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Brno University of Technology
1.
Bertolla, Luca.
Mechanical Reinforcement of Bioglass®-Based Scaffolds: Mechanical Reinforcement of Bioglass®-Based Scaffolds.
Degree: 2019, Brno University of Technology
URL: http://hdl.handle.net/11012/51852 
► Bioactive glasses exhibit unique characteristics as a material for bone tissue engineering. Unfortunately, their extensive application for the repair of load-bearing bone defects is still…
(more)
▼ Bioactive glasses exhibit unique characteristics as a
material for bone tissue engineering. Unfortunately, their extensive application for the repair of load-bearing bone defects is still limited by low mechanical strength and fracture toughness. The main aim of this work was two-fold: the reinforcement of brittle Bioglass®-based porous scaffolds and the production of bulk Bioglass® samples exhibiting enhanced mechanical properties. For the first task, scaffolds were coated by composite coating constituted by polyvinyl alcohol (PVA) and microfibrillated cellulose (MFC). The addition of PVA/MFC coating led to a 10 fold increase of compressive strength and a 20 fold increase of tensile strength in comparison with non-coated scaffolds. SEM observations of broken struts surfaces proved the reinforcing and toughening mechanism of the composite coating which was ascribed to crack bridging and fracture of cellulose fibrils. The mechanical properties of the coating
material were investigated by tensile testing of PVA/MFC stand–alone specimens. The stirring time of the PVA/MFC solution came out as a crucial parameter in order to achieve a more homogeneous dispersion of the fibres and consequently enhanced strength and stiffness. Numerical simulation of a PVA coated Bioglass® strut revealed the infiltration depth of the coating until the crack tip as the most effective criterion for the struts strengthening. Contact angle and linear viscosity measurements of PVA/MFC solutions showed that MFC causes a reduction in contact angle and a drastic increase in viscosity, indicating that a balance between these opposing effects must be achieved. Concerning the production of bulk samples, conventional furnace and spark plasma sintering technique was used. Spark plasma sintering performed without the assistance of mechanical pressure and at heating rates ranging from 100 to 300°C /min led to a
material having density close to theoretical one and fracture toughness nearly 4 times higher in comparison with conventional sintering. Fractographic analysis revealed the crack deflection as the main toughening mechanisms acting in the bulk Bioglass®. Time–dependent crack healing process was also observed. The further investigation on the non-equilibrium phases crystallized is required. All obtained results are discussed in detail and general recommendations for scaffolds with enhanced mechanical resistance are served.
Advisors/Committee Members: Dlouhý, Ivo (advisor), Prof. Dr.-Ing. habil. Aldo R. Boccaccini (referee), Kotoul, Michal (referee), Pabst, Willi (referee).
Subjects/Keywords: bioactive glass; scaffolds; composite material; mechanical properties; tensile test; SPS; bioactive glass; scaffolds; composite material; mechanical properties; tensile test; SPS
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APA (6th Edition):
Bertolla, L. (2019). Mechanical Reinforcement of Bioglass®-Based Scaffolds: Mechanical Reinforcement of Bioglass®-Based Scaffolds. (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/51852
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Bertolla, Luca. “Mechanical Reinforcement of Bioglass®-Based Scaffolds: Mechanical Reinforcement of Bioglass®-Based Scaffolds.” 2019. Thesis, Brno University of Technology. Accessed January 22, 2021.
http://hdl.handle.net/11012/51852.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Bertolla, Luca. “Mechanical Reinforcement of Bioglass®-Based Scaffolds: Mechanical Reinforcement of Bioglass®-Based Scaffolds.” 2019. Web. 22 Jan 2021.
Vancouver:
Bertolla L. Mechanical Reinforcement of Bioglass®-Based Scaffolds: Mechanical Reinforcement of Bioglass®-Based Scaffolds. [Internet] [Thesis]. Brno University of Technology; 2019. [cited 2021 Jan 22].
Available from: http://hdl.handle.net/11012/51852.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Bertolla L. Mechanical Reinforcement of Bioglass®-Based Scaffolds: Mechanical Reinforcement of Bioglass®-Based Scaffolds. [Thesis]. Brno University of Technology; 2019. Available from: http://hdl.handle.net/11012/51852
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
2.
