subject:(antidepressants)

King's College London (University of London)

1. Hodgson, Karen. Biomarkers of antidepressant treatment outcomes.

Degree: PhD, 2015, King's College London (University of London)

URL: http://kclpure.kcl.ac.uk/portal/en/theses/biomarkers-of-antidepressant-treatment-outcomes(dcd101e2-4f7b-423c-8354-29c3d827fd91).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.634169

► Whilst antidepressants are widely prescribed, there is a large degree of variation between patients in terms of treatment outcomes. Furthermore, the mechanisms by which these… (more)

▼ Whilst antidepressants are widely prescribed, there is a large degree of variation between patients in terms of treatment outcomes. Furthermore, the mechanisms by which these drugs exert their effects remain unclear. In this thesis, genetic biomarkers of antidepressant outcomes have been explored, in order to better understand the molecular mechanisms underpinning effective antidepressant treatment. The research presented here use data from the GENDEP project, which is a large pharmacogenetic study of depressed patients receiving antidepressant treatment. Firstly, the pharmacological underpinnings of antidepressant-associated side effects were used to categorise these side effects and conduct a candidate gene analysis. Whilst a significant association between variation within the HTR2C gene and serotonergic side effects was found, the observation was not replicated in a second sample. Secondly, the role of variability in drug metabolism rates in treatment outcomes was investigated. Examining genotypic information on the cytochrome P450 enzymes, no associations with treatment response, side effects or study discontinuation were observed. Furthermore, serum concentrations of antidepressant were unrelated to treatment response or overall burden of side effects, predicting only a minority of specific side effects. Thirdly, transcriptomic changes with drug administration were explored in relation to treatment efficacy. Two genes were identified where changes in expression levels were significantly associated with treatment response amongst patients taking nortriptyline. Furthermore, using a network-based approach, changes in gene expression across one module of coexpressed genes showed significant correlation with symptom improvement; this biological network generalised across different antidepressant medications. Finally, genomic and transcriptomic data were combined, in an examination of the genetic control of gene expression. This analysis then was used to gain an insight into the molecular processes that link genotype to phenotype. The evidence presented within this thesis, when considered in combination with existing literature, highlights that antidepressant efficacy is a complex trait, influenced by many genes of small effect. Nevertheless, by layering together different levels of information, we can begin to dissect the molecular mechanisms involved in antidepressant action.

Subjects/Keywords: Pharmacogenetics; Antidepressants; Transcriptomics; Depression

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APA (6^th Edition):

Hodgson, K. (2015). Biomarkers of antidepressant treatment outcomes. (Doctoral Dissertation). King's College London (University of London). Retrieved from http://kclpure.kcl.ac.uk/portal/en/theses/biomarkers-of-antidepressant-treatment-outcomes(dcd101e2-4f7b-423c-8354-29c3d827fd91).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.634169

Chicago Manual of Style (16^th Edition):

Hodgson, Karen. “Biomarkers of antidepressant treatment outcomes.” 2015. Doctoral Dissertation, King's College London (University of London). Accessed October 19, 2019. http://kclpure.kcl.ac.uk/portal/en/theses/biomarkers-of-antidepressant-treatment-outcomes(dcd101e2-4f7b-423c-8354-29c3d827fd91).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.634169.

MLA Handbook (7^th Edition):

Hodgson, Karen. “Biomarkers of antidepressant treatment outcomes.” 2015. Web. 19 Oct 2019.

Vancouver:

Hodgson K. Biomarkers of antidepressant treatment outcomes. [Internet] [Doctoral dissertation]. King's College London (University of London); 2015. [cited 2019 Oct 19]. Available from: http://kclpure.kcl.ac.uk/portal/en/theses/biomarkers-of-antidepressant-treatment-outcomes(dcd101e2-4f7b-423c-8354-29c3d827fd91).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.634169.

Council of Science Editors:

Hodgson K. Biomarkers of antidepressant treatment outcomes. [Doctoral Dissertation]. King's College London (University of London); 2015. Available from: http://kclpure.kcl.ac.uk/portal/en/theses/biomarkers-of-antidepressant-treatment-outcomes(dcd101e2-4f7b-423c-8354-29c3d827fd91).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.634169

University of Alberta

2. Aspeslet, Launa J. Chirality and metabolism: studies on the antidepressants rac-tranylcypromine and rac-fluoxetine.

Degree: PhD, Faculty of Medicine Faculty of Pharmacy and Pharmaceutical Sciences, 1994, University of Alberta

URL: https://era.library.ualberta.ca/files/qv33s018k

Subjects/Keywords: Antidepressants – Metabolism.

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APA (6^th Edition):

Aspeslet, L. J. (1994). Chirality and metabolism: studies on the antidepressants rac-tranylcypromine and rac-fluoxetine. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/qv33s018k

Chicago Manual of Style (16^th Edition):

Aspeslet, Launa J. “Chirality and metabolism: studies on the antidepressants rac-tranylcypromine and rac-fluoxetine.” 1994. Doctoral Dissertation, University of Alberta. Accessed October 19, 2019. https://era.library.ualberta.ca/files/qv33s018k.

MLA Handbook (7^th Edition):

Aspeslet, Launa J. “Chirality and metabolism: studies on the antidepressants rac-tranylcypromine and rac-fluoxetine.” 1994. Web. 19 Oct 2019.

Vancouver:

Aspeslet LJ. Chirality and metabolism: studies on the antidepressants rac-tranylcypromine and rac-fluoxetine. [Internet] [Doctoral dissertation]. University of Alberta; 1994. [cited 2019 Oct 19]. Available from: https://era.library.ualberta.ca/files/qv33s018k.

Council of Science Editors:

Aspeslet LJ. Chirality and metabolism: studies on the antidepressants rac-tranylcypromine and rac-fluoxetine. [Doctoral Dissertation]. University of Alberta; 1994. Available from: https://era.library.ualberta.ca/files/qv33s018k

University of Alberta

3. Paetsch, Paul R. 2-phenylethylamine: possible role in antidepressant drug action.

Degree: PhD, Department of Medicine, 1992, University of Alberta

URL: https://era.library.ualberta.ca/files/5138jg73t

Subjects/Keywords: Antidepressants.; Phenethylamines.

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APA (6^th Edition):

Paetsch, P. R. (1992). 2-phenylethylamine: possible role in antidepressant drug action. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/5138jg73t

Chicago Manual of Style (16^th Edition):

Paetsch, Paul R. “2-phenylethylamine: possible role in antidepressant drug action.” 1992. Doctoral Dissertation, University of Alberta. Accessed October 19, 2019. https://era.library.ualberta.ca/files/5138jg73t.

MLA Handbook (7^th Edition):

Paetsch, Paul R. “2-phenylethylamine: possible role in antidepressant drug action.” 1992. Web. 19 Oct 2019.

Vancouver:

Paetsch PR. 2-phenylethylamine: possible role in antidepressant drug action. [Internet] [Doctoral dissertation]. University of Alberta; 1992. [cited 2019 Oct 19]. Available from: https://era.library.ualberta.ca/files/5138jg73t.

Council of Science Editors:

Paetsch PR. 2-phenylethylamine: possible role in antidepressant drug action. [Doctoral Dissertation]. University of Alberta; 1992. Available from: https://era.library.ualberta.ca/files/5138jg73t

University of Alberta

4. Dhami, Kamaldeep S. The effects of antidepressants on the phenotype of activated microglia and ischemia-injured cortical neurons.

Degree: PhD, Centre for Neuroscience, 2013, University of Alberta

URL: https://era.library.ualberta.ca/files/5x21tf82p

► Depression is one of the most common disorders appearing following a stroke and is also a major factor limiting recovery and rehabilitation in stroke patients.… (more)

▼ Depression is one of the most common disorders appearing following a stroke and is also a major factor limiting recovery and rehabilitation in stroke patients. Several antidepressants have shown to have anti-inflammatory properties within the central nervous system (CNS). The major source of pro-inflammatory factors within the CNS is from activated microglia, the innate immune cells of the CNS. Antidepressants have been shown to promote midbrain and hippocampal neuronal survival following an ischemic insult and these effects are mediated through the anti-inflammatory effects on microglia, but the effects on cortical neuronal survival after this insult have yet to be investigated. The present study aimed to test and compare antidepressants from three distinct classes (tricylics, monoamine oxidase inhibitors, and selective serotonin reuptake inhibitors [SSRIs]) on the release of inflammatory factors and amino acids from activated microglia and to determine whether altering this release could affect cortical neuronal viability after an ischemic insult. Primary microglia were treated with 1 μg/ml LPS and/or 10 μM antidepressants, and the various factors released into the medium were assayed. Co-cultures consisting of microglia and primary cortical neurons were used to assess the effects of antidepressant-treated activated microglia on the viability of ischemia-injured neurons. Of the antidepressants tested, most decreased the release of the pro-inflammatory factors nitric oxide, tumor necrosis factor-alpha, and interleukin 1- beta from activated microglia. Fluoxetine and citalopram, the SSRIs, also decreased the release of the amino acids glutamate and D-serine from LPS-activated microglia. Injured cortical neurons co-cultured with LPS-activated microglia pre-treated with fluoxetine and citalopram showed greater survival compared to injured neurons co-cultured with untreated activated microglia. Studies using NMDA receptor antagonists demonstrated that the release of glutamate and D-serine from microglia was a principal factor mediating cortical neuronal survival. In addition, we found that one possible mechanism behind the attenuation of microglial glutamate and D-serine release following fluoxetine treatment is through the induction of microglial apoptosis. Our results demonstrated for the first time that fluoxetine and citalopram decrease the release of glutamate and D- serine from LPS-activated microglia and this increases the survival of injured cortical neurons after co-culture. Fluoxetine was also shown to induce the apoptotic death of microglia.

Subjects/Keywords: Inflammation; Microglia; Excitotoxicity; Ischemia; Antidepressants

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APA (6^th Edition):

Dhami, K. S. (2013). The effects of antidepressants on the phenotype of activated microglia and ischemia-injured cortical neurons. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/5x21tf82p

Chicago Manual of Style (16^th Edition):

Dhami, Kamaldeep S. “The effects of antidepressants on the phenotype of activated microglia and ischemia-injured cortical neurons.” 2013. Doctoral Dissertation, University of Alberta. Accessed October 19, 2019. https://era.library.ualberta.ca/files/5x21tf82p.

MLA Handbook (7^th Edition):

Dhami, Kamaldeep S. “The effects of antidepressants on the phenotype of activated microglia and ischemia-injured cortical neurons.” 2013. Web. 19 Oct 2019.

