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University of Melbourne
1.
Gradie, Paul Edward.
Defining the master regulator of urethral closure in mouse.
Degree: 2017, University of Melbourne
URL: http://hdl.handle.net/11343/198127 
► Hypospadias is the ectopic placement of the urethral opening on the underside of the penis and is one of the most common developmental abnormalities in…
(more)
▼ Hypospadias is the ectopic placement of the urethral opening on the underside of the penis and is one of the most common developmental abnormalities in humans, occurring in approximately 1 in every 125 live male births. In addition, we have observed a doubling in the incidence of hypospadias over the past several decades suggesting an environmental component likely in the form of estrogen mimicking chemicals generally referred to as environmental endocrine disruptors (EEDs). Current models fail to explain these observations. The goal of this thesis is to produce a theory that describes the development and genetic regulation of urethral closure, and use it to explain the aetiology, spectrum, and rise in incidence of hypospadias observed in humans.
The work presented in this thesis was performed using a novel mouse model (OVE442) with isolated hypospadias. This model was used to define the role of the urorectal septum (URS) during urethral closure. The process of urethral closure is generally thought to occur by tissue fusion. However, we provide immunohistological evidence that suggests the urethra is internalized by growth of the URS, which contributes tissue to the ventral aspect of the penis during embryonic development. The OVE442 model was next used to define a key regulator of the URS during urethral closure. Initial characterization of a genomic mutation in OVE442 model led us to discover a long non-coding RNA, designated Leat1, which was deleted near EfnB2. Loss of signalling through the EPHRINB2 protein was previously shown to cause severe hypospadias in mouse, however little is known about EfnB2 gene regulation during urethral closure. Leat1 was characterized, functionally examined, and shown to regulate EfnB2 expression through direct interaction with the EPHRINB2 protein. We further showed that Leat1 expression is differentially regulated in males and females, and that it is supressed by estrogen. These results showed that EfnB2 drives growth of the URS during urethral closure and provided the first experimental evidence revealing the genetic mechanism that causes male and female urethral anatomy to diverge. These observations were used together with our anatomical descriptions to produce a developmental theory that explains urethral formation in mouse. We extended our understanding further by using comparative time series RNA-Seq to describe global transcription and ChIP-Seq to identify genes actively regulated by estrogen and androgen during urethral. From these data, we identify potential urethral closure genes downstream of Leat1 and EfnB2 including genes that are likely responsive to sex hormones.
This work has provided fundamental insights on the anatomy and genetic regulation of urethral closure. I have shown that male urethral closure is driven by growth of the URS and that this growth is regulated by the long non-coding RNA Leat1 in mouse. Furthermore, I have produced a list of potential EED targets that may lead to better understanding the causes of hypospadias. Through this work I have…
Subjects/Keywords: hypospadias; long non coding RNA; development; reproduction; urethra; urogenital; birth defect
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APA (6th Edition):
Gradie, P. E. (2017). Defining the master regulator of urethral closure in mouse. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/198127
Chicago Manual of Style (16th Edition):
Gradie, Paul Edward. “Defining the master regulator of urethral closure in mouse.” 2017. Doctoral Dissertation, University of Melbourne. Accessed January 16, 2021.
http://hdl.handle.net/11343/198127.
MLA Handbook (7th Edition):
Gradie, Paul Edward. “Defining the master regulator of urethral closure in mouse.” 2017. Web. 16 Jan 2021.
Vancouver:
Gradie PE. Defining the master regulator of urethral closure in mouse. [Internet] [Doctoral dissertation]. University of Melbourne; 2017. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/11343/198127.
Council of Science Editors:
Gradie PE. Defining the master regulator of urethral closure in mouse. [Doctoral Dissertation]. University of Melbourne; 2017. Available from: http://hdl.handle.net/11343/198127
2.
Sibiude, Jeanne.
Tolérance maternelle et néonatale des antirétroviraux pendant la grossesse à l’ère des multithérapies : Maternal and Neonatal Tolerance of Antiretroviral Treatment During Pregnancy in the HAART Era.
Degree: Docteur es, Santé publique - épidémiologie, 2017, Université Paris-Saclay (ComUE)
URL: http://www.theses.fr/2017SACLS050
► L’objectif de cette thèse était d’étudier les associations potentielles entre les traitements antirétroviraux reçus par les femmes enceintes infectées par le VIH et les complications…
(more)
▼ L’objectif de cette thèse était d’étudier les associations potentielles entre les traitements antirétroviraux reçus par les femmes enceintes infectées par le VIH et les complications pouvant survenir au cours de la grossesse ou être diagnostiquées dans la période néonatale. Ce travail est issu en majeure partie des données de l’Enquête Périnatale Française (ANRS-EPF), cohorte nationale multicentrique ayant inclus plus de 20 000 couples mères-enfants depuis 1986. Actuellement, presque toutes les femmes sont traitées par combinaisons antirétrovirales puissantes (cART ; 98% en 2013) et le taux de transmission est inférieur à 1% : 0.6% (IC95% : 0.4%-0.8% pour la période 2005-2013). La première partie portait sur le risque d’accouchement prématuré dont le taux a augmenté significativement entre la période 1990-1993 et 2005-2009, passant de 9.2% à 14.3%. Le risque d’accouchement prématuré était significativement associé au traitement par cART, par rapport aux monothérapies et bithérapies d’INTI, et au traitement débuté avant la conception par rapport aux traitements débutés en cours de grossesse. La survenue d’une cytolyse hépatique était fréquente (17%), et était liée à la fois à la prématurité, et au type de traitement, plus fréquentes avec les IP qu’avec les inhibiteurs non nucléosidiques de la transcriptase inverse. La perturbation du bilan hépatique pourrait être un facteur intermédiaire dans la relation entre traitements et accouchement prématuré. La seconde partie portait sur les malformations congénitales. D’une part, elle a permis de mettre en évidence une association entre exposition à l’efavirenz au premier trimestre de grossesse et les malformations neurologiques, bien que concernant peu de cas (n=4) et n’atteignant la significativité que dans une analyse de sensibilité. Cette association incite à maintenir une vigilance chez les enfants exposés in utero à cette molécule classée tératogène par la FDA mais prescrite de plus en plus largement. D’autre part, l’exposition au premier trimestre à la zidovudine était associée à la survenue de malformations cardiaques. La troisième partie a complété cette étude par une analyse de la fonction cardiaque, des modifications infracliniques de la contractilité et de l’épaisseur des parois du ventricule gauche ont été mises en évidence chez les enfants exposés in utero à une combinaison de traitement contenant la zidovudine et la lamivudine. Ces résultats ne remettent pas en question l’efficacité majeure des traitements antirétroviraux pour la prévention de la transmission de la mère à l’enfant du VIH, mais incitent à la poursuite d’une surveillance épidémiologique des effets indésirables potentiels, de manière à optimiser les prescriptions pour un meilleur rapport bénéfice/risque.
Our objective was to study potential associations between antiretroviral treatment and obstetrical or neonatal complications in a population of HIV-positive pregnant women. Most of the analyses were conducted with data from the French Perinatal Cohort (ANRS-EPF), an ongoing multicenter national…
Advisors/Committee Members: Warszawski, Josiane (thesis director), Mandelbrot, Laurent (thesis director).
Subjects/Keywords: VIH; Grossesse; Prématurité; Malformations; PTME; Antirétroviraux; HIV; Pregnancy; Preterm birth; Congenital birth defect; PMTCT; Antiretroviral treatment
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APA ·
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APA (6th Edition):
Sibiude, J. (2017). Tolérance maternelle et néonatale des antirétroviraux pendant la grossesse à l’ère des multithérapies : Maternal and Neonatal Tolerance of Antiretroviral Treatment During Pregnancy in the HAART Era. (Doctoral Dissertation). Université Paris-Saclay (ComUE). Retrieved from http://www.theses.fr/2017SACLS050
Chicago Manual of Style (16th Edition):
Sibiude, Jeanne. “Tolérance maternelle et néonatale des antirétroviraux pendant la grossesse à l’ère des multithérapies : Maternal and Neonatal Tolerance of Antiretroviral Treatment During Pregnancy in the HAART Era.” 2017. Doctoral Dissertation, Université Paris-Saclay (ComUE). Accessed January 16, 2021.
http://www.theses.fr/2017SACLS050.
MLA Handbook (7th Edition):
Sibiude, Jeanne. “Tolérance maternelle et néonatale des antirétroviraux pendant la grossesse à l’ère des multithérapies : Maternal and Neonatal Tolerance of Antiretroviral Treatment During Pregnancy in the HAART Era.” 2017. Web. 16 Jan 2021.
Vancouver:
Sibiude J. Tolérance maternelle et néonatale des antirétroviraux pendant la grossesse à l’ère des multithérapies : Maternal and Neonatal Tolerance of Antiretroviral Treatment During Pregnancy in the HAART Era. [Internet] [Doctoral dissertation]. Université Paris-Saclay (ComUE); 2017. [cited 2021 Jan 16].
Available from: http://www.theses.fr/2017SACLS050.