Hueliton Wilian Kido.
Biocompatibilidade da vitrocêramica bioativa (Biosilicato): análises in vitro e in vivo.
Degree: 2011, Universidade Federal de São Carlos
URL: http://www.bdtd.ufscar.br/htdocs/tedeSimplificado//tde_busca/arquivo.php?codArquivo=5009
► Devido a limitada disponibilidade de osso autógeno e dos riscos associados ao uso de osso alógeno, novos materiais sintéticos vêm sendo desenvolvidos com o objetivo…
(more)
▼ Devido a limitada disponibilidade de osso autógeno e dos riscos associados ao uso de osso alógeno, novos materiais sintéticos vêm sendo desenvolvidos com o objetivo de substituir o tecido ósseo perdido em decorrência de traumatismos ou processos patológicos. Os materiais bioativos na forma de scaffolds são materiais sintéticos promissores para enxertia óssea. Vários estudos sugerem que estes biomateriais são capazes de estimular a proliferação de osteoblastos e a osteogênese no local da fratura. No entanto, a viabilização destes biomateriais a uma aplicação clínica requer o emprego de testes que avaliem a sua biocompatibilidade. Dentro deste contexto, o presente estudo teve como objetivo avaliar a biocompatibilidade do scaffold sintetizado a partir de uma vitrocerâmica bioativa totalmente cristalizada do sistema quaternário P2O5-Na2O-CaO-SiO2 (Biosilicato), por meio da análise histopatológica do biomaterial implantado no tecido subcutâneo de ratos, e pelas análises de citotoxicidade e genotoxicidade do biomaterial em cultura de células da linhagem OSTEO-1 e L929. A análise histopatológica do biomaterial foi realizada utilizando 65 ratos machos da linhagem Wistar (210-260 g), distribuídos aleatoriamente em dois grupos, Controle (n = 3 animais por período) e Biosilicato (n = 10 animais por período), avaliados em períodos distintos de 7, 15, 30, 45 e 60 dias. Os animais do grupo Biosilicato foram submetidos a uma cirurgia no tecido subcutâneo e receberam um implante de scaffold de Biosilicato. Os animais do grupo Controle foram submetidos à mesma cirurgia, mas não receberam o implante do biomaterial. A análise de citotoxicidade foi realizada para avaliar os efeitos dos produtos da lixiviação dos scaffolds de Biosilicato (extratos) na proliferação celular pelo ensaio MTT. Os extratos foram avaliados em várias concentrações (100, 50, 25 e 12,5%) em períodos experimentais de 24, 72 e 120 horas, utilizando duas linhagens celulares (OSTEO-1 e L929). A análise de genotoxicidade (ensaio cometa) foi realizada para avaliar os danos no DNA de células OSTEO-1 e L929 cultivadas em contato com scaffolds de Biosilicato em períodos distintos de 24, 72 e 96 horas. A análise estatística dos dados paramétricos foi realizada pelo teste de variância (ANOVA), seguido do post-hoc de Tukey, e a análise dos dados não paramétricos foi realizada pelo teste de Mann-Whitney. Ambos os testes estatísticos foram realizados com nível de significância de 5%. Os resultados da análise histopatológica demonstraram que os animais do grupo Controle não apresentaram processo inflamatório, tecido necrótico ou tecido fibroso. Já os animais do grupo Biosilicato apresentaram um tecido de granulação após 7 dias de implantação e nos demais períodos (15, 30, 45 e 60 dias) apresentaram um processo inflamatório crônico de corpo estranho, marcado pela presença de tecido fibroso e células gigantes multinucleadas. Em todos os animais avaliados não foi evidenciado foco de infecção ou tecido necrótico. Na análise de citotoxicidade foi observado que os extratos dos…
Advisors/Committee Members: Oscar Peitl Filho.
