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Victoria University of Wellington
1.
Kong, Sarah Rhonda.
Imprimōtype: A new experience of analogue photography through tactility, tangibility and sacrifice.
Degree: 2015, Victoria University of Wellington
URL: http://hdl.handle.net/10063/4267 
► This thesis began as a critical response to digital photography. It takes an in depth look at the transition of photography from analogue to digital,…
(more)
▼ This thesis began as a critical response to digital photography. It takes an in depth look at the transition of photography from analogue to digital, and the impact of this transition on the culture of photography. This design-led research features a series of experiments that cross and merge the boundaries between digital and analogue photographic processes to offer an alternate experience of photography by tangibly re-evaluating the relationship between the camera and the photograph. Finally, this thesis leads to the creation of the ‘Imprimōtype,’ (Literally ‘print type’) a sacrificial camera that provides an alternate experience of photography rich in physical tangibility, tactility, anticipation, reward and emotional connection to the resulting photograph that comes only with temporal investment and connection in the photographic process.
Advisors/Committee Members: Gurevitch, Leon, Ok, Jeongbin.
Subjects/Keywords: Analogue; Experience; Tactility
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APA (6th Edition):
Kong, S. R. (2015). Imprimōtype: A new experience of analogue photography through tactility, tangibility and sacrifice. (Masters Thesis). Victoria University of Wellington. Retrieved from http://hdl.handle.net/10063/4267
Chicago Manual of Style (16th Edition):
Kong, Sarah Rhonda. “Imprimōtype: A new experience of analogue photography through tactility, tangibility and sacrifice.” 2015. Masters Thesis, Victoria University of Wellington. Accessed April 11, 2021.
http://hdl.handle.net/10063/4267.
MLA Handbook (7th Edition):
Kong, Sarah Rhonda. “Imprimōtype: A new experience of analogue photography through tactility, tangibility and sacrifice.” 2015. Web. 11 Apr 2021.
Vancouver:
Kong SR. Imprimōtype: A new experience of analogue photography through tactility, tangibility and sacrifice. [Internet] [Masters thesis]. Victoria University of Wellington; 2015. [cited 2021 Apr 11].
Available from: http://hdl.handle.net/10063/4267.
Council of Science Editors:
Kong SR. Imprimōtype: A new experience of analogue photography through tactility, tangibility and sacrifice. [Masters Thesis]. Victoria University of Wellington; 2015. Available from: http://hdl.handle.net/10063/4267
Victoria University of Wellington
2.
Cumming, Hemi.
Design and Synthesis of Simplified Analogues of Pateamine A.
Degree: 2014, Victoria University of Wellington
URL: http://hdl.handle.net/10063/8703
► Pateamine A (14) is a natural product that was extracted from a marine sponge off the coast of the South Island of New Zealand. It…
(more)
▼ Pateamine A (14) is a natural product that was extracted from a marine sponge off the coast of the South Island of New Zealand. It exhibits potent biological activity, mediated
by a number of protein targets. The most sensitive of these towards pateamine are the eIF4A isoforms, which have roles in translation of RNA into proteins and in nonsensemediated decay. The inhibition of these enzymes may be beneficial in the treatment of cancer or certain types of genetic diseases. Unfortunately, the naturally available supply of pateamine is very limited and its total synthesis is complex. This provides an imperative for the design of a synthetic strategy that would allow the preparation of simplified analogues of pateamine to gain further insight into the necessary features for activity and selectivity of the eIF4A isoforms.
Based on the principles of pharmacophore modification, chemical synthesis and the structure-activity relationships (SARs) reported by Romo and co-workers, a simplified analogue of pateamine, 107, was targeted that lacked a number of pendant methyl groups and contained a triazole in place of the thiazole.
Synthesis of the target analogue 107 was achieved through preparation of four fragments, followed by an investigation of suitable coupling reactions and the optimal order of connectivity. This included the preparation of two macrocycles that lacked the trienecontaining sidechain, and of simplified model substrates that allowed investigation of two olefination reactions (namely, the Wittig and Julia-Kocienski reactions) for the attachment of the sidechain fragment.
After substantial optimisation of the fragment preparation and connectivity, the complete synthesis of the target pateamine analogue 107 was achieved. The synthesis features: 1) a Julia Kocienski olefination between a highly functionalised three-carbon sulfone and a conjugated aldehyde to attach the sidechain; 2) copper-catalysed azide-alkyne cycloaddition (CuAAC) reaction to form the triazole; 3) ring opening of a δ-substituted α,β-unsaturated lactone to access the Z,E-dienoate moiety; and 4) Yamaguchi macrolactonisation. This synthesis represents a convergent strategy with 11 steps in the longest linear sequence, which utilises easily accessible starting materials (i.e. furan (or cis-butenediol), epichlorohydrin, ε-caprolactone and 1,3-propanediol) and reagents. The approach is also broadly applicable to the preparation of a range of analogue variants.
The simplified analogue (107) was found to have significantly lower activity, in comparison to pateamine A (14), in a growth inhibitory assay. Presuming this loss of bioactivity is at least partially caused by the incorporation of the triazole (in place of the thiazole), this raises an interesting question as to the role of the thiazole moiety in the bioactivity of pateamine A.
The adaptation of the synthetic strategy devised in this thesis to the preparation of future analogues will enable study of the mechanism of action of pateamine and related compounds, and probe the requirements for…
Advisors/Committee Members: Teesdale-Spittle, Paul, Harvey, Joanne.
Subjects/Keywords: Pateamine; Analogue; Synthesis
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APA (6th Edition):
Cumming, H. (2014). Design and Synthesis of Simplified Analogues of Pateamine A. (Doctoral Dissertation). Victoria University of Wellington. Retrieved from http://hdl.handle.net/10063/8703
Chicago Manual of Style (16th Edition):
Cumming, Hemi. “Design and Synthesis of Simplified Analogues of Pateamine A.” 2014. Doctoral Dissertation, Victoria University of Wellington. Accessed April 11, 2021.
http://hdl.handle.net/10063/8703.
MLA Handbook (7th Edition):
Cumming, Hemi. “Design and Synthesis of Simplified Analogues of Pateamine A.” 2014. Web. 11 Apr 2021.
Vancouver:
Cumming H. Design and Synthesis of Simplified Analogues of Pateamine A. [Internet] [Doctoral dissertation]. Victoria University of Wellington; 2014. [cited 2021 Apr 11].
Available from: http://hdl.handle.net/10063/8703.
Council of Science Editors:
Cumming H. Design and Synthesis of Simplified Analogues of Pateamine A. [Doctoral Dissertation]. Victoria University of Wellington; 2014. Available from: http://hdl.handle.net/10063/8703
3.
Pouilly, Sabrina.
Synthèse et évaluation du métabolisme d'analogues immunogènes de la N-acétylgalactosamine (GalNAc) : Synthesis and evaluation of the metabolism of immunogenic N-acetylgalactosamine analogs.
Degree: Docteur es, Biochimie, 2010, Université d'Orléans
URL: http://www.theses.fr/2010ORLE2058
► Les glycanes présents à la surface des cellules cancéreuses sont souvent modifiés par rapport à ceux d’une cellule saine. Or ces antigènes glucidiques n’induisent pas…
(more)
▼ Les glycanes présents à la surface des cellules cancéreuses sont souvent modifiés par rapport à ceux d’une cellule saine. Or ces antigènes glucidiques n’induisent pas de réponse immune efficace. La GalNAc est le premier sucre fixé lors de la O-glycosylation de type mucine et ainsi ce sucre entre dans la composition de nombreux antigènes tumoraux. Le but de notre travail était de préparer des analogues synthétiques de la GalNAc susceptibles d’être incorporés à la surface de cellules cancéreuses et dans les mucines synthétisées par les tumeurs, afin d’augmenter la réponse immune vis-à-vis des glycanes tumoraux. Nous avons synthétisé chimiquement des analogues de la GalNAc afin de les tester in vitro en tant que substrats de la voie de « sauvetage » de la GalNAc chez les mammifères et donc d’enzymes impliquées dans cette voie : une kinase (GK2) et une UDP-pyrophosphorylase (AGX1) humaines. Les meilleurs candidats ont permis la synthèse de différents UDP-sucres et une GalNAc-transférase (ppGalNAc T1) bovine a pu être utilisée in vitro pour transférer certains de ces analogues, à partir de leur forme activée en UDP-sucre, sur des peptides. Nous avons donc pu montrer que certains des analogues synthétisés étaient capables de s’intégrer dans la voie de sauvetage et d’être incorporés dans des peptides. Le pouvoir immunologique des glycoconjugués de type mucine ainsi formés a été étudié chez la souris après couplage de ces glycoprotéines à une protéine immunostimulante (KLH). D’autre part, des cellules de mammifères ont également été cultivées en présence de ces analogues afin de vérifier leur incorporation au niveau des glycoconjugués de la surface des cellules.
Glycans are often present at the cancerous cell surface in a modified form compared to healthy cells. However, these carbohydrate antigens don’t lead to an effective immune response. GalNAc is the first sugar attached to mucin type O-glycans and is thus a component of numerous tumor antigens. The aim of our work was to prepare synthetic GalNAc analogs able to be incorporated at the surface of cancer cell and into mucins synthesized by tumors in order to increase the immune response toward tumor glycans. We chemically synthesized GalNAc analogs to test them in vitro as substrates of enzymes involved in the mammalian GalNAc salvage pathway: a human galactokinase (GK2) and a human UDP-pyrophosphorylase (AGX1). The best candidates allowed the synthesis of the corresponding UDP-sugars further used to test the transfer of those analogs onto peptides using a bovine GalNAc transferase (ppGalNAc T1). We have shown that some synthetic analogs could be integrated in the GalNAc salvage pathway and O-linked to peptides. Immunological properties of the glycoconjugates thus formed were studied in mice after coupling to an immunostimulant protein (KLH). Moreover, mammalian cells were cultivated in the presence of these analogs in order to check their incorporation into glycoconjugates at the cell surface.
Advisors/Committee Members: Piller, Véronique (thesis director).
Subjects/Keywords: Analogue de la GalNAc; Antigènes glucidiques tumoraux; GalNAc analog; Tumor carbohydrate antigens
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APA (6th Edition):
Pouilly, S. (2010). Synthèse et évaluation du métabolisme d'analogues immunogènes de la N-acétylgalactosamine (GalNAc) : Synthesis and evaluation of the metabolism of immunogenic N-acetylgalactosamine analogs. (Doctoral Dissertation). Université d'Orléans. Retrieved from http://www.theses.fr/2010ORLE2058
Chicago Manual of Style (16th Edition):
Pouilly, Sabrina. “Synthèse et évaluation du métabolisme d'analogues immunogènes de la N-acétylgalactosamine (GalNAc) : Synthesis and evaluation of the metabolism of immunogenic N-acetylgalactosamine analogs.” 2010. Doctoral Dissertation, Université d'Orléans. Accessed April 11, 2021.
http://www.theses.fr/2010ORLE2058.
MLA Handbook (7th Edition):
Pouilly, Sabrina. “Synthèse et évaluation du métabolisme d'analogues immunogènes de la N-acétylgalactosamine (GalNAc) : Synthesis and evaluation of the metabolism of immunogenic N-acetylgalactosamine analogs.” 2010. Web. 11 Apr 2021.
Vancouver:
Pouilly S. Synthèse et évaluation du métabolisme d'analogues immunogènes de la N-acétylgalactosamine (GalNAc) : Synthesis and evaluation of the metabolism of immunogenic N-acetylgalactosamine analogs. [Internet] [Doctoral dissertation]. Université d'Orléans; 2010. [cited 2021 Apr 11].
Available from: http://www.theses.fr/2010ORLE2058.
Council of Science Editors:
Pouilly S. Synthèse et évaluation du métabolisme d'analogues immunogènes de la N-acétylgalactosamine (GalNAc) : Synthesis and evaluation of the metabolism of immunogenic N-acetylgalactosamine analogs. [Doctoral Dissertation]. Université d'Orléans; 2010. Available from: http://www.theses.fr/2010ORLE2058
4.
Ladjimi, Mohamed.
Effet du PACAP38 et de son analogue sur les processus cognitifs chez le rat : Reaction time perception and plasticity.
Degree: Docteur es, Neurosciences, 2018, Aix-Marseille; Faculté des sciences de Bizerte (Tunisie)
URL: http://www.theses.fr/2018AIXM0760
► Le PACAP38 est un polypeptide endogène secrété par le thalamus exerçant différents rôles physiologiques tels que vasodilatateur, immunomodulateur ou encore, analgésique. Selon certaines études, il…
(more)
▼ Le PACAP38 est un polypeptide endogène secrété par le thalamus exerçant différents rôles physiologiques tels que vasodilatateur, immunomodulateur ou encore, analgésique. Selon certaines études, il aurait, également, un impact sur les processus cognitifs au niveau de l’hippocampe. Cependant, son mécanisme d’action est assez peu connu. Son analogue, récemment synthétisé, a, quant à lui, été très peu étudié. Il s'agit d'une version beaucoup plus stable et avec une meilleure affinité aux récepteurs au PACAP que le peptide natif.Le travail effectué et présenté dans ce mémoire a permis de comparer les effets du PACAP38 et de son analogue sur le processus de mémorisation chez des rats ayant subit des expériences de navigation spatiale hippocampo-dépendante.Lors du test de l'objet déplacé (OLT), nous avons montré qu'une dose de 30 µg/kg de PACAP38 injecté en intraveineuse améliore la consolidation de la mémoire chez des rats souffrant de troubles cognitifs induits par une injection en intrapéritonéale de lipopolysaccharides ou d'ifenprodil. L'analogue n'a, quant à lui, pas permis de réduire ces troubles.Lors du test de la piscine de Morris, le PACAP38 a exercé un effet promnésique mais pas l'analogue.Il s'est avéré que le PACAP38 contribue à l'amélioration des processus cognitifs par son activité antioxydante, en régulant les taux de cytokines pro et anti-inflammatoires et les taux de BDNF centraux d'une manière plus efficace que celle de l'analogue.
