subject:(antidepressants)

University of Florida

1. Hakam, Abeer Essam M. Antidepressant Medications and Their Effect on Periodontal Health and Stability- A Clinical Retrospective Study.

Degree: MS, Dental Sciences - Dentistry, 2020, University of Florida

URL: https://ufdc.ufl.edu/UFE0056563

Background: Evidence in the literature are conflicting in regard to depression, antidepressants (AD) and their effect on periodontal health. Advisors/Committee Members: Chang,Jia (committee chair), Rodrigues Duarte,Wagner (committee member), Mendes Duarte Reis,Poliana (committee member).

Subjects/Keywords: antidepressants – periodontitis

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APA (6^th Edition):

Hakam, A. E. M. (2020). Antidepressant Medications and Their Effect on Periodontal Health and Stability- A Clinical Retrospective Study. (Masters Thesis). University of Florida. Retrieved from https://ufdc.ufl.edu/UFE0056563

Chicago Manual of Style (16^th Edition):

Hakam, Abeer Essam M. “Antidepressant Medications and Their Effect on Periodontal Health and Stability- A Clinical Retrospective Study.” 2020. Masters Thesis, University of Florida. Accessed February 27, 2021. https://ufdc.ufl.edu/UFE0056563.

MLA Handbook (7^th Edition):

Hakam, Abeer Essam M. “Antidepressant Medications and Their Effect on Periodontal Health and Stability- A Clinical Retrospective Study.” 2020. Web. 27 Feb 2021.

Vancouver:

Hakam AEM. Antidepressant Medications and Their Effect on Periodontal Health and Stability- A Clinical Retrospective Study. [Internet] [Masters thesis]. University of Florida; 2020. [cited 2021 Feb 27]. Available from: https://ufdc.ufl.edu/UFE0056563.

Council of Science Editors:

Hakam AEM. Antidepressant Medications and Their Effect on Periodontal Health and Stability- A Clinical Retrospective Study. [Masters Thesis]. University of Florida; 2020. Available from: https://ufdc.ufl.edu/UFE0056563

Rhodes University

2. Skene, Debra Jean. The evaluation of melatonin as a possible antidepressive.

Degree: Faculty of Pharmacy, Pharmacy, 1980, Rhodes University

URL: http://hdl.handle.net/10962/d1001465

► Melatonin, a hormone of the pineal gland, was evaluated in a variety of animal models of depression. Measurements of the frog righting reflex and rat… (more)

Subjects/Keywords: Melatonin; Antidepressants

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APA (6^th Edition):

Skene, D. J. (1980). The evaluation of melatonin as a possible antidepressive. (Thesis). Rhodes University. Retrieved from http://hdl.handle.net/10962/d1001465

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Skene, Debra Jean. “The evaluation of melatonin as a possible antidepressive.” 1980. Thesis, Rhodes University. Accessed February 27, 2021. http://hdl.handle.net/10962/d1001465.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Skene, Debra Jean. “The evaluation of melatonin as a possible antidepressive.” 1980. Web. 27 Feb 2021.

Vancouver:

Skene DJ. The evaluation of melatonin as a possible antidepressive. [Internet] [Thesis]. Rhodes University; 1980. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10962/d1001465.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Skene DJ. The evaluation of melatonin as a possible antidepressive. [Thesis]. Rhodes University; 1980. Available from: http://hdl.handle.net/10962/d1001465

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Alberta

3. Aspeslet, Launa J. Chirality and metabolism: studies on the antidepressants rac-tranylcypromine and rac-fluoxetine.

Degree: PhD, Faculty of Medicine Faculty of Pharmacy and Pharmaceutical Sciences, 1994, University of Alberta

URL: https://era.library.ualberta.ca/files/qv33s018k

Subjects/Keywords: Antidepressants – Metabolism.

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APA (6^th Edition):

Aspeslet, L. J. (1994). Chirality and metabolism: studies on the antidepressants rac-tranylcypromine and rac-fluoxetine. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/qv33s018k

Chicago Manual of Style (16^th Edition):

Aspeslet, Launa J. “Chirality and metabolism: studies on the antidepressants rac-tranylcypromine and rac-fluoxetine.” 1994. Doctoral Dissertation, University of Alberta. Accessed February 27, 2021. https://era.library.ualberta.ca/files/qv33s018k.

MLA Handbook (7^th Edition):

Aspeslet, Launa J. “Chirality and metabolism: studies on the antidepressants rac-tranylcypromine and rac-fluoxetine.” 1994. Web. 27 Feb 2021.

Vancouver:

Aspeslet LJ. Chirality and metabolism: studies on the antidepressants rac-tranylcypromine and rac-fluoxetine. [Internet] [Doctoral dissertation]. University of Alberta; 1994. [cited 2021 Feb 27]. Available from: https://era.library.ualberta.ca/files/qv33s018k.

Council of Science Editors:

Aspeslet LJ. Chirality and metabolism: studies on the antidepressants rac-tranylcypromine and rac-fluoxetine. [Doctoral Dissertation]. University of Alberta; 1994. Available from: https://era.library.ualberta.ca/files/qv33s018k

University of Alberta

4. Paetsch, Paul R. 2-phenylethylamine: possible role in antidepressant drug action.

Degree: PhD, Department of Medicine, 1992, University of Alberta

URL: https://era.library.ualberta.ca/files/5138jg73t

Subjects/Keywords: Antidepressants.; Phenethylamines.

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APA (6^th Edition):

Paetsch, P. R. (1992). 2-phenylethylamine: possible role in antidepressant drug action. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/5138jg73t

Chicago Manual of Style (16^th Edition):

Paetsch, Paul R. “2-phenylethylamine: possible role in antidepressant drug action.” 1992. Doctoral Dissertation, University of Alberta. Accessed February 27, 2021. https://era.library.ualberta.ca/files/5138jg73t.

MLA Handbook (7^th Edition):

Paetsch, Paul R. “2-phenylethylamine: possible role in antidepressant drug action.” 1992. Web. 27 Feb 2021.

Vancouver:

Paetsch PR. 2-phenylethylamine: possible role in antidepressant drug action. [Internet] [Doctoral dissertation]. University of Alberta; 1992. [cited 2021 Feb 27]. Available from: https://era.library.ualberta.ca/files/5138jg73t.

Council of Science Editors:

Paetsch PR. 2-phenylethylamine: possible role in antidepressant drug action. [Doctoral Dissertation]. University of Alberta; 1992. Available from: https://era.library.ualberta.ca/files/5138jg73t

University of Alberta

5. Dhami, Kamaldeep S. The effects of antidepressants on the phenotype of activated microglia and ischemia-injured cortical neurons.

Degree: PhD, Centre for Neuroscience, 2013, University of Alberta

URL: https://era.library.ualberta.ca/files/5x21tf82p

► Depression is one of the most common disorders appearing following a stroke and is also a major factor limiting recovery and rehabilitation in stroke patients.… (more)

▼ Depression is one of the most common disorders appearing following a stroke and is also a major factor limiting recovery and rehabilitation in stroke patients. Several antidepressants have shown to have anti-inflammatory properties within the central nervous system (CNS). The major source of pro-inflammatory factors within the CNS is from activated microglia, the innate immune cells of the CNS. Antidepressants have been shown to promote midbrain and hippocampal neuronal survival following an ischemic insult and these effects are mediated through the anti-inflammatory effects on microglia, but the effects on cortical neuronal survival after this insult have yet to be investigated. The present study aimed to test and compare antidepressants from three distinct classes (tricylics, monoamine oxidase inhibitors, and selective serotonin reuptake inhibitors [SSRIs]) on the release of inflammatory factors and amino acids from activated microglia and to determine whether altering this release could affect cortical neuronal viability after an ischemic insult. Primary microglia were treated with 1 μg/ml LPS and/or 10 μM antidepressants, and the various factors released into the medium were assayed. Co-cultures consisting of microglia and primary cortical neurons were used to assess the effects of antidepressant-treated activated microglia on the viability of ischemia-injured neurons. Of the antidepressants tested, most decreased the release of the pro-inflammatory factors nitric oxide, tumor necrosis factor-alpha, and interleukin 1- beta from activated microglia. Fluoxetine and citalopram, the SSRIs, also decreased the release of the amino acids glutamate and D-serine from LPS-activated microglia. Injured cortical neurons co-cultured with LPS-activated microglia pre-treated with fluoxetine and citalopram showed greater survival compared to injured neurons co-cultured with untreated activated microglia. Studies using NMDA receptor antagonists demonstrated that the release of glutamate and D-serine from microglia was a principal factor mediating cortical neuronal survival. In addition, we found that one possible mechanism behind the attenuation of microglial glutamate and D-serine release following fluoxetine treatment is through the induction of microglial apoptosis. Our results demonstrated for the first time that fluoxetine and citalopram decrease the release of glutamate and D- serine from LPS-activated microglia and this increases the survival of injured cortical neurons after co-culture. Fluoxetine was also shown to induce the apoptotic death of microglia.

Subjects/Keywords: Inflammation; Microglia; Excitotoxicity; Ischemia; Antidepressants

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APA (6^th Edition):

Dhami, K. S. (2013). The effects of antidepressants on the phenotype of activated microglia and ischemia-injured cortical neurons. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/5x21tf82p

Chicago Manual of Style (16^th Edition):

Dhami, Kamaldeep S. “The effects of antidepressants on the phenotype of activated microglia and ischemia-injured cortical neurons.” 2013. Doctoral Dissertation, University of Alberta. Accessed February 27, 2021. https://era.library.ualberta.ca/files/5x21tf82p.

MLA Handbook (7^th Edition):

Dhami, Kamaldeep S. “The effects of antidepressants on the phenotype of activated microglia and ischemia-injured cortical neurons.” 2013. Web. 27 Feb 2021.

Vancouver:

Dhami KS. The effects of antidepressants on the phenotype of activated microglia and ischemia-injured cortical neurons. [Internet] [Doctoral dissertation]. University of Alberta; 2013. [cited 2021 Feb 27]. Available from: https://era.library.ualberta.ca/files/5x21tf82p.