Subjects/Keywords: Biotecnologia; Scaffold; Biomateriais; biocompatibilidade; reposta tecidual; material bioativo; MORFOLOGIA; biocompatibility; tissue response; bioactive material; scaffold; biomaterial
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APA (6th Edition):
Kido, H. W. (2011). Biocompatibilidade da vitrocêramica bioativa (Biosilicato): análises in vitro e in vivo. (Thesis). Universidade Federal de São Carlos. Retrieved from http://www.bdtd.ufscar.br/htdocs/tedeSimplificado//tde_busca/arquivo.php?codArquivo=5009
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Kido, Hueliton Wilian. “Biocompatibilidade da vitrocêramica bioativa (Biosilicato): análises in vitro e in vivo.” 2011. Thesis, Universidade Federal de São Carlos. Accessed January 22, 2021.
http://www.bdtd.ufscar.br/htdocs/tedeSimplificado//tde_busca/arquivo.php?codArquivo=5009.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Kido, Hueliton Wilian. “Biocompatibilidade da vitrocêramica bioativa (Biosilicato): análises in vitro e in vivo.” 2011. Web. 22 Jan 2021.
Vancouver:
Kido HW. Biocompatibilidade da vitrocêramica bioativa (Biosilicato): análises in vitro e in vivo. [Internet] [Thesis]. Universidade Federal de São Carlos; 2011. [cited 2021 Jan 22].
Available from: http://www.bdtd.ufscar.br/htdocs/tedeSimplificado//tde_busca/arquivo.php?codArquivo=5009.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Kido HW. Biocompatibilidade da vitrocêramica bioativa (Biosilicato): análises in vitro e in vivo. [Thesis]. Universidade Federal de São Carlos; 2011. Available from: http://www.bdtd.ufscar.br/htdocs/tedeSimplificado//tde_busca/arquivo.php?codArquivo=5009
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of North Texas
3.
Ho, Yee Hsien.
In Vitro Behavior of AZ31B Mg-Hydroxyapatite Metallic Matrix Composite Surface Fabricated via Friction Stir Processing.
Degree: 2016, University of North Texas
URL: https://digital.library.unt.edu/ark:/67531/metadc862762/
► Magnesium and its alloys have been considered for load-bearing implant materials due to their similar mechanical properties to the natural bone, excellent biocompatibility, good bioactivity,…
(more)
▼ Magnesium and its alloys have been considered for load-bearing implant materials due to their similar mechanical properties to the natural bone, excellent biocompatibility, good bioactivity, and biodegradation. Nevertheless, the uncontrollable corrosion rate in biological environment restrains their application. Hydroxyapatite (HA, Ca10(PO4)6(OH)2) is a widely used bio-ceramic which has bone-like mineral structure for bone fixation. Poor fracture toughness of HA makes it not suitable for load-bearing application as a bulk. Thus, HA is introduced into metallic surface in various forms for improving biocompatibility. Recently friction stir processing (FSP) has emerged as a surface modification tool for surface/substrate grain refinement and homogenization of microstructure in biomaterial. In the pressent efforts, Mg-nHA composite surface on with 5-20 wt% HA on Mg substrate were fabricated by FSP for biodegradation and bioactivity study. The results of electrochemical measurement indicated that lower amount (~5% wt%) of Ca in Mg matrix can enhance surface localized corrosion resistance. The effects of microstructure,the presence of HA particle and Mg-Ca intermetallic phase precipitates on in vitro behavior of Mg alloy were investigated by TEM, SEM, EDX,XRD ,and XPS. The detailed observations will be discussed during presentation.
Advisors/Committee Members: Dahotre, Narendra B., Mukherjee, Sundeep, Banerjee, Raj, Du, Jincheng, Zhao, Weihuan.
Subjects/Keywords: Magnesium alloy; Hydroxyapatite; Friction stir process; Biodegradable implant; Bioactive material; Corrosion; Surface wettability; Microstructure; Engineering, Materials Science; Engineering, Metallurgy
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4.
Ginsac, Nathalie.
Caractérisation de matériaux composite polyacide lactique-bioverre pour application dans la réparation osseuse : Characterization of polylactic acid- Bioglass® composites for bone repair applications.
