handle.net/1842/4210.

MLA Handbook (7^th Edition):

Tao, Yuehui. “Undersampling to accelerate time-resolved MRI velocity measurement of carotid blood flow.” 2009. Web. 19 Jan 2021.

Vancouver:

Tao Y. Undersampling to accelerate time-resolved MRI velocity measurement of carotid blood flow. [Internet] [Doctoral dissertation]. University of Edinburgh; 2009. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/1842/4210.

Council of Science Editors:

Tao Y. Undersampling to accelerate time-resolved MRI velocity measurement of carotid blood flow. [Doctoral Dissertation]. University of Edinburgh; 2009. Available from: http://hdl.handle.net/1842/4210

University of Missouri – Columbia

22. Akers, Walter John, 1975-. Flourescent molecular rotors as mechanosensors in biofluids.

Degree: PhD, 2005, University of Missouri – Columbia

URL: https://doi.org/10.32469/10355/4114

► Many disease states have associated blood viscosity changes. Molecular rotors, fluorescent molecules with viscosity sensitive quantum yields, have recently been investigated as a new method… (more)

Subjects/Keywords: Blood – Viscosity; Biomechanics; Body fluid flow – Measurement

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APA (6^th Edition):

Akers, Walter John, 1. (2005). Flourescent molecular rotors as mechanosensors in biofluids. (Doctoral Dissertation). University of Missouri – Columbia. Retrieved from https://doi.org/10.32469/10355/4114

Chicago Manual of Style (16^th Edition):

Akers, Walter John, 1975-. “Flourescent molecular rotors as mechanosensors in biofluids.” 2005. Doctoral Dissertation, University of Missouri – Columbia. Accessed January 19, 2021. https://doi.org/10.32469/10355/4114.

MLA Handbook (7^th Edition):

Akers, Walter John, 1975-. “Flourescent molecular rotors as mechanosensors in biofluids.” 2005. Web. 19 Jan 2021.

Vancouver:

Akers, Walter John 1. Flourescent molecular rotors as mechanosensors in biofluids. [Internet] [Doctoral dissertation]. University of Missouri – Columbia; 2005. [cited 2021 Jan 19]. Available from: https://doi.org/10.32469/10355/4114.

Council of Science Editors:

Akers, Walter John 1. Flourescent molecular rotors as mechanosensors in biofluids. [Doctoral Dissertation]. University of Missouri – Columbia; 2005. Available from: https://doi.org/10.32469/10355/4114

University of Arizona

23. McVeigh, Lawrence James. Tissue perfusion analysis through photoplethysmic methods .

Degree: 1979, University of Arizona

URL: http://hdl.handle.net/10150/557323

Subjects/Keywords: Blood flow – Measurement.; Medical instruments and apparatus.

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APA (6^th Edition):

McVeigh, L. J. (1979). Tissue perfusion analysis through photoplethysmic methods . (Masters Thesis). University of Arizona. Retrieved from http://hdl.handle.net/10150/557323

Chicago Manual of Style (16^th Edition):

McVeigh, Lawrence James. “Tissue perfusion analysis through photoplethysmic methods .” 1979. Masters Thesis, University of Arizona. Accessed January 19, 2021. http://hdl.handle.net/10150/557323.

MLA Handbook (7^th Edition):

McVeigh, Lawrence James. “Tissue perfusion analysis through photoplethysmic methods .” 1979. Web. 19 Jan 2021.

Vancouver:

McVeigh LJ. Tissue perfusion analysis through photoplethysmic methods . [Internet] [Masters thesis]. University of Arizona; 1979. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/10150/557323.

Council of Science Editors:

McVeigh LJ. Tissue perfusion analysis through photoplethysmic methods . [Masters Thesis]. University of Arizona; 1979. Available from: http://hdl.handle.net/10150/557323

California State University – Northridge

24. Paler, John Ivan. Perivascular electromagnetic blood flow measurement.

Degree: MS, Department of Engineering, 1980, California State University – Northridge

URL: http://hdl.handle.net/10211.3/128516

► This thesis presents a study of an approach toward the measurement of blood flow in human subjects undergoing physiological evaluation. In the first part of… (more)

Subjects/Keywords: Blood flow – Measurement; Dissertations, Academic – CSUN – Engineering

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APA (6^th Edition):

Paler, J. I. (1980). Perivascular electromagnetic blood flow measurement. (Masters Thesis). California State University – Northridge. Retrieved from http://hdl.handle.net/10211.3/128516

Chicago Manual of Style (16^th Edition):

Paler, John Ivan. “Perivascular electromagnetic blood flow measurement.” 1980. Masters Thesis, California State University – Northridge. Accessed January 19, 2021. http://hdl.handle.net/10211.3/128516.