Council of Science Editors:

Dhami KS. The effects of antidepressants on the phenotype of activated microglia and ischemia-injured cortical neurons. [Doctoral Dissertation]. University of Alberta; 2013. Available from: https://era.library.ualberta.ca/files/5x21tf82p

Rhodes University

6. Steiner, Claire. An investigation into the possible neuroprotective role of antidepressant drugs.

Degree: MS, Faculty of Pharmacy, Pharmacy, 2002, Rhodes University

URL: http://hdl.handle.net/10962/d1003270

► Antidepressants are widely used in the treatment of depressive illnesses associated with neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease and Huntington’s disease. Neuroprotection in… (more)

▼ Antidepressants are widely used in the treatment of depressive illnesses associated with neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease and Huntington’s disease. Neuroprotection in such disorders is of vital importance in order to delay the progression of the primary disorder. The pathology of neurodegeneration is not fully understood. It is however widely accepted that oxidative stress and excitotoxicity play a major role. Brain tissue is rich in phospholipids, which are especially prone to oxidation due to the high level of oxygen utilization in the brain. In addition, the brain lacks defence mechanisms to protect it against the wrath of free radicals. Presently, there is a wide variety of antidepressant drugs available. These range from the original tricyclic antidepressants to the newer selective serotonin reuptake inhibitors. It is not known whether antidepressant drugs, old or new, offer neuroprotection or how the existing state and/or the progression of neurodegeneration, is influenced by these agents. The present study was undertaken to determine how nortriptyline, trimipramine and fluoxetine affect neurodegeneration. Initial in vitro and in vivo studies show that all three of the antidepressants (0-1mM) studied provide neuroprotection from quinolinic acid induced lipid peroxidation. A histological investigation supported these findings by showing that a marginal degree of neuroprotection is apparent when treating animals with antidepressants (10mg/kg) before and following quinolinic acid intrastriatal injection. Further studies were undertaken in an attempt to determine the mode of neuroprotective action of the agents studied. An in vitro study of superoxide anion induced lipid peroxidation indicates that these agents do not act as antioxidants. The influence of the antidepressants on tryptophan 2,3-dioxygenase activity was assessed, based on the understanding that inhibition of this enzyme results in increased levels of the known antioxidant indoleamine, melatonin. Nortriptyline hydrochloride is seen to inhibit tryptophan 2,3-dioxygenase activity and as such it is possible that this antidepressant can indirectly provide neuroprotection by increasing available melatonin. Electrochemical and UV/visible studies show that trimipramine maleate interacts with free iron (II) and iron (III) ions. Free metal ions can catalyse the formation of damaging free radicals. Through interaction with trimipramine maleate, these ions will be unavailable to the system and thus cannot contribute to oxidative stress. The findings of this study indicate that antidepressants may be able to provide neuroprotection to neuronal cells. The mode of such neuroprotective actions need to be further examined so that patients suffering from depression coexisting with neurodegenerative diseases can be safely and effectively treated. Advisors/Committee Members: Daya, Santy.

Subjects/Keywords: Antidepressants – Research

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APA (6^th Edition):

Steiner, C. (2002). An investigation into the possible neuroprotective role of antidepressant drugs. (Masters Thesis). Rhodes University. Retrieved from http://hdl.handle.net/10962/d1003270

Chicago Manual of Style (16^th Edition):

Steiner, Claire. “An investigation into the possible neuroprotective role of antidepressant drugs.” 2002. Masters Thesis, Rhodes University. Accessed February 27, 2021. http://hdl.handle.net/10962/d1003270.

MLA Handbook (7^th Edition):

Steiner, Claire. “An investigation into the possible neuroprotective role of antidepressant drugs.” 2002. Web. 27 Feb 2021.

Vancouver:

Steiner C. An investigation into the possible neuroprotective role of antidepressant drugs. [Internet] [Masters thesis]. Rhodes University; 2002. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10962/d1003270.

Council of Science Editors:

Steiner C. An investigation into the possible neuroprotective role of antidepressant drugs. [Masters Thesis]. Rhodes University; 2002. Available from: http://hdl.handle.net/10962/d1003270

King's College London (University of London)

7. Hodgson, Karen. Biomarkers of antidepressant treatment outcomes.

Degree: PhD, 2015, King's College London (University of London)

URL: http://kclpure.kcl.ac.uk/portal/en/theses/biomarkers-of-antidepressant-treatment-outcomes(dcd101e2-4f7b-423c-8354-29c3d827fd91).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.634169

► Whilst antidepressants are widely prescribed, there is a large degree of variation between patients in terms of treatment outcomes. Furthermore, the mechanisms by which these… (more)

▼ Whilst antidepressants are widely prescribed, there is a large degree of variation between patients in terms of treatment outcomes. Furthermore, the mechanisms by which these drugs exert their effects remain unclear. In this thesis, genetic biomarkers of antidepressant outcomes have been explored, in order to better understand the molecular mechanisms underpinning effective antidepressant treatment. The research presented here use data from the GENDEP project, which is a large pharmacogenetic study of depressed patients receiving antidepressant treatment. Firstly, the pharmacological underpinnings of antidepressant-associated side effects were used to categorise these side effects and conduct a candidate gene analysis. Whilst a significant association between variation within the HTR2C gene and serotonergic side effects was found, the observation was not replicated in a second sample. Secondly, the role of variability in drug metabolism rates in treatment outcomes was investigated. Examining genotypic information on the cytochrome P450 enzymes, no associations with treatment response, side effects or study discontinuation were observed. Furthermore, serum concentrations of antidepressant were unrelated to treatment response or overall burden of side effects, predicting only a minority of specific side effects. Thirdly, transcriptomic changes with drug administration were explored in relation to treatment efficacy. Two genes were identified where changes in expression levels were significantly associated with treatment response amongst patients taking nortriptyline. Furthermore, using a network-based approach, changes in gene expression across one module of coexpressed genes showed significant correlation with symptom improvement; this biological network generalised across different antidepressant medications. Finally, genomic and transcriptomic data were combined, in an examination of the genetic control of gene expression. This analysis then was used to gain an insight into the molecular processes that link genotype to phenotype. The evidence presented within this thesis, when considered in combination with existing literature, highlights that antidepressant efficacy is a complex trait, influenced by many genes of small effect. Nevertheless, by layering together different levels of information, we can begin to dissect the molecular mechanisms involved in antidepressant action.

Subjects/Keywords: 616.85; Pharmacogenetics; Antidepressants; Transcriptomics; Depression

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APA (6^th Edition):

Hodgson, K. (2015). Biomarkers of antidepressant treatment outcomes. (Doctoral Dissertation). King's College London (University of London). Retrieved from http://kclpure.kcl.ac.uk/portal/en/theses/biomarkers-of-antidepressant-treatment-outcomes(dcd101e2-4f7b-423c-8354-29c3d827fd91).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.634169

Chicago Manual of Style (16^th Edition):

Hodgson, Karen. “Biomarkers of antidepressant treatment outcomes.” 2015. Doctoral Dissertation, King's College London (University of London). Accessed February 27, 2021. http://kclpure.kcl.ac.uk/portal/en/theses/biomarkers-of-antidepressant-treatment-outcomes(dcd101e2-4f7b-423c-8354-29c3d827fd91).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.634169.

MLA Handbook (7^th Edition):

Hodgson, Karen. “Biomarkers of antidepressant treatment outcomes.” 2015. Web. 27 Feb 2021.

Vancouver:

Hodgson K. Biomarkers of antidepressant treatment outcomes. [Internet] [Doctoral dissertation]. King's College London (University of London); 2015. [cited 2021 Feb 27]. Available from: http://kclpure.kcl.ac.uk/portal/en/theses/biomarkers-of-antidepressant-treatment-outcomes(dcd101e2-4f7b-423c-8354-29c3d827fd91).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.634169.

Council of Science Editors:

Hodgson K. Biomarkers of antidepressant treatment outcomes. [Doctoral Dissertation]. King's College London (University of London); 2015. Available from: http://kclpure.kcl.ac.uk/portal/en/theses/biomarkers-of-antidepressant-treatment-outcomes(dcd101e2-4f7b-423c-8354-29c3d827fd91).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.634169

University of Melbourne

8. Galbally, Megan. A prospective longitudinal study of child development following in-utero exposure to antidepressant medication.

Degree: 2014, University of Melbourne

URL: http://hdl.handle.net/11343/51716

► Background: The recognition of the importance of treatment for depression in pregnancy to optimise both maternal and child outcomes parallels the increasing use of antidepressants… (more)

▼ Background: The recognition of the importance of treatment for depression in pregnancy to optimise both maternal and child outcomes parallels the increasing use of antidepressants in pregnancy across many countries in the world. However, there is also research to suggest that women are often reluctant to commence treatment or they abruptly cease antidepressant treatment on becoming pregnant due to concerns about long term safety of exposure for their unborn child. This thesis examines child developmental outcomes following in utero exposure to antidepressant medication using two data sets. These two data sets are distinct in methodology allowing a comparison of both methods and results when examining child outcomes following exposure in pregnancy. Methods: The first study is the Victorian Psychotropic Registry (VPR), a purpose designed, prospective, longitudinal study established by the candidate and where children have been followed from in utero to 5 years of age. The second study is the Longitudinal Study of Australian Children (LSAC), a large, normative, population based cohort across early childhood established by the Commonwealth Government of Australia. Both studies had an antidepressant exposed group of children and a control group and both studies had measures of maternal depression in pregnancy, postpartum and into childhood as well as measures of other exposures in pregnancy, such as alcohol and smoking. The VPR collected all data prospectively whereas the pregnancy measures for LSAC were retrospectively collected in the postpartum. The three areas of child development of focus in this thesis are: cognitive development, motor development and child adjustment and emotional development. Where possible, measures were chosen in LSAC, which closely matched those in age and domain to the VPR. Children were assessed at 4-7 years of age across the two studies. Results: This thesis found that in both data sets there was no evidence of an effect on cognitive development from antidepressant exposure in pregnancy. The results for both motor development and emotional development were more complex. For motor development there was a trend to lower scores in the VPR study on a specific neuropsychological measure of motor development: Movement ABC, without reaching a statistically significant difference but small effect sizes. There was no observational or task measures of motor development in LSAC. Both the VPR study and LSAC found a difference on a screening measure, Peds QL Physical Health Score, with exposed children having a lower score. However, when this was adjusted for the covariate of maternal depression this was no longer significant. Child adjustment and emotional development was examined in two areas. The first was internalizing and externalizing scores, within the VPR on the CBCL and within LSAC on SDQ, the second area was parenting and parent-child relational stress measured in VPR with PSI total stress score and within LSAC with the Parenting Efficacy Scale. VPR found there was no…

Subjects/Keywords: pregnancy; antidepressants; child development; depression

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APA (6^th Edition):

Galbally, M. (2014). A prospective longitudinal study of child development following in-utero exposure to antidepressant medication. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/51716

Chicago Manual of Style (16^th Edition):

Galbally, Megan. “A prospective longitudinal study of child development following in-utero exposure to antidepressant medication.” 2014. Doctoral Dissertation, University of Melbourne. Accessed February 27, 2021. http://hdl.handle.net/11343/51716.

MLA Handbook (7^th Edition):

Galbally, Megan. “A prospective longitudinal study of child development following in-utero exposure to antidepressant medication.” 2014. Web. 27 Feb 2021.

Vancouver:

Galbally M. A prospective longitudinal study of child development following in-utero exposure to antidepressant medication. [Internet] [Doctoral dissertation]. University of Melbourne; 2014. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/11343/51716.

Council of Science Editors:

Galbally M. A prospective longitudinal study of child development following in-utero exposure to antidepressant medication. [Doctoral Dissertation]. University of Melbourne; 2014. Available from: http://hdl.handle.net/11343/51716

Michigan State University

9. Vrbanac, John James. Neuropsychopharmacological investigations with 4H-3-methylcarboxamide-3,4-benzoxazine-2-one : demonstration of a novel spectrum of central activity.