Council of Science Editors:
Sibiude J. Tolérance maternelle et néonatale des antirétroviraux pendant la grossesse à l’ère des multithérapies : Maternal and Neonatal Tolerance of Antiretroviral Treatment During Pregnancy in the HAART Era. [Doctoral Dissertation]. Université Paris-Saclay (ComUE); 2017. Available from: http://www.theses.fr/2017SACLS050
University of the Western Cape
3.
Mohammednur, Mohammedmekin Mohammedseid.
Adverse pregnancy outcomes among HIV-positive pregnant women treated with efavirenz-containing antiretroviral drugs: a retrospective cohort study in the Cape Flats
.
Degree: 2017, University of the Western Cape
URL: http://hdl.handle.net/11394/6185
► The use of efavirenz (EFV) in the first trimester of pregnancy remains controversial. In South Africa, the use of EFV-containing antiretroviral therapy (ART) as part…
(more)
▼ The use of efavirenz (EFV) in the first trimester of pregnancy
remains controversial. In South Africa, the use of EFV-containing antiretroviral
therapy (ART) as part of a Fixed Dose Combination (FDC) during the first
trimester of pregnancy started in April, 2013. Literature to date has reported
conflicting outcomes following the use of EFV-containing ART during the first
trimester of pregnancy. The objectives of the study were to determine the
prevalence of adverse pregnancy outcomes among HIV-positive pregnant women
treated with EFV-containing ART and compare these results with those of pregnant
women treated with NVP-containing ART and HIV-negative pregnant women in
resource-limited settings. In addition, the study also aimed to determine the effect
of the time of initiation of ART on the prevalence of adverse pregnancy outcomes.
Advisors/Committee Members: Mugabo, Pierre (advisor).
Subjects/Keywords: Adverse pregnancy outcomes;
Antiretroviral drug;
Birth defect;
Efavirenz;
First trimester;
HIV;
Low birth weight;
Nevirapine;
Pregnant women;
Preterm delivery
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APA (6th Edition):
Mohammednur, M. M. (2017). Adverse pregnancy outcomes among HIV-positive pregnant women treated with efavirenz-containing antiretroviral drugs: a retrospective cohort study in the Cape Flats
. (Thesis). University of the Western Cape. Retrieved from http://hdl.handle.net/11394/6185
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Mohammednur, Mohammedmekin Mohammedseid. “Adverse pregnancy outcomes among HIV-positive pregnant women treated with efavirenz-containing antiretroviral drugs: a retrospective cohort study in the Cape Flats
.” 2017. Thesis, University of the Western Cape. Accessed January 16, 2021.
http://hdl.handle.net/11394/6185.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Mohammednur, Mohammedmekin Mohammedseid. “Adverse pregnancy outcomes among HIV-positive pregnant women treated with efavirenz-containing antiretroviral drugs: a retrospective cohort study in the Cape Flats
.” 2017. Web. 16 Jan 2021.
Vancouver:
Mohammednur MM. Adverse pregnancy outcomes among HIV-positive pregnant women treated with efavirenz-containing antiretroviral drugs: a retrospective cohort study in the Cape Flats
. [Internet] [Thesis]. University of the Western Cape; 2017. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/11394/6185.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Mohammednur MM. Adverse pregnancy outcomes among HIV-positive pregnant women treated with efavirenz-containing antiretroviral drugs: a retrospective cohort study in the Cape Flats
. [Thesis]. University of the Western Cape; 2017. Available from: http://hdl.handle.net/11394/6185
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of South Florida
4.
Ramakrishnan, Rema.
Ambient Ozone and Cadmium as Risk Factors For Congenital Diaphragmatic Hernia.
Degree: 2017, University of South Florida
URL: https://scholarcommons.usf.edu/etd/7439
► Congenital diaphragmatic hernia (CDH) results from a defect in the diaphragm through which abdominal contents enter the thorax displacing the heart and the lungs. This…
(more)
▼ Congenital diaphragmatic hernia (CDH) results from a defect in the diaphragm through which abdominal contents enter the thorax displacing the heart and the lungs. This causes lung hypoplasia and varying degrees of pulmonary hypertension resulting in high rates of morbidity and mortality. Though CDH has a prevalence rate of 2.61 per 10,000 live births it is an expensive birth defect with an estimated annual cost of nearly $250 million for all CDH survivors. Maternal exposure to air pollutants have not been studied as risk factors for CDH in humans. Ambient ozone has been found to be risk factors for certain birth defects including congenital heart defects, chromosomal anomalies, and limb reduction defects. Cadmium, however, has been found to be a risk factor for diaphragmatic hernia, cleft palate, renal defects, anopthalmia, microphthalmia, anal atresia, undescended testes, and dysplastic ears in animal studies only. The objectives of this study were to: 1) examine the prevalence, temporal trends, and correlates of CDH among live-born infants during 1998–2012; 2) investigate the association between sociodemographic and perinatal characteristics and neonatal and one-year survival among infants with CDH and its subtypes, isolated and complex; 3) examine the role of ambient ozone as a risk factor for CDH; and 4) determine the association between maternal exposure to ambient cadmium in air and CDH and assess if maternal smoking during pregnancy is an effect modifier of the cadmium-CDH association. To answer these questions we used a population-based, retrospective cohort study using data from the 1998–2012 Florida Birth Defects Registry. We classified CDH cases into isolated and complex. A case that was associated with other anomalies listed on the National Birth Defects Prevention Network list of major structural reportable defects was classified as complex CDH. We used Poisson and joinpoint regression models to compute prevalence ratios and assess temporal trends, respectively. Kaplan-Meier survival curves and Cox proportional hazards regression were used to describe neonatal and one-year survival and estimate hazard ratios of neonatal and one-year mortality. We then used multilevel Poisson regression models to examine the association between maternal exposure to ambient ozone and CDH as well as cadmium and CDH. We conducted stratified analyses to test for effect measure modification by maternal smoking status. The study population to answer the first two questions consisted of 3,209,775 live-born infants (including 1,025 cases). To answer the third and fourth questions, the study population consisted of 3,039,685 and 2,591,395 live-born infants (including 981 and 840 cases), respectively. We found a 4% increase in the annual prevalence of CDH among complex cases, but no trend for isolated cases. We observed higher prevalence of CDH among infants born to mothers with high school or less maternal education and for multiple births. Female sex and maternal obesity were found to be associated with decreased risk for CDH.…
Subjects/Keywords: air pollution; ambient ozone; ambient cadmium; survival; epidemiology; musculoskeletal birth defect; Epidemiology; Public Health
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APA ·
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APA (6th Edition):
Ramakrishnan, R. (2017). Ambient Ozone and Cadmium as Risk Factors For Congenital Diaphragmatic Hernia. (Thesis). University of South Florida. Retrieved from https://scholarcommons.usf.edu/etd/7439
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Ramakrishnan, Rema. “Ambient Ozone and Cadmium as Risk Factors For Congenital Diaphragmatic Hernia.” 2017. Thesis, University of South Florida. Accessed January 16, 2021.
https://scholarcommons.usf.edu/etd/7439.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Ramakrishnan, Rema. “Ambient Ozone and Cadmium as Risk Factors For Congenital Diaphragmatic Hernia.” 2017. Web. 16 Jan 2021.
Vancouver:
Ramakrishnan R. Ambient Ozone and Cadmium as Risk Factors For Congenital Diaphragmatic Hernia. [Internet] [Thesis]. University of South Florida; 2017. [cited 2021 Jan 16].
Available from: https://scholarcommons.usf.edu/etd/7439.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Ramakrishnan R. Ambient Ozone and Cadmium as Risk Factors For Congenital Diaphragmatic Hernia. [Thesis]. University of South Florida; 2017. Available from: https://scholarcommons.usf.edu/etd/7439
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Freie Universität Berlin
5.
Linsenmeier, Verena.
Effects of diclofenac intake in early pregnancy – a cohort study of the Pharmakovigilance Centre Embryonaltoxikologie.
Degree: 2020, Freie Universität Berlin
URL: http://dx.doi.org/10.17169/refubium-27450
► Introduction: Diclofenac is often used to treat chronic inflammatory diseases and pain, so that early pregnancy exposure may occur. In previous studies on the effect…
(more)
▼ Introduction:
Diclofenac is often used to treat chronic inflammatory diseases and pain, so that early pregnancy exposure may occur. In previous studies on the effect of pain medication on the course of pregnancy, the effects of NSAIDs were mainly considered as a substance class.
The aim of this study was to improve drug safety in pregnancy by investigating the effects of systemic diclofenac exposure during the first trimester of pregnancy on the rate of
birth defects and on the occurrence of spontaneous abortions.
Methods:
For this cohort study, prospectively collected data of the German Embryotox institute were evaluated. 260 women who had taken diclofenac during the first trimester were compared with 778 women without diclofenac exposure. Using Cox regression cumulative incidences were calculated for the competing pregnancy outcomes live
birth, spontaneous abortion, elective termination of pregnancy and stillbirth. Total rates of
birth defects and frequencies of major
birth defects were calculated. The odds ratios were calculated using logistic regression and propensity score adjustment.
