subject:(anemia)

1. Flores Hidalgo, Jesús Mijael. Prevalencia de anemia en gestantes del centro de salud La Libertad, San Juan de Lurigancho, Lima, enero - octubre del 2015.

Degree: Médico Cirujano, Medicina Humana, 2017, National University of San Marcos

URL: http://hdl.handle.net/20.500.12672/6142

► Determina la prevalencia de anemia en gestantes, que acuden a su primer control prenatal, del centro de salud La Libertad de Lima. Para ello, estima… (more)

Subjects/Keywords: Anemia en embarazo; Anemia - Diagnóstico

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APA (6^th Edition):

Flores Hidalgo, J. M. (2017). Prevalencia de anemia en gestantes del centro de salud La Libertad, San Juan de Lurigancho, Lima, enero - octubre del 2015. (Thesis). National University of San Marcos. Retrieved from http://hdl.handle.net/20.500.12672/6142

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Flores Hidalgo, Jesús Mijael. “Prevalencia de anemia en gestantes del centro de salud La Libertad, San Juan de Lurigancho, Lima, enero - octubre del 2015.” 2017. Thesis, National University of San Marcos. Accessed April 20, 2021. http://hdl.handle.net/20.500.12672/6142.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Flores Hidalgo, Jesús Mijael. “Prevalencia de anemia en gestantes del centro de salud La Libertad, San Juan de Lurigancho, Lima, enero - octubre del 2015.” 2017. Web. 20 Apr 2021.

Vancouver:

Flores Hidalgo JM. Prevalencia de anemia en gestantes del centro de salud La Libertad, San Juan de Lurigancho, Lima, enero - octubre del 2015. [Internet] [Thesis]. National University of San Marcos; 2017. [cited 2021 Apr 20]. Available from: http://hdl.handle.net/20.500.12672/6142.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Flores Hidalgo JM. Prevalencia de anemia en gestantes del centro de salud La Libertad, San Juan de Lurigancho, Lima, enero - octubre del 2015. [Thesis]. National University of San Marcos; 2017. Available from: http://hdl.handle.net/20.500.12672/6142

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Oregon State University

2. Oldfield, J. E., 1921-. Iron deficiency anemia as a contributory cause of early mortality in swine.

Degree: PhD, Animal Nutrition, 1951, Oregon State University

URL: http://hdl.handle.net/1957/52129

Subjects/Keywords: Anemia

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APA (6^th Edition):

Oldfield, J. E., 1. (1951). Iron deficiency anemia as a contributory cause of early mortality in swine. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/52129

Chicago Manual of Style (16^th Edition):

Oldfield, J. E., 1921-. “Iron deficiency anemia as a contributory cause of early mortality in swine.” 1951. Doctoral Dissertation, Oregon State University. Accessed April 20, 2021. http://hdl.handle.net/1957/52129.

MLA Handbook (7^th Edition):

Oldfield, J. E., 1921-. “Iron deficiency anemia as a contributory cause of early mortality in swine.” 1951. Web. 20 Apr 2021.

Vancouver:

Oldfield, J. E. 1. Iron deficiency anemia as a contributory cause of early mortality in swine. [Internet] [Doctoral dissertation]. Oregon State University; 1951. [cited 2021 Apr 20]. Available from: http://hdl.handle.net/1957/52129.

Council of Science Editors:

Oldfield, J. E. 1. Iron deficiency anemia as a contributory cause of early mortality in swine. [Doctoral Dissertation]. Oregon State University; 1951. Available from: http://hdl.handle.net/1957/52129

3. Peraki, Ioanna. The role of Erf in mouse development.

Degree: 2017, University of Crete (UOC); Πανεπιστήμιο Κρήτης

URL: http://hdl.handle.net/10442/hedi/41243

► Erf is a ubiquitously expressed transcriptional repressor regulated by MAPK via nucleo-cytoplasmic shuttling. In its non-phosphorylated form, Erf is nuclear and active as a repressor,… (more)

▼ Erf is a ubiquitously expressed transcriptional repressor regulated by MAPK via nucleo-cytoplasmic shuttling. In its non-phosphorylated form, Erf is nuclear and active as a repressor, while phosphorylation by Erks in the nucleus, leads to cytoplasmic export and inactivation. In its active nuclear form, Erf blocks cell proliferation and arrests cells at G0/G1 phase in a cell type-specific manner. Moreover, Erk signaling is essential to “transform” the cell cycle inhibitory and proapoptotic action of TGF on epithelial cells, into a growth promoting and migratory response, rendering it as repressor of epithelial mesenchymal transition. Erf is also able to suppress ets- and ras-induced tumorigenicity in fibroblasts and Ewing’s Sarcoma cells. However, little is known for the role of Erf in development. Total elimination of Erf in mice leads to lethality at embryonic day E10.5 due to placental defects. Erf knockout embryos fail to undergo chorioallantoic fusion and labyrinth development. To bypass placenta defects and study the role of Erf in the embryo proper, we employed epiblast conditional mice. Here, we show that Erf is required in all three waves of embryo hematopoiesis. The first hematopoietic cells are formed in blood islands in the mouse embryo and have arisen from extraembryonic mesoderm at the neural plate stage of development at embryonic day 7.5 (E7.5) and are called the primitive wave. These primitive erythroblasts that come from the yolk sac comprise the predominant cells in the early circulating blood, resulting to erythroid, macrophage and megakaryocyte cell lineage in bloodstream. Shortly after, at embryonic day E8.25, a second wave is produced in the yolk sac, called the definitive wave and is consisted of erythroid and myeloid progenitors (EMPs). It migrates in bloodstream and finally colonize the fetal liver at embryonic day E10.5. A third wave of hematopoiesis that emerges from the aorta – gonad – mesonephros (AGM) region at E10.5, also migrates in the beginning to the fetal liver and finally the bone marrow, where it comprises the adult hematopoietic stem cells (HSC). Even though HSCs can be found in yolk sac, the AGM seems to be the major source of the adult HSCs. Mice lacking Erf in embryo proper exhibited severe anemia and died around embryonic day (E) 14.5. Erf-/- embryos had reduced peripheral blood cells from E9.5 onwards that precipitated at E14.5. Elimination of Erf resulted in both reduced and more immature blood cells at E9.5-10.5 based on hematoxylin and eosin assays in yolks sacs, counts of circulating blood cells and real-time for transcription levels of globins in circulating blood. These data indicate a defect in the primitive hematopoietic wave. In addition, reduced erythroid-myeloid progenitors and colony forming cells could be detected at peripheral blood at E10.5 based on flow cytometry and colony assays, indicating a defect in the yolk sac derived definitive hematopoietic progenitors. Liver hematopoiesis was also impaired with decreased numbers of precursor and…

Subjects/Keywords: Αναιμία; Anemia

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APA (6^th Edition):

Peraki, I. (2017). The role of Erf in mouse development. (Thesis). University of Crete (UOC); Πανεπιστήμιο Κρήτης. Retrieved from http://hdl.handle.net/10442/hedi/41243

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Peraki, Ioanna. “The role of Erf in mouse development.” 2017. Thesis, University of Crete (UOC); Πανεπιστήμιο Κρήτης. Accessed April 20, 2021. http://hdl.handle.net/10442/hedi/41243.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Peraki, Ioanna. “The role of Erf in mouse development.” 2017. Web. 20 Apr 2021.

Vancouver:

Peraki I. The role of Erf in mouse development. [Internet] [Thesis]. University of Crete (UOC); Πανεπιστήμιο Κρήτης; 2017. [cited 2021 Apr 20]. Available from: http://hdl.handle.net/10442/hedi/41243.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Peraki I. The role of Erf in mouse development. [Thesis]. University of Crete (UOC); Πανεπιστήμιο Κρήτης; 2017. Available from: http://hdl.handle.net/10442/hedi/41243

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Kansas State University

4. Boehm, Gladys M. The effect of cod liver oil and orange juice on the gastric acidity of dogs made anemic by hemorrhage.

Degree: 1929, Kansas State University

URL: http://hdl.handle.net/2097/36161

Subjects/Keywords: Anemia

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APA (6^th Edition):

Boehm, G. M. (1929). The effect of cod liver oil and orange juice on the gastric acidity of dogs made anemic by hemorrhage. (Thesis). Kansas State University. Retrieved from http://hdl.handle.net/2097/36161

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Boehm, Gladys M. “The effect of cod liver oil and orange juice on the gastric acidity of dogs made anemic by hemorrhage.” 1929. Thesis, Kansas State University. Accessed April 20, 2021. http://hdl.handle.net/2097/36161.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Boehm, Gladys M. “The effect of cod liver oil and orange juice on the gastric acidity of dogs made anemic by hemorrhage.” 1929. Web. 20 Apr 2021.

Vancouver:

Boehm GM. The effect of cod liver oil and orange juice on the gastric acidity of dogs made anemic by hemorrhage. [Internet] [Thesis]. Kansas State University; 1929. [cited 2021 Apr 20]. Available from: http://hdl.handle.net/2097/36161.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Boehm GM. The effect of cod liver oil and orange juice on the gastric acidity of dogs made anemic by hemorrhage. [Thesis]. Kansas State University; 1929. Available from: http://hdl.handle.net/2097/36161

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Kansas State University

5. Bullard, John Flower. The effect of feeding various members of the colon typhoid-enteritidis group to anemic and non-anemic pigs.

Degree: 1930, Kansas State University

URL: http://hdl.handle.net/2097/18424

Subjects/Keywords: Anemia

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APA (6^th Edition):

Bullard, J. F. (1930). The effect of feeding various members of the colon typhoid-enteritidis group to anemic and non-anemic pigs. (Thesis). Kansas State University. Retrieved from http://hdl.handle.net/2097/18424

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bullard, John Flower. “The effect of feeding various members of the colon typhoid-enteritidis group to anemic and non-anemic pigs.” 1930. Thesis, Kansas State University. Accessed April 20, 2021. http://hdl.handle.net/2097/18424.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bullard, John Flower. “The effect of feeding various members of the colon typhoid-enteritidis group to anemic and non-anemic pigs.” 1930. Web. 20 Apr 2021.

Vancouver:

Bullard JF. The effect of feeding various members of the colon typhoid-enteritidis group to anemic and non-anemic pigs. [Internet] [Thesis]. Kansas State University; 1930. [cited 2021 Apr 20]. Available from: http://hdl.handle.net/2097/18424.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bullard JF. The effect of feeding various members of the colon typhoid-enteritidis group to anemic and non-anemic pigs. [Thesis]. Kansas State University; 1930. Available from: http://hdl.handle.net/2097/18424

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Gothenburg / Göteborgs Universitet

6. Vaht, Krista. Aplastic anemia - a population-based study of epidemiology, treatment, and prognostic factors.

Degree: 2020, University of Gothenburg / Göteborgs Universitet

URL: http://hdl.handle.net/2077/64522

► Background and aims. Aplastic anemia (AA) is a rare but life-threatening disease. The introduction of immunosuppressive treatment (IST) and hematopoietic stem cell transplantation (HSCT) has… (more)

▼ Background and aims. Aplastic anemia (AA) is a rare but life-threatening disease. The introduction of immunosuppressive treatment (IST) and hematopoietic stem cell transplantation (HSCT) has considerably improved the outcome of patients with AA. However, modern-day population-based data are limited. This thesis aimed to retrospectively analyze the incidence, treatment modalities, survival, and immune markers in the bone marrow of patients diagnosed with AA in Sweden from 2000–2011. Patients and methods. Patients were included via the National Patient Registry and diagnosed according to the Camitta criteria. All data were collected from medical charts. In paper IV, immunohistochemistry was used to obtain data on regulatory T cells and macrophages in the bone marrow. Results and conclusions. We identified 257 confirmed cases, with an overall incidence of 2.35 cases per million inhabitants per year. The 5-year overall survival (OS) was >90% in patients aged up to 39 years but 38.1% in patients aged ≥60 years. Multivariate analysis showed that age ≥40 years, very severe AA, and no specific therapy were independent risk factors for inferior survival. First-line IST treated patients (n=158) showed a 47% response rate with no difference regarding the age groups or anti-thymocyte globulin (ATG) formulation. The response was significantly associated with the severity grade at the time of treatment initiation, and very severe AA patients exhibited a response rate of 22%. Sixty-eight patients underwent HSCT with a 5-year OS of 86.8%. The graft-versus-host-disease-free, relapse/rejection-free survival at 5 years was 69.1%. Patients aged ≥40 years had higher transplant-related mortality that translated into a lower 5-year OS. In paper IV, we found lower numbers of FOXP3-positive regulatory T cells in AA patients without predictive value for IST response and that patients with a higher number of CD163-positive macrophages had a better 5-year OS, but this benefit was only observed in the non-severe AA group. In conclusion, younger patients have very good long-term survival regardless of the choice of therapy, whereas the outcome for patients ≥60 years remains poor. Very severe AA patients respond poorly to ATG, which indicates the need for a different treatment approach.