PACAP38 is an endogenous polypeptide secreted by the thalamus. It is exerting different physiological roles such as vasodilator, immunomodulator or analgesic. According to some studies, it would also have an impact on cognitive processes in the hippocampus. However, its action mechanism is relatively unknown. Its analog, recently synthesized, has, for its part, been studied very little. It is a much more stable version with better affinity to PACAP receptors than the native peptide.The work performed compares the effects of PACAP38 and its analog on memory process in rats that had undergone hippocampo-dependent spatial navigation experiments.In the object location test (OLT), we have shown that a 30 µg/kg dose of PACAP38 injected intravenously improves memory consolidation in rats with cognitive impairment induced by intraperitoneal injection of lipopolysaccharides or ifenprodil. The analog was not able to reduce these disorders.In the Morris water maze test, PACAP38 exerted a promnesic effect but not the analog.It has been found that PACAP38 contributes to the improvement of cognitive processes by its antioxidant activity, by regulating pro and anti-inflammatory cytokine levels and central BDNF levels in a more efficient manner than the analog. .
Advisors/Committee Members: Save, Etienne (thesis director), Tebourbi, Olfa (thesis director).
Subjects/Keywords: Pacap; Analogue; Cognition; Stress oxydant; Hippocampe; Bdnf; Pacap; Analog; Cognition; Oxidative stress; Hippocampus; Bdnf; 612
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APA ·
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APA (6th Edition):
Ladjimi, M. (2018). Effet du PACAP38 et de son analogue sur les processus cognitifs chez le rat : Reaction time perception and plasticity. (Doctoral Dissertation). Aix-Marseille; Faculté des sciences de Bizerte (Tunisie). Retrieved from http://www.theses.fr/2018AIXM0760
Chicago Manual of Style (16th Edition):
Ladjimi, Mohamed. “Effet du PACAP38 et de son analogue sur les processus cognitifs chez le rat : Reaction time perception and plasticity.” 2018. Doctoral Dissertation, Aix-Marseille; Faculté des sciences de Bizerte (Tunisie). Accessed April 11, 2021.
http://www.theses.fr/2018AIXM0760.
MLA Handbook (7th Edition):
Ladjimi, Mohamed. “Effet du PACAP38 et de son analogue sur les processus cognitifs chez le rat : Reaction time perception and plasticity.” 2018. Web. 11 Apr 2021.
Vancouver:
Ladjimi M. Effet du PACAP38 et de son analogue sur les processus cognitifs chez le rat : Reaction time perception and plasticity. [Internet] [Doctoral dissertation]. Aix-Marseille; Faculté des sciences de Bizerte (Tunisie); 2018. [cited 2021 Apr 11].
Available from: http://www.theses.fr/2018AIXM0760.
Council of Science Editors:
Ladjimi M. Effet du PACAP38 et de son analogue sur les processus cognitifs chez le rat : Reaction time perception and plasticity. [Doctoral Dissertation]. Aix-Marseille; Faculté des sciences de Bizerte (Tunisie); 2018. Available from: http://www.theses.fr/2018AIXM0760
Oregon State University
5.
Drost, Brian George.
Time-based analog signal processing.
Degree: MS, Electrical and Computer Engineering, 2011, Oregon State University
URL: http://hdl.handle.net/1957/21810
► As CMOS processes size continues to shrink, a number of factors limit the ability of analog circuit performance to scale with the process. These issues…
(more)
▼ As CMOS processes size continues to shrink, a number of factors limit the ability of
analog circuit performance to scale with the process. These issues include smaller transistor intrinsic gains and lower supply voltages. However, scaling continues to increase the speed and decrease the power of digital circuits. In this thesis, an active time-based integrator is proposed to replace amplifiers. The integrator, implemented using highly digital ring oscillators, seeks to take advantage of benefits offered by technology scaling while negating the issues of low gain and low supply voltages. The proposed integrator topology is used in a 20MHz 4th order continuous-time
analog filter. Designed in a 90nm CMOS process, the time-based continuous-time filter achieves superior noise and linearity performance compared to state-of-the-art conventional active RC filters in simulations.
Advisors/Committee Members: Hanumolu, Pavan Kumar (advisor), Moon, Un-Ku (committee member).
Subjects/Keywords: Analog Filter
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APA (6th Edition):
Drost, B. G. (2011). Time-based analog signal processing. (Masters Thesis). Oregon State University. Retrieved from http://hdl.handle.net/1957/21810
Chicago Manual of Style (16th Edition):
Drost, Brian George. “Time-based analog signal processing.” 2011. Masters Thesis, Oregon State University. Accessed April 11, 2021.
http://hdl.handle.net/1957/21810.
MLA Handbook (7th Edition):
Drost, Brian George. “Time-based analog signal processing.” 2011. Web. 11 Apr 2021.
Vancouver:
Drost BG. Time-based analog signal processing. [Internet] [Masters thesis]. Oregon State University; 2011. [cited 2021 Apr 11].
Available from: http://hdl.handle.net/1957/21810.
Council of Science Editors:
Drost BG. Time-based analog signal processing. [Masters Thesis]. Oregon State University; 2011. Available from: http://hdl.handle.net/1957/21810
Wake Forest University
6.
Bergman, Sarah Jo Hymbaugh.
Biochemical Evaluation of N-Mustard Analogs of S-Adenosyl-L-Methionine in Protein Systems.
Degree: 2016, Wake Forest University
URL: http://hdl.handle.net/10339/64170
Subjects/Keywords: analog
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APA (6th Edition):
Bergman, S. J. H. (2016). Biochemical Evaluation of N-Mustard Analogs of S-Adenosyl-L-Methionine in Protein Systems. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/64170
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Bergman, Sarah Jo Hymbaugh. “Biochemical Evaluation of N-Mustard Analogs of S-Adenosyl-L-Methionine in Protein Systems.” 2016. Thesis, Wake Forest University. Accessed April 11, 2021.
http://hdl.handle.net/10339/64170.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Bergman, Sarah Jo Hymbaugh. “Biochemical Evaluation of N-Mustard Analogs of S-Adenosyl-L-Methionine in Protein Systems.” 2016. Web. 11 Apr 2021.
Vancouver:
Bergman SJH. Biochemical Evaluation of N-Mustard Analogs of S-Adenosyl-L-Methionine in Protein Systems. [Internet] [Thesis]. Wake Forest University; 2016. [cited 2021 Apr 11].
Available from: http://hdl.handle.net/10339/64170.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Bergman SJH. Biochemical Evaluation of N-Mustard Analogs of S-Adenosyl-L-Methionine in Protein Systems. [Thesis]. Wake Forest University; 2016. Available from: http://hdl.handle.net/10339/64170
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Université de Neuchâtel
7.
Bontorin Alves, Guilherme.
Matrice d'électrodes intelligentes: un outil pour améliorer
les performances spatiotemporelles des systèmes hybrides
(vivant-artificiel), en boucle fermée et en temps réel.
Degree: 2010, Université de Neuchâtel
URL: http://doc.rero.ch/record/20813
► Cette thèse présente un système bioélectronique prometteur, l’Hynet. Ce Réseau Hybride (vivant-artificiel) est conçu pour l’étude du comportement à long terme des cellules électrogénératrices, comme…
(more)
▼ Cette thèse présente un système bioélectronique
prometteur, l’Hynet. Ce Réseau Hybride (vivant-artificiel) est
conçu pour l’étude du comportement à long terme des cellules
électrogénératrices, comme les neurones et les cellules betas, en
deux aspects : l’individuel et en réseau. Il est basé sur une
boucle fermée et sur la communication en temps réel entre la
culture cellulaire et une unité artificielle (Matériel, Logiciel).
Le premier Hynet utilise des Matrices d’électrodes (MEA)
commerciales qui limitent les performances spatiotemporelles du
Hynet. Une nouvelle Matrice d’électrodes intelligente (iMEA) est
développée. Ce nouveau circuit intégré, analogique et mixte,
fournit une interface à forte densité, à forte échelle et
adaptative avec la culture. Le nouveau système améliore le
traitement des données en temps réel et une acquisition faible
bruit du signal extracellulaire.
Advisors/Committee Members: Peter (Dir.), Sylvie (Codir.).
Subjects/Keywords: Analog ASICs
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APA ·
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APA (6th Edition):
Bontorin Alves, G. (2010). Matrice d'électrodes intelligentes: un outil pour améliorer
les performances spatiotemporelles des systèmes hybrides
(vivant-artificiel), en boucle fermée et en temps réel. (Thesis). Université de Neuchâtel. Retrieved from http://doc.rero.ch/record/20813
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Bontorin Alves, Guilherme. “Matrice d'électrodes intelligentes: un outil pour améliorer
les performances spatiotemporelles des systèmes hybrides
(vivant-artificiel), en boucle fermée et en temps réel.” 2010. Thesis, Université de Neuchâtel. Accessed April 11, 2021.
http://doc.rero.ch/record/20813.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Bontorin Alves, Guilherme. “Matrice d'électrodes intelligentes: un outil pour améliorer
les performances spatiotemporelles des systèmes hybrides
(vivant-artificiel), en boucle fermée et en temps réel.” 2010. Web. 11 Apr 2021.
Vancouver:
Bontorin Alves G. Matrice d'électrodes intelligentes: un outil pour améliorer
les performances spatiotemporelles des systèmes hybrides
(vivant-artificiel), en boucle fermée et en temps réel. [Internet] [Thesis]. Université de Neuchâtel; 2010. [cited 2021 Apr 11].
Available from: http://doc.rero.ch/record/20813.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Bontorin Alves G. Matrice d'électrodes intelligentes: un outil pour améliorer
les performances spatiotemporelles des systèmes hybrides
(vivant-artificiel), en boucle fermée et en temps réel. [Thesis]. Université de Neuchâtel; 2010. Available from: http://doc.rero.ch/record/20813
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Manchester
8.
Khan, Mohammad.
Synthesis and Sequestrating Properties of Enterochelin
Analogues.
Degree: 2019, University of Manchester
URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:322603
► Acquisition of iron by siderophores is critical for the survival of many microbes. Enterochelin is a catechol siderophore that has a trilactonate macrocylic core derived…
(more)
▼ Acquisition of iron by siderophores is critical for
the survival of many microbes. Enterochelin is a catechol
siderophore that has a trilactonate macrocylic core derived from
serine that is connected to three 2, 3-dihydroxybenzoyl moieties
all of which participate in the coordination of an iron atom in a
hexadentate fashion. The work described in this thesis is concerned
with the development of a viable synthetic pathway to a sulfonamide
enterochelin analogue. Starting with L-Serine methyl ester
hydrochloride and with the use of 2,2-dibutyl-1,3,2-dioxastannolane
a synthetic pathway has been optimised for the synthesis of
3S,7S,11S)-3,7,11-tris(tritylamino)-1,5,9-trioxacyclododecane-2,6,10-trione
enabling routine preparation on a multi-gram scale. Improvements
have been made to the synthetic pathway towards the synthesis of
2,3-dimethoxybenzenesulfonyl chloride including a one-step
conversion of tert-butyl (2,3-dimethoxyphenyl) carbamate to
2,3-dimethoxyanaline hydrochloride using HCl in
dioxane.
Advisors/Committee Members: WHITEHEAD, ROGER RC, Quayle, Peter, Whitehead, Roger.
Subjects/Keywords: catechol; siderophores; macrocycle; Enterochelin analogue
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APA (6th Edition):
Khan, M. (2019). Synthesis and Sequestrating Properties of Enterochelin
Analogues. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:322603
Chicago Manual of Style (16th Edition):
Khan, Mohammad. “Synthesis and Sequestrating Properties of Enterochelin
Analogues.” 2019. Doctoral Dissertation, University of Manchester. Accessed April 11, 2021.
http://www.manchester.ac.uk/escholar/uk-ac-man-scw:322603.
MLA Handbook (7th Edition):
Khan, Mohammad. “Synthesis and Sequestrating Properties of Enterochelin
Analogues.” 2019. Web. 11 Apr 2021.
Vancouver:
Khan M. Synthesis and Sequestrating Properties of Enterochelin
Analogues. [Internet] [Doctoral dissertation]. University of Manchester; 2019. [cited 2021 Apr 11].
Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:322603.
Council of Science Editors:
Khan M. Synthesis and Sequestrating Properties of Enterochelin
Analogues. [Doctoral Dissertation]. University of Manchester; 2019. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:322603
Victoria University of Wellington
9.
Bayley, Oliver.
Synthesis of Novel Pyran Fragments to Incorporate into Peloruside Analogues.
