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You searched for subject:(bioactivation). Showing records 1 – 28 of 28 total matches.

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University of California – San Francisco

1. Horng, Howard Tony. Studies on the Metabolic Activation of Mefenamic Acid: Characterization of the Acyl-Linked Metabolite, Mefenamyl-Adenylate.

Degree: Bioengineering, 2012, University of California – San Francisco

 Mefenamic acid, (MFA), a nonsteroidal anti-inflammatory drug, is metabolized to MFA-1-O-acyl-glucuronide (MFA-1-O-Gluc), a chemically-reactive conjugate implicated in the formation of protein-adducts and the potential toxicity… (more)

Subjects/Keywords: Pharmaceutical sciences; Bioactivation

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APA (6th Edition):

Horng, H. T. (2012). Studies on the Metabolic Activation of Mefenamic Acid: Characterization of the Acyl-Linked Metabolite, Mefenamyl-Adenylate. (Thesis). University of California – San Francisco. Retrieved from http://www.escholarship.org/uc/item/9644j05n

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Horng, Howard Tony. “Studies on the Metabolic Activation of Mefenamic Acid: Characterization of the Acyl-Linked Metabolite, Mefenamyl-Adenylate.” 2012. Thesis, University of California – San Francisco. Accessed June 19, 2019. http://www.escholarship.org/uc/item/9644j05n.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Horng, Howard Tony. “Studies on the Metabolic Activation of Mefenamic Acid: Characterization of the Acyl-Linked Metabolite, Mefenamyl-Adenylate.” 2012. Web. 19 Jun 2019.

Vancouver:

Horng HT. Studies on the Metabolic Activation of Mefenamic Acid: Characterization of the Acyl-Linked Metabolite, Mefenamyl-Adenylate. [Internet] [Thesis]. University of California – San Francisco; 2012. [cited 2019 Jun 19]. Available from: http://www.escholarship.org/uc/item/9644j05n.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Horng HT. Studies on the Metabolic Activation of Mefenamic Acid: Characterization of the Acyl-Linked Metabolite, Mefenamyl-Adenylate. [Thesis]. University of California – San Francisco; 2012. Available from: http://www.escholarship.org/uc/item/9644j05n

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Penn State University

2. Borland, Michael Gregory. PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR BETA/DELTA MODULATES ARYL HYDROCARBON RECEPTOR-DEPENDENT SIGNALING AND SKIN CARCINOGENESIS.

Degree: PhD, Biochemistry, Microbiology, and Molecular Biology, 2010, Penn State University

 Since its identification in the early 1990fs, the physiological roles of the nuclear hormone receptor peroxisome proliferator-activated receptor-ƒÀ/ƒÂ (PPARƒÀ/ƒÂ) have become better understood. This ligand-activated… (more)

Subjects/Keywords: PPARBeta/Delta; AHR; PAH; Bioactivation; Skin carcinogenesis

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APA (6th Edition):

Borland, M. G. (2010). PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR BETA/DELTA MODULATES ARYL HYDROCARBON RECEPTOR-DEPENDENT SIGNALING AND SKIN CARCINOGENESIS. (Doctoral Dissertation). Penn State University. Retrieved from https://etda.libraries.psu.edu/catalog/11381

Chicago Manual of Style (16th Edition):

Borland, Michael Gregory. “PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR BETA/DELTA MODULATES ARYL HYDROCARBON RECEPTOR-DEPENDENT SIGNALING AND SKIN CARCINOGENESIS.” 2010. Doctoral Dissertation, Penn State University. Accessed June 19, 2019. https://etda.libraries.psu.edu/catalog/11381.

MLA Handbook (7th Edition):

Borland, Michael Gregory. “PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR BETA/DELTA MODULATES ARYL HYDROCARBON RECEPTOR-DEPENDENT SIGNALING AND SKIN CARCINOGENESIS.” 2010. Web. 19 Jun 2019.

Vancouver:

Borland MG. PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR BETA/DELTA MODULATES ARYL HYDROCARBON RECEPTOR-DEPENDENT SIGNALING AND SKIN CARCINOGENESIS. [Internet] [Doctoral dissertation]. Penn State University; 2010. [cited 2019 Jun 19]. Available from: https://etda.libraries.psu.edu/catalog/11381.

Council of Science Editors:

Borland MG. PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR BETA/DELTA MODULATES ARYL HYDROCARBON RECEPTOR-DEPENDENT SIGNALING AND SKIN CARCINOGENESIS. [Doctoral Dissertation]. Penn State University; 2010. Available from: https://etda.libraries.psu.edu/catalog/11381


North Carolina State University

3. Croom, Edward Lee. Human Hepatic Expression of CYP2B6: Developmental Pattern and In Vitro Bioactivation of Chlorpyrifos.

Degree: PhD, Toxicology, 2010, North Carolina State University

 CROOM, EDWARD LEE. Human Hepatic Expression of CYP2B6: Developmental Pattern and In Vitro Bioactivation of Chlorpyrifos. (Under the direction of Dr. Ernest Hodgson and the… (more)

Subjects/Keywords: bioactivation; chlorpyrifos; CYP2B6; CYP3A4; developmental expression

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APA (6th Edition):

Croom, E. L. (2010). Human Hepatic Expression of CYP2B6: Developmental Pattern and In Vitro Bioactivation of Chlorpyrifos. (Doctoral Dissertation). North Carolina State University. Retrieved from http://www.lib.ncsu.edu/resolver/1840.16/6156

Chicago Manual of Style (16th Edition):

Croom, Edward Lee. “Human Hepatic Expression of CYP2B6: Developmental Pattern and In Vitro Bioactivation of Chlorpyrifos.” 2010. Doctoral Dissertation, North Carolina State University. Accessed June 19, 2019. http://www.lib.ncsu.edu/resolver/1840.16/6156.

MLA Handbook (7th Edition):

Croom, Edward Lee. “Human Hepatic Expression of CYP2B6: Developmental Pattern and In Vitro Bioactivation of Chlorpyrifos.” 2010. Web. 19 Jun 2019.

Vancouver:

Croom EL. Human Hepatic Expression of CYP2B6: Developmental Pattern and In Vitro Bioactivation of Chlorpyrifos. [Internet] [Doctoral dissertation]. North Carolina State University; 2010. [cited 2019 Jun 19]. Available from: http://www.lib.ncsu.edu/resolver/1840.16/6156.