Results:
In the diclofenac cohort, four major
birth defects occurred in 220 live births. These were two malformations of the nervous system and two congenital heart defects, whereby one child was additionally affected by a kidney malformation. In the control cohort, 21 major
birth defects occurred in 677 cases, including one induced abortion and one spontaneous abortion with malformation. In total, 25 spontaneous abortions occurred in the exposed cohort and 65 in the comparison cohort. Neither the maternal nor newborn characteristics (e.g. preterm
birth, head circumference) were significantly different between cohorts. Neither the rate of major
birth defects (1.8% vs. 3.1%; ORadj 0.59; 95% CI 0.17-2.08) nor of spontaneous abortions (HRadj 0.90; 95% CI 0.56-1.46) were increased in the diclofenac cohort.
Conclusions:
In our study, there was no evidence that diclofenac intake in the first trimester of pregnancy is associated with a teratogenic or embryotoxic risk. Therefore, pregnant patients with early pregnancy exposure may be reassured. Further studies with larger sample size are needed to confirm our results.
Advisors/Committee Members: female (gender), N.N. (firstReferee), N.N. (furtherReferee).
Subjects/Keywords: Birth defect; Diclofenac; Non-steroidal anti-inflammatory drug (NSAID); Pregnancy outcome; Spontaneous abortion; ddc:610
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APA ·
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CSE |
Export
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Manager
APA (6th Edition):
Linsenmeier, V. (2020). Effects of diclofenac intake in early pregnancy – a cohort study of the Pharmakovigilance Centre Embryonaltoxikologie. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-27450
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Linsenmeier, Verena. “Effects of diclofenac intake in early pregnancy – a cohort study of the Pharmakovigilance Centre Embryonaltoxikologie.” 2020. Thesis, Freie Universität Berlin. Accessed January 16, 2021.
http://dx.doi.org/10.17169/refubium-27450.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Linsenmeier, Verena. “Effects of diclofenac intake in early pregnancy – a cohort study of the Pharmakovigilance Centre Embryonaltoxikologie.” 2020. Web. 16 Jan 2021.
Vancouver:
Linsenmeier V. Effects of diclofenac intake in early pregnancy – a cohort study of the Pharmakovigilance Centre Embryonaltoxikologie. [Internet] [Thesis]. Freie Universität Berlin; 2020. [cited 2021 Jan 16].
Available from: http://dx.doi.org/10.17169/refubium-27450.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Linsenmeier V. Effects of diclofenac intake in early pregnancy – a cohort study of the Pharmakovigilance Centre Embryonaltoxikologie. [Thesis]. Freie Universität Berlin; 2020. Available from: http://dx.doi.org/10.17169/refubium-27450
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
6.
Reyes, Maria R.
Women with Correctable Fetal Anomaly Participating in Perinatal Team Counseling: An Exploratory Study.
Degree: 2014, University of Illinois – Chicago
URL: http://hdl.handle.net/10027/19010
► Fetal anomalies are the second leading cause of infant death, and a major cause of long-term infant disability. Approximately 3% of U.S. births are complicated…
(more)
▼ Fetal anomalies are the second leading cause of infant death, and a major cause of long-term infant disability. Approximately 3% of U.S. births are complicated by major fetal anomalies. Advances in prenatal technologies, changes to universal screening standards, and changes in maternal characteristics have increased the likelihood of fetal anomaly detection. However, currently, we lack the research necessary to evaluate current intervention strategies used to assess what women need to effectively cope with the emotional turmoil that accompanies a prenatal diagnosis. Likened to a significantly traumatic life-event, women diagnosed with a fetal anomaly describe negative emotional responses such as anxiety, anger, and guilt, perceptions of inadequacy, social isolation, and grief-like reactions.
Perinatal and pediatric interdisciplinary team counseling, a novel approach to counseling women with a fetal anomaly, involves use of perinatal and pediatric sub-specialists gathered to discuss and counsel on a specific fetal condition; offering women an opportunity to meet with the perinatal and pediatric sub-specialist, obtain information of the fetal diagnosis, prognosis, and anticipated post-natal course. Using Lazarus and Folkman’s Stress, Appraisal and Coping framework, this research was intended to explore the perceptions of women diagnosed with a correctable fetal anomaly, who participated in perinatal and pediatric interdisciplinary team counseling. Described in chapter II is an exploration of the perceived effectiveness of this method of counseling, assessing the effects on maternal anxiety, effects on coping, knowledge of the fetal anomaly diagnosis and prognosis, with perceptions of provider sensitivity. An integrative review of the literature is described in chapter III.
A qualitative descriptive, semi-structured interview approach was used to explore the experiences of fourteen women, currently pregnant with a correctable fetal anomaly that completed interdisciplinary perinatal and pediatric interdisciplinary team counseling. Participants were recruited from a Midwest referral center, specializing in team counseling (Fetal Concerns Program of Wisconsin). Interviews were digitally recorded, transcribed verbatim and analyzed using content analysis.
This study’s descriptive findings support interdisciplinary team counseling in helping women facing a prenatal diagnosis. Nurses play a key role in this process. Joining specialties during one-day and multiple day sessions was positively accepted and helped women in their journey.
Advisors/Committee Members: Hershberger, Patricia (advisor), Norr, Kathleen (committee member), Dancy, Barbara (committee member), Leuthner, Steven (committee member), Kuhlmann, Randall (committee member), Giugescu, Carmen (committee member).
Subjects/Keywords: Keywords: birth defect; team counseling; woman’s response, pregnancy, qualitative research. Pub-med Mesh headings: Fetal Diseases / diagnosis non-directive counseling
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APA ·
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MLA ·
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CSE |
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to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Reyes, M. R. (2014). Women with Correctable Fetal Anomaly Participating in Perinatal Team Counseling: An Exploratory Study. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/19010
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Reyes, Maria R. “Women with Correctable Fetal Anomaly Participating in Perinatal Team Counseling: An Exploratory Study.” 2014. Thesis, University of Illinois – Chicago. Accessed January 16, 2021.
http://hdl.handle.net/10027/19010.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Reyes, Maria R. “Women with Correctable Fetal Anomaly Participating in Perinatal Team Counseling: An Exploratory Study.” 2014. Web. 16 Jan 2021.
Vancouver:
Reyes MR. Women with Correctable Fetal Anomaly Participating in Perinatal Team Counseling: An Exploratory Study. [Internet] [Thesis]. University of Illinois – Chicago; 2014. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/10027/19010.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Reyes MR. Women with Correctable Fetal Anomaly Participating in Perinatal Team Counseling: An Exploratory Study. [Thesis]. University of Illinois – Chicago; 2014. Available from: http://hdl.handle.net/10027/19010
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Freie Universität Berlin
7.
Padberg, Stephanie.
an analysis of the Embryotox database.
Degree: 2014, Freie Universität Berlin
URL: http://dx.doi.org/10.17169/refubium-7305
► Objectives: Bacterial infections need effective treatment during pregnancy because they are a hazard to the mother and the unborn child. Often the bacterial spectrum requires…
(more)
▼ Objectives: Bacterial infections need effective treatment during pregnancy
because they are a hazard to the mother and the unborn child. Often the
bacterial spectrum requires the use of second line agents, but there is
uncertainty concerning the risk for the unborn child. In animal experiments
juvenile cartilage damage was observed after postnatal fluoroquinolone
exposure. Therefore fluoroquinolones are generally avoided during pregnancy.
But increasing numbers of prescriptions have led to increasing exposure during
unplanned pregnancies. This study analyses the cumulative data of the
Pharmakovigilanz- und Beratungszentrum für Embryonaltoxikologie at the
Charité-Universitätsmedizin in order to contribute to the safety of this group
of antibiotics during pregnancy. Methods: We performed a prospective
observational cohort study of pregnancies exposed orally or intravenously to a
fluoroquinolone during the 1st trimester (until gestational week 12+6 after
last menstrual period). Pregnancy outcomes were compared to a cohort of
pregnant women who were neither exposed to fluoroquinolones nor a teratogenic
or fetotoxic drug. Both fluoroquinolone and control group were recruited from
the archive of the Pharmakovigilanz- und Beratungszentrum für
Embryonaltoxikologie. Outcomes evaluated were major
birth defects, spontaneous
abortion, gestational age at delivery, and
birth weight. Additionally we
looked for a distinct pattern of malformations, a substance-specific risk
among the fluoroquinolones, and a “teratogenic time window” within the 1st
trimester. Results: 949 pregnancies with systemic 1st trimester
fluoroquinolone-treatment were compared with 3.796 non-exposed pregnancies.