Degree: 2019, Victoria University of Wellington
URL: http://hdl.handle.net/10063/8124
► Cancer is currently the second largest cause of death globally, leading to a high demand for new and effective chemotherapeutics. For years, natural products have…
(more)
▼ Cancer is currently the second largest cause of death globally, leading to a high demand for new and effective chemotherapeutics. For years, natural products have been used as a source of new bioactive compounds; of particular interest in this context, as a source of new chemotherapeutics. One chemotherapeutic candidate which has attracted significant attention in synthetic and medicinal chemistry communities, is peloruside A. Peloruside A is a bioactive secondary metabolite isolated from the New Zealand marine sponge Mycale hentscheli. Since its discovery, peloruside A has shown great promise in cancer studies both in vivo and in vitro with effects observed even at nanomolar concentrations. These chemotherapeutic effects have been shown to occur by halting cell division at the G2/M checkpoint via microtubule stabilisation. Of particular interest is that this stabilisation occurs in a manner distinct from that of the already established taxane class of microtubule stabilising drugs. This means that peloruside A is able to offer both inhibition of cell division in Taxol® resistant cells and synergistic inhibition alongside the current taxane drugs. Since peloruside A is not abundantly available from its natural source, there is a strong incentive for the development of new synthetic strategies for peloruside A production. Unfortunately attempts at aquaculture and attempts at developing an industrial scale synthesis have both proven unsuccessful thus far. In an attempt to overcome some of the difficulties with the scale up of peloruside, analogues have been developed that are intended to have similar bioactivity to peloruside A but simpler, more concise, synthetic routes. These analogues will also enable further elucidation of the binding properties of peloruside A. This project focuses on the generation of a functionalised pyran fragment, starting from a simple carbohydrate, that may be incorporated into the proposed analogues.
Advisors/Committee Members: Teesdale-Spittle, Paul, Harvey, Joanne.
Subjects/Keywords: Organic Synthesis; Drug Analogue; Peloruside
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APA (6th Edition):
Bayley, O. (2019). Synthesis of Novel Pyran Fragments to Incorporate into Peloruside Analogues. (Masters Thesis). Victoria University of Wellington. Retrieved from http://hdl.handle.net/10063/8124
Chicago Manual of Style (16th Edition):
Bayley, Oliver. “Synthesis of Novel Pyran Fragments to Incorporate into Peloruside Analogues.” 2019. Masters Thesis, Victoria University of Wellington. Accessed April 11, 2021.
http://hdl.handle.net/10063/8124.
MLA Handbook (7th Edition):
Bayley, Oliver. “Synthesis of Novel Pyran Fragments to Incorporate into Peloruside Analogues.” 2019. Web. 11 Apr 2021.
Vancouver:
Bayley O. Synthesis of Novel Pyran Fragments to Incorporate into Peloruside Analogues. [Internet] [Masters thesis]. Victoria University of Wellington; 2019. [cited 2021 Apr 11].
Available from: http://hdl.handle.net/10063/8124.
Council of Science Editors:
Bayley O. Synthesis of Novel Pyran Fragments to Incorporate into Peloruside Analogues. [Masters Thesis]. Victoria University of Wellington; 2019. Available from: http://hdl.handle.net/10063/8124
Victoria University of Wellington
10.
Brown, Sarah.
Design and Synthesis of a Highly Simplified Pateamine Analogue.
Degree: 2016, Victoria University of Wellington
URL: http://hdl.handle.net/10063/5246
► Pateamine (1) is a natural product from the marine sponge Mycale hentscheli that exhibits potent anticancer properties, and has potential as an antiviral agent, and…
(more)
▼ Pateamine (1) is a natural product from the marine sponge Mycale hentscheli that exhibits potent anticancer properties, and has potential as an antiviral agent, and in preventing the muscle wasting disorder cachexia. This biological activity of pateamine is due to its ability to inhibit the eukaryotic initiation factor eIF4A, which leads to the formation of stress granules, the inhibition of protein synthesis, and ultimately cell death. Unfortunately, pateamine is obtained in very small amounts from Mycale hentscheli; thus, it is necessary to synthesise pateamine and novel structural analogues in the laboratory. Previously a separate binding and scaffolding domain of pateamine was proposed, which led to the synthesis of a simplified des-methyl des- amino analogue that reduced the number of synthetic steps compared to pateamine while retaining its biological activity. This was followed by the synthesis of a simplified triazole- containing analogue 9 6 ; unfortunately, this exhibited substantially reduced bioactivity compared to pateamine, and it is therefore necessary to determine if the reduction in bioactivity was due to the replacement of the thiazole ring with a triazole ring, or due to the removal of key methyl groups of pateamine. Thus, the thiazole-containing analogue of 96 is deemed to be an important synthetic target.
In this Master’s project a highly simplified side chain-free analogue 130 was synthesised, which laid the groundwork for future synthesis of a thiazole-containing analogue of 96. The synthesis of 130 was achieved through a convergent synthesis with one commercially available and two prepared fragments. Particular attention was paid to the development of an efficient thiazole formation methodology, as well as optimising fragment synthesis and coupling reactions. Determination of the binding of analogue 130 with eIF4A using a competitive bioactivity assay in the presence of pateamine was then undertaken, which showed that either 130 does not bind to eIF4A or that it binds non-covalently and is then displaced by pateamine.
Advisors/Committee Members: Teesdale-Spittle, Paul, Harvey, Joanne.
Subjects/Keywords: Pateamine; Natural product; Analogue
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APA (6th Edition):
Brown, S. (2016). Design and Synthesis of a Highly Simplified Pateamine Analogue. (Masters Thesis). Victoria University of Wellington. Retrieved from http://hdl.handle.net/10063/5246
Chicago Manual of Style (16th Edition):
Brown, Sarah. “Design and Synthesis of a Highly Simplified Pateamine Analogue.” 2016. Masters Thesis, Victoria University of Wellington. Accessed April 11, 2021.
http://hdl.handle.net/10063/5246.
MLA Handbook (7th Edition):
Brown, Sarah. “Design and Synthesis of a Highly Simplified Pateamine Analogue.” 2016. Web. 11 Apr 2021.
Vancouver:
Brown S. Design and Synthesis of a Highly Simplified Pateamine Analogue. [Internet] [Masters thesis]. Victoria University of Wellington; 2016. [cited 2021 Apr 11].
Available from: http://hdl.handle.net/10063/5246.
Council of Science Editors:
Brown S. Design and Synthesis of a Highly Simplified Pateamine Analogue. [Masters Thesis]. Victoria University of Wellington; 2016. Available from: http://hdl.handle.net/10063/5246
University of Victoria
11.
Gagnon, Laurence.
Oroclines, their scale and tectonic requirements: Insights from thermo-mechanical analogue models.
Degree: School of Earth and Ocean Sciences, 2014, University of Victoria
URL: http://hdl.handle.net/1828/5174
► We use scaled 3-D thermo-mechanical analogue models to investigate the formation of oroclines (originally linear orogens now curved in map view by buckling about vertical…
(more)
▼ We use scaled 3-D thermo-mechanical analogue models to investigate the formation of oroclines (originally linear orogens now curved in map view by buckling about vertical axes). The experimental setup consists of a tank of water (the asthenosphere) on top of which rest hydrocarbon plates (the lithosphere) with strain-softening behaviours and thermo-dependent elasto-plastic properties. An electric heating element below and 4 infrared lights above produce a constant vertical (geo)thermal gradient in the plates. A horizontal piston drives constant plate motion and gives rise to a compressional stress regime. Geometric, kinematic and dynamic variables are calibrated in accordance with a set of scaling laws and proper plate composition.
Our results suggest that oroclinal buckling involves the entire lithosphere and cannot be confined to the crust only. A wide range of syn-oroclinal structures developed during buckling, including thin- to thick-skinned thrust belts, transform faults and extensional structures, as well as extensional basins and subduction zones in the lithosphere adjacent to the ribbons. During oroclinal buckling, a thrust belt forms upon complete closure of the interlimb region and is attributable to the trailing orocline limb overthrusting the leading orocline limb. An analogous syn-oroclinal thrust system characterizes the Central Iberian Orocline (CIO) of the Variscan orogen in Iberia where the north limb of the west-convex orocline exposes recumbent north-verging folds while the overriding south limb bears upright to gently north-verging folds. Our results imply that these structures developed during final closure of the CIO, and indicate that the north- and south- limbs of the CIO constitute the leading- and trailing-limbs, respectively, of an orocline that formed by overall northward translation. Modelling of magmatic arcs rotating about vertical axes yields late stage transform faults that bisect the buckling arcs. This outcome is analogous to the Panama Canal fault zone that severs the buckled Panamanian Isthmus. The hinge zones of modeled oroclines are the sites of subduction initiation, similar to subduction initiation of the Caribbean plate beneath the convex to the north, North Panamanian orocline, and of oceanic lithosphere from the Ionian Sea beneath the Calabrian orocline of Sicily.
Advisors/Committee Members: Johnston, Stephen T. (supervisor).
Subjects/Keywords: orocline; analogue modeling; structural geology
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APA (6th Edition):
Gagnon, L. (2014). Oroclines, their scale and tectonic requirements: Insights from thermo-mechanical analogue models. (Masters Thesis). University of Victoria. Retrieved from http://hdl.handle.net/1828/5174
Chicago Manual of Style (16th Edition):
Gagnon, Laurence. “Oroclines, their scale and tectonic requirements: Insights from thermo-mechanical analogue models.” 2014. Masters Thesis, University of Victoria. Accessed April 11, 2021.
http://hdl.handle.net/1828/5174.
MLA Handbook (7th Edition):
Gagnon, Laurence. “Oroclines, their scale and tectonic requirements: Insights from thermo-mechanical analogue models.” 2014. Web. 11 Apr 2021.
Vancouver:
Gagnon L. Oroclines, their scale and tectonic requirements: Insights from thermo-mechanical analogue models. [Internet] [Masters thesis]. University of Victoria; 2014. [cited 2021 Apr 11].
Available from: http://hdl.handle.net/1828/5174.
Council of Science Editors:
Gagnon L. Oroclines, their scale and tectonic requirements: Insights from thermo-mechanical analogue models. [Masters Thesis]. University of Victoria; 2014. Available from: http://hdl.handle.net/1828/5174
University of St. Andrews
12.
Robertson, Scott James.
Hawking radiation in dispersive media
.
Degree: 2011, University of St. Andrews
URL: http://hdl.handle.net/10023/1900
► Hawking radiation, despite its presence in theoretical physics for over thirty years, remains elusive and undetected. It also suffers, in its original context of gravitational…
(more)
▼ Hawking radiation, despite its presence in theoretical physics for over thirty years, remains elusive and undetected. It also suffers, in its original context of gravitational black holes, from conceptual difficulties. Of particular note is the trans-Planckian problem, which is concerned with the apparent origin of the radiation in absurdly high frequencies. In order to gain better theoretical understanding and, it is hoped, experimental verification of Hawking radiation, much study is being devoted to systems which model the spacetime geometry of black holes, and which, by analogy, are also thought to emit Hawking radiation. These analogue systems typically exhibit dispersion, which regularizes the wave behaviour at the horizon but does not lend itself well to analytic treatment, thus rendering Hawking’s prediction less secure. A general analytic method for dealing
with Hawking radiation in dispersive systems has proved difficult to find.
This thesis presents new numerical and analytic results for Hawking emission spectra in dispersive systems. It examines two black-hole analogue systems: it begins by introducing the well-known acoustic model, presenting some original results in that context; then, through analogy with the acoustic model, goes on to develop the lesser-known fibre-optical model. The following original results are presented in the context of both of these models:
• an analytic expression for the low-frequency temperature is found for a hyperbolic tangent background profile, valid in the entire parameter space; it is well-known that the spectrum is approximately thermal at low frequencies, but a universally valid expression for the corresponding temperature is an original development;
• an analytic expression for the spectrum, valid over almost the entire frequency
range, when the velocity profile parameters lie in the regime where the low-frequency
temperature is given by the Hawking prediction; previous work has focused on the
low-frequency thermal spectrum and the characterization of the deviations from
thermality, rather than a single analytic expression; and
• a new unexplored regime where no group-velocity horizon exists is examined; the
Hawking spectra are found to be non-zero here, but also highly non-thermal, and
are found, in the limit of small deviations, to vary with the square of the maximum
deviation; the analytic expression for the case with a horizon is found to carry over
to this new regime, with appropriate modifications.
Furthermore, the thesis examines the results of a classical frequency-shifting experiment
in the context of fibre-optical horizons. The theory of this process is presented for both a constant-velocity and a constantly-decelerating pulse, the latter case taking account of the Raman effect. The resulting spectra are at least qualititively explained, but there is a discrepancy between theory and experiment that has not yet been accounted for.
Advisors/Committee Members: Leonhardt, Ulf (advisor).
Subjects/Keywords: Quantum vacuum;
Analogue gravity
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APA (6th Edition):
Robertson, S. J. (2011). Hawking radiation in dispersive media
. (Thesis). University of St. Andrews. Retrieved from http://hdl.handle.net/10023/1900
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Robertson, Scott James. “Hawking radiation in dispersive media
.” 2011. Thesis, University of St. Andrews. Accessed April 11, 2021.
http://hdl.handle.net/10023/1900.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Robertson, Scott James. “Hawking radiation in dispersive media
.” 2011. Web. 11 Apr 2021.
