subject:(biocompatibility)

Wake Forest University

1. Zakhem, Elie. BIOENGINEERING CHITOSAN-BASED TUBULAR NEURO-MUSCULAR GASTROINTESTINAL TISSUE.

Degree: 2016, Wake Forest University

► The gastrointestinal (GI) tract is a hollow muscular tubular organ that extends from the mouth down to the rectum. Different high pressure zones exist along… (more)

Subjects/Keywords: biocompatibility

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APA (6^th Edition):

Zakhem, E. (2016). BIOENGINEERING CHITOSAN-BASED TUBULAR NEURO-MUSCULAR GASTROINTESTINAL TISSUE. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/62643

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Zakhem, Elie. “BIOENGINEERING CHITOSAN-BASED TUBULAR NEURO-MUSCULAR GASTROINTESTINAL TISSUE.” 2016. Thesis, Wake Forest University. Accessed January 17, 2021. http://hdl.handle.net/10339/62643.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Zakhem, Elie. “BIOENGINEERING CHITOSAN-BASED TUBULAR NEURO-MUSCULAR GASTROINTESTINAL TISSUE.” 2016. Web. 17 Jan 2021.

Vancouver:

Zakhem E. BIOENGINEERING CHITOSAN-BASED TUBULAR NEURO-MUSCULAR GASTROINTESTINAL TISSUE. [Internet] [Thesis]. Wake Forest University; 2016. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/10339/62643.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Zakhem E. BIOENGINEERING CHITOSAN-BASED TUBULAR NEURO-MUSCULAR GASTROINTESTINAL TISSUE. [Thesis]. Wake Forest University; 2016. Available from: http://hdl.handle.net/10339/62643

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Waterloo

2. Naahidi, Sheva. Biocompatibility Evaluation of Engineered Amino Acid Pairing Peptides for Drug Delivery.

Degree: 2014, University of Waterloo

URL: http://hdl.handle.net/10012/8226

► To ensure the effective and safe use of nanomaterials for medical applications, the biocompatibility of the materials must be tested with particular relevance to the… (more)

Subjects/Keywords: Biocompatibility; Drug Delivery

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APA (6^th Edition):

Naahidi, S. (2014). Biocompatibility Evaluation of Engineered Amino Acid Pairing Peptides for Drug Delivery. (Thesis). University of Waterloo. Retrieved from http://hdl.handle.net/10012/8226

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Naahidi, Sheva. “Biocompatibility Evaluation of Engineered Amino Acid Pairing Peptides for Drug Delivery.” 2014. Thesis, University of Waterloo. Accessed January 17, 2021. http://hdl.handle.net/10012/8226.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Naahidi, Sheva. “Biocompatibility Evaluation of Engineered Amino Acid Pairing Peptides for Drug Delivery.” 2014. Web. 17 Jan 2021.

Vancouver:

Naahidi S. Biocompatibility Evaluation of Engineered Amino Acid Pairing Peptides for Drug Delivery. [Internet] [Thesis]. University of Waterloo; 2014. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/10012/8226.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Naahidi S. Biocompatibility Evaluation of Engineered Amino Acid Pairing Peptides for Drug Delivery. [Thesis]. University of Waterloo; 2014. Available from: http://hdl.handle.net/10012/8226

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Florida International University

3. Karbasi, Ali. Developing a High Density Pt/Alumina Hermetic Feedthrough.

Degree: PhD, Materials Science and Engineering, 2012, Florida International University

URL: https://digitalcommons.fiu.edu/etd/667 ; 10.25148/etd.FI12072704 ; FI12072704

► Typically, hermetic feedthroughs for implantable devices, such as pacemakers, use a alumina ceramic insulator brazed to a platinum wire pin. This combination of material… (more)

▼ Typically, hermetic feedthroughs for implantable devices, such as pacemakers, use a alumina ceramic insulator brazed to a platinum wire pin. This combination of material has a long history in implantable devices and has been approved by the FDA for implantable hermetic feedthroughs. The growing demand for increased input/output (I/O) hermetic feedthroughs for implantable neural stimulator applications could be addressed by developing a new, cofired platinum/alumina multilayer ceramic technology in a configuration that supports 300 plus I/Os, which is not commercially available. Seven platinum powders with different particle sizes were used to develop different conductive cofire inks to control the densification mismatch between platinum and alumina. Firing profile (ramp rate, burn- out and holding times) and firing atmosphere and concentrations (hydrogen (wet/dry), air, neutral, vacuum) were also optimized. Platinum and alumina exhibit the alloy formation reaction in a reduced atmosphere. Formation of any compound can increase the bonding of the metal/ceramic interface, resulting in enhanced hermeticity. The feedthrough fabricated in a reduced atmosphere demonstrated significantly superior performance than that of other atmospheres. A composite structure of tungsten/platinum ratios graded thru the via structure (pure W, 50/50 W/Pt, 80/20 Pt/W and pure Pt) exhibited the best performance in comparison to the performance of other materials used for ink metallization. Studies on the high temperature reaction of platinum and alumina, previously unreported, showed that, at low temperatures in reduced atmosphere, Pt₃Al or Pt₈Al₂₁ with a tetragonal structure would be formed. Cubic Pt₃Al is formed upon heating the sample to temperatures above 1350 °C. This cubic structure is the equilibrium state of Pt-Al alloy at high temperatures. The alumina dissolves into the platinum ink and is redeposited as a surface coating. This was observed on both cofired samples and pure platinum thin films coated on a 99.6 Wt% alumina and fired at 1550 °C. Different mechanisms are proposed to describe this behavior based on the size of the platinum particle. Advisors/Committee Members: W. Kinzy Jones, Wenzhi Li, Jiuhua Chen, Arvind Agarwal.

Subjects/Keywords: Feedthrough; Biocompatibility; Hermeticity

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APA (6^th Edition):

Karbasi, A. (2012). Developing a High Density Pt/Alumina Hermetic Feedthrough. (Doctoral Dissertation). Florida International University. Retrieved from https://digitalcommons.fiu.edu/etd/667 ; 10.25148/etd.FI12072704 ; FI12072704

Chicago Manual of Style (16^th Edition):

Karbasi, Ali. “Developing a High Density Pt/Alumina Hermetic Feedthrough.” 2012. Doctoral Dissertation, Florida International University. Accessed January 17, 2021. https://digitalcommons.fiu.edu/etd/667 ; 10.25148/etd.FI12072704 ; FI12072704.

MLA Handbook (7^th Edition):

Karbasi, Ali. “Developing a High Density Pt/Alumina Hermetic Feedthrough.” 2012. Web. 17 Jan 2021.

Vancouver:

Karbasi A. Developing a High Density Pt/Alumina Hermetic Feedthrough. [Internet] [Doctoral dissertation]. Florida International University; 2012. [cited 2021 Jan 17]. Available from: https://digitalcommons.fiu.edu/etd/667 ; 10.25148/etd.FI12072704 ; FI12072704.

Council of Science Editors:

Karbasi A. Developing a High Density Pt/Alumina Hermetic Feedthrough. [Doctoral Dissertation]. Florida International University; 2012. Available from: https://digitalcommons.fiu.edu/etd/667 ; 10.25148/etd.FI12072704 ; FI12072704

University of Manchester

4. Shellard, Philippa. Functionalised graphene for biomedical applications.

Degree: 2017, University of Manchester

URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:309614

► There has been increasing interest in the use of pristine graphene in biomedical applications, but its use is limited by its hydrophobicity and lack of… (more)

▼ There has been increasing interest in the use of pristine graphene in biomedical applications, but its use is limited by its hydrophobicity and lack of functional groups by which to tether molecules, meaning that biological applications of pristine graphene rely on non-specific adsorption of molecules. Furthermore, pristine graphene cannot be used in-vivo due to its poor aqueous dispersibility. Functional groups are introduced to graphene to overcome these problems, but many functionalisation methods cause significant disruption to the extended Ï€-system of graphene, from which its favourable properties arise. The aim of this thesis was to address the limitations of using pristine graphene outlined above. The solution proposed was the edge-specific sulfonation and thiol functionalisation of pristine graphene, based upon electrophilic aromatic substitution. The nature of these reactions means that they should cause minimal defect formation, occurring selectively at existing defects and edges of the graphene sheet. The sulfonation of graphene was selected to increase the aqueous dispersibility of pristine graphene, while the thiol functionalisation would provide a means by which to tether molecules covalently to the graphene sheet. The functionalisations were confirmed using a range of analyses, which indicated a low level of new defect formation, as well as demonstrating both the presence of the target functional groups and the change in aqueous dispersibility of the graphene sheets. Furthermore, the functionalisation was shown to be edge-specific by attaching a fluorescent protein to thiol functional groups on the edges. G-SO3 was incorporated into a polymer layer-by-layer (LbL) construct, for use in wound healing applications, together with analogous constructs containing graphene oxide (GO) and sulfonate-functionalised GO (GO-SO3). The constructs were characterised, to assess the effect of different functionalisations on the coverage of graphene. Analysis confirmed the presence of G-SO3, GO and GO-SO3 in the constructs, but indicated a lower graphene coverage for the G-SO3 construct, thought to be a result of the lower number of functional groups in this material. The biocompatibility of G-SO3, GO and GO-SO3 LbL constructs was tested on 3T3 Swiss Albino fibroblast cells and human mesenchymal stem cells. In addition, the differentiation of stem cells on these graphene-containing surfaces was monitored and compared to published work on graphene-family nanomaterials. The biocompatibility studies revealed that cell adhesion and proliferation were dictated by extracellular matrix (ECM) protein adsorption on the LbL constructs. The substrates able to bind higher amounts of ECM protein were found to show greater cell adhesion and proliferation, with ECM protein binding correlated to the roughness and surface chemistry of the constructs. Future applications would be to introduce alternative functional groups to graphene, using the principles outlined in this thesis. In addition, there is potential for the attachment of a… Advisors/Committee Members: HAIGH, SARAH S, BLANFORD, CHRISTOPHER CF, Flitsch, Sabine, Haigh, Sarah, Blanford, Christopher.

Subjects/Keywords: graphene; toxicity; biocompatibility

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APA (6^th Edition):

Shellard, P. (2017). Functionalised graphene for biomedical applications. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:309614

Chicago Manual of Style (16^th Edition):

Shellard, Philippa. “Functionalised graphene for biomedical applications.” 2017. Doctoral Dissertation, University of Manchester. Accessed January 17, 2021. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:309614.

MLA Handbook (7^th Edition):

Shellard, Philippa. “Functionalised graphene for biomedical applications.” 2017. Web. 17 Jan 2021.

Vancouver:

Shellard P. Functionalised graphene for biomedical applications. [Internet] [Doctoral dissertation]. University of Manchester; 2017. [cited 2021 Jan 17]. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:309614.