Degree: MS, Department of Pharmacology, 1978, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:37698

Subjects/Keywords: Antidepressants; Neuropsychopharmacology

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APA (6^th Edition):

Vrbanac, J. J. (1978). Neuropsychopharmacological investigations with 4H-3-methylcarboxamide-3,4-benzoxazine-2-one : demonstration of a novel spectrum of central activity. (Masters Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:37698

Chicago Manual of Style (16^th Edition):

Vrbanac, John James. “Neuropsychopharmacological investigations with 4H-3-methylcarboxamide-3,4-benzoxazine-2-one : demonstration of a novel spectrum of central activity.” 1978. Masters Thesis, Michigan State University. Accessed February 27, 2021. http://etd.lib.msu.edu/islandora/object/etd:37698.

MLA Handbook (7^th Edition):

Vrbanac, John James. “Neuropsychopharmacological investigations with 4H-3-methylcarboxamide-3,4-benzoxazine-2-one : demonstration of a novel spectrum of central activity.” 1978. Web. 27 Feb 2021.

Vancouver:

Vrbanac JJ. Neuropsychopharmacological investigations with 4H-3-methylcarboxamide-3,4-benzoxazine-2-one : demonstration of a novel spectrum of central activity. [Internet] [Masters thesis]. Michigan State University; 1978. [cited 2021 Feb 27]. Available from: http://etd.lib.msu.edu/islandora/object/etd:37698.

Council of Science Editors:

Vrbanac JJ. Neuropsychopharmacological investigations with 4H-3-methylcarboxamide-3,4-benzoxazine-2-one : demonstration of a novel spectrum of central activity. [Masters Thesis]. Michigan State University; 1978. Available from: http://etd.lib.msu.edu/islandora/object/etd:37698

University of Arizona

10. Hintermeister, Nalukui Mwisiya. SYNTHESIS AND NMR STUDIES OF PERI-SUBSTITUTED PROMAZINE AND IMIPRAMINE ANALOGUES.

Degree: 1984, University of Arizona

URL: http://hdl.handle.net/10150/275000

Subjects/Keywords: Antidepressants.; Antidepressants – Spectra.; Imipramine.

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APA (6^th Edition):

Hintermeister, N. M. (1984). SYNTHESIS AND NMR STUDIES OF PERI-SUBSTITUTED PROMAZINE AND IMIPRAMINE ANALOGUES. (Masters Thesis). University of Arizona. Retrieved from http://hdl.handle.net/10150/275000

Chicago Manual of Style (16^th Edition):

Hintermeister, Nalukui Mwisiya. “SYNTHESIS AND NMR STUDIES OF PERI-SUBSTITUTED PROMAZINE AND IMIPRAMINE ANALOGUES. ” 1984. Masters Thesis, University of Arizona. Accessed February 27, 2021. http://hdl.handle.net/10150/275000.

MLA Handbook (7^th Edition):

Hintermeister, Nalukui Mwisiya. “SYNTHESIS AND NMR STUDIES OF PERI-SUBSTITUTED PROMAZINE AND IMIPRAMINE ANALOGUES. ” 1984. Web. 27 Feb 2021.

Vancouver:

Hintermeister NM. SYNTHESIS AND NMR STUDIES OF PERI-SUBSTITUTED PROMAZINE AND IMIPRAMINE ANALOGUES. [Internet] [Masters thesis]. University of Arizona; 1984. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10150/275000.

Council of Science Editors:

Hintermeister NM. SYNTHESIS AND NMR STUDIES OF PERI-SUBSTITUTED PROMAZINE AND IMIPRAMINE ANALOGUES. [Masters Thesis]. University of Arizona; 1984. Available from: http://hdl.handle.net/10150/275000

Queensland University of Technology

11. Sanjida, Saira. A retrospective case-control study on the prescribing practices of antidepressants administered to cancer patients and non-cancer patients in Australia.

Degree: 2016, Queensland University of Technology

URL: http://eprints.qut.edu.au/94240/

► Comorbidity of depression risks is common among cancer patients. The pharmacological treatment of depression is antidepressants. However, antidepressants may interact with anticancer drugs or cause… (more)

Subjects/Keywords: Antidepressants; Cancer; Prescription; Psychotropic; Non-cancer

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APA (6^th Edition):

Sanjida, S. (2016). A retrospective case-control study on the prescribing practices of antidepressants administered to cancer patients and non-cancer patients in Australia. (Thesis). Queensland University of Technology. Retrieved from http://eprints.qut.edu.au/94240/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sanjida, Saira. “A retrospective case-control study on the prescribing practices of antidepressants administered to cancer patients and non-cancer patients in Australia.” 2016. Thesis, Queensland University of Technology. Accessed February 27, 2021. http://eprints.qut.edu.au/94240/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sanjida, Saira. “A retrospective case-control study on the prescribing practices of antidepressants administered to cancer patients and non-cancer patients in Australia.” 2016. Web. 27 Feb 2021.

Vancouver:

Sanjida S. A retrospective case-control study on the prescribing practices of antidepressants administered to cancer patients and non-cancer patients in Australia. [Internet] [Thesis]. Queensland University of Technology; 2016. [cited 2021 Feb 27]. Available from: http://eprints.qut.edu.au/94240/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sanjida S. A retrospective case-control study on the prescribing practices of antidepressants administered to cancer patients and non-cancer patients in Australia. [Thesis]. Queensland University of Technology; 2016. Available from: http://eprints.qut.edu.au/94240/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

12. Carla Maria Maia Garcias. PREVALÊNCIA E FATORES ASSOCIADOS AO USO DE ANTIDEPRESSIVOS EM UMA POPULAÇÃO DE ÁREA URBANA.

Degree: 2006, Universidade Catolica de Pelotas

URL: http://biblioteca.ucpel.tche.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=121

►

Objetivo: Determinar a prevalência e fatores associados ao uso de antidepressivos em adultos residentes em uma área urbana. Métodos: Estudo transversal em uma amostra representativa… (more)

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Objetivo: Determinar a prevalência e fatores associados ao uso de antidepressivos em adultos residentes em uma área urbana. Métodos: Estudo transversal em uma amostra representativa de adultos com idade igual ou superior a 40 anos, moradores na zona urbana de Pelotas, Estado do Rio Grande do Sul. Os dados foram coletados por meio de um questionário padronizado e pré-codificado. Foi definido como usuário de antidepressivo o adulto que relatou ter usado medicação antidepressiva nos últimos quinze dias. Variáveis sóciodemográficas e comportamentais foram avaliadas. Para as comparações entre proporções, utilizou-se o teste de qui-quadrado e, para a análise multivariada, a regressão logística não condicional. Resultados: Foram entrevistados 1327 adultos, dos quais 9,3% tinham usado antidepressivos. O maior consumo de antidepressivos associou-se significativamente ao sexo feminino, IC 95% 2,45(1,50-4,02), ao nível sócioeconômico mais elevado (classes A e B), IC 95% 2,07(1,28 -3,34), e a não estar exercendo uma atividade de trabalho, IC 95% 1,65(1,06-2,55). Os antidepressivos do grupo dos Inibidores Seletivos da Recaptação da Serotonina (ISRS) foram os mais consumidos, 60,2%. Conclusões: A prevalência de uso de antidepressivos foi superior às encontradas em outros estudos. Os determinantes individuais de utilização, poderão servir de embasamento às estratégias para diminuir o consumo de antidepressivos nesses grupos

Objectives To estimate the prevalence and determinants of antidepressants among adults living in an urban area. Methods Transversal study in a representative sample of adults at the age of 40 years or older, living in the urban area of Pelotas, State of Rio Grande do Sul, Brazil. The data was collected through a pre-codified and standardized questionnaire. Was defined as an antidepressants user, the adult that had declared the use of antidepressant medication on the last fiftenn days. Variables were valued according to the social demographic and behavior of these individuals. The chi-squared test was used for comparisons between proportions. The non conditional logistic regression was used for multivariate analysis with robust adjustment for variances. Results Were interviewed 1327 adults, which 9,3 % had used antidepressants. The major use of antidepressants were associated significantly to the feminine gender, IC 95% 2,45 (1,50-4,02), to the upper social levels, IC 95% 2,07(0,68-1,95), and also associated to jobless subjects, 1,65(1,06-2,55). The most used antidepressants were of the Serotonin inhibiters group (ISRS), in a proportion of 60,2% of the interviewed subjects. Conclusions The prevalence of antidepressants use was superior to the ones found in other studies. These studied groups and a base to a better strategic therapy that can be elaborated to decrease the use of antidepressants in these groups Objectives To estimate the prevalence and determinants of antidepressants among adults living in an urban area. Methods Transversal study in a representative sample of adults at the age of 40 years or…

Advisors/Committee Members: Ricardo Tavares Pinheiro.

Subjects/Keywords: epidemiology; antidepressivos; adultos; epidemiologia.; antidepressants; adults; MEDICINA

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Garcias, C. M. M. (2006). PREVALÊNCIA E FATORES ASSOCIADOS AO USO DE ANTIDEPRESSIVOS EM UMA POPULAÇÃO DE ÁREA URBANA. (Thesis). Universidade Catolica de Pelotas. Retrieved from http://biblioteca.ucpel.tche.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=121

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Garcias, Carla Maria Maia. “PREVALÊNCIA E FATORES ASSOCIADOS AO USO DE ANTIDEPRESSIVOS EM UMA POPULAÇÃO DE ÁREA URBANA.” 2006. Thesis, Universidade Catolica de Pelotas. Accessed February 27, 2021. http://biblioteca.ucpel.tche.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=121.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Garcias, Carla Maria Maia. “PREVALÊNCIA E FATORES ASSOCIADOS AO USO DE ANTIDEPRESSIVOS EM UMA POPULAÇÃO DE ÁREA URBANA.” 2006. Web. 27 Feb 2021.