Subjects/Keywords: aplastic anemia

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APA (6^th Edition):

Vaht, K. (2020). Aplastic anemia - a population-based study of epidemiology, treatment, and prognostic factors. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/64522

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Vaht, Krista. “Aplastic anemia - a population-based study of epidemiology, treatment, and prognostic factors.” 2020. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed April 20, 2021. http://hdl.handle.net/2077/64522.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Vaht, Krista. “Aplastic anemia - a population-based study of epidemiology, treatment, and prognostic factors.” 2020. Web. 20 Apr 2021.

Vancouver:

Vaht K. Aplastic anemia - a population-based study of epidemiology, treatment, and prognostic factors. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 2020. [cited 2021 Apr 20]. Available from: http://hdl.handle.net/2077/64522.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Vaht K. Aplastic anemia - a population-based study of epidemiology, treatment, and prognostic factors. [Thesis]. University of Gothenburg / Göteborgs Universitet; 2020. Available from: http://hdl.handle.net/2077/64522

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

7. Junco Guillermo, Jorge Eduardo. Identificación de los factores que contribuyen y limitan la efectividad del programa de suplementación con multimicronutrientes en la reducción de la anemia de niños menores de tres años del ámbito rural de Vinchos de Ayacucho.

Degree: 2015, Pontificia Universidad Católica del Perú

URL: http://tesis.pucp.edu.pe/repositorio/handle/123456789/6650

►

La presente tesis desarrolla una evaluación de la implementación del programa de suplementación con multimicronutrientes en un ámbito rural del país desde los mismos actores… (more)

▼

La presente tesis desarrolla una evaluación de la implementación del programa de suplementación con multimicronutrientes en un ámbito rural del país desde los mismos actores sobre sus comportamientos, actitudes y razones para comprender por qué el plan de suplementación con multimicronutrientes no está contribuyendo a la reducción de la anemia nutricional en los niños menores de tres años. El objetivo general es iidentificar los factores que estarían limitando o contribuyendo en la efectividad del “Plan de Implementación con multimicronutrientes, dirigido a niñas y niños menores de tres años de la zona rural de Vinchos - Ayacucho” durante los años 2012-2013, analizando la distribución, acceso y entrega oportuna de los micronutrientes; a fin de proponer estrategias de mejora en favor de la reducción de la anemia. La investigación realizada es un estudio de tipo cualitativo que es desarrollada a través de un estudio de caso y tiene como unidad de análisis a las madres de las niñas o niños menores de tres años beneficiarios del programa. El interés es conocer aquellos aspectos de la implementación del programa con multimicronutrientes que no están siendo bien efectivizados para contrarrestar el problema de la anemia nutricional de los niños menores de 3 años en un ámbito rural. La tesis se divide en seis capítulos, el primero presenta la delimitación del problema, su justificación y objetivos; el segundo el marco teórico referencial, donde se incluyen los enfoques para comprender mejor las intervenciones de los programas sociales de cómo se deberían implementar para fortalecer la inclusión social, la no discriminación y la participación de la comunidad en condiciones de pobreza rural, antecedentes, experiencia del uso de los multimicronutrientes en el Perú y finalmente las características geográficas, socioeconómicas y demográficas del distrito de Vinchos. En el tercero se presentan los lineamientos referidos al diseño de la investigación. El cuarto capítulo presenta los datos obtenidos mediante la aplicación de las entrevistas y realizando un análisis e interpretación de los resultados. El quinto contiene las conclusiones y recomendaciones. Finalmente, el sexto capítulo presenta la propuesta de un plan de desarrollo de capacidades y estrategia de comunicación participativa para mejorar la estrategia de intervención de la suplementación con multimicronutrientes, haciéndolo eficiente en la prevención de la anemia de la población infantil.

Tesis

Advisors/Committee Members: Pineda Medina, Javier Alejandro.

Subjects/Keywords: Nutrición.; Desnutrición.; Anemia.

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APA (6^th Edition):

Junco Guillermo, J. E. (2015). Identificación de los factores que contribuyen y limitan la efectividad del programa de suplementación con multimicronutrientes en la reducción de la anemia de niños menores de tres años del ámbito rural de Vinchos de Ayacucho. (Masters Thesis). Pontificia Universidad Católica del Perú. Retrieved from http://tesis.pucp.edu.pe/repositorio/handle/123456789/6650

Chicago Manual of Style (16^th Edition):

Junco Guillermo, Jorge Eduardo. “Identificación de los factores que contribuyen y limitan la efectividad del programa de suplementación con multimicronutrientes en la reducción de la anemia de niños menores de tres años del ámbito rural de Vinchos de Ayacucho.” 2015. Masters Thesis, Pontificia Universidad Católica del Perú. Accessed April 20, 2021. http://tesis.pucp.edu.pe/repositorio/handle/123456789/6650.

MLA Handbook (7^th Edition):

Junco Guillermo, Jorge Eduardo. “Identificación de los factores que contribuyen y limitan la efectividad del programa de suplementación con multimicronutrientes en la reducción de la anemia de niños menores de tres años del ámbito rural de Vinchos de Ayacucho.” 2015. Web. 20 Apr 2021.

Vancouver:

Junco Guillermo JE. Identificación de los factores que contribuyen y limitan la efectividad del programa de suplementación con multimicronutrientes en la reducción de la anemia de niños menores de tres años del ámbito rural de Vinchos de Ayacucho. [Internet] [Masters thesis]. Pontificia Universidad Católica del Perú 2015. [cited 2021 Apr 20]. Available from: http://tesis.pucp.edu.pe/repositorio/handle/123456789/6650.

Council of Science Editors:

Junco Guillermo JE. Identificación de los factores que contribuyen y limitan la efectividad del programa de suplementación con multimicronutrientes en la reducción de la anemia de niños menores de tres años del ámbito rural de Vinchos de Ayacucho. [Masters Thesis]. Pontificia Universidad Católica del Perú 2015. Available from: http://tesis.pucp.edu.pe/repositorio/handle/123456789/6650

Universidad de Cantabria

8. Prieto Remón, Inés. Estudio integrado sobre la anemia de Fanconi: aproximación a las bases moleculares del fallo medular y de la microftalmia.

Degree: 2013, Universidad de Cantabria

URL: http://hdl.handle.net/10902/1918

► RESUMEN: La anemia de Fanconi es una enfermedad genética rara. Presenta una gran heterogeneidad de síntomas clínicos, que van desde una aplasia medular precoz (pérdida… (more)

Subjects/Keywords: Anemia de Fanconi

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APA (6^th Edition):

Prieto Remón, I. (2013). Estudio integrado sobre la anemia de Fanconi: aproximación a las bases moleculares del fallo medular y de la microftalmia. (Doctoral Dissertation). Universidad de Cantabria. Retrieved from http://hdl.handle.net/10902/1918

Chicago Manual of Style (16^th Edition):

Prieto Remón, Inés. “Estudio integrado sobre la anemia de Fanconi: aproximación a las bases moleculares del fallo medular y de la microftalmia.” 2013. Doctoral Dissertation, Universidad de Cantabria. Accessed April 20, 2021. http://hdl.handle.net/10902/1918.

MLA Handbook (7^th Edition):

Prieto Remón, Inés. “Estudio integrado sobre la anemia de Fanconi: aproximación a las bases moleculares del fallo medular y de la microftalmia.” 2013. Web. 20 Apr 2021.

Vancouver:

Prieto Remón I. Estudio integrado sobre la anemia de Fanconi: aproximación a las bases moleculares del fallo medular y de la microftalmia. [Internet] [Doctoral dissertation]. Universidad de Cantabria; 2013. [cited 2021 Apr 20]. Available from: http://hdl.handle.net/10902/1918.

Council of Science Editors:

Prieto Remón I. Estudio integrado sobre la anemia de Fanconi: aproximación a las bases moleculares del fallo medular y de la microftalmia. [Doctoral Dissertation]. Universidad de Cantabria; 2013. Available from: http://hdl.handle.net/10902/1918

9. Musowoya, Raymond Mpanjilwa. Potential predictors of musculoskeletal manifestations in paediatric patients with sickle cell disease at the University Teaching Hospital, Lusaka.

Degree: 2019, University of Zimbabwe

URL: http://dspace.unza.zm/handle/123456789/6423

► Sickle Cell Disease (SCD) is an autosomal recessive inherited condition characterized by the inheritance of two abnormal genes coding for the formation of Haemoglobin and… (more)

▼ Sickle Cell Disease (SCD) is an autosomal recessive inherited condition characterized by the inheritance of two abnormal genes coding for the formation of Haemoglobin and one of them is Haemoglobin s. Musculoskeletal manifestations are the commonest clinical presentations of both acute and chronic cases of vaso-occlusive crisis (VOC). According to the Surgical department (of the University Teaching Hospital, Lusaka) audits done in the last 3 years, patients with SCD have been presenting very late with advanced musculoskeletal manifestations. The objective of this study was to explore the potential predictors of Musculoskeletal Manifestations in Paediatric patients presenting with Sickle Cell Disease seen at the University Teaching Hospital, Lusaka. The specific objectives were: To determine the commonest musculoskeletal manifestations in paediatric patients presenting with Sickle Cell Disease seen at University Teaching Hospital; then to determine the socio-demographic factors associated with these musculoskeletal manifestations of Sickle Cell Disease; and finally, was to establish if there was any relationship between the musculoskeletal manifestations and the potential predictors. This was an unmatched case-control study conducted at the University Teaching Hospital in Lusaka, Zambia. This study was conducted between January and April 2019. A total of 171 patients all with SCD of 16 years or below were recruited. The ‘cases’ had Musculoskeletal Manifestations, while the ‘controls’ did not have. A full assessment of these patients was done to establish these musculoskeletal manifestations and their potential predictors. The commonest musculoskeletal manifestations were found to be Chronic Osteomyelitis (29.82%), Acute Osteomyelitis (21.05%) and Avascular necrosis of the femoral head (14.04%). The median age for the cases was 9.5 years (Interquartile range (IQR), 7 – 12) while for the controls was 7 (IQR, 4 – 11). Increase in age (p=0.003), age at diagnosis (p<0.001), monthly income (p=0.03), percentage of Haemoglobin s (<0.001), frequency of vaso-occlusive crisis (p<0.001) and Aspartate transaminase (p=0.01) had a significant association with the development of musculoskeletal manifestations. However, using multivariable logistic regressions: Increase in age, frequency of vaso-occlusive crisis and the percentage of Haemoglobin s were the only variables with significant association. Musculoskeletal manifestations are common and their main predictors are: Increase in age, frequency of vaso-occlusive crisis and percentage of Haemoglobin s. Chronic Osteomyelitis is the commonest musculoskeletal manifestation in the paediatric population with SCD seen at the University Teaching Hospital, Lusaka. Keywords: Sickle Cell Disease, Sickle Cell Anaemia, Musculoskeletal Manifestation, Vaso- Occlusive Crisis

Subjects/Keywords: Sickle cell anemia

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APA (6^th Edition):

Musowoya, R. M. (2019). Potential predictors of musculoskeletal manifestations in paediatric patients with sickle cell disease at the University Teaching Hospital, Lusaka. (Thesis). University of Zimbabwe. Retrieved from http://dspace.unza.zm/handle/123456789/6423

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Musowoya, Raymond Mpanjilwa. “Potential predictors of musculoskeletal manifestations in paediatric patients with sickle cell disease at the University Teaching Hospital, Lusaka.” 2019. Thesis, University of Zimbabwe. Accessed April 20, 2021. http://dspace.unza.zm/handle/123456789/6423.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Musowoya, Raymond Mpanjilwa. “Potential predictors of musculoskeletal manifestations in paediatric patients with sickle cell disease at the University Teaching Hospital, Lusaka.” 2019. Web. 20 Apr 2021.

Vancouver:

Musowoya RM. Potential predictors of musculoskeletal manifestations in paediatric patients with sickle cell disease at the University Teaching Hospital, Lusaka. [Internet] [Thesis]. University of Zimbabwe; 2019. [cited 2021 Apr 20]. Available from: http://dspace.unza.zm/handle/123456789/6423.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Musowoya RM. Potential predictors of musculoskeletal manifestations in paediatric patients with sickle cell disease at the University Teaching Hospital, Lusaka. [Thesis]. University of Zimbabwe; 2019. Available from: http://dspace.unza.zm/handle/123456789/6423

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

10. Pereira, Jamilly Florêncio. Análise da expressão dos genes APEX1, POLΒ, RAC1 e NFKΒ em portadores de anemia falciforme.