Vancouver:

Dhami KS. The effects of antidepressants on the phenotype of activated microglia and ischemia-injured cortical neurons. [Internet] [Doctoral dissertation]. University of Alberta; 2013. [cited 2019 Oct 19]. Available from: https://era.library.ualberta.ca/files/5x21tf82p.

Council of Science Editors:

Dhami KS. The effects of antidepressants on the phenotype of activated microglia and ischemia-injured cortical neurons. [Doctoral Dissertation]. University of Alberta; 2013. Available from: https://era.library.ualberta.ca/files/5x21tf82p

Rhodes University

5. Steiner, Claire. An investigation into the possible neuroprotective role of antidepressant drugs.

Degree: MS, Faculty of Pharmacy, Pharmacy, 2002, Rhodes University

URL: http://hdl.handle.net/10962/d1003270

► Antidepressants are widely used in the treatment of depressive illnesses associated with neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease and Huntington’s disease. Neuroprotection in… (more)

▼ Antidepressants are widely used in the treatment of depressive illnesses associated with neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease and Huntington’s disease. Neuroprotection in such disorders is of vital importance in order to delay the progression of the primary disorder. The pathology of neurodegeneration is not fully understood. It is however widely accepted that oxidative stress and excitotoxicity play a major role. Brain tissue is rich in phospholipids, which are especially prone to oxidation due to the high level of oxygen utilization in the brain. In addition, the brain lacks defence mechanisms to protect it against the wrath of free radicals. Presently, there is a wide variety of antidepressant drugs available. These range from the original tricyclic antidepressants to the newer selective serotonin reuptake inhibitors. It is not known whether antidepressant drugs, old or new, offer neuroprotection or how the existing state and/or the progression of neurodegeneration, is influenced by these agents. The present study was undertaken to determine how nortriptyline, trimipramine and fluoxetine affect neurodegeneration. Initial in vitro and in vivo studies show that all three of the antidepressants (0-1mM) studied provide neuroprotection from quinolinic acid induced lipid peroxidation. A histological investigation supported these findings by showing that a marginal degree of neuroprotection is apparent when treating animals with antidepressants (10mg/kg) before and following quinolinic acid intrastriatal injection. Further studies were undertaken in an attempt to determine the mode of neuroprotective action of the agents studied. An in vitro study of superoxide anion induced lipid peroxidation indicates that these agents do not act as antioxidants. The influence of the antidepressants on tryptophan 2,3-dioxygenase activity was assessed, based on the understanding that inhibition of this enzyme results in increased levels of the known antioxidant indoleamine, melatonin. Nortriptyline hydrochloride is seen to inhibit tryptophan 2,3-dioxygenase activity and as such it is possible that this antidepressant can indirectly provide neuroprotection by increasing available melatonin. Electrochemical and UV/visible studies show that trimipramine maleate interacts with free iron (II) and iron (III) ions. Free metal ions can catalyse the formation of damaging free radicals. Through interaction with trimipramine maleate, these ions will be unavailable to the system and thus cannot contribute to oxidative stress. The findings of this study indicate that antidepressants may be able to provide neuroprotection to neuronal cells. The mode of such neuroprotective actions need to be further examined so that patients suffering from depression coexisting with neurodegenerative diseases can be safely and effectively treated. Advisors/Committee Members: Daya, Santy.

Subjects/Keywords: Antidepressants – Research

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APA (6^th Edition):

Steiner, C. (2002). An investigation into the possible neuroprotective role of antidepressant drugs. (Masters Thesis). Rhodes University. Retrieved from http://hdl.handle.net/10962/d1003270

Chicago Manual of Style (16^th Edition):

Steiner, Claire. “An investigation into the possible neuroprotective role of antidepressant drugs.” 2002. Masters Thesis, Rhodes University. Accessed October 19, 2019. http://hdl.handle.net/10962/d1003270.

MLA Handbook (7^th Edition):

Steiner, Claire. “An investigation into the possible neuroprotective role of antidepressant drugs.” 2002. Web. 19 Oct 2019.

Vancouver:

Steiner C. An investigation into the possible neuroprotective role of antidepressant drugs. [Internet] [Masters thesis]. Rhodes University; 2002. [cited 2019 Oct 19]. Available from: http://hdl.handle.net/10962/d1003270.

Council of Science Editors:

Steiner C. An investigation into the possible neuroprotective role of antidepressant drugs. [Masters Thesis]. Rhodes University; 2002. Available from: http://hdl.handle.net/10962/d1003270

Rhodes University

6. Skene, Debra Jean. The evaluation of melatonin as a possible antidepressive.

Degree: Faculty of Pharmacy, Pharmacy, 1980, Rhodes University

URL: http://hdl.handle.net/10962/d1001465

► Melatonin, a hormone of the pineal gland, was evaluated in a variety of animal models of depression. Measurements of the frog righting reflex and rat… (more)

Subjects/Keywords: Melatonin; Antidepressants

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Skene, D. J. (1980). The evaluation of melatonin as a possible antidepressive. (Thesis). Rhodes University. Retrieved from http://hdl.handle.net/10962/d1001465

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Skene, Debra Jean. “The evaluation of melatonin as a possible antidepressive.” 1980. Thesis, Rhodes University. Accessed October 19, 2019. http://hdl.handle.net/10962/d1001465.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Skene, Debra Jean. “The evaluation of melatonin as a possible antidepressive.” 1980. Web. 19 Oct 2019.

Vancouver:

Skene DJ. The evaluation of melatonin as a possible antidepressive. [Internet] [Thesis]. Rhodes University; 1980. [cited 2019 Oct 19]. Available from: http://hdl.handle.net/10962/d1001465.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Skene DJ. The evaluation of melatonin as a possible antidepressive. [Thesis]. Rhodes University; 1980. Available from: http://hdl.handle.net/10962/d1001465

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Michigan State University

7. Vrbanac, John James. Neuropsychopharmacological investigations with 4H-3-methylcarboxamide-3,4-benzoxazine-2-one : demonstration of a novel spectrum of central activity.

Degree: MS, Department of Pharmacology, 1978, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:37698

Subjects/Keywords: Antidepressants; Neuropsychopharmacology

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APA (6^th Edition):

Vrbanac, J. J. (1978). Neuropsychopharmacological investigations with 4H-3-methylcarboxamide-3,4-benzoxazine-2-one : demonstration of a novel spectrum of central activity. (Masters Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:37698

Chicago Manual of Style (16^th Edition):

Vrbanac, John James. “Neuropsychopharmacological investigations with 4H-3-methylcarboxamide-3,4-benzoxazine-2-one : demonstration of a novel spectrum of central activity.” 1978. Masters Thesis, Michigan State University. Accessed October 19, 2019. http://etd.lib.msu.edu/islandora/object/etd:37698.

MLA Handbook (7^th Edition):

Vrbanac, John James. “Neuropsychopharmacological investigations with 4H-3-methylcarboxamide-3,4-benzoxazine-2-one : demonstration of a novel spectrum of central activity.” 1978. Web. 19 Oct 2019.

Vancouver:

Vrbanac JJ. Neuropsychopharmacological investigations with 4H-3-methylcarboxamide-3,4-benzoxazine-2-one : demonstration of a novel spectrum of central activity. [Internet] [Masters thesis]. Michigan State University; 1978. [cited 2019 Oct 19]. Available from: http://etd.lib.msu.edu/islandora/object/etd:37698.

Council of Science Editors:

Vrbanac JJ. Neuropsychopharmacological investigations with 4H-3-methylcarboxamide-3,4-benzoxazine-2-one : demonstration of a novel spectrum of central activity. [Masters Thesis]. Michigan State University; 1978. Available from: http://etd.lib.msu.edu/islandora/object/etd:37698

McGill University

8. Cuffe, Jennifer. A rhetorical tale : neurochemistry and the efficacies of antidepressants in Canada.

Degree: MA, Department of Anthropology., 2002, McGill University

URL: http://digitool.library.mcgill.ca/thesisfile79756.pdf

► Recent work in anthropology has speculated on how developments in molecular biology and medicine might bring about new bodies, selves, and forms of sociality. This… (more)

Subjects/Keywords: Antidepressants – Canada; Antidepressants – Social aspects

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APA (6^th Edition):

Cuffe, J. (2002). A rhetorical tale : neurochemistry and the efficacies of antidepressants in Canada. (Masters Thesis). McGill University. Retrieved from http://digitool.library.mcgill.ca/thesisfile79756.pdf

Chicago Manual of Style (16^th Edition):

Cuffe, Jennifer. “A rhetorical tale : neurochemistry and the efficacies of antidepressants in Canada.” 2002. Masters Thesis, McGill University. Accessed October 19, 2019. http://digitool.library.mcgill.ca/thesisfile79756.pdf.

MLA Handbook (7^th Edition):

Cuffe, Jennifer. “A rhetorical tale : neurochemistry and the efficacies of antidepressants in Canada.” 2002. Web. 19 Oct 2019.

Vancouver:

Cuffe J. A rhetorical tale : neurochemistry and the efficacies of antidepressants in Canada. [Internet] [Masters thesis]. McGill University; 2002. [cited 2019 Oct 19]. Available from: http://digitool.library.mcgill.ca/thesisfile79756.pdf.

Council of Science Editors:

Cuffe J. A rhetorical tale : neurochemistry and the efficacies of antidepressants in Canada. [Masters Thesis]. McGill University; 2002. Available from: http://digitool.library.mcgill.ca/thesisfile79756.pdf

University of Arizona

9. Hintermeister, Nalukui Mwisiya. SYNTHESIS AND NMR STUDIES OF PERI-SUBSTITUTED PROMAZINE AND IMIPRAMINE ANALOGUES.

Degree: 1984, University of Arizona

URL: http://hdl.handle.net/10150/275000

Subjects/Keywords: Antidepressants.; Antidepressants – Spectra.; Imipramine.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hintermeister, N. M. (1984). SYNTHESIS AND NMR STUDIES OF PERI-SUBSTITUTED PROMAZINE AND IMIPRAMINE ANALOGUES. (Masters Thesis). University of Arizona. Retrieved from http://hdl.handle.net/10150/275000

Chicago Manual of Style (16^th Edition):

Hintermeister, Nalukui Mwisiya. “SYNTHESIS AND NMR STUDIES OF PERI-SUBSTITUTED PROMAZINE AND IMIPRAMINE ANALOGUES. ” 1984. Masters Thesis, University of Arizona. Accessed October 19, 2019. http://hdl.handle.net/10150/275000.