Neither the rate of major
birth defects (2.4% vs. 2.8%; OR 0.91; 95% CI
0.55–1.51) nor the risk of spontaneous abortion (10.2% vs. 8.2%; HR 1.01; 95%
CI 0.79–1.29) was increased. In the fluoroquinolone group more pregnancies
were electively terminated for personal reasons (9.9% vs. 6.1%; HR 1.32; 95%
CI 1.03–1.69). Gestational age at delivery and
birth weights did not differ
between groups. No specific pattern of malformations and no specific
teratogenic time window within the 1st trimester could be identified. In
association with moxifloxacin the rate of major
birth defects was increased
but did not reach significance (6.5%; OR 2.4; 95% CI 0.84–5.63). Conclusions:
Our study does not confirm an increased risk of adverse pregnancy outcome
after systemic fluoroquinolone therapy during the 1st trimester. The
reassuring findings support the recommendation to allow fluoroquinolone
prescription in pregnancy in selected cases of bacterial resistance or
intolerance against 1st line antibiotics. After 1st trimester use of
moxifloxacin a detailed fetal ultrasound examination should be offered to
ascertain the normal development of the fetus.
Advisors/Committee Members: [email protected] (contact), w (gender), N.N. (firstReferee), N.N. (furtherReferee).
Subjects/Keywords: fluoroquinolone; pregnancy; teratogen; spontaneous abortion; birth defect; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit
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APA (6th Edition):
Padberg, S. (2014). an analysis of the Embryotox database. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-7305
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Padberg, Stephanie. “an analysis of the Embryotox database.” 2014. Thesis, Freie Universität Berlin. Accessed January 16, 2021.
http://dx.doi.org/10.17169/refubium-7305.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Padberg, Stephanie. “an analysis of the Embryotox database.” 2014. Web. 16 Jan 2021.
Vancouver:
Padberg S. an analysis of the Embryotox database. [Internet] [Thesis]. Freie Universität Berlin; 2014. [cited 2021 Jan 16].
Available from: http://dx.doi.org/10.17169/refubium-7305.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Padberg S. an analysis of the Embryotox database. [Thesis]. Freie Universität Berlin; 2014. Available from: http://dx.doi.org/10.17169/refubium-7305
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Virginia Tech
8.
Laudermilch, Chelsea Lee.
Birth Defect Amelioration and Placental Cytokine Expression in Mnu-Exposed Dams Treated With Ifn-Gamma.
Degree: MS, Biomedical and Veterinary Sciences, 2007, Virginia Tech
URL: http://hdl.handle.net/10919/31046
► Each year, 7.9 million babies are born with birth defects. Seventy percent of those could be prevented, ameliorated, or repaired; yet 3.2 million children still…
(more)
▼ Each year, 7.9 million babies are born with
birth defects. Seventy percent of those could be prevented, ameliorated, or repaired; yet 3.2 million children still die by the age of three (March of Dimes Global Report 2006). We have found that non-specific maternal immune stimulation with the cytokine interferon-gamma (IFN-gamma) can successfully ameliorate some of these defects in the C57BL/6N mouse model. We have observed a reduction in the distal limb malformations syndactyly, polydactyly, and webbing by 47%, 100%, and 63% respectively when IFN-gamma is given 2 days prior to MNU administration. We have also observed that IFN-gamma works at the placental level to protect against MNU-induced damage. Trophoblast loss and associated cytokine alterations occur in gestation day (GD) 14 placenta following GD9 MNU exposure, showing that fetal-maternal communication can be hindered due to MNU. In the labyrinthine layer of the placenta, we observed multifocal fibrinous necrosis of endothelial cells due to MNU, however IFN-gamma almost completely protected the trophoblast and endothelial cells when given to the dam as an immune stimulant. To determine the genes participating in these processes, gene microarray studies were conducted. Hepatocyte growth factor (HGF), interleukin 1 beta (IL1Β), and insulin-like growth factor 2 (IGF2) were elucidated as genes that were significantly expressed in GD12 placenta. These genes are similar in that they are all connected to the Jak-Stat signaling pathway. These findings provide a possible mechanism for
birth defect reduction by maternal immune stimulation with IFN-gamma in MNU-challenged mice.
Advisors/Committee Members: Prater, Mary Renee (committeechair), Huckle, William R. (committee member), Holladay, Steven D. (committee member).
Subjects/Keywords: teratogenesis; IFN-gamma; cytokine; Birth defect; placenta
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APA (6th Edition):
Laudermilch, C. L. (2007). Birth Defect Amelioration and Placental Cytokine Expression in Mnu-Exposed Dams Treated With Ifn-Gamma. (Masters Thesis). Virginia Tech. Retrieved from http://hdl.handle.net/10919/31046
Chicago Manual of Style (16th Edition):
Laudermilch, Chelsea Lee. “Birth Defect Amelioration and Placental Cytokine Expression in Mnu-Exposed Dams Treated With Ifn-Gamma.” 2007. Masters Thesis, Virginia Tech. Accessed January 16, 2021.
http://hdl.handle.net/10919/31046.
MLA Handbook (7th Edition):
Laudermilch, Chelsea Lee. “Birth Defect Amelioration and Placental Cytokine Expression in Mnu-Exposed Dams Treated With Ifn-Gamma.” 2007. Web. 16 Jan 2021.
Vancouver:
Laudermilch CL. Birth Defect Amelioration and Placental Cytokine Expression in Mnu-Exposed Dams Treated With Ifn-Gamma. [Internet] [Masters thesis]. Virginia Tech; 2007. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/10919/31046.
Council of Science Editors:
Laudermilch CL. Birth Defect Amelioration and Placental Cytokine Expression in Mnu-Exposed Dams Treated With Ifn-Gamma. [Masters Thesis]. Virginia Tech; 2007. Available from: http://hdl.handle.net/10919/31046
University of Sydney
9.
Goldsmith, Shona.
Population studies of assisted reproductive technology and congenital anomalies in cerebral palsy
.
Degree: University of Sydney
URL: http://hdl.handle.net/2123/21909
► BACKGROUND: Risk factors for cerebral palsy (CP) have been identified across the conception, pregnancy, perinatal and postneonatal periods, including Assisted Reproductive Technology (ART) and congenital…
(more)
▼ BACKGROUND: Risk factors for cerebral palsy (CP) have been identified across the conception, pregnancy, perinatal and postneonatal periods, including Assisted Reproductive Technology (ART) and congenital anomalies. ART likely increases risk of CP through mediating factors including multiple and preterm birth, but this requires further investigation in Australia. While congenital anomalies are an identified risk factor for CP, their reported prevalence varies widely. This thesis describes the epidemiology of CP with respect to these two independent factors. METHODS: A series of population-based studies were conducted. The influence of ART on prevalence of CP and clinical outcomes in Western Australia was explored in a population-based data-linkage study. Population-based research describing congenital anomalies in CP was synthesised in a systematic literature review. The most common congenital anomaly in CP from the review, congenital microcephaly, was investigated in a Western Australian population case-control study. Finally, population data-linkages were conducted in Australia and Europe to examine major congenital anomalies and outcomes in children with pre/perinatally acquired CP and postneonatally acquired CP (PNN-CP). RESULTS: ART was associated with a two-fold increased risk of CP. While multiple and preterm births were common after ART, additional risk of CP existed for very preterm ART singletons. The systematic review identified congenital anomalies in 12–32% of children with pre/perinatal CP and 20% of PNN-CP. Children with CP had a three-fold risk of congenital microcephaly in the case-control study. In Australia and Europe, congenital anomalies were identified in approximately one in four children with CP. Isolated cerebral anomalies were most common in children with pre/perinatally acquired CP, and isolated cardiac anomalies in PNN-CP. Congenital anomalies were associated with more severe outcomes for children with pre/perinatally acquired CP, but not PNN-CP. CONCLUSION: ART and congenital anomalies are important factors in the epidemiology of CP, and opportunities for prevention may lie in these pathways to CP. Research is planned to: a) evaluate temporal trends in ART and CP in Australia and b) further elucidate pathways and risk of CP for children with specific anomalies.
Subjects/Keywords: birth defect;
epidemiology;
assisted reproductive technology;
congenital anomaly
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APA ·
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Export
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Manager
APA (6th Edition):
Goldsmith, S. (n.d.). Population studies of assisted reproductive technology and congenital anomalies in cerebral palsy
. (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/21909
Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Goldsmith, Shona. “Population studies of assisted reproductive technology and congenital anomalies in cerebral palsy
.” Thesis, University of Sydney. Accessed January 16, 2021.
http://hdl.handle.net/2123/21909.
Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Goldsmith, Shona. “Population studies of assisted reproductive technology and congenital anomalies in cerebral palsy
.” Web. 16 Jan 2021.
Note: this citation may be lacking information needed for this citation format:
No year of publication.
Vancouver:
Goldsmith S. Population studies of assisted reproductive technology and congenital anomalies in cerebral palsy
. [Internet] [Thesis]. University of Sydney; [cited 2021 Jan 16].
Available from: http://hdl.handle.net/2123/21909.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.
Council of Science Editors:
Goldsmith S. Population studies of assisted reproductive technology and congenital anomalies in cerebral palsy
. [Thesis]. University of Sydney; Available from: http://hdl.handle.net/2123/21909
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.
10.
Tercya Lúcidi de Araújo Silva.
Anticorpos anti-pestivírus em caprinos e ovinos do sertão do Estado de Pernambuco, Brasil.