Council of Science Editors:

Shellard P. Functionalised graphene for biomedical applications. [Doctoral Dissertation]. University of Manchester; 2017. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:309614

University of Otago

5. Aziz, Manal. Biological Properties of a Chitosan/Dextran- Based Surgical Hydrogel .

Degree: 2013, University of Otago

URL: http://hdl.handle.net/10523/4340

► Postoperative complications are the main cause of morbidity and mortality following surgery and therefore have a significant impact on healthcare resources. Recently, polymers have gained… (more)

▼ Postoperative complications are the main cause of morbidity and mortality following surgery and therefore have a significant impact on healthcare resources. Recently, polymers have gained considerable attention for use in barrier based systems to prevent postoperative adhesions. A new hydrogel, which is based on the interactions of amine groups of succinyl chitosan (SC) and the aldehyde groups of dextran aldehyde (DA), was developed in our laboratory and has shown promising results in endoscopic sinus surgery. The main objective of this thesis is to describe the biological interactions of the CD hydrogel and its ability to act as an aid in endoscopic sinus surgery. Chitosan was succinylated by succinic anhydride and hydrolysed in strong base at 60°C to obtain the desirable SC with effective cross-linking and solubility. Dextran was oxidised by sodium periodate to prepare DA with 168% oxidation. General properties of the polymeric compounds were characterised by microanalysis and NMR spectroscopy. The CD hydrogel was studied in two distinct phases. The first stage consisted of examining the antimicrobial activity of CD hydrogel and its components in vitro by broth microdilution procedure against a range of pathogenic nosocomial microorganisms. Minimum inhibitory concentrations (MIC), minimum bactericidal concentrations (MBC) and minimum fungicidal concentrations (MFC) values were determined on various Gram-negative, Gram-positive, and one fungal species that frequently causes postoperative infections. The CD hydrogel and DA alone were found to inhibit and kill all investigated Gram-positive species in lower concentration as compared to Gram-negative bacteria. None of the tested microorganisms were susceptible to SC alone. In addition, time-dependent killing efficacy of DA for two bacterial species was tested. The antimicrobial results led to an investigation into the mode of action, specificity and effectiveness of the CD hydrogel. Scanning and transmission electron microscopy showed a change in the bacterial membrane after being incubated with CD hydrogel and DA below the MBC. In addition, motility and chemotaxis test results showed that DA at 32,000 mg L⁻¹ concentration had more inhibitory action than the concentration of 16,000 mg L⁻¹ on the bacterial flagella and movement. The second stage consisted of investigating the biocompatibility of CD hydrogel and its components in vitro, aiming to be used as a surgical barrier on humans in endoscopic sinus surgery. The cytotoxicity of CD hydrogel and its components was evaluated by the xCELLigence system, crystal violet, and light microscopy methods, on human cell lines. SC was revealed to be non-toxic, while DA was the toxic and the active component of the CD hydrogel. The results of Ames testing with S. Typhimurium strains in the presence and absence of S9 fraction indicated that CD hydrogel and DA were non-mutagenic. To reduce possible problems with regulatory approval regarding the cytotoxity, the DA concentration was reduced to 3% instead of 5% in the early… Advisors/Committee Members: Moratti, Stephen (advisor).

Subjects/Keywords: Chitosan; Hydrogel; Surgery; Biocompatibility; Antimicrobial

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APA (6^th Edition):

Aziz, M. (2013). Biological Properties of a Chitosan/Dextran- Based Surgical Hydrogel . (Doctoral Dissertation). University of Otago. Retrieved from http://hdl.handle.net/10523/4340

Chicago Manual of Style (16^th Edition):

Aziz, Manal. “Biological Properties of a Chitosan/Dextran- Based Surgical Hydrogel .” 2013. Doctoral Dissertation, University of Otago. Accessed January 17, 2021. http://hdl.handle.net/10523/4340.

MLA Handbook (7^th Edition):

Aziz, Manal. “Biological Properties of a Chitosan/Dextran- Based Surgical Hydrogel .” 2013. Web. 17 Jan 2021.

Vancouver:

Aziz M. Biological Properties of a Chitosan/Dextran- Based Surgical Hydrogel . [Internet] [Doctoral dissertation]. University of Otago; 2013. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/10523/4340.

Council of Science Editors:

Aziz M. Biological Properties of a Chitosan/Dextran- Based Surgical Hydrogel . [Doctoral Dissertation]. University of Otago; 2013. Available from: http://hdl.handle.net/10523/4340

University of Utah

6. Ramachandran, Sivakumar. Design and characterization of peptide-based biomaterials;.

Degree: PhD, Pharmaceutics & Pharmaceutical Chemistry;, 2007, University of Utah

URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1401/rec/289

► The main objective of this dissertation is to lay out the design principles involved in assembling stimuli-sensitive, peptide-based biomaterials that has potential for various biomedical… (more)

▼ The main objective of this dissertation is to lay out the design principles involved in assembling stimuli-sensitive, peptide-based biomaterials that has potential for various biomedical applications like tissue engineering and drug delivery. Supramolecular systems, which enable one to assemble novel materials from molecular level, have fascinated researchers in many disciplines. Inspired by such systems, a set of mutually complementary, self-repulsive oligopeptide modules (with alternating polar-apolar amino acid sequence) were designed to gain better control and wide range of tunability over the assembling process. These peptide modules (at 0.25 wt% in aqueous buffer) assembled into a hydrogel network with change in pH/ionic strength (self-assembly) and upon mixing the two mutually-complementary peptide modules (co-assembly). Mixing induced hydrogels are particularly attractive as they can be easily assembled by simple mixing of peptide solutions prior to application. Another advantage of mixing-induced gelation is that it preserves the pH and ionic strength of the original peptide solutions. Circular dichroism spectroscopy of individual decapeptide solutions revealed their random coil conformation. Transmission electron microscopy images showed the nanofibrillar network structure of the hydrogel. Dynamic rheological characterization revealed its high elasticity and shear-thinning nature. Furthermore, the co-assembled hydrogel was capable of rapid recoveries from repeated shear-induced breakdowns, a property desirable for designing injectable biomaterials. A systematic variation of the neutral amino acids in the sequence revealed some of the design principles for this class of biomaterials. First, viscoelastic properties of the hydrogels can be tuned through adjusting the hydrophobicity of the neutral amino acids. Second, the ?-sheet propensity of the neutral amino acid residue in the peptides is critical for hydrogelation. The compatibility of these hydrogels with entrapped biomolecules (molecular biocompatibility) was confirmed using high-resolution, 1

Subjects/Keywords: Biomedical Materials; Biocompatibility; Theraputic Use

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APA (6^th Edition):

Ramachandran, S. (2007). Design and characterization of peptide-based biomaterials;. (Doctoral Dissertation). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1401/rec/289

Chicago Manual of Style (16^th Edition):

Ramachandran, Sivakumar. “Design and characterization of peptide-based biomaterials;.” 2007. Doctoral Dissertation, University of Utah. Accessed January 17, 2021. http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1401/rec/289.

MLA Handbook (7^th Edition):

Ramachandran, Sivakumar. “Design and characterization of peptide-based biomaterials;.” 2007. Web. 17 Jan 2021.

Vancouver:

Ramachandran S. Design and characterization of peptide-based biomaterials;. [Internet] [Doctoral dissertation]. University of Utah; 2007. [cited 2021 Jan 17]. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1401/rec/289.

Council of Science Editors:

Ramachandran S. Design and characterization of peptide-based biomaterials;. [Doctoral Dissertation]. University of Utah; 2007. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd1/id/1401/rec/289

7. Yu, Miao. Microstructure, Corrosion Behavior, Mechanical Property and Biocompatibility of Compression-molded Zinc-nanodiamond Composites as a Bio-implant Material.

Degree: 2014, Drexel University

URL: http://hdl.handle.net/1860/4444

►

Biodegradable metals have been widely studied in recent years as potential biomedical implant materials. These bio-implants are expected to provide mechanical support during healing and… (more)

▼

Biodegradable metals have been widely studied in recent years as potential biomedical implant materials. These bio-implants are expected to provide mechanical support during healing and then degrade thereafter causing minimum toxicity to surrounding cells and tissues. But current biodegradable magnesium alloys demonstrate major drawbacks, including fast degradation rates and relatively complicated manufacturing conditions. In this dissertation, a novel material, Zinc-nanodiamond (Zn-ND) composite, was proposed and studied because of its desirable corrosion and biocompatible properties. The microstructure, corrosion behavior, mechanical properties and biocompatibility of Zn composites were investigated and powder metallurgy manufacturing processes were used to manufacture the composites.Grain size increased with higher sintering temperature and longer sintering time. Corrosion resistance was improved 61.0%, 65.9% and 70.7% for 1%, 2.5% and 5% ND compared with pure Zn. Compression and hardness tests were performed to determine the mechanical properties. In the compression tests, Zn-1ND showed the highest Young's modulus, 10.95% and 27.32 % more than pure Zn and Zn-5ND. Pure Zn had the highest compressive strength, 11.8% and 29.5% higher than Zn-1ND and Zn-2.5ND. Zn-1ND and Zn-2.5ND are 55.2 % and 68.9 % lower in hardness compared with pure Zn (HV = 27).In the biocompatibility tests, mouse osteoblasts (7F2) were treated with different concentrations of zinc chloride (ZnCl2) media, powders mixed media, and disc extracts. A normal proliferation pattern was observed for cells treated with 0.1 mM ZnCl2 media, while cells treated with powder mixed media presented a decreasing trend in cell proliferation. Compared with control group, there were 20.41%, 59.3%, 36.33% and 46.35% fewer cells for pure Zn, Zn-1ND, Zn-2.5ND and Zn-5ND, respectively. The cell viability was measured by live/dead and Alamar blue assays. Cells remained viable when treated with less than 0.5 mg/mL powder mixed media, or 10% of the sample extracts. This study demonstrates compression-molded zinc with low concentrations of nanodiamond offers a promising combination of strength, low corrosion rate, and biocompatibility, that can be potentially used as a biodegradable implant material.

Ph.D., Mechanical Engineering and Mechanics – Drexel University, 2014

Advisors/Committee Members: Zhou, Jack, College of Engineering.

Subjects/Keywords: Mechanical engineering; Biocompatibility; Materials – Biodegradation

10 more images…

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APA (6^th Edition):

Yu, M. (2014). Microstructure, Corrosion Behavior, Mechanical Property and Biocompatibility of Compression-molded Zinc-nanodiamond Composites as a Bio-implant Material. (Thesis). Drexel University. Retrieved from http://hdl.handle.net/1860/4444

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Yu, Miao. “Microstructure, Corrosion Behavior, Mechanical Property and Biocompatibility of Compression-molded Zinc-nanodiamond Composites as a Bio-implant Material.” 2014. Thesis, Drexel University. Accessed January 17, 2021. http://hdl.handle.net/1860/4444.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Yu, Miao. “Microstructure, Corrosion Behavior, Mechanical Property and Biocompatibility of Compression-molded Zinc-nanodiamond Composites as a Bio-implant Material.” 2014. Web. 17 Jan 2021.

Vancouver:

Yu M. Microstructure, Corrosion Behavior, Mechanical Property and Biocompatibility of Compression-molded Zinc-nanodiamond Composites as a Bio-implant Material. [Internet] [Thesis]. Drexel University; 2014. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/1860/4444.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Yu M. Microstructure, Corrosion Behavior, Mechanical Property and Biocompatibility of Compression-molded Zinc-nanodiamond Composites as a Bio-implant Material. [Thesis]. Drexel University; 2014. Available from: http://hdl.handle.net/1860/4444

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Northeastern University

8. Liu, Luting. Fabrication of nanostructures on implantable biomaterials for biocompatibility enhancement and infection resistance.