Council of Science Editors:

Croom EL. Human Hepatic Expression of CYP2B6: Developmental Pattern and In Vitro Bioactivation of Chlorpyrifos. [Doctoral Dissertation]. North Carolina State University; 2010. Available from: http://www.lib.ncsu.edu/resolver/1840.16/6156


University of Guelph

4. Boudreau, Jordache. Electrochemical Generation of Reactive Species and their Application as Chemotherapeutics .

Degree: 2012, University of Guelph

 A major limitation in developing a successful cancer treatment is the need for a distinction between normal and cancerous tissue. For solid tumors, this distinction… (more)

Subjects/Keywords: electrochemistry; toxicology; cancer biology; cyclophosphamide; acetaminophen; focal therapy; graphite; oxidation; bioactivation

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APA (6th Edition):

Boudreau, J. (2012). Electrochemical Generation of Reactive Species and their Application as Chemotherapeutics . (Thesis). University of Guelph. Retrieved from https://atrium.lib.uoguelph.ca/xmlui/handle/10214/3588

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Boudreau, Jordache. “Electrochemical Generation of Reactive Species and their Application as Chemotherapeutics .” 2012. Thesis, University of Guelph. Accessed June 19, 2019. https://atrium.lib.uoguelph.ca/xmlui/handle/10214/3588.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Boudreau, Jordache. “Electrochemical Generation of Reactive Species and their Application as Chemotherapeutics .” 2012. Web. 19 Jun 2019.

Vancouver:

Boudreau J. Electrochemical Generation of Reactive Species and their Application as Chemotherapeutics . [Internet] [Thesis]. University of Guelph; 2012. [cited 2019 Jun 19]. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/3588.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Boudreau J. Electrochemical Generation of Reactive Species and their Application as Chemotherapeutics . [Thesis]. University of Guelph; 2012. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/3588

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


University of Kansas

5. Goldman, Jennifer Lynn. IN VITRO HEPATIC OXIDATIVE BIOTRANSFORMATION OF TRIMETHOPRIM.

Degree: MS, Preventive Medicine and Public Health, 2015, University of Kansas

 Introduction: Trimethoprim-sulfamethoxazole (TMP-SMX) is a commonly used antibiotic often associated with idiosyncratic adverse drug reactions (IADRs). Historically, bioactivation of SMX to a reactive intermediate has… (more)

Subjects/Keywords: Pharmacology; Bioactivation; human liver microsomes; In vitro; Trimethoprim

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APA (6th Edition):

Goldman, J. L. (2015). IN VITRO HEPATIC OXIDATIVE BIOTRANSFORMATION OF TRIMETHOPRIM. (Masters Thesis). University of Kansas. Retrieved from http://hdl.handle.net/1808/22543

Chicago Manual of Style (16th Edition):

Goldman, Jennifer Lynn. “IN VITRO HEPATIC OXIDATIVE BIOTRANSFORMATION OF TRIMETHOPRIM.” 2015. Masters Thesis, University of Kansas. Accessed June 19, 2019. http://hdl.handle.net/1808/22543.

MLA Handbook (7th Edition):

Goldman, Jennifer Lynn. “IN VITRO HEPATIC OXIDATIVE BIOTRANSFORMATION OF TRIMETHOPRIM.” 2015. Web. 19 Jun 2019.

Vancouver:

Goldman JL. IN VITRO HEPATIC OXIDATIVE BIOTRANSFORMATION OF TRIMETHOPRIM. [Internet] [Masters thesis]. University of Kansas; 2015. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/1808/22543.

Council of Science Editors:

Goldman JL. IN VITRO HEPATIC OXIDATIVE BIOTRANSFORMATION OF TRIMETHOPRIM. [Masters Thesis]. University of Kansas; 2015. Available from: http://hdl.handle.net/1808/22543


University of Manchester

6. Squillaci, Bianca. Approaches to the Detection of Adducts Formed via the Covalent Binding of Reactive Metabolites to Proteins.

Degree: 2013, University of Manchester

 Approaches to the Detection of Adducts formed via the Covalent Binding of Reactive Metabolites to Proteins A thesis submitted to The University of Manchester for… (more)

Subjects/Keywords: covalent binding; mass spectrometry; reactive metabolites; biotransformation; liquid chromatography; bioactivation

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APA (6th Edition):

Squillaci, B. (2013). Approaches to the Detection of Adducts Formed via the Covalent Binding of Reactive Metabolites to Proteins. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:192258

Chicago Manual of Style (16th Edition):

Squillaci, Bianca. “Approaches to the Detection of Adducts Formed via the Covalent Binding of Reactive Metabolites to Proteins.” 2013. Doctoral Dissertation, University of Manchester. Accessed June 19, 2019. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:192258.

MLA Handbook (7th Edition):

Squillaci, Bianca. “Approaches to the Detection of Adducts Formed via the Covalent Binding of Reactive Metabolites to Proteins.” 2013. Web. 19 Jun 2019.

Vancouver:

Squillaci B. Approaches to the Detection of Adducts Formed via the Covalent Binding of Reactive Metabolites to Proteins. [Internet] [Doctoral dissertation]. University of Manchester; 2013. [cited 2019 Jun 19]. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:192258.

Council of Science Editors:

Squillaci B. Approaches to the Detection of Adducts Formed via the Covalent Binding of Reactive Metabolites to Proteins. [Doctoral Dissertation]. University of Manchester; 2013. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:192258


Universidade Nova

7. Grilo, Nádia Filipa Marques. Protein adducts from the anti-HIV drug abacavir – possible biomarkers of drug toxicity.

Degree: 2012, Universidade Nova

Dissertação para obtenção do Grau de Mestre em Genética Molecular e Biomedicina

While the benefits of combined antiretroviral therapy have revolutionized the life expectancy of… (more)

Subjects/Keywords: Abacavir; Aldehyde metabolite; Biomarker; Cardiotoxicity; Drug bioactivation; Hypersensitivity

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APA (6th Edition):

Grilo, N. F. M. (2012). Protein adducts from the anti-HIV drug abacavir – possible biomarkers of drug toxicity. (Thesis). Universidade Nova. Retrieved from http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/8203

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Grilo, Nádia Filipa Marques. “Protein adducts from the anti-HIV drug abacavir – possible biomarkers of drug toxicity.” 2012. Thesis, Universidade Nova. Accessed June 19, 2019. http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/8203.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Grilo, Nádia Filipa Marques. “Protein adducts from the anti-HIV drug abacavir – possible biomarkers of drug toxicity.” 2012. Web. 19 Jun 2019.

Vancouver:

Grilo NFM. Protein adducts from the anti-HIV drug abacavir – possible biomarkers of drug toxicity. [Internet] [Thesis]. Universidade Nova; 2012. [cited 2019 Jun 19]. Available from: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/8203.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Grilo NFM. Protein adducts from the anti-HIV drug abacavir – possible biomarkers of drug toxicity. [Thesis]. Universidade Nova; 2012. Available from: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/8203

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


University of Manchester

8. Squillaci, Bianca. Approaches to the detection of adducts formed via the covalent binding of reactive metabolites to proteins.