Degree: 2009, Universidade Federal Rural de Pernambuco
URL: http://200.17.137.108/tde_busca/arquivo.php?codArquivo=715
► Um dos principais problemas sanitários observados na caprinovinocultura do Estado de Pernambuco é a ocorrência de abortamentos e de defeitos congênitos, que ocorrem de forma…
(more)
▼ Um dos principais problemas sanitários observados na caprinovinocultura do Estado de Pernambuco é a ocorrência de abortamentos e de defeitos congênitos, que ocorrem de forma endêmica nas criações. A etiologia desses distúrbios em pequenos ruminantes ainda não é totalmente esclarecida. Os Pestivírus ocorrem em bovinos em vários países, incluindo o Brasil, estado de Pernambuco. Para verificar o envolvimento dos Pestivírus como um dos potenciais participantes na etiologia dos abortamentos foi estimada, através de um inquérito soroepidemiológico, a sua prevalência em caprinos e ovinos criados no sertão Pernambucano, principal região produtora do estado. Para isto, foram submetidas ao teste de soroneutralização em microplaca, utilizando cepacitopatogênica de BVDV-1 (NADL), 814 amostras de soros caprinos e ovinos. A prevalência encontrada foi de 10,89% (9,36≤p≤12,42) em caprinos e 6,98 (5,36≤p≤8,60) em ovinos, não havendo diferença estatisticamente significativa (χ2, P>0,05) entre as espécies. As amostras foram estratificadas segundo a categoria animal (matriz, reprodutor ejovem) e mesorregião de onde as amostras eram procedentes (Sertão Pernambucano e Sertão do São Francisco Pernambucano), não apresentando diferença estatisticamente significativa (χ2, P>0,05) entre os estratos. De acordo com as informações disponibilizadas pelos criadores ou tratadores, o aborto ocorreu em 70,96% (22/31) das criações onde foi aplicado um questionário investigativo, e defeitos congênitos em 83,87% (26/31). Os defeitos congênitos mais frequentemente relatados foram: artrogripose de membros anteriores, posteriores e de cervical, agenesia de membros posteriores, ceguerira, microftalmia, agnatismo, prognatismo, lábio leporino e má formação da face. Adicionalmente foi informado que caprinos e ovinos são criados em conjunto com bovinos em 61,29% das criações. Pelos resultados obtidos pode-se concluir que os Pestivírus ocorrem em pequenos ruminantes, independente de idade e sexo, nos Sertões Pernambucano e do São Francisco Pernambucano, em baixa prevalência.
A major health problems seen in caprinovinocultura of Pernambuco is the occurrence of miscarriages and birth defects, occurring in an endemic form in the creations. The etiology of these disorders in small ruminants has not been fully resolved. The pestiviruses occur in cattle in several countries, including Brazil, Pernambuco state. To check the involvement of pestiviruses as one of the potential participants in the etiology of abortions was estimated, through a seroepidemiological survey, its prevalence in goats and sheep reared in the backwoods of Pernambuco State, the main producing region of the state. For this, were subjected to neutralization test in microplates, using strain-cytopathogenic BVDV-1 (NADL), 814 serum samples from goats and sheep. The prevalence was 10.89% (9.36 ≤ p ≤ 12.42) in goats and 6.98% (5.36 ≤ p ≤ 8.60) in sheep, with no statistically significant difference (χ2, P >0.05) between species. The samples…
Advisors/Committee Members: Roberto Soares de Castro, Andréa Alice da Fonseca Oliveira, Lúcio Esmeraldo Honorio de Melo, Miriam Nogueira Teixeira.
Subjects/Keywords: Soroneutralização; Diagnóstico; Ruminantes; Aborto; Defeitos congênitos; Caprinos; Ovinos; Pernambuco (BR); Diarréia viral bovina 5. Defeitos congênitos; MEDICINA VETERINARIA; Small ruminants; Neutralization; Bovine viral diarrhea virus; Border disease; Abortion; Birth defect
Record Details
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Record Details
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Silva, T. L. d. A. (2009). Anticorpos anti-pestivírus em caprinos e ovinos do sertão do Estado de Pernambuco, Brasil. (Thesis). Universidade Federal Rural de Pernambuco. Retrieved from http://200.17.137.108/tde_busca/arquivo.php?codArquivo=715
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Silva, Tercya Lúcidi de Araújo. “Anticorpos anti-pestivírus em caprinos e ovinos do sertão do Estado de Pernambuco, Brasil.” 2009. Thesis, Universidade Federal Rural de Pernambuco. Accessed January 16, 2021.
http://200.17.137.108/tde_busca/arquivo.php?codArquivo=715.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Silva, Tercya Lúcidi de Araújo. “Anticorpos anti-pestivírus em caprinos e ovinos do sertão do Estado de Pernambuco, Brasil.” 2009. Web. 16 Jan 2021.
Vancouver:
Silva TLdA. Anticorpos anti-pestivírus em caprinos e ovinos do sertão do Estado de Pernambuco, Brasil. [Internet] [Thesis]. Universidade Federal Rural de Pernambuco; 2009. [cited 2021 Jan 16].
Available from: http://200.17.137.108/tde_busca/arquivo.php?codArquivo=715.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Silva TLdA. Anticorpos anti-pestivírus em caprinos e ovinos do sertão do Estado de Pernambuco, Brasil. [Thesis]. Universidade Federal Rural de Pernambuco; 2009. Available from: http://200.17.137.108/tde_busca/arquivo.php?codArquivo=715
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
11.
Tercya Lúcidi de Araújo Silva.
Anticorpos anti-pestivírus em caprinos e ovinos do sertão do Estado de Pernambuco, Brasil.
Degree: 2009, Universidade Federal Rural de Pernambuco
URL: http://200.17.137.108/tde_busca/arquivo.php?codArquivo=715
► Um dos principais problemas sanitários observados na caprinovinocultura do Estado de Pernambuco é a ocorrência de abortamentos e de defeitos congênitos, que ocorrem de forma…
(more)
▼ Um dos principais problemas sanitários observados na caprinovinocultura do Estado de Pernambuco é a ocorrência de abortamentos e de defeitos congênitos, que ocorrem de forma endêmica nas criações. A etiologia desses distúrbios em pequenos ruminantes ainda não é totalmente esclarecida. Os Pestivírus ocorrem em bovinos em vários países, incluindo o Brasil, estado de Pernambuco. Para verificar o envolvimento dos Pestivírus como um dos potenciais participantes na etiologia dos abortamentos foi estimada, através de um inquérito soroepidemiológico, a sua prevalência em caprinos e ovinos criados no sertão Pernambucano, principal região produtora do estado. Para isto, foram submetidas ao teste de soroneutralização em microplaca, utilizando cepacitopatogênica de BVDV-1 (NADL), 814 amostras de soros caprinos e ovinos. A prevalência encontrada foi de 10,89% (9,36≤p≤12,42) em caprinos e 6,98 (5,36≤p≤8,60) em ovinos, não havendo diferença estatisticamente significativa (χ2, P>0,05) entre as espécies. As amostras foram estratificadas segundo a categoria animal (matriz, reprodutor ejovem) e mesorregião de onde as amostras eram procedentes (Sertão Pernambucano e Sertão do São Francisco Pernambucano), não apresentando diferença estatisticamente significativa (χ2, P>0,05) entre os estratos. De acordo com as informações disponibilizadas pelos criadores ou tratadores, o aborto ocorreu em 70,96% (22/31) das criações onde foi aplicado um questionário investigativo, e defeitos congênitos em 83,87% (26/31). Os defeitos congênitos mais frequentemente relatados foram: artrogripose de membros anteriores, posteriores e de cervical, agenesia de membros posteriores, ceguerira, microftalmia, agnatismo, prognatismo, lábio leporino e má formação da face. Adicionalmente foi informado que caprinos e ovinos são criados em conjunto com bovinos em 61,29% das criações. Pelos resultados obtidos pode-se concluir que os Pestivírus ocorrem em pequenos ruminantes, independente de idade e sexo, nos Sertões Pernambucano e do São Francisco Pernambucano, em baixa prevalência.
A major health problems seen in caprinovinocultura of Pernambuco is the occurrence of miscarriages and birth defects, occurring in an endemic form in the creations. The etiology of these disorders in small ruminants has not been fully resolved. The pestiviruses occur in cattle in several countries, including Brazil, Pernambuco state. To check the involvement of pestiviruses as one of the potential participants in the etiology of abortions was estimated, through a seroepidemiological survey, its prevalence in goats and sheep reared in the backwoods of Pernambuco State, the main producing region of the state. For this, were subjected to neutralization test in microplates, using strain-cytopathogenic BVDV-1 (NADL), 814 serum samples from goats and sheep. The prevalence was 10.89% (9.36 ≤ p ≤ 12.42) in goats and 6.98% (5.36 ≤ p ≤ 8.60) in sheep, with no statistically significant difference (χ2, P >0.05) between species. The samples…
Advisors/Committee Members: Roberto Soares de Castro, Andréa Alice da Fonseca Oliveira, Lúcio Esmeraldo Honorio de Melo, Miriam Nogueira Teixeira.