Vancouver:

Garcias CMM. PREVALÊNCIA E FATORES ASSOCIADOS AO USO DE ANTIDEPRESSIVOS EM UMA POPULAÇÃO DE ÁREA URBANA. [Internet] [Thesis]. Universidade Catolica de Pelotas; 2006. [cited 2021 Feb 27]. Available from: http://biblioteca.ucpel.tche.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=121.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Garcias CMM. PREVALÊNCIA E FATORES ASSOCIADOS AO USO DE ANTIDEPRESSIVOS EM UMA POPULAÇÃO DE ÁREA URBANA. [Thesis]. Universidade Catolica de Pelotas; 2006. Available from: http://biblioteca.ucpel.tche.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=121

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

McMaster University

13. Green, Alexander E. The Effects of Elevated Serotonin (5-HT) Signaling on Brown Adipose Tissue.

Degree: PhD, 2020, McMaster University

URL: http://hdl.handle.net/11375/25504

►

Inhibiting peripheral serotonin (5-HT) synthesis has been shown to prevent the development of diet-induced obesity, glucose intolerance, insulin resistance and hepatic lipid deposition and to… (more)

▼

Inhibiting peripheral serotonin (5-HT) synthesis has been shown to prevent the development of diet-induced obesity, glucose intolerance, insulin resistance and hepatic lipid deposition and to increase brown adipose tissue (BAT) thermogenic capacity. This thesis investigated 1) what effects 5-HT has on brown adipocytes (BAs), 2) if 5-HT and/or selective serotonin reuptake inhibitors (SSRIs) impair BAT function, 3) if 5-HT directly inhibits BA via a receptor-mediated mechanism, 4) which 5-HT receptor is predominantly expressed in BAT, 5) if 5-HT receptor antagonism improves BAT function and 6) if 5-HT receptor inhibition reduces SSRI induced weight gain. In murine BAs, 5-HT at concentrations ≥100 μM acutely reduced lipolysis, lipid accumulation and glycolytic flux but did not impair oxygen consumption; whereas 10 nM 5-HT reduced Ucp1 promoter activity via an extracellular receptor-mediated mechanism. Acute injection of 5-HT or the selective serotonin reuptake inhibitor (SSRI) Paroxetine decreased BA T thermogenic capacity and energy expenditure (EE), respectively. Mice lacking the serotonin transporter gene (Slc6a4-/- mice) had increased adiposity, decreased locomotor activity and increased food intake. However, male Slc6a4-/- mice had increased BAT thermogenic capacity, in contrast to the reduced EE expenditure following acute administration of Paroxetine. Using, RNA-Seq analysis and measurements of canonical 5-HT receptor second messengers (i.e. Ca2+ and cAMP transients), 5-HT2A was identified as the highest expressed 5-HT receptor in murine and human BAs and the only detected active 5-HT receptor in murine BAs. Genetic elimination of 5-HT2A prevented 5-HT induced increases in Ca2+ transient peaks and decreases in Ppargc1a mRNA expression in cultured BAs. In vivo ablation of 5-HT2A in adipose tissue increased BAT thermogenic capacity. Furthermore, in silico analyses predicted that pharmacological inhibition of 5- HT2A would induce a thermogenic program. In vitro, 5-HT2A receptor antagonists eliminated 5-HT induced Ca2+ transients and in vivo, a single injection of a peripherally-restricted 5-HT2A antagonist (Xylamidine) prevented 5-HT-induced impairments in BAT-mediated EE. Chronic administration of Xylamidine to chow- fed mice for 5-weeks improved BA T thermogenesis. Co-administration of Xylamidine with Paroxetine, however, did not attenuate Paroxetine-induced weight gain but did improve BAT functional capacity Therefore, 5-HT2A antagonism improves BAT thermogenic capacity but does not increase EE. This represents a novel therapeutic approach for increasing thermogenic capacity that may be used in conjunction with BAT activating strategies to increase EE and attenuate obesity.

Thesis

Doctor of Philosophy (PhD)

Obesity is a growing global pandemic caused by excessive energy intake over energy expenditure (EE). Some medications, such as certain selective serotonin (5-HT) reuptake inhibitor (SSRI) type antidepressants, also contribute to weight gain via reasons which are not fully understood. Currently…

Advisors/Committee Members: Steinberg, Gregory R, Medical Sciences (Cell Biology and Metabolism).

Subjects/Keywords: Serotonin; SSRI; Obesity; Brown Adipose Tissue; Antidepressants

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Green, A. E. (2020). The Effects of Elevated Serotonin (5-HT) Signaling on Brown Adipose Tissue. (Doctoral Dissertation). McMaster University. Retrieved from http://hdl.handle.net/11375/25504

Chicago Manual of Style (16^th Edition):

Green, Alexander E. “The Effects of Elevated Serotonin (5-HT) Signaling on Brown Adipose Tissue.” 2020. Doctoral Dissertation, McMaster University. Accessed February 27, 2021. http://hdl.handle.net/11375/25504.

MLA Handbook (7^th Edition):

Green, Alexander E. “The Effects of Elevated Serotonin (5-HT) Signaling on Brown Adipose Tissue.” 2020. Web. 27 Feb 2021.

Vancouver:

Green AE. The Effects of Elevated Serotonin (5-HT) Signaling on Brown Adipose Tissue. [Internet] [Doctoral dissertation]. McMaster University; 2020. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/11375/25504.

Council of Science Editors:

Green AE. The Effects of Elevated Serotonin (5-HT) Signaling on Brown Adipose Tissue. [Doctoral Dissertation]. McMaster University; 2020. Available from: http://hdl.handle.net/11375/25504

Rhodes University

14. Kok, Eric Charl. The study of the potentiation of anticholinergic side effects of tricyclic antidepressives by female sex steroids.

Degree: Faculty of Pharmacy, Pharmacy, 1981, Rhodes University

URL: http://hdl.handle.net/10962/d1005623

► It has been recorded that women respond to tricyclic antidepressives with a greater incidence of anticholinergic side effects than men do, particularly women taking an… (more)

Subjects/Keywords: Antidepressants; Steroid hormones

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APA (6^th Edition):

Kok, E. C. (1981). The study of the potentiation of anticholinergic side effects of tricyclic antidepressives by female sex steroids. (Thesis). Rhodes University. Retrieved from http://hdl.handle.net/10962/d1005623

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kok, Eric Charl. “The study of the potentiation of anticholinergic side effects of tricyclic antidepressives by female sex steroids.” 1981. Thesis, Rhodes University. Accessed February 27, 2021. http://hdl.handle.net/10962/d1005623.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kok, Eric Charl. “The study of the potentiation of anticholinergic side effects of tricyclic antidepressives by female sex steroids.” 1981. Web. 27 Feb 2021.

Vancouver:

Kok EC. The study of the potentiation of anticholinergic side effects of tricyclic antidepressives by female sex steroids. [Internet] [Thesis]. Rhodes University; 1981. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10962/d1005623.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kok EC. The study of the potentiation of anticholinergic side effects of tricyclic antidepressives by female sex steroids. [Thesis]. Rhodes University; 1981. Available from: http://hdl.handle.net/10962/d1005623

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Otago

15. Deng, Xiaoyan. Gene Regulation by Drugs Used to Treat Mood Disorders .

Degree: 2011, University of Otago

URL: http://hdl.handle.net/10523/1806

► Mood disorders such as Major Depressive Disorder and Bipolar Disorder are devastating burdens upon sufferers, their families and society as a whole. Despite their high… (more)

▼ Mood disorders such as Major Depressive Disorder and Bipolar Disorder are devastating burdens upon sufferers, their families and society as a whole. Despite their high prevalence and socioeconomic impact, understanding the aetiology of mood disorders has proved difficult, due in part to the heterogeneity observed in disorders of mental well-being. Antidepressant and mood stabiliser drugs are the main treatment for mood disorders. Although highly efficacious, the mechanisms of action of these drugs are not well understood. This project aimed to establish the effects of such drugs on gene regulation, and in doing so, advance the field by detecting specific transcripts and biochemical pathways involved in drug response. It was anticipated that this knowledge would prove valuable for developing novel therapeutic and treatment options of the future. Initial work focused upon promoter regions of candidate genes chosen from the literature and previous results from our laboratory. Nineteen constructs were investigated in the rat serotonergic cell line RN46A, using a luciferase reporter assay and a commonly prescribed SSRI antidepressant paroxetine. Although significant differences in expression were noted between drug-exposed and control cell cultures, the system proved inconsistent, despite considerable care in experimental design and execution. A more direct approach, real-time quantitative PCR (qPCR), was then utilised to detect drug-induced gene expression differences in RN46A cells. Five drugs were used: the antidepressants paroxetine, citalopram and nortriptyline; the antipsychotic haloperidol; and the mood stabiliser sodium valproate. Of five potential reference genes for normalization of qPCR experiments, Actb, G6pd and Rnf4 were stably expressed over differing treatments. I screened thirty-nine candidate genes for expression changes attributable to drug exposure. The most striking result was a reproducible ~1700-fold up-regulation of sepiapterin reductase (SPR), by the drug sodium valproate. SPR encodes a key enzyme for neurotransmitter synthesis. Qdpr, encoding a protein in the same pathway, was also up-regulated by valproate, but to a lesser extent. SPR and members of the biopterin biosynthesis pathway have previously been implicated in the biology of depression. Another gene, the serotonin receptor 2A (Htr2a) was significantly down-regulated by the SSRIs paroxetine and citalopram. Having identified that valproate induced the most significant gene expression changes,I further conducted time-course and dose-response experiments to investigate the dynamics and pharmacology of valproate- induced gene expression changes. Spr and Hdac6, a member of the histone deacetylase gene family, were found to behave differently in these experiments. Subsequently, western blotting confirmed increased SPR protein expression in treated cells, and detected at least three isoforms recognised by a commercially sourced SPR antibody. Attempts to identify signalling pathways regulated by valproate failed to detect significant… Advisors/Committee Members: Kennedy, Martin (advisor).

Subjects/Keywords: gene regulation; mood disorders; antidepressants; sodium valproate

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Deng, X. (2011). Gene Regulation by Drugs Used to Treat Mood Disorders . (Doctoral Dissertation). University of Otago. Retrieved from http://hdl.handle.net/10523/1806

Chicago Manual of Style (16^th Edition):

Deng, Xiaoyan. “Gene Regulation by Drugs Used to Treat Mood Disorders .” 2011. Doctoral Dissertation, University of Otago. Accessed February 27, 2021. http://hdl.handle.net/10523/1806.

MLA Handbook (7^th Edition):

Deng, Xiaoyan. “Gene Regulation by Drugs Used to Treat Mood Disorders .” 2011. Web. 27 Feb 2021.

Vancouver:

Deng X. Gene Regulation by Drugs Used to Treat Mood Disorders . [Internet] [Doctoral dissertation]. University of Otago; 2011. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10523/1806.

