subject:(anti inflammatory)

Deakin University

1. DOBSON, POLLY. Biocatalysis of Soybean 15-Lipoxygenase for the production of lipid mediators of Inflammation.

Degree: School of Life and Environmental Sciences, 2016, Deakin University

URL: http://hdl.handle.net/10536/DRO/DU:30089039

► This thesis describes the application of a plant enzyme, soybean 15-lipoxygenase-1, in the production of lipid-based mediators of inflammation from omega-3 fatty acids. Several methods… (more)

Subjects/Keywords: inflammatory diseases; Plant enzymes; anti-inflammatory compounds

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APA (6^th Edition):

DOBSON, P. (2016). Biocatalysis of Soybean 15-Lipoxygenase for the production of lipid mediators of Inflammation. (Thesis). Deakin University. Retrieved from http://hdl.handle.net/10536/DRO/DU:30089039

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

DOBSON, POLLY. “Biocatalysis of Soybean 15-Lipoxygenase for the production of lipid mediators of Inflammation.” 2016. Thesis, Deakin University. Accessed January 18, 2021. http://hdl.handle.net/10536/DRO/DU:30089039.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

DOBSON, POLLY. “Biocatalysis of Soybean 15-Lipoxygenase for the production of lipid mediators of Inflammation.” 2016. Web. 18 Jan 2021.

Vancouver:

DOBSON P. Biocatalysis of Soybean 15-Lipoxygenase for the production of lipid mediators of Inflammation. [Internet] [Thesis]. Deakin University; 2016. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10536/DRO/DU:30089039.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

DOBSON P. Biocatalysis of Soybean 15-Lipoxygenase for the production of lipid mediators of Inflammation. [Thesis]. Deakin University; 2016. Available from: http://hdl.handle.net/10536/DRO/DU:30089039

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Pretoria

2. [No author]. An evaluation of the anti-inflammatory activity and mechanism of action of three novel auranofin derivatives .

Degree: 2009, University of Pretoria

URL: http://upetd.up.ac.za/thesis/available/etd-02242009-160331/

► Gold compounds have been used for the treatment of rheumatoid arthritis since the mid 20th century as a disease modifying anti-rheumatic drug. Auranofin, an oral… (more)

▼ Gold compounds have been used for the treatment of rheumatoid arthritis since the mid 20th century as a disease modifying anti-rheumatic drug. Auranofin, an oral anti-rheumatic drug, has been used for many years in the treatment of rheumatoid arthritis (RA). Although the drug has been successful in treating the symptoms of RA, many patients discontinue its use due to severe toxicity over long periods of continued treatment. Since the introduction of auranofin in 1985 there has been no new clinically approved gold drug. Drug discovery research is directing focus on overcoming these toxicity problems. Much of the problems related to the toxicity related to auranofin are due to its lipophilicity. As a result, three compounds (Asa-fin, Mpta-fin and Pta-fin) with varying substituents were synthesised and hence the lipophilic- hydrophilic balance was modulated. All compounds including auranofin were tested against normal cells to determine its toxicity as well as its anti-inflammatory activity. Three novel auranofin derivatives were compared to auranofin with regards to lipophilicity, toxicity and anti-inflammatory properties The lipophilicity of the three compounds were compared to auranofin using the octanol-water partition coefficient method. All the novel compounds showed variable lipophilicity compared to auranofin, with Pta-fin and Mpta-fin being more hydrophilic than auranofin. The cytotoxicity of these novel gold compounds Asa-fin, Mpta-fin and Pta-fin were compared to auranofin using primary porcine hepatocytes and chicken embryo fibroblasts cultures. A metabolic assay based on the reactivity of 3-[4,5-dimethylyhiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) with viable cells was done to measure the effect of the drugs on the growth of cultures. All three novel compounds proved less toxicity at comparable concentrations in primary porcine hepatocytes and in fibroblast proliferation, Asa-fin and Mpta-fin proved less toxic than Auranofin. The Anti-inflammatory activity of the experimental compounds was determined by testing the effects of the experimental compounds on human lymphocyte proliferation. The MTT assay was used to measure the effect of the drugs on the growth of the cell cultures. All three compounds inhibited the proliferation of human lymphocytes with Pta-fin having the least effect. The effect of these drugs was also evaluated on the reactive oxidant production by chemiluminescence and flow cytometry on resting, N-formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP) and Phorbol Myristate Acetate (PMA) stimulated human neutrophils. Oxidant production by neutrophils was measured after a 45-minute incubation period with luminol enhanced chemiluminescence. Treatment of neutrophils with auranofin and the three compounds showed that auranofin, Asa-fin and Mpta-fin had a biphasic activity on hydrogen peroxide production with higher concentrations decreasing hydrogen peroxide production, possibly leading to the anti-inflammatory action of these drugs. With Pta-fin no decrease in hydrogen peroxide was… Advisors/Committee Members: Prof C E Medlen (advisor).

Subjects/Keywords: Anti-inflammatory; Cytotoxicity; Auranofin; UCTD

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APA (6^th Edition):

author], [. (2009). An evaluation of the anti-inflammatory activity and mechanism of action of three novel auranofin derivatives . (Masters Thesis). University of Pretoria. Retrieved from http://upetd.up.ac.za/thesis/available/etd-02242009-160331/

Chicago Manual of Style (16^th Edition):

author], [No. “An evaluation of the anti-inflammatory activity and mechanism of action of three novel auranofin derivatives .” 2009. Masters Thesis, University of Pretoria. Accessed January 18, 2021. http://upetd.up.ac.za/thesis/available/etd-02242009-160331/.

MLA Handbook (7^th Edition):

author], [No. “An evaluation of the anti-inflammatory activity and mechanism of action of three novel auranofin derivatives .” 2009. Web. 18 Jan 2021.

Vancouver:

author] [. An evaluation of the anti-inflammatory activity and mechanism of action of three novel auranofin derivatives . [Internet] [Masters thesis]. University of Pretoria; 2009. [cited 2021 Jan 18]. Available from: http://upetd.up.ac.za/thesis/available/etd-02242009-160331/.

Council of Science Editors:

author] [. An evaluation of the anti-inflammatory activity and mechanism of action of three novel auranofin derivatives . [Masters Thesis]. University of Pretoria; 2009. Available from: http://upetd.up.ac.za/thesis/available/etd-02242009-160331/

University of Pretoria

3. Rasool, Yusuf. An evaluation of the anti-inflammatory activity and mechanism of action of three novel auranofin derivatives.

Degree: Pharmacology, 2009, University of Pretoria

URL: http://hdl.handle.net/2263/22792

► Gold compounds have been used for the treatment of rheumatoid arthritis since the mid 20th century as a disease modifying anti-rheumatic drug. Auranofin, an oral… (more)

▼ Gold compounds have been used for the treatment of rheumatoid arthritis since the mid 20th century as a disease modifying anti-rheumatic drug. Auranofin, an oral anti-rheumatic drug, has been used for many years in the treatment of rheumatoid arthritis (RA). Although the drug has been successful in treating the symptoms of RA, many patients discontinue its use due to severe toxicity over long periods of continued treatment. Since the introduction of auranofin in 1985 there has been no new clinically approved gold drug. Drug discovery research is directing focus on overcoming these toxicity problems. Much of the problems related to the toxicity related to auranofin are due to its lipophilicity. As a result, three compounds (Asa-fin, Mpta-fin and Pta-fin) with varying substituents were synthesised and hence the lipophilic- hydrophilic balance was modulated. All compounds including auranofin were tested against normal cells to determine its toxicity as well as its anti-inflammatory activity. Three novel auranofin derivatives were compared to auranofin with regards to lipophilicity, toxicity and anti-inflammatory properties The lipophilicity of the three compounds were compared to auranofin using the octanol-water partition coefficient method. All the novel compounds showed variable lipophilicity compared to auranofin, with Pta-fin and Mpta-fin being more hydrophilic than auranofin. The cytotoxicity of these novel gold compounds Asa-fin, Mpta-fin and Pta-fin were compared to auranofin using primary porcine hepatocytes and chicken embryo fibroblasts cultures. A metabolic assay based on the reactivity of 3-[4,5-dimethylyhiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) with viable cells was done to measure the effect of the drugs on the growth of cultures. All three novel compounds proved less toxicity at comparable concentrations in primary porcine hepatocytes and in fibroblast proliferation, Asa-fin and Mpta-fin proved less toxic than Auranofin. The Anti-inflammatory activity of the experimental compounds was determined by testing the effects of the experimental compounds on human lymphocyte proliferation. The MTT assay was used to measure the effect of the drugs on the growth of the cell cultures. All three compounds inhibited the proliferation of human lymphocytes with Pta-fin having the least effect. The effect of these drugs was also evaluated on the reactive oxidant production by chemiluminescence and flow cytometry on resting, N-formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP) and Phorbol Myristate Acetate (PMA) stimulated human neutrophils. Oxidant production by neutrophils was measured after a 45-minute incubation period with luminol enhanced chemiluminescence. Treatment of neutrophils with auranofin and the three compounds showed that auranofin, Asa-fin and Mpta-fin had a biphasic activity on hydrogen peroxide production with higher concentrations decreasing hydrogen peroxide production, possibly leading to the anti-inflammatory action of these drugs. With Pta-fin no decrease in hydrogen peroxide was… Advisors/Committee Members: Prof C E Medlen (advisor).

Subjects/Keywords: Anti-inflammatory; Cytotoxicity; Auranofin; UCTD

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rasool, Y. (2009). An evaluation of the anti-inflammatory activity and mechanism of action of three novel auranofin derivatives. (Masters Thesis). University of Pretoria. Retrieved from http://hdl.handle.net/2263/22792

Chicago Manual of Style (16^th Edition):

Rasool, Yusuf. “An evaluation of the anti-inflammatory activity and mechanism of action of three novel auranofin derivatives.” 2009. Masters Thesis, University of Pretoria. Accessed January 18, 2021. http://hdl.handle.net/2263/22792.

MLA Handbook (7^th Edition):

Rasool, Yusuf. “An evaluation of the anti-inflammatory activity and mechanism of action of three novel auranofin derivatives.” 2009. Web. 18 Jan 2021.

Vancouver:

Rasool Y. An evaluation of the anti-inflammatory activity and mechanism of action of three novel auranofin derivatives. [Internet] [Masters thesis]. University of Pretoria; 2009. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/2263/22792.

Council of Science Editors:

Rasool Y. An evaluation of the anti-inflammatory activity and mechanism of action of three novel auranofin derivatives. [Masters Thesis]. University of Pretoria; 2009. Available from: http://hdl.handle.net/2263/22792

4. Nakka, Mamatha. Synthesis, characterization and biological activities of novel hybrid molecules related to substituted hydrazones, sulphonamides and sulphonates of non-steroidal anti inflammatory drugs; -.

Degree: Chemistry, 2011, Jawaharlal Nehru Technological University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/4496

►

CHAPTER 1 A Brief Overview of Synthesis and Pharmacological newlineActivities of Substituted Hydrazones, Sulphonates and Sulphonamides This chapter deals with general survey of the literature… (more)

▼

CHAPTER 1 A Brief Overview of Synthesis and Pharmacological newlineActivities of Substituted Hydrazones, Sulphonates and Sulphonamides This chapter deals with general survey of the literature related to the present topic which describes pharmacological importance, synthesis and the synthetic utility of substituted hydrazones, sulphonates and sulphonamides. N-acyl hydrazones which are pharmacologically important has been combined with Non-steroidal anti-inflammatory drugs such as Naproxen and Ibuprofen drugs used for the treatment of inflammation and also used as an antipyretic agents. There are conditions when an inflammation occurs in response to a microbial infection, and a combination of the anti-inflammatory drug with antimicrobial agent is prescribed in such conditions. These combinations often cause side effects because of high doses of drugs. Searching for new compounds, which would combine two activities seem to be promising way to overcome that problem. Sulfonates and sulfonamides as we know that these are the main drugs which are used as antibacterial agents. In light of theseobservations, we became interested in the synthesis, characterization and biological evaluation of hybrid molecules related to N-acyl hydrazones, sulfonates and sulfonamides. In order to assess more accurately and to provide a background frame work for the work described in this thesis, a survey was undertaken of the relevant literature. The details of synthesis and phamacological activity were presented in this chapter.CHAPTER 2 Synthesis, characterization, cytotoxic and antibacterial study of Naproxen derivatives This chapter deals with a detailed study of synthesis, characterization and cytotoxicity activity propionic acid based hybrid molecules related to Naproxen (1) and N acylhydrazones (Scheme 1). Pharmacological importance of N-acylhydrazones and the gastro intestinal side effects of Naproxen prompted us to plan the synthesis of new derivatives containing both the skeletons.