Subjects/Keywords: Soroneutralização; Diagnóstico; Ruminantes; Aborto; Defeitos congênitos; Caprinos; Ovinos; Pernambuco (BR); Diarréia viral bovina 5. Defeitos congênitos; MEDICINA VETERINARIA; Small ruminants; Neutralization; Bovine viral diarrhea virus; Border disease; Abortion; Birth defect
Record Details
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Record Details
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Silva, T. L. d. A. (2009). Anticorpos anti-pestivírus em caprinos e ovinos do sertão do Estado de Pernambuco, Brasil. (Thesis). Universidade Federal Rural de Pernambuco. Retrieved from http://200.17.137.108/tde_busca/arquivo.php?codArquivo=715
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Silva, Tercya Lúcidi de Araújo. “Anticorpos anti-pestivírus em caprinos e ovinos do sertão do Estado de Pernambuco, Brasil.” 2009. Thesis, Universidade Federal Rural de Pernambuco. Accessed January 16, 2021.
http://200.17.137.108/tde_busca/arquivo.php?codArquivo=715.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Silva, Tercya Lúcidi de Araújo. “Anticorpos anti-pestivírus em caprinos e ovinos do sertão do Estado de Pernambuco, Brasil.” 2009. Web. 16 Jan 2021.
Vancouver:
Silva TLdA. Anticorpos anti-pestivírus em caprinos e ovinos do sertão do Estado de Pernambuco, Brasil. [Internet] [Thesis]. Universidade Federal Rural de Pernambuco; 2009. [cited 2021 Jan 16].
Available from: http://200.17.137.108/tde_busca/arquivo.php?codArquivo=715.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Silva TLdA. Anticorpos anti-pestivírus em caprinos e ovinos do sertão do Estado de Pernambuco, Brasil. [Thesis]. Universidade Federal Rural de Pernambuco; 2009. Available from: http://200.17.137.108/tde_busca/arquivo.php?codArquivo=715
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Freie Universität Berlin
12.
Weber-Schöndorfer, Corinna.
Specification of the risk profile of selected immunomodulatory drugs during
pregnancy.
Degree: 2016, Freie Universität Berlin
URL: http://dx.doi.org/10.17169/refubium-6399
► Drug treatment of pregnant women is still a subject of uncertainty. Rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis and also inflammatory bowel disease often occur…
(more)
▼ Drug treatment of pregnant women is still a
subject of uncertainty. Rheumatoid
arthritis, systemic lupus erythematosus, multiple sclerosis and also
inflammatory bowel disease often occur in reproductive age. Therefore,
diseased women, who want to become pregnant, as well as their physicians would
like to know which medical therapy can be considered as best choice during
pregnancy. A comparative risk assessment of the existent drugs as well as
taking into account each individual’s medical history is important.
Furthermore, in case of an unplanned pregnancy with inadvertent use of a
teratogenic or otherwise not recommended drug the patient would like to get a
detailed and quantitative evaluation of risks. This work contributes to the
risk specification and quantification of selected immunomodulatory drugs in
pregnancy. It analyses the impact of low-dose methotrexate (MTX),
mycophenolate, TNF-α inhibitors, interferon-β and glatiramer acetate on
pregnancy outcomes by conducting prospective observational studies. Data of
both exposed and non-exposed cohorts were obtained from the data pool of the
Embryotox institute; according to the criteria of the respective study
protocol. In case of multicenter studies, the same method of ascertainment
applied for each center. Outcomes of pregnancies fathered by men on low-dose
MTX around conception (n=113) were compared with a control group of non-
exposed fathers (n=412). We neither found an increased risk of spontaneous
abortion nor an increased malformation rate or a higher number of de novo
chromosomal disorders. The result of our study does not support the necessity
of a 3-month MTX-free interval until conception. Furthermore, maternal pre-
conception low-dose MTX therapy (n=136) was not associated with increased
prenatal risks. However, if low-dose MTX was incidentally used in the 1st
trimester (n=188), the probability of spontaneous abortion was 42.5% which is
significantly higher than the risk in the healthy comparison cohort (17.3%).
The rate of major malformations in the exposed group was 6.6%, a significant
increase in comparison with the healthy group (2.9%), whereas significance was
not reached in comparison with the diseased control group (3.6%). No infant or
fetus exhibited anomalies consistent with the characteristic MTX embryopathy.
In case of inadvertent MTX exposure during early pregnancy, treatment should
be stopped immediately and a level II prenatal ultrasound should be offered.
The same approach should be followed in case of inadvertent mycophenolate
treatment. A prospective multicenter case series with 57 exposed pregnancies
evaluated a major malformation rate of 26%. About half of these had defects
consistent with a mycophenolate embryopathy phenotype. Spontaneous abortions
occurred more frequently than usual, with a cumulative incidence of 45%. A
prospective multicenter cohort study on TNF-α inhibitors during at least the
first trimester was conducted. In total, 495 exposed pregnancies were compared
with 1532 non-exposed healthy pregnancies. It was expected…
Advisors/Committee Members: [email protected] (contact), w (gender), Prof. Dr. med. Petra A. Thürmann (firstReferee), Prof. Dr. med. Walter E. Haefeli (furtherReferee).
Subjects/Keywords: immunmodulatory drugs; pregnancy; birth defect; spontaneous abortion; low-dose methotrexate; TNF-α inhibitor; mycophenolate;
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APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Weber-Schöndorfer, C. (2016). Specification of the risk profile of selected immunomodulatory drugs during
pregnancy. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-6399
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Weber-Schöndorfer, Corinna. “Specification of the risk profile of selected immunomodulatory drugs during
pregnancy.” 2016. Thesis, Freie Universität Berlin. Accessed January 16, 2021.
http://dx.doi.org/10.17169/refubium-6399.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Weber-Schöndorfer, Corinna. “Specification of the risk profile of selected immunomodulatory drugs during
pregnancy.” 2016. Web. 16 Jan 2021.
Vancouver:
Weber-Schöndorfer C. Specification of the risk profile of selected immunomodulatory drugs during
pregnancy. [Internet] [Thesis]. Freie Universität Berlin; 2016. [cited 2021 Jan 16].
Available from: http://dx.doi.org/10.17169/refubium-6399.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Weber-Schöndorfer C. Specification of the risk profile of selected immunomodulatory drugs during
pregnancy. [Thesis]. Freie Universität Berlin; 2016. Available from: http://dx.doi.org/10.17169/refubium-6399
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
13.
Sterling, John W. (John Wilson).
Mother-Infant Interaction with Facially Deformed Infants.
Degree: 1986, North Texas State University
URL: https://digital.library.unt.edu/ark:/67531/metadc331799/
► This study investigated the interactions of facially deformed infants (FD) with their mothers compared to a facially nondeformed control group (FND). All mother-infant dyads were…
(more)
▼ This study investigated the interactions of facially deformed infants (FD) with their mothers compared to a facially nondeformed control group (FND). All mother-infant dyads were videotaped for 10 minutes during a free play period. Mothers were instructed to spend time with their baby as they normally would. The videotaped interactions of 14 FD dyads and 14 FND dyads were rated by five raters for quality of interactions, amount of vocalization, touch, and face-to-face gaze. The infants were rated on their level of attractiveness from polaroid pictures and videotapes. Mothers also completed a questionnaire which assessed their infants' temperament. Three of the studies' four hypotheses were confirmed. First, the more attractive an infant was, the better his/her interactions with the mother were judged to be. Second, FD infant dyads were rated as significantly poorer in quality of interaction than FND dyads, although FD* dyads did not spend significantly less time vocalizing, touching, or in face-to-face gaze as predicted. A significantly higher percentage of FD infants were judged as having difficult temperament relative to FND infants. Finally, as predicted it was found that infants with difficult temperaments were more likely to exhibit poorer quality interactions than infants with less difficult temperaments. These results have important implications for providing anticipatory guidance to caregivers of FD infants. Without intervention, FD infants appear at risk for subsequent developmental problems stemming from disrupted early mother-infant interactions. Future research should focus on these interactions soon after the infant's
birth, attempt to determine if FD infants' emotions can be reliably understood from their facial expressions (as has been found in normal infants) and extend the current research paradigm to include fathers of FD infants.
Advisors/Committee Members: Doster, Joseph A., 1943-, Burke, Angela J., Toledo, Jose Raphael, Peek, Leon A..
Subjects/Keywords: structural birth defect; facial deformitites; mother-child relationship; Face – Abnormalities – Psychological aspects.; Mother and child.; Infant psychology.
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14.
Hoeltzenbein, Maria.
Arzneimitteltherapie chronischer Erkrankungen im 1.Trimenon unter besonderer Berücksichtigung des Spontanabort- und Fehlbildungsrisikos.