MLA Handbook (7^th Edition):

Hintermeister, Nalukui Mwisiya. “SYNTHESIS AND NMR STUDIES OF PERI-SUBSTITUTED PROMAZINE AND IMIPRAMINE ANALOGUES. ” 1984. Web. 19 Oct 2019.

Vancouver:

Hintermeister NM. SYNTHESIS AND NMR STUDIES OF PERI-SUBSTITUTED PROMAZINE AND IMIPRAMINE ANALOGUES. [Internet] [Masters thesis]. University of Arizona; 1984. [cited 2019 Oct 19]. Available from: http://hdl.handle.net/10150/275000.

Council of Science Editors:

Hintermeister NM. SYNTHESIS AND NMR STUDIES OF PERI-SUBSTITUTED PROMAZINE AND IMIPRAMINE ANALOGUES. [Masters Thesis]. University of Arizona; 1984. Available from: http://hdl.handle.net/10150/275000

10. Seguini, Mara. Analysis of miRNome expression profile in hippocampus of rats treated with antidepressants.

Degree: 2015, Università degli Studi di Catania

URL: http://hdl.handle.net/10761/1708

► MicroRNAs (miRNAs) are small, non-coding RNAs with a key role in regulating gene expression at post-transcriptional level. Recent investigations suggested that dysregulation in miRNA expression… (more)

▼ MicroRNAs (miRNAs) are small, non-coding RNAs with a key role in regulating gene expression at post-transcriptional level. Recent investigations suggested that dysregulation in miRNA expression may be critical for mental disorders pathophysiology, including mood disorders, and in psychotropic drugs action, such as mood stabilizers and antidepressants (ADs). Aim of the studies presented was to analyze whether modulation of hippocampal miRNome could be part of the mode of action of different ADs, fluoxetine, desipramine and agomelatine. Moreover, in order to assess the time course of ADs effects, treatments were performed for various time lengths (3,7 or 21 days). Rat hippocampal miRNome expression was investigated by means of TaqMan Rodent MicroRNA Arrays. We found that all ADs induced a significant modulation of hippocampal miRNome, although with different time-dependent effects. Indeed, all ADs significant modulated miRNA expression already after 3 days of treatment with the most pronounced effect by agomelatine (37 miRNAs, mainly down-regulated); whereas both fluoxetine and desipramine modified the expression of 8 different miRNAs. After 7 days, the greater number of miRNAs was modulated by fluoxetine (35 miRNAs, mainly up-regulated), while desipramine and agomelatine modulated the expression of 13 and 22 miRNAs, respectively. Finally, 21 days of agomelatine treatment modulated the expression of 6 miRNAs. Interestingly, some of the miRNAs were found to be similarly affected by at least two of the different ADs. A bio-informatic analysis allowed the identification of putative miRNA targets and signalling pathways modulated by the identified miRNAs. The predicted target genes of miRNAs are involved in several pathways related to neuronal functions and ADs mechanism of action; moreover, many of the putative target genes, in particular those of miRs modulated by agomelatine, are enriched in pathways related to DNA/RNA regulation and epigenetic mechanisms. A number of putative miRNA target genes have been selected for validation studies by means of mRNA/protein expression analyses. The results of these work, showing that AD treatments induce early and time-dependent modifications in the expression of hippocampal miRNAs, could be of help to better clarify the ADs mechanism of action and to identify new putative targets for the development of novel drugs with greater efficacy and a more rapid onset of action.

Subjects/Keywords: Area 06 - Scienze mediche; miRNOme, hippocampus, antidepressants

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APA (6^th Edition):

Seguini, M. (2015). Analysis of miRNome expression profile in hippocampus of rats treated with antidepressants. (Thesis). Università degli Studi di Catania. Retrieved from http://hdl.handle.net/10761/1708

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Seguini, Mara. “Analysis of miRNome expression profile in hippocampus of rats treated with antidepressants.” 2015. Thesis, Università degli Studi di Catania. Accessed October 19, 2019. http://hdl.handle.net/10761/1708.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Seguini, Mara. “Analysis of miRNome expression profile in hippocampus of rats treated with antidepressants.” 2015. Web. 19 Oct 2019.

Vancouver:

Seguini M. Analysis of miRNome expression profile in hippocampus of rats treated with antidepressants. [Internet] [Thesis]. Università degli Studi di Catania; 2015. [cited 2019 Oct 19]. Available from: http://hdl.handle.net/10761/1708.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Seguini M. Analysis of miRNome expression profile in hippocampus of rats treated with antidepressants. [Thesis]. Università degli Studi di Catania; 2015. Available from: http://hdl.handle.net/10761/1708

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

11. Carla Maria Maia Garcias. PREVALÊNCIA E FATORES ASSOCIADOS AO USO DE ANTIDEPRESSIVOS EM UMA POPULAÇÃO DE ÁREA URBANA.

Degree: 2006, Universidade Catolica de Pelotas

URL: http://biblioteca.ucpel.tche.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=121

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Objetivo: Determinar a prevalência e fatores associados ao uso de antidepressivos em adultos residentes em uma área urbana. Métodos: Estudo transversal em uma amostra representativa… (more)

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Objetivo: Determinar a prevalência e fatores associados ao uso de antidepressivos em adultos residentes em uma área urbana. Métodos: Estudo transversal em uma amostra representativa de adultos com idade igual ou superior a 40 anos, moradores na zona urbana de Pelotas, Estado do Rio Grande do Sul. Os dados foram coletados por meio de um questionário padronizado e pré-codificado. Foi definido como usuário de antidepressivo o adulto que relatou ter usado medicação antidepressiva nos últimos quinze dias. Variáveis sóciodemográficas e comportamentais foram avaliadas. Para as comparações entre proporções, utilizou-se o teste de qui-quadrado e, para a análise multivariada, a regressão logística não condicional. Resultados: Foram entrevistados 1327 adultos, dos quais 9,3% tinham usado antidepressivos. O maior consumo de antidepressivos associou-se significativamente ao sexo feminino, IC 95% 2,45(1,50-4,02), ao nível sócioeconômico mais elevado (classes A e B), IC 95% 2,07(1,28 -3,34), e a não estar exercendo uma atividade de trabalho, IC 95% 1,65(1,06-2,55). Os antidepressivos do grupo dos Inibidores Seletivos da Recaptação da Serotonina (ISRS) foram os mais consumidos, 60,2%. Conclusões: A prevalência de uso de antidepressivos foi superior às encontradas em outros estudos. Os determinantes individuais de utilização, poderão servir de embasamento às estratégias para diminuir o consumo de antidepressivos nesses grupos

Objectives To estimate the prevalence and determinants of antidepressants among adults living in an urban area. Methods Transversal study in a representative sample of adults at the age of 40 years or older, living in the urban area of Pelotas, State of Rio Grande do Sul, Brazil. The data was collected through a pre-codified and standardized questionnaire. Was defined as an antidepressants user, the adult that had declared the use of antidepressant medication on the last fiftenn days. Variables were valued according to the social demographic and behavior of these individuals. The chi-squared test was used for comparisons between proportions. The non conditional logistic regression was used for multivariate analysis with robust adjustment for variances. Results Were interviewed 1327 adults, which 9,3 % had used antidepressants. The major use of antidepressants were associated significantly to the feminine gender, IC 95% 2,45 (1,50-4,02), to the upper social levels, IC 95% 2,07(0,68-1,95), and also associated to jobless subjects, 1,65(1,06-2,55). The most used antidepressants were of the Serotonin inhibiters group (ISRS), in a proportion of 60,2% of the interviewed subjects. Conclusions The prevalence of antidepressants use was superior to the ones found in other studies. These studied groups and a base to a better strategic therapy that can be elaborated to decrease the use of antidepressants in these groups Objectives To estimate the prevalence and determinants of antidepressants among adults living in an urban area. Methods Transversal study in a representative sample of adults at the age of 40 years or…

Advisors/Committee Members: Ricardo Tavares Pinheiro.

Subjects/Keywords: epidemiology; antidepressivos; adultos; epidemiologia.; antidepressants; adults; MEDICINA

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APA (6^th Edition):

Garcias, C. M. M. (2006). PREVALÊNCIA E FATORES ASSOCIADOS AO USO DE ANTIDEPRESSIVOS EM UMA POPULAÇÃO DE ÁREA URBANA. (Thesis). Universidade Catolica de Pelotas. Retrieved from http://biblioteca.ucpel.tche.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=121

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Garcias, Carla Maria Maia. “PREVALÊNCIA E FATORES ASSOCIADOS AO USO DE ANTIDEPRESSIVOS EM UMA POPULAÇÃO DE ÁREA URBANA.” 2006. Thesis, Universidade Catolica de Pelotas. Accessed October 19, 2019. http://biblioteca.ucpel.tche.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=121.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Garcias, Carla Maria Maia. “PREVALÊNCIA E FATORES ASSOCIADOS AO USO DE ANTIDEPRESSIVOS EM UMA POPULAÇÃO DE ÁREA URBANA.” 2006. Web. 19 Oct 2019.

Vancouver:

Garcias CMM. PREVALÊNCIA E FATORES ASSOCIADOS AO USO DE ANTIDEPRESSIVOS EM UMA POPULAÇÃO DE ÁREA URBANA. [Internet] [Thesis]. Universidade Catolica de Pelotas; 2006. [cited 2019 Oct 19]. Available from: http://biblioteca.ucpel.tche.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=121.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Garcias CMM. PREVALÊNCIA E FATORES ASSOCIADOS AO USO DE ANTIDEPRESSIVOS EM UMA POPULAÇÃO DE ÁREA URBANA. [Thesis]. Universidade Catolica de Pelotas; 2006. Available from: http://biblioteca.ucpel.tche.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=121

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Queensland University of Technology

12. Sanjida, Saira. A retrospective case-control study on the prescribing practices of antidepressants administered to cancer patients and non-cancer patients in Australia.

Degree: 2016, Queensland University of Technology

URL: http://eprints.qut.edu.au/94240/

► Comorbidity of depression risks is common among cancer patients. The pharmacological treatment of depression is antidepressants. However, antidepressants may interact with anticancer drugs or cause… (more)

Subjects/Keywords: Antidepressants; Cancer; Prescription; Psychotropic; Non-cancer

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APA (6^th Edition):

Sanjida, S. (2016). A retrospective case-control study on the prescribing practices of antidepressants administered to cancer patients and non-cancer patients in Australia. (Thesis). Queensland University of Technology. Retrieved from http://eprints.qut.edu.au/94240/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sanjida, Saira. “A retrospective case-control study on the prescribing practices of antidepressants administered to cancer patients and non-cancer patients in Australia.” 2016. Thesis, Queensland University of Technology. Accessed October 19, 2019. http://eprints.qut.edu.au/94240/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sanjida, Saira. “A retrospective case-control study on the prescribing practices of antidepressants administered to cancer patients and non-cancer patients in Australia.” 2016. Web. 19 Oct 2019.