MLA Handbook (7^th Edition):

Paler, John Ivan. “Perivascular electromagnetic blood flow measurement.” 1980. Web. 19 Jan 2021.

Vancouver:

Paler JI. Perivascular electromagnetic blood flow measurement. [Internet] [Masters thesis]. California State University – Northridge; 1980. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/10211.3/128516.

Council of Science Editors:

Paler JI. Perivascular electromagnetic blood flow measurement. [Masters Thesis]. California State University – Northridge; 1980. Available from: http://hdl.handle.net/10211.3/128516

Georgia Tech

25. Karolyi, Daniel Roberts. Hemodynamic wall shear stress in models of atherosclerotic plaques using phase contrast magnetic resonance velocimetry and computational fluid dynamics.

Degree: PhD, Biomedical engineering, 2002, Georgia Tech

URL: http://hdl.handle.net/1853/20132

Subjects/Keywords: Heart valves Surgery; Blood flow Measurement; Fluid dynamics

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APA (6^th Edition):

Karolyi, D. R. (2002). Hemodynamic wall shear stress in models of atherosclerotic plaques using phase contrast magnetic resonance velocimetry and computational fluid dynamics. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/20132

Chicago Manual of Style (16^th Edition):

Karolyi, Daniel Roberts. “Hemodynamic wall shear stress in models of atherosclerotic plaques using phase contrast magnetic resonance velocimetry and computational fluid dynamics.” 2002. Doctoral Dissertation, Georgia Tech. Accessed January 19, 2021. http://hdl.handle.net/1853/20132.

MLA Handbook (7^th Edition):

Karolyi, Daniel Roberts. “Hemodynamic wall shear stress in models of atherosclerotic plaques using phase contrast magnetic resonance velocimetry and computational fluid dynamics.” 2002. Web. 19 Jan 2021.

Vancouver:

Karolyi DR. Hemodynamic wall shear stress in models of atherosclerotic plaques using phase contrast magnetic resonance velocimetry and computational fluid dynamics. [Internet] [Doctoral dissertation]. Georgia Tech; 2002. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/1853/20132.

Council of Science Editors:

Karolyi DR. Hemodynamic wall shear stress in models of atherosclerotic plaques using phase contrast magnetic resonance velocimetry and computational fluid dynamics. [Doctoral Dissertation]. Georgia Tech; 2002. Available from: http://hdl.handle.net/1853/20132

Macquarie University

26. Nadort, Annemarie. Glow with the flow: quantifying blood flow and photoluminescence signal in biological tissue.

Degree: 2015, Macquarie University

URL: http://hdl.handle.net/1959.14/1069512

►

Thesis by publication.

"this thesis is being submitted for examination simultaneously to Macquarie University and the University of Amsterdam under a co-tutelle co-supervision agreement between… (more)

▼

Thesis by publication.

"this thesis is being submitted for examination simultaneously to Macquarie University and the University of Amsterdam under a co-tutelle co-supervision agreement between the two universities".

Chapter 1. General introduction – Chapter 2. Laser speckle contrast imaging – Chapter 3. Quantitative laser speckle flowmetry of the in vivo microcirculation using sidestream dark field (microscopy) – Chapter 4. Quantitative blood flow velocity imaging using laser speckle flowmetry – Chapter 5. Upconversion nanoparticles – Chapter 6. Quantitative imaging of single upconversion nanoparticles in biological tissue – Chapter 7. Feasibility study of the optical imaging of a breast cancer lesion labeled with upconversion nanoparticle biocomplexes – Chapter 8. Discussion and conclusion – Chapter 9. Outlook.