Degree: PhD, Department of Chemical Engineering, 2017, Northeastern University

URL: http://hdl.handle.net/2047/D20250935

► An implant or implantable medical device, which is used to replace or restore the function of traumatized or degenerated tissues or organs, or acts as… (more)

▼ An implant or implantable medical device, which is used to replace or restore the function of traumatized or degenerated tissues or organs, or acts as a fraction of or the whole biological structure, has been used in many different parts of the body for various applications (such as orthopedics, cardiovascular stents, or drug delivery systems for medical treatment). The best performance of the vast majority of implants is achieved when the biomaterial used promotes some biological activity (such as bone regeneration) while minimizing undesirable activity (such as infection, one of the most common reasons for the failure of many implants). The surface of the implant, through its interactions with proteins, bacteria and tissue forming cells, plays a critical role in the success or failure of the implant. Therefore, in this study, we sought to employ various nanofabrication techniques for tailoring implant surfaces to minimize bacteria and promote mammalian cell functions without using drugs.; Titanium (Ti) and polyetheretherketone (PEEK) are commonly used biomaterials in orthopedic implants. Further surface modification is needed to support osseointegration while inhibiting bacteria attachment. Herein, temperature controlled atomic layer deposition (ALD) was utilized to provide unique nanostructured TiO2 coatings on commercial Ti. In vitro bacteria experiments revealed that the nano-TiO2 coatings showed promising antimicrobial efficacy towards Gram-positive bacteria (S. aureus), Gram-negative bacteria (E. coli) and antibiotic-resistant bacteria (MRSA). Impressively, cell results indicated that this nano-TiO2 coating stimulated osteoblast (or bone forming cell) adhesion and proliferation while suppressing undesirable fibroblast functions. The same procedure was performed on PEEK and also resulted in enhanced osteoblast functions and produced antimicrobial properties.; In another study, to isolate the effect of surface chemistry on cell and bacteria activities, a simple template-molding method (in which a material with a special structure is used as a template to imprint its structure onto another material) with nanotubular anodized Ti was used to formulate a physical nanostructured pattern on a PDMS (a commonly used polymeric catheter material) surface without changing its surface chemistry. Results showed that increased PDMS surface nanoscale roughness alone inhibited both Gram-negative (E. coli) and Gram-positive (S. aureus) bacteria adhesion and growth without using antibiotics while remaining non-toxic to fibroblasts and endothelial cells. A model was developed for the first time to correlate bacteria responses to nanoscale roughness with initial protein adsorption (specifically, casein protein, which is well known for preventing bacteria attachment). Data also revealed that an increase in nanoscale roughness and greater surface hydrophilicity together contributed to increased protein adsorption, which may decrease the interactions at the bacteria-nanorough surface interface and achieve effective antimicrobial…

Subjects/Keywords: biocompatibility; biomaterials; implants; infection; nanofabrication

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APA (6^th Edition):

Liu, L. (2017). Fabrication of nanostructures on implantable biomaterials for biocompatibility enhancement and infection resistance. (Doctoral Dissertation). Northeastern University. Retrieved from http://hdl.handle.net/2047/D20250935

Chicago Manual of Style (16^th Edition):

Liu, Luting. “Fabrication of nanostructures on implantable biomaterials for biocompatibility enhancement and infection resistance.” 2017. Doctoral Dissertation, Northeastern University. Accessed January 17, 2021. http://hdl.handle.net/2047/D20250935.

MLA Handbook (7^th Edition):

Liu, Luting. “Fabrication of nanostructures on implantable biomaterials for biocompatibility enhancement and infection resistance.” 2017. Web. 17 Jan 2021.

Vancouver:

Liu L. Fabrication of nanostructures on implantable biomaterials for biocompatibility enhancement and infection resistance. [Internet] [Doctoral dissertation]. Northeastern University; 2017. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/2047/D20250935.

Council of Science Editors:

Liu L. Fabrication of nanostructures on implantable biomaterials for biocompatibility enhancement and infection resistance. [Doctoral Dissertation]. Northeastern University; 2017. Available from: http://hdl.handle.net/2047/D20250935

Univerzitet u Beogradu

9. Marković, Evgenija, 1970-. Uticaj strukture ortodontskih žica na biokompatibilnost i percepciju bola tokom početne faze lečenja fiksnim aparatima.

Degree: Farmaceutski fakultet, 2015, Univerzitet u Beogradu

URL: https://fedorabg.bg.ac.rs/fedora/get/o:7662/bdef:Content/get

►

Stomatologija - Ortopedija vilica / Dentistry - Orthodontics

Ciljevi studije su bili: utvrđivanje i poređenje percepcije bola kod pacijenata na početku terapije fiksnim ortodontskim aparatima… (more)

Subjects/Keywords: pain; orthodontics; NiTi archwires; biocompatibility

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APA (6^th Edition):

Marković, Evgenija, 1. (2015). Uticaj strukture ortodontskih žica na biokompatibilnost i percepciju bola tokom početne faze lečenja fiksnim aparatima. (Thesis). Univerzitet u Beogradu. Retrieved from https://fedorabg.bg.ac.rs/fedora/get/o:7662/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Marković, Evgenija, 1970-. “Uticaj strukture ortodontskih žica na biokompatibilnost i percepciju bola tokom početne faze lečenja fiksnim aparatima.” 2015. Thesis, Univerzitet u Beogradu. Accessed January 17, 2021. https://fedorabg.bg.ac.rs/fedora/get/o:7662/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Marković, Evgenija, 1970-. “Uticaj strukture ortodontskih žica na biokompatibilnost i percepciju bola tokom početne faze lečenja fiksnim aparatima.” 2015. Web. 17 Jan 2021.

Vancouver:

Marković, Evgenija 1. Uticaj strukture ortodontskih žica na biokompatibilnost i percepciju bola tokom početne faze lečenja fiksnim aparatima. [Internet] [Thesis]. Univerzitet u Beogradu; 2015. [cited 2021 Jan 17]. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:7662/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Marković, Evgenija 1. Uticaj strukture ortodontskih žica na biokompatibilnost i percepciju bola tokom početne faze lečenja fiksnim aparatima. [Thesis]. Univerzitet u Beogradu; 2015. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:7662/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Limerick

10. Reidy, Colin. Comparative sintering of zirconia and hydroxyapatite-zirconia composites.

Degree: 2010, University of Limerick

URL: http://hdl.handle.net/10344/1644

►

peer-reviewed

Hydroxyapatite [Ca10(PO4)6OH2, HA] is the major constituent of the mineral phase of bone and exhibits desirable properties as a bone graft, such as biocompatibility,… (more)

▼

peer-reviewed

Hydroxyapatite [Ca10(PO4)6OH2, HA] is the major constituent of the mineral phase of bone and exhibits desirable properties as a bone graft, such as biocompatibility, bioactivity, osteoconductivity and direct bonding to bone tissue. However, due to its limited mechanical properties, in particular low fracture toughness (KIC) and tensile strength, HA is limited to non-load bearing applications and metal implant surface coatings. Zirconia (ZrO2) based materials exhibit high fracture toughness due to the stress induced martensitic transformation of tetragonal to monoclinic ZrO2. In theory, a composite material composed of HA and a reinforcing ZrO2 phase, combining the inherent bioactivity of HA with reinforcement from the ZrO2 is an attractive proposition in terms of load bearing bone replacement. The work contained herein attempts to improve the mechanical properties of HA through the addition of a ZrO2 phase and consolidation through two comparative sintering techniques, microwave and conventional sintering. The first objective was to investigate the effect of microwave sintering on physical, mechanical and chemical properties of Y2O3 (2-5 mol%) doped ZrO2 compositions compared with conventional sintering. Y2O3 content was altered through the attrition milling of commercial undoped monoclinic ZrO2 powders with co-precipitated Y2O3-doped ZrO2 powders and these were characterized using X-ray diffraction (XRD), particle size analysis (PSA), transmission electron microscopy (TEM) and BET. Comparative sintering was performed at temperatures of 1100, 1200 and 1300°C. Post sintering characterization included phase analysis (XRD), microstructural analysis using scanning electron microscopy (SEM), density measurements and mechanical testing, which included Young?s modulus, biaxial flexural testing and microhardness. Compositions containing 2 mol% Y2O3 microwave sintered at a temperature of 1300°C exhibited the greatest improvement, due to retention of tetragonal ZrO2, with a 5% increase in relative density compared with conventional sintering. Grain size analysis indicated that there was significant grain growth in microwave sintered samples (to d = 353nm) compared to their conventionally sintered counterparts (d = 200nm). Associated with this was a 22% increase in Young?s modulus to 220GPa, a 77% increase in Vicker?s Hardness up to 11.5GPa and a 165% increase in biaxial flexural strength up to 800MPa. Based on these observations, a reinforcing ZrO2 phase containing 2 and 3 mol % Y2O3 was decided upon for addition to HA. The second objective was to investigate the effect of microwave sintering on HA-ZrO2 composites containing a commercial HA powder and HA synthesized using a co-precipitation technique and ZrO2 with the optimum Y2O3 content for Y-TZP found in the initial stage. HA was precipitation synthesized at temperatures of 25 and 45°C and characterized using XRD, X-ray fluorescence (XRF), TEM and BET. Commercial HA composites containing 0, 5, 10, 20 & 40wt % ZrO2 additions and synthesized HA (S-HA)…

Advisors/Committee Members: Hampshire, Stuart, Towler, M.R..

Subjects/Keywords: hydroxyapatite; biocompatibility

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Reidy, C. (2010). Comparative sintering of zirconia and hydroxyapatite-zirconia composites. (Thesis). University of Limerick. Retrieved from http://hdl.handle.net/10344/1644

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Reidy, Colin. “Comparative sintering of zirconia and hydroxyapatite-zirconia composites.” 2010. Thesis, University of Limerick. Accessed January 17, 2021. http://hdl.handle.net/10344/1644.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Reidy, Colin. “Comparative sintering of zirconia and hydroxyapatite-zirconia composites.” 2010. Web. 17 Jan 2021.

Vancouver:

Reidy C. Comparative sintering of zirconia and hydroxyapatite-zirconia composites. [Internet] [Thesis]. University of Limerick; 2010. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/10344/1644.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Reidy C. Comparative sintering of zirconia and hydroxyapatite-zirconia composites. [Thesis]. University of Limerick; 2010. Available from: http://hdl.handle.net/10344/1644

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Illinois – Urbana-Champaign

11. Altun, Esra. The biocompatibility and characterization of aromatic thermosetting copolyester.

Degree: MS, Mechanical Engineering, 2018, University of Illinois – Urbana-Champaign

URL: http://hdl.handle.net/2142/101732

► The current designs of new biomaterials for bone substitutes or scaffolds focus on achieving biocompatibility and sufficient mechanical properties. In this thesis, we investigated the… (more)

▼ The current designs of new biomaterials for bone substitutes or scaffolds focus on achieving biocompatibility and sufficient mechanical properties. In this thesis, we investigated the biocompatibility of synthetic polymers called aromatic thermosetting copolyesters (ATSP) as potential biomaterials for bone replacements (implants). These materials are easy to manufacture and have good mechanical properties such as high tensile strength, and high wear resistance. They can be made into bulk, film, foams, and composites. In this thesis, we included all these forms and created a composite by infusing ATSP with 10wt% of hydroxyapatite (minerals of similar compositions as those found in bone). Homogenous distribution of the HA filler improves the physical properties of composite ATSP. In addition to this, having robust adhesive features with metals, high energy absorption limit, and promising tribological properties makes ATSP a strong candidate for different orthopedic implant applications. This research extended an earlier biocompatibility study of ATSP in which direct contact of fibroblasts cells was used to study of neat ATSP and ATSP blends with ultrahigh molecular weight polyethylene (UHMWPE) for total joint arthroplasty. The results demonstrated that cells were able to attach to ATSP, and there was no indication of cell death [1]. Since these previous results looked promising, in this thesis we conducted more extensive studies of the biocompatibity of ATSP. Chapter 1 describes the biocompatibility investigation of three different compositions (film, bulk, and foam) of neat and composite ATSP by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT assay) with human osteoblast cell line (hFOB 1.19 (ATCC® CRL 11372™)), and the results were obtained from the metabolic activity of hFOB 1.19 cells for 48 hours. The results which were either equal to or greater than 85% were accepted as non-cytotoxic, the values between 60% and 85% were defined as slightly cytotoxic, 30%– 59% were moderately cytotoxic and less than 30% were accepted severely cytotoxic. The results of metabolic activity by MTT showed that each group (film, bulk, and foam) of neat and composite ATSP samples did not demonstrate any toxicity at all concentrations (≥85%) except for neat film samples which showed slight toxicity (~75%). Overall the results for each group were consistent between neat and composite samples. Furthermore, the increase in the concentration did not change the results. The presence of HA was used to investigate the effect of HA on increasing the metabolic cell activity; however, there was no increase in cell activity with the presence of the HA. Chapter 2 highlights the neat and composite foams that were designed to analyze the effect of biomaterial physical features, including porosity and mineral content over the bone formation by human mesenchymal stem cells differentiation. The analysis was done by alamarBlue® and RT-PCR assays. The metabolic activity results of foam samples by alamarBlue® with MSCs showed that… Advisors/Committee Members: Jasiuk, Iwona (advisor).