Degree: 2018, Freie Universität Berlin
URL: http://dx.doi.org/10.17169/refubium-1349
► Die Zahl der Frauen mit Kinderwunsch bei chronischen Erkrankungen hat in den letzten Jahren zugenommen. Damit steigt der Informationsbedarf bezüglich einer sicheren und wirksamen Arzneimitteltherapie…
(more)
▼ Die Zahl der Frauen mit Kinderwunsch bei chronischen Erkrankungen hat in den letzten Jahren zugenommen. Damit steigt der Informationsbedarf bezüglich einer sicheren und wirksamen Arzneimitteltherapie während einer Schwangerschaft. Leider sind die Erfahrungen zu vielen Arzneimitteln in der Schwangerschaft noch immer begrenzt, so dass teilweise notwendige Therapien aufgrund einer falschen Risikoeinschätzung unterbleiben. Bei ungeplanten Schwangerschaften kann eine Exposition mit einem nicht für die Schwangerschaft geeigneten Arzneimittel resultieren. Dies ist insbesondere vor dem Hintergrund, dass etwa 40% aller Schwangerschaften ungeplant entstehen, bedeutsam.
Ein erhöhtes Risiko für Spontanaborte oder Fehlbildungen nach Methyldopa- oder AT1-Antagonisten-Exposition im 1. Trimenon konnte nicht nachgewiesen werden. Allerdings wurden AT1-Antagonisten häufig relativ früh in der Schwangerschaft abgesetzt, so dass ein höheres Risiko bei längerer Therapie im 1. Trimenon letztendlich nicht ausgeschlossen werden kann. Das in unserer Studie aufgefallene erhöhte Risiko für Frühgeburtlichkeit nach einer Monotherapie der chronischen Hypertonie mit Methyldopa im Vergleich zu Metoprolol sollte in weiteren Studien überprüft werden.
Die neuen bzw. direkten oralen Antikoagulantien werden außerhalb der Schwangerschaft zunehmend zur Therapie von thromboembolischen Erkrankungen oder bei Vorhofflimmern eingesetzt. Es ist daher zu erwarten, dass auch vermehrt eine Exposition mit direkten oralen Antikoagulantien in der Frühschwangerschaft erfolgt und sich die Frage nach dem Risiko bzw. der Option einer Fortführung der Therapie in der Schwangerschaft stellt. In unserer Auswertung Rivaroxaban exponierter Schwangerschaften fanden wir keine Hinweise auf ein deutlich erhöhtes Fehlbildungs- oder Spontanabortrisiko. Die Ergebnisse unserer Studie können helfen, mit Rivaroxaban behandelten Frauen, die aufgrund der unklaren Datenlage zunächst verunsichert sind und einen Schwangerschaftsabbruch erwägen, eine bessere Entscheidungsgrundlage zu geben. Aufgrund der derzeit noch unzureichenden Erfahrungen und des auch bei diesem Arzneimittel erwiesenen plazentaren Übergangs sollten niedermolekulare Heparine dem Rivaroxaban gegenüber bevorzugt werden.
In einer prospektiven multizentrischen Studie mit Beteiligung verschiedener europäischer teratologischer Beratungszentren konnten wir für Mycophenolat das bisher nur aufgrund von Fallberichten und kleinen Fallserien geäußerte Risiko für Fehlbildungen bestätigen. Auch die Spontanabortrate war deutlich erhöht. Der Phänotyp der Mycophenolat-Embryopathie konnte weiter präzisiert werden, jedoch war die Einordnung von isolierten Fehlbildungen nach Mycophenolat-Exposition schwierig. Ein ähnliches Fehlbildungsmuster wie bei der Mycophenolat-Embryopathie wurde auch in einem Fallbericht nach einer mütterlichen Allopurinol-Exposition beschrieben. Die darauffolgende Auswertung der im PVZ Embryotox erfassten Schwangerschaften ergab weitere Hinweise auf ein teratogenes Risiko durch Allopurinol. Allerdings scheint das…
Advisors/Committee Members: female (gender), Mörike, Klaus (firstReferee), Wieacker, Peter (furtherReferee).
Subjects/Keywords: pregnancy; medication; birth defect; spontaneous abortion; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
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MLA ·
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APA (6th Edition):
Hoeltzenbein, M. (2018). Arzneimitteltherapie chronischer Erkrankungen im 1.Trimenon unter besonderer Berücksichtigung des Spontanabort- und Fehlbildungsrisikos. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-1349
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Hoeltzenbein, Maria. “Arzneimitteltherapie chronischer Erkrankungen im 1.Trimenon unter besonderer Berücksichtigung des Spontanabort- und Fehlbildungsrisikos.” 2018. Thesis, Freie Universität Berlin. Accessed January 16, 2021.
http://dx.doi.org/10.17169/refubium-1349.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Hoeltzenbein, Maria. “Arzneimitteltherapie chronischer Erkrankungen im 1.Trimenon unter besonderer Berücksichtigung des Spontanabort- und Fehlbildungsrisikos.” 2018. Web. 16 Jan 2021.
Vancouver:
Hoeltzenbein M. Arzneimitteltherapie chronischer Erkrankungen im 1.Trimenon unter besonderer Berücksichtigung des Spontanabort- und Fehlbildungsrisikos. [Internet] [Thesis]. Freie Universität Berlin; 2018. [cited 2021 Jan 16].
Available from: http://dx.doi.org/10.17169/refubium-1349.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Hoeltzenbein M. Arzneimitteltherapie chronischer Erkrankungen im 1.Trimenon unter besonderer Berücksichtigung des Spontanabort- und Fehlbildungsrisikos. [Thesis]. Freie Universität Berlin; 2018. Available from: http://dx.doi.org/10.17169/refubium-1349
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Melbourne
15.
Menezes, Melody Ann.
Life on the front line: exploring personal and professional impacts on healthcare professionals working with fetal anomaly.
Degree: 2010, University of Melbourne
URL: http://hdl.handle.net/11343/35970
► It has been just over 2 decades since the establishment of the Human Genome project, which has served to significantly enhance the capabilities of prenatal…
(more)
▼ It has been just over 2 decades since the establishment of the Human Genome project, which has served to significantly enhance the capabilities of prenatal screening and testing. Pregnant women are offered a number of antenatal screening and diagnostic tests which give them information about their fetus, and can identify potential anomalies before it is born. This has consequently led to increases in the number of fetal anomalies that are identified in the prenatal period, and each year in Victoria, Australia 4% of pregnancies will be affected with a fetal anomaly (Riley & Halliday, 2008). Given these rapid advances, it is important to explore the interface between prenatal testing technology and society. While there has been some research on women’s experiences of a diagnosis of a fetal anomaly in pregnancy, it is also important to explore the experiences of healthcare professionals working in this setting. Healthcare professionals are at the forefront of new technologies and play an integral role in administering prenatal tests and supporting patients through the process of diagnosis and thereafter. However, to date there has been very little research on how healthcare professionals experience being involved in this process and the potential impact this may have on them and their practice.
This study sought to address this gap in the literature and aimed to explore whether working with fetal anomaly has an impact on healthcare professionals, and identify any supports used and/or needed. Due to the limited amount of research in this area, a qualitative approach was utilised to provide an in-depth exploration of a range of views and experiences.
Interviews were conducted with 40 healthcare professionals working in fetal medicine settings in Melbourne, Victoria: 11 medical practitioners and 29 allied health professionals. Qualitative analysis identified a range of challenging situations and demonstrated that working with fetal anomaly had a substantial personal and professional impact on participants. Caring for patients in crisis, the urgency of the setting due to patients’ advancing pregnancy, and the difficulties with communicating ‘bad’ news were discussed as intrinsic factors contributing to the difficulty of the clinical environment. Participants also discussed, at length, the personal emotional impact of their work and believed this was instrumental in feeling burdened by caring for patients at this time of grief. Many reported that working with fetal anomaly had repercussions for their daily lives, particularly when they were pregnant themselves. The provision of termination of pregnancy services was described as an implicit aspect of the fetal medicine setting, and participants spoke about many challenges that were encountered due to their involvement with this process. Despite the difficult nature of working in this clinical environment, participants described their job as fulfilling. However, they also perceived…
Subjects/Keywords: prenatal; fetal anomaly; fetal medicine; pregnancy; countertransference; qualitative; pregnant health professional; fetal abnormality; birth defect; allied health; health professional; burnout; compassion fatigue; breaking bad news
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APA ·
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CSE |
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APA (6th Edition):
Menezes, M. A. (2010). Life on the front line: exploring personal and professional impacts on healthcare professionals working with fetal anomaly. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/35970
Chicago Manual of Style (16th Edition):
Menezes, Melody Ann. “Life on the front line: exploring personal and professional impacts on healthcare professionals working with fetal anomaly.” 2010. Doctoral Dissertation, University of Melbourne. Accessed January 16, 2021.
http://hdl.handle.net/11343/35970.
MLA Handbook (7th Edition):
Menezes, Melody Ann. “Life on the front line: exploring personal and professional impacts on healthcare professionals working with fetal anomaly.” 2010. Web. 16 Jan 2021.
Vancouver:
Menezes MA. Life on the front line: exploring personal and professional impacts on healthcare professionals working with fetal anomaly. [Internet] [Doctoral dissertation]. University of Melbourne; 2010. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/11343/35970.