Vancouver:
Robertson SJ. Hawking radiation in dispersive media
. [Internet] [Thesis]. University of St. Andrews; 2011. [cited 2021 Apr 11].
Available from: http://hdl.handle.net/10023/1900.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Robertson SJ. Hawking radiation in dispersive media
. [Thesis]. University of St. Andrews; 2011. Available from: http://hdl.handle.net/10023/1900
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University College Cork
13.
O'Sullivan, Gerald.
Investigation and design of key circuit blocks in a 10 bit SAR ADC at 100 MS/s.
Degree: 2020, University College Cork
URL: http://hdl.handle.net/10468/10609
► The work in this thesis is based on the investigation and design of key circuit blocks in a high speed, high resolution SAR ADC in…
(more)
▼ The work in this thesis is based on the investigation and design of key circuit blocks in a high speed, high resolution SAR ADC in TSMC’s 28nm technology. The research carried out analyses the circuit limitations of the switched capacitor DAC and the settling problems of the reference voltage associated with a switched capacitor scheme.
The switched capacitor DAC is a critical block for overall ADC performance and various trade-offs are weighed up before discussing the layout of the split capacitor DAC implemented in the project, from unit capacitor up to top level routing. It also investigates the main sources of error using this topology and implements effective ways of mitigating these errors. The schematic design of DAC switches is also carried out and the results section discusses the top level linearity performance of the DAC.
This work also focuses on detailed analysis and implementation of a reference buffer circuit solution that is capable of supplying a reference voltage that is highly accurate and can settle in enough time for the high speed and high resolution specifications required by the SAR ADC. Various solutions were comprehensively investigated for this problem and the design of the chosen flipped voltage follower topology was implemented in schematic and layout. It was subsequently simulated at schematic and extracted parasitics level to verify its functionality and determine its overall performance. Finally, the work done in each block is verified in the context of the whole ADC by top level schematic and extracted layout simulation.
Advisors/Committee Members: McCarthy, Kevin G..
Subjects/Keywords: Microelectronics; Analogue electronics; Data conversion
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APA (6th Edition):
O'Sullivan, G. (2020). Investigation and design of key circuit blocks in a 10 bit SAR ADC at 100 MS/s. (Thesis). University College Cork. Retrieved from http://hdl.handle.net/10468/10609
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
O'Sullivan, Gerald. “Investigation and design of key circuit blocks in a 10 bit SAR ADC at 100 MS/s.” 2020. Thesis, University College Cork. Accessed April 11, 2021.
http://hdl.handle.net/10468/10609.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
O'Sullivan, Gerald. “Investigation and design of key circuit blocks in a 10 bit SAR ADC at 100 MS/s.” 2020. Web. 11 Apr 2021.
Vancouver:
O'Sullivan G. Investigation and design of key circuit blocks in a 10 bit SAR ADC at 100 MS/s. [Internet] [Thesis]. University College Cork; 2020. [cited 2021 Apr 11].
Available from: http://hdl.handle.net/10468/10609.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
O'Sullivan G. Investigation and design of key circuit blocks in a 10 bit SAR ADC at 100 MS/s. [Thesis]. University College Cork; 2020. Available from: http://hdl.handle.net/10468/10609
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of New South Wales
14.
Enosi Tuipulotu, Daniel.
Norovirus antiviral discovery: host-modulators and direct-acting antivirals.
Degree: Biotechnology & Biomolecular Sciences, 2018, University of New South Wales
URL: http://handle.unsw.edu.au/1959.4/62681
;
https://unsworks.unsw.edu.au/fapi/datastream/unsworks:58917/SOURCE02?view=true
► Human norovirus is a leading cause of acute gastroenteritis (AGE) worldwide and is estimated to be responsible for over 200,000 deaths each year. Norovirus infections…
(more)
▼ Human norovirus is a leading cause of acute gastroenteritis (AGE) worldwide and is estimated to be responsible for over 200,000 deaths each year. Norovirus infections are estimated to cost $60 billion in societal costs globally each year. Yet despite the substantial health and economic burden of norovirus, there is no vaccine or norovirus-specific antiviral approved for clinical use. Effective norovirus therapies are highly desired, particularly for the treatment of chronic norovirus infections, or for prophylaxis to limit outbreaks and protect high-risk groups, including the immunocompromised. Several direct-acting antivirals (DAAs) and host-targeted therapies have demonstrated inhibitory activity against noroviruses in vitro and in vivo, however none of these compounds have progressed through clinical trials. Therefore, this thesis aimed to discover new antivirals and expand the repertoire of compounds with the potential to be further developed for the treatment of norovirus infections. In the first study, RNA-sequencing was performed to provide insights into norovirus pathogenesis and to help identify new host targets that could be explored antiviral development. We found that norovirus infection dampens the transcriptional profile of several genes involved in MHC class I antigen presentation, likely for immune evasion. We also observed a significant reduction in TLR7 expression which could represent a mechanism to avoid recognition by the host. To explore this further, we screened several Toll-like receptor (TLR) agonists, currently in clinical trials for antiviral therapy, against norovirus and found that these compounds potently inhibit infection in vitro. Here we discovered a new target for norovirus antivirals. Lastly using in vitro antiviral assays against several caliciviruses, we discovered a new nucleoside analogue (NA), called NITD008, which represents the most potent NA described in the literature to date and a strong candidate for continued development. The new anti- norovirus compounds described in this thesis could be used as scaffolds for the generation of derivatives with improved drug properties or be used in combination with other compounds for improved efficacy. Overall, this thesis involved a multi-faceted approach to antiviral discovery which has increased the available compounds in the pre-clinical pipeline for norovirus therapy.
Advisors/Committee Members: White, Peter, Biotechnology & Biomolecular Sciences, Faculty of Science, UNSW, Edwards, Richard, Biotechnology & Biomolecular Sciences, Faculty of Science, UNSW.
Subjects/Keywords: Nucleoside analogue (NA); Norovirus; Antivirals
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APA ·
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MLA ·
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CSE |
Export
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APA (6th Edition):
Enosi Tuipulotu, D. (2018). Norovirus antiviral discovery: host-modulators and direct-acting antivirals. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/62681 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:58917/SOURCE02?view=true
Chicago Manual of Style (16th Edition):
Enosi Tuipulotu, Daniel. “Norovirus antiviral discovery: host-modulators and direct-acting antivirals.” 2018. Doctoral Dissertation, University of New South Wales. Accessed April 11, 2021.
http://handle.unsw.edu.au/1959.4/62681 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:58917/SOURCE02?view=true.
MLA Handbook (7th Edition):
Enosi Tuipulotu, Daniel. “Norovirus antiviral discovery: host-modulators and direct-acting antivirals.” 2018. Web. 11 Apr 2021.
Vancouver:
Enosi Tuipulotu D. Norovirus antiviral discovery: host-modulators and direct-acting antivirals. [Internet] [Doctoral dissertation]. University of New South Wales; 2018. [cited 2021 Apr 11].
Available from: http://handle.unsw.edu.au/1959.4/62681 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:58917/SOURCE02?view=true.
Council of Science Editors:
Enosi Tuipulotu D. Norovirus antiviral discovery: host-modulators and direct-acting antivirals. [Doctoral Dissertation]. University of New South Wales; 2018. Available from: http://handle.unsw.edu.au/1959.4/62681 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:58917/SOURCE02?view=true
15.
Ory, Kévin.
Activité et évaluation thérapeutique de dérivés furanosidiques sur le parasite Leishmania donovani : Activity and therapeutic evaluation of furanosidic derivates on Leishmania donovani parasite.
Degree: Docteur es, Biologie cellulaire et moléculaire, biochimie, 2019, Rennes 1
URL: http://www.theses.fr/2019REN1B001
► L’émergence de résistances de Leishmania vis-à-vis de certaines molécules ainsi que le coût élevé des traitements de la leishmaniose constituent une problématique dans les zones…
(more)
▼ L’émergence de résistances de Leishmania vis-à-vis de certaines molécules ainsi que le coût élevé des traitements de la leishmaniose constituent une problématique dans les zones d’endémie défavorisées. Le développement de nouvelles molécules efficaces et à bas coût est donc un enjeu majeur dans la prise en charge de cette maladie tropicale négligée. La voie métabolique du furanose présente chez Leishmania, mais complètement absente chez l’Homme, est une voie identifiée comme une cible potentielle. Chez Leishmania, cette voie est associée à la production de plusieurs facteurs de virulence, le LPG, et les GIPLs (espèce-dépendant). L’octyle de galactofuranose, analogue du substrat original a été développé et testé dans le cadre d’un modèle d’infection à Leishmania donovani. In vitro, une efficacité doseindépendante contre la forme amastigote a étédémontrée dans un modèle de macrophages humains. In vivo sur modèle murin infecté, l’oct-galf a montré des effets immunomodulateurs marqués, au-delà d’une activité anti-parasitaire plus modeste. Pour comprendre ces résultats, une nouvelle approche mécanistique a été envisagée. L’intelectin-1 (aussi appelé omentin-1) qui fait l’objet de nombreuses publications, est capable de lier les motifs furanosidiques. Les capacités de cette lectine à modifier les voies métaboliques énergétiques via l’AMPK corrèlent avec les résultats retrouvés dans nos modèles d’étude et suggèrent son implication dans l’effet anti-parasitaire observé.
The emergence of Leishmania resistance against various molecules as well as high cost of treatment of leishmaniasis represent a health problem in endemic developing countries. Development of new molecules, effective and at low-cost, is a key challenge in the management of this neglected disease. Furanose pathway is reported in Leishmania parasites, but is completely absent in Human. It was identified as a potential drug target. InLeishmania, this pathway is associated with production of virulence factors, LPG and GIPLs (species-dependant). Octyl-galactofuranose (oct-galf), an analogue of the original substrate, was developed and evaluate in the context of Leishmania donovani infection. In vitro, a dose-independent efficacy against amastigote form was demonstrated in a human macrophages model. Using a murine model, oct-galf showed strong immunomodulatory effects in vivo, while a moderate anti-parasitic effect. In order to better understand theseresults, a new mechanistic approach was considered. Intelectin-1 (also named omentin- 1) relating to a large number of publications, is able to bind furanosidic moieties. Abilities of this lectin to regulate energetic metabolic pathways via AMPK correlate with results we observed in our models and suggest its involvement in the anti-parasitic effects.
Advisors/Committee Members: Gangneux, Jean-Pierre (thesis director), Descoteaux, Albert (thesis director).
Subjects/Keywords: Leishmania donovani; Analogue furanosidique; Lpg; Leishmania donovani; Furanosidic analogue; Lpg
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Ory, K. (2019). Activité et évaluation thérapeutique de dérivés furanosidiques sur le parasite Leishmania donovani : Activity and therapeutic evaluation of furanosidic derivates on Leishmania donovani parasite. (Doctoral Dissertation). Rennes 1. Retrieved from http://www.theses.fr/2019REN1B001
Chicago Manual of Style (16th Edition):
Ory, Kévin. “Activité et évaluation thérapeutique de dérivés furanosidiques sur le parasite Leishmania donovani : Activity and therapeutic evaluation of furanosidic derivates on Leishmania donovani parasite.” 2019. Doctoral Dissertation, Rennes 1. Accessed April 11, 2021.
http://www.theses.fr/2019REN1B001.
MLA Handbook (7th Edition):
Ory, Kévin. “Activité et évaluation thérapeutique de dérivés furanosidiques sur le parasite Leishmania donovani : Activity and therapeutic evaluation of furanosidic derivates on Leishmania donovani parasite.” 2019. Web. 11 Apr 2021.
Vancouver:
Ory K. Activité et évaluation thérapeutique de dérivés furanosidiques sur le parasite Leishmania donovani : Activity and therapeutic evaluation of furanosidic derivates on Leishmania donovani parasite. [Internet] [Doctoral dissertation]. Rennes 1; 2019. [cited 2021 Apr 11].
Available from: http://www.theses.fr/2019REN1B001.
Council of Science Editors:
Ory K. Activité et évaluation thérapeutique de dérivés furanosidiques sur le parasite Leishmania donovani : Activity and therapeutic evaluation of furanosidic derivates on Leishmania donovani parasite. [Doctoral Dissertation]. Rennes 1; 2019. Available from: http://www.theses.fr/2019REN1B001
Oregon State University
16.
Maghari, Nima.
Architectural compensation techniques for analog inaccuracies in ΔΣ
analog-to-digital converters.
Degree: PhD, Electrical and Computer Engineering, 2010, Oregon State University
URL: http://hdl.handle.net/1957/18851
► Delta-sigma analog-to-digital converters (ADCs) are suitable for many applications due to several advantages such as relaxed anti-aliasing filter, high signal-to noise and distortion ratio (SNDR)…
(more)
▼ Delta-sigma
analog-to-digital converters (ADCs) are suitable for many applications due to several advantages such as relaxed anti-aliasing filter, high signal-to noise and distortion ratio (SNDR) and most important of all, reduced sensitivity to
analog imperfections.This thesis introduces several structures to overcome loop imperfections and stability issues in delta-sigma modulators. First, a new multi-loop delta-sigma modulator is proposed to combine the relaxed circuit requirements of single-loop modulators with the stability of traditional multi-loop modulators.