Vancouver:

Sanjida S. A retrospective case-control study on the prescribing practices of antidepressants administered to cancer patients and non-cancer patients in Australia. [Internet] [Thesis]. Queensland University of Technology; 2016. [cited 2019 Oct 19]. Available from: http://eprints.qut.edu.au/94240/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sanjida S. A retrospective case-control study on the prescribing practices of antidepressants administered to cancer patients and non-cancer patients in Australia. [Thesis]. Queensland University of Technology; 2016. Available from: http://eprints.qut.edu.au/94240/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Central Connecticut State University

13. Colon, Analix, 1977-. Biological aspects of depression and antidepressants / Analix Colon.

Degree: Department of Biomolecular Sciences, 2003, Central Connecticut State University

URL: http://content.library.ccsu.edu/u?/ccsutheses,1506

► Depression is characterized by a mood and behavior, that can affect the ability of a person to perform daily activities and interact with others. Depression… (more)

Subjects/Keywords: Depression, Mental; Antidepressants

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APA (6^th Edition):

Colon, Analix, 1. (2003). Biological aspects of depression and antidepressants / Analix Colon. (Thesis). Central Connecticut State University. Retrieved from http://content.library.ccsu.edu/u?/ccsutheses,1506

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Colon, Analix, 1977-. “Biological aspects of depression and antidepressants / Analix Colon.” 2003. Thesis, Central Connecticut State University. Accessed October 19, 2019. http://content.library.ccsu.edu/u?/ccsutheses,1506.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Colon, Analix, 1977-. “Biological aspects of depression and antidepressants / Analix Colon.” 2003. Web. 19 Oct 2019.

Vancouver:

Colon, Analix 1. Biological aspects of depression and antidepressants / Analix Colon. [Internet] [Thesis]. Central Connecticut State University; 2003. [cited 2019 Oct 19]. Available from: http://content.library.ccsu.edu/u?/ccsutheses,1506.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Colon, Analix 1. Biological aspects of depression and antidepressants / Analix Colon. [Thesis]. Central Connecticut State University; 2003. Available from: http://content.library.ccsu.edu/u?/ccsutheses,1506

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Rhodes University

14. Kok, Eric Charl. The study of the potentiation of anticholinergic side effects of tricyclic antidepressives by female sex steroids.

Degree: Faculty of Pharmacy, Pharmacy, 1981, Rhodes University

URL: http://hdl.handle.net/10962/d1005623

► It has been recorded that women respond to tricyclic antidepressives with a greater incidence of anticholinergic side effects than men do, particularly women taking an… (more)

Subjects/Keywords: Antidepressants; Steroid hormones

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APA (6^th Edition):

Kok, E. C. (1981). The study of the potentiation of anticholinergic side effects of tricyclic antidepressives by female sex steroids. (Thesis). Rhodes University. Retrieved from http://hdl.handle.net/10962/d1005623

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kok, Eric Charl. “The study of the potentiation of anticholinergic side effects of tricyclic antidepressives by female sex steroids.” 1981. Thesis, Rhodes University. Accessed October 19, 2019. http://hdl.handle.net/10962/d1005623.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kok, Eric Charl. “The study of the potentiation of anticholinergic side effects of tricyclic antidepressives by female sex steroids.” 1981. Web. 19 Oct 2019.

Vancouver:

Kok EC. The study of the potentiation of anticholinergic side effects of tricyclic antidepressives by female sex steroids. [Internet] [Thesis]. Rhodes University; 1981. [cited 2019 Oct 19]. Available from: http://hdl.handle.net/10962/d1005623.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kok EC. The study of the potentiation of anticholinergic side effects of tricyclic antidepressives by female sex steroids. [Thesis]. Rhodes University; 1981. Available from: http://hdl.handle.net/10962/d1005623

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Otago

15. Deng, Xiaoyan. Gene Regulation by Drugs Used to Treat Mood Disorders .

Degree: 2011, University of Otago

URL: http://hdl.handle.net/10523/1806

► Mood disorders such as Major Depressive Disorder and Bipolar Disorder are devastating burdens upon sufferers, their families and society as a whole. Despite their high… (more)

▼ Mood disorders such as Major Depressive Disorder and Bipolar Disorder are devastating burdens upon sufferers, their families and society as a whole. Despite their high prevalence and socioeconomic impact, understanding the aetiology of mood disorders has proved difficult, due in part to the heterogeneity observed in disorders of mental well-being. Antidepressant and mood stabiliser drugs are the main treatment for mood disorders. Although highly efficacious, the mechanisms of action of these drugs are not well understood. This project aimed to establish the effects of such drugs on gene regulation, and in doing so, advance the field by detecting specific transcripts and biochemical pathways involved in drug response. It was anticipated that this knowledge would prove valuable for developing novel therapeutic and treatment options of the future. Initial work focused upon promoter regions of candidate genes chosen from the literature and previous results from our laboratory. Nineteen constructs were investigated in the rat serotonergic cell line RN46A, using a luciferase reporter assay and a commonly prescribed SSRI antidepressant paroxetine. Although significant differences in expression were noted between drug-exposed and control cell cultures, the system proved inconsistent, despite considerable care in experimental design and execution. A more direct approach, real-time quantitative PCR (qPCR), was then utilised to detect drug-induced gene expression differences in RN46A cells. Five drugs were used: the antidepressants paroxetine, citalopram and nortriptyline; the antipsychotic haloperidol; and the mood stabiliser sodium valproate. Of five potential reference genes for normalization of qPCR experiments, Actb, G6pd and Rnf4 were stably expressed over differing treatments. I screened thirty-nine candidate genes for expression changes attributable to drug exposure. The most striking result was a reproducible ~1700-fold up-regulation of sepiapterin reductase (SPR), by the drug sodium valproate. SPR encodes a key enzyme for neurotransmitter synthesis. Qdpr, encoding a protein in the same pathway, was also up-regulated by valproate, but to a lesser extent. SPR and members of the biopterin biosynthesis pathway have previously been implicated in the biology of depression. Another gene, the serotonin receptor 2A (Htr2a) was significantly down-regulated by the SSRIs paroxetine and citalopram. Having identified that valproate induced the most significant gene expression changes,I further conducted time-course and dose-response experiments to investigate the dynamics and pharmacology of valproate- induced gene expression changes. Spr and Hdac6, a member of the histone deacetylase gene family, were found to behave differently in these experiments. Subsequently, western blotting confirmed increased SPR protein expression in treated cells, and detected at least three isoforms recognised by a commercially sourced SPR antibody. Attempts to identify signalling pathways regulated by valproate failed to detect significant… Advisors/Committee Members: Kennedy, Martin (advisor).

Subjects/Keywords: gene regulation; mood disorders; antidepressants; sodium valproate

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Deng, X. (2011). Gene Regulation by Drugs Used to Treat Mood Disorders . (Doctoral Dissertation). University of Otago. Retrieved from http://hdl.handle.net/10523/1806

Chicago Manual of Style (16^th Edition):

Deng, Xiaoyan. “Gene Regulation by Drugs Used to Treat Mood Disorders .” 2011. Doctoral Dissertation, University of Otago. Accessed October 19, 2019. http://hdl.handle.net/10523/1806.

MLA Handbook (7^th Edition):

Deng, Xiaoyan. “Gene Regulation by Drugs Used to Treat Mood Disorders .” 2011. Web. 19 Oct 2019.

Vancouver:

Deng X. Gene Regulation by Drugs Used to Treat Mood Disorders . [Internet] [Doctoral dissertation]. University of Otago; 2011. [cited 2019 Oct 19]. Available from: http://hdl.handle.net/10523/1806.

Council of Science Editors:

Deng X. Gene Regulation by Drugs Used to Treat Mood Disorders . [Doctoral Dissertation]. University of Otago; 2011. Available from: http://hdl.handle.net/10523/1806

McGill University

16. Turk, Douglas J. The electrochemical detection of amitriptyline at a chemically modified reticulated vitreous carbon electrode surface.

Degree: MS, Department of Chemistry., 1985, McGill University

URL: http://digitool.library.mcgill.ca/thesisfile63368.pdf

Subjects/Keywords: Electrochemistry.; Antidepressants.; Amitriptyline.

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APA (6^th Edition):

Turk, D. J. (1985). The electrochemical detection of amitriptyline at a chemically modified reticulated vitreous carbon electrode surface. (Masters Thesis). McGill University. Retrieved from http://digitool.library.mcgill.ca/thesisfile63368.pdf

Chicago Manual of Style (16^th Edition):

Turk, Douglas J. “The electrochemical detection of amitriptyline at a chemically modified reticulated vitreous carbon electrode surface.” 1985. Masters Thesis, McGill University. Accessed October 19, 2019. http://digitool.library.mcgill.ca/thesisfile63368.pdf.

MLA Handbook (7^th Edition):

Turk, Douglas J. “The electrochemical detection of amitriptyline at a chemically modified reticulated vitreous carbon electrode surface.” 1985. Web. 19 Oct 2019.

Vancouver:

Turk DJ. The electrochemical detection of amitriptyline at a chemically modified reticulated vitreous carbon electrode surface. [Internet] [Masters thesis]. McGill University; 1985. [cited 2019 Oct 19]. Available from: http://digitool.library.mcgill.ca/thesisfile63368.pdf.

Council of Science Editors:

Turk DJ. The electrochemical detection of amitriptyline at a chemically modified reticulated vitreous carbon electrode surface. [Masters Thesis]. McGill University; 1985. Available from: http://digitool.library.mcgill.ca/thesisfile63368.pdf

Erasmus University Rotterdam

17. Molenaar, Nina. Antidepressants in the Perinatal Period : challenging choices in current practice.

Degree: 2018, Erasmus University Rotterdam

URL: http://hdl.handle.net/1765/112211

► markdownabstractSince much has already been written about the relation between antidepressants during pregnancy and increased risks in the offspring, the aim of this thesis is… (more)

Subjects/Keywords: Pregnancy; antidepressants; depression

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Molenaar, N. (2018). Antidepressants in the Perinatal Period : challenging choices in current practice. (Doctoral Dissertation). Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/112211

Chicago Manual of Style (16^th Edition):

Molenaar, Nina. “Antidepressants in the Perinatal Period : challenging choices in current practice.” 2018. Doctoral Dissertation, Erasmus University Rotterdam. Accessed October 19, 2019. http://hdl.handle.net/1765/112211.