Degree: PhD, 2013, University of Manchester

 Metabolism of xenobiotic drug molecules can result in the formation of metabolites which are more chemically reactive than the parent drug from which they are… (more)

Subjects/Keywords: 540; liquid chromatography; biotransformation; bioactivation; mass spectrometry; covalent binding; reactive metabolites

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APA (6th Edition):

Squillaci, B. (2013). Approaches to the detection of adducts formed via the covalent binding of reactive metabolites to proteins. (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/approaches-to-the-detection-of-adducts-formed-via-the-covalent-binding-of-reactive-metabolites-to-proteins(3b4ccc97-ea77-40d1-bb2b-2c4e70a1424d).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.740246

Chicago Manual of Style (16th Edition):

Squillaci, Bianca. “Approaches to the detection of adducts formed via the covalent binding of reactive metabolites to proteins.” 2013. Doctoral Dissertation, University of Manchester. Accessed June 19, 2019. https://www.research.manchester.ac.uk/portal/en/theses/approaches-to-the-detection-of-adducts-formed-via-the-covalent-binding-of-reactive-metabolites-to-proteins(3b4ccc97-ea77-40d1-bb2b-2c4e70a1424d).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.740246.

MLA Handbook (7th Edition):

Squillaci, Bianca. “Approaches to the detection of adducts formed via the covalent binding of reactive metabolites to proteins.” 2013. Web. 19 Jun 2019.

Vancouver:

Squillaci B. Approaches to the detection of adducts formed via the covalent binding of reactive metabolites to proteins. [Internet] [Doctoral dissertation]. University of Manchester; 2013. [cited 2019 Jun 19]. Available from: https://www.research.manchester.ac.uk/portal/en/theses/approaches-to-the-detection-of-adducts-formed-via-the-covalent-binding-of-reactive-metabolites-to-proteins(3b4ccc97-ea77-40d1-bb2b-2c4e70a1424d).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.740246.

Council of Science Editors:

Squillaci B. Approaches to the detection of adducts formed via the covalent binding of reactive metabolites to proteins. [Doctoral Dissertation]. University of Manchester; 2013. Available from: https://www.research.manchester.ac.uk/portal/en/theses/approaches-to-the-detection-of-adducts-formed-via-the-covalent-binding-of-reactive-metabolites-to-proteins(3b4ccc97-ea77-40d1-bb2b-2c4e70a1424d).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.740246


University of Surrey

9. Brown, Lisa. Role of oxidative metabolism in the bioactivation of chemical teratogens : an in vitro study with rat embryo cells.

Degree: PhD, 1986, University of Surrey

 The potential role of embryonic cells in the IN VITRO bioactivation of teratogens was investigated, with limb bud mesenchyme cells, (LB), and mid brain cells,(CNS),… (more)

Subjects/Keywords: 572; Bioactivation of teratogens

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APA (6th Edition):

Brown, L. (1986). Role of oxidative metabolism in the bioactivation of chemical teratogens : an in vitro study with rat embryo cells. (Doctoral Dissertation). University of Surrey. Retrieved from http://epubs.surrey.ac.uk/848469/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377984

Chicago Manual of Style (16th Edition):

Brown, Lisa. “Role of oxidative metabolism in the bioactivation of chemical teratogens : an in vitro study with rat embryo cells.” 1986. Doctoral Dissertation, University of Surrey. Accessed June 19, 2019. http://epubs.surrey.ac.uk/848469/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377984.

MLA Handbook (7th Edition):

Brown, Lisa. “Role of oxidative metabolism in the bioactivation of chemical teratogens : an in vitro study with rat embryo cells.” 1986. Web. 19 Jun 2019.

Vancouver:

Brown L. Role of oxidative metabolism in the bioactivation of chemical teratogens : an in vitro study with rat embryo cells. [Internet] [Doctoral dissertation]. University of Surrey; 1986. [cited 2019 Jun 19]. Available from: http://epubs.surrey.ac.uk/848469/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377984.

Council of Science Editors:

Brown L. Role of oxidative metabolism in the bioactivation of chemical teratogens : an in vitro study with rat embryo cells. [Doctoral Dissertation]. University of Surrey; 1986. Available from: http://epubs.surrey.ac.uk/848469/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377984


Université Catholique de Louvain

10. Fatakanwa, Claver. Développement et validation in vitro de nouvelles prodrogues sélectives de l'hypoxie tumorale.

Degree: 2016, Université Catholique de Louvain

Le cancer figure parmi les principales causes de mortalité dans le monde. La chimiothérapie est l’une des méthodes les plus utilisées pour traiter le cancer.… (more)

Subjects/Keywords: In cellulo; Catalyse organométallique; Bioactivation; Cancer; Hypoxie tumorale; Prodrogue; Bioorthogonale

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APA (6th Edition):

Fatakanwa, C. (2016). Développement et validation in vitro de nouvelles prodrogues sélectives de l'hypoxie tumorale. (Thesis). Université Catholique de Louvain. Retrieved from http://hdl.handle.net/2078.1/175334

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Fatakanwa, Claver. “Développement et validation in vitro de nouvelles prodrogues sélectives de l'hypoxie tumorale.” 2016. Thesis, Université Catholique de Louvain. Accessed June 19, 2019. http://hdl.handle.net/2078.1/175334.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Fatakanwa, Claver. “Développement et validation in vitro de nouvelles prodrogues sélectives de l'hypoxie tumorale.” 2016. Web. 19 Jun 2019.

Vancouver:

Fatakanwa C. Développement et validation in vitro de nouvelles prodrogues sélectives de l'hypoxie tumorale. [Internet] [Thesis]. Université Catholique de Louvain; 2016. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/2078.1/175334.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Fatakanwa C. Développement et validation in vitro de nouvelles prodrogues sélectives de l'hypoxie tumorale. [Thesis]. Université Catholique de Louvain; 2016. Available from: http://hdl.handle.net/2078.1/175334

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

11. Santos, Iolanda Sofia de Morais. Bioactivação de fármacos mediada pela trametes versicolor lacase.

Degree: 2016, Repositório Científico do Instituto Politécnico de Lisboa

Trabalho final de mestrado para obtenção do grau de Mestre em Engenharia Química e Biológica

Este trabalho teve como objectivo avaliar a capacidade da enzima… (more)

Subjects/Keywords: Lacase; Fármacos; Bioactivação; Oxidação biomimética; Metabolitos reactivos; Laccase; Drugs; Bioactivation; Biomimetic oxidation; Reactive metabolites

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APA (6th Edition):

Santos, I. S. d. M. (2016). Bioactivação de fármacos mediada pela trametes versicolor lacase. (Thesis). Repositório Científico do Instituto Politécnico de Lisboa. Retrieved from https://www.rcaap.pt/detail.jsp?id=oai:repositorio.ipl.pt:10400.21/6995

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Santos, Iolanda Sofia de Morais. “Bioactivação de fármacos mediada pela trametes versicolor lacase.” 2016. Thesis, Repositório Científico do Instituto Politécnico de Lisboa. Accessed June 19, 2019. https://www.rcaap.pt/detail.jsp?id=oai:repositorio.ipl.pt:10400.21/6995.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Santos, Iolanda Sofia de Morais. “Bioactivação de fármacos mediada pela trametes versicolor lacase.” 2016. Web. 19 Jun 2019.