References given chapters wise, Summary p.287-301

Advisors/Committee Members: Mukkanti, K.

Subjects/Keywords: anti inflammatory drugs; Chemistry

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APA (6^th Edition):

Nakka, M. (2011). Synthesis, characterization and biological activities of novel hybrid molecules related to substituted hydrazones, sulphonamides and sulphonates of non-steroidal anti inflammatory drugs; -. (Thesis). Jawaharlal Nehru Technological University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/4496

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Nakka, Mamatha. “Synthesis, characterization and biological activities of novel hybrid molecules related to substituted hydrazones, sulphonamides and sulphonates of non-steroidal anti inflammatory drugs; -.” 2011. Thesis, Jawaharlal Nehru Technological University. Accessed January 18, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/4496.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Nakka, Mamatha. “Synthesis, characterization and biological activities of novel hybrid molecules related to substituted hydrazones, sulphonamides and sulphonates of non-steroidal anti inflammatory drugs; -.” 2011. Web. 18 Jan 2021.

Vancouver:

Nakka M. Synthesis, characterization and biological activities of novel hybrid molecules related to substituted hydrazones, sulphonamides and sulphonates of non-steroidal anti inflammatory drugs; -. [Internet] [Thesis]. Jawaharlal Nehru Technological University; 2011. [cited 2021 Jan 18]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/4496.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Nakka M. Synthesis, characterization and biological activities of novel hybrid molecules related to substituted hydrazones, sulphonamides and sulphonates of non-steroidal anti inflammatory drugs; -. [Thesis]. Jawaharlal Nehru Technological University; 2011. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/4496

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

5. Wang, Chenxuan 1991-. Cytoprotective Roles of Oat Avenathramides Against Inflammation and Cellular Stress.

Degree: 2018, University of Saskatchewan

URL: http://hdl.handle.net/10388/9654

► Natural polyphenols have been considered as promising anti-aging compounds not only for their antioxidant activity, many of them also function as signaling mediators that modulate… (more)

▼ Natural polyphenols have been considered as promising anti-aging compounds not only for their antioxidant activity, many of them also function as signaling mediators that modulate cellular pathways involved in cytoprotection. Avenanthramides (Avns), a group of polyphenols found exclusively in oats, are natural antioxidants associated with human health promotion. In this study, avenanthramide A, B and C (Avn A, B and C), the three most abundant Avns in oats, were identified and quantified from oat phenolic-rich extracts of ten oat varieties. In addition, in vitro antioxidant activities of oat extracts and Avn A, B and C were evaluated. It was found that Avn C had the highest in vitro antioxidant activity among the three Avns. To investigate the cytoprotective activity of Avn C, normal human skin fibroblasts (2DD) were treated with Avn C followed by exposure to extracellular stress and its ability to reduce cellular damage was determined. Pre-treatment of cells with Avn C reduced hydrogen peroxide (H2O2)-induced oxidative stress significantly as demonstrated by decreased intracellular free radical levels and antioxidant gene transcripts. Avn C pre-treatment also resulted in decreased levels of gene transcripts encoding pro-inflammatory cytokines in response to H2O2 or tumor necrosis factor α (TNF-α) stimulation. This reduction in cytokine gene transcription occurred concomitantly with reduced phosphorylated nuclear factor-κB (NF-κB) p65, indicating reduced pro-inflammatory response. To better understand the mechanisms of actions, the impact of Avn C on cellular signaling pathways was investigated on Avn C-treated 2DD cells without exposure to stress. We found that Avn C induced heme oxygenase-1 (HO-1) expression through increased DNA-Nrf2 binding activity. Also, it reduced basal levels of pro-inflammatory cytokines through decreased DNA-NF-κB binding activity. Those mechanism pathways are independent of free radical scavenging and strongly associated with oxidation, inflammation and the aging process. Moreover, anti-proliferative effect of Avn C on 2DD cells was observed via mechanisms independent of autophagy activation. Collectively, our findings suggest that Avn C protects normal human skin fibroblasts against oxidative stress and inflammatory response through Nrf2/HO-1 activation and NF-κB inhibition and further imply that Avn C may be a potential nutraceutical for health promotion and disease prevention. Advisors/Committee Members: Eskiw, Christopher, Qiu, Xiao, Tanaka, Takuji, Low, Nicholas, Yang, Jian.

Subjects/Keywords: Avenathramide C; Antioxidant; Anti-inflammatory

10 more images…

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APA (6^th Edition):

Wang, C. 1. (2018). Cytoprotective Roles of Oat Avenathramides Against Inflammation and Cellular Stress. (Thesis). University of Saskatchewan. Retrieved from http://hdl.handle.net/10388/9654

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wang, Chenxuan 1991-. “Cytoprotective Roles of Oat Avenathramides Against Inflammation and Cellular Stress.” 2018. Thesis, University of Saskatchewan. Accessed January 18, 2021. http://hdl.handle.net/10388/9654.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wang, Chenxuan 1991-. “Cytoprotective Roles of Oat Avenathramides Against Inflammation and Cellular Stress.” 2018. Web. 18 Jan 2021.

Vancouver:

Wang C1. Cytoprotective Roles of Oat Avenathramides Against Inflammation and Cellular Stress. [Internet] [Thesis]. University of Saskatchewan; 2018. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10388/9654.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wang C1. Cytoprotective Roles of Oat Avenathramides Against Inflammation and Cellular Stress. [Thesis]. University of Saskatchewan; 2018. Available from: http://hdl.handle.net/10388/9654

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Wake Forest University

6. West-Livingston, Lauren Nicole. Development of a Multifunctionalized Vascular Scaffolding System to Induce In Situ Endothelial Cell Capture, Smooth Muscle Cell Migration, and Prevention of Inflammatory Cell Infiltration.

Degree: 2020, Wake Forest University

URL: http://hdl.handle.net/10339/96825

► Cardiovascular disease (CVD) is the leading cause of death globally, and is responsible for innumerable complications related to the peripheral vascular system. Peripheral vascular disease… (more)

Subjects/Keywords: Anti-Inflammatory Drug Loading

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APA (6^th Edition):

West-Livingston, L. N. (2020). Development of a Multifunctionalized Vascular Scaffolding System to Induce In Situ Endothelial Cell Capture, Smooth Muscle Cell Migration, and Prevention of Inflammatory Cell Infiltration. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/96825

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

West-Livingston, Lauren Nicole. “Development of a Multifunctionalized Vascular Scaffolding System to Induce In Situ Endothelial Cell Capture, Smooth Muscle Cell Migration, and Prevention of Inflammatory Cell Infiltration.” 2020. Thesis, Wake Forest University. Accessed January 18, 2021. http://hdl.handle.net/10339/96825.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

West-Livingston, Lauren Nicole. “Development of a Multifunctionalized Vascular Scaffolding System to Induce In Situ Endothelial Cell Capture, Smooth Muscle Cell Migration, and Prevention of Inflammatory Cell Infiltration.” 2020. Web. 18 Jan 2021.

Vancouver:

West-Livingston LN. Development of a Multifunctionalized Vascular Scaffolding System to Induce In Situ Endothelial Cell Capture, Smooth Muscle Cell Migration, and Prevention of Inflammatory Cell Infiltration. [Internet] [Thesis]. Wake Forest University; 2020. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10339/96825.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

West-Livingston LN. Development of a Multifunctionalized Vascular Scaffolding System to Induce In Situ Endothelial Cell Capture, Smooth Muscle Cell Migration, and Prevention of Inflammatory Cell Infiltration. [Thesis]. Wake Forest University; 2020. Available from: http://hdl.handle.net/10339/96825

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of KwaZulu-Natal

7. Nkosi, Makhipha Johannes. Pharmacoeconomic implications of interchangeable use of oral NSAIDS for pain management at a district hospital.

Degree: 2015, University of KwaZulu-Natal

URL: http://hdl.handle.net/10413/14951

► Background: Ibuprofen, diclofenac and aspirin belong to the same class of drugs called NSAIDs, but are used interchangeably at Tonga Hospital. The problem with this… (more)

▼ Background: Ibuprofen, diclofenac and aspirin belong to the same class of drugs called NSAIDs, but are used interchangeably at Tonga Hospital. The problem with this approach is that it may lead to preventable misguided and increased spending on pharmaceuticals. Aim: To investigate the pharmacoeconomic implications of interchangeable use of oral NSAIDs for pain management at a district hospital. Setting: This study was conducted at a district hospital in the Tonga village in the Nkomazi municipality, Mpumalanga Province, South Africa. Methods: A quantitative retrospective descriptive study, using existing patient records as well as medicine stock control records, was conducted to investigate the cost-effectiveness of oral NSAIDs when used interchangeably in the management of pain in adult patients at a district hospital. Results: The total number of patients included in this study was 211 in a split of 104 in 2013 and 107 in 2014. The mean ages of all the patients who participated in our study in 2013 and 2014 were 36 and 35 years respectively and there were more females than males. Most patients who presented at Tonga Hospital for pain management were suffering from minor bodily/joint pains (36.0%, n=76), whereas the least number of patients were suffering from bone fractures (10.9%, n=23). Our study found that most patients (31.3%; n=66) treated with ibuprofen were suffering from minor bodily/joint pains, whereas the least number of patients (1.4%; n=3) treated with diclofenac were suffering from inflammatory conditions. Females were the largest users of NSAIDs (both ibuprofen and diclofenac) in Tonga Hospital when compared with males. Patients between the ages of 19-35 years were the most prevalent (28.4%, n=60) who were treated with ibuprofen when compared with patients 18 years and below (9.5%, n=20). Also, patients who were 18 years and younger and treated with diclofenac were the least number of patients (1.4%, n=3). The highest total NSAID stock volumes issued from July to December of 2013 and 2014 combined was ibuprofen (36978 packs) when compared with diclofenac (11127 packs). The stock volumes for both ibuprofen and diclofenac were higher in July, with 8170 for Ibuprofen and 2099 for diclofenac. Diclofenac stock volumes fell to their lowest (1583) in September, whereas Ibuprofen stock volumes fell to their lowest (4478) in December. The fall in stock volumes issued might be attributable to many factors including but not limited to non-delivery by the supplier or non-ordering by the pharmacy staff. In all instances ibuprofen stock volumes issued were higher than that of diclofenac. The acquisition cost of ibuprofen when calculated as mean price per tablet during 2013 to 2014 was consistently lower, with an average price of (0.285 ZAR) when compared with diclofenac (0.995 ZAR). 0.3% of the population of Nkomazi east, on average, gets treatment of ibuprofen daily whereas 0.01% of the population gets treatment of diclofenac daily. The mean cost per defined daily dose was… Advisors/Committee Members: Mathibe, Lehlohonolo J. (advisor).

Subjects/Keywords: Anti-inflammatory agent.; NSAIDS pharmacology.

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APA (6^th Edition):

Nkosi, M. J. (2015). Pharmacoeconomic implications of interchangeable use of oral NSAIDS for pain management at a district hospital. (Thesis). University of KwaZulu-Natal. Retrieved from http://hdl.handle.net/10413/14951

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Nkosi, Makhipha Johannes. “Pharmacoeconomic implications of interchangeable use of oral NSAIDS for pain management at a district hospital.” 2015. Thesis, University of KwaZulu-Natal. Accessed January 18, 2021. http://hdl.handle.net/10413/14951.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Nkosi, Makhipha Johannes. “Pharmacoeconomic implications of interchangeable use of oral NSAIDS for pain management at a district hospital.” 2015. Web. 18 Jan 2021.