Degree: 2019, Brazil

URL: http://www.repositorio.ufc.br/handle/riufc/46631

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Sickle cell anemia (SCA) is a hereditary hematological disease characterized by a point mutation in the beta globin gene, generating an abnormal hemoglobin called hemoglobin S (HbS), homozygous (HbSS). Treatment consists of continuous use of hydroxyurea (HU), which increases the concentration of Fetal hemoglobin (HbF). Literature reports point to a potential genotoxic effect of UH, which may increase the risk of gene instability in these patients. The APEX1 gene has different functions, acting to repair DNA single strand damage mainly induced by oxidation and regulating oxidative stress and various redox transcription factors. In this context, the aim of the present study was to evaluate the expression of APEX1, POLβ; NFκβ and RAC1, associated with laboratory data, treatment with UH and disease severity in patients with AF. This is a cross-sectional study of 98 adult patients with PA, using HU and without HU, in outpatient follow-up at Walter Cantídio University Hospital (HUWC) and a control group of 28 healthy individuals (HbAA). Epidemiological, hematological and biochemical data were obtained from the analysis of medical records. APEX1, POLβ gene expression; RAC1 and NFκβ were performed in peripheral blood by quantitative real-time polymerase chain reaction (qPCR) using TaqMan® probes. Statistical analysis was performed using the Statistical Package for Social Sciences (SPSS) version 21 software, with a significance level of 5% (p <0.05). The mean age of the patients was 32 (18-32) years, 59 (60.2%) females and 39 (39.8%) males. UH induced macrocytosis, reduction in leukocyte and neutrophil count and hemolysis parameters. Similar findings were found when stratifying patients in relation to HbF. By analyzing the expression of APEX1 POLB, RAC1 and NFKB genes regarding the use or not of HU, we observed a significant reduction of APEX1 and RAC1 expression in patients who did not use HU. Patients not using UH had lower levels of RAC1 expression when compared to patients treated with doses of 500mg / day. Patients treated with higher doses of HU had higher levels of POLB gene expression. Patients with HbF <15% had the highest levels of RAC1 gene expression and higher NFKB gene expression in Hb ≥25%. The POLB and RAC 1 (p <0.001, R = 0.1760) and NFKB and POLB (p <0.001 and R = 0.1730) genes correlated positively and moderately in patients with AF. A greater expression of APEX1 and POLB genes was observed in patients with the…

Advisors/Committee Members: Sousa, Juliana Cordeiro, Lemes, Romélia Pinheiro Gonçalves.

Subjects/Keywords: Anemia Falciforme; Hidroxiureia

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pereira, J. F. (2019). Análise da expressão dos genes APEX1, POLΒ, RAC1 e NFKΒ em portadores de anemia falciforme. (Masters Thesis). Brazil. Retrieved from http://www.repositorio.ufc.br/handle/riufc/46631

Chicago Manual of Style (16^th Edition):

Pereira, Jamilly Florêncio. “Análise da expressão dos genes APEX1, POLΒ, RAC1 e NFKΒ em portadores de anemia falciforme.” 2019. Masters Thesis, Brazil. Accessed April 20, 2021. http://www.repositorio.ufc.br/handle/riufc/46631.

MLA Handbook (7^th Edition):

Pereira, Jamilly Florêncio. “Análise da expressão dos genes APEX1, POLΒ, RAC1 e NFKΒ em portadores de anemia falciforme.” 2019. Web. 20 Apr 2021.

Vancouver:

Pereira JF. Análise da expressão dos genes APEX1, POLΒ, RAC1 e NFKΒ em portadores de anemia falciforme. [Internet] [Masters thesis]. Brazil; 2019. [cited 2021 Apr 20]. Available from: http://www.repositorio.ufc.br/handle/riufc/46631.

Council of Science Editors:

Pereira JF. Análise da expressão dos genes APEX1, POLΒ, RAC1 e NFKΒ em portadores de anemia falciforme. [Masters Thesis]. Brazil; 2019. Available from: http://www.repositorio.ufc.br/handle/riufc/46631

11. Zanis Neto, Jose. Transplante de medula ossea em anemia de Fanconi.

Degree: 2013, Brazil

URL: http://hdl.handle.net/1884/32072

► Resumo: Esta dissertacao de mestrado teve por objetivo rever a literatura sobre transplante de medula ossea em anemia de Fanconi, demonstrar a viabilidade de TMO… (more)

Subjects/Keywords: Fanconi; Anemia de

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zanis Neto, J. (2013). Transplante de medula ossea em anemia de Fanconi. (Masters Thesis). Brazil. Retrieved from http://hdl.handle.net/1884/32072

Chicago Manual of Style (16^th Edition):

Zanis Neto, Jose. “Transplante de medula ossea em anemia de Fanconi.” 2013. Masters Thesis, Brazil. Accessed April 20, 2021. http://hdl.handle.net/1884/32072.

MLA Handbook (7^th Edition):

Zanis Neto, Jose. “Transplante de medula ossea em anemia de Fanconi.” 2013. Web. 20 Apr 2021.

Vancouver:

Zanis Neto J. Transplante de medula ossea em anemia de Fanconi. [Internet] [Masters thesis]. Brazil; 2013. [cited 2021 Apr 20]. Available from: http://hdl.handle.net/1884/32072.

Council of Science Editors:

Zanis Neto J. Transplante de medula ossea em anemia de Fanconi. [Masters Thesis]. Brazil; 2013. Available from: http://hdl.handle.net/1884/32072

12. Cruz, Francisca Denyse Antonia Mendes. Caracterização físico-química de proteínas presentes na membrana de hemácias de pacientes com anemia falciforme.

Degree: 2013, Brazil

URL: http://www.repositorio.ufc.br/handle/riufc/18044

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CRUZ, F. D. A. M. Caracterização físico-química de proteínas presentes na membrana de hemácias de pacientes com anemia falciforme. 2013. 80f. Dissertação (Mestrado em Biotecnologia)… (more)

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CRUZ, F. D. A. M. Caracterização físico-química de proteínas presentes na membrana de hemácias de pacientes com anemia falciforme. 2013. 80f. Dissertação (Mestrado em Biotecnologia) - Campus de Sobral, Universidade Federal do Ceará, Sobral, 2013.

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Sickle cell anemia (SCA) is the most common hereditary disease in Brazil and is present in about 0.1 to 0.3% of the population of African origin. This disease is caused by homozygous mutation of a single nucleotide (Glu6Val gene Hb S) that modify the function of the red cell in the body, which implies changes in membrane components and, consequently, the event sickling of red blood cells, causing vaso-occlusion. In this work we aim to identify, quantify and correlate changes in erythrocyte membrane glycoproteins associated with the framework and clinical evolution of the disease, using ion exchange chromatography (IEC) and SDS-PAGE. Were performed ion exchange chromatography on membrane proteins extracted from peripheral blood erythrocytes of 31 patients with AF. The chromatograms showed significant differences in the concentration of protein present in the membranes of red blood cells when we relate absorbance / elution range between seizure freedom and volunteers without a diagnosis of AF, depending on the clinical manifestations, patients may show differences in protein concentration. 1D SDS-PAGE revealed the presence of distinct proteins, suggesting that there are differences in the type and concentration of membrane proteins in sickle erythrocytes (both in patients without crisis as a crisis), when related to those extracted from red cells not anemic. In SDS-PAGE 2D 254 spots were identified, of which 8 spots were not identified by the program TagIdent. Most spots were distributed in the pH range 7-10, with a predominance of proteins with molecular weight less than or equal to 20 kDa. Our results suggest that analysis of sickle cells by IEC, followed by SDS-PAGE (1D and 2D), allowed differentiation and partially characterize membrane proteins of erythrocytes of patients (symptomatic and asymptomatic) with AF when related to volunteers without a diagnosis of AF . Our data reinforce the variety of biomodulation related AF, suggesting that their identification is of paramount importance for the study of adhesion between these cells sickle and the endothelium, which triggers vaso-occlusion, resulting in various symptoms

A anemia falciforme (AF) é a doença hereditária mais comum no…

Advisors/Committee Members: Pinto, Vicente de Paulo Teixeira.

Subjects/Keywords: Anemia falciforme; proteínas

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cruz, F. D. A. M. (2013). Caracterização físico-química de proteínas presentes na membrana de hemácias de pacientes com anemia falciforme. (Masters Thesis). Brazil. Retrieved from http://www.repositorio.ufc.br/handle/riufc/18044

Chicago Manual of Style (16^th Edition):

Cruz, Francisca Denyse Antonia Mendes. “Caracterização físico-química de proteínas presentes na membrana de hemácias de pacientes com anemia falciforme.” 2013. Masters Thesis, Brazil. Accessed April 20, 2021. http://www.repositorio.ufc.br/handle/riufc/18044.

MLA Handbook (7^th Edition):

Cruz, Francisca Denyse Antonia Mendes. “Caracterização físico-química de proteínas presentes na membrana de hemácias de pacientes com anemia falciforme.” 2013. Web. 20 Apr 2021.

Vancouver:

Cruz FDAM. Caracterização físico-química de proteínas presentes na membrana de hemácias de pacientes com anemia falciforme. [Internet] [Masters thesis]. Brazil; 2013. [cited 2021 Apr 20]. Available from: http://www.repositorio.ufc.br/handle/riufc/18044.

Council of Science Editors:

Cruz FDAM. Caracterização físico-química de proteínas presentes na membrana de hemácias de pacientes com anemia falciforme. [Masters Thesis]. Brazil; 2013. Available from: http://www.repositorio.ufc.br/handle/riufc/18044

13. Cornejo Cari, Cinthia Pamela. Conocimientos y prácticas sobre prevención de la anemia ferropénica en madres de niños de 6 a 24 meses de un Centro de Salud Lima 2015.

Degree: 2016, National University of San Marcos

URL: http://hdl.handle.net/20.500.12672/4707

► – The present study aims entitled Objective: "Determine the knowledge and practices on the prevention of iron deficiency anemia in mothers of children 6 to… (more)

Subjects/Keywords: Anemia ferropénica - Prevención

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APA (6^th Edition):

Cornejo Cari, C. P. (2016). Conocimientos y prácticas sobre prevención de la anemia ferropénica en madres de niños de 6 a 24 meses de un Centro de Salud Lima 2015. (Thesis). National University of San Marcos. Retrieved from http://hdl.handle.net/20.500.12672/4707

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Cornejo Cari, Cinthia Pamela. “Conocimientos y prácticas sobre prevención de la anemia ferropénica en madres de niños de 6 a 24 meses de un Centro de Salud Lima 2015.” 2016. Thesis, National University of San Marcos. Accessed April 20, 2021. http://hdl.handle.net/20.500.12672/4707.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Cornejo Cari, Cinthia Pamela. “Conocimientos y prácticas sobre prevención de la anemia ferropénica en madres de niños de 6 a 24 meses de un Centro de Salud Lima 2015.” 2016. Web. 20 Apr 2021.

Vancouver:

Cornejo Cari CP. Conocimientos y prácticas sobre prevención de la anemia ferropénica en madres de niños de 6 a 24 meses de un Centro de Salud Lima 2015. [Internet] [Thesis]. National University of San Marcos; 2016. [cited 2021 Apr 20]. Available from: http://hdl.handle.net/20.500.12672/4707.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cornejo Cari CP. Conocimientos y prácticas sobre prevención de la anemia ferropénica en madres de niños de 6 a 24 meses de un Centro de Salud Lima 2015. [Thesis]. National University of San Marcos; 2016. Available from: http://hdl.handle.net/20.500.12672/4707

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Zambia

14. Wasomwe, Mumba Mercy. Problems encountered by immediate families in caring for children affected with sickle cell disease.University Teaching Hospital,Lusaka, Zambia .