Subjects/Keywords: Biocompatibility; Aromatic Thermosetting Copolyester; Cytotoxicity

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APA (6^th Edition):

Altun, E. (2018). The biocompatibility and characterization of aromatic thermosetting copolyester. (Thesis). University of Illinois – Urbana-Champaign. Retrieved from http://hdl.handle.net/2142/101732

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Altun, Esra. “The biocompatibility and characterization of aromatic thermosetting copolyester.” 2018. Thesis, University of Illinois – Urbana-Champaign. Accessed January 17, 2021. http://hdl.handle.net/2142/101732.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Altun, Esra. “The biocompatibility and characterization of aromatic thermosetting copolyester.” 2018. Web. 17 Jan 2021.

Vancouver:

Altun E. The biocompatibility and characterization of aromatic thermosetting copolyester. [Internet] [Thesis]. University of Illinois – Urbana-Champaign; 2018. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/2142/101732.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Altun E. The biocompatibility and characterization of aromatic thermosetting copolyester. [Thesis]. University of Illinois – Urbana-Champaign; 2018. Available from: http://hdl.handle.net/2142/101732

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Sydney

12. Yu, Young. Enhancing the biocompatibility of coronary artery stents .

Degree: 2015, University of Sydney

URL: http://hdl.handle.net/2123/16472

► Cardiovascular disease, in particular coronary artery disease is a leading cause of morbidity and mortality worldwide. Coronary artery disease occurs as a consequence of atherosclerosis.… (more)

▼ Cardiovascular disease, in particular coronary artery disease is a leading cause of morbidity and mortality worldwide. Coronary artery disease occurs as a consequence of atherosclerosis. Impediment to coronary blood flow causes myocardial ischemia, manifesting clinically as angina. Plaque rupture can lead to rapid vessel occlusion and myocardial necrosis. Revascularization (restoration of normal blood flow) can be achieved percutaneously with balloon angioplasty and coronary stent placement. Coronary stents are the most commonly implanted medical prostheses. To date the majority of commercially available stents are constructed from metallic alloys. Implantation of stents in the vasculature has two main biocompatibility issues 1) metals are thrombogenic, 2) stent deployment injures the vessel wall. Stent thrombosis and in stent restenosis are clinical consequences of stent thrombogenicity and vessel injury, respectively. Potent anti‐platelet agents and use of anti‐proliferative drug eluting stents reduce thrombogenicity and restenosis at the cost of increased bleeding and retardation of stent strut endothelialization leading to very late stent thrombosis. The interaction of biological systems with biomaterials is highly dependent on surface properties. Modification of the physical and chemical properties of the surface offers a simple and effective meanings to modulate the biological response to stents without altering the mechanical benefits that metallic alloys offer. Recently, plasma polymer deposition of thin films has been adapted for metallic substrates and three dimensional structures. These films reduce thrombogenicity and can attach biomolecules. One such molecule, recombinant human tropoelastin (rhTE) when attached to the films has been shown to enhance endothelial activity. Increasingly endothelial progenitor cells (EPCs) have been implicated in the maintenance of vascular health. Of particular interest is the capacity of these cells to participate in the healing of injured endothelium. Animal models demonstrate the ability of these cells to home in to sites of iatrogenic vessel injury and contribute to re‐endothelialisation. The goal of this thesis is to design a reproducible and scalable biocompatible coating platform for coronary stents. We explored the capacity of rhTE to support EPC activity followed by a mechanistic study of the nature of this interaction. Following this, we purpose built a plasma polymer film deposition chamber, optimizing for consistent and predictable film production. Nitrogen content of the plasma polymer films were progressively increased. A detailed physical, chemical and biological characterization of these nitrogenized films was carried out. There were several key findings from this thesis. We found rhTE supported EPC attachment, spreading and proliferation via an integrin mediated process. Using truncated rhTE constructs we were able to narrow down the site of interaction on rhTE to a region between N‐terminal domains 10 and 18. By increasing the flow of nitrogen…

Subjects/Keywords: Biocompatibility; Coronary Stent; Vascular

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Yu, Y. (2015). Enhancing the biocompatibility of coronary artery stents . (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/16472

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Yu, Young. “Enhancing the biocompatibility of coronary artery stents .” 2015. Thesis, University of Sydney. Accessed January 17, 2021. http://hdl.handle.net/2123/16472.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Yu, Young. “Enhancing the biocompatibility of coronary artery stents .” 2015. Web. 17 Jan 2021.

Vancouver:

Yu Y. Enhancing the biocompatibility of coronary artery stents . [Internet] [Thesis]. University of Sydney; 2015. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/2123/16472.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Yu Y. Enhancing the biocompatibility of coronary artery stents . [Thesis]. University of Sydney; 2015. Available from: http://hdl.handle.net/2123/16472

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Sydney

13. Hajian, Hamid. Improving The Biocompatibility of Vascular Grafts Using a Biomimicry Approach .

Degree: 2019, University of Sydney

URL: http://hdl.handle.net/2123/21021

► This thesis explores strategies to improve some facets of biocompatibility deficiencies of synthetic vascular grafts using a biomimicry approach by adding PF8, a fibrillin-1 recombinant… (more)

Subjects/Keywords: vascular; graft; bioengineering; biocompatibility; fibrillin

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hajian, H. (2019). Improving The Biocompatibility of Vascular Grafts Using a Biomimicry Approach . (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/21021

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hajian, Hamid. “Improving The Biocompatibility of Vascular Grafts Using a Biomimicry Approach .” 2019. Thesis, University of Sydney. Accessed January 17, 2021. http://hdl.handle.net/2123/21021.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hajian, Hamid. “Improving The Biocompatibility of Vascular Grafts Using a Biomimicry Approach .” 2019. Web. 17 Jan 2021.

Vancouver:

Hajian H. Improving The Biocompatibility of Vascular Grafts Using a Biomimicry Approach . [Internet] [Thesis]. University of Sydney; 2019. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/2123/21021.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hajian H. Improving The Biocompatibility of Vascular Grafts Using a Biomimicry Approach . [Thesis]. University of Sydney; 2019. Available from: http://hdl.handle.net/2123/21021

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Rutgers University

14. Lewitus, Dan, 1975-. Biomaterial strategies towards the development of next generation neural prosthetic devices.

Degree: PhD, Biomedical Engineering, 2011, Rutgers University

URL: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000057615

► Despite recent advances, there are major hurdles to overcome before cortical neural prosthetics can become a viable therapeutic strategy. The injury response to the insertion… (more)

▼ Despite recent advances, there are major hurdles to overcome before cortical neural prosthetics can become a viable therapeutic strategy. The injury response to the insertion of these devices results in eventual loss of recorded neuronal signal, preceded by inflammatory responses in the form of microglia, astrocyte, and macrophage aggregation at the injury site. Within days, gliosis, the glial encapsulation of the probe, excludes neurons and instigates progressive localized neurodegeneration. Variations in probe composition and designs are being investigated to enhance probe viability but the end result remains. In this work, two efforts were employed to resolve the problem of gliosis and its long-term consequences. Strategies integrating disciplines of chemistry, biology and engineering were employed to explore methods to advance the field of invasive cortical devices. The first effort involved the development of ultrafast degrading and ultrafast resorbing polymers based on a new family of tyrosine-derived polycarbonate terpolymers. Such polymers can enable the insertion of micronized devices into brain parenchyma, and once inserted, the polymers degrade and resorb in a benign manner, thus minimizing the acute response to the injury. The clinical relevance of such materials is the ability to insert devices that are smaller than the nominal size of neuronal soma, thus possibly relieving the probe from a chronic glial response. Various polymer chemistries were synthesized and characterized in vitro. Quantified analysis of the glial and neural response to the presence of the polymer in rat brain tissue confirmed our hypothesis of reduction in glial response when ultra-fast degrading and resorbing polymers are used. The retention of recording functionality of microelectrodes coated with this polymer, and its ability to deliver anti-inflammatory agents locally to the site of insertion were quantified as well. The second project is the development of completely new materials for use in neural electrodes. Current devices are either silicon or metal based. We developed carbon nanotube-polysaccharide composites. These materials have proven to be readily fabricated as microwires. Mechanical characterization showed the microwires are stiff when dry (allowing insertion) but soft and compliant when hydrated (for brain tissue compatibility). They are electrically conductive, and can be easily made bioactive through chemical conjugation of biologically active moieties, thus affecting cell-material interactions. The morphological, electrical, and biological properties of these novel materials were characterized for their potential to perform as neural electrodes. The effect of insertion of such materials into brain parenchyma has resulted in minimal glial response, while brain cell attachment could be altered through the conjugation of extracellular matrix proteins with the carbon nanotube-polysaccharide composite. Thus, future designs of neural prosthetics could highly benefit from the employment of such novel… Advisors/Committee Members: Lewitus, Dan, 1975- (author), Kohn, Joachim (chair), Shreiber, David (internal member), Shinbrot, Troy (internal member), Schachner, Melitta (outside member), Shain, William (outside member).

Subjects/Keywords: Neuroprostheses; Nanotubes; Polymers – Biocompatibility

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lewitus, Dan, 1. (2011). Biomaterial strategies towards the development of next generation neural prosthetic devices. (Doctoral Dissertation). Rutgers University. Retrieved from http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000057615

Chicago Manual of Style (16^th Edition):

Lewitus, Dan, 1975-. “Biomaterial strategies towards the development of next generation neural prosthetic devices.” 2011. Doctoral Dissertation, Rutgers University. Accessed January 17, 2021. http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000057615.

MLA Handbook (7^th Edition):

Lewitus, Dan, 1975-. “Biomaterial strategies towards the development of next generation neural prosthetic devices.” 2011. Web. 17 Jan 2021.

Vancouver:

Lewitus, Dan 1. Biomaterial strategies towards the development of next generation neural prosthetic devices. [Internet] [Doctoral dissertation]. Rutgers University; 2011. [cited 2021 Jan 17]. Available from: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000057615.

Council of Science Editors:

Lewitus, Dan 1. Biomaterial strategies towards the development of next generation neural prosthetic devices. [Doctoral Dissertation]. Rutgers University; 2011. Available from: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000057615

University of Hong Kong

15. 孙韬. Surface modification of titanium metal for medical applications.