This thesis contributes to the development of optical techniques to assess microcirculation functionality for the diagnosis, monitoring, therapy guidance and understanding of many diseases ranging from the onset of septic shock to the delivery of drugs to tumours. The first part of this thesis aims to develop a non-invasive technique to quantify microcirculatory blood flow velocity based on laser speckle flowmetry. The key results are the experimental and theoretical investigation of the characteristic decorrelation times of speckle dynamics, and the relationship with the flow velocity and optical propeerties of the scatterers, specifically multiple scattering in blood vessels and the scattering phase function of red blood cells. The second part is devoted to the quantification of optical signals arising from photluminescent upconversion nanoparticles (UCNPs) for sensitive detection in biomedical tissues. The key results demonstrate that the UCNP optical properties enable the detection of small amounts of particles in UCNP-guided imaging applications, ranging from the detection of a single nanoparticle in biological liquid to modelling of a small UCNP-labelled tumour lesion embedded in biological tissue. The combination of these techniques is particularly useful in the context of tumour therapy by providing information on tumour angiogenesis, enabling molecular contrast and delivering nanoparticle-based drugs.

1 online resource (197 pages) illustrations (some colour)

Advisors/Committee Members: Macquarie University. Department of Physics and Astronomy, Universiteit van Amsterdam.

Subjects/Keywords: Blood flow – Measurement; Laser speckle; Microcirculation; Nanoparticles – Therapeutic use; Microcirculation; biophotonics; microscopy; spectroscopy; laser speckle flowmetry; nanoparticles; upconversion; photoluminescence; biological tissue

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Nadort, A. (2015). Glow with the flow: quantifying blood flow and photoluminescence signal in biological tissue. (Doctoral Dissertation). Macquarie University. Retrieved from http://hdl.handle.net/1959.14/1069512

Chicago Manual of Style (16^th Edition):

Nadort, Annemarie. “Glow with the flow: quantifying blood flow and photoluminescence signal in biological tissue.” 2015. Doctoral Dissertation, Macquarie University. Accessed January 19, 2021. http://hdl.handle.net/1959.14/1069512.

MLA Handbook (7^th Edition):

Nadort, Annemarie. “Glow with the flow: quantifying blood flow and photoluminescence signal in biological tissue.” 2015. Web. 19 Jan 2021.

Vancouver:

Nadort A. Glow with the flow: quantifying blood flow and photoluminescence signal in biological tissue. [Internet] [Doctoral dissertation]. Macquarie University; 2015. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/1959.14/1069512.

Council of Science Editors:

Nadort A. Glow with the flow: quantifying blood flow and photoluminescence signal in biological tissue. [Doctoral Dissertation]. Macquarie University; 2015. Available from: http://hdl.handle.net/1959.14/1069512

University of New South Wales

27. Nugent, Allen Harold. Fluid dynamical investigation of a ventricular assist device.

Degree: Graduate School of Biomedical Engineering, 2005, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/35035 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:2091/SOURCE01?view=true

► The Spiral Vortex (SV) ventricular assist device (VAD) was investigated by 2-component laser Doppler anemometry (LDA) while pumping a refractive index-matched blood analogue fluid. The… (more)

▼ The Spiral Vortex (SV) ventricular assist device (VAD) was investigated by 2-component laser Doppler anemometry (LDA) while pumping a refractive index-matched blood analogue fluid. The VAD was operated under physiological conditions corresponding to 75% assist (4 litres/minute) or weaning from assist (2 litres/minute). Data were sampled on a 5-mm grid throughout most of the interior of the blood chamber, using two orthogonal LDA configurations from which 3D velocity data were synthesised.Data were subjected to statistical analysis of quasistatic time intervals and approximation by Fourier series. The velocity vector fields were explored statically (via 2D plots) and dynamically (using 3D animations of the reduced data). Reynolds stresses were computed and visualised in 2D. Fluid pathlines were simulated and plotted in 3D.The flow was found to be dominated by an irrotational vortex that accelerated and precessed in phase with the pumping diaphragm. Two unexpected flow structures, a rising, swirling near-wall layer in diastole and a reflection of the outflow vortex upon valve closure, enhanced washing of the walls. The thickness of the boundary layer was estimated to be 2 mm. Fluid velocities were generally lower than those reported in steady-flow studies on the SV VAD, although turbulence was comparable.Under the weaning mode, the coherence of the main vortex was degraded and flow recirculation was observed distal to the inflow port; this operating mode must be regarded as an indication for anticoagulation. In both pumping modes, turbulence was elevated in association with asymmetric buckling of the pneumatically driven diaphragm.Suboptimal orientation of the tilting-disc inlet valve gave rise to augmented turbulence production and skewing of the main vortex; similar results were obtained for an axisymmetric polymer (Jellyfish) valve, despite its advantageous haemodynamics. Flow stagnation was apparent where the inflow stream impinged on the wall, opposite the inflow port. The overall design of the SV VAD appears to almost ideal, in the context of current technology. However, elimination of recirculation/stagnation zones, especially in the weaning mode, remains a priority for the ultimate optimisation of haemocompatibility. Pulsatile VADs will probably never be entirely free of flow recirculation or stagnation, and published claims to the contrary probably reflect study limitations.