Degree: 2012, University of Zambia

URL: http://hdl.handle.net/123456789/1063

► Sickle Cell Disease (SCD) is a chronic incurable genetic blood disorder that affects the Haemoglobin (Hb) within the Red Blood Cell (RBC).The disease affects millions… (more)

▼ Sickle Cell Disease (SCD) is a chronic incurable genetic blood disorder that affects the Haemoglobin (Hb) within the Red Blood Cell (RBC).The disease affects millions of people throughout the world and is one of the most prevalent and costly genetic disorder. It is also found in people of African heritage, Mediterranean, Caribbean, South and Central America, Arabian and Indian ancestry. Patients with SCD experience and endure frequent and prolonged bouts of pain and suffer from several complications associated with the disease. This requires multiple hospitalizations and causes a misery of burden. The family experiences several problems in caring and managing these children. The aim of the study was to assess the problems encountered by immediate families in caring for children affected with SCD. The study was a descriptive cross sectional study conducted at University Teaching Hospital (UTH) paediatrics department. The study sample consisted of 145 parents and guardians of children affected with SCD seen at UTH SCD outpatient clinic. The study population was sampled using non probability sampling method known as convenient sampling. A structured interview schedule consisting of both closed and open ended questions was used to collect both qualitative and quantities data. SPSS version 16 was used to analyze data. Chi square test was used to measure association between variables. The cut off point for statistical significance was 0.05. The study revealed that majority of respondents (63%) had low levels of knowledge of SCD. There was a strong association between level of education and knowledge of the disease ( p value 0.01).The level of knowledge also influenced the frequency of hospital hospitalizations The study revealed that the majority of respondents experienced financial burdens in caring for children affected with SCD and this was a major source of anxieties to the families. There was an association between monthly income and families borrowing money to take care of family needs (p value 0.01). The studies revealed that, majority of the mothers (69%) of the affected children were unable to work because of the responsibilities of caring for the affected child. This study revealed that respondents and their family members experienced psychological problems which included depression, anxiety, feelings of guilt and episode of blue moods. There was a significant association between the number of times the child had been hospitalized and depression in the parent (p value 0.01). The study revealed social problems experienced by the families of affected children ranging from poor interpersonal relationships within the home environment, stigmatization, inadequate social support and poor relationship between spouses. There was an association between joint spousal counselling on SCD and relationship between spouses being affected (p value 0.02). The investigator recommends that the Ministry of Health should put in place National SCD programmes and introduce effective and efficient IEC programmes to make…

Subjects/Keywords: Sickle cell anemia; Sickle cell anemia – Children; Meniscocytosis; Drepanocytic anemia

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wasomwe, M. M. (2012). Problems encountered by immediate families in caring for children affected with sickle cell disease.University Teaching Hospital,Lusaka, Zambia . (Thesis). University of Zambia. Retrieved from http://hdl.handle.net/123456789/1063

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wasomwe, Mumba Mercy. “Problems encountered by immediate families in caring for children affected with sickle cell disease.University Teaching Hospital,Lusaka, Zambia .” 2012. Thesis, University of Zambia. Accessed April 20, 2021. http://hdl.handle.net/123456789/1063.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wasomwe, Mumba Mercy. “Problems encountered by immediate families in caring for children affected with sickle cell disease.University Teaching Hospital,Lusaka, Zambia .” 2012. Web. 20 Apr 2021.

Vancouver:

Wasomwe MM. Problems encountered by immediate families in caring for children affected with sickle cell disease.University Teaching Hospital,Lusaka, Zambia . [Internet] [Thesis]. University of Zambia; 2012. [cited 2021 Apr 20]. Available from: http://hdl.handle.net/123456789/1063.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wasomwe MM. Problems encountered by immediate families in caring for children affected with sickle cell disease.University Teaching Hospital,Lusaka, Zambia . [Thesis]. University of Zambia; 2012. Available from: http://hdl.handle.net/123456789/1063

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

15. Perrone, Anne Caroline de Lima. Avaliação do Programa Nacional de Suplementação de ferro em gestantes de áreas rurais ribeirinhas da Amazônia.

Degree: 2018, Brazil

URL: https://www.arca.fiocruz.br/handle/icict/31199

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Made available in DSpace on 2019-01-21T20:15:36Z (GMT). No. of bitstreams: 1 Dissertação Anne Perrone.pdf: 613661 bytes, checksum: 1910a97b8adc949696726caa7cf47316 (MD5) Previous issue date: 2018

Fundação Oswaldo Cruz. Instituto de Pesquisas Leônidas e Maria Deane. Manaus, AM, Brasil.

Objetivo: Avaliar a adequação das ações preconizadas pelo Ministério da Saúde para a redução da anemia gestacional nos serviços de pré-natal de baixo risco em Unidades Básicas de Saúde Fluviais que prestam assistência às populações rurais ribeirinhas do município de Manaus. Métodos: Pesquisa avaliativa, do tipo estudo de caso único, utilizando o modelo lógico de avaliação, através de um estudo retrospectivo dos registros de consultas pré-natais. Os dados primários foram obtidos através de observações do atendimento da equipe de saúde e entrevistas semi-diretivas aos profissionais de saúde. Os dados secundários foram coletados através da caderneta da gestante e das receitas médicas. Para avaliar as ações do Programa Nacional de Suplementação de Ferro foi elaborado um modelo lógico com a inclusão dos componentes “captação de público-alvo”, “realização do hemograma”, "prescrição de suplementos”, “adequação da prescrição” e “continuidade das ações”. Resultados: Mostraram-se inadequados os componentes realização de hemograma, prescrição de suplementos e continuidade das ações; a adequação da prescrição mostrou-se parcialmente adequada e captação de público alvo mostrou-se adequada. Conclusão: As ações do PNSF na unidade de saúde avaliada mostraram-se, em parte, inadequadas, sendo necessárias melhorias, principalmente no que diz respeito à qualidade do registro de dados pois a ausência de registros resultou na inadequação da maioria dos componentes avaliados nesta pesquisa. Ademais, nota-se a necessidade de orientações aos profissionais de saúde quanto às condutas adequadas para suplementação, para que as ações do programa sejam executadas de forma correta e possam repercutir na melhoria da saúde da população.

bjective: To evaluate the adequacy of the actions recommended by the Ministry of Health for the reduction of gestational anemia in low-risk prenatal services in Basic Fluvial Health Units that provide assistance to the rural populations of the municipality of Manaus. …

Advisors/Committee Members: Gonçalves, Maria Jacirema Ferreira, Silva, Nair Chase da, Mainbourg, Evelyne Marie Therese.

Subjects/Keywords: Anemia; Anemia; Cuidado pré-natal; Anemia; Pregnant Women; Prenatal Care

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Perrone, A. C. d. L. (2018). Avaliação do Programa Nacional de Suplementação de ferro em gestantes de áreas rurais ribeirinhas da Amazônia. (Masters Thesis). Brazil. Retrieved from https://www.arca.fiocruz.br/handle/icict/31199

Chicago Manual of Style (16^th Edition):

Perrone, Anne Caroline de Lima. “Avaliação do Programa Nacional de Suplementação de ferro em gestantes de áreas rurais ribeirinhas da Amazônia.” 2018. Masters Thesis, Brazil. Accessed April 20, 2021. https://www.arca.fiocruz.br/handle/icict/31199.

MLA Handbook (7^th Edition):

Perrone, Anne Caroline de Lima. “Avaliação do Programa Nacional de Suplementação de ferro em gestantes de áreas rurais ribeirinhas da Amazônia.” 2018. Web. 20 Apr 2021.

Vancouver:

Perrone ACdL. Avaliação do Programa Nacional de Suplementação de ferro em gestantes de áreas rurais ribeirinhas da Amazônia. [Internet] [Masters thesis]. Brazil; 2018. [cited 2021 Apr 20]. Available from: https://www.arca.fiocruz.br/handle/icict/31199.

Council of Science Editors:

Perrone ACdL. Avaliação do Programa Nacional de Suplementação de ferro em gestantes de áreas rurais ribeirinhas da Amazônia. [Masters Thesis]. Brazil; 2018. Available from: https://www.arca.fiocruz.br/handle/icict/31199

16. Vaena, Marcella Martins de Vasconcelos. Análise dos fatores de risco para anemia dos recém-nascidos RH positivo filhos de gestantes aloimunizadas RH(D).

Degree: 2012, Brazil

URL: https://www.arca.fiocruz.br/handle/icict/4116

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Made available in DSpace on 2012-06-01T12:56:06Z… (more)

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Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.

A anemia fetal causada pela Doença Hemolítica Perinatal (DHPN) é responsável por quadros graves de insuficiência cardíaca e hidropisia, podendo levar a óbitos fetais. A DHPN pode ocasionar ainda sequelas neurológicas graves em recém-nascidos devido à encefalopatia bilirrubínica. No Brasil, apesar da profilaxia a incidência da doença ainda é alta. O conhecimento do histórico obstétrico e o acompanhamento pré-natal especializado, com avaliação da anemia fetal pela dopplervelocimetria, e terapêutica, com transfusão intrauterina, são capazes de aumentar a sobrevida desses pacientes e evitar sequelas. Objetivos Descrever e analisar a relação da história obstétrica e do acompanhamento pré-natal com a ocorrência de anemia no recém nascido com DHPN, identificando características clínico-epidemiológicas nestes períodos que possam estar relacionadas com a anemia no recém-nascido. Metodologia O banco de dados do ensaio clínico sobre o uso de imunoglobulina humana em anemia hemolítica por aloimunização Rh (D) forneceu os dados necessários para identificação destas relações. Dados complementares da dopplervelocimetria foram obtidos junto ao Serviço de Medicina Fetal do Instituto Fernandes Figueira (IFF). Foram considerados os recém-nascidos (RN) com diagnóstico de DHPN por anticorpo anti-Rh(D), nascidos no IFF no período de abril de 2006 a junho de 2009. Foram excluídos os RN com hidropisia fetal, idade gestacional menor que 32 semanas, asfixia grave, e os que foram submetidos à exsanguineotransfusão ao nascer. Análises bivariadas foram utilizadas para identificar as associações com a anemia. O modelo de trajetória foi utilizado para estimar as associações do histórico obstétrico e do pré-natal com a anemia. As análises estatísticas foram realizadas com os programas Epinfo e SPSS. Resultados O percentual de recém-nascidos com anemia moderada a grave ao nascer (Htc ≤35%) foi de 38%, os recém-nascidos com anemia leve (Htc entre 41% e 36%) somaram 27,2% e os não anêmicos (Htc ≥ 42%) 40%. A média da idade gestacional de início do pré-natal especializado foi de 26 semanas e 16,36% das gestantes que teriam indicação de avaliação com doppler, chegaram após 34 semanas, o que inviabilizou o acompanhamento adequado e a realização da dopplervelocimetria. O modelo de trajetória identificou correlação estatisticamente significativa entre histórico obstétrico e o período pré-natal de 37% e, entre o período pré-natal com os valores de hematócrito de cerca de 70%. Conclusão A história de filhos acometidos…

Advisors/Committee Members: Santos, Maria Cristina Pessoa dos, Gomes Junior, Saint Clair dos Santos.

Subjects/Keywords: Eritroblastose Fetal; Idade Gestacional; Anemia; Erythroblastosis; Anemia; Eritroblastose Fetal; Idade Gestacional; Anemia

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Vaena, M. M. d. V. (2012). Análise dos fatores de risco para anemia dos recém-nascidos RH positivo filhos de gestantes aloimunizadas RH(D). (Masters Thesis). Brazil. Retrieved from https://www.arca.fiocruz.br/handle/icict/4116

Chicago Manual of Style (16^th Edition):

Vaena, Marcella Martins de Vasconcelos. “Análise dos fatores de risco para anemia dos recém-nascidos RH positivo filhos de gestantes aloimunizadas RH(D).” 2012. Masters Thesis, Brazil. Accessed April 20, 2021. https://www.arca.fiocruz.br/handle/icict/4116.

MLA Handbook (7^th Edition):

Vaena, Marcella Martins de Vasconcelos. “Análise dos fatores de risco para anemia dos recém-nascidos RH positivo filhos de gestantes aloimunizadas RH(D).” 2012. Web. 20 Apr 2021.

Vancouver:

Vaena MMdV. Análise dos fatores de risco para anemia dos recém-nascidos RH positivo filhos de gestantes aloimunizadas RH(D). [Internet] [Masters thesis]. Brazil; 2012. [cited 2021 Apr 20]. Available from: https://www.arca.fiocruz.br/handle/icict/4116.

Council of Science Editors:

Vaena MMdV. Análise dos fatores de risco para anemia dos recém-nascidos RH positivo filhos de gestantes aloimunizadas RH(D). [Masters Thesis]. Brazil; 2012. Available from: https://www.arca.fiocruz.br/handle/icict/4116

17. Pereira, Sara Salgueiro. Anemia hemolítica imunomediada em cães.

Degree: 2017, RCAAP

URL: http://www.rcaap.pt/detail.jsp?id=oai:http://repositorio.utad.pt/:10348/7645

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Dissertação de Mestrado Integrado em Medicina Veterinária

A anemia hemolítica imunomediada (AHIM) constitui uma das doenças imunohematológicas mais comuns na prática clínica de pequenos animais,… (more)

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Dissertação de Mestrado Integrado em Medicina Veterinária

A anemia hemolítica imunomediada (AHIM) constitui uma das doenças imunohematológicas mais comuns na prática clínica de pequenos animais, sendo que surge mais frequentemente na espécie canina. Na sua essência, esta síndrome clínica caracteriza-se pelo surgimento de um quadro de anemia resultante de uma rápida destruição de eritrócitos, por sua vez originada por mecanismos imunomediados. A AHIM pode ser classificada de acordo com a sua origem, como primária (idiopática) ou secundária (induzida por infeção, neoplasia, fármacos ou outros). Esta classificação só se torna possível após a realização de inúmeros meios de diagnóstico já que o diagnóstico definitivo de AHIM primária apenas se consegue por exclusão de eventuais causas subjacentes e, do mesmo modo, o tratamento de AHIM secundária por eliminação do fator primário causador da doença. Os sinais clínicos variam com o grau de anemia. A base do tratamento passa pela aplicação de protocolos farmacológicos imunossupressores sendo, no entanto, necessária a aplicação de meios terapêuticos de suporte e adequados, individualmente, a cada caso. Desta forma, é uma doença que exige a maior dedicação e entrega por parte do clínico veterinário, mas também do proprietário do animal. O prognóstico varia de bom a reservado, dependendo do tipo de AHIM, manifestações clínicas e laboratoriais, sucesso do tratamento instituído, evolução do quadro clínico do animal e comprometimento do proprietário no processo de tratamento. Pelo enorme desafio que constitui desde o diagnóstico ao tratamento, a AHIM é uma doença de elevado interesse na prática da medicina interna veterinária, cuja abordagem depende de um conhecimento teórico e prático alargado, e do constante estudo e aplicação de diferentes meios diagnósticos e terapêuticos associados aos fatores de prognóstico individuais. Este trabalho foi realizado durante o período de estágio curricular, no Hospital Veterinário de Trás-os-Montes, e encontra-se estruturado em duas partes principais, nomeadamente a revisão bibliográfica do tema e a apresentação de cinco casos clínicos seguidos durante o mesmo período.