Degree: Docteur es, Matériaux, 2011, INSA Lyon
URL: http://www.theses.fr/2011ISAL0020
► Ce travail de thèse porte sur la caractérisation d’un matériau composite polyacide lactique-bioverre pour application comme dispositif de réparation osseuse. Le bioverre étant trop fragile…
(more)
▼ Ce travail de thèse porte sur la caractérisation d’un matériau composite polyacide lactique-bioverre pour application comme dispositif de réparation osseuse. Le bioverre étant trop fragile pour être utilisé seul comme dispositif de réparation osseuse, celui-ci est associé à une matrice polymère résorbable permettant d’apporter le caractère bioactif à des matériaux pouvant être mis en forme par des procédés de plasturgie. Le matériau composite polyacide lactique-bioverre est ainsi mis en forme par injection à partir de granules élaborés par voie solvant. La caractérisation des propriétés de ce matériau composite a révélé une augmentation du module élastique avec l’ajout de charges, mais une diminution des contraintes maximales admissibles et de la déformation à la rupture. Les modifications des propriétés mécaniques ont été associées à une modification des propriétés de la matrice et notamment de sa masse moléculaire. Un autre mode d’élaboration par pressage à chaud a permis de limiter la dégradation du polymère. Une meilleure maitrise de la masse moléculaire du composite serait ainsi un moyen de contrôler sa cinétique de dégradation in vivo et ainsi d’adapter ses propriétés en fonction du cahier des charges des applications visées. Dans une seconde partie, l’effet du taux de bioverre sur le caractère bioactif du composite a été évalué par immersion dans un fluide biologique de composites chargés à 20, 30 et 50% (en masse de bioverre). Un scénario de cristallisation à la surface des différents composites a ainsi été proposé. Tous les composites se sont révélés bioactifs et d’autant plus que le taux de bioverre est élevé. Le composite chargé à 50% apparait ainsi comme le matériau le plus bioactif, mais sa vitesse de dégradation est très rapide. Ce matériau étant destiné à être implanté, une étude de biocompatibilité in vitro a été menée par culture de cellules ostéoblastiques à la surface des matériaux. Enfin la biocompatibilité du composite in vivo, son caractère biorésorbable et ostéoconducteur ont été évalués par implantation du matériau composite dans les tissus musculaires et osseux de lapins. Le caractère biocompatible, bioactif et ostéoconducteur du composite chargé à 30% en masse de bioverre en fait un candidat de choix pour les applications proposées.
The aim of this work was to evaluate polylactic acid- Bioglass® composites for bone repair applications. Bioglass being too brittle to be used alone for load bearing applications, our strategy was to incorporate bioactive Bioglass® particles into a bioresorbable polymer matrix processed by conventional manufacturing techniques. The composite were processed by injection moulding from granules prepared by a solvent route. The composites exhibit higher Young modulus but lower strength and strain to failure than polymer alone. This is attributed to a decrease of molecular weight of the polymer matrix during the different steps of the process. Another processing method (hot pressing) was used to limit the drop in molecular weight of the polymer matrix: it leads to…
Advisors/Committee Members: Chevalier, Jérôme (thesis director), Hartmann, Daniel (thesis director).
Subjects/Keywords: Biopolymère; Composite à matrice polymère; Bioverre; Polyacide lactique; Matériau biorésorbable; Matériau bioactif; Matériau biocompatible; Caractérisation du matériau; Implant osseux; Réparation osseuse; Biopolymer; Polymer matrix composite; Bioglass; Polylactic acid; Absorbable material; Bioactive material; Characterization of material; Bone implant; Bone repair
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APA (6th Edition):
Ginsac, N. (2011). Caractérisation de matériaux composite polyacide lactique-bioverre pour application dans la réparation osseuse : Characterization of polylactic acid- Bioglass® composites for bone repair applications. (Doctoral Dissertation). INSA Lyon. Retrieved from http://www.theses.fr/2011ISAL0020
Chicago Manual of Style (16th Edition):
Ginsac, Nathalie. “Caractérisation de matériaux composite polyacide lactique-bioverre pour application dans la réparation osseuse : Characterization of polylactic acid- Bioglass® composites for bone repair applications.” 2011. Doctoral Dissertation, INSA Lyon. Accessed January 22, 2021.
http://www.theses.fr/2011ISAL0020.