Council of Science Editors:
Menezes MA. Life on the front line: exploring personal and professional impacts on healthcare professionals working with fetal anomaly. [Doctoral Dissertation]. University of Melbourne; 2010. Available from: http://hdl.handle.net/11343/35970
16.
Skiles, William Mark.
Environmentally Induced Epimutations, Their Persistence, and Potential Causality in the Development of Disease in the Offspring of Exposed Individuals.
Degree: PhD, Biomedical Sciences, 2017, Texas A&M University
URL: http://hdl.handle.net/1969.1/173200
► In recent years, there has been increased interest into better understanding how environmental In recent years, there has been increased interest into better understanding how…
(more)
▼ In recent years, there has been increased interest into better understanding how environmental In recent years, there has been increased interest into better understanding how
environmental exposures influence the long-term health of an organism. Chemical
pollutants, dietary deficiencies, embryonic stress and multiple other external factors have
all demonstrated long-lasting effects upon development, metabolism, and health even after
transient exposures. The mechanisms by which these exposures can impact development
far beyond the period of exposure remain largely unknown. To gain better insight into the
developmental origins of both
birth defects and disease, we must better understand how
environmental exposures alter development.
In this work, we will examine the capacity of the environment to impact chromatin
states, and then determine whether these changes are heritable; and are thus potentially
causal in the development of disease. This is an important question due to the recent
recognition that aberrant chromatin states can lead to pathological patterns of gene
expression, a circumstance commonly referred to as “epimutations”. Dysregulation of
gene expression patterns during development have been shown to cause a multitude of
irregular phenotypes in offspring and lifelong disorders in mature organisms. This altered
chromatin state, coined an epimutation by Dr. Emma Whitelaw, is important due to the
mutation not being in the genetic code itself, but in the way DNA regulatory regions are
packaged within the chromatin template, and thus accessed by the protein factors directing
gene transcription. The body of work presented here will examine the ability of common
environmental exposures to modulate chromatin structure. We will examine these changes over time in an effort to better understand the inheritance of epigenetic change. Secondly,
we will measure whether environmentally induced alterations in chromatin structure
within the germline persist, and are heritable. These questions are all relevant to better
understanding the developmental origins of disease.
Advisors/Committee Members: Golding, Michael C (advisor), Long, Charles R (advisor), Seabury, Christopher M (committee member), Johnson, Natalie M (committee member).
Subjects/Keywords: oxidative stress; assisted reproductive technologies; genomic imprinting; histone demethylase; TET; DNMT; DNA methylation; epigenetics; developmental programming; DOHAD; birth defect; epigenetics; preconception; sperm
…incidence of birth
defects. Chemical pollutants, dietary deficiencies, embryonic stress and… …insight into the developmental origins of both birth
defects and disease, we must better… …birth and had major developmental defects such as growth
impairment and rostral neural tube… …before birth. In the female embryo (red line), primary oocytes enter meiosis and… …arrest in prophase-I (diplotene stage); DNA methylation is established after birth…
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APA ·
Chicago ·
MLA ·
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CSE |
Export
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Manager
APA (6th Edition):
Skiles, W. M. (2017). Environmentally Induced Epimutations, Their Persistence, and Potential Causality in the Development of Disease in the Offspring of Exposed Individuals. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/173200
Chicago Manual of Style (16th Edition):
Skiles, William Mark. “Environmentally Induced Epimutations, Their Persistence, and Potential Causality in the Development of Disease in the Offspring of Exposed Individuals.” 2017. Doctoral Dissertation, Texas A&M University. Accessed January 16, 2021.
http://hdl.handle.net/1969.1/173200.
MLA Handbook (7th Edition):
Skiles, William Mark. “Environmentally Induced Epimutations, Their Persistence, and Potential Causality in the Development of Disease in the Offspring of Exposed Individuals.” 2017. Web. 16 Jan 2021.
Vancouver:
Skiles WM. Environmentally Induced Epimutations, Their Persistence, and Potential Causality in the Development of Disease in the Offspring of Exposed Individuals. [Internet] [Doctoral dissertation]. Texas A&M University; 2017. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/1969.1/173200.
Council of Science Editors:
Skiles WM. Environmentally Induced Epimutations, Their Persistence, and Potential Causality in the Development of Disease in the Offspring of Exposed Individuals. [Doctoral Dissertation]. Texas A&M University; 2017. Available from: http://hdl.handle.net/1969.1/173200
17.
Nahm, Sang-Myong.
Paternal Exposure to Ionizing Radiation in Ontario Uranium Miners and Risk of Congenital Anomaly in Offspring: A Record Linkage Case-control Study.
Degree: 2012, University of Toronto
URL: http://hdl.handle.net/1807/32779
► Objective: To determine if paternal preconception exposure to ionizing radiation through uranium mining increases the risk of congenital anomaly (CA) in offspring. Methods: A population-based…
(more)
▼ Objective: To determine if paternal preconception exposure to ionizing radiation through uranium mining increases the risk of congenital anomaly (CA) in offspring.
Methods: A population-based matched case-control study was conducted. Cases were infants with CAs recorded in the Canadian Congenital Anomalies Surveillance System and born alive in Ontario 1979-86 (ICD-9 codes 740-759); controls were liveborn infants without CAs identified from Ontario birth certificates and individually matched to cases (case-control file {CCF}). Exposed fathers were identified through the linkage of the CCF to the Mining Master File or the National Dose Registry file, which include those who worked in Ontario uranium mines 1952-1986. For men who linked with a case or control child, radon, gamma and total gonadal doses were estimated for three preconception periods: entire, 3-months and 6-months. Odds ratios were estimated using conditional logistic regression.
Results: Linkage of 28,991 uranium miners and 40,482 case-control pairs of fathers and offspring in the CCF identified 431 discordant pairs. There was no evidence of increased risk of a child having a CA if the father was ever a uranium miner before conception of the child (OR=0.89, 95% CI=0.74–1.08). Since gamma radiation (especially during the 6-month preconception period) is more biologically relevant to gonads than radon, further analyses were performed on 117 discordant pairs where data on gamma exposures were available. When ever/never miner, exposed to gamma (yes/no), and gamma dose-response variables were all in the model, there was no ever/never miner effect (OR=1.20, 95% CI=0.85–1.69, p-value=0.30), an inverse association for exposure to gamma (OR=0.42, 95% CI=0.25–0.71, p-value=0.001), but most importantly, there was no statistically significant dose-response relationship between gamma dose during the 6-month preconception period and all CAs (OR=1.15 per loge {mSv+0.01}, 95% CI=0.83–1.59, p-value=0.40). Similarly, no dose-response relationship was observed for exposure to gamma radiation in the 3-month preconception period, or for radon or total gonadal radiation in the 3- or 6-month preconception periods.
Conclusion: There was no increased risk of a CA among liveborn children of Ontario uranium miners who were exposed to radon, gamma or total radiation during the 3- or 6-month periods before conception.
PhD
Advisors/Committee Members: Marrett, Loraine, Dalla Lana School of Public Health.
Subjects/Keywords: Ionizing radiation; uranium; uranium miners; radon; gamma ray; radiation measurement; radiation effects; occupational exposure; occupational health and safety; environmental exposure; paternal exposure; paternal exposure delayed effects; male reproduction; transgenerational effect; pregnancy outcome; congenital anomaly; birth defect; infant; offspring; live birth; record linkage; case control study; 0766; 0354; 0573
…birth
outcomes… …child birth years
1982-1986)… …study file (child birth years 1982-1986)… …anomaly
CBDMP
California Birth Defects Monitoring Program
CCASS
Canadian Congenital… …Council (of The National Academies)
N.S.
not significant
NTD
neural tube defect…
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Nahm, S. (2012). Paternal Exposure to Ionizing Radiation in Ontario Uranium Miners and Risk of Congenital Anomaly in Offspring: A Record Linkage Case-control Study. (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/32779
Chicago Manual of Style (16th Edition):
Nahm, Sang-Myong. “Paternal Exposure to Ionizing Radiation in Ontario Uranium Miners and Risk of Congenital Anomaly in Offspring: A Record Linkage Case-control Study.” 2012. Doctoral Dissertation, University of Toronto. Accessed January 16, 2021.
http://hdl.handle.net/1807/32779.
MLA Handbook (7th Edition):
Nahm, Sang-Myong. “Paternal Exposure to Ionizing Radiation in Ontario Uranium Miners and Risk of Congenital Anomaly in Offspring: A Record Linkage Case-control Study.” 2012. Web. 16 Jan 2021.
Vancouver:
Nahm S. Paternal Exposure to Ionizing Radiation in Ontario Uranium Miners and Risk of Congenital Anomaly in Offspring: A Record Linkage Case-control Study. [Internet] [Doctoral dissertation]. University of Toronto; 2012. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/1807/32779.
Council of Science Editors:
Nahm S. Paternal Exposure to Ionizing Radiation in Ontario Uranium Miners and Risk of Congenital Anomaly in Offspring: A Record Linkage Case-control Study. [Doctoral Dissertation]. University of Toronto; 2012. Available from: http://hdl.handle.net/1807/32779
. 
Open Access Theses and Dissertations