Immune-mediated hemolytic anemia (IMHA) is one of the most common imunohematologic diseases in small animal clinical practice and it tends to occur more frequently in dogs. In its essence, this clinical syndrome emerges from fast erythrocyte destruction, caused by immune-mediated mechanisms, resulting in anemia. IMHA can be classified, according to its origin, as primary (idiopathic) or secondary (induced by infection, neoplasia, drugs or others). The classification of IMHA only becomes possible after conducting countless means of diagnosis, since the diagnosis of primary IMHA can only be achieved by excluding any underlying cause. Likewise, the treatment of secondary IMHA can only be executed by eliminating the primary factor that’s causing the disease. The clinical signs vary according to the degree of anemia. The mainstay of treatment involves the application of…

Advisors/Committee Members: Oliveira, Justina Maria Prada.

Subjects/Keywords: Anemia hemolítica; Imunossupressores; Cão

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pereira, S. S. (2017). Anemia hemolítica imunomediada em cães. (Thesis). RCAAP. Retrieved from http://www.rcaap.pt/detail.jsp?id=oai:http://repositorio.utad.pt/:10348/7645

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Pereira, Sara Salgueiro. “Anemia hemolítica imunomediada em cães.” 2017. Thesis, RCAAP. Accessed April 20, 2021. http://www.rcaap.pt/detail.jsp?id=oai:http://repositorio.utad.pt/:10348/7645.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Pereira, Sara Salgueiro. “Anemia hemolítica imunomediada em cães.” 2017. Web. 20 Apr 2021.

Vancouver:

Pereira SS. Anemia hemolítica imunomediada em cães. [Internet] [Thesis]. RCAAP; 2017. [cited 2021 Apr 20]. Available from: http://www.rcaap.pt/detail.jsp?id=oai:http://repositorio.utad.pt/:10348/7645.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pereira SS. Anemia hemolítica imunomediada em cães. [Thesis]. RCAAP; 2017. Available from: http://www.rcaap.pt/detail.jsp?id=oai:http://repositorio.utad.pt/:10348/7645

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

18. Mupfudze, Tatenda Geraldine. Plasma hepcidin concentrations and factors associated with hemoglobin levels in infants and young children in Zimbabwe.

Degree: 2014, Johns Hopkins University

URL: http://jhir.library.jhu.edu/handle/1774.2/36984

► Iron metabolism is very dynamic over the first year of life. Anemia is common in sub-Saharan African infants, particularly in the context of HIV infection.… (more)

▼ Iron metabolism is very dynamic over the first year of life. Anemia is common in sub-Saharan African infants, particularly in the context of HIV infection. Hepcidin, a peptide hormone whose synthesis is simultaneously regulated by iron status and the innate immune system, has evolved as the master regulator of iron metabolism, thereby linking iron homeostasis, inflammation, infection and anemia. However little is known about normal hepcidin values in infancy, its role in the pathogenesis of anemia during infancy or its role in the pathology of HIV infection or exposure. Plasma hepcidin concentrations were higher in 3-month-old (median 9.7 ng/mL [IQR 2.5, 19.3]), than in 6-month-old (4.5 ng/mL [IQR 0.5, 7.3]) and 12-month-old infants (1.9 ng/mL [IQR 0.7, 6.2)]) (p<0.001, Kruskal–Wallis) among healthy, non-anemic Zimbabwean infants with normal iron parameters at 3 (n=60), 6 (n=47) and 12 (n=40) months of age. The correspondingly lower levels of plasma hepcidin at 6 and 12 months in healthy non-anemic infants is likely a physiologic response to mobilize iron stores and increase iron absorption to prevent anemia. Plasma hepcidin concentrations were higher in HIV-infected compared to HIV exposed uninfected (HEU) and HIV-unexposed groups throughout infancy and correlated with levels of plasma ferritin and C- reactive protein (CRP). HEU infants also had higher levels of plasma hepcidin and inflammation (alpha-1-acid glycoprotein (AGP) and CRP) compared to HIV unexposed infants. Overall, anemia had no effect on plasma hepcidin concentrations during infancy except in HIV unexposed infants. Plasma hepcidin declined with age in all groups; girls had higher plasma hepcidin concentrations than boys. Plasma hepcidin concentrations appear to be driven by inflammation in infants, as has been shown in adults. We did not find a significant association between infant and young child feeding (IYCF) indicators and hemoglobin levels in children 6-24 months using data from the 2010-11 Zimbabwe Demographic and Health Survey. However, Water, Sanitation and Hygiene (WASH) practice indicators were associated with hemoglobin levels in young Zimbabwean children adjusting for biological and social factors and warrant further investigation in randomized controlled trials. Advisors/Committee Members: Moss, William (advisor).

Subjects/Keywords: hepcidin; anemia; infancy; HIV

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mupfudze, T. G. (2014). Plasma hepcidin concentrations and factors associated with hemoglobin levels in infants and young children in Zimbabwe. (Thesis). Johns Hopkins University. Retrieved from http://jhir.library.jhu.edu/handle/1774.2/36984

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mupfudze, Tatenda Geraldine. “Plasma hepcidin concentrations and factors associated with hemoglobin levels in infants and young children in Zimbabwe.” 2014. Thesis, Johns Hopkins University. Accessed April 20, 2021. http://jhir.library.jhu.edu/handle/1774.2/36984.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mupfudze, Tatenda Geraldine. “Plasma hepcidin concentrations and factors associated with hemoglobin levels in infants and young children in Zimbabwe.” 2014. Web. 20 Apr 2021.

Vancouver:

Mupfudze TG. Plasma hepcidin concentrations and factors associated with hemoglobin levels in infants and young children in Zimbabwe. [Internet] [Thesis]. Johns Hopkins University; 2014. [cited 2021 Apr 20]. Available from: http://jhir.library.jhu.edu/handle/1774.2/36984.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mupfudze TG. Plasma hepcidin concentrations and factors associated with hemoglobin levels in infants and young children in Zimbabwe. [Thesis]. Johns Hopkins University; 2014. Available from: http://jhir.library.jhu.edu/handle/1774.2/36984

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

19. Ferrer, Patricia. MODULATION OF HOST IRON COMPARTMENTS CRITICAL TO THE MALARIA PARASITE DEVELOPMENT.

Degree: 2014, Johns Hopkins University

URL: http://jhir.library.jhu.edu/handle/1774.2/37885

► The overlap between of malaria and iron deficiency makes it difficult to treat both conditions since iron supplementation can increase malaria and malaria decreases iron… (more)

▼ The overlap between of malaria and iron deficiency makes it difficult to treat both conditions since iron supplementation can increase malaria and malaria decreases iron absorption. Iron chelators have proven antiparasitic activity. We characterized the antimalarial pharmacodynamics of the novel iron chelator FBS0701 in Plasmodium and evaluated the effect of the type and timing of iron diet on murine malaria during iron repletion. FBS0701, (S)3’’-(HO)-desazadesferrithiocin-polyether [DADFT-PE], is an oral iron chelator to treat transfusional iron overload. We showed that FBS0701 enter the erythrocytes and removes intracellular iron. FBS0701 reduced hepatic parasite load. FBS0701 interfered with artemisinin but was additive with chloroquine or quinine inhibition in the blood stage and with primaquine in the hepatic stage. FBS0701 killed early and late stage P. falciparum gametocytes. A single oral dose one day after infection cured P. yoelii 17XL infected mice. We studied the importance of iron compartmentalization on hepatic malaria infection on transgenic anemic mice: mice overexpressing hepcidin with reduced iron stores in the liver and hemoglobin deficient mice with normal hepatic iron stores. We found lower parasites on mice overexpressing hepcidin compared to non-anemic control mice (with normal liver iron). Parasite loads on hemoglobin deficient mice were not significantly different to non-anemic control mice. Finally, we studied the effect of low and high iron diets on the hepatic stage of murine malaria and the interplay of hepcidin with the hepatic infection levels. We used mice that were both anemic and iron deficient as well as non-anemic mice and gave both groups low and high iron diets for 2 and 6 weeks. Our results showed that high iron diets increased liver stage parasites in non-anemic mice and that iron supplementation predominated over a negative hepcidin effect. We partially replicated in mice the human findings from the Pemba study. In conclusion, FBS0701 could be useful as malarial prophylactic or in combination with other antimalarials. FBS0701 has the potential to be used a transmission blocking agent. Increasing liver stage may synergize with blood stage increases after iron supplementation. Therefore, iron supplementation programs in malaria endemic areas, should be accompanied of antimalarial treatment. Advisors/Committee Members: Fairweather, DeLisa (advisor).

Subjects/Keywords: Malaria; anemia; iron chelators

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ferrer, P. (2014). MODULATION OF HOST IRON COMPARTMENTS CRITICAL TO THE MALARIA PARASITE DEVELOPMENT. (Thesis). Johns Hopkins University. Retrieved from http://jhir.library.jhu.edu/handle/1774.2/37885

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ferrer, Patricia. “MODULATION OF HOST IRON COMPARTMENTS CRITICAL TO THE MALARIA PARASITE DEVELOPMENT.” 2014. Thesis, Johns Hopkins University. Accessed April 20, 2021. http://jhir.library.jhu.edu/handle/1774.2/37885.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ferrer, Patricia. “MODULATION OF HOST IRON COMPARTMENTS CRITICAL TO THE MALARIA PARASITE DEVELOPMENT.” 2014. Web. 20 Apr 2021.

Vancouver:

Ferrer P. MODULATION OF HOST IRON COMPARTMENTS CRITICAL TO THE MALARIA PARASITE DEVELOPMENT. [Internet] [Thesis]. Johns Hopkins University; 2014. [cited 2021 Apr 20]. Available from: http://jhir.library.jhu.edu/handle/1774.2/37885.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ferrer P. MODULATION OF HOST IRON COMPARTMENTS CRITICAL TO THE MALARIA PARASITE DEVELOPMENT. [Thesis]. Johns Hopkins University; 2014. Available from: http://jhir.library.jhu.edu/handle/1774.2/37885

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

20. Pedro Luis Dinon Buffon. Estudo da prevalência de anemia em idosos atendidos pela Estratégia Saúde da Família do município de Porto Alegre.

Degree: Master, 2014, Pontifícia Universidade Católica do Rio Grande do Sul

URL: http://tede.pucrs.br/tde_busca/arquivo.php?codArquivo=5425 ;

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Objetivo: Avaliar a prevalência de anemia em idosos relacionando com as condições socioeconômicas, higiênicas e sanitárias e de saúde dos idosos atendidos pela Estratégia Saúde… (more)

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Objetivo: Avaliar a prevalência de anemia em idosos relacionando com as condições socioeconômicas, higiênicas e sanitárias e de saúde dos idosos atendidos pela Estratégia Saúde da Família do município de Porto Alegre, Rio Grande do Sul, Brasil. Métodos: Estudo transversal exploratório observacional, no qual agentes comunitários de saúde aplicaram um questionário, que continha informações epidemiológicas e os pesquisadores do projeto realizaram a coleta de sangue. Este estudo faz parte do Estudo epidemiológico e clínico dos idosos atendidos pela ESF do município de Porto Alegre (EMISUS). A amostra inicial calculada para este projeto era de 1080 idosos, sendo sorteados 36 de cada uma das 30 equipes da ESF. Para este trabalho foi definido um tamanho amostral mínimo de 540 idosos, considerando 2,5% de erro aceitável para uma prevalência de anemia esperada de 10,0%. Os parâmetros hematológicos avaliados foram concentração de hemoglobina, volume corpuscular médio (VCM), concentração de hemoglobina corpuscular média (CHCM) e amplitude de distribuição das hemácias (RDW). Resultados: Foram avaliados 556 idosos com 60 anos ou mais, de ambos os sexos. A prevalência de anemia, avaliada pela dosagem de hemoglobina, foi de 8,8%, representando 10,1% para os homens e 8,1% para as mulheres. A anemia normocítica e normocrômica foi o tipo de anemia mais comumente encontrada (34,0%), sugestiva de doença crônica. Além disso, a prevalência de anemia normocítica e hipocrômica foi de 32,0%, sugerindo uma evolução da anemia por doença crônica nas fases inicias de deficiência de ferro. Na análise das condições socioeconômicas e de saúde, diferenças significativas foram encontradas em entre a faixa etária, cor, escolaridade, presença ou não de cuidador principal, internação hospitalar, doenças da tireóide, relato de fraqueza e utilização de antianêmicos. Conclusão: Inúmeros são os fatores desencadeantes dos baixos níveis de hemoglobina. Fatores como faixa etária, raça, renda mensal familiar, escolaridade, cuidados e doenças associadas são relevantes para influenciar neste acontecimento. A anemia não deve ser considerada uma condição associada somente ao processo de envelhecimento, mas sim às inúmeras doenças, que são frequentes nesta população e, portanto, merece atenção clínica adequada. A caracterização da anemia deve ser cuidadosamente realizada para auxiliar no tratamento correto.