Measurement results of the prototype IC confirmed with opamps with loop gain of less than 30dB, SNDR of over 74dB can be achieved. Also proposed is a new single-loop modulator using a delay-free two-step quantizer enabling the input signals beyond the full-scale range to be processed by the loop. The fabricated prototype IC
achieves over 75dB SNDR by allowing signals up to +5dBFS input signals. Third, is a modified dual-slope ADC which achieves first-order quantization noise-shaping. Combined as the quantizer of a second-order delta-sigma loop, the fabricated prototype
IC achieves third-order noise shaping with 78dB peak SNDR.
Advisors/Committee Members: Moon, Un-Ku (advisor), Temes, Gabor (committee member).
Subjects/Keywords: Analog Ciruits; Analog-to-digital converters
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MLA ·
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CSE |
Export
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APA (6th Edition):
Maghari, N. (2010). Architectural compensation techniques for analog inaccuracies in ΔΣ
analog-to-digital converters. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/18851
Chicago Manual of Style (16th Edition):
Maghari, Nima. “Architectural compensation techniques for analog inaccuracies in ΔΣ
analog-to-digital converters.” 2010. Doctoral Dissertation, Oregon State University. Accessed April 11, 2021.
http://hdl.handle.net/1957/18851.
MLA Handbook (7th Edition):
Maghari, Nima. “Architectural compensation techniques for analog inaccuracies in ΔΣ
analog-to-digital converters.” 2010. Web. 11 Apr 2021.
Vancouver:
Maghari N. Architectural compensation techniques for analog inaccuracies in ΔΣ
analog-to-digital converters. [Internet] [Doctoral dissertation]. Oregon State University; 2010. [cited 2021 Apr 11].
Available from: http://hdl.handle.net/1957/18851.
Council of Science Editors:
Maghari N. Architectural compensation techniques for analog inaccuracies in ΔΣ
analog-to-digital converters. [Doctoral Dissertation]. Oregon State University; 2010. Available from: http://hdl.handle.net/1957/18851
Oregon State University
17.
Nishida, Yoshio.
Improved design techniques for analog and mixed circuits.
Degree: PhD, Electrical and Computer Engineering, 2008, Oregon State University
URL: http://hdl.handle.net/1957/7985
► Although the digital revolution can realize many of past analog components in the digital forms, our world is surrounded with analog signals such as voice,…
(more)
▼ Although the digital revolution can realize many of past
analog components in the digital forms, our world is surrounded with
analog signals such as voice, temperature, etc. The bridge between these two worlds is one of key performance limitations among overall systems and it includes
analog filters and data converters.
This thesis studies two design techniques with respect to the improvement of the performances of the bridge circuits; one is an implementation of the delta-sigma A/D converter with a new architecture and another is a proposed correlated double-sampling technique for continuous
analog filters. A circuit implementation for the new architecture converter is proposed and implemented in AKM 0.18µm CMOS technology. The test results show that the modulator achieves 72dB of SNDR from the 1.8 V supply voltage. A newly proposed correlated double sampling technique compensates the gain error of a high-Q Tow-Thomas filter which originates from the op-amp imperfections. The gain error is reduced to 0.6dB from 2.5dB with the correlated double sampling technique.
Advisors/Committee Members: Temes, Gabor C. (advisor), Magana, Mario (committee member).
Subjects/Keywords: analog; Analog-to-digital converters – Design
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APA (6th Edition):
Nishida, Y. (2008). Improved design techniques for analog and mixed circuits. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/7985
Chicago Manual of Style (16th Edition):
Nishida, Yoshio. “Improved design techniques for analog and mixed circuits.” 2008. Doctoral Dissertation, Oregon State University. Accessed April 11, 2021.
http://hdl.handle.net/1957/7985.
MLA Handbook (7th Edition):
Nishida, Yoshio. “Improved design techniques for analog and mixed circuits.” 2008. Web. 11 Apr 2021.
Vancouver:
Nishida Y. Improved design techniques for analog and mixed circuits. [Internet] [Doctoral dissertation]. Oregon State University; 2008. [cited 2021 Apr 11].
Available from: http://hdl.handle.net/1957/7985.
Council of Science Editors:
Nishida Y. Improved design techniques for analog and mixed circuits. [Doctoral Dissertation]. Oregon State University; 2008. Available from: http://hdl.handle.net/1957/7985
Addis Ababa University
18.
Abisa, Girma.
Configurable Analog Circuit Synthesis and Implementation Kit: PCB Based Approach
.
Degree: 2018, Addis Ababa University
URL: http://10.6.20.92/handle/123456789/20945
► The implementation of newly designed analog circuits in most cases is a merger of known analog circuit blocks. The testing of these analog circuits have…
(more)
▼ The implementation of newly designed
analog circuits in most cases is a merger of known
analog
circuit blocks. The testing of these
analog circuits have challenges like schematic to prototype part
discrepancy, being cumbersome, fragility and component value variation. Field Programmable
Analog Array (FPAA), could be considered
analog counterparts FPGA, have been used for the
design and development
analog circuits. FPAAs combine CAD tool with rapid prototyping of
analog circuits. FPAAs are monolithic programmable and generic
analog circuit building tools.
In this paper a configurable PCB based
analog circuit builder kit is to be designed and built as a
possible rugged alternative to FPAAs. The need for this alternative is put forward to utilize the
advantages of FPPAs in a more rugged and accessible
analog circuit building. This kit contains
real
analog circuit components with configurable interconnecting switches on a single board. The
building and validation testing of such a kit is performed in this research. It can handle more power
and larger components. It contains on board power supplies and component banks. This kit could
be instrumental in the education/training of
analog circuit design both in academia and industry.
Advisors/Committee Members: Getachew, Alemu (PhD) (advisor).
Subjects/Keywords: Analog Circuit;
PCB;
Analog Circuit Synthesis
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Export
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APA (6th Edition):
Abisa, G. (2018). Configurable Analog Circuit Synthesis and Implementation Kit: PCB Based Approach
. (Thesis). Addis Ababa University. Retrieved from http://10.6.20.92/handle/123456789/20945
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Abisa, Girma. “Configurable Analog Circuit Synthesis and Implementation Kit: PCB Based Approach
.” 2018. Thesis, Addis Ababa University. Accessed April 11, 2021.
http://10.6.20.92/handle/123456789/20945.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Abisa, Girma. “Configurable Analog Circuit Synthesis and Implementation Kit: PCB Based Approach
.” 2018. Web. 11 Apr 2021.
Vancouver:
Abisa G. Configurable Analog Circuit Synthesis and Implementation Kit: PCB Based Approach
. [Internet] [Thesis]. Addis Ababa University; 2018. [cited 2021 Apr 11].
Available from: http://10.6.20.92/handle/123456789/20945.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Abisa G. Configurable Analog Circuit Synthesis and Implementation Kit: PCB Based Approach
. [Thesis]. Addis Ababa University; 2018. Available from: http://10.6.20.92/handle/123456789/20945
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Texas A&M University
19.
Su, Eric Chen.
Analog FIR Filter Used for Range-Optimal Pulsed Radar Applications.
Degree: MS, Electrical Engineering, 2014, Texas A&M University
URL: http://hdl.handle.net/1969.1/153323
► Matched filter is one of the most critical block in radar applications. With different measured range and relative velocity of a target we will need…
(more)
▼ Matched filter is one of the most critical block in radar applications. With different measured range and relative velocity of a target we will need different bandwidth of the matched filter to maximize the radar signal to noise ratio (SNR). Conventional matched filter designs incorporate surface acoustic wave (SAW) filters. However, it is not inherently tunable and will need multiple SAW filters with to change the bandwidth resulting in costly solutions.
In this work, a novel method of implementing the matched filter with an
analog FIR filter is proposed. The FIR filter provides a linear phase response which is suitable for radar applications.
Analog FIR filters can be implemented in the discrete domain, requiring operational amplifiers, switches and capacitors. In this work, the FIR filter is implemented using a highly programmable operational transconductance amplifier with tunable transconductance gain.
The operational amplifiers designed for the filter uses a fully differential source degeneration topology to increase the linearity; also capacitive degeneration was placed to compensate its high frequency response. An active continuous-time common mode feedback (CMFB) circuit is also presented. This circuit presents a much smaller load capacitance to the output of the amplifier, yielding a higher frequency response.
To satisfy system specifications a 128-tap FIR system is implemented, which require over 128 amplifiers, 136 unity capacitors of 1pF each and 4760 switches. The functionality of the proposed architecture has been verified through schematic and behavior model simulations. In the simulation, the robustness of the FIR filter to process and temperature variation is also verified. The circuits were designed in the TowerJazz 180nm CMOS technology and fabricated on November 2013.
Advisors/Committee Members: Silva-Martinez, Jose (advisor), Jo, Javier (committee member), Hu, Jiang (committee member), Palermo, Sam (committee member).
Subjects/Keywords: Analog FIR Filter
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APA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Su, E. C. (2014). Analog FIR Filter Used for Range-Optimal Pulsed Radar Applications. (Masters Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/153323
Chicago Manual of Style (16th Edition):
Su, Eric Chen. “Analog FIR Filter Used for Range-Optimal Pulsed Radar Applications.” 2014. Masters Thesis, Texas A&M University. Accessed April 11, 2021.
http://hdl.handle.net/1969.1/153323.
MLA Handbook (7th Edition):
Su, Eric Chen. “Analog FIR Filter Used for Range-Optimal Pulsed Radar Applications.” 2014. Web. 11 Apr 2021.
Vancouver:
Su EC. Analog FIR Filter Used for Range-Optimal Pulsed Radar Applications. [Internet] [Masters thesis]. Texas A&M University; 2014. [cited 2021 Apr 11].
Available from: http://hdl.handle.net/1969.1/153323.
Council of Science Editors:
Su EC. Analog FIR Filter Used for Range-Optimal Pulsed Radar Applications. [Masters Thesis]. Texas A&M University; 2014. Available from: http://hdl.handle.net/1969.1/153323
University of Debrecen
20.
Csehi, Róbert.
Analog – Digital és Digital – Analog konverterek minőségi jellemzőinek mérése
.
Degree: DE – TEK – Természettudományi és Technológiai Kar – Fizikai Intézet, 2013, University of Debrecen
URL: http://hdl.handle.net/2437/167673
Egy kalibrátor vezérlőprogramjának elkészítése, A/D illetve D/A konvertert tesztelő mérőkör programjának elkészítése, a kapott mérési eredményekből a konverter hibáinak meghatározása, összegzése több mérés alapján.
Advisors/Committee Members: Harasztosi, Lajos (advisor).Subjects/Keywords: Analog;
Digital;
konverter
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Manager
APA (6th Edition):
Csehi, R. (2013). Analog – Digital és Digital – Analog konverterek minőségi jellemzőinek mérése
. (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/167673
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Csehi, Róbert. “Analog – Digital és Digital – Analog konverterek minőségi jellemzőinek mérése
.” 2013. Thesis, University of Debrecen. Accessed April 11, 2021.
http://hdl.handle.net/2437/167673.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Csehi, Róbert. “Analog – Digital és Digital – Analog konverterek minőségi jellemzőinek mérése
.” 2013. Web. 11 Apr 2021.
Vancouver:
Csehi R. Analog – Digital és Digital – Analog konverterek minőségi jellemzőinek mérése
. [Internet] [Thesis]. University of Debrecen; 2013. [cited 2021 Apr 11].
Available from: http://hdl.handle.net/2437/167673.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Csehi R. Analog – Digital és Digital – Analog konverterek minőségi jellemzőinek mérése
. [Thesis]. University of Debrecen; 2013. Available from: http://hdl.handle.net/2437/167673
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
California State University – Sacramento
21.
Cherupalli, Pranav Kumar.
Behavioral modeling of a regenerative comparator using Verilog-AMS.
Degree: MS, Electrical and Electronic Engineering, 2011, California State University – Sacramento
URL: http://hdl.handle.net/10211.9/1094
► Comparators are widely used in mixed-signal systems. They are an essential building block of any analog-to-digital converter architecture. Regenerative comparators are typically used in high-speed…
(more)
▼ Comparators are widely used in mixed-signal systems. They are an essential building block of any
analog-to-digital converter architecture. Regenerative comparators are typically used in high-speed
analog-to-digital convertor designs. This particular architecture has two main characteristics that make it differentiable from the other architectures. First is the positive feedback during the regenerative phase to achieve high gain and the second is the cancellation of the memory of previous comparison results during the reset phase.
A behavioral model of any circuitry block is always helpful, before creating the actual design, to understand the tradeoffs during system design. Verilog-AMS provides an extended capability to model any
analog or digital block, so as to seamlessly integrate the behavioral block into the actual design consisting of a combination of
analog and digital blocks. A mapping between the
analog and digital domains enhances the (re)usability of designs for mixed-signal blocks. Since Verilog-AMS actively supports the mixed-signal approach, the interchange of digital and
analog blocks is straightforward. This work will result in a behavioral model for a regenerative comparator written in Verilog-AMS.
The project presents the behavioral model of a regenerative comparator written in Verilog-AMS. The model is simulated using the time-windowing function to find the sensitivity of the comparator to pre- and post-clock inputs. The key specifications described in [3] by Thomas Matthews will be used to compare Verilog-AMS behavioral model circuit simulation results with analytical results.
Advisors/Committee Members: Matthews, Thomas W..