Degree: 2010, University of Hong Kong

URL: http://hdl.handle.net/10722/143158

Subjects/Keywords: Titanium - Biocompatibility.; Titanium alloys - Biocompatibility.; Coatings - Biocompatibility.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

孙韬. (2010). Surface modification of titanium metal for medical applications. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/143158

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

孙韬. “Surface modification of titanium metal for medical applications.” 2010. Thesis, University of Hong Kong. Accessed January 17, 2021. http://hdl.handle.net/10722/143158.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

孙韬. “Surface modification of titanium metal for medical applications.” 2010. Web. 17 Jan 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

孙韬. Surface modification of titanium metal for medical applications. [Internet] [Thesis]. University of Hong Kong; 2010. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/10722/143158.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

孙韬. Surface modification of titanium metal for medical applications. [Thesis]. University of Hong Kong; 2010. Available from: http://hdl.handle.net/10722/143158

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

16. Hema., G.S. Biochemical Characterization and Bio-evaluation of Collagen and Collagen Peptides Extracted and Purified from Fish Skin: In vitro and In vivo Studies on Antiarthritic and Wound Healing Properties.

Degree: 2015, Cochin University of Science and Technology

URL: http://dyuthi.cusat.ac.in/purl/5041

►

In fish processing plants, there is huge amount of skin that is left as the waste. When this skin is taken and processed into fish… (more)

Subjects/Keywords: The Collagen Molecule; Fish Collagen; Biocompatibility; Biodegradability

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APA (6^th Edition):

Hema., G. S. (2015). Biochemical Characterization and Bio-evaluation of Collagen and Collagen Peptides Extracted and Purified from Fish Skin: In vitro and In vivo Studies on Antiarthritic and Wound Healing Properties. (Thesis). Cochin University of Science and Technology. Retrieved from http://dyuthi.cusat.ac.in/purl/5041

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hema., G S. “Biochemical Characterization and Bio-evaluation of Collagen and Collagen Peptides Extracted and Purified from Fish Skin: In vitro and In vivo Studies on Antiarthritic and Wound Healing Properties.” 2015. Thesis, Cochin University of Science and Technology. Accessed January 17, 2021. http://dyuthi.cusat.ac.in/purl/5041.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hema., G S. “Biochemical Characterization and Bio-evaluation of Collagen and Collagen Peptides Extracted and Purified from Fish Skin: In vitro and In vivo Studies on Antiarthritic and Wound Healing Properties.” 2015. Web. 17 Jan 2021.

Vancouver:

Hema. GS. Biochemical Characterization and Bio-evaluation of Collagen and Collagen Peptides Extracted and Purified from Fish Skin: In vitro and In vivo Studies on Antiarthritic and Wound Healing Properties. [Internet] [Thesis]. Cochin University of Science and Technology; 2015. [cited 2021 Jan 17]. Available from: http://dyuthi.cusat.ac.in/purl/5041.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hema. GS. Biochemical Characterization and Bio-evaluation of Collagen and Collagen Peptides Extracted and Purified from Fish Skin: In vitro and In vivo Studies on Antiarthritic and Wound Healing Properties. [Thesis]. Cochin University of Science and Technology; 2015. Available from: http://dyuthi.cusat.ac.in/purl/5041

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade Estadual de Campinas

17. Siniscalchi, Rodrigo Teixeira, 1971-. Efeitos biomecânicos e histológicos do recobrimento de tela de polipropileno com gel purificado de colágeno : estudo experimental: Biomechanical and histologic effects of coating a polypropylene mesh with a purified collagen gel : experimental study.

Degree: 2012, Universidade Estadual de Campinas

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/308653

► Abstract: Introduction: The synthetic material most currently used in the treatment of stress urinary incontinence (SUI) and vaginal wall prolapse, also known as pelvic organ… (more)

▼ Abstract: Introduction: The synthetic material most currently used in the treatment of stress urinary incontinence (SUI) and vaginal wall prolapse, also known as pelvic organ prolapse (POP) is the monofilament polypropylene mesh (PLP). However, complications related to tissue integration of these implants are relatively prevalent. Collagen is the main structural protein of mammals, which modulates inflammatory process, and can be used as an important healing agent and, accordingly, could improve the integration of the meshes. Objetives: To study the biomechanical and histological effects of PLP, coated with purified collagen gel, implanted in the subcutaneous tissue of adult rats. Methods: Twenty rats were used for histological study and other 20 for the biomechanical study. At one side of the abdominal wall, PLP fragment measuring 20x10 mm was implanted (Group I), and in the other side a mesh fragment with the same dimensions coated with purified collagen gel PLP+C) was implanted (Group II). According to the time of euthanasia (7, 30, 90 or 180 days) after implantation the animals from each group were divided into four subgroups of five animals each. The biomechanical study was performed with a precision tension meter with in bloc fresh abdominal wall sample containing the mesh. The mesh was pulled up in uniaxial direction until complete detachment of the tissue interface and the maximum load required for the detachment was analyzed in each group. In the histological study, it was examined characteristics of the acute and chronic inflammatory reaction, granulation tissue, granuloma formation, and foreign body reaction on slides stained with hematoxylin-eosin. The supramolecular organization of the collagen deposition around the meshes was studied with polarizing microscopy (birefringence analysis). Results: In biomechanical study it was observed that the adhesion of PLP to surrounding tissues increased significantly after coating with purified collagen gel, as shown in the analysis of the maximum load at the 7th (p=0.0016), 14th (p=0.0039), 90th (p=0.0009) and 180th (p=0.0029) days after implantation. It was considered in this research, that increased biocompatibility of PLP would be achieved when, in tissue interface, there was a reduction of the intensity of the inflammatory process. It was found that the acute and chronic inflammatory response, as well as the formation of granulation tissue were less intense, respectively p=0.004, p<0.001 and p=0.001 for PLP+C in the initial phase (7th and 14th days) and missing, as well as on the meshes not covered in late phase (90th and 180th days). Granulomatous inflammation was less significant seven days after implantation in animals of Group II (p=0.029) and in both groups, similarly, decreased over time showing no significant difference. The foreign body reaction was less intense in the initial phase in Group II (p<0.001) and similar between the groups in the late phase. In the birefringence analyses, it was noted a greater average density of brightness (transmittance) in… Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Riccetto, Cássio Luís Zanettini (advisor), Vidal, Benedicto de Campos, 1930- (coadvisor), Universidade Estadual de Campinas. Faculdade de Ciências Médicas (institution), Programa de Pós-Graduação em Ciências da Cirurgia (nameofprogram), Amaro, João Luiz (committee member), Lorenzetti, Fabio (committee member), Reis, Leonardo Oliveira (committee member), Maciel, Luiz Carlos (committee member).

Subjects/Keywords: Colágeno; Biocompatibilidade; Surgical mesh; Collagen; Biocompatibility

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APA (6^th Edition):

Siniscalchi, Rodrigo Teixeira, 1. (2012). Efeitos biomecânicos e histológicos do recobrimento de tela de polipropileno com gel purificado de colágeno : estudo experimental: Biomechanical and histologic effects of coating a polypropylene mesh with a purified collagen gel : experimental study. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/308653

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Siniscalchi, Rodrigo Teixeira, 1971-. “Efeitos biomecânicos e histológicos do recobrimento de tela de polipropileno com gel purificado de colágeno : estudo experimental: Biomechanical and histologic effects of coating a polypropylene mesh with a purified collagen gel : experimental study.” 2012. Thesis, Universidade Estadual de Campinas. Accessed January 17, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/308653.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Siniscalchi, Rodrigo Teixeira, 1971-. “Efeitos biomecânicos e histológicos do recobrimento de tela de polipropileno com gel purificado de colágeno : estudo experimental: Biomechanical and histologic effects of coating a polypropylene mesh with a purified collagen gel : experimental study.” 2012. Web. 17 Jan 2021.

Vancouver:

Siniscalchi, Rodrigo Teixeira 1. Efeitos biomecânicos e histológicos do recobrimento de tela de polipropileno com gel purificado de colágeno : estudo experimental: Biomechanical and histologic effects of coating a polypropylene mesh with a purified collagen gel : experimental study. [Internet] [Thesis]. Universidade Estadual de Campinas; 2012. [cited 2021 Jan 17]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/308653.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Siniscalchi, Rodrigo Teixeira 1. Efeitos biomecânicos e histológicos do recobrimento de tela de polipropileno com gel purificado de colágeno : estudo experimental: Biomechanical and histologic effects of coating a polypropylene mesh with a purified collagen gel : experimental study. [Thesis]. Universidade Estadual de Campinas; 2012. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/308653

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Michigan

18. Cai, Wenyi. Novel Biocompatible/Antimicrobial Materials Based on Nitric Oxide Release/Generation.

Degree: PhD, Chemistry, 2013, University of Michigan

URL: http://hdl.handle.net/2027.42/100090

► Thrombus formation and bacterial infection are two major problems that are associated with indwelling biomedical devices. In this dissertation work, coatings that are capable of… (more)

▼ Thrombus formation and bacterial infection are two major problems that are associated with indwelling biomedical devices. In this dissertation work, coatings that are capable of releasing or generating nitric oxide (NO), a potent anti-platelet and antimicrobial agent, have been developed to solve the biocompatibility issues. First, diazeniumdiolate doped-poly(lactic-co-glycolic acid) (PLGA)-based NO release coatings with controllable NO release profiles can be prepared with lifetimes of up to 15 d at room temperature and 10 d at 37°C. The NO release coatings exhibit significant antibiofilm properties after one week incubation in a CDC biofilm reactor, which provided both renewable nutrient sources and shear forces. In particular, compared to a silicone rubber surface, an NO release film with a base layer of 30 wt% dibutyhexyldiamine diazeniumdiolate (DBHD/N2O2) mixed with poly(lactic acid) (PLL) exhibited ~ 98.4% reduction in biofilm biomass of S. aureus and ~ 99.9% reduction for E. coli at 37 °C. NO can also be generated from endogenous NO donors such as S-nitrosothiols (RSNOs) by utilizing catalytic materials. A carboxyl-ebselen-based layer-by-layer (LbL) film was fabricated by alternatively assembling carboxyl-ebselen linked polyethylenimine (e-PEI) and alginate (Alg) onto substrates followed by salt annealing and cross-linking. After soaking in sheep blood for 24 h, a polyurethane catheter coated with (e-PEI/Alg)50 exhibit an NO flux of 3×10-10 mol cm-2 min-1 in a reservoir containing physiological levels of RSNO and thiols. The LbL film is also capable of generating superoxide, a potent antimicrobial agent. In-vitro antimicrobial tests demonstrated that a (e-PEI/Alg)50 film is capable of killing 98.2 % E. coli in solution and reducing ~87% E. coli surface coverage within 2 h at 37°C. In addition, a novel CuO nanoparticle-doped polyurethane film with less leaching of copper and minimized toxicity issue compared with a similar film doped with Cu nanoparticles is prepared. The film is capable of catalytically generating NO for 16 days at 37 °C. With their proven potential antithrombotic or antimicrobial properties, the developed NO release and NO generation coatings are expected to improve the biocompatibility of indwelling surfaces, reduce the medical cost and save patients’ lives. Advisors/Committee Members: Meyerhoff, Mark E. (committee member), Schwendeman, Steven P. (committee member), Lehnert, Nicolai (committee member), Chen, Zhan (committee member), Xi, Chuanwu (committee member).

Subjects/Keywords: Biocompatibility; Antimicrobial; Nitric Oxide; Chemistry; Science

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APA (6^th Edition):

Cai, W. (2013). Novel Biocompatible/Antimicrobial Materials Based on Nitric Oxide Release/Generation. (Doctoral Dissertation). University of Michigan. Retrieved from http://hdl.handle.net/2027.42/100090

Chicago Manual of Style (16^th Edition):

Cai, Wenyi. “Novel Biocompatible/Antimicrobial Materials Based on Nitric Oxide Release/Generation.” 2013. Doctoral Dissertation, University of Michigan. Accessed January 17, 2021. http://hdl.handle.net/2027.42/100090.