Subjects/Keywords: Blood flow; Measurement; Heart Artificial; Artificial heart

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APA (6^th Edition):

Nugent, A. H. (2005). Fluid dynamical investigation of a ventricular assist device. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/35035 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:2091/SOURCE01?view=true

Chicago Manual of Style (16^th Edition):

Nugent, Allen Harold. “Fluid dynamical investigation of a ventricular assist device.” 2005. Doctoral Dissertation, University of New South Wales. Accessed January 19, 2021. http://handle.unsw.edu.au/1959.4/35035 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:2091/SOURCE01?view=true.

MLA Handbook (7^th Edition):

Nugent, Allen Harold. “Fluid dynamical investigation of a ventricular assist device.” 2005. Web. 19 Jan 2021.

Vancouver:

Nugent AH. Fluid dynamical investigation of a ventricular assist device. [Internet] [Doctoral dissertation]. University of New South Wales; 2005. [cited 2021 Jan 19]. Available from: http://handle.unsw.edu.au/1959.4/35035 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:2091/SOURCE01?view=true.

Council of Science Editors:

Nugent AH. Fluid dynamical investigation of a ventricular assist device. [Doctoral Dissertation]. University of New South Wales; 2005. Available from: http://handle.unsw.edu.au/1959.4/35035 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:2091/SOURCE01?view=true

University of Texas – Austin

28. Santos, Icaro dos. In vivo measurements of the heat convection coefficient on the endocardial surface.

Degree: PhD, Electrical and Computer Engineering, 2003, University of Texas – Austin

URL: http://hdl.handle.net/2152/911

► This work describes the fundamentals, calibration procedure and in vivo results of an instrument for the measurement of the heat convection coefficient between the endocardium… (more)

Subjects/Keywords: Heat – Convection; Blood flow – Measurement; Catheter ablation

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APA (6^th Edition):

Santos, I. d. (2003). In vivo measurements of the heat convection coefficient on the endocardial surface. (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/911

Chicago Manual of Style (16^th Edition):

Santos, Icaro dos. “In vivo measurements of the heat convection coefficient on the endocardial surface.” 2003. Doctoral Dissertation, University of Texas – Austin. Accessed January 19, 2021. http://hdl.handle.net/2152/911.

MLA Handbook (7^th Edition):

Santos, Icaro dos. “In vivo measurements of the heat convection coefficient on the endocardial surface.” 2003. Web. 19 Jan 2021.

Vancouver:

Santos Id. In vivo measurements of the heat convection coefficient on the endocardial surface. [Internet] [Doctoral dissertation]. University of Texas – Austin; 2003. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2152/911.

Council of Science Editors:

Santos Id. In vivo measurements of the heat convection coefficient on the endocardial surface. [Doctoral Dissertation]. University of Texas – Austin; 2003. Available from: http://hdl.handle.net/2152/911

29. Khavulya, Dmitry, 1980-. Rapid monitoring of brain auditory evoked potentials for assessing cerebral hypoxia.

Degree: MS, Biomedical Engineering, 2012, Rutgers University

URL: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000065171

► The brain is critically dependent on blood flow and oxygen supply for its normal function. Few existing methods allow rapid noninvasive assessment during critical hypoxic… (more)

Subjects/Keywords: Blood flow – Measurement; Auditory evoked response; Brain

…Background Electroencephalography is the measurement of aggregate electrical activity generated in… …however the voltage gradient is mostly governed by the flow of Na+, K+, and Cl- ions. At rest…

10 more images…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Khavulya, Dmitry, 1. (2012). Rapid monitoring of brain auditory evoked potentials for assessing cerebral hypoxia. (Masters Thesis). Rutgers University. Retrieved from http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000065171

Chicago Manual of Style (16^th Edition):

Khavulya, Dmitry, 1980-. “Rapid monitoring of brain auditory evoked potentials for assessing cerebral hypoxia.” 2012. Masters Thesis, Rutgers University. Accessed January 19, 2021. http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000065171.