MLA Handbook (7^th Edition):

Molenaar, Nina. “Antidepressants in the Perinatal Period : challenging choices in current practice.” 2018. Web. 19 Oct 2019.

Vancouver:

Molenaar N. Antidepressants in the Perinatal Period : challenging choices in current practice. [Internet] [Doctoral dissertation]. Erasmus University Rotterdam; 2018. [cited 2019 Oct 19]. Available from: http://hdl.handle.net/1765/112211.

Council of Science Editors:

Molenaar N. Antidepressants in the Perinatal Period : challenging choices in current practice. [Doctoral Dissertation]. Erasmus University Rotterdam; 2018. Available from: http://hdl.handle.net/1765/112211

University of Ottawa

18. Vahid-Ansari, Faranak. Altered Serotonin Regulation in Genetic and Post-Stroke Models of Anxiety and Depression .

Degree: 2017, University of Ottawa

URL: http://hdl.handle.net/10393/36839

► Major depression is a complex disease involving genetic and environmental factors. Previous studies suggest that functional genetic polymorphisms that alter the serotonin (5-HT) system in… (more)

▼ Major depression is a complex disease involving genetic and environmental factors. Previous studies suggest that functional genetic polymorphisms that alter the serotonin (5-HT) system in combination with psychosocial stress can synergistically increase the strength of these associations. In addition, depression is associated with several neurological disorders involving neuronal injury, including stroke (i.e. post-stroke depression, PSD). Both forms of depression are treated with 5-HT-selective antidepressants like fluoxetine, but remission rates do not exceed 50%. Evidence showed that alterations affecting the 5-HT system, directly or indirectly, lead to anxiety or depression phenotypes and may elucidate determinants of response to antidepressants. To better understand common and unique alterations in both genetic- and injury-related depression, I have generated and investigated two novel mouse models that exemplify a serotonin-related genetic risk (Flx-Freud-1 mice) and an injury model (ischemic lesion), to identify similarities and differences in their behavioral phenotypes, and in response to fluoxetine treatment. In the Flx-Freud-1 mouse model, 5-HT neuron-specific adult knockout of Freud-1, a key repressor of the 5-HT1A receptor gene, led to overexpression of 5-HT1A autoreceptors thought to negatively regulate the 5-HT system. These mice showed increased 5-HT1A autoreceptor responses, reduced 5-HT levels and a robust anxiety and depression phenotype that was resistant to chronic fluoxetine treatment. These behaviors were dependent on increased 5-HT1A autoreceptors since they were not seen in mice lacking 5-HT1A autoreceptors in adult Freud-1 knockout background. Instead an opposite anti-depressed phenotype emerged, suggesting that Freud-1 might have additional functions in 5-HT cells. In the PSD model, the vasoconstrictor endothelin-1 was injected to induce transient ischemia in the left medial prefrontal cortex, iv part of the circuitry thought to be damaged in PSD in humans. This stroke resulted in a persistent anxiety, depression and cognitive impairment. Chronic fluoxetine treatment alone or combined with voluntary exercise was effective to reverse the behavioral and cognitive phenotypes in this PSD mouse model.The results of genetic and SSRI treated stroke models show that changes in 5-HT system contribute to widespread dysregulation of the neuronal circuitry implicated in depression, anxiety. Genetic alteration of the 5-HT system conferred fluoxetine-resistance, while cortical stroke which indirectly altered the 5-HT system remained responsive to fluoxetine. Following unilateral stroke, there was increased activity of the contralateral hemisphere, including the prefrontal cortex and limbic areas involved in anxiety and depression, and activation of the 5-HT system. Effective treatment with chronic fluoxetine alone or combined with exercise significantly reduced and balanced the contralesional neuronal activation in affected regions that correlated with improvements in phenotypes. In conclusion, this…

Subjects/Keywords: Serotonin; Antidepressants; Depression; Anxiety; Genetics; Stroke

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APA (6^th Edition):

Vahid-Ansari, F. (2017). Altered Serotonin Regulation in Genetic and Post-Stroke Models of Anxiety and Depression . (Thesis). University of Ottawa. Retrieved from http://hdl.handle.net/10393/36839

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Vahid-Ansari, Faranak. “Altered Serotonin Regulation in Genetic and Post-Stroke Models of Anxiety and Depression .” 2017. Thesis, University of Ottawa. Accessed October 19, 2019. http://hdl.handle.net/10393/36839.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Vahid-Ansari, Faranak. “Altered Serotonin Regulation in Genetic and Post-Stroke Models of Anxiety and Depression .” 2017. Web. 19 Oct 2019.

Vancouver:

Vahid-Ansari F. Altered Serotonin Regulation in Genetic and Post-Stroke Models of Anxiety and Depression . [Internet] [Thesis]. University of Ottawa; 2017. [cited 2019 Oct 19]. Available from: http://hdl.handle.net/10393/36839.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Vahid-Ansari F. Altered Serotonin Regulation in Genetic and Post-Stroke Models of Anxiety and Depression . [Thesis]. University of Ottawa; 2017. Available from: http://hdl.handle.net/10393/36839

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Vrije Universiteit Amsterdam

19. Kieviet, N. Neonatal symptoms after exposure to antidepressants in utero .

Degree: 2016, Vrije Universiteit Amsterdam

URL: http://hdl.handle.net/1871/53868

Subjects/Keywords: antidepressants pregnancy withdrawal

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kieviet, N. (2016). Neonatal symptoms after exposure to antidepressants in utero . (Doctoral Dissertation). Vrije Universiteit Amsterdam. Retrieved from http://hdl.handle.net/1871/53868

Chicago Manual of Style (16^th Edition):

Kieviet, N. “Neonatal symptoms after exposure to antidepressants in utero .” 2016. Doctoral Dissertation, Vrije Universiteit Amsterdam. Accessed October 19, 2019. http://hdl.handle.net/1871/53868.

MLA Handbook (7^th Edition):

Kieviet, N. “Neonatal symptoms after exposure to antidepressants in utero .” 2016. Web. 19 Oct 2019.

Vancouver:

Kieviet N. Neonatal symptoms after exposure to antidepressants in utero . [Internet] [Doctoral dissertation]. Vrije Universiteit Amsterdam; 2016. [cited 2019 Oct 19]. Available from: http://hdl.handle.net/1871/53868.

Council of Science Editors:

Kieviet N. Neonatal symptoms after exposure to antidepressants in utero . [Doctoral Dissertation]. Vrije Universiteit Amsterdam; 2016. Available from: http://hdl.handle.net/1871/53868

Columbia University

20. Kruegel, Andrew Carry. Chemical and Biological Explorations of Novel Opioid Receptor Modulators.

Degree: 2015, Columbia University

URL: https://doi.org/10.7916/D8V1242F

► This report describes the synthesis, chemical derivation, and pharmacological and behavioral characterization of several unique classes of opioid receptor modulators. In chapter one, a general… (more)

▼ This report describes the synthesis, chemical derivation, and pharmacological and behavioral characterization of several unique classes of opioid receptor modulators. In chapter one, a general overview of opioid receptor history, signaling biology, and therapeutic applications is provided. Also reviewed are several topics of high current interest, including, biased signaling, opioid receptor splice variants/heteromers, and applications of opioid modulators in the treatment of mood disorders. This introduction aims to frame the work that follows, and emphasize to the reader the untapped potential of the opioid receptor system, particularly in the realm of therapeutics development. Chapter two discusses the development of several new C-H activation reactions to provide rapid access to the core molecular scaffold of alkaloids from Tabernanthe iboga. The methods described permit the expedient construction of structurally diverse ibogamine analogs via a modular approach. In chapter three, this work is extended by applying the new reaction methodologies to explore a novel class of oxaibogamine analogs, which act as opioid receptor agonists and antagonists. The thorough exploration of structure-activity relationships within this skeleton is described, along with the pharmacological characterization of several select analogs as biased agonists at both the kappa- and mu-opioid receptors. This section concludes with a discussion of potential therapeutic applications for the synthesized compounds as new analgesics and antidepressants, and future goals and plans for this structural class. In chapter four, the isolation and pharmacological study of several alkaloids of Mitragyna speciosa is presented. Mitragynine, the primary natural alkaloid in this plant, is isolated, along with several naturally occurring analogs, and the modulatory activity of these compounds at the opioid receptors is fully characterized. Further, preliminary results are presented suggesting activity of these alkaloids at several other classes of central nervous system targets, including serotonin and adrenergic receptors. Also discussed are the preparations of semi-synthetic and fully synthetic mitragynine derivatives, including a total synthesis of mitragynine itself. These novel analogs are applied to explore key structure-activity relationships in this unusual opioid-active scaffold. Again, potential applications of Mitragyna alkaloid analogs in the treatment of pain and depression are discussed. In the final chapter, I describe our discovery that tianeptine, a clinically used atypical antidepressant of previously unknown mechanism of action, acts as an agonist of both the mu- and delta-opioid receptors. Activation of the mu-opioid receptor is thus proposed as the initial molecular-level event responsible for eliciting the beneficial therapeutic effects of this agent. This hypothesis is integrated with the large body of literature describing this compound, and mechanistic theories connecting the opioid activity of tianeptine to…

Subjects/Keywords: Opioids – Receptors; Antidepressants; Therapeutics; Chemistry; Pharmacology

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APA (6^th Edition):

Kruegel, A. C. (2015). Chemical and Biological Explorations of Novel Opioid Receptor Modulators. (Doctoral Dissertation). Columbia University. Retrieved from https://doi.org/10.7916/D8V1242F

Chicago Manual of Style (16^th Edition):

Kruegel, Andrew Carry. “Chemical and Biological Explorations of Novel Opioid Receptor Modulators.” 2015. Doctoral Dissertation, Columbia University. Accessed October 19, 2019. https://doi.org/10.7916/D8V1242F.

MLA Handbook (7^th Edition):

Kruegel, Andrew Carry. “Chemical and Biological Explorations of Novel Opioid Receptor Modulators.” 2015. Web. 19 Oct 2019.

Vancouver:

Kruegel AC. Chemical and Biological Explorations of Novel Opioid Receptor Modulators. [Internet] [Doctoral dissertation]. Columbia University; 2015. [cited 2019 Oct 19]. Available from: https://doi.org/10.7916/D8V1242F.