Vancouver:

Nkosi MJ. Pharmacoeconomic implications of interchangeable use of oral NSAIDS for pain management at a district hospital. [Internet] [Thesis]. University of KwaZulu-Natal; 2015. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10413/14951.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Nkosi MJ. Pharmacoeconomic implications of interchangeable use of oral NSAIDS for pain management at a district hospital. [Thesis]. University of KwaZulu-Natal; 2015. Available from: http://hdl.handle.net/10413/14951

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

8. Bebal, Brenda. The Effects of Curcumin Treatment for Arthritis in Decreasing Inflammation: A Systematic Review .

Degree: 2015, California State University – San Marcos

URL: http://hdl.handle.net/10211.3/140891

► Statement of Problem Persons who suffer from arthritis have chronic and extensive inflammation, pain and joint damage. Current conventional pharmacological treatment halts the progression of… (more)

Subjects/Keywords: Curcumin; Curcuma longa; Anti- inflammatory

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APA (6^th Edition):

Bebal, B. (2015). The Effects of Curcumin Treatment for Arthritis in Decreasing Inflammation: A Systematic Review . (Thesis). California State University – San Marcos. Retrieved from http://hdl.handle.net/10211.3/140891

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bebal, Brenda. “The Effects of Curcumin Treatment for Arthritis in Decreasing Inflammation: A Systematic Review .” 2015. Thesis, California State University – San Marcos. Accessed January 18, 2021. http://hdl.handle.net/10211.3/140891.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bebal, Brenda. “The Effects of Curcumin Treatment for Arthritis in Decreasing Inflammation: A Systematic Review .” 2015. Web. 18 Jan 2021.

Vancouver:

Bebal B. The Effects of Curcumin Treatment for Arthritis in Decreasing Inflammation: A Systematic Review . [Internet] [Thesis]. California State University – San Marcos; 2015. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10211.3/140891.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bebal B. The Effects of Curcumin Treatment for Arthritis in Decreasing Inflammation: A Systematic Review . [Thesis]. California State University – San Marcos; 2015. Available from: http://hdl.handle.net/10211.3/140891

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Rutgers University

9. Wang, Siyu, 1991-. Hydroxycinnamic acid amides from Lycium barbarum and their anti-inflammatory mechanisms.

Degree: PhD, Food Science, 2018, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/59270/

► Over the past few decades, much research has identified chronic inflammation as a critical component in many human diseases. Due to the intimate relationship between… (more)

▼ Over the past few decades, much research has identified chronic inflammation as a critical component in many human diseases. Due to the intimate relationship between chronic inflammation and human diseases and conditions, an accumulating number of studies aimed to identify and discover anti-inflammatory molecules from natural resources because these molecules are able to interact with inflammatory mediators as well as modulate inflammatory pathways. Hydroxycinnamic acid amides (HCAA) are the secondary metabolites ubiquitously exist in flowering plants, formed by condensation between hydroxycinnamates and mono or polyamines. HCAA species not only serve multiple functions in plant growth and development, but also exert significant positive effects on human health. HCAA family has been recognized as the most characteristic and abundant chemical species of Lycium barbarum. The plant has been recognized as traditional remedies for hyperglycemia and other health conditions. Wolfberry or Goji berry, the fruits of Lycium barbarum, are widely consumed in Asian cuisine due to their health-promoting properties. In the first part of my work, we synthesized a set of HCAA compounds, including trans-caffeic acid, trans-ferulic acid, and 3,4-dihydroxyhydrocinnamic acid, with extended phenolic amine components as standards to identify and quantify the corresponding compounds from different parts of Lycium barbarum. With optimized LC–MS/MS and NMR analysis, nine amide compounds were identified from the fruits, and 10 new HCAA species were further identified in root barks in addition to the ones reported in the literature. HCAA species were reported in leaves for the first time. The quantification showed the amide compounds with a tyramine moiety were the most abundant. Moreover, the method was fully validated with respect to specificity, linearity, intra- and inter-day precision and accuracy, limit of detection (LOD), limit of quantification (LOQ), recovery, and reproducibility. The anti-inflammatory properties of identified HCAAs were also examined by nitric oxide (NO) inhibition assay. Seven HCAA compounds had a potent NO inhibitory effect with IC50 as low as 2.381 μM (trans-N-caffeoyl phenethylamine). Two HCAA compounds (trans-N-caffeoyl tryptamine and trans-N-caffeoyl tyramine) were chosen to investigate their anti-inflammatory molecular mechanisms by both in vitro and in vivo assays. These two HCAAs inhibited NF-κB signaling pathway in murine macrophage RAW264.7, accompanied by inhibition of PI3K/Akt/IKK pathway. In vivo mouse ear edema model indicated that with treatment of the two HCAAs, TPA-induced ear edema was significant reduced by showing as reduction of ear weight and thickness, pro-inflammatory enzyme expression as well as immune cells infiltration. The developed analytical method largely improved analytical sensitivity of HCAAs species that potentially contributes to plant metabolomics and drug discovery studies. HCAAs demonstrated promising anti-inflammatory properties that could be used as preventive agent for… Advisors/Committee Members: HO, CHI-TANG (chair), Wu, Qing-Li (internal member), HUANG, QINGRONG (internal member), Wang, Yu (outside member), School of Graduate Studies.

Subjects/Keywords: Plant metabolites; Anti-inflammatory agents

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APA (6^th Edition):

Wang, Siyu, 1. (2018). Hydroxycinnamic acid amides from Lycium barbarum and their anti-inflammatory mechanisms. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/59270/

Chicago Manual of Style (16^th Edition):

Wang, Siyu, 1991-. “Hydroxycinnamic acid amides from Lycium barbarum and their anti-inflammatory mechanisms.” 2018. Doctoral Dissertation, Rutgers University. Accessed January 18, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/59270/.

MLA Handbook (7^th Edition):

Wang, Siyu, 1991-. “Hydroxycinnamic acid amides from Lycium barbarum and their anti-inflammatory mechanisms.” 2018. Web. 18 Jan 2021.

Vancouver:

Wang, Siyu 1. Hydroxycinnamic acid amides from Lycium barbarum and their anti-inflammatory mechanisms. [Internet] [Doctoral dissertation]. Rutgers University; 2018. [cited 2021 Jan 18]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/59270/.

Council of Science Editors:

Wang, Siyu 1. Hydroxycinnamic acid amides from Lycium barbarum and their anti-inflammatory mechanisms. [Doctoral Dissertation]. Rutgers University; 2018. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/59270/

Rutgers University

10. Hsieh, Pei-Hsuan, 1988-. Anti-inflammatory effect of resveratrol metabolite, δ-viniferin, on lipopolysaccharide-stimulated murine macrophage.

Degree: MS, Food Science, 2016, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/49239/

► Inflammation is a complicated physiological and pathological process in response to stimuli. In general, a controlled inflammatory response is a beneficial defense system, which provides… (more)

▼ Inflammation is a complicated physiological and pathological process in response to stimuli. In general, a controlled inflammatory response is a beneficial defense system, which provides protection against infection. However, it can become detrimental when the response is prolonged and dysregulated called chronic inflammation. Over the past several years, chronic inflammation has been recognized to be the root of various human diseases, including neurological disorders, metabolic disorders, obesity, cardiovascular diseases and cancers. Resveratrol is a well-known natural antioxidative and anti-inflammatory compound from grapes. In the previous study, the antioxidative properties of resveratrol metabolites have been suggested to be more active than resveratrol. δ-Viniferin is a main resveratrol dehydrodimer metabolite and has been identified in grape cell cultures and wines. It possesses two resorcinol skeletons, which are determinants of radical scavenging and antioxidative potential. Hence, we researched in the anti-inflammatory effect of δ-viniferin. We prepared this compound in vitro by the oxidative dimerization of resveratrol with horseradish peroxidase in the presence of H2O2. In this study, the cytotoxic and anti-inflammatory effects on LPS-stimulated murine macrophage were examined. According to the data, we found that δ-viniferin suppressed the levels of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and phosphorylated inhibitor κBα (p-IκBα) protein expressions, as well as the down-stream product, nitric oxide, in murine RAW 264.7 cells induced with lipopolysaccharide (LPS). Moreover, the inhibitory effects of δ-viniferin on inflammation associated signaling pathways, such as the blockade of LPS-induced IκBα phosphorylation and degradation, the decrease of PI3K and Akt phosphorylation, and the reduction of LPS-induced transcriptional activity of NF-κB. According to the results, δ-viniferin might have potential to be developed into an effective anti-inflammatory agent. Advisors/Committee Members: HO, CHI-TANG (chair), Hartman, Thomas G (internal member), HUANG, QINGRONG (internal member).

Subjects/Keywords: Anti-inflammatory agents; Resveratrol; Inflammation

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APA (6^th Edition):

Hsieh, Pei-Hsuan, 1. (2016). Anti-inflammatory effect of resveratrol metabolite, δ-viniferin, on lipopolysaccharide-stimulated murine macrophage. (Masters Thesis). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/49239/

Chicago Manual of Style (16^th Edition):

Hsieh, Pei-Hsuan, 1988-. “Anti-inflammatory effect of resveratrol metabolite, δ-viniferin, on lipopolysaccharide-stimulated murine macrophage.” 2016. Masters Thesis, Rutgers University. Accessed January 18, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/49239/.

MLA Handbook (7^th Edition):

Hsieh, Pei-Hsuan, 1988-. “Anti-inflammatory effect of resveratrol metabolite, δ-viniferin, on lipopolysaccharide-stimulated murine macrophage.” 2016. Web. 18 Jan 2021.

Vancouver:

Hsieh, Pei-Hsuan 1. Anti-inflammatory effect of resveratrol metabolite, δ-viniferin, on lipopolysaccharide-stimulated murine macrophage. [Internet] [Masters thesis]. Rutgers University; 2016. [cited 2021 Jan 18]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/49239/.

Council of Science Editors:

Hsieh, Pei-Hsuan 1. Anti-inflammatory effect of resveratrol metabolite, δ-viniferin, on lipopolysaccharide-stimulated murine macrophage. [Masters Thesis]. Rutgers University; 2016. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/49239/

NSYSU

11. Wen, Yi-shan. An anti-inflammatory activity of marine-derived compound for cosmeceutical use.

Degree: Master, Marine Biotechnology and Resources, 2013, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0716113-162938

► Most Asians consider fair skin to be a key element of beauty. According to market statistics (source: Euromonitor International), in 2012, cosmetics accounted for a… (more)

▼ Most Asians consider fair skin to be a key element of beauty. According to market statistics (source: Euromonitor International), in 2012, cosmetics accounted for a revenue of more than $430 billion in global markets. Some of these cosmetics are used for purposes other than beauty; âcosmeceuticalâ applications can be utilized for functions or mechanisms to soothe skin conditions. For example: postinflammatory hyperpigmentation, which usually accompanies disorders associated with melanogenesis, is caused by dermatological diseases such as contact dermatitis and atopic dermatitis or by skin damage due to UV exposure. Some of the widely used skin-whitening agents in cosmetic products or for hyperpigmentation diseases, such as hydroquinone and arbutin, are toxic and, hence, have their limitations. Findings of our preliminary anti-inflammatory screening procedure showed that a marine-derived compound significantly inhibited the expression of lipopolysaccharide-induced proinflammatory protein iNOS in murine macrophage-like RAW264.7 cells. The aim of this study was to find a safer and more effective compound than those currently in use, with anti-inflammatory, anti-melanogenic or other applicable properties for future cosmeceutical or medical use. Our results indicated that the marine-derived compound could effectively inhibit pigmentation likely by the potential downregulation of tyrosinase activity; furthermore, the compound also demonstrated low cytotoxic effect dose on B16-F10 murine melanoma cells. We also found that the marine-derived compound could suppress melanin formation while sustaining delivery treatment in the zebrafish model, without having any toxic effects. Results of our in vitro and in vivo biological assays showed that the synthetic marine-derived compound possesses anti-inflammatory, anti-melanogenic and anti-oxidative properties, with potential application in medical cosmetology. Advisors/Committee Members: Zhi-Hong, Wen (committee member), Chang-Yi, Wu (chair), Hui-Min, Wang (chair).