MLA Handbook (7^th Edition):

Cai, Wenyi. “Novel Biocompatible/Antimicrobial Materials Based on Nitric Oxide Release/Generation.” 2013. Web. 17 Jan 2021.

Vancouver:

Cai W. Novel Biocompatible/Antimicrobial Materials Based on Nitric Oxide Release/Generation. [Internet] [Doctoral dissertation]. University of Michigan; 2013. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/2027.42/100090.

Council of Science Editors:

Cai W. Novel Biocompatible/Antimicrobial Materials Based on Nitric Oxide Release/Generation. [Doctoral Dissertation]. University of Michigan; 2013. Available from: http://hdl.handle.net/2027.42/100090

University of Oxford

19. Stepina, Nataliia. Biocompatible carbon nanotube/β-titanium alloy composite materials.

Degree: PhD, 2015, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:09d4a408-9624-45c2-a8a9-0f14fd2b2251 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.740784

► The thesis describes a study of the modifications of orthopaedic Ti-based substrates using nanomaterials, and the evaluation of their biocompatibility for further use as implant… (more)

▼ The thesis describes a study of the modifications of orthopaedic Ti-based substrates using nanomaterials, and the evaluation of their biocompatibility for further use as implant material, with the aim to develop new, biocompatible β-Ti/CNT composite materials. Traditionally, CNTs require the presence of a transition metal catalyst such as Fe, Ni, Co, for successful growth. Different aspects of a catalyst-assisted CVD MWCNTs growth on various Ti-based substrates including bulk, thin films and 3D porous scaffolds, have been investigated. Low concentrations of catalyst were deposited using spin coating on titanium substrates of various forms and shapes. A strong influence of the surface topography was observed. In contrast, no effect of the elemental composition of the substrate could be detected. To evaluate the biocompatibility of the newly created materials, cell culture studies using fetal human osteoblasts (fHobs) were performed. It was shown that β-Ti/MWCNTs samples possess good initial osteoblast attachment, but no long-term osteoblast activity. Hence the biocompatibility of isolated (i.e. without a Ti substrate) MWCNTs was studied, using MWCNT carpets and various types of MWCNTs buckypapers. All the samples revealed very low cell activity. While β-Ti/MWCNTs samples did not exhibit good biocompatibility, alternative β-Ti/TiC samples were synthesized with a simple CVD method and revealed good osteoblast response with increased mineralization. Moreover, good corrosion resistance and mechanical properties of β-Ti/TiC samples have been reported. Finally, successful method for non-catalytic CVD MWCNTs growth on Ti substrates was developed for the first time, thereby excluding potentially toxic catalysts from the implant material. CVD was performed with acetylene precursor on bulk titanium substrates etched with Piranha solution, which generated an appropriate surface to foster MWCNTs growth. A combination of the change in the surface roughness, improved hydrophilicity, and elemental composition of the surface as a result of the Piranha etching is likely to be responsible for the successful formation of MWCNTs.

Subjects/Keywords: 610.28; Nanotechnology; Materials; Carbon nanotubes; titanium; biocompatibility

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APA (6^th Edition):

Stepina, N. (2015). Biocompatible carbon nanotube/β-titanium alloy composite materials. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:09d4a408-9624-45c2-a8a9-0f14fd2b2251 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.740784

Chicago Manual of Style (16^th Edition):

Stepina, Nataliia. “Biocompatible carbon nanotube/β-titanium alloy composite materials.” 2015. Doctoral Dissertation, University of Oxford. Accessed January 17, 2021. http://ora.ox.ac.uk/objects/uuid:09d4a408-9624-45c2-a8a9-0f14fd2b2251 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.740784.

MLA Handbook (7^th Edition):

Stepina, Nataliia. “Biocompatible carbon nanotube/β-titanium alloy composite materials.” 2015. Web. 17 Jan 2021.

Vancouver:

Stepina N. Biocompatible carbon nanotube/β-titanium alloy composite materials. [Internet] [Doctoral dissertation]. University of Oxford; 2015. [cited 2021 Jan 17]. Available from: http://ora.ox.ac.uk/objects/uuid:09d4a408-9624-45c2-a8a9-0f14fd2b2251 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.740784.

Council of Science Editors:

Stepina N. Biocompatible carbon nanotube/β-titanium alloy composite materials. [Doctoral Dissertation]. University of Oxford; 2015. Available from: http://ora.ox.ac.uk/objects/uuid:09d4a408-9624-45c2-a8a9-0f14fd2b2251 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.740784

Deakin University

20. Sista, Subhash. Role of surface properties of titanium alloys on osteoblasts response.

Degree: 2012, Deakin University

URL: http://hdl.handle.net/10536/DRO/DU:30061579

► This thesis examined the behavior of osteoblast cells in response to material surfaces. Cell behavior at the cellular and molecular level on Ti and two… (more)

Subjects/Keywords: Osteoblast cells; Titanium alloys; Zirconium; Niobium; Biocompatibility

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APA (6^th Edition):

Sista, S. (2012). Role of surface properties of titanium alloys on osteoblasts response. (Thesis). Deakin University. Retrieved from http://hdl.handle.net/10536/DRO/DU:30061579

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sista, Subhash. “Role of surface properties of titanium alloys on osteoblasts response.” 2012. Thesis, Deakin University. Accessed January 17, 2021. http://hdl.handle.net/10536/DRO/DU:30061579.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sista, Subhash. “Role of surface properties of titanium alloys on osteoblasts response.” 2012. Web. 17 Jan 2021.

Vancouver:

Sista S. Role of surface properties of titanium alloys on osteoblasts response. [Internet] [Thesis]. Deakin University; 2012. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/10536/DRO/DU:30061579.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sista S. Role of surface properties of titanium alloys on osteoblasts response. [Thesis]. Deakin University; 2012. Available from: http://hdl.handle.net/10536/DRO/DU:30061579

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Deakin University

21. Wang, Yu. Surface modification of titanium for biomedical applications.

Degree: 2014, Deakin University

URL: http://hdl.handle.net/10536/DRO/DU:30074528

In this research, strontium (Sr) and surface modification were used to improve the biocompatibility of titanium (Ti) based implant materials. Advisors/Committee Members: Li Yuncang, Wen Cui`e, Hodgson Peter.

Subjects/Keywords: titanium implant materials; biocompatibility; strontium; surface modification

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wang, Y. (2014). Surface modification of titanium for biomedical applications. (Thesis). Deakin University. Retrieved from http://hdl.handle.net/10536/DRO/DU:30074528

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wang, Yu. “Surface modification of titanium for biomedical applications.” 2014. Thesis, Deakin University. Accessed January 17, 2021. http://hdl.handle.net/10536/DRO/DU:30074528.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wang, Yu. “Surface modification of titanium for biomedical applications.” 2014. Web. 17 Jan 2021.

Vancouver:

Wang Y. Surface modification of titanium for biomedical applications. [Internet] [Thesis]. Deakin University; 2014. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/10536/DRO/DU:30074528.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wang Y. Surface modification of titanium for biomedical applications. [Thesis]. Deakin University; 2014. Available from: http://hdl.handle.net/10536/DRO/DU:30074528

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Univerzitet u Beogradu

22. Prokić, Bogomir Bolka B., 1982-. Ispitivanje biokompatibilnosti funkcionalizovanih karbonskih vlakana u potkožnom i mišićnom tkivu kunića.

Degree: Fakultet veterinarske medicine, 2017, Univerzitet u Beogradu

URL: https://fedorabg.bg.ac.rs/fedora/get/o:16797/bdef:Content/get

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Veterinarska medicina - Hirurgija / Veterinary medicine - Surgery

U ovoj doktorskoj disertaciji upotrebljena su dobro okarakterisana komercijalna visokočvrsta karbonska vlakna (KV) marke Torayca (T300B,… (more)

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Veterinarska medicina - Hirurgija / Veterinary medicine - Surgery

U ovoj doktorskoj disertaciji upotrebljena su dobro okarakterisana komercijalna visokočvrsta karbonska vlakna (KV) marke Torayca (T300B, 6000-50B, No 2610622), debljine 4-6 m. Ova vlakna funkcionalizovana su tretiranjem HNO3 i KOH, što je značajno izmenilo sadržaj površinskih grupa. Biokompatibilnost tako funkcionalizovanih karbonskih vlakana ispitivana je na eksperimentalnim životinjama (kunići, varijetet činčila), a procenjivana je in vitro, na ćelijskim kulturama (fibroblastvoj i makrofagnoj), in vivo aplikacijom vlakana u potkožno tkivo i m. longissimus dorsi i primenom nuklearne magnetne rezonance (NMR). Rezultati ove doktorske disertacije pokazali su da ne postoji razlika u stepenu citotoksičnosti između modifikovanih i standardnih KV, koja je u ovom eksperimentu prvo procenjivana na osnovu testa vijabilnosti ćelija (kalorimetrijski MTT) i testa ćelijske adhezije (trodimenzionalna / 3D kultivacija ćelija u Matrigelu) na humanim fibroblastima kontinuirane ćelijske linije MRC-5. Međutim, ova istraživanja dopunjena su testovima na kulturi humane makrofagne linije U937, u kojima je procenjivana vijabilnost ćelija, internalizacija vlakana (fagocitoza) i produkcija proinflamatornih citokina, IL-1, IL6, IL-8 i TNF-. Ćelijska vijabilnost bila je nenarušena u kulturama humane makrofagne linije U937 ukoliko su se dodavala KV u koncentaciji od 125 g/ ml. Međutim, dodavanjem KV u koncentraciji od 250 g/ml ili 500 g/ml, dolazilo je do značajnog dozno-zavisnog linearnog smanjenja vijabilnosti ćelija kod sve tri primenjene grupe KV, i to naročito kod dodavanja baznih KV. Znatno veći broj makrofagnih ćelija fagocitovao je KV trerira bazom, u odnosu na fagocitozu standardnih i kiselih KV. Postojala je povećana koncentracija proinflamatornih citokina TNF- i IL-1 u supernatantima kulture humanih makrofaga linije U937 nakon dodavanja standardnih ili kiselih KV u koncentraciji od 125 g/ml, dok je dodavanje baznih KV u istoj koncentraciji uslovilo smanjenu produkciju ovih citokina. U istoj koncentraciji, standardna KV su uslovila značajno smanjenja sekrecije IL-8, a kisela i bazna KV izrazito povećanje sekrecije IL-6 i IL-8. Pri tome, vlakna tretirana kiselinom bila su snažniji stimulator sekrecije IL-8 iz makrofaga u odnosu na vlakna tretirana bazom...

Advisors/Committee Members: Krstić, Nikola, 1963-.

Subjects/Keywords: functionalized carbon fibers; biocompatibility; rabbits; soft tissue

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APA (6^th Edition):

Prokić, Bogomir Bolka B., 1. (2017). Ispitivanje biokompatibilnosti funkcionalizovanih karbonskih vlakana u potkožnom i mišićnom tkivu kunića. (Thesis). Univerzitet u Beogradu. Retrieved from https://fedorabg.bg.ac.rs/fedora/get/o:16797/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Prokić, Bogomir Bolka B., 1982-. “Ispitivanje biokompatibilnosti funkcionalizovanih karbonskih vlakana u potkožnom i mišićnom tkivu kunića.” 2017. Thesis, Univerzitet u Beogradu. Accessed January 17, 2021. https://fedorabg.bg.ac.rs/fedora/get/o:16797/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Prokić, Bogomir Bolka B., 1982-. “Ispitivanje biokompatibilnosti funkcionalizovanih karbonskih vlakana u potkožnom i mišićnom tkivu kunića.” 2017. Web. 17 Jan 2021.