Vancouver:

Santos ISdM. Bioactivação de fármacos mediada pela trametes versicolor lacase. [Internet] [Thesis]. Repositório Científico do Instituto Politécnico de Lisboa; 2016. [cited 2019 Jun 19]. Available from: https://www.rcaap.pt/detail.jsp?id=oai:repositorio.ipl.pt:10400.21/6995.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Santos ISdM. Bioactivação de fármacos mediada pela trametes versicolor lacase. [Thesis]. Repositório Científico do Instituto Politécnico de Lisboa; 2016. Available from: https://www.rcaap.pt/detail.jsp?id=oai:repositorio.ipl.pt:10400.21/6995

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Penn State University

12. Su, Shengzhong. Transcriptional regulation of the human microsomal epoxide hydrolase gene (EPHX1) driven by a far upstream alternative promoter.

Degree: PhD, Molecular Toxicology, 2013, Penn State University

 Microsomal epoxide hydrolase (mEH) is an important metabolizing enzyme that plays roles in both detoxification and bioactivation of xenobiotics. Human mEH gene expression is subjected… (more)

Subjects/Keywords: Microsomal epoxide hydrolase; Nrf2; Xenobiotic metabolism; Bioactivation; Lung cancer; Sp1; Sp3; AhR

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APA (6th Edition):

Su, S. (2013). Transcriptional regulation of the human microsomal epoxide hydrolase gene (EPHX1) driven by a far upstream alternative promoter. (Doctoral Dissertation). Penn State University. Retrieved from https://etda.libraries.psu.edu/catalog/18909

Chicago Manual of Style (16th Edition):

Su, Shengzhong. “Transcriptional regulation of the human microsomal epoxide hydrolase gene (EPHX1) driven by a far upstream alternative promoter.” 2013. Doctoral Dissertation, Penn State University. Accessed June 19, 2019. https://etda.libraries.psu.edu/catalog/18909.

MLA Handbook (7th Edition):

Su, Shengzhong. “Transcriptional regulation of the human microsomal epoxide hydrolase gene (EPHX1) driven by a far upstream alternative promoter.” 2013. Web. 19 Jun 2019.

Vancouver:

Su S. Transcriptional regulation of the human microsomal epoxide hydrolase gene (EPHX1) driven by a far upstream alternative promoter. [Internet] [Doctoral dissertation]. Penn State University; 2013. [cited 2019 Jun 19]. Available from: https://etda.libraries.psu.edu/catalog/18909.

Council of Science Editors:

Su S. Transcriptional regulation of the human microsomal epoxide hydrolase gene (EPHX1) driven by a far upstream alternative promoter. [Doctoral Dissertation]. Penn State University; 2013. Available from: https://etda.libraries.psu.edu/catalog/18909


University of Washington

13. Wahlin, Michelle Diane. Defining the Relationship between the Bioactivation of Lapatinib by CYP3A and Lapatinib-Induced Hepatotoxicity.

Degree: PhD, 2014, University of Washington

 Lapatinib was the first orally active dual tyrosine kinase inhibitor (TKI) of the epidermal growth factor receptor (EGFR, ErbB1) and human epidermal receptor 2 (HER2,… (more)

Subjects/Keywords: bioactivation; CYP3A4; CYP3A5; hepatotoxicity; lapatinib; metabolism; Pharmaceutical sciences; Chemistry; Toxicology; medicinal chemistry

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APA (6th Edition):

Wahlin, M. D. (2014). Defining the Relationship between the Bioactivation of Lapatinib by CYP3A and Lapatinib-Induced Hepatotoxicity. (Doctoral Dissertation). University of Washington. Retrieved from http://hdl.handle.net/1773/26061

Chicago Manual of Style (16th Edition):

Wahlin, Michelle Diane. “Defining the Relationship between the Bioactivation of Lapatinib by CYP3A and Lapatinib-Induced Hepatotoxicity.” 2014. Doctoral Dissertation, University of Washington. Accessed June 19, 2019. http://hdl.handle.net/1773/26061.

MLA Handbook (7th Edition):

Wahlin, Michelle Diane. “Defining the Relationship between the Bioactivation of Lapatinib by CYP3A and Lapatinib-Induced Hepatotoxicity.” 2014. Web. 19 Jun 2019.

Vancouver:

Wahlin MD. Defining the Relationship between the Bioactivation of Lapatinib by CYP3A and Lapatinib-Induced Hepatotoxicity. [Internet] [Doctoral dissertation]. University of Washington; 2014. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/1773/26061.

Council of Science Editors:

Wahlin MD. Defining the Relationship between the Bioactivation of Lapatinib by CYP3A and Lapatinib-Induced Hepatotoxicity. [Doctoral Dissertation]. University of Washington; 2014. Available from: http://hdl.handle.net/1773/26061

14. Michalsen, Bradley T. Synthesis and Bioactivation of Selective Estrogen Receptor Modulators (SERMs).

Degree: 2014, University of Illinois – Chicago

 The metabolism of estrogens and selective estrogen receptor modulators (SERMs) to electrophilic metabolites (bioactivation) has been postulated as a contributing factor in the initiation and/or… (more)

Subjects/Keywords: SERM estrogen quinone lasofoxifene bioactivation benzothiophene

bioactivation of EN to 4-OHEN-o-quinone ............... 8 Figure 4. Structures of LAS and E2… …bioactivation of E2 to 4-OHE2-o-quinone................. 9 Figure 5. Structure of bazedoxifene… …bioactivation of 3-methylindole, zafirlukast, and indomethacin… …11 Figure 6. Bioactivation of DMA to diquinone methide; 4'-fluoro substitution blocks… …90 Figure 38. Bioactivation of tamoxifen to o-quinone… 

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APA (6th Edition):

Michalsen, B. T. (2014). Synthesis and Bioactivation of Selective Estrogen Receptor Modulators (SERMs). (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/11227

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Michalsen, Bradley T. “Synthesis and Bioactivation of Selective Estrogen Receptor Modulators (SERMs).” 2014. Thesis, University of Illinois – Chicago. Accessed June 19, 2019. http://hdl.handle.net/10027/11227.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Michalsen, Bradley T. “Synthesis and Bioactivation of Selective Estrogen Receptor Modulators (SERMs).” 2014. Web. 19 Jun 2019.

Vancouver:

Michalsen BT. Synthesis and Bioactivation of Selective Estrogen Receptor Modulators (SERMs). [Internet] [Thesis]. University of Illinois – Chicago; 2014. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/10027/11227.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Michalsen BT. Synthesis and Bioactivation of Selective Estrogen Receptor Modulators (SERMs). [Thesis]. University of Illinois – Chicago; 2014. Available from: http://hdl.handle.net/10027/11227

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Duke University

15. FANG, MINGLIANG. Characterizing the Binding Potential, Activity, and Bioaccessibility of Peroxisome Proliferator Activated Receptor Gamma (PPARγ) Ligands in Indoor Dust .