Council of Science Editors:

Deng X. Gene Regulation by Drugs Used to Treat Mood Disorders . [Doctoral Dissertation]. University of Otago; 2011. Available from: http://hdl.handle.net/10523/1806

University of Ottawa

16. Vahid-Ansari, Faranak. Altered Serotonin Regulation in Genetic and Post-Stroke Models of Anxiety and Depression .

Degree: 2017, University of Ottawa

URL: http://hdl.handle.net/10393/36839

► Major depression is a complex disease involving genetic and environmental factors. Previous studies suggest that functional genetic polymorphisms that alter the serotonin (5-HT) system in… (more)

▼ Major depression is a complex disease involving genetic and environmental factors. Previous studies suggest that functional genetic polymorphisms that alter the serotonin (5-HT) system in combination with psychosocial stress can synergistically increase the strength of these associations. In addition, depression is associated with several neurological disorders involving neuronal injury, including stroke (i.e. post-stroke depression, PSD). Both forms of depression are treated with 5-HT-selective antidepressants like fluoxetine, but remission rates do not exceed 50%. Evidence showed that alterations affecting the 5-HT system, directly or indirectly, lead to anxiety or depression phenotypes and may elucidate determinants of response to antidepressants. To better understand common and unique alterations in both genetic- and injury-related depression, I have generated and investigated two novel mouse models that exemplify a serotonin-related genetic risk (Flx-Freud-1 mice) and an injury model (ischemic lesion), to identify similarities and differences in their behavioral phenotypes, and in response to fluoxetine treatment. In the Flx-Freud-1 mouse model, 5-HT neuron-specific adult knockout of Freud-1, a key repressor of the 5-HT1A receptor gene, led to overexpression of 5-HT1A autoreceptors thought to negatively regulate the 5-HT system. These mice showed increased 5-HT1A autoreceptor responses, reduced 5-HT levels and a robust anxiety and depression phenotype that was resistant to chronic fluoxetine treatment. These behaviors were dependent on increased 5-HT1A autoreceptors since they were not seen in mice lacking 5-HT1A autoreceptors in adult Freud-1 knockout background. Instead an opposite anti-depressed phenotype emerged, suggesting that Freud-1 might have additional functions in 5-HT cells. In the PSD model, the vasoconstrictor endothelin-1 was injected to induce transient ischemia in the left medial prefrontal cortex, iv part of the circuitry thought to be damaged in PSD in humans. This stroke resulted in a persistent anxiety, depression and cognitive impairment. Chronic fluoxetine treatment alone or combined with voluntary exercise was effective to reverse the behavioral and cognitive phenotypes in this PSD mouse model.The results of genetic and SSRI treated stroke models show that changes in 5-HT system contribute to widespread dysregulation of the neuronal circuitry implicated in depression, anxiety. Genetic alteration of the 5-HT system conferred fluoxetine-resistance, while cortical stroke which indirectly altered the 5-HT system remained responsive to fluoxetine. Following unilateral stroke, there was increased activity of the contralateral hemisphere, including the prefrontal cortex and limbic areas involved in anxiety and depression, and activation of the 5-HT system. Effective treatment with chronic fluoxetine alone or combined with exercise significantly reduced and balanced the contralesional neuronal activation in affected regions that correlated with improvements in phenotypes. In conclusion, this…

Subjects/Keywords: Serotonin; Antidepressants; Depression; Anxiety; Genetics; Stroke

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Vahid-Ansari, F. (2017). Altered Serotonin Regulation in Genetic and Post-Stroke Models of Anxiety and Depression . (Thesis). University of Ottawa. Retrieved from http://hdl.handle.net/10393/36839

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Vahid-Ansari, Faranak. “Altered Serotonin Regulation in Genetic and Post-Stroke Models of Anxiety and Depression .” 2017. Thesis, University of Ottawa. Accessed February 27, 2021. http://hdl.handle.net/10393/36839.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Vahid-Ansari, Faranak. “Altered Serotonin Regulation in Genetic and Post-Stroke Models of Anxiety and Depression .” 2017. Web. 27 Feb 2021.

Vancouver:

Vahid-Ansari F. Altered Serotonin Regulation in Genetic and Post-Stroke Models of Anxiety and Depression . [Internet] [Thesis]. University of Ottawa; 2017. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10393/36839.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Vahid-Ansari F. Altered Serotonin Regulation in Genetic and Post-Stroke Models of Anxiety and Depression . [Thesis]. University of Ottawa; 2017. Available from: http://hdl.handle.net/10393/36839

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Vrije Universiteit Amsterdam

17. Kieviet, N. Neonatal symptoms after exposure to antidepressants in utero .

Degree: 2016, Vrije Universiteit Amsterdam

URL: http://hdl.handle.net/1871/53868

Subjects/Keywords: antidepressants pregnancy withdrawal

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kieviet, N. (2016). Neonatal symptoms after exposure to antidepressants in utero . (Doctoral Dissertation). Vrije Universiteit Amsterdam. Retrieved from http://hdl.handle.net/1871/53868

Chicago Manual of Style (16^th Edition):

Kieviet, N. “Neonatal symptoms after exposure to antidepressants in utero .” 2016. Doctoral Dissertation, Vrije Universiteit Amsterdam. Accessed February 27, 2021. http://hdl.handle.net/1871/53868.

MLA Handbook (7^th Edition):

Kieviet, N. “Neonatal symptoms after exposure to antidepressants in utero .” 2016. Web. 27 Feb 2021.

Vancouver:

Kieviet N. Neonatal symptoms after exposure to antidepressants in utero . [Internet] [Doctoral dissertation]. Vrije Universiteit Amsterdam; 2016. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/1871/53868.

Council of Science Editors:

Kieviet N. Neonatal symptoms after exposure to antidepressants in utero . [Doctoral Dissertation]. Vrije Universiteit Amsterdam; 2016. Available from: http://hdl.handle.net/1871/53868

Columbia University

18. Kruegel, Andrew Carry. Chemical and Biological Explorations of Novel Opioid Receptor Modulators.

Degree: 2015, Columbia University

URL: https://doi.org/10.7916/D8V1242F

► This report describes the synthesis, chemical derivation, and pharmacological and behavioral characterization of several unique classes of opioid receptor modulators. In chapter one, a general… (more)

▼ This report describes the synthesis, chemical derivation, and pharmacological and behavioral characterization of several unique classes of opioid receptor modulators. In chapter one, a general overview of opioid receptor history, signaling biology, and therapeutic applications is provided. Also reviewed are several topics of high current interest, including, biased signaling, opioid receptor splice variants/heteromers, and applications of opioid modulators in the treatment of mood disorders. This introduction aims to frame the work that follows, and emphasize to the reader the untapped potential of the opioid receptor system, particularly in the realm of therapeutics development. Chapter two discusses the development of several new C-H activation reactions to provide rapid access to the core molecular scaffold of alkaloids from Tabernanthe iboga. The methods described permit the expedient construction of structurally diverse ibogamine analogs via a modular approach. In chapter three, this work is extended by applying the new reaction methodologies to explore a novel class of oxaibogamine analogs, which act as opioid receptor agonists and antagonists. The thorough exploration of structure-activity relationships within this skeleton is described, along with the pharmacological characterization of several select analogs as biased agonists at both the kappa- and mu-opioid receptors. This section concludes with a discussion of potential therapeutic applications for the synthesized compounds as new analgesics and antidepressants, and future goals and plans for this structural class. In chapter four, the isolation and pharmacological study of several alkaloids of Mitragyna speciosa is presented. Mitragynine, the primary natural alkaloid in this plant, is isolated, along with several naturally occurring analogs, and the modulatory activity of these compounds at the opioid receptors is fully characterized. Further, preliminary results are presented suggesting activity of these alkaloids at several other classes of central nervous system targets, including serotonin and adrenergic receptors. Also discussed are the preparations of semi-synthetic and fully synthetic mitragynine derivatives, including a total synthesis of mitragynine itself. These novel analogs are applied to explore key structure-activity relationships in this unusual opioid-active scaffold. Again, potential applications of Mitragyna alkaloid analogs in the treatment of pain and depression are discussed. In the final chapter, I describe our discovery that tianeptine, a clinically used atypical antidepressant of previously unknown mechanism of action, acts as an agonist of both the mu- and delta-opioid receptors. Activation of the mu-opioid receptor is thus proposed as the initial molecular-level event responsible for eliciting the beneficial therapeutic effects of this agent. This hypothesis is integrated with the large body of literature describing this compound, and mechanistic theories connecting the opioid activity of tianeptine to…

Subjects/Keywords: Opioids – Receptors; Antidepressants; Therapeutics; Chemistry; Pharmacology

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APA (6^th Edition):

Kruegel, A. C. (2015). Chemical and Biological Explorations of Novel Opioid Receptor Modulators. (Doctoral Dissertation). Columbia University. Retrieved from https://doi.org/10.7916/D8V1242F

Chicago Manual of Style (16^th Edition):

Kruegel, Andrew Carry. “Chemical and Biological Explorations of Novel Opioid Receptor Modulators.” 2015. Doctoral Dissertation, Columbia University. Accessed February 27, 2021. https://doi.org/10.7916/D8V1242F.

MLA Handbook (7^th Edition):

Kruegel, Andrew Carry. “Chemical and Biological Explorations of Novel Opioid Receptor Modulators.” 2015. Web. 27 Feb 2021.

Vancouver:

Kruegel AC. Chemical and Biological Explorations of Novel Opioid Receptor Modulators. [Internet] [Doctoral dissertation]. Columbia University; 2015. [cited 2021 Feb 27]. Available from: https://doi.org/10.7916/D8V1242F.

Council of Science Editors:

Kruegel AC. Chemical and Biological Explorations of Novel Opioid Receptor Modulators. [Doctoral Dissertation]. Columbia University; 2015. Available from: https://doi.org/10.7916/D8V1242F

Central Connecticut State University

19. Colon, Analix, 1977-. Biological aspects of depression and antidepressants / Analix Colon.

Degree: Department of Biomolecular Sciences, 2003, Central Connecticut State University

URL: http://content.library.ccsu.edu/u?/ccsutheses,1506

► Depression is characterized by a mood and behavior, that can affect the ability of a person to perform daily activities and interact with others. Depression… (more)

Subjects/Keywords: Depression, Mental; Antidepressants

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APA (6^th Edition):

Colon, Analix, 1. (2003). Biological aspects of depression and antidepressants / Analix Colon. (Thesis). Central Connecticut State University. Retrieved from http://content.library.ccsu.edu/u?/ccsutheses,1506

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Colon, Analix, 1977-. “Biological aspects of depression and antidepressants / Analix Colon.” 2003. Thesis, Central Connecticut State University. Accessed February 27, 2021. http://content.library.ccsu.edu/u?/ccsutheses,1506.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Colon, Analix, 1977-. “Biological aspects of depression and antidepressants / Analix Colon.” 2003. Web. 27 Feb 2021.

Vancouver:

Colon, Analix 1. Biological aspects of depression and antidepressants / Analix Colon. [Internet] [Thesis]. Central Connecticut State University; 2003. [cited 2021 Feb 27]. Available from: http://content.library.ccsu.edu/u?/ccsutheses,1506.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Colon, Analix 1. Biological aspects of depression and antidepressants / Analix Colon. [Thesis]. Central Connecticut State University; 2003. Available from: http://content.library.ccsu.edu/u?/ccsutheses,1506

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Illinois – Chicago

20. Wray, Nathan. NMDA Receptor Independent, Astrocytic Antidepressant Actions of Ketamine.

Degree: 2018, University of Illinois – Chicago

URL: http://hdl.handle.net/10027/23089

► Depression is a devastating mental illness that robs many of ability to experience the tremendous joy of being alive. It is diagnosed by its symptoms,… (more)

Subjects/Keywords: depression; antidepressants; ketamine; G-proteins; Lipid Rafts

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wray, N. (2018). NMDA Receptor Independent, Astrocytic Antidepressant Actions of Ketamine. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/23089

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wray, Nathan. “NMDA Receptor Independent, Astrocytic Antidepressant Actions of Ketamine.” 2018. Thesis, University of Illinois – Chicago. Accessed February 27, 2021. http://hdl.handle.net/10027/23089.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wray, Nathan. “NMDA Receptor Independent, Astrocytic Antidepressant Actions of Ketamine.” 2018. Web. 27 Feb 2021.