Subjects/Keywords: melanin; anti-inflammatory; anti-melanogenic; zebrafish; tyrosinase

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APA (6^th Edition):

Wen, Y. (2013). An anti-inflammatory activity of marine-derived compound for cosmeceutical use. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0716113-162938

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wen, Yi-shan. “An anti-inflammatory activity of marine-derived compound for cosmeceutical use.” 2013. Thesis, NSYSU. Accessed January 18, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0716113-162938.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wen, Yi-shan. “An anti-inflammatory activity of marine-derived compound for cosmeceutical use.” 2013. Web. 18 Jan 2021.

Vancouver:

Wen Y. An anti-inflammatory activity of marine-derived compound for cosmeceutical use. [Internet] [Thesis]. NSYSU; 2013. [cited 2021 Jan 18]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0716113-162938.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wen Y. An anti-inflammatory activity of marine-derived compound for cosmeceutical use. [Thesis]. NSYSU; 2013. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0716113-162938

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade Estadual de Campinas

12. Lazarini, Josy Goldoni, 1990-. Phytochemical, toxicity, and evaluation of anti-inflammatory and antioxidant activities of "Eugenia neonitida" Sobral (pitangatuba), a Brazilian native fruit : Fitoquímica, toxicidade e avaliação das atividades anti-inflamatória e antioxidante de "Eugenia neonitida" Sobral (pitangatuba), uma fruta nativa do Brasil: Fitoquímica, toxicidade e avaliação das atividades anti-inflamatória e antioxidante de "Eugenia neonitida" Sobral (pitangatuba), uma fruta nativa do Brasil.

Degree: 2020, Universidade Estadual de Campinas

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/339609

► Abstract: Brazilian native fruits (FNB) can be classified as "superfruits" due to their rich polyphenolic composition that can modulate the inflammatory process as well as… (more)

▼ Abstract: Brazilian native fruits (FNB) can be classified as "superfruits" due to their rich polyphenolic composition that can modulate the inflammatory process as well as reduce the production of reactive oxygen and nitrogen species (ROS/RNS). This study determined the polyphenolic composition, evaluated the mechanism of anti-inflammatory action, antioxidant activity and systemic toxicity profile of the extract, fraction (F3) and subfraction (S8) of Eugenia neonitida (Ene). The compounds present in Ene, F3, and S8 were quantified and identified by LC-ESI-QTOF-MS. For the studies of anti-inflammatory activity in vitro, RAW 264.7 macrophages (NF-kB-pLUC gene) transfected were used stimulated with LPS and quantification of inflammatory cytokines by ELISA. For the evaluation of the anti-inflammatory mechanism of action in vivo, neutrophil migration tests were performed in the peritoneal cavity of mice challenged with carrageenan, quantification of inflammatory cytokines in vivo using ELISA, intravital microscopy (rolling and leukocyte adhesion) and expression of adhesion molecule (ICAM-1) by Western Blotting. For antioxidant activity, tests against ROS/RNS (ROO, O2 -, HOCl and NO ) were used. Finally, the systemic toxicity profile was tested in Galleria mellonella larvae. Chemical analysis revealed the presence of hydroxybenzoic acid, flavanoids and ellagitannins for Ene and F3 and derivatives of quercetrin, vanillic acid and cumaric acid for S8. Ene reduced the activation of NF-kB and TNF-'alfa' levels in vitro, however, it did not reduce CXCL2/MIP-2; Ene treated in vivo decreased neutrophil migration as well as TNF-'alfa' and CXCL2/MIP-2 levels. Regarding the fraction, F3 reduced the activation of NF-kB, the levels of TNF-'alfa' and CXCL2 / MIP-2 (in vitro and in vivo) and migration of neutrophils. Finally, S8 reduced activation of NF-kB, levels of TNF-'alfa' and CXCL2 / MIP-2 (in vitro and in vivo) and neutrophil migration confirmed by intravital microscopy and reduced expression of ICAM-1 (adhesion molecule) in endothelium. In general, Ene, F3 and S8 exhibited activities against ROS/RNS and none of the samples induced systemic toxicity in G. mellonella. Thus, Ene, F3 and S8 showed no toxicity and exibited anti-inflammatory and antioxidant activities due to their phenolic composition. E. neonitida is a promising source of bioactive compounds little explored, which can favor sectors such as food industries, pharmaceutical and agribusiness, providing the development of new products for human health Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Rosalen, Pedro Luiz, 1960- (advisor), Franchin, Marcelo, 1987- (coadvisor), Universidade Estadual de Campinas. Faculdade de Odontologia de Piracicaba (institution), Programa de Pós-Graduação em Odontologia (nameofprogram), Souza, Ana Paula de (committee member), Dias, Patricia Correa (committee member), Ikegaki, Masaharu (committee member), Tavassi, Ana Marisa Chudzinski (committee member).

Subjects/Keywords: Anti-inflamatórios; Antioxidantes; Anti-inflammatory agents; Antioxidants

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APA (6^th Edition):

Lazarini, Josy Goldoni, 1. (2020). Phytochemical, toxicity, and evaluation of anti-inflammatory and antioxidant activities of "Eugenia neonitida" Sobral (pitangatuba), a Brazilian native fruit : Fitoquímica, toxicidade e avaliação das atividades anti-inflamatória e antioxidante de "Eugenia neonitida" Sobral (pitangatuba), uma fruta nativa do Brasil: Fitoquímica, toxicidade e avaliação das atividades anti-inflamatória e antioxidante de "Eugenia neonitida" Sobral (pitangatuba), uma fruta nativa do Brasil. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/339609

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lazarini, Josy Goldoni, 1990-. “Phytochemical, toxicity, and evaluation of anti-inflammatory and antioxidant activities of "Eugenia neonitida" Sobral (pitangatuba), a Brazilian native fruit : Fitoquímica, toxicidade e avaliação das atividades anti-inflamatória e antioxidante de "Eugenia neonitida" Sobral (pitangatuba), uma fruta nativa do Brasil: Fitoquímica, toxicidade e avaliação das atividades anti-inflamatória e antioxidante de "Eugenia neonitida" Sobral (pitangatuba), uma fruta nativa do Brasil.” 2020. Thesis, Universidade Estadual de Campinas. Accessed January 18, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/339609.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lazarini, Josy Goldoni, 1990-. “Phytochemical, toxicity, and evaluation of anti-inflammatory and antioxidant activities of "Eugenia neonitida" Sobral (pitangatuba), a Brazilian native fruit : Fitoquímica, toxicidade e avaliação das atividades anti-inflamatória e antioxidante de "Eugenia neonitida" Sobral (pitangatuba), uma fruta nativa do Brasil: Fitoquímica, toxicidade e avaliação das atividades anti-inflamatória e antioxidante de "Eugenia neonitida" Sobral (pitangatuba), uma fruta nativa do Brasil.” 2020. Web. 18 Jan 2021.

Vancouver:

Lazarini, Josy Goldoni 1. Phytochemical, toxicity, and evaluation of anti-inflammatory and antioxidant activities of "Eugenia neonitida" Sobral (pitangatuba), a Brazilian native fruit : Fitoquímica, toxicidade e avaliação das atividades anti-inflamatória e antioxidante de "Eugenia neonitida" Sobral (pitangatuba), uma fruta nativa do Brasil: Fitoquímica, toxicidade e avaliação das atividades anti-inflamatória e antioxidante de "Eugenia neonitida" Sobral (pitangatuba), uma fruta nativa do Brasil. [Internet] [Thesis]. Universidade Estadual de Campinas; 2020. [cited 2021 Jan 18]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/339609.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lazarini, Josy Goldoni 1. Phytochemical, toxicity, and evaluation of anti-inflammatory and antioxidant activities of "Eugenia neonitida" Sobral (pitangatuba), a Brazilian native fruit : Fitoquímica, toxicidade e avaliação das atividades anti-inflamatória e antioxidante de "Eugenia neonitida" Sobral (pitangatuba), uma fruta nativa do Brasil: Fitoquímica, toxicidade e avaliação das atividades anti-inflamatória e antioxidante de "Eugenia neonitida" Sobral (pitangatuba), uma fruta nativa do Brasil. [Thesis]. Universidade Estadual de Campinas; 2020. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/339609

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Sul

13. Boligon, Caroline Schardong. Spirulina platensis e marcadores inflamatórios em humanos : uma revisão sistemática.

Degree: 2015, Universidade do Rio Grande do Sul

URL: http://hdl.handle.net/10183/132154

►

Objetivo: revisar sistematicamente os efeitos da Spirulina platensis em marcadores inflamatórios em humanos. Métodos: foi realizada busca por ensaios clínicos randomizados, realizados em humanos adultos… (more)

▼

Objetivo: revisar sistematicamente os efeitos da Spirulina platensis em marcadores inflamatórios em humanos. Métodos: foi realizada busca por ensaios clínicos randomizados, realizados em humanos adultos com o objetivo de verificar os efeitos da Spirulina Platensis sob marcadores inflamatórios. A busca foi efetuada até outubro de 2015 nas bases de dados Medline via Pubmed, Cochrane Central, Clinical Trials, Scielo, LILACS, banco de teses da CAPES, assim como em bancos de grey literature. Resultados: Identificados vinte e oito estudos dos quais foram elegíveis três ensaios clínicos randomizados. A amostra foi constituída de 34 a 78 participantes, de ambos os sexos, com idade variando de 18 a 87 anos. Os marcadores inflamatórios avaliados foram: IL-2, IL-6, e TNF- e a intervenção foi feita com cápsulas de Spirulina platensis versus placebo. A IL-2 foi avaliada em dois estudos porém, não foi possível realizar a metanálise, pois um dos artigos não descrevia os valores encontrados em seu grupo controle. A IL-6 ao ser analisada em conjunto, não demonstrou diferença significativa com o uso da Spirulina platensis [-0,36 (IC95%: -0,90 a 0,18), com I2=0%]. Quanto ao TNF- não houve diferença significativa com o uso da Spirulina platensis [-0,03 (IC95%: -0,42 a 0,37)] com teste de inconsistência mostrando moderada heterogeneidade e insignificância estatística [I2= 31%, P= 0,23]. Conclusão: A informação disponível sobre o tema proposto é escassa e o efeito da Spirulina platensis sobre os marcadores inflamatórios se mostrou inconsistente. Ensaios clínicos randomizados adicionais com maior número de participantes e melhores avaliações dos marcadores são necessários para verificar o real papel anti-inflamatório da Spirulina platensis.

Objective: Perform a systematic review on the anti-inflammatory effects of Spirulina platensis in humans. Methods: A search was conducted in Medline via PubMed, Cochrane Central and Clinical Trials until October 2015 and dissertations published in CAPES, and gray literature banks for randomized controlled trials performed in adults to assess the anti-inflammatory effects of Spirulina platensis. Results: The search identified twenty eight articles. Only three randomized clinical trials were elegible for this study. The sample ranged between 34 and 78 participants, both genders, with the age ranged from 18 to 78 years. The measurements of inflammatory outcome were assessed through IL-2, IL-6, and TNF-. The intervention was capsules of Spirulina platensis versus placebo. The IL-2 was evaluated in two studies but it was not possible to evaluate the results together through meta-analysis because one of the articles did not describe the values in the control group. IL-6, when analyzed together, showed no significant difference between Spirulina platensis and placebo [-0.36 (95% CI: -0.90 to 0.18), with I2 = 0%]. Regarding the TNF- no significant difference was found [-0.03 (95% CI: -0.42 to 0.37)]. The inconsistency test showed moderate heterogeneity and no statistical significance [I2 = 31%, P =…

Advisors/Committee Members: Fagundes, Renato Borges.