Objective: To evaluate the prevalence of anemia among elderly people related to the socioeconomic, hygienic, sanitary and health conditions in older people attended by the Family Health Strategy (FHS) in the city of Porto Alegre, Rio Grande do Sul, Brazil. Methods: Observational, cross-sectional and exploratory study in which community health workers applied a questionnaire, that contained epidemiological information, and the project researchers collect the blood sampling. This study is part of the "Clinical and epidemiological study of the elderly people attended by the FHS in the city of Porto Alegre". The initial sample calculated for this project was 1080…

Advisors/Committee Members: Geraldo Attílio de Carli.

Subjects/Keywords: MEDICINA; GERONTOLOGIA; IDOSOS; ANEMIA; MEDICINA

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Buffon, P. L. D. (2014). Estudo da prevalência de anemia em idosos atendidos pela Estratégia Saúde da Família do município de Porto Alegre. (Masters Thesis). Pontifícia Universidade Católica do Rio Grande do Sul. Retrieved from http://tede.pucrs.br/tde_busca/arquivo.php?codArquivo=5425 ;

Chicago Manual of Style (16^th Edition):

Buffon, Pedro Luis Dinon. “Estudo da prevalência de anemia em idosos atendidos pela Estratégia Saúde da Família do município de Porto Alegre.” 2014. Masters Thesis, Pontifícia Universidade Católica do Rio Grande do Sul. Accessed April 20, 2021. http://tede.pucrs.br/tde_busca/arquivo.php?codArquivo=5425 ;.

MLA Handbook (7^th Edition):

Buffon, Pedro Luis Dinon. “Estudo da prevalência de anemia em idosos atendidos pela Estratégia Saúde da Família do município de Porto Alegre.” 2014. Web. 20 Apr 2021.

Vancouver:

Buffon PLD. Estudo da prevalência de anemia em idosos atendidos pela Estratégia Saúde da Família do município de Porto Alegre. [Internet] [Masters thesis]. Pontifícia Universidade Católica do Rio Grande do Sul; 2014. [cited 2021 Apr 20]. Available from: http://tede.pucrs.br/tde_busca/arquivo.php?codArquivo=5425 ;.

Council of Science Editors:

Buffon PLD. Estudo da prevalência de anemia em idosos atendidos pela Estratégia Saúde da Família do município de Porto Alegre. [Masters Thesis]. Pontifícia Universidade Católica do Rio Grande do Sul; 2014. Available from: http://tede.pucrs.br/tde_busca/arquivo.php?codArquivo=5425 ;

Universidade Estadual de Campinas

21. Camila Bononi de Almeida. Caracterização das fosfodiesterases (PDE) de GMPc nas celulas de linhagem eritroide e efeitos de drogas inibidoras de PDE na produção de hemoglobina fetal.

Degree: Faculdade de Ciências Médicas, 2006, Universidade Estadual de Campinas

URL: http://libdigi.unicamp.br/document/?code=vtls000415329

► Sickle cell disease (SCD) is a systemic disease with a multifaceted pathophysiology; the polymerisation of the sickle haemoglobin molecule (HbS), when deoxygenated, has many consequences… (more)

▼ Sickle cell disease (SCD) is a systemic disease with a multifaceted pathophysiology; the polymerisation of the sickle haemoglobin molecule (HbS), when deoxygenated, has many consequences that include haemolysis, inflammation, dysregulated nitric oxide (NO) homeostasis and oxidative abnormalities. Agents, such as hydroxyurea (HU), that increase levels of fetal hemoglobin (HbF), with consequent inhibition of HbS polymerization, and that may counteract other aspects of the disease?s pathophysiology characterize important therapies for the disorder. Whilst HU therapy successfully augments HbF levels in many patients, not all patients respond to treatment. Studies demonstrate that HU, when degraded, produces nitric oxide (NO), in turn activating the enzyme, soluble guanylate cyclase (GC) in erythroid lineage cells. GC converts GTP to cGMP, which acts as a second messenger for NO, possibly activating the transcription of the ?-globin gene and, consequently, increasing the concentration of HbF. Due to evidence that NO bioavailability may be decreased in SCD individuals, recent research into SCD has focused on the role of NO in the disease, particularly since this gas is an important vasodilator. The objective of this study was to investigate which family(ies) of phosphodiesterases (PDE) may mediate the degradation of cGMP in erythroid lineage cells and whether drugs that inhibit these PDEs are capable of augmenting the production of ?-globin and, consequently, HbF in erythroid cells in culture. For this, cultures of K562 erythroleukemic cells were treated with different PDE inhibitors; vinpocetine, sildenafil citrate, dipyridamole and zaprinast. In addition, cultures were also treated with the guanylate cyclase stimulator, BAY41-2272. Increased levels of cGMP were observed principally in cells treated with 10µg/ml dipyridamole and at some time-points in the presence of 10 and 50µM vinpocetine. No changes in cGMP levels were observed in cells treated with sildenafil nor with zaprinast. However, cells treated with BAY 41-2272 demonstrated augmented cGMP levels at all concentrations used. With regard to relative ?-globin gene expression, dipyridamole, vinpocetine, sildenafil and zaprinast did not increase ?-globin gene expression; in contrast, BAY 41-2272 (60 and 300nM) stimulated increased ?-globin expression after 48h of culture. The gene expressions of PDEs 1, 5 and 9 were also studied in different hematopoietic cell types and other tissues. PDE9 is expressed, at significantly higher levels, in K562 cells (erythroleukemic cells), reticulocytes and neutrophils than in numerous other cell types tested (T98G, colon, mammary, ovary, testicle, liver, skin, spleen, uterus, limphonode). Furthermore, the expression of this PDE was even higher in the reticulocytes and neutrophils of patients with SCD. In patients on HU therapy, the expression of PDE9 in reticulocytes was reversed back to levels similar to those seen in controls. In contrast, PDE9 expression in neutrophils was similar in patients on or off HU therapy. Thus, since the… Advisors/Committee Members: Alessandra Gambero, Nicola Conran Zorzetto, Fernando Ferreira Costa, Vagner de Castro, Nicola Amanda Conran Zorzetto [Orientador].

Subjects/Keywords: Anemia falciforme; Sickle cell disease

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Almeida, C. B. d. (2006). Caracterização das fosfodiesterases (PDE) de GMPc nas celulas de linhagem eritroide e efeitos de drogas inibidoras de PDE na produção de hemoglobina fetal. (Thesis). Universidade Estadual de Campinas. Retrieved from http://libdigi.unicamp.br/document/?code=vtls000415329

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Almeida, Camila Bononi de. “Caracterização das fosfodiesterases (PDE) de GMPc nas celulas de linhagem eritroide e efeitos de drogas inibidoras de PDE na produção de hemoglobina fetal.” 2006. Thesis, Universidade Estadual de Campinas. Accessed April 20, 2021. http://libdigi.unicamp.br/document/?code=vtls000415329.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Almeida, Camila Bononi de. “Caracterização das fosfodiesterases (PDE) de GMPc nas celulas de linhagem eritroide e efeitos de drogas inibidoras de PDE na produção de hemoglobina fetal.” 2006. Web. 20 Apr 2021.

Vancouver:

Almeida CBd. Caracterização das fosfodiesterases (PDE) de GMPc nas celulas de linhagem eritroide e efeitos de drogas inibidoras de PDE na produção de hemoglobina fetal. [Internet] [Thesis]. Universidade Estadual de Campinas; 2006. [cited 2021 Apr 20]. Available from: http://libdigi.unicamp.br/document/?code=vtls000415329.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Almeida CBd. Caracterização das fosfodiesterases (PDE) de GMPc nas celulas de linhagem eritroide e efeitos de drogas inibidoras de PDE na produção de hemoglobina fetal. [Thesis]. Universidade Estadual de Campinas; 2006. Available from: http://libdigi.unicamp.br/document/?code=vtls000415329

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Addis Ababa University

22. Bereket, Alemayehu. THE HEALTH IMPACT OF INTESTINAL HELMINTH INFECTIONS AMONG PODOCONIOSIS PATIENTS IN WOLAITA ZONE, SOUTHERN ETHIOPIA .

Degree: 2012, Addis Ababa University

URL: http://etd.aau.edu.et/dspace/handle/123456789/362

► Intestinal helminth infections are most common diseases of the poor and a potential cause of anemia in developing countries. Podoconiosis is a non-filarial “elephantiasis” of… (more)

▼ Intestinal helminth infections are most common diseases of the poor and a potential cause of anemia in developing countries. Podoconiosis is a non-filarial “elephantiasis” of the lower legs in farmers that work on loamy clay soil and is a chronic complication that does not have effective treatment. Soil contact being the mode of transmission of geo-helminths and the cause of podoconiosis, the aim of this study was to investigate the health impact of helminth infections on podoconiosis patients in Wolaita Zone, southern Ethiopia. A total of 480 (384 podoconiosis patients and 96 controls) study participants were enrolled in the study. The study showed an overall prevalence of 57.8% helminth parasites among podoconiosis patients and 37.5% among the controls. Out of the helminth positive podoconiosis patients, 3.9% had triple and more infections, 12.8% double and 41.1% had single infections. Among the control study participants, triple and more infections were rare (1%), whereas 7.3% double and 29.2% single infections were detected. Shoe wearing in relation to hookworm infection among the podoconiosis patients was assessed and most had no practice of appropriate shoe wearing. Hemoglobin (Hgb) and Hematocrit determination techniques used to determine anemia showed mean Hgb value between podoconiosis patients (12.85±1.69) and controls (14.71±1.69) to be significantly different (P<0.05) showing that more podoconiosis patients were anemic. On the whole, anemia was twice as likely among helminth-infected podoconiosis patients than their helminth-free counterparts. Furthermore, hookworm-infected podoconiosis patients were 3.4 times more likely to be anemic than hookworm infected non-podoconiosis individuals (P<0.05). Double helminth infections, with hookworm included, further increased the risk of being anemic among podoconiosis patients (OR=3.9, P=0.032, 95% CI=1.124, 13.523). On the other hand, the overall prevalence of intestinal geo-helminth infection decreased with increasing clinical stages of podoconiosis, implying that with severe and complicated podoconiosis, the individual would be seriously incapacitated to work on the farm and hence will have a limited contact with soil to be exposed to helminth infections. The study has provided good evidence to justify selective initiation of deworming and iron rich nutrient supplementation to improve the wellbeing of podoconiosis patients under resource poor conditions in Wolaita. Advisors/Committee Members: Beyene Petros(Prof.) (advisor).

Subjects/Keywords: Podoconiosis; Helminths; Anemia; Hookworm; Wolaita

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bereket, A. (2012). THE HEALTH IMPACT OF INTESTINAL HELMINTH INFECTIONS AMONG PODOCONIOSIS PATIENTS IN WOLAITA ZONE, SOUTHERN ETHIOPIA . (Thesis). Addis Ababa University. Retrieved from http://etd.aau.edu.et/dspace/handle/123456789/362

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bereket, Alemayehu. “THE HEALTH IMPACT OF INTESTINAL HELMINTH INFECTIONS AMONG PODOCONIOSIS PATIENTS IN WOLAITA ZONE, SOUTHERN ETHIOPIA .” 2012. Thesis, Addis Ababa University. Accessed April 20, 2021. http://etd.aau.edu.et/dspace/handle/123456789/362.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bereket, Alemayehu. “THE HEALTH IMPACT OF INTESTINAL HELMINTH INFECTIONS AMONG PODOCONIOSIS PATIENTS IN WOLAITA ZONE, SOUTHERN ETHIOPIA .” 2012. Web. 20 Apr 2021.