Vancouver:

Wray N. NMDA Receptor Independent, Astrocytic Antidepressant Actions of Ketamine. [Internet] [Thesis]. University of Illinois – Chicago; 2018. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10027/23089.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wray N. NMDA Receptor Independent, Astrocytic Antidepressant Actions of Ketamine. [Thesis]. University of Illinois – Chicago; 2018. Available from: http://hdl.handle.net/10027/23089

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

21. Seguini, Mara. Analysis of miRNome expression profile in hippocampus of rats treated with antidepressants.

Degree: 2015, Università degli Studi di Catania

URL: http://hdl.handle.net/10761/1708

► MicroRNAs (miRNAs) are small, non-coding RNAs with a key role in regulating gene expression at post-transcriptional level. Recent investigations suggested that dysregulation in miRNA expression… (more)

▼ MicroRNAs (miRNAs) are small, non-coding RNAs with a key role in regulating gene expression at post-transcriptional level. Recent investigations suggested that dysregulation in miRNA expression may be critical for mental disorders pathophysiology, including mood disorders, and in psychotropic drugs action, such as mood stabilizers and antidepressants (ADs). Aim of the studies presented was to analyze whether modulation of hippocampal miRNome could be part of the mode of action of different ADs, fluoxetine, desipramine and agomelatine. Moreover, in order to assess the time course of ADs effects, treatments were performed for various time lengths (3,7 or 21 days). Rat hippocampal miRNome expression was investigated by means of TaqMan Rodent MicroRNA Arrays. We found that all ADs induced a significant modulation of hippocampal miRNome, although with different time-dependent effects. Indeed, all ADs significant modulated miRNA expression already after 3 days of treatment with the most pronounced effect by agomelatine (37 miRNAs, mainly down-regulated); whereas both fluoxetine and desipramine modified the expression of 8 different miRNAs. After 7 days, the greater number of miRNAs was modulated by fluoxetine (35 miRNAs, mainly up-regulated), while desipramine and agomelatine modulated the expression of 13 and 22 miRNAs, respectively. Finally, 21 days of agomelatine treatment modulated the expression of 6 miRNAs. Interestingly, some of the miRNAs were found to be similarly affected by at least two of the different ADs. A bio-informatic analysis allowed the identification of putative miRNA targets and signalling pathways modulated by the identified miRNAs. The predicted target genes of miRNAs are involved in several pathways related to neuronal functions and ADs mechanism of action; moreover, many of the putative target genes, in particular those of miRs modulated by agomelatine, are enriched in pathways related to DNA/RNA regulation and epigenetic mechanisms. A number of putative miRNA target genes have been selected for validation studies by means of mRNA/protein expression analyses. The results of these work, showing that AD treatments induce early and time-dependent modifications in the expression of hippocampal miRNAs, could be of help to better clarify the ADs mechanism of action and to identify new putative targets for the development of novel drugs with greater efficacy and a more rapid onset of action.

Subjects/Keywords: Area 06 - Scienze mediche; miRNOme, hippocampus, antidepressants

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Seguini, M. (2015). Analysis of miRNome expression profile in hippocampus of rats treated with antidepressants. (Thesis). Università degli Studi di Catania. Retrieved from http://hdl.handle.net/10761/1708

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Seguini, Mara. “Analysis of miRNome expression profile in hippocampus of rats treated with antidepressants.” 2015. Thesis, Università degli Studi di Catania. Accessed February 27, 2021. http://hdl.handle.net/10761/1708.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Seguini, Mara. “Analysis of miRNome expression profile in hippocampus of rats treated with antidepressants.” 2015. Web. 27 Feb 2021.

Vancouver:

Seguini M. Analysis of miRNome expression profile in hippocampus of rats treated with antidepressants. [Internet] [Thesis]. Università degli Studi di Catania; 2015. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10761/1708.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Seguini M. Analysis of miRNome expression profile in hippocampus of rats treated with antidepressants. [Thesis]. Università degli Studi di Catania; 2015. Available from: http://hdl.handle.net/10761/1708

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

22. Bruijn, Jan. "New" better than "old"? : detection of differences in efficacy between treatments in depressed inpatients under optimal conditions.

Degree: Department of Psychiatry, 2001, Erasmus University Medical Center

URL: http://hdl.handle.net/1765/22847

Subjects/Keywords: antidepressants; psychiatry; psychopathology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bruijn, J. (2001). "New" better than "old"? : detection of differences in efficacy between treatments in depressed inpatients under optimal conditions. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/22847

Chicago Manual of Style (16^th Edition):

Bruijn, Jan. “"New" better than "old"? : detection of differences in efficacy between treatments in depressed inpatients under optimal conditions.” 2001. Doctoral Dissertation, Erasmus University Medical Center. Accessed February 27, 2021. http://hdl.handle.net/1765/22847.

MLA Handbook (7^th Edition):

Bruijn, Jan. “"New" better than "old"? : detection of differences in efficacy between treatments in depressed inpatients under optimal conditions.” 2001. Web. 27 Feb 2021.

Vancouver:

Bruijn J. "New" better than "old"? : detection of differences in efficacy between treatments in depressed inpatients under optimal conditions. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2001. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/1765/22847.

Council of Science Editors:

Bruijn J. "New" better than "old"? : detection of differences in efficacy between treatments in depressed inpatients under optimal conditions. [Doctoral Dissertation]. Erasmus University Medical Center; 2001. Available from: http://hdl.handle.net/1765/22847

Queens University

23. Kennedy, Gregory L. The Effect of Antidepressants on Cardiovascular Morbidity and Mortality: A Population-based Cohort Study .

Degree: Community Health and Epidemiology, 2007, Queens University

URL: http://hdl.handle.net/1974/680

► Background: Antidepressants such as selective serotonin reuptake inhibitors (SSRIs) and venlafaxine have the potential to exert beneficial effects on the heart via serotonin mediated antiplatelet… (more)

▼ Background: Antidepressants such as selective serotonin reuptake inhibitors (SSRIs) and venlafaxine have the potential to exert beneficial effects on the heart via serotonin mediated antiplatelet activity. However, previous evidence regarding the cardiovascular effects of these agents has been conflicting. There is a need for further investigation into the risks and benefits of these drugs. Objective: To assess the risk of acute MI and cardiac death associated the use of various classes of antidepressants, and determine whether this risk is modified by the presence of predisposing factors. Methods: We identified a population-based, retrospective cohort study of 71,253 elderly persons initiating treatment with an antidepressant between 1997 and 2004. The cohort was analyzed using nested case-control approach with each case of acute MI or cardiac death matched with up to 20 controls according to age (±1 year), duration of follow-up, and year of cohort entry. Rate ratios for acute MI and cardiac death associated with the current use of various antidepressants were estimated using conditional logistic regression and adjusted for potential confounders. Results: Compared with the current use of atypical antidepressants, current use of venlafaxine was associated with a significant reduction in the risk of MI and cardiac death (rate ratio [RR] 0.80 [95% CI 0.66 to 0.97]) that was more pronounced in persons with established cardiovascular disease (CVD) (RR 0.65 [CI 0.50 to 0.86]). We found no clear evidence of a benefit or harm associated with the use of SSRIs (RR 0.92 [CI 0.79 to 1.06]), although there was the suggestion of a clinically important benefit from treatment with SSRIs for individuals who had history of MI (RR 0.68 [CI 0.44 to 1.07]). No benefit or harm was observed with other classes of antidepressants. Conclusions: These results demonstrate a reduced risk for acute MI and cardiac death associated with current use of venlafaxine among elderly persons. This beneficial effect appears to be more pronounced in those with established cardiovascular disease. No clear evidence of benefit on CV outcomes was associated with the current use of SSRIs, although results suggest a potential benefit for use in persons with a previous MI.

Subjects/Keywords: antidepressants ; cardiovascular risk

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APA (6^th Edition):

Kennedy, G. L. (2007). The Effect of Antidepressants on Cardiovascular Morbidity and Mortality: A Population-based Cohort Study . (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/680

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kennedy, Gregory L. “The Effect of Antidepressants on Cardiovascular Morbidity and Mortality: A Population-based Cohort Study .” 2007. Thesis, Queens University. Accessed February 27, 2021. http://hdl.handle.net/1974/680.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kennedy, Gregory L. “The Effect of Antidepressants on Cardiovascular Morbidity and Mortality: A Population-based Cohort Study .” 2007. Web. 27 Feb 2021.

Vancouver:

Kennedy GL. The Effect of Antidepressants on Cardiovascular Morbidity and Mortality: A Population-based Cohort Study . [Internet] [Thesis]. Queens University; 2007. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/1974/680.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kennedy GL. The Effect of Antidepressants on Cardiovascular Morbidity and Mortality: A Population-based Cohort Study . [Thesis]. Queens University; 2007. Available from: http://hdl.handle.net/1974/680

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Erasmus University Rotterdam

24. Molenaar, Nina. Antidepressants in the Perinatal Period : challenging choices in current practice.

Degree: 2018, Erasmus University Rotterdam

URL: http://hdl.handle.net/1765/112211

► Since much has already been written about the relation between antidepressants during pregnancy and increased risks in the offspring, the aim of this thesis is… (more)

Subjects/Keywords: Pregnancy; antidepressants; depression

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Molenaar, N. (2018). Antidepressants in the Perinatal Period : challenging choices in current practice. (Doctoral Dissertation). Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/112211

Chicago Manual of Style (16^th Edition):

Molenaar, Nina. “Antidepressants in the Perinatal Period : challenging choices in current practice.” 2018. Doctoral Dissertation, Erasmus University Rotterdam. Accessed February 27, 2021. http://hdl.handle.net/1765/112211.

MLA Handbook (7^th Edition):

Molenaar, Nina. “Antidepressants in the Perinatal Period : challenging choices in current practice.” 2018. Web. 27 Feb 2021.

Vancouver:

Molenaar N. Antidepressants in the Perinatal Period : challenging choices in current practice. [Internet] [Doctoral dissertation]. Erasmus University Rotterdam; 2018. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/1765/112211.

Council of Science Editors:

Molenaar N. Antidepressants in the Perinatal Period : challenging choices in current practice. [Doctoral Dissertation]. Erasmus University Rotterdam; 2018. Available from: http://hdl.handle.net/1765/112211

University of Alberta

25. Todd, Kathryn Grace. Gabaergic mechanisms of the antidepressant/antipanic drug phenelzine.

Degree: PhD, Faculty of Pharmacy and Pharmaceutical Sciences Faculty of Medicine, 1994, University of Alberta

URL: https://era.library.ualberta.ca/files/6969z336h

Subjects/Keywords: GABA – Effect of antidepressants on.; Antidepressants.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Todd, K. G. (1994). Gabaergic mechanisms of the antidepressant/antipanic drug phenelzine. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/6969z336h

Chicago Manual of Style (16^th Edition):

Todd, Kathryn Grace. “Gabaergic mechanisms of the antidepressant/antipanic drug phenelzine.” 1994. Doctoral Dissertation, University of Alberta. Accessed February 27, 2021. https://era.library.ualberta.ca/files/6969z336h.