Degree: 2015, Duke University

  Accumulating evidence is suggesting that exposure to some environmental contaminants may alter adipogenesis, resulting in accumulation of adipocytes, and often significant weight gain. Thus… (more)

Subjects/Keywords: Environmental health; Toxicology; Environmental science; Bioaccessibility; Bioactivation; Flame Retardants; House dust; Mixture Effect; Peroxisome Proliferator Activated Receptor Gamma

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APA (6th Edition):

FANG, M. (2015). Characterizing the Binding Potential, Activity, and Bioaccessibility of Peroxisome Proliferator Activated Receptor Gamma (PPARγ) Ligands in Indoor Dust . (Thesis). Duke University. Retrieved from http://hdl.handle.net/10161/9826

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

FANG, MINGLIANG. “Characterizing the Binding Potential, Activity, and Bioaccessibility of Peroxisome Proliferator Activated Receptor Gamma (PPARγ) Ligands in Indoor Dust .” 2015. Thesis, Duke University. Accessed June 19, 2019. http://hdl.handle.net/10161/9826.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

FANG, MINGLIANG. “Characterizing the Binding Potential, Activity, and Bioaccessibility of Peroxisome Proliferator Activated Receptor Gamma (PPARγ) Ligands in Indoor Dust .” 2015. Web. 19 Jun 2019.

Vancouver:

FANG M. Characterizing the Binding Potential, Activity, and Bioaccessibility of Peroxisome Proliferator Activated Receptor Gamma (PPARγ) Ligands in Indoor Dust . [Internet] [Thesis]. Duke University; 2015. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/10161/9826.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

FANG M. Characterizing the Binding Potential, Activity, and Bioaccessibility of Peroxisome Proliferator Activated Receptor Gamma (PPARγ) Ligands in Indoor Dust . [Thesis]. Duke University; 2015. Available from: http://hdl.handle.net/10161/9826

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Virginia Tech

16. Isin, Emre Mehmet. Studies on the Synthesis and Rearrangement of Indazolylpyridinium Derivatives Precursors to Potential Neuroprotective Prodrugs Bearing a 1,2,3,6-Tetrahydropyridinyl Carrier.

Degree: PhD, Chemistry, 2004, Virginia Tech

  The neuronal nitric oxide synthase (nNOS) inhibitor 7-nitroindazole (7-NI) protects against the neurotoxicity of MPTP in a mouse model of neurodegeneration. Since 7-NI also… (more)

Subjects/Keywords: Regiospecific synthesis; Monoamine oxidase; Bioactivation; Docking; Neuroprotection; Rearrangement

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APA (6th Edition):

Isin, E. M. (2004). Studies on the Synthesis and Rearrangement of Indazolylpyridinium Derivatives Precursors to Potential Neuroprotective Prodrugs Bearing a 1,2,3,6-Tetrahydropyridinyl Carrier. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/27363

Chicago Manual of Style (16th Edition):

Isin, Emre Mehmet. “Studies on the Synthesis and Rearrangement of Indazolylpyridinium Derivatives Precursors to Potential Neuroprotective Prodrugs Bearing a 1,2,3,6-Tetrahydropyridinyl Carrier.” 2004. Doctoral Dissertation, Virginia Tech. Accessed June 19, 2019. http://hdl.handle.net/10919/27363.

MLA Handbook (7th Edition):

Isin, Emre Mehmet. “Studies on the Synthesis and Rearrangement of Indazolylpyridinium Derivatives Precursors to Potential Neuroprotective Prodrugs Bearing a 1,2,3,6-Tetrahydropyridinyl Carrier.” 2004. Web. 19 Jun 2019.

Vancouver:

Isin EM. Studies on the Synthesis and Rearrangement of Indazolylpyridinium Derivatives Precursors to Potential Neuroprotective Prodrugs Bearing a 1,2,3,6-Tetrahydropyridinyl Carrier. [Internet] [Doctoral dissertation]. Virginia Tech; 2004. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/10919/27363.

Council of Science Editors:

Isin EM. Studies on the Synthesis and Rearrangement of Indazolylpyridinium Derivatives Precursors to Potential Neuroprotective Prodrugs Bearing a 1,2,3,6-Tetrahydropyridinyl Carrier. [Doctoral Dissertation]. Virginia Tech; 2004. Available from: http://hdl.handle.net/10919/27363


Virginia Tech

17. Liu, Xin. In vitro and in vivo studies on the biotransformation of β-nicotyrine, a minor tobacco alkaloid.

Degree: PhD, Chemistry, 1995, Virginia Tech

  ð ±-Nicotyrine is a minor tobacco alkaloid found in both tobacco plants and tobacco smoke. Preliminary studies have shown that ð ±-nicotyrine is pneumotoxic… (more)

Subjects/Keywords: metabolic bioactivation pathway - nicotine; LD5655.V856 1995.L583

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APA (6th Edition):

Liu, X. (1995). In vitro and in vivo studies on the biotransformation of β-nicotyrine, a minor tobacco alkaloid. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/39263

Chicago Manual of Style (16th Edition):

Liu, Xin. “In vitro and in vivo studies on the biotransformation of β-nicotyrine, a minor tobacco alkaloid.” 1995. Doctoral Dissertation, Virginia Tech. Accessed June 19, 2019. http://hdl.handle.net/10919/39263.

MLA Handbook (7th Edition):

Liu, Xin. “In vitro and in vivo studies on the biotransformation of β-nicotyrine, a minor tobacco alkaloid.” 1995. Web. 19 Jun 2019.

Vancouver:

Liu X. In vitro and in vivo studies on the biotransformation of β-nicotyrine, a minor tobacco alkaloid. [Internet] [Doctoral dissertation]. Virginia Tech; 1995. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/10919/39263.

Council of Science Editors:

Liu X. In vitro and in vivo studies on the biotransformation of β-nicotyrine, a minor tobacco alkaloid. [Doctoral Dissertation]. Virginia Tech; 1995. Available from: http://hdl.handle.net/10919/39263

18. PANG YI YUN. Toxicology and Pharmacology Investigation of 2-Phenylaminophenylacetic Acid Derived NSAIDs: Implication of Chemical Structure on Biological Outcomes.

Degree: 2014, National University of Singapore

Subjects/Keywords: 2-phenylaminophenylacetic acid; structure-toxicity-relationship; drug metabolism; bioactivation

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APA (6th Edition):

YUN, P. Y. (2014). Toxicology and Pharmacology Investigation of 2-Phenylaminophenylacetic Acid Derived NSAIDs: Implication of Chemical Structure on Biological Outcomes. (Thesis). National University of Singapore. Retrieved from http://scholarbank.nus.edu.sg/handle/10635/77758

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

YUN, PANG YI. “Toxicology and Pharmacology Investigation of 2-Phenylaminophenylacetic Acid Derived NSAIDs: Implication of Chemical Structure on Biological Outcomes.” 2014. Thesis, National University of Singapore. Accessed June 19, 2019. http://scholarbank.nus.edu.sg/handle/10635/77758.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

YUN, PANG YI. “Toxicology and Pharmacology Investigation of 2-Phenylaminophenylacetic Acid Derived NSAIDs: Implication of Chemical Structure on Biological Outcomes.” 2014. Web. 19 Jun 2019.