Subjects/Keywords: Spirulina platensis; Anti-inflamatórios; Spirulina; Anti-inflammatory; Inflammatory markers

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APA (6^th Edition):

Boligon, C. S. (2015). Spirulina platensis e marcadores inflamatórios em humanos : uma revisão sistemática. (Thesis). Universidade do Rio Grande do Sul. Retrieved from http://hdl.handle.net/10183/132154

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Boligon, Caroline Schardong. “Spirulina platensis e marcadores inflamatórios em humanos : uma revisão sistemática.” 2015. Thesis, Universidade do Rio Grande do Sul. Accessed January 18, 2021. http://hdl.handle.net/10183/132154.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Boligon, Caroline Schardong. “Spirulina platensis e marcadores inflamatórios em humanos : uma revisão sistemática.” 2015. Web. 18 Jan 2021.

Vancouver:

Boligon CS. Spirulina platensis e marcadores inflamatórios em humanos : uma revisão sistemática. [Internet] [Thesis]. Universidade do Rio Grande do Sul; 2015. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10183/132154.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Boligon CS. Spirulina platensis e marcadores inflamatórios em humanos : uma revisão sistemática. [Thesis]. Universidade do Rio Grande do Sul; 2015. Available from: http://hdl.handle.net/10183/132154

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

14. Lin, Chi-Jui. The study on anti-inflammatory effects of the extract from Nannochloropsis oculata.

Degree: Master, Marine Biotechnology and Resources, 2014, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0522114-222924

► New bioactive compounds in microalgae increase their commercial values for healthy food. Nannochloropsis oculata is mostly used for juvenile feed, while application for health is… (more)

Subjects/Keywords: Nannochloropsis oculata; anti-inflammatory; iNOS; COX-2

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APA (6^th Edition):

Lin, C. (2014). The study on anti-inflammatory effects of the extract from Nannochloropsis oculata. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0522114-222924

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lin, Chi-Jui. “The study on anti-inflammatory effects of the extract from Nannochloropsis oculata.” 2014. Thesis, NSYSU. Accessed January 18, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0522114-222924.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lin, Chi-Jui. “The study on anti-inflammatory effects of the extract from Nannochloropsis oculata.” 2014. Web. 18 Jan 2021.

Vancouver:

Lin C. The study on anti-inflammatory effects of the extract from Nannochloropsis oculata. [Internet] [Thesis]. NSYSU; 2014. [cited 2021 Jan 18]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0522114-222924.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lin C. The study on anti-inflammatory effects of the extract from Nannochloropsis oculata. [Thesis]. NSYSU; 2014. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0522114-222924

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

15. Wu, Meng-shan. The effects of anti-inflammatory marine compound on dermatology disorders.

Degree: Master, Marine Biotechnology and Resources, 2016, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0223116-110613

► Skin is a mechanical and a chemical barrier against the invasion of pathogens. In addition, skin also plays an important role in the secretion, temperature… (more)

Subjects/Keywords: Burn; Anti-inflammatory; Angiogenesis; Atopic dermatitis

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APA (6^th Edition):

Wu, M. (2016). The effects of anti-inflammatory marine compound on dermatology disorders. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0223116-110613

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wu, Meng-shan. “The effects of anti-inflammatory marine compound on dermatology disorders.” 2016. Thesis, NSYSU. Accessed January 18, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0223116-110613.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wu, Meng-shan. “The effects of anti-inflammatory marine compound on dermatology disorders.” 2016. Web. 18 Jan 2021.

Vancouver:

Wu M. The effects of anti-inflammatory marine compound on dermatology disorders. [Internet] [Thesis]. NSYSU; 2016. [cited 2021 Jan 18]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0223116-110613.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wu M. The effects of anti-inflammatory marine compound on dermatology disorders. [Thesis]. NSYSU; 2016. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0223116-110613

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Pretoria

16. [No author]. An evaluation of the anti-inflammatory properties of a brown coal derived potassium humate .

Degree: 2008, University of Pretoria

URL: http://upetd.up.ac.za/thesis/available/etd-05122008-125709/

► Humin substances have been used as folk remedies for the last 3000 years. Recent studies have shown that humates possess anti-inflammatory properties, but the mechanism… (more)

▼ Humin substances have been used as folk remedies for the last 3000 years. Recent studies have shown that humates possess anti-inflammatory properties, but the mechanism of how it affects inflammation is still unclear. In this study the anti-inflammatory properties of potassium humate, a water soluble humic acid salt, was investigated on different inflammatory pathways in vitro and in vivo. The effect of potassium humate on human mononuclear lymphocyte proliferation showed that potassium humate stimulated lymphocyte proliferation of resting-, PHA- and PWM-stimulated lymphocytes in vitro from concentrations of 20 to 80 µg/ml, in a dose dependant manner, where a maximum proliferation was observed at 80 µg/ml whereas lymphocyte proliferation decreased at 100 µg/ml. On the contrary potassium humate, at 40 µg/ml, significantly inhibited the supernatant concentrations of the following cytokines; TNF-α, IL-1ß, IL-6 and IL-10 by PHA stimulated lymphocytes. The effect of potassium humate on the alternative as well as the classical complement pathway was investigated in vitro using the haemolytic complement assay. Results indicated that potassium humate inhibits both the alternative and classical complement pathways without affecting the red blood cell membrane stability. Different inflammatory mechanisms were investigated in vivo, using the carrageenan-induced paw oedema model and the delayed type hypersensitivity reaction model. The carrageenan-induced paw oedema model was used to determine the effect of potassium humate on acute inflammation in the hind paw. Carrageenan was injected into the right hind footpad of a rat which caused an increase in paw volume due to oedema, which was measured with a plethysmometer. Potassium humate significantly inhibited the oedema at a dose of 60 mg/kg bodyweight and compared favourably with indomethacin at 10 mg/kg bodyweight. The effect of potassium humate on the delayed type hypersensitivity reaction model was also investigated whereby rats were sensitised with sheep erythrocytes. Potassium humate was administered daily by oral gavage at a dose of 60 mg/kg bodyweight. After 7 days, rats were challenged by injecting sheep erythrocytes into the right hind footpad. The degree of inflammation was determined by measuring the increase of paw volume with a plethysmometer. It was found that potassium humate did not have an anti-inflammatory effect on the delayed type hypersensitivity reaction as opposed to the inhibition caused by dexamethasone at a dose of 30 mg/kg bodyweight. This study showed that potassium humate selectively inhibited the inflammatory pathway of the carrageenan-induced paw oedema as opposed to the delayed type hypersensitivity. The mechanism of the anti-inflammatory property of potassium humate might possibly be due to the inhibition of the complement cascade. This study clearly shows that potassium humate possesses anti-inflammatory properties that can be utilised in the future as a potential treatment for inflammatory disorders associated with the activation of complement.… Advisors/Committee Members: Medlen, C.E (advisor).

Subjects/Keywords: Humate; Anti-inflammatory properties; Inflammation; UCTD

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❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

author], [. (2008). An evaluation of the anti-inflammatory properties of a brown coal derived potassium humate . (Masters Thesis). University of Pretoria. Retrieved from http://upetd.up.ac.za/thesis/available/etd-05122008-125709/

Chicago Manual of Style (16^th Edition):

author], [No. “An evaluation of the anti-inflammatory properties of a brown coal derived potassium humate .” 2008. Masters Thesis, University of Pretoria. Accessed January 18, 2021. http://upetd.up.ac.za/thesis/available/etd-05122008-125709/.

MLA Handbook (7^th Edition):

author], [No. “An evaluation of the anti-inflammatory properties of a brown coal derived potassium humate .” 2008. Web. 18 Jan 2021.

Vancouver:

author] [. An evaluation of the anti-inflammatory properties of a brown coal derived potassium humate . [Internet] [Masters thesis]. University of Pretoria; 2008. [cited 2021 Jan 18]. Available from: http://upetd.up.ac.za/thesis/available/etd-05122008-125709/.

Council of Science Editors:

author] [. An evaluation of the anti-inflammatory properties of a brown coal derived potassium humate . [Masters Thesis]. University of Pretoria; 2008. Available from: http://upetd.up.ac.za/thesis/available/etd-05122008-125709/

Technical University of Lisbon

17. Garrido, Madalena Frias do Vale. Avaliação in vivo do potencial de redução de colesterol, da capacidade antioxidante e anti-inflamatória de farelo de arroz.

Degree: 2015, Technical University of Lisbon

URL: https://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/10956

►

Mestrado em Engenharia Alimentar - Instituto Superior de Agronomia

The present work aims to assess the impact of rice bran ingestion, one of the by-products… (more)

Subjects/Keywords: rice bran; toxicity; cholesterol; antioxidant; anti-inflammatory

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Garrido, M. F. d. V. (2015). Avaliação in vivo do potencial de redução de colesterol, da capacidade antioxidante e anti-inflamatória de farelo de arroz. (Thesis). Technical University of Lisbon. Retrieved from https://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/10956

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Garrido, Madalena Frias do Vale. “Avaliação in vivo do potencial de redução de colesterol, da capacidade antioxidante e anti-inflamatória de farelo de arroz.” 2015. Thesis, Technical University of Lisbon. Accessed January 18, 2021. https://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/10956.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Garrido, Madalena Frias do Vale. “Avaliação in vivo do potencial de redução de colesterol, da capacidade antioxidante e anti-inflamatória de farelo de arroz.” 2015. Web. 18 Jan 2021.

Vancouver:

Garrido MFdV. Avaliação in vivo do potencial de redução de colesterol, da capacidade antioxidante e anti-inflamatória de farelo de arroz. [Internet] [Thesis]. Technical University of Lisbon; 2015. [cited 2021 Jan 18]. Available from: https://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/10956.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Garrido MFdV. Avaliação in vivo do potencial de redução de colesterol, da capacidade antioxidante e anti-inflamatória de farelo de arroz. [Thesis]. Technical University of Lisbon; 2015. Available from: https://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/10956

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Pretoria

18. Naude, P.J.W. (Petrus Johan Wichardt). An evaluation of the anti-inflammatory properties of a brown coal derived potassium humate.

Degree: Pharmacology, 2008, University of Pretoria

URL: http://hdl.handle.net/2263/24574

► Humin substances have been used as folk remedies for the last 3000 years. Recent studies have shown that humates possess anti-inflammatory properties, but the mechanism… (more)

▼ Humin substances have been used as folk remedies for the last 3000 years. Recent studies have shown that humates possess anti-inflammatory properties, but the mechanism of how it affects inflammation is still unclear. In this study the anti-inflammatory properties of potassium humate, a water soluble humic acid salt, was investigated on different inflammatory pathways in vitro and in vivo. The effect of potassium humate on human mononuclear lymphocyte proliferation showed that potassium humate stimulated lymphocyte proliferation of resting-, PHA- and PWM-stimulated lymphocytes in vitro from concentrations of 20 to 80 µg/ml, in a dose dependant manner, where a maximum proliferation was observed at 80 µg/ml whereas lymphocyte proliferation decreased at 100 µg/ml. On the contrary potassium humate, at 40 µg/ml, significantly inhibited the supernatant concentrations of the following cytokines; TNF-α, IL-1ß, IL-6 and IL-10 by PHA stimulated lymphocytes. The effect of potassium humate on the alternative as well as the classical complement pathway was investigated in vitro using the haemolytic complement assay. Results indicated that potassium humate inhibits both the alternative and classical complement pathways without affecting the red blood cell membrane stability. Different inflammatory mechanisms were investigated in vivo, using the carrageenan-induced paw oedema model and the delayed type hypersensitivity reaction model. The carrageenan-induced paw oedema model was used to determine the effect of potassium humate on acute inflammation in the hind paw. Carrageenan was injected into the right hind footpad of a rat which caused an increase in paw volume due to oedema, which was measured with a plethysmometer. Potassium humate significantly inhibited the oedema at a dose of 60 mg/kg bodyweight and compared favourably with indomethacin at 10 mg/kg bodyweight. The effect of potassium humate on the delayed type hypersensitivity reaction model was also investigated whereby rats were sensitised with sheep erythrocytes. Potassium humate was administered daily by oral gavage at a dose of 60 mg/kg bodyweight. After 7 days, rats were challenged by injecting sheep erythrocytes into the right hind footpad. The degree of inflammation was determined by measuring the increase of paw volume with a plethysmometer. It was found that potassium humate did not have an anti-inflammatory effect on the delayed type hypersensitivity reaction as opposed to the inhibition caused by dexamethasone at a dose of 30 mg/kg bodyweight. This study showed that potassium humate selectively inhibited the inflammatory pathway of the carrageenan-induced paw oedema as opposed to the delayed type hypersensitivity. The mechanism of the anti-inflammatory property of potassium humate might possibly be due to the inhibition of the complement cascade. This study clearly shows that potassium humate possesses anti-inflammatory properties that can be utilised in the future as a potential treatment for inflammatory disorders associated with the activation of complement.… Advisors/Committee Members: Medlen, C.E. (advisor).