MLA Handbook (7th Edition):
Ginsac, Nathalie. “Caractérisation de matériaux composite polyacide lactique-bioverre pour application dans la réparation osseuse : Characterization of polylactic acid- Bioglass® composites for bone repair applications.” 2011. Web. 22 Jan 2021.
Vancouver:
Ginsac N. Caractérisation de matériaux composite polyacide lactique-bioverre pour application dans la réparation osseuse : Characterization of polylactic acid- Bioglass® composites for bone repair applications. [Internet] [Doctoral dissertation]. INSA Lyon; 2011. [cited 2021 Jan 22].
Available from: http://www.theses.fr/2011ISAL0020.
Council of Science Editors:
Ginsac N. Caractérisation de matériaux composite polyacide lactique-bioverre pour application dans la réparation osseuse : Characterization of polylactic acid- Bioglass® composites for bone repair applications. [Doctoral Dissertation]. INSA Lyon; 2011. Available from: http://www.theses.fr/2011ISAL0020
5.
Paulo Sérgio Bossini.
Efeitos do laser de baixa intensidade e do Biosilicato no reparo ósseo de ratas osteopênicas.
Degree: 2010, Universidade Federal de São Carlos
URL: http://www.bdtd.ufscar.br/htdocs/tedeSimplificado//tde_busca/arquivo.php?codArquivo=3767
► A osteoporose é uma doença esquelética sistêmica caracterizada por baixa densidade óssea e deterioração da microarquitetura do tecido ósseo, com consequente aumento do risco de…
(more)
▼ A osteoporose é uma doença esquelética sistêmica caracterizada por baixa densidade óssea e deterioração da microarquitetura do tecido ósseo, com consequente aumento do risco de fraturas. Fraturas de difícil consolidação são comumente encontradas em pacientes osteoporóticos com altos índices de morbidade e mortalidade. Dentro desse contexto, recursos biofísicos e bioquímicos têm sido estudados na tentativa de minimizar o tempo de consolidação óssea, destacando-se o uso da terapia laser de baixa intensidade (LLLT) e dos materiais bioativos. Vários estudos sugerem que ambos os recursos são capazes de estimular a proliferação de osteoblastos e a osteogênese no local da fratura, promovendo uma maior deposição de massa óssea, fundamental para o processo de consolidação. Diante disso, foram realizados dois estudos com o objetivo de verificar os efeitos da LLLT (Ga-Al-As, 830nm, 100mW), nas fluências de 60J/cm e 120J/cm e de uma vitrocerâmica bioativa (Biosilicato), utilizados independentemente ou associados, na consolidação de defeitos ósseos induzidos em tíbias de ratas osteopênicas. Um total de 60 ratas da linhagem Wistar (12 semanas de idade, 250g) foram submetidas à ovarectomia (OVX) e, sessenta dias após a indução, foi realizado um defeito ósseo em ambas as tíbias de todos os animais, os quais foram distribuídos aleatoriamente em seis grupos com dez animais cada. No primeiro estudo, foram avaliados os efeitos da LLLT sobre o reparo ósseo de ratas osteopênicas, a partir de três grupos experimentais: grupo controle com defeito ósseo sem tratamento (GC); grupo defeito ósseo tratado com laser 60J/cm (GL60) e grupo defeito ósseo tratado com laser 120J/cm (GL120). Os animais foram submetidos à irradiação laser em um único ponto sobre o defeito ósseo por sete sessões, em dias alternados. Nos grupos tratados com laser, em ambas as fluências, foi evidenciada uma maior quantidade de osso neoformado comparado ao controle. A análise de birrefringência demonstrou que os defeitos ósseos irradiados apresentaram maior deposição e melhor organização estrutural das fibras colágenas, principalmente no grupo tratado com laser na fluência de 120J/cm. A imunorreatividade à COX-2, CBFA-1 e VEGF foi detectada de forma similar nas duas fluências utilizadas e na análise biomecânica não houve diferença estatística significativa entre os grupos. Portanto, a LLLT, nas duas fluências utilizadas, estimulou o reparo ósseo em tíbias de ratas osteopênicas. No segundo estudo, foram analisados os efeitos do Biosilicato associado à LLLT no reparo ósseo de ratas osteopênicas, a partir de quatro grupos experimentais: grupo controle com defeito ósseo sem tratamento (GC); grupo defeito ósseo preenchido com Biosilicato (GB); grupo defeito ósseo preenchido com Biosilicato e irradiado com LLLT, com fluência de 60J/cm (GBL60); e grupo defeito ósseo preenchido com Biosilicato e irradiado com LLLT, com fluência de 120J/cm (GBL120). O Biosilicato foi utilizado na forma de partículas com granulometria de 180-212μm e os animais tratados com laser foram irradiados…
Advisors/Committee Members: Nivaldo Antonio Parizotto.