Vancouver:

YUN PY. Toxicology and Pharmacology Investigation of 2-Phenylaminophenylacetic Acid Derived NSAIDs: Implication of Chemical Structure on Biological Outcomes. [Internet] [Thesis]. National University of Singapore; 2014. [cited 2019 Jun 19]. Available from: http://scholarbank.nus.edu.sg/handle/10635/77758.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

YUN PY. Toxicology and Pharmacology Investigation of 2-Phenylaminophenylacetic Acid Derived NSAIDs: Implication of Chemical Structure on Biological Outcomes. [Thesis]. National University of Singapore; 2014. Available from: http://scholarbank.nus.edu.sg/handle/10635/77758

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


University of Saskatchewan

19. Asiamah, Isaac. Synthesis of nordihydroguaiaretic acid (NDGA) analogues and their oxidative metabolism.

Degree: 2015, University of Saskatchewan

 Nordihydroguaiaretic acid (NDGA), is a naturally-occurring lignan isolated from the creosote bush (Larrea tridentata). The aqueous extract of this shrub, commonly referred to as Chaparral… (more)

Subjects/Keywords: nordihydroguaiaretic aci; lignans; dibenzocyclooctadiene; autoxidation; cyclization; bioactivation; reactive metabolites; glutathione adducts; liquid chromatography–tandem mass spectrometry (LC–MS/MS); multiple reactions monitoring (MRM); neutral loss (NL); precursor ion (PI).

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APA (6th Edition):

Asiamah, I. (2015). Synthesis of nordihydroguaiaretic acid (NDGA) analogues and their oxidative metabolism. (Thesis). University of Saskatchewan. Retrieved from http://hdl.handle.net/10388/ETD-2015-06-1915

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Asiamah, Isaac. “Synthesis of nordihydroguaiaretic acid (NDGA) analogues and their oxidative metabolism.” 2015. Thesis, University of Saskatchewan. Accessed June 19, 2019. http://hdl.handle.net/10388/ETD-2015-06-1915.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Asiamah, Isaac. “Synthesis of nordihydroguaiaretic acid (NDGA) analogues and their oxidative metabolism.” 2015. Web. 19 Jun 2019.

Vancouver:

Asiamah I. Synthesis of nordihydroguaiaretic acid (NDGA) analogues and their oxidative metabolism. [Internet] [Thesis]. University of Saskatchewan; 2015. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/10388/ETD-2015-06-1915.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Asiamah I. Synthesis of nordihydroguaiaretic acid (NDGA) analogues and their oxidative metabolism. [Thesis]. University of Saskatchewan; 2015. Available from: http://hdl.handle.net/10388/ETD-2015-06-1915

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


University of Saskatchewan

20. Billinsky, Jennifer Lynn. Oxidative metabolism and cytochrome P450 enzyme inhibition potential of creosote bush and flaxseed lignans.

Degree: 2009, University of Saskatchewan

 The rising use of natural products creates an imperative need for an enhanced awareness of the safety of current and new products making their way… (more)

Subjects/Keywords: Secoisolariciresinol; Nordihydroguaiaretic acid; Flaxseed; quinone; Creosote bush; Anhydrosecoisolariciresinol; Enterolactone; Enterodiol; Dibenzocyclooctadiene; Cytochrome P450; bioactivation; inhibition; reactive intermediate; lignan; hepatotoxicity; autoxidation; Glutathione adduct

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APA (6th Edition):

Billinsky, J. L. (2009). Oxidative metabolism and cytochrome P450 enzyme inhibition potential of creosote bush and flaxseed lignans. (Thesis). University of Saskatchewan. Retrieved from http://hdl.handle.net/10388/etd-09212009-165345

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Billinsky, Jennifer Lynn. “Oxidative metabolism and cytochrome P450 enzyme inhibition potential of creosote bush and flaxseed lignans.” 2009. Thesis, University of Saskatchewan. Accessed June 19, 2019. http://hdl.handle.net/10388/etd-09212009-165345.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Billinsky, Jennifer Lynn. “Oxidative metabolism and cytochrome P450 enzyme inhibition potential of creosote bush and flaxseed lignans.” 2009. Web. 19 Jun 2019.

Vancouver:

Billinsky JL. Oxidative metabolism and cytochrome P450 enzyme inhibition potential of creosote bush and flaxseed lignans. [Internet] [Thesis]. University of Saskatchewan; 2009. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/10388/etd-09212009-165345.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Billinsky JL. Oxidative metabolism and cytochrome P450 enzyme inhibition potential of creosote bush and flaxseed lignans. [Thesis]. University of Saskatchewan; 2009. Available from: http://hdl.handle.net/10388/etd-09212009-165345

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Vrije Universiteit Amsterdam

21. Lipzig, M.M.H. van. The estrogen receptor, environmental estrogens and the role of cytochrome P450 in bioactivation .

Degree: 2011, Vrije Universiteit Amsterdam

Subjects/Keywords: estrogen receptor; environmental estrogens; xenoestrogen; bioactivation; biotransformation; cytochrome P450; metabolites

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APA (6th Edition):

Lipzig, M. M. H. v. (2011). The estrogen receptor, environmental estrogens and the role of cytochrome P450 in bioactivation . (Doctoral Dissertation). Vrije Universiteit Amsterdam. Retrieved from http://hdl.handle.net/1871/19013

Chicago Manual of Style (16th Edition):

Lipzig, M M H van. “The estrogen receptor, environmental estrogens and the role of cytochrome P450 in bioactivation .” 2011. Doctoral Dissertation, Vrije Universiteit Amsterdam. Accessed June 19, 2019. http://hdl.handle.net/1871/19013.

MLA Handbook (7th Edition):

Lipzig, M M H van. “The estrogen receptor, environmental estrogens and the role of cytochrome P450 in bioactivation .” 2011. Web. 19 Jun 2019.

Vancouver:

Lipzig MMHv. The estrogen receptor, environmental estrogens and the role of cytochrome P450 in bioactivation . [Internet] [Doctoral dissertation]. Vrije Universiteit Amsterdam; 2011. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/1871/19013.

Council of Science Editors:

Lipzig MMHv. The estrogen receptor, environmental estrogens and the role of cytochrome P450 in bioactivation . [Doctoral Dissertation]. Vrije Universiteit Amsterdam; 2011. Available from: http://hdl.handle.net/1871/19013


University of Gothenburg / Göteborgs Universitet

22. Belogorcev Niklasson, Ida. Epoxides as Contact Allergens - Formation, Sensitising Potency and Structure-Activity Relationships.