Council of Science Editors:

Kruegel AC. Chemical and Biological Explorations of Novel Opioid Receptor Modulators. [Doctoral Dissertation]. Columbia University; 2015. Available from: https://doi.org/10.7916/D8V1242F

Queens University

21. Kennedy, Gregory L. The Effect of Antidepressants on Cardiovascular Morbidity and Mortality: A Population-based Cohort Study .

Degree: Community Health and Epidemiology, 2007, Queens University

URL: http://hdl.handle.net/1974/680

► Background: Antidepressants such as selective serotonin reuptake inhibitors (SSRIs) and venlafaxine have the potential to exert beneficial effects on the heart via serotonin mediated antiplatelet… (more)

▼ Background: Antidepressants such as selective serotonin reuptake inhibitors (SSRIs) and venlafaxine have the potential to exert beneficial effects on the heart via serotonin mediated antiplatelet activity. However, previous evidence regarding the cardiovascular effects of these agents has been conflicting. There is a need for further investigation into the risks and benefits of these drugs. Objective: To assess the risk of acute MI and cardiac death associated the use of various classes of antidepressants, and determine whether this risk is modified by the presence of predisposing factors. Methods: We identified a population-based, retrospective cohort study of 71,253 elderly persons initiating treatment with an antidepressant between 1997 and 2004. The cohort was analyzed using nested case-control approach with each case of acute MI or cardiac death matched with up to 20 controls according to age (±1 year), duration of follow-up, and year of cohort entry. Rate ratios for acute MI and cardiac death associated with the current use of various antidepressants were estimated using conditional logistic regression and adjusted for potential confounders. Results: Compared with the current use of atypical antidepressants, current use of venlafaxine was associated with a significant reduction in the risk of MI and cardiac death (rate ratio [RR] 0.80 [95% CI 0.66 to 0.97]) that was more pronounced in persons with established cardiovascular disease (CVD) (RR 0.65 [CI 0.50 to 0.86]). We found no clear evidence of a benefit or harm associated with the use of SSRIs (RR 0.92 [CI 0.79 to 1.06]), although there was the suggestion of a clinically important benefit from treatment with SSRIs for individuals who had history of MI (RR 0.68 [CI 0.44 to 1.07]). No benefit or harm was observed with other classes of antidepressants. Conclusions: These results demonstrate a reduced risk for acute MI and cardiac death associated with current use of venlafaxine among elderly persons. This beneficial effect appears to be more pronounced in those with established cardiovascular disease. No clear evidence of benefit on CV outcomes was associated with the current use of SSRIs, although results suggest a potential benefit for use in persons with a previous MI.

Subjects/Keywords: antidepressants; cardiovascular risk

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APA (6^th Edition):

Kennedy, G. L. (2007). The Effect of Antidepressants on Cardiovascular Morbidity and Mortality: A Population-based Cohort Study . (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/680

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kennedy, Gregory L. “The Effect of Antidepressants on Cardiovascular Morbidity and Mortality: A Population-based Cohort Study .” 2007. Thesis, Queens University. Accessed October 19, 2019. http://hdl.handle.net/1974/680.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kennedy, Gregory L. “The Effect of Antidepressants on Cardiovascular Morbidity and Mortality: A Population-based Cohort Study .” 2007. Web. 19 Oct 2019.

Vancouver:

Kennedy GL. The Effect of Antidepressants on Cardiovascular Morbidity and Mortality: A Population-based Cohort Study . [Internet] [Thesis]. Queens University; 2007. [cited 2019 Oct 19]. Available from: http://hdl.handle.net/1974/680.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kennedy GL. The Effect of Antidepressants on Cardiovascular Morbidity and Mortality: A Population-based Cohort Study . [Thesis]. Queens University; 2007. Available from: http://hdl.handle.net/1974/680

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Alberta

22. Todd, Kathryn Grace. Gabaergic mechanisms of the antidepressant/antipanic drug phenelzine.

Degree: PhD, Faculty of Pharmacy and Pharmaceutical Sciences Faculty of Medicine, 1994, University of Alberta

URL: https://era.library.ualberta.ca/files/6969z336h

Subjects/Keywords: GABA – Effect of antidepressants on.; Antidepressants.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Todd, K. G. (1994). Gabaergic mechanisms of the antidepressant/antipanic drug phenelzine. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/6969z336h

Chicago Manual of Style (16^th Edition):

Todd, Kathryn Grace. “Gabaergic mechanisms of the antidepressant/antipanic drug phenelzine.” 1994. Doctoral Dissertation, University of Alberta. Accessed October 19, 2019. https://era.library.ualberta.ca/files/6969z336h.

MLA Handbook (7^th Edition):

Todd, Kathryn Grace. “Gabaergic mechanisms of the antidepressant/antipanic drug phenelzine.” 1994. Web. 19 Oct 2019.

Vancouver:

Todd KG. Gabaergic mechanisms of the antidepressant/antipanic drug phenelzine. [Internet] [Doctoral dissertation]. University of Alberta; 1994. [cited 2019 Oct 19]. Available from: https://era.library.ualberta.ca/files/6969z336h.

Council of Science Editors:

Todd KG. Gabaergic mechanisms of the antidepressant/antipanic drug phenelzine. [Doctoral Dissertation]. University of Alberta; 1994. Available from: https://era.library.ualberta.ca/files/6969z336h

23. Silva, William Kleber da. Desenvolvimento e validação de análise de duloxetina em plasma humano, simultânea a outros antidepressivos, por cromatografia líquida de alta eficiência.

Degree: Mestrado, Toxicologia, 2014, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/60/60134/tde-27112014-144038/ ;

►

Atualmente, a quantidade de pacientes que são diagnosticados com alguma forma de depressão, entre elas, o transtorno depressivo maior, aumenta consideravelmente, quer seja em razão… (more)

▼

Atualmente, a quantidade de pacientes que são diagnosticados com alguma forma de depressão, entre elas, o transtorno depressivo maior, aumenta consideravelmente, quer seja em razão de diagnósticos mais precisos ou pela própria epidemiologia da doença. Acresça-se o fato de que muitos pacientes, apesar da quantidade de tipos de antidepressivos atualmente disponíveis para a terapêutica, são refratários ao tratamento prescrito, em razão dos efeitos adversos apresentados, ou de seus efeitos tóxicos, ou ainda por simplesmente não se observar melhora com a prescrição seguida. Portanto, novos tratamentos farmacológicos são disponibilizados, e entre eles, a duloxetina, um duplo inibidor de recaptação de serotonina e norepinefrina. Para auxiliar na máxima eficácia em sua utilização, esse trabalho apresenta metodologia em HPLC para determinação simultânea de sete antidepressivos, tricíclicos e não tricíclicos, moclobemida, venlafaxina, citalopram, agomelatina, duloxetina, amitriptilina e sertralina, em plasma humano, para posteriormente ser aplicada na monitorização de pacientes depressivos. O simples e preciso método de preparo da amostra consiste na extração líquido-líquido, com recuperação entre 73% a 86% (exceto para moclobemida, de 55%), e para a duloxetina, de aproximadamente 73%. A separação foi obtida usando uma coluna em fase reversa Lichrospher® 60 RP-select B em LichroCART 250mm x 4mm, 5?m de diâmetro interno, Merck, sob condições isocráticas, com detecção em UV em 230nm, com fase móvel composta por 35% de uma mistura de acetonitrila:metanol 55/5 (v/v) e 65% de tampão acetato 0,25M, pH 4,4. As curvas padrões foram lineares em uma faixa de trabalho de 2,5-1000ng/mL para moclobemida, 5-2000ng/mL para venlafaxina, citalopram, agomelatina, duloxetina e amitriptilina, e 10-2000ng/mL para sertralina. As precisões intra e interensaios foram efetuadas em três concentrações (50, 200 e 500ng/mL). Os coeficientes de variação para a precisão intraensaio foram menores que 8,6% para todos os compostos e os coeficientes de variação para a precisão interensaio foram menores que 8,5%. Os limites de quantificação foram de 2,5ng/mL para a moclobemida, 5ng/mL para venlafaxina, citalopram, duloxetina, agomelatina, amitriptilina e 10ng/mL para sertralina. Não se observou qualquer interferência das drogas normalmente associadas aos antidepressivos.

Currently, the number of patients who are diagnosed with some form of depression, among them, major depressive disorder, increases considerably, either because of more accurate diagnosis or by the epidemiology of the disease. One should add the fact that many patients, despite the amount of types of antidepressants currently available for therapy are refractory to the treatment prescribed, because of the adverse effects appear, or their toxic effects, or by simply not observed improvement then the prescription. Therefore, new pharmacological treatments are available, and among them, duloxetine, a dual reuptake inhibitor of serotonin and norepinephrine. To assist in maximum effectiveness in…

Advisors/Committee Members: Queiroz, Regina Helena Costa.

Subjects/Keywords: antidepressivos não tricíclicos; antidepressivos tricíclicos; detecção por UV; HPLC; HPLC; monitorização terapêutica; not tricyclic antidepressants; therapeutic monitoring; tricyclic antidepressants; UV detection

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Silva, W. K. d. (2014). Desenvolvimento e validação de análise de duloxetina em plasma humano, simultânea a outros antidepressivos, por cromatografia líquida de alta eficiência. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/60/60134/tde-27112014-144038/ ;

Chicago Manual of Style (16^th Edition):

Silva, William Kleber da. “Desenvolvimento e validação de análise de duloxetina em plasma humano, simultânea a outros antidepressivos, por cromatografia líquida de alta eficiência.” 2014. Masters Thesis, University of São Paulo. Accessed October 19, 2019. http://www.teses.usp.br/teses/disponiveis/60/60134/tde-27112014-144038/ ;.

MLA Handbook (7^th Edition):

Silva, William Kleber da. “Desenvolvimento e validação de análise de duloxetina em plasma humano, simultânea a outros antidepressivos, por cromatografia líquida de alta eficiência.” 2014. Web. 19 Oct 2019.

Vancouver:

Silva WKd. Desenvolvimento e validação de análise de duloxetina em plasma humano, simultânea a outros antidepressivos, por cromatografia líquida de alta eficiência. [Internet] [Masters thesis]. University of São Paulo; 2014. [cited 2019 Oct 19]. Available from: http://www.teses.usp.br/teses/disponiveis/60/60134/tde-27112014-144038/ ;.