Subjects/Keywords: Analog design modelling
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APA (6th Edition):
Cherupalli, P. K. (2011). Behavioral modeling of a regenerative comparator using Verilog-AMS. (Masters Thesis). California State University – Sacramento. Retrieved from http://hdl.handle.net/10211.9/1094
Chicago Manual of Style (16th Edition):
Cherupalli, Pranav Kumar. “Behavioral modeling of a regenerative comparator using Verilog-AMS.” 2011. Masters Thesis, California State University – Sacramento. Accessed April 11, 2021.
http://hdl.handle.net/10211.9/1094.
MLA Handbook (7th Edition):
Cherupalli, Pranav Kumar. “Behavioral modeling of a regenerative comparator using Verilog-AMS.” 2011. Web. 11 Apr 2021.
Vancouver:
Cherupalli PK. Behavioral modeling of a regenerative comparator using Verilog-AMS. [Internet] [Masters thesis]. California State University – Sacramento; 2011. [cited 2021 Apr 11].
Available from: http://hdl.handle.net/10211.9/1094.
Council of Science Editors:
Cherupalli PK. Behavioral modeling of a regenerative comparator using Verilog-AMS. [Masters Thesis]. California State University – Sacramento; 2011. Available from: http://hdl.handle.net/10211.9/1094
Wake Forest University
22.
Dudley, Richard Allen.
Bose-Einstein Condensate Analog Black Holes.
Degree: 2020, Wake Forest University
URL: http://hdl.handle.net/10339/96943
Investigations of the properties of Bose Einstein condensate analog black holes that are related to Hawking radiation are discussed.
Subjects/Keywords: Analog Black holes
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APA (6th Edition):
Dudley, R. A. (2020). Bose-Einstein Condensate Analog Black Holes. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/96943
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Dudley, Richard Allen. “Bose-Einstein Condensate Analog Black Holes.” 2020. Thesis, Wake Forest University. Accessed April 11, 2021.
http://hdl.handle.net/10339/96943.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Dudley, Richard Allen. “Bose-Einstein Condensate Analog Black Holes.” 2020. Web. 11 Apr 2021.
Vancouver:
Dudley RA. Bose-Einstein Condensate Analog Black Holes. [Internet] [Thesis]. Wake Forest University; 2020. [cited 2021 Apr 11].
Available from: http://hdl.handle.net/10339/96943.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Dudley RA. Bose-Einstein Condensate Analog Black Holes. [Thesis]. Wake Forest University; 2020. Available from: http://hdl.handle.net/10339/96943
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Université de Grenoble
23.
Chardon, Jérémy.
Intérêts de la méthode des analogues pour la génération de scénarios de précipitations à l'échelle de la France métropolitaine : Cohérence spatiale et adaptabilité du lien d'échelle : Interests of the analog method for the generation of precipitation scenarios for the French territory : Spatial consistency and adaptability of the scale relation.
Degree: Docteur es, Océan, atmosphère, hydrologie, 2014, Université de Grenoble
URL: http://www.theses.fr/2014GRENU044
► Les scénarios hydrologiques requis pour les études d'impacts hydrologiques nécessitent de disposer de scénarios météorologiques non biaisés et qui soient de surcroît adaptés aux échelles…
(more)
▼ Les scénarios hydrologiques requis pour les études d'impacts hydrologiques nécessitent de disposer de scénarios météorologiques non biaisés et qui soient de surcroît adaptés aux échelles spatiales et temporelles des hydro-systèmes considérés. Les scénarios météorologiques obtenus en sortie brute des modèles de climat et/ou des modèles de prévision numérique du temps sont de ce fait non appropriées. Les sorties de ces modèles sont par suite souvent adaptées à l'aide de Méthodes de Descente d'Echelle Statistique (MDES). Depuis les années 2000, les MDES ont beaucoup été utilisées pour la génération de scénarios météorologiques en un site. En revanche, la génération de scénarios spatiaux couvrant de larges territoires est une tâche plus difficile, en particulier lorsque l'on souhaite respecter la cohérence spatiale des précipitations à prédire. Parmi les MDES usuelles, les approches basées sur la recherche de situations analogues passées permettent de satisfaire cette contrainte. Dans cette thèse, nous évaluons la capacité d'un Modèle Analog (MA) – où l'analogie porte sur les géopotentiels 1 000 et 500 hPa – pour la génération de scénarios de précipitation spatialement cohérents pour le territoire Français métropolitain. Dans un premier temps, la transposition spatiale du modèle MA est évaluée : le modèle s'avère utilisable pour la génération de scénarios spatiaux cohérents sur des territoires couvrant plusieurs dizaines de milliers de kilomètres carrés dès lors qu'aucune barrière climatique n'est rencontrée. Dans un second temps, nous évaluons la sensibilité des performances de prédiction à l'agrégation spatiale de la variable à prédire. L'augmentation de performance avec l'agrégation s'explique alors par la diminution de la variabilité du prédictand, pour autant que les variables de grande échelle considérées soient de bons prédicteurs pour la région considérée. Dans une dernière étude, nous explorons la possibilité d'améliorer la performance locale du modèle analogue par l'ajout de prédicteurs locaux. Le modèle combiné qui en résulte permet d'accroître sensiblement les performances de prédiction par l'adaptation du lien d'échelle sur la base d'un jeu de prédicteurs additionnels. Il apparaît de plus que la pertinence de ces prédicteurs dépend de la situation de grande échelle rencontrée ainsi que de la région considérée.
Hydrological scenarios required for the impact studies need to have unbiased meteorological scenarios adapted to the space and time scales of the considered hydro-systems. Hence, meteorological scenarios obtained from global climate models and/or numerical weather prediction models are not really appropriated. Outputs of these models have to be post-processed, which is often carried out thanks to Statistical Downscaling Methods (SDMs). Since the 2000's, SDMs are widely used for the generation of scenarios at a single site. The generation of relevant precipitation fields over large regions or hydro-systems is conversely not straightforward, in particular when the spatial consistency has to be…
Advisors/Committee Members: Favre Pugin, Anne-Catherine (thesis director), Hingray, Benoît (thesis director).
Subjects/Keywords: Analogue; Descente d'Echelle Statistique; Précipitation; Prédiction; Cohérence spatiale; GLM; France; Analog; Statistical Downscaling; Precipitation; Prediction; Spatial consistency; GLM; France; 550
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APA ·
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Export
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APA (6th Edition):
Chardon, J. (2014). Intérêts de la méthode des analogues pour la génération de scénarios de précipitations à l'échelle de la France métropolitaine : Cohérence spatiale et adaptabilité du lien d'échelle : Interests of the analog method for the generation of precipitation scenarios for the French territory : Spatial consistency and adaptability of the scale relation. (Doctoral Dissertation). Université de Grenoble. Retrieved from http://www.theses.fr/2014GRENU044
Chicago Manual of Style (16th Edition):
Chardon, Jérémy. “Intérêts de la méthode des analogues pour la génération de scénarios de précipitations à l'échelle de la France métropolitaine : Cohérence spatiale et adaptabilité du lien d'échelle : Interests of the analog method for the generation of precipitation scenarios for the French territory : Spatial consistency and adaptability of the scale relation.” 2014. Doctoral Dissertation, Université de Grenoble. Accessed April 11, 2021.
http://www.theses.fr/2014GRENU044.
MLA Handbook (7th Edition):
Chardon, Jérémy. “Intérêts de la méthode des analogues pour la génération de scénarios de précipitations à l'échelle de la France métropolitaine : Cohérence spatiale et adaptabilité du lien d'échelle : Interests of the analog method for the generation of precipitation scenarios for the French territory : Spatial consistency and adaptability of the scale relation.” 2014. Web. 11 Apr 2021.
Vancouver:
Chardon J. Intérêts de la méthode des analogues pour la génération de scénarios de précipitations à l'échelle de la France métropolitaine : Cohérence spatiale et adaptabilité du lien d'échelle : Interests of the analog method for the generation of precipitation scenarios for the French territory : Spatial consistency and adaptability of the scale relation. [Internet] [Doctoral dissertation]. Université de Grenoble; 2014. [cited 2021 Apr 11].
Available from: http://www.theses.fr/2014GRENU044.
Council of Science Editors:
Chardon J. Intérêts de la méthode des analogues pour la génération de scénarios de précipitations à l'échelle de la France métropolitaine : Cohérence spatiale et adaptabilité du lien d'échelle : Interests of the analog method for the generation of precipitation scenarios for the French territory : Spatial consistency and adaptability of the scale relation. [Doctoral Dissertation]. Université de Grenoble; 2014. Available from: http://www.theses.fr/2014GRENU044
Jönköping University
24.
Schill, Johan.
Yngre elevers svårigheter för den analoga klockan : En intervjustudie i årskurs 2-3.
Degree: Education and Communication, 2020, Jönköping University
URL: http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-48954
► För att på ett fördjupat sätt förstå innebörden i olika svårigheter som elever i årskurs 2–3 kan ha gällande tidsavläsning från den analoga klockan…
(more)
▼ För att på ett fördjupat sätt förstå innebörden i olika svårigheter som elever i årskurs 2–3 kan ha gällande tidsavläsning från den analoga klockan är detta en intervjustudie med sju elever som besvarar frågeställningen: vad urskiljer/urskiljer inte eleverna när de löser olika uppgifter som handlar om att avläsa tid från den analoga klockan? Som teoretisk utgångspunkt används variationsteorin då dess olika begrepp är centrala för att förstå hur en annan person uppfattar ett specifikt ämnesinnehåll. I resultatet redovisas de olika aspekter av innehållet kring tidsavläsning från den analoga klockan som eleverna urskilt eller inte urskilt som i sin tur leder till att olika svårigheter identifieras. Vidare diskuteras studiens styrkor och svagheter i relation till metodval samt hur resultatet förhåller sig till tidigare forskning, styrdokument och yrkesverksamheten. Sammanfattningsvis framgår det ur resultatet att en övergripande svårighet har att göra med att eleverna inte urskilt att klockan är uppbyggd på 60 minuter och till stor del förlitar sig på minnesassociationer vid avläsning av minutvisaren.
This is an interview study with seven students. To understand the deeper meaning of various difficulties that students in grades 2–3 may have regarding time telling on the analogue clock this study answers the question: what does the students discern/not discern when they solve different tasks involving time telling on the analogue clock? As a theoretical framework, the variation theory is used as its various concepts are central to understand how another person perceives a specific curriculum content. The result shows the different aspects of the content, regarding time telling on the analogue clock, that the students did discern or did not discern, which in turn leads to the identification of various difficulties. Furthermore, a discussion is being held regarding the strengths and weaknesses in relation to the chosen method as well as how the result relates to previous research, curriculum documents and the profession of education. In summary, it is clear from the result that an overall difficulty has to do with the students not discerning that the clock is built up in 60 minutes and largely relies on memory associations when reading the minute hand.
Subjects/Keywords: difficulty; time telling; analogue clock; mathematics education; variation theory; svårighet; avläsning; analog klocka; matematikundervisning; variationsteori; Geometry; Geometri
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APA (6th Edition):
Schill, J. (2020). Yngre elevers svårigheter för den analoga klockan : En intervjustudie i årskurs 2-3. (Thesis). Jönköping University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-48954
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Schill, Johan. “Yngre elevers svårigheter för den analoga klockan : En intervjustudie i årskurs 2-3.” 2020. Thesis, Jönköping University. Accessed April 11, 2021.
http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-48954.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Schill, Johan. “Yngre elevers svårigheter för den analoga klockan : En intervjustudie i årskurs 2-3.” 2020. Web. 11 Apr 2021.
Vancouver:
Schill J. Yngre elevers svårigheter för den analoga klockan : En intervjustudie i årskurs 2-3. [Internet] [Thesis]. Jönköping University; 2020. [cited 2021 Apr 11].
Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-48954.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Schill J. Yngre elevers svårigheter för den analoga klockan : En intervjustudie i årskurs 2-3. [Thesis]. Jönköping University; 2020. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-48954
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
25.
Zbili, Mickael.
Plasticités synaptiques à court et long terme via la modulation de la forme du potentiel d'action axonal dans les réseaux corticaux : Short and long term synaptic plasticities via action potential shape modulation in cortical networks.