Degree: 2013, University of Gothenburg / Göteborgs Universitet

 Chemicals in our environment with which we have repeated skin contact can cause skin sensitisation (contact allergy). To trigger an immune response a compound (hapten)… (more)

Subjects/Keywords: Allergic contact dermatitis; Autoxidation; Bioactivation; Cinnamic alcohol; Diglycidyl ether of bisphenol A (DGEBA); Epoxide; Epoxy resin; Local lymph node assay; Polymerisation; Peptide reactivity; Prehapten; Prohapten; Sensitisation; Skin; Structure-Activity Relationship; Thermogravimetric Analysis

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APA (6th Edition):

Belogorcev Niklasson, I. (2013). Epoxides as Contact Allergens - Formation, Sensitising Potency and Structure-Activity Relationships. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/33972

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Belogorcev Niklasson, Ida. “Epoxides as Contact Allergens - Formation, Sensitising Potency and Structure-Activity Relationships.” 2013. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed June 19, 2019. http://hdl.handle.net/2077/33972.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Belogorcev Niklasson, Ida. “Epoxides as Contact Allergens - Formation, Sensitising Potency and Structure-Activity Relationships.” 2013. Web. 19 Jun 2019.

Vancouver:

Belogorcev Niklasson I. Epoxides as Contact Allergens - Formation, Sensitising Potency and Structure-Activity Relationships. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 2013. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/2077/33972.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Belogorcev Niklasson I. Epoxides as Contact Allergens - Formation, Sensitising Potency and Structure-Activity Relationships. [Thesis]. University of Gothenburg / Göteborgs Universitet; 2013. Available from: http://hdl.handle.net/2077/33972

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Vrije Universiteit Amsterdam

23. Damsten, M. Bioactivation of Drugs by Cytochromes P450 : New Tools and Concepts for the Characterization of Reactive Metabolites of Drugs .

Degree: 2009, Vrije Universiteit Amsterdam

Subjects/Keywords: Bioactivation of drugs by Cytochromes P450. New tools and concepts for the characterization of reactive drug metabolites; Drugs; Cytochrome P450

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APA (6th Edition):

Damsten, M. (2009). Bioactivation of Drugs by Cytochromes P450 : New Tools and Concepts for the Characterization of Reactive Metabolites of Drugs . (Doctoral Dissertation). Vrije Universiteit Amsterdam. Retrieved from http://hdl.handle.net/1871/15276

Chicago Manual of Style (16th Edition):

Damsten, M. “Bioactivation of Drugs by Cytochromes P450 : New Tools and Concepts for the Characterization of Reactive Metabolites of Drugs .” 2009. Doctoral Dissertation, Vrije Universiteit Amsterdam. Accessed June 19, 2019. http://hdl.handle.net/1871/15276.

MLA Handbook (7th Edition):

Damsten, M. “Bioactivation of Drugs by Cytochromes P450 : New Tools and Concepts for the Characterization of Reactive Metabolites of Drugs .” 2009. Web. 19 Jun 2019.

Vancouver:

Damsten M. Bioactivation of Drugs by Cytochromes P450 : New Tools and Concepts for the Characterization of Reactive Metabolites of Drugs . [Internet] [Doctoral dissertation]. Vrije Universiteit Amsterdam; 2009. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/1871/15276.

Council of Science Editors:

Damsten M. Bioactivation of Drugs by Cytochromes P450 : New Tools and Concepts for the Characterization of Reactive Metabolites of Drugs . [Doctoral Dissertation]. Vrije Universiteit Amsterdam; 2009. Available from: http://hdl.handle.net/1871/15276


University of Florida

24. Grundmann, Oliver. Anxiolytic Activity of Apocynum venetum L. and Its Proposed Mechanisms of Action.

Degree: PhD, Pharmaceutical Sciences - Pharmacy, 2007, University of Florida

 Anxiety affects one-eighth of the total population world-wide and has become an important area of research interest in psychopharmacology during this decade. Current treatment options… (more)

Subjects/Keywords: Antianxiety agents; Antioxidants; Anxiety; Anxiety disorders; Dosage; Dose response; Flavonoids; Flavonols; Metabolites; Receptors; anxiolytic, apocynum, bioactivation, bioguided, epm, flavonoid, gaba

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APA (6th Edition):

Grundmann, O. (2007). Anxiolytic Activity of Apocynum venetum L. and Its Proposed Mechanisms of Action. (Doctoral Dissertation). University of Florida. Retrieved from http://ufdc.ufl.edu/UFE0021588

Chicago Manual of Style (16th Edition):

Grundmann, Oliver. “Anxiolytic Activity of Apocynum venetum L. and Its Proposed Mechanisms of Action.” 2007. Doctoral Dissertation, University of Florida. Accessed June 19, 2019. http://ufdc.ufl.edu/UFE0021588.

MLA Handbook (7th Edition):

Grundmann, Oliver. “Anxiolytic Activity of Apocynum venetum L. and Its Proposed Mechanisms of Action.” 2007. Web. 19 Jun 2019.

Vancouver:

Grundmann O. Anxiolytic Activity of Apocynum venetum L. and Its Proposed Mechanisms of Action. [Internet] [Doctoral dissertation]. University of Florida; 2007. [cited 2019 Jun 19]. Available from: http://ufdc.ufl.edu/UFE0021588.

Council of Science Editors:

Grundmann O. Anxiolytic Activity of Apocynum venetum L. and Its Proposed Mechanisms of Action. [Doctoral Dissertation]. University of Florida; 2007. Available from: http://ufdc.ufl.edu/UFE0021588

25. Maloney, Katherine Ann. Synthesis of analogues of nordihydroguaiaretic acid and their oxidative metabolism.

Degree: 2010, University of Saskatchewan

 In order to investigate the structural features responsible for the cytotoxicity of the naturally occurring lignan nordihydroguaiaretic acid, the synthesis of four structural analogues of… (more)

Subjects/Keywords: cytochrome P450; bioactivation; reactive intermediate; lignan; anhydrosecoisolariciresinol; quinone; nordihydroguaiaretic acid; stobbe condensation; glutathione adduct

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APA (6th Edition):

Maloney, K. A. (2010). Synthesis of analogues of nordihydroguaiaretic acid and their oxidative metabolism. (Thesis). University of Saskatchewan. Retrieved from http://hdl.handle.net/10388/etd-05192010-134624

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Maloney, Katherine Ann. “Synthesis of analogues of nordihydroguaiaretic acid and their oxidative metabolism.” 2010. Thesis, University of Saskatchewan. Accessed June 19, 2019. http://hdl.handle.net/10388/etd-05192010-134624.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Maloney, Katherine Ann. “Synthesis of analogues of nordihydroguaiaretic acid and their oxidative metabolism.” 2010. Web. 19 Jun 2019.