Vancouver:

Bereket A. THE HEALTH IMPACT OF INTESTINAL HELMINTH INFECTIONS AMONG PODOCONIOSIS PATIENTS IN WOLAITA ZONE, SOUTHERN ETHIOPIA . [Internet] [Thesis]. Addis Ababa University; 2012. [cited 2021 Apr 20]. Available from: http://etd.aau.edu.et/dspace/handle/123456789/362.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bereket A. THE HEALTH IMPACT OF INTESTINAL HELMINTH INFECTIONS AMONG PODOCONIOSIS PATIENTS IN WOLAITA ZONE, SOUTHERN ETHIOPIA . [Thesis]. Addis Ababa University; 2012. Available from: http://etd.aau.edu.et/dspace/handle/123456789/362

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Addis Ababa University

23. EDOSA, KIFLE. PREVALENCE OF ANEMIA AND ASSOCIATED FACTORS AMONG NEWLY DIAGNOSED PATIENTS WITH SOLID MALIGNANCY AT TIKUR ANBESSA SPECIALIZED HOSPITAL, RADIOTHERAPY CENTER, ADDIS ABABA, ETHIOPIA .

Degree: 2014, Addis Ababa University

URL: http://etd.aau.edu.et/dspace/handle/123456789/5684

► Background: Anemia is a common finding in cancer, which is caused by many factors. It is a major cause of morbidity in cancer patients resulting… (more)

▼ Background: Anemia is a common finding in cancer, which is caused by many factors. It is a major cause of morbidity in cancer patients resulting in impaired organ function, reduced health-related quality of life, aggressive tumor behavior, lower sensitivity to chemotherapy and radiotherapy, even shorter survival; however, little is known about the prevalence of anemia and associated factors among cancer patients during diagnosis in developing countries like Ethiopia. Objective: To assess the prevalence of anemia and associated factors among newly diagnosed patients with solid malignancy at Tikur Anbessa Specialized Hospital, Radiotherapy center, Addis Ababa, Ethiopia. Methods: Descriptive cross-sectional study was conducted from April - May, 2014 G.C. A total of 422 newly diagnosed patients with solid malignancy attending Radiotherapy center,TASH were enrolled to assess anemia prevalence and associated factors. Data was coded, entered and analyzed using SPSS version 16. Univariate analysis was applied to compute descriptive statistics for many variables. Bivariate and multivariate logistic regressions were also used to examine the effect of selected variables on prevalence of anemia and severity of anemia by the help of Odds ratio (OR) with 95% Confidence Interval (CI). P-Value < 0.05 was taken as statistically significant. Variables that showed statistically significant association (p<0.05) in Bivariate analysis, were entered and analyzed by multivariate analysis. Result: Out of 422 respondents, 285(68%) were females and 153(36%) of respondents fell into 35-49 age group with age range between 18-80 years and median age of 45. The overall prevalence of anemia across different tumor was 23% and higher anemia prevalence was noted in gynecology (37.7%) and colorectal carcinomas (26.7%). Majority of the anemic patients (68%) remained untreated for anemia. The mean trigger hemoglobin for transfusion was 7.7 g/dl. About 83.5% of anemia was mild to moderate type. Performance status (AOR = 3.344; 95% CI 1.410 – 7.927) and bleeding history (AOR = 3.628; 95% CI 1.800 – 7.314) showed statistically significant association with occurrence of anemia with p-value < 0.05.Conclusion: The overall prevalence of anemia across different tumor was 23 %, in which gynecology and colorectal showed relatively higher anemia prevalence, 37.7 % and 26.7 % respectively. Advisors/Committee Members: MINTEWAB HUSSEIN (BSc, MSc) (advisor).

Subjects/Keywords: Anemia; morbidity; cancer patients

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

EDOSA, K. (2014). PREVALENCE OF ANEMIA AND ASSOCIATED FACTORS AMONG NEWLY DIAGNOSED PATIENTS WITH SOLID MALIGNANCY AT TIKUR ANBESSA SPECIALIZED HOSPITAL, RADIOTHERAPY CENTER, ADDIS ABABA, ETHIOPIA . (Thesis). Addis Ababa University. Retrieved from http://etd.aau.edu.et/dspace/handle/123456789/5684

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

EDOSA, KIFLE. “PREVALENCE OF ANEMIA AND ASSOCIATED FACTORS AMONG NEWLY DIAGNOSED PATIENTS WITH SOLID MALIGNANCY AT TIKUR ANBESSA SPECIALIZED HOSPITAL, RADIOTHERAPY CENTER, ADDIS ABABA, ETHIOPIA .” 2014. Thesis, Addis Ababa University. Accessed April 20, 2021. http://etd.aau.edu.et/dspace/handle/123456789/5684.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

EDOSA, KIFLE. “PREVALENCE OF ANEMIA AND ASSOCIATED FACTORS AMONG NEWLY DIAGNOSED PATIENTS WITH SOLID MALIGNANCY AT TIKUR ANBESSA SPECIALIZED HOSPITAL, RADIOTHERAPY CENTER, ADDIS ABABA, ETHIOPIA .” 2014. Web. 20 Apr 2021.

Vancouver:

EDOSA K. PREVALENCE OF ANEMIA AND ASSOCIATED FACTORS AMONG NEWLY DIAGNOSED PATIENTS WITH SOLID MALIGNANCY AT TIKUR ANBESSA SPECIALIZED HOSPITAL, RADIOTHERAPY CENTER, ADDIS ABABA, ETHIOPIA . [Internet] [Thesis]. Addis Ababa University; 2014. [cited 2021 Apr 20]. Available from: http://etd.aau.edu.et/dspace/handle/123456789/5684.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

EDOSA K. PREVALENCE OF ANEMIA AND ASSOCIATED FACTORS AMONG NEWLY DIAGNOSED PATIENTS WITH SOLID MALIGNANCY AT TIKUR ANBESSA SPECIALIZED HOSPITAL, RADIOTHERAPY CENTER, ADDIS ABABA, ETHIOPIA . [Thesis]. Addis Ababa University; 2014. Available from: http://etd.aau.edu.et/dspace/handle/123456789/5684

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Porto

24. Carmo, Manuel Cardoso do. Tuberculose intestinal com profunda anemia.

Degree: 1921, Universidade do Porto

URL: http://www.rcaap.pt/detail.jsp?id=oai:repositorio-aberto.up.pt:10216/17642

Subjects/Keywords: Anemia; Tuberculose

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Carmo, M. C. d. (1921). Tuberculose intestinal com profunda anemia. (Thesis). Universidade do Porto. Retrieved from http://www.rcaap.pt/detail.jsp?id=oai:repositorio-aberto.up.pt:10216/17642

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Carmo, Manuel Cardoso do. “Tuberculose intestinal com profunda anemia.” 1921. Thesis, Universidade do Porto. Accessed April 20, 2021. http://www.rcaap.pt/detail.jsp?id=oai:repositorio-aberto.up.pt:10216/17642.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Carmo, Manuel Cardoso do. “Tuberculose intestinal com profunda anemia.” 1921. Web. 20 Apr 2021.

Vancouver:

Carmo MCd. Tuberculose intestinal com profunda anemia. [Internet] [Thesis]. Universidade do Porto; 1921. [cited 2021 Apr 20]. Available from: http://www.rcaap.pt/detail.jsp?id=oai:repositorio-aberto.up.pt:10216/17642.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Carmo MCd. Tuberculose intestinal com profunda anemia. [Thesis]. Universidade do Porto; 1921. Available from: http://www.rcaap.pt/detail.jsp?id=oai:repositorio-aberto.up.pt:10216/17642

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Porto

25. Aguiar, Álvaro Borges de. A Anemia perniciosa de Addison-Biermer.

Degree: 1935, Universidade do Porto

URL: http://www.rcaap.pt/detail.jsp?id=oai:repositorio-aberto.up.pt:10216/61754

Subjects/Keywords: Anemia perniciosa

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Aguiar, �. B. d. (1935). A Anemia perniciosa de Addison-Biermer. (Thesis). Universidade do Porto. Retrieved from http://www.rcaap.pt/detail.jsp?id=oai:repositorio-aberto.up.pt:10216/61754

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Aguiar, Álvaro Borges de. “A Anemia perniciosa de Addison-Biermer.” 1935. Thesis, Universidade do Porto. Accessed April 20, 2021. http://www.rcaap.pt/detail.jsp?id=oai:repositorio-aberto.up.pt:10216/61754.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Aguiar, Álvaro Borges de. “A Anemia perniciosa de Addison-Biermer.” 1935. Web. 20 Apr 2021.

Vancouver:

Aguiar �Bd. A Anemia perniciosa de Addison-Biermer. [Internet] [Thesis]. Universidade do Porto; 1935. [cited 2021 Apr 20]. Available from: http://www.rcaap.pt/detail.jsp?id=oai:repositorio-aberto.up.pt:10216/61754.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Aguiar �Bd. A Anemia perniciosa de Addison-Biermer. [Thesis]. Universidade do Porto; 1935. Available from: http://www.rcaap.pt/detail.jsp?id=oai:repositorio-aberto.up.pt:10216/61754

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Iowa State University

26. Hanson, Nicole Clare. Novel methods for identification and quantification of iron fortificants in cereal flours.

Degree: 2020, Iowa State University

URL: https://lib.dr.iastate.edu/etd/17973

► Iron deficiency is the most common nutrient deficiency globally. Fortification of cereal grains is a main strategy used to ameliorate global iron deficiency due to… (more)

▼ Iron deficiency is the most common nutrient deficiency globally. Fortification of cereal grains is a main strategy used to ameliorate global iron deficiency due to its safety and efficacy. For fortification to be effective, fortification programs must use appropriate iron compounds at appropriate levels. However, existing laboratory methods to identify and quantify fortificants are time consuming and costly. Our objective was to develop a quick and simple method to identify and quantify iron compounds commonly used for flour fortification. Unfortified whole wheat, refined wheat, and yellow corn flours were fortified with 20–60 mg Fe/kg flour using ferric pyrophosphate (FePP), ferrous sulfate (FeSO4), ferrous citrate (FeCit), ferrous fumarate (FeFum), sodium ferric EDTA (NaFeEDTA), and electrolytic iron (EFe). Using potassium thiocyanate (KSCN) with HCl with and without hydrogen peroxide (H2O2), we identified EFe, ferric, and ferrous fortificants. NaFeEDTA, FePP, FeSO4, FeCit, and FeFum were identified based on their solubility in water using ferrozine with and without ascorbic acid (ASC). An alternative method for identification that uses only KSCN as a chromogen was also developed but was inferior to the ferrozine method. Four blinded samples were prepared with randomly selected fortificants (EFe, NaFeEDTA, FePP, FeFum) and all were correctly identified by four personnel. For quantification, those four samples plus an additional FeSO4 sample were tested blindly. The average of each person's reported iron levels for each sample were within 10 mg Fe/kg of actual iron levels 85% of the time. Estimated iron levels from the visual method were not significantly different than iron levels from two standard quantitative methods (p > 0.05) for all the fortificants tested suggesting reliability of simple visual testing. These quick, inexpensive, and reliable methods will be useful for agencies to identify the type and amount of iron added to flour to monitor the quality of iron fortification strategies.

Subjects/Keywords: Anemia; Enrichment; Fortification; Iron

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hanson, N. C. (2020). Novel methods for identification and quantification of iron fortificants in cereal flours. (Thesis). Iowa State University. Retrieved from https://lib.dr.iastate.edu/etd/17973

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hanson, Nicole Clare. “Novel methods for identification and quantification of iron fortificants in cereal flours.” 2020. Thesis, Iowa State University. Accessed April 20, 2021. https://lib.dr.iastate.edu/etd/17973.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hanson, Nicole Clare. “Novel methods for identification and quantification of iron fortificants in cereal flours.” 2020. Web. 20 Apr 2021.

Vancouver:

Hanson NC. Novel methods for identification and quantification of iron fortificants in cereal flours. [Internet] [Thesis]. Iowa State University; 2020. [cited 2021 Apr 20]. Available from: https://lib.dr.iastate.edu/etd/17973.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hanson NC. Novel methods for identification and quantification of iron fortificants in cereal flours. [Thesis]. Iowa State University; 2020. Available from: https://lib.dr.iastate.edu/etd/17973

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Texas Southwestern Medical Center

27. Farris, Landon. Use of the Masimo Rainbow Noninvasive Hemoglobin Measurement Technology for Children with Sickle Cell Disease.