Vancouver:

Prokić, Bogomir Bolka B. 1. Ispitivanje biokompatibilnosti funkcionalizovanih karbonskih vlakana u potkožnom i mišićnom tkivu kunića. [Internet] [Thesis]. Univerzitet u Beogradu; 2017. [cited 2021 Jan 17]. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:16797/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Prokić, Bogomir Bolka B. 1. Ispitivanje biokompatibilnosti funkcionalizovanih karbonskih vlakana u potkožnom i mišićnom tkivu kunića. [Thesis]. Univerzitet u Beogradu; 2017. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:16797/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Univerzitet u Beogradu

23. Opačić-Galić, Vanja N., 1969-. Ispitivanje biokompatibilnosti nanostrukturnih materijala na bazi aktivnih kalcijum silikatnih sistema i hidroksiapatita.

Degree: Stomatološki fakultet, 2016, Univerzitet u Beogradu

URL: https://fedorabg.bg.ac.rs/fedora/get/o:11033/bdef:Content/get

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Stomatologija - Kliničke stomatološke nauke / Dentistry - Clinical Dental Science

Usavršavanje materijala koji bi mogli da se koriste kao biološke «zamene» kosti,danas je jedna… (more)

Subjects/Keywords: nanomaterials; calcium silicate systems; hydroxyapatite; biocompatibility; bioactivity

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APA (6^th Edition):

Opačić-Galić, Vanja N., 1. (2016). Ispitivanje biokompatibilnosti nanostrukturnih materijala na bazi aktivnih kalcijum silikatnih sistema i hidroksiapatita. (Thesis). Univerzitet u Beogradu. Retrieved from https://fedorabg.bg.ac.rs/fedora/get/o:11033/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Opačić-Galić, Vanja N., 1969-. “Ispitivanje biokompatibilnosti nanostrukturnih materijala na bazi aktivnih kalcijum silikatnih sistema i hidroksiapatita.” 2016. Thesis, Univerzitet u Beogradu. Accessed January 17, 2021. https://fedorabg.bg.ac.rs/fedora/get/o:11033/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Opačić-Galić, Vanja N., 1969-. “Ispitivanje biokompatibilnosti nanostrukturnih materijala na bazi aktivnih kalcijum silikatnih sistema i hidroksiapatita.” 2016. Web. 17 Jan 2021.

Vancouver:

Opačić-Galić, Vanja N. 1. Ispitivanje biokompatibilnosti nanostrukturnih materijala na bazi aktivnih kalcijum silikatnih sistema i hidroksiapatita. [Internet] [Thesis]. Univerzitet u Beogradu; 2016. [cited 2021 Jan 17]. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:11033/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Opačić-Galić, Vanja N. 1. Ispitivanje biokompatibilnosti nanostrukturnih materijala na bazi aktivnih kalcijum silikatnih sistema i hidroksiapatita. [Thesis]. Univerzitet u Beogradu; 2016. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:11033/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Univerzitet u Beogradu

24. Lužajić Božinovski, Tijana, 1985- 21805415. Ispitivanje biokompatibilnosti nanokompozitnih hidrogelova srebro / polivinil-alkohol / grafen u potkožnom tkivu pacova, namenjenih biomedicinskoj primeni.

Degree: Fakultet veterinarske medicine, 2019, Univerzitet u Beogradu

URL: https://fedorabg.bg.ac.rs/fedora/get/o:19910/bdef:Content/get

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Veterinarska medicina - Histologija i embriologija / Veterinary Medicine - Histology and Embryology

Ova doktorska disertacija dizajnirana je u cilju da se ispita biokompatibilnost dva… (more)

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Veterinarska medicina - Histologija i embriologija / Veterinary Medicine - Histology and Embryology

Ova doktorska disertacija dizajnirana je u cilju da se ispita biokompatibilnost dva novosintetisana i prethodno in vitro okarakterisana hidrogela na bazi sintetskog polimera polivinil-alkohola − Ag/PVA i Ag/PVA/Gr, koji su namenjeni za izradu obloga za rane ili za implantate za meka tkiva. Polivinil-alkohol (PVA) je sintetički polimer koji se često koristi u biomedicini zbog svoje netoksičnosti, rastvorljivosti, biokompatibilnosti, elastičnosti i sposobnosti stvaranja reverzibilnih hidrogelova s visokom sposobnošću sorpcije. U poslednjih nekoliko godina, istraživanja se takođe fokusiraju na ugradnju grafena (Gr) u hidrogelove PVA kako bi se poboljšala njihova mehanička čvrstoća i trajnost. U inženjerstvu tkiva i regenerativnoj medicini posebno je važno da implantati i zavoji sadrže antiinflamatornu i antibakterijsku aktivnu komponentu kako bi zaštitili sterilnost rane ili sprečili infekciju u tkivu koje okružuje implantat. Poznato je da nanočestice srebra (eng. silver nanoparticles, AgNPs) poseduju odličnu antibakterijsku aktivnost, pa se zbog toga često koriste kao aktivna komponenta biomaterijala na bazi hidrogela od PVA. U cilju ispitivanja biokompatibilnosti novosintetisanih hidrogelova, praćena je reakcija mekog tkiva na duboko potkožno postavljene implantate od Ag/PVA i Ag/PVA/Gr i poređena je sa reakcijom na komercijalnu oblogu za rane na bazi kalcijum-alginata (Suprasorb©, Lohmann & Rauscher GmbH & Co. KG, Neuwied, Germany), koja je implantirana na identičan način. Procenjivan je tkivni iritacioni indeks (IrI) kao osnovna mera tkivnog odgovora na implantirane hidrogelove. Za određivanje stepena biokompatibilnosti merena je debljina vezivnotkivne kapsule oko implantiranih hidrogelova, broj inflamatornih ćelija, uključujući i Langerhansove džinovske ćelije, broj makrofaga u periimplantnoj zoni i njihova enevntualna migracija u biomaterijal, kao i brojnost krvnih sudova mikrovaskularnog korita oko zone implantacije. Posmatran je odnos proliferacije i apoptoze ćelijskih entiteta kože i potkožnog tkiva odgovornih za procese regeneracije i reparacije...

Advisors/Committee Members: Marković, Danica, 1962- 19664487.

Subjects/Keywords: biocompatibility; hydrogels; silver; poly(vinyl alcohol); graphen

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lužajić Božinovski, Tijana, 1. 2. (2019). Ispitivanje biokompatibilnosti nanokompozitnih hidrogelova srebro / polivinil-alkohol / grafen u potkožnom tkivu pacova, namenjenih biomedicinskoj primeni. (Thesis). Univerzitet u Beogradu. Retrieved from https://fedorabg.bg.ac.rs/fedora/get/o:19910/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lužajić Božinovski, Tijana, 1985- 21805415. “Ispitivanje biokompatibilnosti nanokompozitnih hidrogelova srebro / polivinil-alkohol / grafen u potkožnom tkivu pacova, namenjenih biomedicinskoj primeni.” 2019. Thesis, Univerzitet u Beogradu. Accessed January 17, 2021. https://fedorabg.bg.ac.rs/fedora/get/o:19910/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lužajić Božinovski, Tijana, 1985- 21805415. “Ispitivanje biokompatibilnosti nanokompozitnih hidrogelova srebro / polivinil-alkohol / grafen u potkožnom tkivu pacova, namenjenih biomedicinskoj primeni.” 2019. Web. 17 Jan 2021.

Vancouver:

Lužajić Božinovski, Tijana 12. Ispitivanje biokompatibilnosti nanokompozitnih hidrogelova srebro / polivinil-alkohol / grafen u potkožnom tkivu pacova, namenjenih biomedicinskoj primeni. [Internet] [Thesis]. Univerzitet u Beogradu; 2019. [cited 2021 Jan 17]. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:19910/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lužajić Božinovski, Tijana 12. Ispitivanje biokompatibilnosti nanokompozitnih hidrogelova srebro / polivinil-alkohol / grafen u potkožnom tkivu pacova, namenjenih biomedicinskoj primeni. [Thesis]. Univerzitet u Beogradu; 2019. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:19910/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Plymouth

25. Natesan, Kiruthika. Antibacterial nanoparticle-decorated carbon nanotube-reinforced calcium phosphate composites as bone implants.

Degree: PhD, 2018, University of Plymouth

URL: http://hdl.handle.net/10026.1/10605

► Hydroxyapatite (HA) is a biologically active ceramic used in surgery to replace bone. While HA promotes bone growth, it suffers from weak mechanical properties and… (more)

▼ Hydroxyapatite (HA) is a biologically active ceramic used in surgery to replace bone. While HA promotes bone growth, it suffers from weak mechanical properties and does not possess any antibacterial property. Multi walled carbon nanotubes (MWCNTs), as one of the strongest and stiffest materials, have the potential to strengthen and toughen HA, thus expanding the range of clinical uses for the material. Furthermore, Silver nanoparticles (Ag NPs) can be decorated to sidewalls of the MWCNTs which could be released over a period of time to prevent infection following surgery. This work sought to develop and characterise Ag NPs- MWCNTs – HA composites in four main areas: 1) production and characterisation of the composite, 2) evaluation of mechanical properties, 3) investigation of antimicrobial property and 4) assessment of biological response to in vitro cell culture. Pristine (p-MWCNTs) and acid treated MWCNTs (f-MWCNTs) were decorated with Ag NPs. In the presence of 0.5 wt % Ag NPs-MWCNTs, HA was precipitated by the wet precipitation method in the presence of either poly vinyl alcohol (PVA) or Hexadecyl trimethyl ammonium bromide (HTAB) as the surfactant. Composites were characterised using various techniques and the diameteral tensile strength and compressive strength of the composites were measured. The antibacterial effect of these composites was investigated against clinically relevant microbe, Staphylococcus aureus. To determine the ability of the HOB cells to differentiate and mineralize in the presence of the composite, HOB cells were cultured on the composites for 21 days. Gene expression studies was performed along with the biochemical assays and scanning electron microscopy was used for qualitative analysis. Pure HA was used as control in all the studies. The study revealed that both the MWCNTs and surfactants play a crucial role in the nucleation and growth of the HA. XRD and FTIR characterisation revealed that HA was the primary phase in all the synthesised powders. Composites made with f-MWCNTs were found to have better dispersion and better interaction with the HA compared to composites with p-MWCNTs. Although mechanical strength was improved in all the composites, p-MWCNTs composites exhibiting maximum strength. Antibacterial studies showed 80% bacterial reduction in the treatment composites compared to pure HA. The biocompatibility study showed reduced activity of the HOB cells, however, no significant difference was observed between the control and the treatments. This systematic study of the synthesis and properties of the Ag NPs- MWCNTs-HA composites has resulted in improved understanding of the production and processing of these materials and the effect of MWCNTs and silver nanoparticles on primary human osteoblast cells. Additionally, it has yielded interesting biocompatibility result favouring the use of MWCNTs in the development of implants. There is potential to translate Ag NPs-MWCNTs-HA composites into clinically approved product.

Subjects/Keywords: 617.9; Biomaterial; Bone Implant; Biocomposites; Antimicrobial; Biocompatibility

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APA (6^th Edition):

Natesan, K. (2018). Antibacterial nanoparticle-decorated carbon nanotube-reinforced calcium phosphate composites as bone implants. (Doctoral Dissertation). University of Plymouth. Retrieved from http://hdl.handle.net/10026.1/10605

Chicago Manual of Style (16^th Edition):

Natesan, Kiruthika. “Antibacterial nanoparticle-decorated carbon nanotube-reinforced calcium phosphate composites as bone implants.” 2018. Doctoral Dissertation, University of Plymouth. Accessed January 17, 2021. http://hdl.handle.net/10026.1/10605.