Subjects/Keywords: Fisioterapia; Laser de baixa intensidade; Materiais bioativos; Osteoporose; Reparo ósseo; Ovarectomia; FISIOTERAPIA E TERAPIA OCUPACIONAL; Bone repair; Low level laser therapy; Bioactive material; Osteoporosis; Ovariectomy
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APA ·
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APA (6th Edition):
Bossini, P. S. (2010). Efeitos do laser de baixa intensidade e do Biosilicato no reparo ósseo de ratas osteopênicas. (Thesis). Universidade Federal de São Carlos. Retrieved from http://www.bdtd.ufscar.br/htdocs/tedeSimplificado//tde_busca/arquivo.php?codArquivo=3767
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Bossini, Paulo Sérgio. “Efeitos do laser de baixa intensidade e do Biosilicato no reparo ósseo de ratas osteopênicas.” 2010. Thesis, Universidade Federal de São Carlos. Accessed January 22, 2021.
http://www.bdtd.ufscar.br/htdocs/tedeSimplificado//tde_busca/arquivo.php?codArquivo=3767.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Bossini, Paulo Sérgio. “Efeitos do laser de baixa intensidade e do Biosilicato no reparo ósseo de ratas osteopênicas.” 2010. Web. 22 Jan 2021.
Vancouver:
Bossini PS. Efeitos do laser de baixa intensidade e do Biosilicato no reparo ósseo de ratas osteopênicas. [Internet] [Thesis]. Universidade Federal de São Carlos; 2010. [cited 2021 Jan 22].
Available from: http://www.bdtd.ufscar.br/htdocs/tedeSimplificado//tde_busca/arquivo.php?codArquivo=3767.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Bossini PS. Efeitos do laser de baixa intensidade e do Biosilicato no reparo ósseo de ratas osteopênicas. [Thesis]. Universidade Federal de São Carlos; 2010. Available from: http://www.bdtd.ufscar.br/htdocs/tedeSimplificado//tde_busca/arquivo.php?codArquivo=3767
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
6.
Carla Roberta Tim.
Efeitos do laser de baixa intensidade e do Scaffold de Biosilicato no processo de reparação óssea.
Degree: 2011, Universidade Federal de São Carlos
URL: http://www.bdtd.ufscar.br/htdocs/tedeSimplificado//tde_busca/arquivo.php?codArquivo=4161
► Several resources have been studied in order to accelerate the process of bone repair. Among these resources, bioactive materials and low level laser therapy (LLLT)…
(more)
▼ Several resources have been studied in order to accelerate the process of bone repair. Among these resources, bioactive materials and low level laser therapy (LLLT) have gained prominence. Several studies suggest that both resources are able of stimulating osteoblast proliferation and osteogenesis at the fracture site, promoting a greater deposition of bone mass, which is fundamental for the consolidation process. Within this context, this project aimed to assess the effects of LLLT (_ = 830nm), with the fluencies of 120J/cm and scaffold Biosilicate, used associated or not, on consolidation of induced tibial bone defects in the rats. In this study it was used 40 male Wistar rats (3 months 250g) divided into four groups (with 10 animals each): group control bone defect without any treatment (GC), group bone defect irradiated with LLLT 830nm (GL); group bone defect treated with implantation of scaffolds Biosilicate (GB); group bone defect treated with implantation of scaffolds Biosilicate and LLLT 830nm (GBL). The animals were submitted to laser irradiation (Ga-As-Al, 830nm, 100mW) at a single point on the bone defect for eight sessions, on alternate days. The euthanasia of animals occurred at day 15 after surgery, 24 hours after the last laser treatment session. Morphological analysis revealed that the laser group, showed better tissue organization in relation to other groups. Furthermore, morphometric analysis revealed that the irradiated animals showed a higher amount of newly formed bone compared to the other groups. The expression of COX-2 and RUNX-2/CBFA-1 were higher in GB and GBL groups. Also, biomechanical analysis revealed no statistical differences among experimental groups. From the results obtained in this study, it is possible to suggest that both treatments had osteogenic potential 15 days after surgery, but the LLLT was more effective in bone repair when compared to the biomaterials, or even when the two treatment modalities were associated.