Degree: Docteur es, Neurosciences, 2016, Aix Marseille Université
URL: http://www.theses.fr/2016AIXM5039
► La transmission synaptique dans les corticaux est généralement décrite comme un phénomène de « tout ou rien » ou digital. Un Potentiel d'Action (PA) est…
(more)
▼ La transmission synaptique dans les corticaux est généralement décrite comme un phénomène de « tout ou rien » ou digital. Un Potentiel d'Action (PA) est émis dans la cellule présynaptique, provoquant le relargage de neurotransmetteurs au niveau du bouton présynaptique et, en conséquence, une dépolarisation transitoire de la cellule postsynaptique (Potentiel Post-Synaptique Excitateur ou PPSE). Cependant, de nombreuses études ont démontrées que la forme du PA présynaptique dépend de l'activité sous liminaire précédant son émission. En effet, si la cellule présynaptique est dépolarisée durant 5 à 10 s avant l'émission du PA, ce dernier s'élargit, ce qui provoque une augmentation du relargage de neurotransmetteurs et de l'amplitude du PPSE. Ainsi, la transmission synaptique dépend d'un phénomène digital, le PA, dont la forme est modulée analogiquement. On parle de transmission Analogique-Digitale. L'élargissement du PA et l'augmentation de la transmission synaptique suite à une longue dépolarisation de la transmission synaptique est nommée Facilitation Analogique-Digital due à la Dépolarisation (FADD). Durant cette thèse, nous nous sommes posé 3 questions principales. Quel est le mécanisme biophysique de la FADD ? Existe-il des Facilitations Analogique Digitale dépendante de modulation de l'amplitude du PA et non de sa largeur ? Les modulations de la forme du PA sont-elles toutes à court terme (de la milliseconde à la seconde) ou existe-t-il des modulations de la forme du PA à long terme (plusieurs jours) ? Pour répondre à la première question, nous avons enregistré des paires de neurones CA3 de l'hippocampe et avons dépolarisé la cellule présynaptique durant 10 s avant l'émission du PA. Nous avons observé une FADD de 30 % qui était supprimée par le blocage pharmacologique des canaux potassiques axonaux Kv1. Ces canaux sont responsables de la phase de repolarisation du PA et ont la propriété de s'inactiver durant de longues dépolarisations. Nous en avons conclu qu'entre les neurones CA3, la FADD était due à l'inactivation des canaux Kv1 pendant la dépolarisation précédant le PA, ce qui provoque un ralentissement de la phase de repolarisation du PA et ainsi un élargissment du PA. Afin de répondre à la seconde question, nous avons enregistré des paires de neurones CA3 dans l'hippocampe. Nous avons observé qu'une courte hyperpolarisation (50 ms) du neurone présynaptique avant l'émission du potentiel d'action provoquait une augmentation de l'amplitude du PA entrainant un accroissement du relargage de neurotransmetteur et de la taille du PPSE. Nous avons nommé ce phénomène FADH pour Facilitation Analogique-Digitale induite par Hyperpolarisation. La FADH est due à récupération de l'inactivation de canaux sodiques responsables de l'amplitude du PA quand le neurone présynaptique est hyperpolarisé, ce qui augmente leur disponibilité. Enfin, pour répondre à la troisième question, nous avons bloqué la transmission synaptique entre les neurones CA3 durant 3 jours. Cela a entrainé une augmentation compensatoire de la transmission…
Advisors/Committee Members: Debanne, Dominique (thesis director).
Subjects/Keywords: Plasticité; Homéostasie; Axone; Courant sodium; Facilitation analogue digitale; Courant ID; Plasticity; Homeostasy; Axon; Sodium current; Analog digital facilitation; ID current
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APA ·
Chicago ·
MLA ·
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Export
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APA (6th Edition):
Zbili, M. (2016). Plasticités synaptiques à court et long terme via la modulation de la forme du potentiel d'action axonal dans les réseaux corticaux : Short and long term synaptic plasticities via action potential shape modulation in cortical networks. (Doctoral Dissertation). Aix Marseille Université. Retrieved from http://www.theses.fr/2016AIXM5039
Chicago Manual of Style (16th Edition):
Zbili, Mickael. “Plasticités synaptiques à court et long terme via la modulation de la forme du potentiel d'action axonal dans les réseaux corticaux : Short and long term synaptic plasticities via action potential shape modulation in cortical networks.” 2016. Doctoral Dissertation, Aix Marseille Université. Accessed April 11, 2021.
http://www.theses.fr/2016AIXM5039.
MLA Handbook (7th Edition):
Zbili, Mickael. “Plasticités synaptiques à court et long terme via la modulation de la forme du potentiel d'action axonal dans les réseaux corticaux : Short and long term synaptic plasticities via action potential shape modulation in cortical networks.” 2016. Web. 11 Apr 2021.
Vancouver:
Zbili M. Plasticités synaptiques à court et long terme via la modulation de la forme du potentiel d'action axonal dans les réseaux corticaux : Short and long term synaptic plasticities via action potential shape modulation in cortical networks. [Internet] [Doctoral dissertation]. Aix Marseille Université 2016. [cited 2021 Apr 11].
Available from: http://www.theses.fr/2016AIXM5039.
Council of Science Editors:
Zbili M. Plasticités synaptiques à court et long terme via la modulation de la forme du potentiel d'action axonal dans les réseaux corticaux : Short and long term synaptic plasticities via action potential shape modulation in cortical networks. [Doctoral Dissertation]. Aix Marseille Université 2016. Available from: http://www.theses.fr/2016AIXM5039
Université Paris-Sud – Paris XI
26.
Coutant, Antonin.
On the phenomenology of quantum gravity : stability properties of Hawking radiation in the presence of ultraviolet violation of local Lorentz invariance : phénoménologie de la gravité quantique : Propriété de stabilité de la radiation d'Hawking en présence de violation de l'invariance local de Lorentz.
Degree: Docteur es, Physique, 2012, Université Paris-Sud – Paris XI
URL: http://www.theses.fr/2012PA112213
► Dans cette thèse, nous étudions plusieurs aspects de la radiation de Hawking en présence de violations de l'invariance locale de Lorentz. Ces violations sont introduites…
(more)
▼ Dans cette thèse, nous étudions plusieurs aspects de la radiation de Hawking en présence de violations de l'invariance locale de Lorentz. Ces violations sont introduites par une modification de la relation de dispersion, devenant non-linéaire aux courtes longueurs d’onde. Les principales motivations de ces travaux ont une double origine. Il y a d’une part le développement en matière condensée de trous noirs analogues, ou l’écoulement d’un fluide est perçu comme une métrique d’espace-temps pour les ondes de perturbations et ou la radiation de Hawking pourrait être détectée expérimentalement. D’autre part, il se pourrait que des effets de gravité quantique puissent être modélisés par une modification de la relation de dispersion. En premier lieu, nous avons obtenu des caractérisations précises des conditions nécessaires au maintien de l’effet Hawking en présence de violation de l’invariance de Lorentz. De plus, nous avons étudié l’apparition d’une onde macroscopique de fréquence nulle, dans des écoulements de type trous blancs et également pour des champs massifs. Une autre partie de ce travail a consisté à analyser une instabilité engendrée par les effets dispersifs, ou la radiation de Hawking est auto-amplifiée, générant ainsi un flux sortant exponentiellement croissant dans le temps.
In this thesis, we study several features of Hawking radiation in the presence of ultraviolet Lorentz violations. These violations are implemented by a modified dispersion relation that becomes nonlinear at short wavelengths. The motivations of this work arise on the one hand from the developing field of analog gravity, where we aim at measuring the Hawking effect in fluid flows that mimic black hole space-times, and on the other hand from the possibility that quantum gravity effects might be approximately modeled by a modified dispersion relation. We develop several studies on various aspects of the prob- lem. First we obtain precise characterizations about the deviations from the Hawking result of black hole radiation, which are induced by dispersion. Second, we study the emergence, both in white hole flows or for massive fields, of a macroscopic standing wave, spontaneously produced from the Hawking effect, and known as ‘undulation’. Third, we describe in detail an instability named black hole laser, which arises in the presence of two horizons, where Hawking radiation is self-amplified and induces an exponentially growing in time emitted flux.
Advisors/Committee Members: Parentani, Renaud (thesis director).
Subjects/Keywords: Radiation de Hawking; Gravit´e analogue; Violation de Lorentz; Instabilit´es; Undulations; Hawking radiation; Analog gravity; Lorentz violation; Instabilities; Undulations
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Chicago ·
MLA ·
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CSE |
Export
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APA (6th Edition):
Coutant, A. (2012). On the phenomenology of quantum gravity : stability properties of Hawking radiation in the presence of ultraviolet violation of local Lorentz invariance : phénoménologie de la gravité quantique : Propriété de stabilité de la radiation d'Hawking en présence de violation de l'invariance local de Lorentz. (Doctoral Dissertation). Université Paris-Sud – Paris XI. Retrieved from http://www.theses.fr/2012PA112213
Chicago Manual of Style (16th Edition):
Coutant, Antonin. “On the phenomenology of quantum gravity : stability properties of Hawking radiation in the presence of ultraviolet violation of local Lorentz invariance : phénoménologie de la gravité quantique : Propriété de stabilité de la radiation d'Hawking en présence de violation de l'invariance local de Lorentz.” 2012. Doctoral Dissertation, Université Paris-Sud – Paris XI. Accessed April 11, 2021.
http://www.theses.fr/2012PA112213.
MLA Handbook (7th Edition):
Coutant, Antonin. “On the phenomenology of quantum gravity : stability properties of Hawking radiation in the presence of ultraviolet violation of local Lorentz invariance : phénoménologie de la gravité quantique : Propriété de stabilité de la radiation d'Hawking en présence de violation de l'invariance local de Lorentz.” 2012. Web. 11 Apr 2021.
Vancouver:
Coutant A. On the phenomenology of quantum gravity : stability properties of Hawking radiation in the presence of ultraviolet violation of local Lorentz invariance : phénoménologie de la gravité quantique : Propriété de stabilité de la radiation d'Hawking en présence de violation de l'invariance local de Lorentz. [Internet] [Doctoral dissertation]. Université Paris-Sud – Paris XI; 2012. [cited 2021 Apr 11].
Available from: http://www.theses.fr/2012PA112213.
Council of Science Editors:
Coutant A. On the phenomenology of quantum gravity : stability properties of Hawking radiation in the presence of ultraviolet violation of local Lorentz invariance : phénoménologie de la gravité quantique : Propriété de stabilité de la radiation d'Hawking en présence de violation de l'invariance local de Lorentz. [Doctoral Dissertation]. Université Paris-Sud – Paris XI; 2012. Available from: http://www.theses.fr/2012PA112213
Iowa State University
27.
Liu, Zhiqiang.
Design and verification approaches for reliability and functional safety of analog integrated circuits.
Degree: 2018, Iowa State University
URL: https://lib.dr.iastate.edu/etd/17246
► New breakthroughs in semiconductor design have enabled a rapid integration of semiconductor chips into systems that affect all aspects of the society. Examples of emerging…
(more)
▼ New breakthroughs in semiconductor design have enabled a rapid integration of semiconductor chips into systems that affect all aspects of the society. Examples of emerging systems include spacecraft, Internet of Things (IoT), intelligent automotive, and bio-implantable devices. Many of these systems are mission-critical or safety-critical, meaning that failure or malfunction may lead to severe economical losses, environmental damages or risks to human lives. In addition to performances improvement, the reliability and functional safety of the underlying integrated circuit (IC) have attracted more and more attention and have posed grand challenges for semiconductor industries. This dissertation introduces an approach for high performance voltage reference design and investigates two subjects that improve the reliability and functional safety of analog circuits.
The first part of this dissertation studies design strategies of a low temperature-coefficient voltage reference generator, which is a fundamental building block and determines the maximum achievable performance of almost all analog/mixed-signal systems. The proposed method is targeted at extracting a physical quantity of the silicon bandgap, and has the potential of designing a voltage reference that has qualitatively better temperature dependence. An implementation of the proposed approach in GlobalFoundries 130nm process shows that the design can achieve temperature coefficients as low as 0.7ppm/°C over a temperature range of -40°C to 125°C over all process corners.
The second part of this dissertation focuses on multi-states verification of analog circuits. The multiple DC equilibrium points or multi-states problem traces back to IC design. It is a well-known problem in many basic self-stabilized analog circuits because of the existence of positive feedback loops (PFLs). This work proposes systematic and automatic approaches for locating all PFLs to identify circuits vulnerable to undesired equilibrium states and methods for automatically identifying break-points to break all PFLs in the vulnerable circuits. The proposed methods make it possible to efficiently identify a circuit’s vulnerability to undesired operating points by considering circuit topology only, without the need for finding all possible solutions to a set of simultaneous nonlinear equations which is an open problem with no solution. Moreover, the automatic break-points identification enables easy use of homotopy analysis to guarantee absence of undesired states.
The third part of this dissertation focuses on fault coverage simulation of analog circuits. This work describe two methods, one is to reduce the fault coverage estimation time and the other is to improve the fault coverage for analog circuits. The first method incorporates graph theory and sensitivity analysis and leads to dramatic reduction in fault coverage simulation time by 10’s of times for a moderately sized analog circuit. The second method discusses a systematic test-points selection technique to improve the analog fault…
Subjects/Keywords: Analog Design; Analog Integrated Circuits; Analog Verification; Electrical and Electronics
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APA (6th Edition):
Liu, Z. (2018). Design and verification approaches for reliability and functional safety of analog integrated circuits. (Thesis). Iowa State University. Retrieved from https://lib.dr.iastate.edu/etd/17246
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Liu, Zhiqiang. “Design and verification approaches for reliability and functional safety of analog integrated circuits.” 2018. Thesis, Iowa State University. Accessed April 11, 2021.
https://lib.dr.iastate.edu/etd/17246.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Liu, Zhiqiang. “Design and verification approaches for reliability and functional safety of analog integrated circuits.” 2018. Web. 11 Apr 2021.
Vancouver:
Liu Z. Design and verification approaches for reliability and functional safety of analog integrated circuits. [Internet] [Thesis]. Iowa State University; 2018. [cited 2021 Apr 11].
Available from: https://lib.dr.iastate.edu/etd/17246.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Liu Z. Design and verification approaches for reliability and functional safety of analog integrated circuits. [Thesis]. Iowa State University; 2018. Available from: https://lib.dr.iastate.edu/etd/17246
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Pretoria
28.
Reddy, Reeshen.
Spurious free
dynamic range enhancement of high-speed integrated digital to
analogue converters using bicmos technology.