MLA Handbook (7^th Edition):

Khavulya, Dmitry, 1980-. “Rapid monitoring of brain auditory evoked potentials for assessing cerebral hypoxia.” 2012. Web. 19 Jan 2021.

Vancouver:

Khavulya, Dmitry 1. Rapid monitoring of brain auditory evoked potentials for assessing cerebral hypoxia. [Internet] [Masters thesis]. Rutgers University; 2012. [cited 2021 Jan 19]. Available from: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000065171.

Council of Science Editors:

Khavulya, Dmitry 1. Rapid monitoring of brain auditory evoked potentials for assessing cerebral hypoxia. [Masters Thesis]. Rutgers University; 2012. Available from: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000065171

30. Wei, Datong. Quantitative and continuous measurement of cerebral blood flow by a thermal method.

Degree: PhD, Biomedical Engineering, 1993, Case Western Reserve University School of Graduate Studies

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1060354210

► A thermal perfusion system is developed to measure cerebral blood flow continuously and quantitatively, with thermistors placed on brain surface to minimize tissue damage. Heat… (more)

▼ A thermal perfusion system is developed to measure cerebral blood flow continuously and quantitatively, with thermistors placed on brain surface to minimize tissue damage. Heat transfer models for tissue and self-heated thermistor are used to compare sensitivity, resolution and dynamic response under different operating modes and boundary conditions. Simulation results indicate that large perfusion sensitivity requires large thermistor while fast dynamic response calls for small thermistor. Adiabatic condition at the tissue-environment interface can maximize perfusion sensitivity and minimize thermal interference. Theoretical framework for optimal probe and system design based on measurement requirements has been established through the steady-state relations between thermal output and perfusion. The system, with lock-in amplifiers and a thermistor for reference temperature, can detect temperature signal of 0.001°C caused by perfusion changes while accommodating baseline temperature variations on the order of 0.1°C. The perfusion sensitivity and dynamic response are tested in vitro and in vivo. Noise analysis indicates that thermal fluctuations in tissue and environment are much larger than electrical noise and are the major error source. Perfusion changes associated with arterial blood pressure changes caused by bolus norepinephrine injections are used to validate the system output during continuous heating. In vivo evaluation demonstrates that the dynamic response is adequate to follow transient perfusion changes before autoregulation and perfusion cycling around 0.1 Hz. A partial analytical solution of the heat transfer model is developed, resulting consistent relations between transient and continuous heating modes. Model parameters including perfusion are estimated by nonlinear least-squares fitting from the temperature response during transient heating. A calibration coefficient is obtained from the estimated parameters without varying perfusion at different levels. Continuous perfusion changes can be quantified from the thermal output during continuous heating using the calibration coefficient. Estimated perfusion resolution of the system is about 1 mL/100g-min. Practical procedures to estimate the frequency response of thermal system have been developed for the first time. Animal experiments show that perfusion estimates from the thermal and the quantitative autoradiographic techniques are correlated. CO₂ reactivity test demonstrates the sensitivity of the quantitative procedure of the thermal method to perfusion changes Advisors/Committee Members: Saidel, Gerald (Advisor).

Subjects/Keywords: Engineering, Biomedical; Cerebral blood flow, measurement; Thermal method

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wei, D. (1993). Quantitative and continuous measurement of cerebral blood flow by a thermal method. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1060354210

Chicago Manual of Style (16^th Edition):

Wei, Datong. “Quantitative and continuous measurement of cerebral blood flow by a thermal method.” 1993. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed January 19, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1060354210.

MLA Handbook (7^th Edition):

Wei, Datong. “Quantitative and continuous measurement of cerebral blood flow by a thermal method.” 1993. Web. 19 Jan 2021.

Vancouver:

Wei D. Quantitative and continuous measurement of cerebral blood flow by a thermal method. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 1993. [cited 2021 Jan 19]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1060354210.

Council of Science Editors:

Wei D. Quantitative and continuous measurement of cerebral blood flow by a thermal method. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 1993. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1060354210

Open Access Theses and Dissertations