Council of Science Editors:

Silva WKd. Desenvolvimento e validação de análise de duloxetina em plasma humano, simultânea a outros antidepressivos, por cromatografia líquida de alta eficiência. [Masters Thesis]. University of São Paulo; 2014. Available from: http://www.teses.usp.br/teses/disponiveis/60/60134/tde-27112014-144038/ ;

University of Florida

24. Mills, Jon C. Comparative Effectiveness of Dual-Action versus Single-Action Antidepressants for Treatment of People Diagnosed with Co-Occurring HIV/AIDS and Major Depression A Growing Syndemic.

Degree: PhD, Health Services Research - Health Services Research, Management, and Policy, 2016, University of Florida

URL: http://ufdc.ufl.edu/UFE0050147

► Major depressive disorder is the most common psychiatric comorbidity among people living with HIV/AIDS. It is linked to poor antiretroviral adherence, increased viral loads, low… (more)

Subjects/Keywords: Antidepressants; Anxiety; Art periods; Diagnostic indices; HIV; Major depressive disorder; Medications; Modeling; Statistical significance; Viral load; antidepressants – comparative – depression – effectiveness – hiv

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mills, J. C. (2016). Comparative Effectiveness of Dual-Action versus Single-Action Antidepressants for Treatment of People Diagnosed with Co-Occurring HIV/AIDS and Major Depression A Growing Syndemic. (Doctoral Dissertation). University of Florida. Retrieved from http://ufdc.ufl.edu/UFE0050147

Chicago Manual of Style (16^th Edition):

Mills, Jon C. “Comparative Effectiveness of Dual-Action versus Single-Action Antidepressants for Treatment of People Diagnosed with Co-Occurring HIV/AIDS and Major Depression A Growing Syndemic.” 2016. Doctoral Dissertation, University of Florida. Accessed October 19, 2019. http://ufdc.ufl.edu/UFE0050147.

MLA Handbook (7^th Edition):

Mills, Jon C. “Comparative Effectiveness of Dual-Action versus Single-Action Antidepressants for Treatment of People Diagnosed with Co-Occurring HIV/AIDS and Major Depression A Growing Syndemic.” 2016. Web. 19 Oct 2019.

Vancouver:

Mills JC. Comparative Effectiveness of Dual-Action versus Single-Action Antidepressants for Treatment of People Diagnosed with Co-Occurring HIV/AIDS and Major Depression A Growing Syndemic. [Internet] [Doctoral dissertation]. University of Florida; 2016. [cited 2019 Oct 19]. Available from: http://ufdc.ufl.edu/UFE0050147.

Council of Science Editors:

Mills JC. Comparative Effectiveness of Dual-Action versus Single-Action Antidepressants for Treatment of People Diagnosed with Co-Occurring HIV/AIDS and Major Depression A Growing Syndemic. [Doctoral Dissertation]. University of Florida; 2016. Available from: http://ufdc.ufl.edu/UFE0050147

University of Alberta

25. Hussain, Mohammed Saleh. Analysis and metabolism of trimipramine, iprindole and imipramine in mammals.

Degree: PhD, Faculty of Pharmacy and Pharmaceutical Sciences, 1992, University of Alberta

URL: https://era.library.ualberta.ca/files/cz30pv520

Subjects/Keywords: Antidepressants – Metabolism.; Psychopharmacology – Animal models.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hussain, M. S. (1992). Analysis and metabolism of trimipramine, iprindole and imipramine in mammals. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/cz30pv520

Chicago Manual of Style (16^th Edition):

Hussain, Mohammed Saleh. “Analysis and metabolism of trimipramine, iprindole and imipramine in mammals.” 1992. Doctoral Dissertation, University of Alberta. Accessed October 19, 2019. https://era.library.ualberta.ca/files/cz30pv520.

MLA Handbook (7^th Edition):

Hussain, Mohammed Saleh. “Analysis and metabolism of trimipramine, iprindole and imipramine in mammals.” 1992. Web. 19 Oct 2019.

Vancouver:

Hussain MS. Analysis and metabolism of trimipramine, iprindole and imipramine in mammals. [Internet] [Doctoral dissertation]. University of Alberta; 1992. [cited 2019 Oct 19]. Available from: https://era.library.ualberta.ca/files/cz30pv520.

Council of Science Editors:

Hussain MS. Analysis and metabolism of trimipramine, iprindole and imipramine in mammals. [Doctoral Dissertation]. University of Alberta; 1992. Available from: https://era.library.ualberta.ca/files/cz30pv520

University of Alberta

26. Lee, Kuen-Shan Steven. Separation and quantitation of the enantiomers of trimipramine.

Degree: MS, Faculty of Pharmacy and Pharmaceutical Sciences, 1996, University of Alberta

URL: https://era.library.ualberta.ca/files/4q77ft374

Subjects/Keywords: Rats – Physiology.; Enantiomers – Separation.; Antidepressants.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lee, K. S. (1996). Separation and quantitation of the enantiomers of trimipramine. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/4q77ft374

Chicago Manual of Style (16^th Edition):

Lee, Kuen-Shan Steven. “Separation and quantitation of the enantiomers of trimipramine.” 1996. Masters Thesis, University of Alberta. Accessed October 19, 2019. https://era.library.ualberta.ca/files/4q77ft374.

MLA Handbook (7^th Edition):

Lee, Kuen-Shan Steven. “Separation and quantitation of the enantiomers of trimipramine.” 1996. Web. 19 Oct 2019.

Vancouver:

Lee KS. Separation and quantitation of the enantiomers of trimipramine. [Internet] [Masters thesis]. University of Alberta; 1996. [cited 2019 Oct 19]. Available from: https://era.library.ualberta.ca/files/4q77ft374.

Council of Science Editors:

Lee KS. Separation and quantitation of the enantiomers of trimipramine. [Masters Thesis]. University of Alberta; 1996. Available from: https://era.library.ualberta.ca/files/4q77ft374

Texas A&M University

27. Shannonhouse, John Lorenz. Syrian Hamsters as a Clinically Relevant Model for Mood Disorders.

Degree: 2017, Texas A&M University

URL: http://hdl.handle.net/1969.1/161286

► Anxiety and depressive disorders are the two most common types of mood disorders in the United States. These disorders are more likely to affect women… (more)

▼ Anxiety and depressive disorders are the two most common types of mood disorders in the United States. These disorders are more likely to affect women than men. Animal models do not cover key aspects of mood disorders well, including sex biases, links between metabolism, HPA activity, social status and anxiety and depression as well as paradoxical effects of antidepressants on some adolescents. It is reported here that two novel tests, the anxiety feeding/exploration conflict (AFEC) test and the reward/investigational preference (RIP) test, are suitable for measuring anxiety-like and depression-like behavior in Syrian hamsters (Mesocricetus auratus). Furthermore, biometrics including body weight, food intake, indirect calorimetry, plasma assays and tissue weights measured metabolism. Gene expression and electrophysiology were used to measure brain function. Pharmacological interventions manipulated behavior and metabolism. Animals were manipulated through social housing (SH, 2 or more animals per cage) and social separation (SS, one animal per cage) and pharmacology to model mood disorders in humans. Relative to SH, SS hamsters show a combination of increased metabolic rate, hypophagia, decreased adiposity, decreased lean mass, low HPA activity and increased anxiety-like and depression-like behaviors with a profound female sex bias. Relative to adult female Syrian hamsters, adolescent female Syrian hamsters show aberrant responses to the antidepressant fluoxetine including increased anxiety-like behavior, increased depression-like behavior and anxiety-like and depression-like behavior that do not improve over the course of the experiment. In addition, there are divergent responses of gamma-amino butyric acid (GABA) miniature inhibitory chloride currents and divergent GABA-related gene expression. Thus, the Syrian hamster model shows advantages over related models in rats and mice for some aspects of modeling anxiety and depression. Advisors/Committee Members: Smotherman, Mike (advisor), Morgan, Caurnel (committee member), Eitan, Shoshana (committee member), Frye, Gerald (committee member).

Subjects/Keywords: Depression; Anxiety; Hamsters; Antidepressants; Adolescents; Sex Differences; Age Differences; Behavior Tests

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APA (6^th Edition):

Shannonhouse, J. L. (2017). Syrian Hamsters as a Clinically Relevant Model for Mood Disorders. (Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/161286

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Shannonhouse, John Lorenz. “Syrian Hamsters as a Clinically Relevant Model for Mood Disorders.” 2017. Thesis, Texas A&M University. Accessed October 19, 2019. http://hdl.handle.net/1969.1/161286.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Shannonhouse, John Lorenz. “Syrian Hamsters as a Clinically Relevant Model for Mood Disorders.” 2017. Web. 19 Oct 2019.

Vancouver:

Shannonhouse JL. Syrian Hamsters as a Clinically Relevant Model for Mood Disorders. [Internet] [Thesis]. Texas A&M University; 2017. [cited 2019 Oct 19]. Available from: http://hdl.handle.net/1969.1/161286.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Shannonhouse JL. Syrian Hamsters as a Clinically Relevant Model for Mood Disorders. [Thesis]. Texas A&M University; 2017. Available from: http://hdl.handle.net/1969.1/161286

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

28. Juniku, Rajan B. Part I: Synthesis and evaluation of synosutine as an inhibitor of serotonin, norepinephrine, and dopamine transporters Part II: Asymmetric approach to the tetracyclic core of neomangicol A.

Degree: PhD, Chemistry, 2012, Oregon State University

URL: http://hdl.handle.net/1957/30439

► Part I: Racemic and asymmetric syntheses of a new substance with prospective antidepressant properties were achieved. In vitro assays with synthetic racemates (±)-25 and (±)-26… (more)

▼ Part I: Racemic and asymmetric syntheses of a new substance with prospective antidepressant properties were achieved. In vitro assays with synthetic racemates (±)-25 and (±)-26 suggested that the former is a relatively selective inhibitor of serotonin transporter whereas the latter is a more balanced inhibitor of both serotonin and norepinephrine transporter. An initial approach to enantiomers of 25 and 26 via resolution of carboxylic acids 21 and 22 was unsuccessful but a de novo strategy which introduced asymmetry by means of Charette enantioselective cyclopropanation led to (+)-25, (-)-25, (+)-26 and (-)-26. In vitro assays with (+)-26, now known as synosutine synthesis/OSU), indicate that this substance is a highly effective dual inhibitor of serotonin and norepinephrine transporter. With IC₅₀ and K[subscript i] values in the 1-2 nM range, (+)-26 compares favorably with Eli Lilly's duloxetine (Cymbalta®) as a dual reuptake inhibitor of serotonin and norepinephrine and is thus a potential candidate for development as a drug for treatment of clinical depression. Synosutine was also assayed in vivo for its binding to human monoamine transporters. These studies indicate that synosutine, with a K[subscript i] of 1.2 nM for norepinephrine and 2.1 nM for serotonin, is a more balanced inhibitor than duloxetin. Part II: Synthetic studies towards the tetracyclic core structure of neomangicol A (129) led to advanced intermediate 245 which bears rings A and D of the neomangicol nucleus. This bicylic enone carries the correct stereochemical imprint for tetracycle 129 at C5, C6 and C14 and it contains all of carbon atoms needed to assemble the remaining two rings. Synthesis of bicyclic lactone 170, the precursor for ring A, was accomplished from the monoterpene (S)-(+)-carvone via radical cyclization and a series of Baeyer-Villiger oxidations as the key steps. Alkylation of 170 with alkyl iodide 217, obtained from the monoterpene (S)-(-)-citronellol furnished advanced intermediate 218 which was converted into diene 244. Ring closing metathesis of 244 with Grubbs-Hoveyda second generation catalyst afforded 245. Exploratory functionalization of 245 was carried out for the purpose of assembling rings B and C of the complete neomangicol skeleton. Advisors/Committee Members: White, James (advisor), Carter, Rich (committee member).