Vancouver:

Maloney KA. Synthesis of analogues of nordihydroguaiaretic acid and their oxidative metabolism. [Internet] [Thesis]. University of Saskatchewan; 2010. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/10388/etd-05192010-134624.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Maloney KA. Synthesis of analogues of nordihydroguaiaretic acid and their oxidative metabolism. [Thesis]. University of Saskatchewan; 2010. Available from: http://hdl.handle.net/10388/etd-05192010-134624

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

26. Tervahauta, Tuomas. Non-cell-based in vitro methods in the study of prodrug absorption and metabolism.

Degree: Farmaceutiska fakulteten, 2015, University of Helsinki

Prodrugs are pharmacologically inactive molecules which undergo metabolic bioactivation in vivo to form pharmaceutically active agents. Prodrugs have been designed to improve so called drug-like… (more)

Subjects/Keywords: PAMPA; prodrug; bioactivation; absorption; metabolism; S9 fractions; LC-MS/MS; aihiolääke; bioaktivaatio; imeytyminen; metabolia; S9-fraktio; Biofarmaci; Biopharmacy; Biofarmasia; PAMPA; prodrug; bioactivation; absorption; metabolism; S9 fractions; LC-MS/MS; aihiolääke; bioaktivaatio; imeytyminen; metabolia; S9-fraktio

…Ishizuka et al. 2012). The enzyme responsible for bioactivation in plasma was recognized to… …fraction as discussed later. The enzyme responsible for metabolic tissue bioactivation was… …olmesartan medoxomil (Figure 8). Bioactivation was observed to be higher in cytosolic… …similar bioactivation rates than human intestinal cytosols (Figure 8). The… …bioactivation was also observed in rat intestinal fractions, but not in dog. The bioactivation in… 

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APA (6th Edition):

Tervahauta, T. (2015). Non-cell-based in vitro methods in the study of prodrug absorption and metabolism. (Masters Thesis). University of Helsinki. Retrieved from http://hdl.handle.net/10138/153220

Chicago Manual of Style (16th Edition):

Tervahauta, Tuomas. “Non-cell-based in vitro methods in the study of prodrug absorption and metabolism.” 2015. Masters Thesis, University of Helsinki. Accessed June 19, 2019. http://hdl.handle.net/10138/153220.

MLA Handbook (7th Edition):

Tervahauta, Tuomas. “Non-cell-based in vitro methods in the study of prodrug absorption and metabolism.” 2015. Web. 19 Jun 2019.

Vancouver:

Tervahauta T. Non-cell-based in vitro methods in the study of prodrug absorption and metabolism. [Internet] [Masters thesis]. University of Helsinki; 2015. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/10138/153220.

Council of Science Editors:

Tervahauta T. Non-cell-based in vitro methods in the study of prodrug absorption and metabolism. [Masters Thesis]. University of Helsinki; 2015. Available from: http://hdl.handle.net/10138/153220

27. Metushi, Imir G. Investigation of the Mechanism of Idiosyncratic Drug-induced Liver Injury.

Degree: 2014, University of Toronto

Idiosyncratic drug reactions represent a special problem because of their unpredictable nature, and idiosyncratic drug-induced liver injury (IDILI) is a major reason for drug withdrawal.… (more)

Subjects/Keywords: Idiosyncratic drug reactions; reactive metabolites; immunotoxicology; immune mediated; tolerance; bioactivation; covalent binding; autoimmunity; liver injury; hepatotoxicity; liver failure; animal model; autoantibodies; anti-drug antibodies; adaptation; T helper 17 cells; natural killer cells; interleukin 10; 0419; 0982

…AcHz ratio in mice and rats, page 97 Figure 22: Proposed bioactivation pathway of INH, page… …believed to be due to bioactivation of acetylhydrazine (AcHz), a metabolite of INH… …likely immune-mediated.10 However, because the liver is commonly involved in bioactivation of… 

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Metushi, I. G. (2014). Investigation of the Mechanism of Idiosyncratic Drug-induced Liver Injury. (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/69061

Chicago Manual of Style (16th Edition):

Metushi, Imir G. “Investigation of the Mechanism of Idiosyncratic Drug-induced Liver Injury.” 2014. Doctoral Dissertation, University of Toronto. Accessed June 19, 2019. http://hdl.handle.net/1807/69061.

MLA Handbook (7th Edition):

Metushi, Imir G. “Investigation of the Mechanism of Idiosyncratic Drug-induced Liver Injury.” 2014. Web. 19 Jun 2019.

Vancouver:

Metushi IG. Investigation of the Mechanism of Idiosyncratic Drug-induced Liver Injury. [Internet] [Doctoral dissertation]. University of Toronto; 2014. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/1807/69061.

Council of Science Editors:

Metushi IG. Investigation of the Mechanism of Idiosyncratic Drug-induced Liver Injury. [Doctoral Dissertation]. University of Toronto; 2014. Available from: http://hdl.handle.net/1807/69061

28. Lee, Crystal J. J. Molecular Mechanisms and Determinants of Species Sensitivity in Thalidomide Teratogenesis.

Degree: 2012, University of Toronto

The expanding therapeutic use of thalidomide (TD) remains limited by its species-specific teratogenicity in humans and rabbits, but not rodents. The R and S isomers… (more)

Subjects/Keywords: thalidomide; birth defects (teratogenesis); hydrolysis products; rabbit embryo culture; mouse embryo culture; limb embryopathies; fluorothalidomide; thalidomide analogs; reactive oxygen species; free radical reactive intermediates; oxidative DNA damage; 8-oxoguanine glycosylase 1 (Ogg1); DNA repair; prostaglandin H synthase (PHS); xenobiotic bioactivation; 0383; 0419

…teratogenesis: Bioactivation by CYPs (cytochromes P450)… …96 - 97 Table 9 Mechanisms implicated in TD teratogenesis: Bioactivation by PHSs and LPOs… …Teratogenesis Bioactivation of xenobiotics by embryonic enzymes such as CYPs, prostaglandin H… …development (Wells et al. 1997; Wells et al. 2009b). A classic XENOBIOTIC BIOACTIVATION… …formed upon CYP1A1catalyzed bioactivation of B[a]P (Wells et al. 1997)… 

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APA (6th Edition):

Lee, C. J. J. (2012). Molecular Mechanisms and Determinants of Species Sensitivity in Thalidomide Teratogenesis. (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/36210

Chicago Manual of Style (16th Edition):

Lee, Crystal J J. “Molecular Mechanisms and Determinants of Species Sensitivity in Thalidomide Teratogenesis.” 2012. Doctoral Dissertation, University of Toronto. Accessed June 19, 2019. http://hdl.handle.net/1807/36210.

MLA Handbook (7th Edition):

Lee, Crystal J J. “Molecular Mechanisms and Determinants of Species Sensitivity in Thalidomide Teratogenesis.” 2012. Web. 19 Jun 2019.

Vancouver:

Lee CJJ. Molecular Mechanisms and Determinants of Species Sensitivity in Thalidomide Teratogenesis. [Internet] [Doctoral dissertation]. University of Toronto; 2012. [cited 2019 Jun 19]. Available from: http://hdl.handle.net/1807/36210.

Council of Science Editors:

Lee CJJ. Molecular Mechanisms and Determinants of Species Sensitivity in Thalidomide Teratogenesis. [Doctoral Dissertation]. University of Toronto; 2012. Available from: http://hdl.handle.net/1807/36210

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