MLA Handbook (7^th Edition):

Todd, Kathryn Grace. “Gabaergic mechanisms of the antidepressant/antipanic drug phenelzine.” 1994. Web. 27 Feb 2021.

Vancouver:

Todd KG. Gabaergic mechanisms of the antidepressant/antipanic drug phenelzine. [Internet] [Doctoral dissertation]. University of Alberta; 1994. [cited 2021 Feb 27]. Available from: https://era.library.ualberta.ca/files/6969z336h.

Council of Science Editors:

Todd KG. Gabaergic mechanisms of the antidepressant/antipanic drug phenelzine. [Doctoral Dissertation]. University of Alberta; 1994. Available from: https://era.library.ualberta.ca/files/6969z336h

26. Silva, William Kleber da. Desenvolvimento e validação de análise de duloxetina em plasma humano, simultânea a outros antidepressivos, por cromatografia líquida de alta eficiência.

Degree: Mestrado, Toxicologia, 2014, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/60/60134/tde-27112014-144038/ ;

►

Atualmente, a quantidade de pacientes que são diagnosticados com alguma forma de depressão, entre elas, o transtorno depressivo maior, aumenta consideravelmente, quer seja em razão… (more)

▼

Atualmente, a quantidade de pacientes que são diagnosticados com alguma forma de depressão, entre elas, o transtorno depressivo maior, aumenta consideravelmente, quer seja em razão de diagnósticos mais precisos ou pela própria epidemiologia da doença. Acresça-se o fato de que muitos pacientes, apesar da quantidade de tipos de antidepressivos atualmente disponíveis para a terapêutica, são refratários ao tratamento prescrito, em razão dos efeitos adversos apresentados, ou de seus efeitos tóxicos, ou ainda por simplesmente não se observar melhora com a prescrição seguida. Portanto, novos tratamentos farmacológicos são disponibilizados, e entre eles, a duloxetina, um duplo inibidor de recaptação de serotonina e norepinefrina. Para auxiliar na máxima eficácia em sua utilização, esse trabalho apresenta metodologia em HPLC para determinação simultânea de sete antidepressivos, tricíclicos e não tricíclicos, moclobemida, venlafaxina, citalopram, agomelatina, duloxetina, amitriptilina e sertralina, em plasma humano, para posteriormente ser aplicada na monitorização de pacientes depressivos. O simples e preciso método de preparo da amostra consiste na extração líquido-líquido, com recuperação entre 73% a 86% (exceto para moclobemida, de 55%), e para a duloxetina, de aproximadamente 73%. A separação foi obtida usando uma coluna em fase reversa Lichrospher® 60 RP-select B em LichroCART 250mm x 4mm, 5?m de diâmetro interno, Merck, sob condições isocráticas, com detecção em UV em 230nm, com fase móvel composta por 35% de uma mistura de acetonitrila:metanol 55/5 (v/v) e 65% de tampão acetato 0,25M, pH 4,4. As curvas padrões foram lineares em uma faixa de trabalho de 2,5-1000ng/mL para moclobemida, 5-2000ng/mL para venlafaxina, citalopram, agomelatina, duloxetina e amitriptilina, e 10-2000ng/mL para sertralina. As precisões intra e interensaios foram efetuadas em três concentrações (50, 200 e 500ng/mL). Os coeficientes de variação para a precisão intraensaio foram menores que 8,6% para todos os compostos e os coeficientes de variação para a precisão interensaio foram menores que 8,5%. Os limites de quantificação foram de 2,5ng/mL para a moclobemida, 5ng/mL para venlafaxina, citalopram, duloxetina, agomelatina, amitriptilina e 10ng/mL para sertralina. Não se observou qualquer interferência das drogas normalmente associadas aos antidepressivos.

Currently, the number of patients who are diagnosed with some form of depression, among them, major depressive disorder, increases considerably, either because of more accurate diagnosis or by the epidemiology of the disease. One should add the fact that many patients, despite the amount of types of antidepressants currently available for therapy are refractory to the treatment prescribed, because of the adverse effects appear, or their toxic effects, or by simply not observed improvement then the prescription. Therefore, new pharmacological treatments are available, and among them, duloxetine, a dual reuptake inhibitor of serotonin and norepinephrine. To assist in maximum effectiveness in…

Advisors/Committee Members: Queiroz, Regina Helena Costa.

Subjects/Keywords: antidepressivos não tricíclicos; antidepressivos tricíclicos; detecção por UV; HPLC; HPLC; monitorização terapêutica; not tricyclic antidepressants; therapeutic monitoring; tricyclic antidepressants; UV detection

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Silva, W. K. d. (2014). Desenvolvimento e validação de análise de duloxetina em plasma humano, simultânea a outros antidepressivos, por cromatografia líquida de alta eficiência. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/60/60134/tde-27112014-144038/ ;

Chicago Manual of Style (16^th Edition):

Silva, William Kleber da. “Desenvolvimento e validação de análise de duloxetina em plasma humano, simultânea a outros antidepressivos, por cromatografia líquida de alta eficiência.” 2014. Masters Thesis, University of São Paulo. Accessed February 27, 2021. http://www.teses.usp.br/teses/disponiveis/60/60134/tde-27112014-144038/ ;.

MLA Handbook (7^th Edition):

Silva, William Kleber da. “Desenvolvimento e validação de análise de duloxetina em plasma humano, simultânea a outros antidepressivos, por cromatografia líquida de alta eficiência.” 2014. Web. 27 Feb 2021.

Vancouver:

Silva WKd. Desenvolvimento e validação de análise de duloxetina em plasma humano, simultânea a outros antidepressivos, por cromatografia líquida de alta eficiência. [Internet] [Masters thesis]. University of São Paulo; 2014. [cited 2021 Feb 27]. Available from: http://www.teses.usp.br/teses/disponiveis/60/60134/tde-27112014-144038/ ;.

Council of Science Editors:

Silva WKd. Desenvolvimento e validação de análise de duloxetina em plasma humano, simultânea a outros antidepressivos, por cromatografia líquida de alta eficiência. [Masters Thesis]. University of São Paulo; 2014. Available from: http://www.teses.usp.br/teses/disponiveis/60/60134/tde-27112014-144038/ ;

University of Florida

27. Mills, Jon C. Comparative Effectiveness of Dual-Action versus Single-Action Antidepressants for Treatment of People Diagnosed with Co-Occurring HIV/AIDS and Major Depression A Growing Syndemic.

Degree: PhD, Health Services Research - Health Services Research, Management, and Policy, 2016, University of Florida

URL: https://ufdc.ufl.edu/UFE0050147

► Major depressive disorder is the most common psychiatric comorbidity among people living with HIV/AIDS. It is linked to poor antiretroviral adherence, increased viral loads, low… (more)

Subjects/Keywords: Antidepressants; Anxiety; Art periods; Diagnostic indices; HIV; Major depressive disorder; Medications; Modeling; Statistical significance; Viral load; antidepressants – comparative – depression – effectiveness – hiv

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mills, J. C. (2016). Comparative Effectiveness of Dual-Action versus Single-Action Antidepressants for Treatment of People Diagnosed with Co-Occurring HIV/AIDS and Major Depression A Growing Syndemic. (Doctoral Dissertation). University of Florida. Retrieved from https://ufdc.ufl.edu/UFE0050147

Chicago Manual of Style (16^th Edition):

Mills, Jon C. “Comparative Effectiveness of Dual-Action versus Single-Action Antidepressants for Treatment of People Diagnosed with Co-Occurring HIV/AIDS and Major Depression A Growing Syndemic.” 2016. Doctoral Dissertation, University of Florida. Accessed February 27, 2021. https://ufdc.ufl.edu/UFE0050147.

MLA Handbook (7^th Edition):

Mills, Jon C. “Comparative Effectiveness of Dual-Action versus Single-Action Antidepressants for Treatment of People Diagnosed with Co-Occurring HIV/AIDS and Major Depression A Growing Syndemic.” 2016. Web. 27 Feb 2021.

Vancouver:

Mills JC. Comparative Effectiveness of Dual-Action versus Single-Action Antidepressants for Treatment of People Diagnosed with Co-Occurring HIV/AIDS and Major Depression A Growing Syndemic. [Internet] [Doctoral dissertation]. University of Florida; 2016. [cited 2021 Feb 27]. Available from: https://ufdc.ufl.edu/UFE0050147.

Council of Science Editors:

Mills JC. Comparative Effectiveness of Dual-Action versus Single-Action Antidepressants for Treatment of People Diagnosed with Co-Occurring HIV/AIDS and Major Depression A Growing Syndemic. [Doctoral Dissertation]. University of Florida; 2016. Available from: https://ufdc.ufl.edu/UFE0050147

University of KwaZulu-Natal

28. Kaja, Humraaz. The safety profile of Vilazodone: a study on post-marketing surveillance.

Degree: 2020, University of KwaZulu-Natal

URL: https://researchspace.ukzn.ac.za/handle/10413/19010

► Vilazodone was approved in 2011 as an antidepressant to treat major depressive disorder. Like other antidepressants, vilazodone has adverse effects associated with the use of… (more)

▼ Vilazodone was approved in 2011 as an antidepressant to treat major depressive disorder. Like other antidepressants, vilazodone has adverse effects associated with the use of the drug. Being a relatively new drug, it is not clear if all adverse effects have been identified yet. The aim of this study was therefore to review the adverse effects reported to the WHO Programme for International Drug Monitoring (PIDM). This study then went on to explore the psychiatric adverse effects associated with the use of vilazodone and the factors that have been hypothesized as being responsible for these effects. This study aims to provide a critical summation of present findings to add to the knowledge about the safety profile and adverse effects caused by vilazodone. Method Data on adverse effects reported for vilazodone was obtained from the database VigiAccess managed by PIDM. Data was extracted from VigiAccess using Excel® and analysed using descriptive statistics. The data collected was compared to the patient information leaflet (PIL) of Viibryd® and the FDA documents to determine adverse drug reactions reported post marketing. In order to further explore the psychiatric adverse effects associated with vilazodone, a systematic review was conducted. Databases and reference lists for studies published between January 2000 to January 2020 were searched and a systematic review was conducted using the Cochrane Framework. Primary studies were screened for inclusion and a critical appraisal performed. Data was analysed and frequency tables were used to summarise the data followed by a narrative synthesis. Results A total of 9708 adverse events had been recorded on VigiAccess of which 6054 were not recorded on the PIL and the FDA approval document. Most of the reports were received from the Americas and were for adult women aged 45-64 years (24%, n=1059). The highest number of adverse events reported were for psychiatric events (19%; n=1889), followed by gastrointestinal effects (18%; n=1839). Specific psychiatric disorders recorded included anxiety (316), depression (208), hallucination (168) and agitation (142). The systematic review confirmed several psychiatric adverse effects associated with the use of vilazodone. The findings of this study suggested that these common psychiatric adverse effects associated with the use of vilazodone were not known during the time of FDA approval of the drug and is not currently recorded in the patient information leaflet (PIL). Conclusions In summary, this study found several adverse drug reactions not recorded in documents emanating from clinical trials pre-marketing. This highlights the importance of continued postmarketing surveillance of a drug, as well as the need for further studies on the psychiatric adverse events associated with vilazodone in order to improve the safety profile. Advisors/Committee Members: Oosthuizen, Frasia. (advisor), Mensah, Kofi Boama. (advisor).