Subjects/Keywords: Humate; Anti-inflammatory properties; Inflammation; UCTD

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❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Naude, P. J. W. (. J. (2008). An evaluation of the anti-inflammatory properties of a brown coal derived potassium humate. (Masters Thesis). University of Pretoria. Retrieved from http://hdl.handle.net/2263/24574

Chicago Manual of Style (16^th Edition):

Naude, P J W (Petrus Johan. “An evaluation of the anti-inflammatory properties of a brown coal derived potassium humate.” 2008. Masters Thesis, University of Pretoria. Accessed January 18, 2021. http://hdl.handle.net/2263/24574.

MLA Handbook (7^th Edition):

Naude, P J W (Petrus Johan. “An evaluation of the anti-inflammatory properties of a brown coal derived potassium humate.” 2008. Web. 18 Jan 2021.

Vancouver:

Naude PJW(J. An evaluation of the anti-inflammatory properties of a brown coal derived potassium humate. [Internet] [Masters thesis]. University of Pretoria; 2008. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/2263/24574.

Council of Science Editors:

Naude PJW(J. An evaluation of the anti-inflammatory properties of a brown coal derived potassium humate. [Masters Thesis]. University of Pretoria; 2008. Available from: http://hdl.handle.net/2263/24574

Oregon State University

19. Sartnurak, Soisurin. Evaluation of solid dispersed particles for formulation of oral ibuprofen tablets.

Degree: PhD, Pharmacy, 1985, Oregon State University

URL: http://hdl.handle.net/1957/40873

► Dissolution profiles of two commercial products (Motrine and Rufen®) were analyzed and compared at 8 pH levels, ranging from pH 2.0 to pH 8.0. It… (more)

▼ Dissolution profiles of two commercial products (Motrine and Rufen®) were analyzed and compared at 8 pH levels, ranging from pH 2.0 to pH 8.0. It was demonstrated, as expected, that the rate and extent of ibuprofen dissolution dissolution was pH dependent. In vitro dissolution characteristics of the ibuprofen solid dispersion formulations prepared by freeze-drying method with various proportions of excipients (theobroma oil, lecithin and PEG 20,000) were investigated at 3 pH levels - pH 2.0, 5.4, and 7.2. As the amount of theobroma oil increased from zero to 31%, the dissolution rate and the percent ibuprofen dissolved was decreased. Freeze-dried systems with a combination of lecithin and PEG 20,000 showed a slower dissolution rate and less amount of drug dissolved than the formulation with only PEG 20,000. The optimal ratio of drug to PEG 20,000 was 1:1. Solid dispersions of ibuprofen prepared by the freezedrying method provided the highest dissolution rate and percentage of drug dissolved when compared with the direct melting method, the solvent method or the physical-mixing method. Dissolution characteristics of the ibuprofen freeze-dried formulation (ratio of drug to PEG 20,000 1:1) were unaffected after storage in 98% relative humidity, but commercial formulation dissolution was drastically reduced. Relative bioavailability of ibuprofen solid dispersed tablets were studied in rabbits after a single oral administration of 50 mg ibuprofen preparations. The freeze-dried solid dispersion formulation with ratio of drug to PEG 1:1 exhibited the greatest relative extent of absorption (129.50 +̲ 27.99% over control). Preparations with PEG 20,000 enhanced the extent of absorption when compared to the formulation of ibuprofen drug powder. There appeared no advantage in formulating ibuprofen in PEG by freeze-drying over the direct melting method. A slower rate of absorption of ibuprofen was obtained when the amount of theobroma oil was increased in the formulation. Advisors/Committee Members: Christensen, John M. (advisor).

Subjects/Keywords: Anti-inflammatory agents

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sartnurak, S. (1985). Evaluation of solid dispersed particles for formulation of oral ibuprofen tablets. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/40873

Chicago Manual of Style (16^th Edition):

Sartnurak, Soisurin. “Evaluation of solid dispersed particles for formulation of oral ibuprofen tablets.” 1985. Doctoral Dissertation, Oregon State University. Accessed January 18, 2021. http://hdl.handle.net/1957/40873.

MLA Handbook (7^th Edition):

Sartnurak, Soisurin. “Evaluation of solid dispersed particles for formulation of oral ibuprofen tablets.” 1985. Web. 18 Jan 2021.

Vancouver:

Sartnurak S. Evaluation of solid dispersed particles for formulation of oral ibuprofen tablets. [Internet] [Doctoral dissertation]. Oregon State University; 1985. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/1957/40873.

Council of Science Editors:

Sartnurak S. Evaluation of solid dispersed particles for formulation of oral ibuprofen tablets. [Doctoral Dissertation]. Oregon State University; 1985. Available from: http://hdl.handle.net/1957/40873

Rhodes University

20. Tettey-Amlalo, Ralph Nii Okai. Application of dermal microdialysis and tape stripping methods to determine the bioavailability and/or bioequivalence of topical ketoprofen formulations.

Degree: PhD, Faculty of Pharmacy, Pharmacy, 2008, Rhodes University

URL: http://hdl.handle.net/10962/d1003274

► The widespread acceptance of topical formulations intended for local and/or regional activity has prompted renewed interest in developing a model to determine the bioavailability of… (more)

▼ The widespread acceptance of topical formulations intended for local and/or regional activity has prompted renewed interest in developing a model to determine the bioavailability of drugs in order to establish bioequivalence as a means of evaluating formulation performance of multisource products and also for use during formulation development. Current in vivo techniques such as blister suction and skin biopsy amongst others used to determine the bioavailability and/or bioequivalence of topical formulations are either too invasive to generate appropriate concentration-time profiles or require large numbers of study subjects thereby making the study expensive and time-consuming. Moreover, there are currently no sampling techniques that can demonstrate dermal bioavailability and/or bioequivalence of topical formulations intended for local and/or regional activity. Dermal microdialysis is a relatively new application of microdialysis that permits continuous monitoring of endogenous and/or exogenous solutes in the interstitial fluid. The technique is involves the implantation of semi-permeable membranes which are perfused with an isotonic medium at extremely slow flow rates and collection of microlitre sample volumes containing diffused drugs. Tape stripping, a relatively older technique, has been extensively used in comparative bioavailability studies of various topical formulations. However, due to shortcomings arising from reproducibility and inter-subject variation amongst others, the published FDA guidance outlining the initial protocol was subsequently withdrawn. The incorporation of transepidermal water loss with tape stripping has garnered renewed interest and has been used for the determination of drug bioavailability from a number of topical formulations. Hence the primary objective of this research is to develop and evaluate microdialysis sampling and tape stripping techniques, including the incorporation of the determination of transepidermal water loss, to assess the dermal bioavailability of ketoprofen from topical gel formulations and to develop models for bioequivalence assessment. A rapid UPLC-MS/MS method with requisite sensitivity for the analysis of samples generated from dermal microdialysis was developed and validated which accommodated the microlitre sample volumes collected. An HPLC-UV method was developed and validated for the analysis of samples generated from the in vitro microdialysis and in vivo tape stripping studies. The work presented herein contributes to a growing body of scientific knowledge seeking to develop a model for the determination of bioequivalence of pharmaceutically equivalent topical formulations intended for local and/or regional activity in human subjects.

Subjects/Keywords: Drugs – Therapeutic equivalency; Transdermal medication; High performance liquid chromatography; Nonsteroidal anti-inflammatory agents – Bioavailability; Nonsteroidal anti-inflammatory agents – Effectiveness; Nonsteroidal anti-inflammatory agents – Testing; Nonsteroidal anti-inflammatory agents – Side effects

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tettey-Amlalo, R. N. O. (2008). Application of dermal microdialysis and tape stripping methods to determine the bioavailability and/or bioequivalence of topical ketoprofen formulations. (Doctoral Dissertation). Rhodes University. Retrieved from http://hdl.handle.net/10962/d1003274

Chicago Manual of Style (16^th Edition):

Tettey-Amlalo, Ralph Nii Okai. “Application of dermal microdialysis and tape stripping methods to determine the bioavailability and/or bioequivalence of topical ketoprofen formulations.” 2008. Doctoral Dissertation, Rhodes University. Accessed January 18, 2021. http://hdl.handle.net/10962/d1003274.

MLA Handbook (7^th Edition):

Tettey-Amlalo, Ralph Nii Okai. “Application of dermal microdialysis and tape stripping methods to determine the bioavailability and/or bioequivalence of topical ketoprofen formulations.” 2008. Web. 18 Jan 2021.

Vancouver:

Tettey-Amlalo RNO. Application of dermal microdialysis and tape stripping methods to determine the bioavailability and/or bioequivalence of topical ketoprofen formulations. [Internet] [Doctoral dissertation]. Rhodes University; 2008. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10962/d1003274.

Council of Science Editors:

Tettey-Amlalo RNO. Application of dermal microdialysis and tape stripping methods to determine the bioavailability and/or bioequivalence of topical ketoprofen formulations. [Doctoral Dissertation]. Rhodes University; 2008. Available from: http://hdl.handle.net/10962/d1003274

21. Tandel, Falguni B. Analytical method development and pharmacokinetic study of some new anti inflammatory agents.

Degree: 2015, Suamandeep Vidyapeeth University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/35309

newline Advisors/Committee Members: Pandya, S S.

Subjects/Keywords: ANTI INFLAMMATORY; PHARMACOKINETIC

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tandel, F. B. (2015). Analytical method development and pharmacokinetic study of some new anti inflammatory agents. (Thesis). Suamandeep Vidyapeeth University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/35309

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tandel, Falguni B. “Analytical method development and pharmacokinetic study of some new anti inflammatory agents.” 2015. Thesis, Suamandeep Vidyapeeth University. Accessed January 18, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/35309.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tandel, Falguni B. “Analytical method development and pharmacokinetic study of some new anti inflammatory agents.” 2015. Web. 18 Jan 2021.

Vancouver:

Tandel FB. Analytical method development and pharmacokinetic study of some new anti inflammatory agents. [Internet] [Thesis]. Suamandeep Vidyapeeth University; 2015. [cited 2021 Jan 18]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/35309.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tandel FB. Analytical method development and pharmacokinetic study of some new anti inflammatory agents. [Thesis]. Suamandeep Vidyapeeth University; 2015. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/35309

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

22. Bhati, Sudhir kumar. A stduy on synthesis of newer heterocyclics and their anti inflammatory activities;.

Degree: Chemistry, 2007, Chaudhary Charan Singh University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/24918

None newline

Summary p.i-ix, Bibliography p. 200-223

Advisors/Committee Members: Ashok Kumar.