Degree: 2012, University of Texas Southwestern Medical Center

URL: http://hdl.handle.net/2152.5/1116

► PURPOSE OF STUDY: Until recently, pulse oximeters have been limited by the fact that they use two wavelengths of light to measure oxygen saturation. The… (more)

▼ PURPOSE OF STUDY: Until recently, pulse oximeters have been limited by the fact that they use two wavelengths of light to measure oxygen saturation. The use of only two wavelengths often resulted in serious errors, especially in patients with hemoglobinopathies. Although multiwavelength pulse oximeters have been the subject of research in the past, the first multiwavelength instruments did not reach the commercial medical market until 2005. More recently, the new ‘Rainbow Technology’ pulse oximeters developed by Masimo Corp., which also use multiple wavelengths, have permitted the noninvasive measurement of total hemoglobin. To further evaluate the accuracy of this new technology, we intended to test the hypothesis that the total hemoglobin as measured by the Masimo Rainbow Radical correlates with laboratory data in children with sickle cell anemia as measured by the Sysmex Automated Hematology Analyzer. METHODS USED: Hemoglobin measurements were taken at Children’s Medical Center in Dallas from patients under the age of 18 with a diagnosis of sickle cell anemia. In addition, the study limits enrollment to patients which are scheduled for routine hemoglobin measurements as part of their clinical course. A single use, flexible probe is applied on the middle finger of the hand from which blood is drawn, and the monitor is allowed to run for 3-5 minutes until the readings are stabilized. Only the readings taken at the time of the blood draw are recorded as SpHb values and used for subsequent analysis. SUMMARY OF RESULTS: 150 patients were enrolled, and the device completed measurements on 133 of the patients. The Masimo Rainbow Radical recorded a total hemoglobin measurement an average of 17 minutes from when blood was taken for laboratory analysis. The hemoglobin values as measured by the Radical (SpHb) and the Sysmex Automated Hematology Analyzer (Hb) differed by an average absolute value of 1.26 g/dL. Additionally, when the SpHb measurements are plotted against the Hb values, the Pearson Correlation Coefficient is 0.69. The mean bias was 0.8 g/dL with a standard deviation of 1.3 g/dL and limits of agreement of -1.8 to 3.4 g/dL. SpHb. CONCLUSIONS: The bias and precision of SpHb to Hb in our patients was higher than that found in healthy volunteers. This might be due to the different sensors used in adults and children, or may be due to the presence of sickle hemoglobin in our patients. Further studies are needed to clarify this issue. However, at this preliminary stage, the correlation between the Rainbow Radical and Hematology Analyzer suggests that the multiwavelength technology could be used as a substitute for routine screening hemoglobin measurement by blood draw. Advisors/Committee Members: Szmuk, Peter.

Subjects/Keywords: Oximetry; Anemia, Sickle Cell; Hemoglobins

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Farris, L. (2012). Use of the Masimo Rainbow Noninvasive Hemoglobin Measurement Technology for Children with Sickle Cell Disease. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/1116

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Farris, Landon. “Use of the Masimo Rainbow Noninvasive Hemoglobin Measurement Technology for Children with Sickle Cell Disease.” 2012. Thesis, University of Texas Southwestern Medical Center. Accessed April 20, 2021. http://hdl.handle.net/2152.5/1116.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Farris, Landon. “Use of the Masimo Rainbow Noninvasive Hemoglobin Measurement Technology for Children with Sickle Cell Disease.” 2012. Web. 20 Apr 2021.

Vancouver:

Farris L. Use of the Masimo Rainbow Noninvasive Hemoglobin Measurement Technology for Children with Sickle Cell Disease. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2012. [cited 2021 Apr 20]. Available from: http://hdl.handle.net/2152.5/1116.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Farris L. Use of the Masimo Rainbow Noninvasive Hemoglobin Measurement Technology for Children with Sickle Cell Disease. [Thesis]. University of Texas Southwestern Medical Center; 2012. Available from: http://hdl.handle.net/2152.5/1116

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

28. Simapuka, Fanwell L. A cross-sectional study of the factors contributing to anaemia in pregnancy in women attending antenatal at Arakan Camp Hospital.

Degree: 2012, University of Zimbabwe

URL: http://dspace.unza.zm/handle/123456789/1648

► Objective: To determine the factors contributing to anaemia in pregnancy at Arakan Camp Hospital.Design: A cross-sectional study of pregnant women attending antenatal clinic at Arakan… (more)

▼ Objective: To determine the factors contributing to anaemia in pregnancy at Arakan Camp Hospital.Design: A cross-sectional study of pregnant women attending antenatal clinic at Arakan Camp Hospital between March 1999 and July 1999.Setting: Arakan Camp Hospital is situated in Arakan Barracks. It has a well established antenatal centre which is supported by the Ministry of Health.Subjects: 112 pregnant women of gestation age 20 weeks and above. With the majority (94%) being below the age of 35 years. Data was collected by questionnaire based on the variables in the study. Age, Husband's occupation, HIV status, worm infestation, malaria, UTH, Syphilis, sickle cell disease were the major variables measured in the study.Main out come: Association was found between HIV infection, malaria and anaemia. Anaemia was found to be more common among the younger age group.Results: A total number of 113 respondents were recruited for the study, lout of which 112 fully completed the questionnaires. One did not complete and was thus not included in the study. This gave a response of more than 80%. The respondents ranged between 16-46 years old. The majority being in the age group of 20 - 29 years old. Thirty of the women tested positive for HIV which gave a percentage of 26.8% compared to the Lusaka Sero-positive of 26.5%, 1997, Nine tested positive for syphilis, two had hookworms (Ascaris Lumbncoids), nine had urinanary tract infection ,Anaemia was more common in women below 25 years old with the majority being in age group 15-24 years old. Anaemia and HIV infection showed a strong positive association (OR2.5 (95%), CI 1.13<OR3.18P=0.04). Malana in pregnancy had a significant association with anaemia (OR 5.13, 95% CI 4.17 < OR < 6.16 P=0.006). Exposure to worms before was not statistically significant (P=0.50). Evidence of worms in stool was also not statistically significant (Fischer exact test. 1 tailed P value =0 40).Socio-economic status (P=1.00). Accessibility to MCH facility (P=0.312). For the two variables the association to anaemia in pregnancy was statistically insignificant. Conclusion: HIV infection and malaria appear to have significant association to anaemia in pregnancy in the subjects at Arakan Camp Hospital. The prevalence of worm infestation was found to be very Jew in this study, this could be due to the prevailing sanitary conditions in the barracks. Almost everybody useslatrines and wear shoes. Socio-economic status played a major role in anaemia during pregnancy due to the availability of free bags of mealie meal and an average income of K150,000 per family. This is not the case for the rest of the country. This little gain was however defeated by the prevalence HIV and malaria during pregnancy.

Subjects/Keywords: Anemia in pregnancy – Lusaka; Zambia

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Simapuka, F. L. (2012). A cross-sectional study of the factors contributing to anaemia in pregnancy in women attending antenatal at Arakan Camp Hospital. (Thesis). University of Zimbabwe. Retrieved from http://dspace.unza.zm/handle/123456789/1648

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Simapuka, Fanwell L. “A cross-sectional study of the factors contributing to anaemia in pregnancy in women attending antenatal at Arakan Camp Hospital.” 2012. Thesis, University of Zimbabwe. Accessed April 20, 2021. http://dspace.unza.zm/handle/123456789/1648.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Simapuka, Fanwell L. “A cross-sectional study of the factors contributing to anaemia in pregnancy in women attending antenatal at Arakan Camp Hospital.” 2012. Web. 20 Apr 2021.

Vancouver:

Simapuka FL. A cross-sectional study of the factors contributing to anaemia in pregnancy in women attending antenatal at Arakan Camp Hospital. [Internet] [Thesis]. University of Zimbabwe; 2012. [cited 2021 Apr 20]. Available from: http://dspace.unza.zm/handle/123456789/1648.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Simapuka FL. A cross-sectional study of the factors contributing to anaemia in pregnancy in women attending antenatal at Arakan Camp Hospital. [Thesis]. University of Zimbabwe; 2012. Available from: http://dspace.unza.zm/handle/123456789/1648

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

29. Machiko, Alfred. Assessment of Serum Zinc,Copper and Selenium in Non-Symptomatic Sickle-Cell Anaemia Patients at the University Teaching Hospital,lusaka,Zambia.

Degree: 2016, University of Zimbabwe

URL: http://dspace.unza.zm/handle/123456789/4733

► Zinc, Copper and Selenium are important trace elements in human health and disease. They play a vital role as cofactors of enzymes such as superoxide… (more)

▼ Zinc, Copper and Selenium are important trace elements in human health and disease. They play a vital role as cofactors of enzymes such as superoxide dismutase and glutathione peroxide. These act as first line antioxidants enzymes in red blood cells and in plasma. In sickle-cell anaemia patients, the antioxidant activities of such enzymes is markedly reduced. Despite improvement in sickle-cell anaemia management, morbidity and mortality still remains significant hence the need to assess their levels. The baseline data obtained can be used for further research on the possible supplementation and nutritional options which can improve the patient’s antioxidant status and disease management. The study was aimed at determining the serum levels of Zinc, Copper and Selenium in asymptomatic sickle-cell anaemia patients at the University Teaching Hospital in Lusaka, Zambia. The study was a Case Control study. Asymptomatic participants were enrolled from the specialized Haematology and Oncology Clinic 4 at the University Teaching Hospital, Lusaka, Zambia. 4 mls of whole blood was collected from 46 sickle-cell anaemia patients and 46 Controls who did not have any major medical condition from Out-Patient Department after consent. Using Atomic Absorption Spectrometry, (ContraAA700® ANELYTIK JENA, Germany) serum levels of Zinc, Copper and Selenium were assayed and determined. STATA version 11.0 was used for data analysis. The median serum levels of Zinc in patients were lower [85.64±20.46mg/L vs 104.39±43.23mg/L; p<0.028] compared to controls. Copper levels were [150.26±54.82mg/L vs 129.49±54.16mg/L; p<0.191] in patients compared to the controls. Selenium levels were [0.082±0.041mg/L vs 0.083±0.032mg/L; p<0.380] in patients compared to the controls. There was no association between the frequency crises per last one year to the serum levels of Zinc, Copper and Selenium. Findings show that Zinc, is markedly reduced in sickle-cell anaemia patients compared to apparently health normal individuals. There was no direct association between the sickling crises frequency and levels of Zinc, Copper and Selenium.

Subjects/Keywords: Sickle cell anemia – Patients – Zambia

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Machiko, A. (2016). Assessment of Serum Zinc,Copper and Selenium in Non-Symptomatic Sickle-Cell Anaemia Patients at the University Teaching Hospital,lusaka,Zambia. (Thesis). University of Zimbabwe. Retrieved from http://dspace.unza.zm/handle/123456789/4733

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Machiko, Alfred. “Assessment of Serum Zinc,Copper and Selenium in Non-Symptomatic Sickle-Cell Anaemia Patients at the University Teaching Hospital,lusaka,Zambia.” 2016. Thesis, University of Zimbabwe. Accessed April 20, 2021. http://dspace.unza.zm/handle/123456789/4733.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Machiko, Alfred. “Assessment of Serum Zinc,Copper and Selenium in Non-Symptomatic Sickle-Cell Anaemia Patients at the University Teaching Hospital,lusaka,Zambia.” 2016. Web. 20 Apr 2021.

Vancouver:

Machiko A. Assessment of Serum Zinc,Copper and Selenium in Non-Symptomatic Sickle-Cell Anaemia Patients at the University Teaching Hospital,lusaka,Zambia. [Internet] [Thesis]. University of Zimbabwe; 2016. [cited 2021 Apr 20]. Available from: http://dspace.unza.zm/handle/123456789/4733.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Machiko A. Assessment of Serum Zinc,Copper and Selenium in Non-Symptomatic Sickle-Cell Anaemia Patients at the University Teaching Hospital,lusaka,Zambia. [Thesis]. University of Zimbabwe; 2016. Available from: http://dspace.unza.zm/handle/123456789/4733

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Vrije Universiteit Amsterdam

30. Haitjema, A. Towards Elucidating the Fanconi Anemia Network Through Genomic and Proteomic Approaches .

Degree: 2015, Vrije Universiteit Amsterdam

URL: http://hdl.handle.net/1871/53529

Subjects/Keywords: Fanconi anemia

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Haitjema, A. (2015). Towards Elucidating the Fanconi Anemia Network Through Genomic and Proteomic Approaches . (Doctoral Dissertation). Vrije Universiteit Amsterdam. Retrieved from http://hdl.handle.net/1871/53529

Chicago Manual of Style (16^th Edition):

Haitjema, A. “Towards Elucidating the Fanconi Anemia Network Through Genomic and Proteomic Approaches .” 2015. Doctoral Dissertation, Vrije Universiteit Amsterdam. Accessed April 20, 2021. http://hdl.handle.net/1871/53529.

MLA Handbook (7^th Edition):

Haitjema, A. “Towards Elucidating the Fanconi Anemia Network Through Genomic and Proteomic Approaches .” 2015. Web. 20 Apr 2021.

Vancouver:

Haitjema A. Towards Elucidating the Fanconi Anemia Network Through Genomic and Proteomic Approaches . [Internet] [Doctoral dissertation]. Vrije Universiteit Amsterdam; 2015. [cited 2021 Apr 20]. Available from: http://hdl.handle.net/1871/53529.

Council of Science Editors:

Haitjema A. Towards Elucidating the Fanconi Anemia Network Through Genomic and Proteomic Approaches . [Doctoral Dissertation]. Vrije Universiteit Amsterdam; 2015. Available from: http://hdl.handle.net/1871/53529

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