MLA Handbook (7^th Edition):

Natesan, Kiruthika. “Antibacterial nanoparticle-decorated carbon nanotube-reinforced calcium phosphate composites as bone implants.” 2018. Web. 17 Jan 2021.

Vancouver:

Natesan K. Antibacterial nanoparticle-decorated carbon nanotube-reinforced calcium phosphate composites as bone implants. [Internet] [Doctoral dissertation]. University of Plymouth; 2018. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/10026.1/10605.

Council of Science Editors:

Natesan K. Antibacterial nanoparticle-decorated carbon nanotube-reinforced calcium phosphate composites as bone implants. [Doctoral Dissertation]. University of Plymouth; 2018. Available from: http://hdl.handle.net/10026.1/10605

Hong Kong University of Science and Technology

26. Ding, Yonghui. The effects of surface patterning on platelet adhesion.

Degree: 2011, Hong Kong University of Science and Technology

URL: http://repository.ust.hk/ir/Record/1783.1-7986 ; https://doi.org/10.14711/thesis-b1155751 ; http://repository.ust.hk/ir/bitstream/1783.1-7986/1/th_redirect.html

► Biomaterial implants, such as bone implant and endovascular implant, are widely used inmodern medical therapies. However, the biocompatibility of these materials is still far from… (more)

▼ Biomaterial implants, such as bone implant and endovascular implant, are widely used inmodern medical therapies. However, the biocompatibility of these materials is still far from perfection, which might result in the failure of application and bring huge pain to patients. Note that blood is the first body fluid that contacts any implant and thus blood-material interactions have a strong influence in determining the subsequent biocompatibility of implants, particularly of endovascular implants. It is widely recognized that platelet adhesion/activation is a key event in thrombus development in the process of blood-material interactions. Therefore, manipulating platelet adhesion/activation is critical to improve the biocompatibility of endovascular implants. Previously, most of the researches were devoted to chemical modification of biomaterial surface to control platelet adhesion/activation, but little work focused on surface topography modification. This research project aims at investigating the correlations between surface patterning and platelet adhesion/activation. Micro-groove and pillar patterns were fabricated on silicon substrate by photolithography and micro-fabrication techniques. Micro-patterned surfaces were coated with titanium oxide (TiO₂) thin film by RF sputtering process. Platelet adhesion and activation on these patterned surfaces were quantified by lactate dehydrogenase (LDH) and P-selectin (GMP-140) assay, respectively. The morphology of adherent platelets was observed by scanning electron microscope (SEM). Experimental results showed that platelet adhesion and activation displayed a good correlation with surface wettability and surface contact area, which can be manipulated by surface patterning. Lower wettability and larger surface contact area appeared to account for higher levels of platelet adhesion and activation on some specific patterned surfaces. In addition, both the groove and the pillar patterns could enhance platelet adhesion and activation, as compared to flat surface. This study demonstrated that surface topography could be an effective factor to control platelet adhesion/activation besides the surface chemistry. The work will offer valuable guidance for designing new endovascular implants.

Subjects/Keywords: Biomedical materials ; Surfaces ; Blood platelets ; Biocompatibility

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APA (6^th Edition):

Ding, Y. (2011). The effects of surface patterning on platelet adhesion. (Thesis). Hong Kong University of Science and Technology. Retrieved from http://repository.ust.hk/ir/Record/1783.1-7986 ; https://doi.org/10.14711/thesis-b1155751 ; http://repository.ust.hk/ir/bitstream/1783.1-7986/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ding, Yonghui. “The effects of surface patterning on platelet adhesion.” 2011. Thesis, Hong Kong University of Science and Technology. Accessed January 17, 2021. http://repository.ust.hk/ir/Record/1783.1-7986 ; https://doi.org/10.14711/thesis-b1155751 ; http://repository.ust.hk/ir/bitstream/1783.1-7986/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ding, Yonghui. “The effects of surface patterning on platelet adhesion.” 2011. Web. 17 Jan 2021.

Vancouver:

Ding Y. The effects of surface patterning on platelet adhesion. [Internet] [Thesis]. Hong Kong University of Science and Technology; 2011. [cited 2021 Jan 17]. Available from: http://repository.ust.hk/ir/Record/1783.1-7986 ; https://doi.org/10.14711/thesis-b1155751 ; http://repository.ust.hk/ir/bitstream/1783.1-7986/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ding Y. The effects of surface patterning on platelet adhesion. [Thesis]. Hong Kong University of Science and Technology; 2011. Available from: http://repository.ust.hk/ir/Record/1783.1-7986 ; https://doi.org/10.14711/thesis-b1155751 ; http://repository.ust.hk/ir/bitstream/1783.1-7986/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Michigan Technological University

27. Guillory II, Roger J. DEGRADABLE ZINC MATERIAL CHARACTERISTICS AND ITS INFLUENCE ON BIOCOMPATIBILITY IN AN IN-VIVO MURINE MODEL.

Degree: PhD, Department of Biomedical Engineering, 2019, Michigan Technological University

URL: https://digitalcommons.mtu.edu/etdr/967

► Biodegradable stents based on zinc have been under development since their introduction in 2013. While metallic zinc is highly ductile, it unfortunately lacks the… (more)

Subjects/Keywords: Zinc; Biocompatibility; In-vivo; Degradable; Stent; Biomaterials

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APA (6^th Edition):

Guillory II, R. J. (2019). DEGRADABLE ZINC MATERIAL CHARACTERISTICS AND ITS INFLUENCE ON BIOCOMPATIBILITY IN AN IN-VIVO MURINE MODEL. (Doctoral Dissertation). Michigan Technological University. Retrieved from https://digitalcommons.mtu.edu/etdr/967

Chicago Manual of Style (16^th Edition):

Guillory II, Roger J. “DEGRADABLE ZINC MATERIAL CHARACTERISTICS AND ITS INFLUENCE ON BIOCOMPATIBILITY IN AN IN-VIVO MURINE MODEL.” 2019. Doctoral Dissertation, Michigan Technological University. Accessed January 17, 2021. https://digitalcommons.mtu.edu/etdr/967.

MLA Handbook (7^th Edition):

Guillory II, Roger J. “DEGRADABLE ZINC MATERIAL CHARACTERISTICS AND ITS INFLUENCE ON BIOCOMPATIBILITY IN AN IN-VIVO MURINE MODEL.” 2019. Web. 17 Jan 2021.

Vancouver:

Guillory II RJ. DEGRADABLE ZINC MATERIAL CHARACTERISTICS AND ITS INFLUENCE ON BIOCOMPATIBILITY IN AN IN-VIVO MURINE MODEL. [Internet] [Doctoral dissertation]. Michigan Technological University; 2019. [cited 2021 Jan 17]. Available from: https://digitalcommons.mtu.edu/etdr/967.

Council of Science Editors:

Guillory II RJ. DEGRADABLE ZINC MATERIAL CHARACTERISTICS AND ITS INFLUENCE ON BIOCOMPATIBILITY IN AN IN-VIVO MURINE MODEL. [Doctoral Dissertation]. Michigan Technological University; 2019. Available from: https://digitalcommons.mtu.edu/etdr/967

University of Minnesota

28. Phillips, Haley. Elucidating Glycopolycation Structure-Function Relationships For Improved Gene Therapy.

Degree: PhD, Chemistry, 2017, University of Minnesota

URL: http://hdl.handle.net/11299/206410

► The gene therapy field is devoted to treating disease by adding, altering, or inhibiting gene expression. This type of therapy holds great promise for the… (more)

Subjects/Keywords: Biocompatibility; Delivery; Glycopolymer; Nonviral; Polyplex; Transfection

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Phillips, H. (2017). Elucidating Glycopolycation Structure-Function Relationships For Improved Gene Therapy. (Doctoral Dissertation). University of Minnesota. Retrieved from http://hdl.handle.net/11299/206410

Chicago Manual of Style (16^th Edition):

Phillips, Haley. “Elucidating Glycopolycation Structure-Function Relationships For Improved Gene Therapy.” 2017. Doctoral Dissertation, University of Minnesota. Accessed January 17, 2021. http://hdl.handle.net/11299/206410.

MLA Handbook (7^th Edition):

Phillips, Haley. “Elucidating Glycopolycation Structure-Function Relationships For Improved Gene Therapy.” 2017. Web. 17 Jan 2021.

Vancouver:

Phillips H. Elucidating Glycopolycation Structure-Function Relationships For Improved Gene Therapy. [Internet] [Doctoral dissertation]. University of Minnesota; 2017. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/11299/206410.

Council of Science Editors:

Phillips H. Elucidating Glycopolycation Structure-Function Relationships For Improved Gene Therapy. [Doctoral Dissertation]. University of Minnesota; 2017. Available from: http://hdl.handle.net/11299/206410

29. 戸井田, 侑. Pulpal response to capping with MTA containing phosphorylated pullulan.

Degree: 博士(歯学), 歯学, 2019, Hokkaido University

URL: http://hdl.handle.net/2115/77147

► Direct pulp capping materials ideally promote the formation of dentin bridge. Mineral trioxide aggregate is mostly used for direct pulp capping. However, this material showed… (more)

Subjects/Keywords: Restorative dentistry; Adhesives; Bioengineering; Biocompatibility; Biomaterials

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

戸井田, �. (2019). Pulpal response to capping with MTA containing phosphorylated pullulan. (Doctoral Dissertation). Hokkaido University. Retrieved from http://hdl.handle.net/2115/77147

Chicago Manual of Style (16^th Edition):

戸井田, 侑. “Pulpal response to capping with MTA containing phosphorylated pullulan.” 2019. Doctoral Dissertation, Hokkaido University. Accessed January 17, 2021. http://hdl.handle.net/2115/77147.

MLA Handbook (7^th Edition):

戸井田, 侑. “Pulpal response to capping with MTA containing phosphorylated pullulan.” 2019. Web. 17 Jan 2021.

Vancouver:

戸井田 �. Pulpal response to capping with MTA containing phosphorylated pullulan. [Internet] [Doctoral dissertation]. Hokkaido University; 2019. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/2115/77147.

Council of Science Editors:

戸井田 �. Pulpal response to capping with MTA containing phosphorylated pullulan. [Doctoral Dissertation]. Hokkaido University; 2019. Available from: http://hdl.handle.net/2115/77147

University of Hong Kong

30. Chen, Shuyang. Biological aspects of some novel Ti-based alloys.

Degree: 2015, University of Hong Kong

URL: http://hdl.handle.net/10722/221008

Subjects/Keywords: Titanium alloys - Biocompatibility

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chen, S. (2015). Biological aspects of some novel Ti-based alloys. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/221008

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chen, Shuyang. “Biological aspects of some novel Ti-based alloys.” 2015. Thesis, University of Hong Kong. Accessed January 17, 2021. http://hdl.handle.net/10722/221008.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chen, Shuyang. “Biological aspects of some novel Ti-based alloys.” 2015. Web. 17 Jan 2021.

Vancouver:

Chen S. Biological aspects of some novel Ti-based alloys. [Internet] [Thesis]. University of Hong Kong; 2015. [cited 2021 Jan 17]. Available from: http://hdl.handle.net/10722/221008.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chen S. Biological aspects of some novel Ti-based alloys. [Thesis]. University of Hong Kong; 2015. Available from: http://hdl.handle.net/10722/221008

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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