Subjects/Keywords: Heterocyclics; Anti Inflammatory

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bhati, S. k. (2007). A stduy on synthesis of newer heterocyclics and their anti inflammatory activities;. (Thesis). Chaudhary Charan Singh University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/24918

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bhati, Sudhir kumar. “A stduy on synthesis of newer heterocyclics and their anti inflammatory activities;.” 2007. Thesis, Chaudhary Charan Singh University. Accessed January 18, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/24918.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bhati, Sudhir kumar. “A stduy on synthesis of newer heterocyclics and their anti inflammatory activities;.” 2007. Web. 18 Jan 2021.

Vancouver:

Bhati Sk. A stduy on synthesis of newer heterocyclics and their anti inflammatory activities;. [Internet] [Thesis]. Chaudhary Charan Singh University; 2007. [cited 2021 Jan 18]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/24918.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bhati Sk. A stduy on synthesis of newer heterocyclics and their anti inflammatory activities;. [Thesis]. Chaudhary Charan Singh University; 2007. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/24918

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

North Carolina State University

23. Marshall, John Fraser. The Effect of Novel Anti-inflammatory Drugs on the Cyclooxygenase Enzymes and Recovery of Mucosal Barrier Function.

Degree: PhD, Physiology, 2010, North Carolina State University

URL: http://www.lib.ncsu.edu/resolver/1840.16/6239

► The non-steroidal anti-inflammatory drugs (NSAIDs) are a large group of drugs that are commonly used for the treatment of pain and inflammation in the veterinary… (more)

▼ The non-steroidal anti-inflammatory drugs (NSAIDs) are a large group of drugs that are commonly used for the treatment of pain and inflammation in the veterinary species. The NSAIDs inhibit the action of the cyclooxygenase (COX) enzymes, COX-1 and COX-2, to reduce the production of prostaglandins. However, their use is associated with adverse effects, particularly in the gastrointestinal tract which may be related to the inhibition of COX-1. To reduce the incidence of these effects, NSAIDs have been designed to selectively inhibit COX-2 while allowing physiologic prostaglandin production by COX-1. The first experiments of this thesis aimed to determine the effect of three NSAIDs in the horse. Flunixin meglumine is commonly used to treat pain and endotoxemia associated with colic in the horse. Deracoxib and firocoxib have been shown to be COX-2 selective in the dog. This study used in vitro whole blood assays to determine the effect of flunixin meglumine, deracoxib, and firocoxib on the COX enzymes. Using this model, flunixin meglumine was shown to non-selectively inhibit COX-1 and COX-2 in the horse. In contrast, deracoxib and firocoxib selectively inhibited COX-2 in the horse. Using an in vitro equine whole blood assay, the next project determined that the novel NSAID robenacoxib is COX-2 selective in the horse. The effect of robenacoxib and flunixin meglumine on the recovery of ischemic-injured equine jejunum was then compared using an equine ex vivo model. While flunixin meglumine significantly inhibited the production of prostaglandin E2 (PGE2) and the recovery of barrier function, robenacoxib allowed barrier function to recovery and production of PGE2. The mechanism of action of the novel anti-inflammatory compound AHI-805 is currently unknown. Using an in vitro equine whole blood model, the effect of AHI-805 on COX-1 and COX-2 was determined. While AHI-805 did not inhibit COX-1, it did significantly inhibit the action of COX-2. The effect of AHI-805 on the recovery of mucosal barrier function in ischemic injured equine jejunum was determined using an equine ex vivo model. Treatment of ischemic injured equine jejunum with AHI-805 significantly inhibited the recovery of mucosal barrier function. Furthermore, in this ex vivo model AHI-805 significantly inhibited the action of both COX-1 and COX-2. Advisors/Committee Members: Adam Moeser, Committee Member (advisor), Jody Gookin, Committee Member (advisor), Anthony Blikslager, Committee Chair (advisor), Samuel Jones, Committee Member (advisor).

Subjects/Keywords: Non-steroidal anti-inflammatory drug; horse; gastroenterology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Marshall, J. F. (2010). The Effect of Novel Anti-inflammatory Drugs on the Cyclooxygenase Enzymes and Recovery of Mucosal Barrier Function. (Doctoral Dissertation). North Carolina State University. Retrieved from http://www.lib.ncsu.edu/resolver/1840.16/6239

Chicago Manual of Style (16^th Edition):

Marshall, John Fraser. “The Effect of Novel Anti-inflammatory Drugs on the Cyclooxygenase Enzymes and Recovery of Mucosal Barrier Function.” 2010. Doctoral Dissertation, North Carolina State University. Accessed January 18, 2021. http://www.lib.ncsu.edu/resolver/1840.16/6239.

MLA Handbook (7^th Edition):

Marshall, John Fraser. “The Effect of Novel Anti-inflammatory Drugs on the Cyclooxygenase Enzymes and Recovery of Mucosal Barrier Function.” 2010. Web. 18 Jan 2021.

Vancouver:

Marshall JF. The Effect of Novel Anti-inflammatory Drugs on the Cyclooxygenase Enzymes and Recovery of Mucosal Barrier Function. [Internet] [Doctoral dissertation]. North Carolina State University; 2010. [cited 2021 Jan 18]. Available from: http://www.lib.ncsu.edu/resolver/1840.16/6239.

Council of Science Editors:

Marshall JF. The Effect of Novel Anti-inflammatory Drugs on the Cyclooxygenase Enzymes and Recovery of Mucosal Barrier Function. [Doctoral Dissertation]. North Carolina State University; 2010. Available from: http://www.lib.ncsu.edu/resolver/1840.16/6239

Addis Ababa University

24. ABRAHAM, SILESHI. Anti inflammatory and bacterial effect of Arthrospira .

Degree: 2012, Addis Ababa University

URL: http://etd.aau.edu.et/dspace/handle/123456789/355

► Arthrospira platensis (spirulina) is multicellular filamentous blue green alga that is abundantly found in lakes of high salinity in Ethiopia. Several studies have shown that… (more)

▼ Arthrospira platensis (spirulina) is multicellular filamentous blue green alga that is abundantly found in lakes of high salinity in Ethiopia. Several studies have shown that it has importance in human health and nutrition. The health benefits of spirulina relies mainly on tits anti-inflammatory, anti- oxidant and antimicrobial properties. In the current study spirulina was studied for its anti-inflammatory and antimicrobial effects using change in size and number of S. mansoni induced granuloma in infected mice and inhibitions of known human bacterial pathogens (S. typhi, S. dysenteriae, E. coli, S. aureus, S. epidermidis, C. freundii, and P. aeruginosa) as parameters. S. mansoni is a parasitic helmintic infection with high public health importance next to malaria, HIV-AIDS and TB especially in sub Saharan countries. Chronic inflammatory response in response to S. mansoni egg trapped in liver tissue is the main pathology responsible for the morbidity and mortality associated with the disease. Methodologies used in the study involve S. mansoni infection of Swiss albino mice, treatment of experimental animals with spirulina at two doses 100 and 400 mg/kg through oral, rectal, and oral/rectal. Animal dissection and histological staining of the liver to measure granuloma diameter, and finally antibiotic sensitivity test using disk diffusion method was done. Independent T. test comparison of the measurements form the anti-inflammatory test showed that the size of granuloma around an egg from spirulina treated compared to controls was significantly reduced. In association with this, comparison between different treated groups showed that treatment through oral route at a dose of 400 mg/ kg scores the highest percentage reduction both in granuloma size (59.53%) and granuloma number (72%). Result from the antimicrobial study showed that all test organisms except S. typhi were susceptible for the water suspension and extracts of spirulina unlike that of the Methanol extract. The possible explanations are discussed. In conclusion and recommendation the anti-inflammatory and antimicrobial effect of spirulina are summarized and future direction of research indicated. In association with this spirulina’s role in child health care and fight against child malnutrition and morbidity due to infection is underscored. Advisors/Committee Members: MEKURIA LAKEW (Assoc.Prof) (advisor).

Subjects/Keywords: Spirulina; S. mansoni; Granuloma; Anti-inflammatory; Antimicrobia

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APA (6^th Edition):

ABRAHAM, S. (2012). Anti inflammatory and bacterial effect of Arthrospira . (Thesis). Addis Ababa University. Retrieved from http://etd.aau.edu.et/dspace/handle/123456789/355

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

ABRAHAM, SILESHI. “Anti inflammatory and bacterial effect of Arthrospira .” 2012. Thesis, Addis Ababa University. Accessed January 18, 2021. http://etd.aau.edu.et/dspace/handle/123456789/355.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

ABRAHAM, SILESHI. “Anti inflammatory and bacterial effect of Arthrospira .” 2012. Web. 18 Jan 2021.

Vancouver:

ABRAHAM S. Anti inflammatory and bacterial effect of Arthrospira . [Internet] [Thesis]. Addis Ababa University; 2012. [cited 2021 Jan 18]. Available from: http://etd.aau.edu.et/dspace/handle/123456789/355.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

ABRAHAM S. Anti inflammatory and bacterial effect of Arthrospira . [Thesis]. Addis Ababa University; 2012. Available from: http://etd.aau.edu.et/dspace/handle/123456789/355

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Addis Ababa University

25. Temesgen, Sidamo. Wound Healing Activity of Kalanchoae Petitiana Leaf Extracts in Mice .

Degree: 2010, Addis Ababa University

URL: http://etd.aau.edu.et/dspace/handle/123456789/5543

► Kalanchoae petitiana (Crassulaceae) is known for its use in traditional medicine in different areas of Ethiopia. The plant is traditionally claimed to be used in… (more)

▼ Kalanchoae petitiana (Crassulaceae) is known for its use in traditional medicine in different areas of Ethiopia. The plant is traditionally claimed to be used in the treatment of tapeworms, trachoma, syphilis, different swellings, epilepsy, rabies, constipation and hemorrhoid etc. This work deals with the wound healing potential of 80% methanolic and chloroform extracts of the plant leaves. To this end, the study was conducted by using incision, excision, and dead-space wound models in mice. For excision and incision wounds ointment and gel preparations of the methanolic and chloroform extracts, respectively, were used whereas oral suspension of the methanolic extract was employed in dead space wound. The parameters studied for the evaluation of the wound healing activity of the plant include rate of wound contraction and period of complete epithelialization in excision wound, skin breaking strength of incision wound, and granulation tissue wet and dry weights and the hydroxyproline contents in dead space wound. The 80% methanolic extract of the plant was found to possess significant wound healing(P<0.01) activity, as it was evidenced by decrease in the period of epithelialization, increase in the rate of wound contraction, higher skin breaking strength, increase in granulation tissue wet and dry weights and increased hydroxyproline content in the three experimental models as compared to controls. However, the wound healing effect of the chloroform extract was found to be weaker in that it showed significant healing (P<0.05) only in incision wound in the larger dose (10% gel). The results of the 5% and 10% chloroform extract gel in excision wounds were not significantly different from the control values. Also tests for anti-inflammatory and antioxidant activities were carried out with the methanolic extract of the plant and the results were found to be positive. The results of this study support the traditional claim for the wound healing activity of the extracts of Kalanchoae petitiana. Other activities such as anti-inflammatory and antioxidant activities seem to corroborate the wound healing activity of the plant. Advisors/Committee Members: Ephrem Engidawork (PhD) (advisor).

Subjects/Keywords: Wound healing; Kalanchoae petitiana; Anti-inflammatory activity

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APA (6^th Edition):

Temesgen, S. (2010). Wound Healing Activity of Kalanchoae Petitiana Leaf Extracts in Mice . (Thesis). Addis Ababa University. Retrieved from http://etd.aau.edu.et/dspace/handle/123456789/5543

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Temesgen, Sidamo. “Wound Healing Activity of Kalanchoae Petitiana Leaf Extracts in Mice .” 2010. Thesis, Addis Ababa University. Accessed January 18, 2021. http://etd.aau.edu.et/dspace/handle/123456789/5543.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Temesgen, Sidamo. “Wound Healing Activity of Kalanchoae Petitiana Leaf Extracts in Mice .” 2010. Web. 18 Jan 2021.