Vários recursos têm sido estudados com o intuito de acelerar o processo de reparação óssea. Dentre esses recursos, os materiais bioativos e a Terapia Laser de Baixa Intensidade (LLLT) vêm se destacando, vários estudos sugerem que ambos os recursos são capazes de estimular a proliferação de osteoblastos e a osteogênese no local da fratura, promovendo maior deposição de massa óssea, fundamental para o processo de consolidação. Dentro deste contexto, esse projeto teve como objetivo verificar os efeitos da LLLT (_ = 830nm), com fluência de 120J/cm e do scaffold de Biosilicato, utilizados independentemente ou associados na consolidação de defeitos ósseos induzidos em tíbias de ratos. Foram utilizados 40 ratos machos da linhagem Wistar (3 meses de idade 250 gramas) distribuídos em 4 grupos experimentais com 10 animais cada: grupo controle com defeito ósseo e sem tratamento (GC); grupo defeito ósseo tratado com Laser 830nm (GL); grupo defeito ósseo tratado com implante de scaffolds de Biosilicato (GB); grupo defeito ósseo tratado com implante de scaffolds de Biosilicato…
Advisors/Committee Members: Ana Cláudia Muniz Renno.
Subjects/Keywords: Laser de baixa intensidade; Biomateriais; Tecido ósseo; Defeito ósseo; Biomateriais; FISIOTERAPIA E TERAPIA OCUPACIONAL; Bone repair; Biotecnologia; Reparo ósseo; Bone defect; Low level laser therapy; Bioactive material
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APA (6th Edition):
Tim, C. R. (2011). Efeitos do laser de baixa intensidade e do Scaffold de Biosilicato no processo de reparação óssea. (Thesis). Universidade Federal de São Carlos. Retrieved from http://www.bdtd.ufscar.br/htdocs/tedeSimplificado//tde_busca/arquivo.php?codArquivo=4161
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Tim, Carla Roberta. “Efeitos do laser de baixa intensidade e do Scaffold de Biosilicato no processo de reparação óssea.” 2011. Thesis, Universidade Federal de São Carlos. Accessed January 22, 2021.
http://www.bdtd.ufscar.br/htdocs/tedeSimplificado//tde_busca/arquivo.php?codArquivo=4161.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Tim, Carla Roberta. “Efeitos do laser de baixa intensidade e do Scaffold de Biosilicato no processo de reparação óssea.” 2011. Web. 22 Jan 2021.
Vancouver:
Tim CR. Efeitos do laser de baixa intensidade e do Scaffold de Biosilicato no processo de reparação óssea. [Internet] [Thesis]. Universidade Federal de São Carlos; 2011. [cited 2021 Jan 22].
Available from: http://www.bdtd.ufscar.br/htdocs/tedeSimplificado//tde_busca/arquivo.php?codArquivo=4161.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Tim CR. Efeitos do laser de baixa intensidade e do Scaffold de Biosilicato no processo de reparação óssea. [Thesis]. Universidade Federal de São Carlos; 2011. Available from: http://www.bdtd.ufscar.br/htdocs/tedeSimplificado//tde_busca/arquivo.php?codArquivo=4161
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Michigan Technological University
7.
Pinnaratip, Rattapol.
EFFECT OF SILICA MICRO/NANO PARTICLES INCORPORATION OVER BIOINSPIRED POLY (ETHYLENE GLYCOL)-BASED ADHESIVE HYDROGEL.