Subjects/Keywords: Vilazodone - adverse drug reactions.; Major depressive disorder - adverse drug reactions.; Antidepressants - adverse drug reactions.; Antidepressants - post-marketing surveillance.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kaja, H. (2020). The safety profile of Vilazodone: a study on post-marketing surveillance. (Thesis). University of KwaZulu-Natal. Retrieved from https://researchspace.ukzn.ac.za/handle/10413/19010

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kaja, Humraaz. “The safety profile of Vilazodone: a study on post-marketing surveillance.” 2020. Thesis, University of KwaZulu-Natal. Accessed February 27, 2021. https://researchspace.ukzn.ac.za/handle/10413/19010.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kaja, Humraaz. “The safety profile of Vilazodone: a study on post-marketing surveillance.” 2020. Web. 27 Feb 2021.

Vancouver:

Kaja H. The safety profile of Vilazodone: a study on post-marketing surveillance. [Internet] [Thesis]. University of KwaZulu-Natal; 2020. [cited 2021 Feb 27]. Available from: https://researchspace.ukzn.ac.za/handle/10413/19010.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kaja H. The safety profile of Vilazodone: a study on post-marketing surveillance. [Thesis]. University of KwaZulu-Natal; 2020. Available from: https://researchspace.ukzn.ac.za/handle/10413/19010

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

29. Luciana Kelly Ximenes dos Santos. Estudo dos efeitos comportamentais e neuroquÃmicos do monoterpeno acetato de citronelila em camundongos.

Degree: PhD, 2014, Universidade Federal do Ceará

URL: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=13914 ;

►

O acetato de citronelila Ã um monoterpeno presente no Ãleo essencial de diversas plantas como a citronela. Estudos mostraram sua atividade como substÃncia anti-inflamatÃria, antioxidante,… (more)

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O acetato de citronelila Ã um monoterpeno presente no Ãleo essencial de diversas plantas como a citronela. Estudos mostraram sua atividade como substÃncia anti-inflamatÃria, antioxidante, antimicrobiana e analgÃsica, sendo seu maior uso, na veterinÃria como repelente para insetos. Entretanto, pesquisas que mostrem sua atividade como antidepressivo e ansiolÃtico em modelos experimentais, nÃo foram realizadas. O presente estudo investigou a atividade antidepressiva em camundongos nos testes experimentais do nado forÃado e teste de suspensÃo da cauda, bem como o envolvimento do sistema monoaminÃrgico nestes efeitos. A anÃlise neuroquÃmica a fim de verificar a atividade antioxidante nos camundongos submetidos ao teste do nado forÃado tambÃm foi realizado. AlÃm disso, foi verificada tambÃm a atividade ansiolÃtica, no teste do plus maze, a avaliaÃÃo da atividade motora no teste do campo aberto, a atividade anticonvulsivante no teste das convulsÃes induzidas por pentilenotetrazol, e a atividade hipnÃtica no tempo de sono induzido por pentobarbital. A toxicologia e o dano aos ÃrgÃos (cÃrebro, fÃgado e rim) dos animais tambÃm foi avaliada. O acetato de citronelila reduziu o tempo de imobilidade no teste do nado forÃado e no teste de suspensÃo da cauda, nas doses de 50 e 100 mg/kg, v.o. O efeito de anti-imobilidade do acetato de citronelila (50 e 100 mg/kg) foi revertido pelo prÃ-tratamento com PCPA 100 mg/kg i.p. (inibidor da sÃntese de serotonina), Prazosin 1mg/kg, i.p. (antagonista α-1 adrenÃrgico), ioimbina 1mg/kg, i.p. (antagonista α-2 adrenÃrgico), SCH23390, 15 Âg/kg, s.c. (antagonista dopaminÃrgico D1) ou sulpirida 50 mg/kg, i.p. (antagonista dopaminÃrgico D2). O acetato de citronelila nÃo alterou a atividade locomotora espontÃnea dos animais no teste do campo aberto, bem como nÃo apresentou atividade ansiolÃtica nos animais, no teste do plus maze. A anÃlise dos nÃveis de monoaminas mostrou que houve um aumento dos nÃveis das monoaminas (NA, DA e 5-HT) na dose de 100 mg/kg do acetato de citronelila e que a dose de 50 mg/kg aumentou os nÃveis de NA no corpo estriado dos camundongos. Houve uma diminuiÃÃo nos nÃveis de metabÃlitos (DOPAC, HVA e 5-HIAA) no corpo estriado dos camundongos. Os testes de toxicidade mostraram que o acetato de citronelila apresentou um nÃvel de seguranÃa 5 (CINCO), de acordo com o protocolo OECD 423 e mostrou que nÃo houve alteraÃÃes histolÃgicas significativas nos ÃrgÃos dos animais estudados. Com isso, o estudo sugere que o efeito de anti-imobilidade do acetato de citronelila no teste do nado forÃado estÃ relacionado com sua aÃÃo nos receptores adrenÃrgicos, dopaminÃrgicos e serotonÃrgicos, o qual foi evidenciado por um aumento nos nÃveis de monoaminas no cÃrebro, sugerindo um possÃvel efeito antidepressivo desta substÃncia. NÃo houve alteraÃÃo da atividade locomotora dos animais, bem como evidÃncia de efeitos ansiolÃticos no teste do plus maze, alÃm de, nÃo apresentar efeitos toxicolÃgicos significativos.

The citronellyl acetate is a monoterpene present in the essential oil of…

Advisors/Committee Members: Marta Maria de FranÃa Fonteles, Edna Maria Camelo Chaves, CÃcero Francisco Bezerra Felipe, Jeferson FalcÃo do Amaral, Francisca ClÃa FlorenÃo de Sousa.

Subjects/Keywords: FARMACOLOGIA; Antidepressivos; Monoaminas BiogÃnicas; Cymbopogon; Antidepressants; Monoamines Biogenics; Cymbopogon

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Santos, L. K. X. d. (2014). Estudo dos efeitos comportamentais e neuroquÃmicos do monoterpeno acetato de citronelila em camundongos. (Doctoral Dissertation). Universidade Federal do Ceará. Retrieved from http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=13914 ;

Chicago Manual of Style (16^th Edition):

Santos, Luciana Kelly Ximenes dos. “Estudo dos efeitos comportamentais e neuroquÃmicos do monoterpeno acetato de citronelila em camundongos.” 2014. Doctoral Dissertation, Universidade Federal do Ceará. Accessed February 27, 2021. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=13914 ;.

MLA Handbook (7^th Edition):

Santos, Luciana Kelly Ximenes dos. “Estudo dos efeitos comportamentais e neuroquÃmicos do monoterpeno acetato de citronelila em camundongos.” 2014. Web. 27 Feb 2021.

Vancouver:

Santos LKXd. Estudo dos efeitos comportamentais e neuroquÃmicos do monoterpeno acetato de citronelila em camundongos. [Internet] [Doctoral dissertation]. Universidade Federal do Ceará 2014. [cited 2021 Feb 27]. Available from: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=13914 ;.

Council of Science Editors:

Santos LKXd. Estudo dos efeitos comportamentais e neuroquÃmicos do monoterpeno acetato de citronelila em camundongos. [Doctoral Dissertation]. Universidade Federal do Ceará 2014. Available from: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=13914 ;

University of Rochester

30. Herr, Megan. Antidepressant Use and Risk of Central Nervous System Metastasis.

Degree: PhD, 2016, University of Rochester

URL: http://hdl.handle.net/1802/30505

► Central nervous system (CNS) metastasis is the spread of a primary cancer to the CNS and occurs in up to 25% of cancer patients. Antidepressant… (more)

▼ Central nervous system (CNS) metastasis is the spread of a primary cancer to the CNS and occurs in up to 25% of cancer patients. Antidepressant therapy, used in 15-30% of cancer patients, affects the blood-brain barrier, potentially allowing CNS metastasis. One study found selective serotonin reuptake inhibitors (SSRIs), a class of antidepressants, increased CNS metastasis in mice. Our study determined whether antidepressants, and specifically SSRIs, increased the relative odds of CNS metastasis. Using a case-control study design, subjects were identified from the three types of cancers with the highest cumulative incidence of CNS metastasis (excluding lung cancer) at our institution: breast cancer, melanoma, and lymphoma. Our case ascertainment rate was 27.6% resulting in 189 cases (patients with CNS metastasis) and 945 controls (patients without CNS metastasis). Using logistic regression models (Aim 1), we separately estimated the relative odds of CNS metastasis associated with ‘any antidepressant use’ (any antidepressant irrespective of class), ‘any SSRI use’ (SSRI use, nonexclusively), and ‘exclusive SSRI use’ (only SSRI use and no other class of antidepressant), all compared to ‘no antidepressant use’. Using linear regression and only breast cancer controls, we separately estimated the change in white blood cell (WBC) count associated with ‘any antidepressant use’ and ‘any SSRI use’ (Aim 2). Although not statistically significant, the odds of CNS metastasis in breast cancer associated with ‘any SSRI use’ (Aim 1) was greater than 1.0 (OR=1.73, 95% CI = 0.75, 4.04). However, the smaller than expected sample size may, in part, explain the lack of statistical significance. In Aim 2, WBC counts of those breast cancer controls who took SSRIs were 0.75 x 109/L higher than those breast cancer controls who did not take antidepressants (95% CI = 0.01, 1.45). This was the first study to examine the association between antidepressant use and CNS metastasis. Our results found no clear statistically significant associations but suggested an increase in CNS metastasis and WBC count associated with antidepressant use. However, these estimates were imprecise with wide confidence intervals. Future studies, with larger sample sizes, are needed to examine these associations, and perhaps focus specifically on breast cancer patients.

Subjects/Keywords: Central nervous system metastasis; CNS metastasis; antidepressants; SSRIs; inflammation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Herr, M. (2016). Antidepressant Use and Risk of Central Nervous System Metastasis. (Doctoral Dissertation). University of Rochester. Retrieved from http://hdl.handle.net/1802/30505

Chicago Manual of Style (16^th Edition):

Herr, Megan. “Antidepressant Use and Risk of Central Nervous System Metastasis.” 2016. Doctoral Dissertation, University of Rochester. Accessed February 27, 2021. http://hdl.handle.net/1802/30505.

MLA Handbook (7^th Edition):

Herr, Megan. “Antidepressant Use and Risk of Central Nervous System Metastasis.” 2016. Web. 27 Feb 2021.

Vancouver:

Herr M. Antidepressant Use and Risk of Central Nervous System Metastasis. [Internet] [Doctoral dissertation]. University of Rochester; 2016. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/1802/30505.

Council of Science Editors:

Herr M. Antidepressant Use and Risk of Central Nervous System Metastasis. [Doctoral Dissertation]. University of Rochester; 2016. Available from: http://hdl.handle.net/1802/30505

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