Vancouver:

Temesgen S. Wound Healing Activity of Kalanchoae Petitiana Leaf Extracts in Mice . [Internet] [Thesis]. Addis Ababa University; 2010. [cited 2021 Jan 18]. Available from: http://etd.aau.edu.et/dspace/handle/123456789/5543.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Temesgen S. Wound Healing Activity of Kalanchoae Petitiana Leaf Extracts in Mice . [Thesis]. Addis Ababa University; 2010. Available from: http://etd.aau.edu.et/dspace/handle/123456789/5543

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Addis Ababa University

26. Helen, Geremew. Evaluation of Analgesic and Anti -inflammatory activity of Moringa stenopetala Bak.(Moringaceae) in mice.

Degree: 2014, Addis Ababa University

URL: http://etd.aau.edu.et/dspace/handle/123456789/6081

► Moringa stenopetala Bak F.is commonly used in folk medicine as a single drug remedy to treat various aliments like; hypertension, headache, stomach disorders, asthma, diabetes… (more)

Subjects/Keywords: M. stenopetala; analgesic activity; anti- inflammatory activity

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APA (6^th Edition):

Helen, G. (2014). Evaluation of Analgesic and Anti -inflammatory activity of Moringa stenopetala Bak.(Moringaceae) in mice. (Thesis). Addis Ababa University. Retrieved from http://etd.aau.edu.et/dspace/handle/123456789/6081

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Helen, Geremew. “Evaluation of Analgesic and Anti -inflammatory activity of Moringa stenopetala Bak.(Moringaceae) in mice. ” 2014. Thesis, Addis Ababa University. Accessed January 18, 2021. http://etd.aau.edu.et/dspace/handle/123456789/6081.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Helen, Geremew. “Evaluation of Analgesic and Anti -inflammatory activity of Moringa stenopetala Bak.(Moringaceae) in mice. ” 2014. Web. 18 Jan 2021.

Vancouver:

Helen G. Evaluation of Analgesic and Anti -inflammatory activity of Moringa stenopetala Bak.(Moringaceae) in mice. [Internet] [Thesis]. Addis Ababa University; 2014. [cited 2021 Jan 18]. Available from: http://etd.aau.edu.et/dspace/handle/123456789/6081.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Helen G. Evaluation of Analgesic and Anti -inflammatory activity of Moringa stenopetala Bak.(Moringaceae) in mice. [Thesis]. Addis Ababa University; 2014. Available from: http://etd.aau.edu.et/dspace/handle/123456789/6081

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Addis Ababa University

27. Tigist, Leyikun. Evaluation of the analgesic and anti-inflammatory activities of 80% methanol leaf extract of Stephania abyssinica (Quart.-Dill. & A. Rich.) Walp. (Menispermaceae) in mice .

Degree: 2015, Addis Ababa University

URL: http://etd.aau.edu.et/dspace/handle/123456789/7559

► Stephania abyssinica is used in Ethiopian traditional medicine for the treatment of stomachache, headache and inflammation. The present study evaluated the 80% methanol leaf extract… (more)

Subjects/Keywords: Analgesic activity; Anti- inflammatory activity; Stephania abyssinica

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APA (6^th Edition):

Tigist, L. (2015). Evaluation of the analgesic and anti-inflammatory activities of 80% methanol leaf extract of Stephania abyssinica (Quart.-Dill. & A. Rich.) Walp. (Menispermaceae) in mice . (Thesis). Addis Ababa University. Retrieved from http://etd.aau.edu.et/dspace/handle/123456789/7559

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tigist, Leyikun. “Evaluation of the analgesic and anti-inflammatory activities of 80% methanol leaf extract of Stephania abyssinica (Quart.-Dill. & A. Rich.) Walp. (Menispermaceae) in mice .” 2015. Thesis, Addis Ababa University. Accessed January 18, 2021. http://etd.aau.edu.et/dspace/handle/123456789/7559.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tigist, Leyikun. “Evaluation of the analgesic and anti-inflammatory activities of 80% methanol leaf extract of Stephania abyssinica (Quart.-Dill. & A. Rich.) Walp. (Menispermaceae) in mice .” 2015. Web. 18 Jan 2021.

Vancouver:

Tigist L. Evaluation of the analgesic and anti-inflammatory activities of 80% methanol leaf extract of Stephania abyssinica (Quart.-Dill. & A. Rich.) Walp. (Menispermaceae) in mice . [Internet] [Thesis]. Addis Ababa University; 2015. [cited 2021 Jan 18]. Available from: http://etd.aau.edu.et/dspace/handle/123456789/7559.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tigist L. Evaluation of the analgesic and anti-inflammatory activities of 80% methanol leaf extract of Stephania abyssinica (Quart.-Dill. & A. Rich.) Walp. (Menispermaceae) in mice . [Thesis]. Addis Ababa University; 2015. Available from: http://etd.aau.edu.et/dspace/handle/123456789/7559

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Nairobi

28. Odongo, Elizabeth A. An Ethnobotanical, Antioxidant And Anti-Inflammatory Study Of Medicinal Plants Used In Kakamega County, Western Kenya .

Degree: 2016, University of Nairobi

URL: http://hdl.handle.net/11295/100283

► Background For years, medicinal plants have been used worldwide for the treatment of various diseases. Generally, they are considered safer, easily available and more cost… (more)

▼ Background For years, medicinal plants have been used worldwide for the treatment of various diseases. Generally, they are considered safer, easily available and more cost effective compared to conventional medicine. To date, medicinal plants still remain a promising source of natural antioxidant and anti-inflammatory agents to address the increasing burden of diseases related to oxidative damage and inflammation. Objective The aim of the present work was to screen medicinal plants commonly used in Kakamega county, western Kenya for their antioxidant and anti-inflammatory activity. Methodology An ethnobotanical survey was undertaken to establish medicinal plants used to treat various ailments in Kakamega County. Direct interviews were carried out using structured questionnaires. Plant specimens were collected, identified and voucher specimens deposited at the herbarium at the School of Biological Sciences, University of Nairobi. The plants were air dried at room temperature and ground into powder using a hammer mill(Muharatta mechanical grinder). Extraction was carried out using methanol. Antioxidant activity was then screened using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) assay while carrageenan induced rat paw edema assay was used to screen for anti-inflammatory activity of the selected medicinal plants. Results A total of 94 plant species from 41 families were reported to be used as medicinal plants in Kakamega County by 26 respondents. Most of the plants reported were from the Asteraceae (13.8 %) and Fabaceae (11.7 %) families. Majority of the plants were prepared by boiling or as poultices.24 plant species were for the first time reported to be used in the area and had not been xiv previously reported in similar studies within and around the area. Common ailments treated were malaria, stomach aches, skin diseases, joint aches, and sexually transmitted infections. Some of the herbal remedies were used alongside conventional medicines for the treatment of the various chronic ailments such as HIV/AIDS. Seven plants were selected for screening of antioxidant activity based on their ethno medicinal use and an extensive literature review. The methanolic leaf extracts of Rhus vulgaris and Phyllanthus fischeri displayed relatively high antioxidant activity with IC50 values of 163.63 μg/ml and 182.15μg/ml, respectively. The methanolic leaf extracts of Senna didymobotrya, Justicia betonica,Warburgia ugandensis, Kalanchoe densiflora and Solanum dasyphylum had weak antioxidant activity with IC50 ranging from 1029 μg/ml to 4051μg/ml . The methanolic leaf extracts of Rhus vulgaris and Phyllanthus fischeri were screened for their anti-inflammatory activity using indomethacin as a standard. For indomethacin and Rhus vulgaris extract, there was a statistically significant difference in the paw size when compared to the vehicle at all the different time points while Phyllanthus fischeri displayed mild activity. Conclusion and recommendations Medicinal plants are widely used in Kakamega County…

Subjects/Keywords: An Ethnobotanical; Antioxidant And Anti-Inflammatory

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APA (6^th Edition):

Odongo, E. A. (2016). An Ethnobotanical, Antioxidant And Anti-Inflammatory Study Of Medicinal Plants Used In Kakamega County, Western Kenya . (Thesis). University of Nairobi. Retrieved from http://hdl.handle.net/11295/100283

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Odongo, Elizabeth A. “An Ethnobotanical, Antioxidant And Anti-Inflammatory Study Of Medicinal Plants Used In Kakamega County, Western Kenya .” 2016. Thesis, University of Nairobi. Accessed January 18, 2021. http://hdl.handle.net/11295/100283.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Odongo, Elizabeth A. “An Ethnobotanical, Antioxidant And Anti-Inflammatory Study Of Medicinal Plants Used In Kakamega County, Western Kenya .” 2016. Web. 18 Jan 2021.

Vancouver:

Odongo EA. An Ethnobotanical, Antioxidant And Anti-Inflammatory Study Of Medicinal Plants Used In Kakamega County, Western Kenya . [Internet] [Thesis]. University of Nairobi; 2016. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/11295/100283.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Odongo EA. An Ethnobotanical, Antioxidant And Anti-Inflammatory Study Of Medicinal Plants Used In Kakamega County, Western Kenya . [Thesis]. University of Nairobi; 2016. Available from: http://hdl.handle.net/11295/100283

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Boston University

29. Andreucci, Amy Jada. Are anti-inflammatory drugs an appropriate option for treating obesity?.

Degree: MA, Pharmacology, 2013, Boston University

URL: http://hdl.handle.net/2144/17121

► Obese people with insulin resistance are at high risk of developing disease-related complications like heart attack and stroke. Recently, a significant amount of data has… (more)

Subjects/Keywords: Metabolic syndrome; MetS; Obesity; Anti-inflammatory drugs

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APA (6^th Edition):

Andreucci, A. J. (2013). Are anti-inflammatory drugs an appropriate option for treating obesity?. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/17121

Chicago Manual of Style (16^th Edition):

Andreucci, Amy Jada. “Are anti-inflammatory drugs an appropriate option for treating obesity?.” 2013. Masters Thesis, Boston University. Accessed January 18, 2021. http://hdl.handle.net/2144/17121.

MLA Handbook (7^th Edition):

Andreucci, Amy Jada. “Are anti-inflammatory drugs an appropriate option for treating obesity?.” 2013. Web. 18 Jan 2021.

Vancouver:

Andreucci AJ. Are anti-inflammatory drugs an appropriate option for treating obesity?. [Internet] [Masters thesis]. Boston University; 2013. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/2144/17121.

Council of Science Editors:

Andreucci AJ. Are anti-inflammatory drugs an appropriate option for treating obesity?. [Masters Thesis]. Boston University; 2013. Available from: http://hdl.handle.net/2144/17121

University of Gothenburg / Göteborgs Universitet

30. Josefsson, Elisabet, 1966-. Neuroendocrine modulation of inflammatory and immune responsiveness.

Degree: 1995, University of Gothenburg / Göteborgs Universitet

URL: http://hdl.handle.net/2077/12096

Subjects/Keywords: Anti-inflammatory agents

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Josefsson, Elisabet, 1. (1995). Neuroendocrine modulation of inflammatory and immune responsiveness. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/12096

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Josefsson, Elisabet, 1966-. “Neuroendocrine modulation of inflammatory and immune responsiveness.” 1995. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed January 18, 2021. http://hdl.handle.net/2077/12096.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Josefsson, Elisabet, 1966-. “Neuroendocrine modulation of inflammatory and immune responsiveness.” 1995. Web. 18 Jan 2021.

Vancouver:

Josefsson, Elisabet 1. Neuroendocrine modulation of inflammatory and immune responsiveness. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 1995. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/2077/12096.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Josefsson, Elisabet 1. Neuroendocrine modulation of inflammatory and immune responsiveness. [Thesis]. University of Gothenburg / Göteborgs Universitet; 1995. Available from: http://hdl.handle.net/2077/12096

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Open Access Theses and Dissertations