Degree: MS, Department of Biomedical Engineering, 2017, Michigan Technological University
URL: https://digitalcommons.mtu.edu/etdr/534
► Cell infiltration is one of the most important characteristics of a degradable and bioactive biomaterial. Poly (ethylene glycol) (PEG), as one of the most…
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▼ Cell infiltration is one of the most important characteristics of a degradable and
bioactive biomaterial. Poly (ethylene glycol) (PEG), as one of the most commonly used polymer in medicine, also faces such problems. This issue also prevalence in PEG derivatives such as poly (ethylene glycol)-glutaric acid-dopamine (PEG-GA-DM) which is a versatile bioadhesive. As a promising bioadhesive system that can be used and modified to suit various type of applications, modification to overcome cellular infiltration and degradation issues will help further expand the usefulness of the
material in tissue repair application. The degradation issue is already preliminary solved by introducing ester linkage through carboxylic acid functionalization via glutaric acid incorporation. However, the resulting degradation rate is still not ideal. To further modify the porosity, pore structure, and degradation rate of the polymer, various types of non-crystalline silica particles were introduced into the polymer network. The benefit of including silica particles into the gel system may not limited only to the degradation and pore structure. One of the most interesting effects that this ceramic
material may contain is its ability to release silica byproduct, specifically hydrolyzed silica or orthosilicic acid. Orthosilicic acid was proved to positively affect collagenous extracellular matrix formation as well as improves keratin and collagen based organ’s health. Using various formulations, a number of PEG-GA-DA and silica composite improvements were investigated. The silica’s contributions to a number of changes include shortened gelation time, increased mechanical strength, faster initial degradation, higher structural stability after degradation, and, ultimately, change in porous structure. It is interesting that PEG-GA-DA silica composite not only provided improvement for the PEG network but also provide benefit for innate property of silica particle. With silicic acid as degraded product, the composite also facilitates extracellular matrix formation as well as therapeutic macrophages recruitment.
Advisors/Committee Members: Rupak M. Rajachar, Bruce P. Lee.
Subjects/Keywords: Silica particle; PEG; adhesive; bioactive material; poly(ethylene glycol); Biomaterials; Molecular, Cellular, and Tissue Engineering; Other Biomedical Engineering and Bioengineering; Polymer Science
Record Details
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Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Pinnaratip, R. (2017). EFFECT OF SILICA MICRO/NANO PARTICLES INCORPORATION OVER BIOINSPIRED POLY (ETHYLENE GLYCOL)-BASED ADHESIVE HYDROGEL. (Masters Thesis). Michigan Technological University. Retrieved from https://digitalcommons.mtu.edu/etdr/534
Chicago Manual of Style (16th Edition):
Pinnaratip, Rattapol. “EFFECT OF SILICA MICRO/NANO PARTICLES INCORPORATION OVER BIOINSPIRED POLY (ETHYLENE GLYCOL)-BASED ADHESIVE HYDROGEL.” 2017. Masters Thesis, Michigan Technological University. Accessed January 22, 2021.
https://digitalcommons.mtu.edu/etdr/534.
MLA Handbook (7th Edition):
Pinnaratip, Rattapol. “EFFECT OF SILICA MICRO/NANO PARTICLES INCORPORATION OVER BIOINSPIRED POLY (ETHYLENE GLYCOL)-BASED ADHESIVE HYDROGEL.” 2017. Web. 22 Jan 2021.
Vancouver:
Pinnaratip R. EFFECT OF SILICA MICRO/NANO PARTICLES INCORPORATION OVER BIOINSPIRED POLY (ETHYLENE GLYCOL)-BASED ADHESIVE HYDROGEL. [Internet] [Masters thesis]. Michigan Technological University; 2017. [cited 2021 Jan 22].
Available from: https://digitalcommons.mtu.edu/etdr/534.
Council of Science Editors:
Pinnaratip R. EFFECT OF SILICA MICRO/NANO PARTICLES INCORPORATION OVER BIOINSPIRED POLY (ETHYLENE GLYCOL)-BASED ADHESIVE HYDROGEL. [Masters Thesis]. Michigan Technological University; 2017. Available from: https://digitalcommons.mtu.edu/etdr/534
. 
Open Access Theses and Dissertations