Subjects/Keywords: Synosutine; Antidepressants – Synthesis

…can be categorized into four groups: (1) tricyclic antidepressants (TCA)… …oxidase inhibitors (MAOI), and (4) atypical antidepressants (AA).5…

10 more images…

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APA (6^th Edition):

Juniku, R. B. (2012). Part I: Synthesis and evaluation of synosutine as an inhibitor of serotonin, norepinephrine, and dopamine transporters Part II: Asymmetric approach to the tetracyclic core of neomangicol A. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/30439

Chicago Manual of Style (16^th Edition):

Juniku, Rajan B. “Part I: Synthesis and evaluation of synosutine as an inhibitor of serotonin, norepinephrine, and dopamine transporters Part II: Asymmetric approach to the tetracyclic core of neomangicol A.” 2012. Doctoral Dissertation, Oregon State University. Accessed October 19, 2019. http://hdl.handle.net/1957/30439.

MLA Handbook (7^th Edition):

Juniku, Rajan B. “Part I: Synthesis and evaluation of synosutine as an inhibitor of serotonin, norepinephrine, and dopamine transporters Part II: Asymmetric approach to the tetracyclic core of neomangicol A.” 2012. Web. 19 Oct 2019.

Vancouver:

Juniku RB. Part I: Synthesis and evaluation of synosutine as an inhibitor of serotonin, norepinephrine, and dopamine transporters Part II: Asymmetric approach to the tetracyclic core of neomangicol A. [Internet] [Doctoral dissertation]. Oregon State University; 2012. [cited 2019 Oct 19]. Available from: http://hdl.handle.net/1957/30439.

Council of Science Editors:

Juniku RB. Part I: Synthesis and evaluation of synosutine as an inhibitor of serotonin, norepinephrine, and dopamine transporters Part II: Asymmetric approach to the tetracyclic core of neomangicol A. [Doctoral Dissertation]. Oregon State University; 2012. Available from: http://hdl.handle.net/1957/30439

29. Carlos Eduardo de Souza Menezes. AlteraÃÃes cogntivas e neuroquimicas pelo uso crÃnico de monoterapia e terapia combinada de antidepressivos em ratos.

Degree: Master, 2012, Universidade Federal do Ceará

URL: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=8097 ;

► IntroduÃÃo: DepressÃo Ã uma condiÃÃo psicopatolÃgica crÃnica e recorrente, com evidentes prejuÃzos sÃcio-ocupacionais e de qualidade de vida, tanto na fase aguda quanto no longo… (more)

▼ IntroduÃÃo: DepressÃo Ã uma condiÃÃo psicopatolÃgica crÃnica e recorrente, com evidentes prejuÃzos sÃcio-ocupacionais e de qualidade de vida, tanto na fase aguda quanto no longo prazo. A depressÃo Ã causada por um dÃficit funcional das monoaminas nas suas vias transmissoras (serotoninÃrgicas, noradrenÃrgica e dopaminÃrgicas) em certos locais do cÃrebro. Apesar de existirem diversas formas de tratamento clÃnico desse transtorno do humor como: psicoterapia, antidepressivos, ECT e TMS, a prescriÃÃo das drogas antidepressivas representa a principal forma de manejo das chamadas depressÃes endÃgenas. A modulaÃÃo funcional das vias de transmissÃo neuroquÃmica pode interferir no desempenho do processamento de funÃÃes cognitivas como a memÃria. Objetivo: Nosso estudo procurou investigar as possÃveis alteraÃÃes em diferentes tipos e fases da memÃria provocadas pelo uso crÃnico de diferentes manejos de antidepressivos; monoterapia e terapia combinada. MÃtodos: Utilizamos nessa pesquisa a administraÃÃo crÃnica de trÃs drogas antidepressivas e suas associaÃÃes (Paroxetina, Venlafaxina e Bupropiona) de largo uso na prÃtica clÃnica. Para avaliaÃÃo do desempenho mnemÃnico utilizamos modelos comportamentais para ratos com alto valor preditivo para memÃria (labirinto radial, esquiva passiva) e para atividade exploratÃria (campo aberto). Foram medidos os nÃveis de BDNF e a atividade enzimÃtica da AChE do hipocampo dos grupos de ratos usuÃrios de antidepressivos. Resultados: No Labirinto Radial â fase de aquisiÃÃo: os grupos Venlaf (11Â4,85), Venlaf+Parox (10,88Â5,30) e Venlaf + Buprop (11Â3,85) apresentaram nÃmero de tentativas de treinos significativamente maior comparado ao desempenho dos animais do grupo controle (5,11Â1,36), enquanto os grupos com Parox (4,14Â2,19), Buprop (7,1Â3,66) sozinha e Parox + Bup (4,75Â1,75) nÃo apresentaram alteraÃÃes do nÃmero de tentativas significantes. Labirinto Radial â MC: os grupos Venlaf (2,16Â1,47), Venlaf+Parox (2,85Â1,35) e Venla + Bup (2,62Â1,76) nÃo apresentaram alteraÃÃes significantes em comparaÃÃo ao grupo usuÃrio da soluÃÃo salina (2,25Â1,58), enquanto que os usuÃrios dos antidepressivos Parox (3,11Â1,69), Bup (4,9Â2,99) e Parox + Bup (4,12Â2,58) apresentaram um nÃmero significativamente (p<0,001) maior de erros em relaÃÃo ao grupo controle (2,25Â1,58). Labirinto Radial â ML: grupos usuÃrios de Venla (4,5Â1,64), Buprop (4Â2,3) e Venlaf+ Bup (2,87Â1,72) nÃo apresentaram alteraÃÃes significativamente diferente do grupo controle (3.11Â1,36), enquanto que o grupo usuÃrio de Parox (4,4Â1,50) apresentou um nÃmero significativamente maior de erros em relaÃÃo ao grupo controle (3.11Â1,36). Os grupos usuÃrios de Venlaf + Parox (2,66Â0,85) e Parox+Buprop (3,12Â2,16) apresentaram um nÃmero de erros significativamente menor quando comparados ao nÃmero de erros na Parox (4,4Â1,50). Esquiva Passiva â MC e ML:os grupos usuÃrios de Parox (218,4Â113,1), Bup (39,57Â23,19) e Parox+Buprop (300Â0,0) apresentaram um tempo de latÃncia significativamente (p<0,001) maior em relaÃÃo ao grupo controle (270Â37,30).… Advisors/Committee Members: Danielle MacÃdo Gaspar, David Freitas de Lucena, Jairo Diniz Filho.

Subjects/Keywords: FARMACOLOGIA; Antidepressivos; TerapÃutica; MemÃria; Aprendizagem; Ratos; antidepressants; therapy; memory; rats

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Menezes, C. E. d. S. (2012). AlteraÃÃes cogntivas e neuroquimicas pelo uso crÃnico de monoterapia e terapia combinada de antidepressivos em ratos. (Masters Thesis). Universidade Federal do Ceará. Retrieved from http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=8097 ;

Chicago Manual of Style (16^th Edition):

Menezes, Carlos Eduardo de Souza. “AlteraÃÃes cogntivas e neuroquimicas pelo uso crÃnico de monoterapia e terapia combinada de antidepressivos em ratos.” 2012. Masters Thesis, Universidade Federal do Ceará. Accessed October 19, 2019. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=8097 ;.

MLA Handbook (7^th Edition):

Menezes, Carlos Eduardo de Souza. “AlteraÃÃes cogntivas e neuroquimicas pelo uso crÃnico de monoterapia e terapia combinada de antidepressivos em ratos.” 2012. Web. 19 Oct 2019.

Vancouver:

Menezes CEdS. AlteraÃÃes cogntivas e neuroquimicas pelo uso crÃnico de monoterapia e terapia combinada de antidepressivos em ratos. [Internet] [Masters thesis]. Universidade Federal do Ceará 2012. [cited 2019 Oct 19]. Available from: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=8097 ;.

Council of Science Editors:

Menezes CEdS. AlteraÃÃes cogntivas e neuroquimicas pelo uso crÃnico de monoterapia e terapia combinada de antidepressivos em ratos. [Masters Thesis]. Universidade Federal do Ceará 2012. Available from: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=8097 ;

30. Guna, P. Effects of a few antidepressants on toxicity and sexual behavior of Drosophila Melanogaster;.

Degree: 2012, University of Mysore

URL: http://shodhganga.inflibnet.ac.in/handle/10603/35920

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Advisors/Committee Members: Hegde, S. N..

Subjects/Keywords: Antidepressants; Chromosomes; Drosophila Melanogaster

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Guna, P. (2012). Effects of a few antidepressants on toxicity and sexual behavior of Drosophila Melanogaster;. (Thesis). University of Mysore. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/35920

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Guna, P. “Effects of a few antidepressants on toxicity and sexual behavior of Drosophila Melanogaster;.” 2012. Thesis, University of Mysore. Accessed October 19, 2019. http://shodhganga.inflibnet.ac.in/handle/10603/35920.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Guna, P. “Effects of a few antidepressants on toxicity and sexual behavior of Drosophila Melanogaster;.” 2012. Web. 19 Oct 2019.

Vancouver:

Guna P. Effects of a few antidepressants on toxicity and sexual behavior of Drosophila Melanogaster;. [Internet] [Thesis]. University of Mysore; 2012. [cited 2019 Oct 19]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/35920.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Guna P. Effects of a few antidepressants on toxicity and sexual behavior of Drosophila Melanogaster;. [Thesis]. University of Mysore; 2012. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/35920

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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