Degree: MEng, Electrical, Electronic and
Computer Engineering, 2015, University of Pretoria
URL: http://hdl.handle.net/2263/48947
► High-speed digital to analogue converters (DAC), which are optimised for large bandwidth signal synthesis applications, are a fundamental building block and enabling technology in industrial…
(more)
▼ High-speed digital to analogue converters (DAC), which
are optimised for large bandwidth signal synthesis applications,
are a fundamental building block and enabling technology in
industrial instrumentation, military, communication and medical
applications. The spurious free dynamic range (SFDR) is a key
specification of high-speed DACs, as unwanted spurious signals
generated by the DAC degrades the performance and effectiveness of
wideband systems. The focus of this work is to enhance the SFDR
performance of high-speed DACs.
As bandwidth requirements
increase, meeting the desired SFDR performance is further
complicated by the increase in dynamic non-linearity. The most
widely used architecture in high-speed applications is the
current-steering DAC fabricated on CMOS technology. The current
source finite output impedance, switch distortion and clock
feedthrough are the greatest contributors to dynamic non-linearity
and are difficult to improve with the use of MOS devices alone.
This research proposes the use of BiCMOS technology that offers
high performance, using heterojunction bipolar transistors (HBT)
that, when combined with MOS devices, are able to improve on the
linearity of the current-steering DAC and hence improve the SFDR.
A design methodology is introduced based on BiCMOS fabrication
technology to improve SFDR performance and places emphasis on the
constraints of modern fabrication processes. A six-bit
current-steering application-specific integrated circuit DAC is
designed based on the proposed design methodology, which optimises
the SFDR performance of high-speed binary weighted architectures by
lowering current switch distortion and reducing the clock
feedthrough effect to verify the hypothesis experimentally.
A
novel current source cell is implemented that comprises HBT current
switches, negative channel metal-oxide semiconductor (NMOS) cascode
and NMOS current source to overcome distortion by specifically
enhancing the SFDR for high-speed DACs. A switch driver and
low-voltage differential signalling receiver to achieve high-speed
DAC performance and their influence on the SFDR performance are
designed and discussed.
The DAC is implemented using the
International Business Machines Corporation (IBM) 8HP silicon
germanium (SiGe) BiCMOS 130 nm technology. The DAC achieves a
better than 21.96 dBc SFDR across the Nyquist band for a sampling
rate of 500 MS/s with a core size of 0.1 mm2 and dissipates just 4
mW compared to other BiCMOS DACs that achieve similar SFDR
performance with higher output voltages, resulting in much larger
power dissipation.
Advisors/Committee Members: Sinha, Saurabh (advisor).
Subjects/Keywords: Microelectronic;
Digital-analogue conversion; BiCMOS
integrated circuits; Dynamic
range;
Analogue-digital integrated circuits; Mixed
analogue digital integrated circuits; UCTD
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APA ·
Chicago ·
MLA ·
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Export
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Manager
APA (6th Edition):
Reddy, R. (2015). Spurious free
dynamic range enhancement of high-speed integrated digital to
analogue converters using bicmos technology. (Masters Thesis). University of Pretoria. Retrieved from http://hdl.handle.net/2263/48947
Chicago Manual of Style (16th Edition):
Reddy, Reeshen. “Spurious free
dynamic range enhancement of high-speed integrated digital to
analogue converters using bicmos technology.” 2015. Masters Thesis, University of Pretoria. Accessed April 11, 2021.
http://hdl.handle.net/2263/48947.
MLA Handbook (7th Edition):
Reddy, Reeshen. “Spurious free
dynamic range enhancement of high-speed integrated digital to
analogue converters using bicmos technology.” 2015. Web. 11 Apr 2021.
Vancouver:
Reddy R. Spurious free
dynamic range enhancement of high-speed integrated digital to
analogue converters using bicmos technology. [Internet] [Masters thesis]. University of Pretoria; 2015. [cited 2021 Apr 11].
Available from: http://hdl.handle.net/2263/48947.
Council of Science Editors:
Reddy R. Spurious free
dynamic range enhancement of high-speed integrated digital to
analogue converters using bicmos technology. [Masters Thesis]. University of Pretoria; 2015. Available from: http://hdl.handle.net/2263/48947
Universiteit Utrecht
29.
Weekenstroo, M.
The controlling parameters of the structural style in the Oslo-Asker section: A field and analogue modeling study.
Degree: 2016, Universiteit Utrecht
URL: http://dspace.library.uu.nl:8080/handle/1874/325647
► The foreland basin situated in the Oslo area is comprised of Paleozoic sediments that are deformed during the Caledonian orogeny. A structural model for the…
(more)
▼ The foreland basin situated in the Oslo area is comprised of Paleozoic sediments that are deformed during the Caledonian orogeny. A structural model for the development of this basin is proposed by Bruton et al. (2010) but it lacks detailed structural field data to support the model. Building further on this model we performed a kinematic field study and analogue modeling to increase the understanding of the Caledonian history of the Oslo area. An 8 km N-S profile has been constructed in the Slemmestad area which showed a transition in structural style from dominant foreland directed thrusting in the south to hinterland directed thrusting in the middle and folding in the north. The entire Slemmestad are shows a dominant top to the SE transport direction with a 60/10 fold axis. The main controlling mechanism for the difference in structural style is the difference in lithology with the ratio of limestone to shale becoming higher from south to north. Interpreting the field data from the Slemmestad area in terms of deformation style shows a good match with the model from Bruton et al. (2010). The analogue models show deformation structures that are also found in the field and are therefore a good addition to strengthen the support of the model from (Bruton et al. 2010).
Advisors/Committee Members: Sokoutis, Prof. Dr. D., Gabrielsen, Prof. Dr. R.H..
Subjects/Keywords: Analogue modelling; structural style; Oslo-Asker
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APA ·
Chicago ·
MLA ·
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CSE |
Export
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Manager
APA (6th Edition):
Weekenstroo, M. (2016). The controlling parameters of the structural style in the Oslo-Asker section: A field and analogue modeling study. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/325647
Chicago Manual of Style (16th Edition):
Weekenstroo, M. “The controlling parameters of the structural style in the Oslo-Asker section: A field and analogue modeling study.” 2016. Masters Thesis, Universiteit Utrecht. Accessed April 11, 2021.
http://dspace.library.uu.nl:8080/handle/1874/325647.
MLA Handbook (7th Edition):
Weekenstroo, M. “The controlling parameters of the structural style in the Oslo-Asker section: A field and analogue modeling study.” 2016. Web. 11 Apr 2021.
Vancouver:
Weekenstroo M. The controlling parameters of the structural style in the Oslo-Asker section: A field and analogue modeling study. [Internet] [Masters thesis]. Universiteit Utrecht; 2016. [cited 2021 Apr 11].
Available from: http://dspace.library.uu.nl:8080/handle/1874/325647.
Council of Science Editors:
Weekenstroo M. The controlling parameters of the structural style in the Oslo-Asker section: A field and analogue modeling study. [Masters Thesis]. Universiteit Utrecht; 2016. Available from: http://dspace.library.uu.nl:8080/handle/1874/325647
University of Cambridge
30.
Cheng, Xiang.
TFTs circuit simulation models and analogue building block designs.
Degree: PhD, 2018, University of Cambridge
URL: https://www.repository.cam.ac.uk/bitstream/1810/271853/6/Cheng-2018-PhD.jpg
;
https://www.repository.cam.ac.uk/bitstream/1810/271853/5/Cheng-2018-PhD.txt
;
https://www.repository.cam.ac.uk/bitstream/1810/271853/4/650a53fe-a4a7-45be-96d5-42856d1709cc.zip
;
https://www.repository.cam.ac.uk/bitstream/1810/271853/3/license.txt
;
https://www.repository.cam.ac.uk/bitstream/1810/271853/2/650a53fe-a4a7-45be-96d5-42856d1709cc_confirmations.txt
;
https://www.repository.cam.ac.uk/bitstream/1810/271853/1/Cheng-2018-PhD
► Building functional thin-film-transistor (TFT) circuits is crucial for applications such as wearable, implantable and transparent electronics. Therefore, developing a compact model of an emerging semiconductor…
(more)
▼ Building functional thin-film-transistor (TFT) circuits is crucial for applications such as wearable, implantable and transparent electronics. Therefore, developing a compact model of an emerging semiconductor material for accurate circuit simulation is the most fundamental requirement for circuit design. Further, unique analogue building blocks are needed due to the specific properties and non-idealities of TFTs.
This dissertation reviews the major developments in thin-film transistor (TFT) modelling for the computer-aided design (CAD) and simulation of circuits and systems. Following the progress in recent years on oxide TFTs, we have successfully developed a Verilog-AMS model called the CAMCAS model, which supports computer-aided circuit simulation of oxide-TFTs, with the potential to be extended to other types of TFT technology families.
For analogue applications, an accurate small signal model for thin film transistors (TFTs) is presented taking into account non-idealities such as contact resistance, parasitic capacitance, and threshold voltage shift to exhibit higher accuracy in comparison with the adapted CMOS model. The model is used to extract the zeros and poles of the frequency response in analogue circuits.
In particular, we consider the importance of device-circuit interactions (DCI) when designing thin film transistor circuits and systems and subsequently examine temperature- and process-induced variations and propose a way to evaluate the maximum achievable intrinsic performance of the TFT. This is aimed at determining when DCI becomes crucial for a specific application. Compensation methods are reviewed to show examples of how DCI is considered in the design of AMOLED displays.
Based on these design considerations, analogue building blocks including voltage and current references and differential amplifier stages have been designed to expand the analogue library specifically for TFT circuit design. The VT shift problem has been compensated based on unique circuit structures.
For a future generation of application, where ultra low power consumption is a critical requirement, we investigate the TFT’s subthreshold operation through examining several figures of merit including intrinsic gain (Ai), transconductance efficiency (gm/IDS) and cut-off frequency (fT). Here, we consider design sensitivity for biasing circuitry and the impact of device variations on low power circuit behaviour.
Subjects/Keywords: Thin film transistor; analogue circuit; Transistor modelling
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APA (6th Edition):
Cheng, X. (2018). TFTs circuit simulation models and analogue building block designs. (Doctoral Dissertation). University of Cambridge. Retrieved from https://www.repository.cam.ac.uk/bitstream/1810/271853/6/Cheng-2018-PhD.jpg ; https://www.repository.cam.ac.uk/bitstream/1810/271853/5/Cheng-2018-PhD.txt ; https://www.repository.cam.ac.uk/bitstream/1810/271853/4/650a53fe-a4a7-45be-96d5-42856d1709cc.zip ; https://www.repository.cam.ac.uk/bitstream/1810/271853/3/license.txt ; https://www.repository.cam.ac.uk/bitstream/1810/271853/2/650a53fe-a4a7-45be-96d5-42856d1709cc_confirmations.txt ; https://www.repository.cam.ac.uk/bitstream/1810/271853/1/Cheng-2018-PhD
Chicago Manual of Style (16th Edition):
Cheng, Xiang. “TFTs circuit simulation models and analogue building block designs.” 2018. Doctoral Dissertation, University of Cambridge. Accessed April 11, 2021.
https://www.repository.cam.ac.uk/bitstream/1810/271853/6/Cheng-2018-PhD.jpg ; https://www.repository.cam.ac.uk/bitstream/1810/271853/5/Cheng-2018-PhD.txt ; https://www.repository.cam.ac.uk/bitstream/1810/271853/4/650a53fe-a4a7-45be-96d5-42856d1709cc.zip ; https://www.repository.cam.ac.uk/bitstream/1810/271853/3/license.txt ; https://www.repository.cam.ac.uk/bitstream/1810/271853/2/650a53fe-a4a7-45be-96d5-42856d1709cc_confirmations.txt ; https://www.repository.cam.ac.uk/bitstream/1810/271853/1/Cheng-2018-PhD.
MLA Handbook (7th Edition):
Cheng, Xiang. “TFTs circuit simulation models and analogue building block designs.” 2018. Web. 11 Apr 2021.
Vancouver:
Cheng X. TFTs circuit simulation models and analogue building block designs. [Internet] [Doctoral dissertation]. University of Cambridge; 2018. [cited 2021 Apr 11].
Available from: https://www.repository.cam.ac.uk/bitstream/1810/271853/6/Cheng-2018-PhD.jpg ; https://www.repository.cam.ac.uk/bitstream/1810/271853/5/Cheng-2018-PhD.txt ; https://www.repository.cam.ac.uk/bitstream/1810/271853/4/650a53fe-a4a7-45be-96d5-42856d1709cc.zip ; https://www.repository.cam.ac.uk/bitstream/1810/271853/3/license.txt ; https://www.repository.cam.ac.uk/bitstream/1810/271853/2/650a53fe-a4a7-45be-96d5-42856d1709cc_confirmations.txt ; https://www.repository.cam.ac.uk/bitstream/1810/271853/1/Cheng-2018-PhD.
Council of Science Editors:
Cheng X. TFTs circuit simulation models and analogue building block designs. [Doctoral Dissertation]. University of Cambridge; 2018. Available from: https://www.repository.cam.ac.uk/bitstream/1810/271853/6/Cheng-2018-PhD.jpg ; https://www.repository.cam.ac.uk/bitstream/1810/271853/5/Cheng-2018-PhD.txt ; https://www.repository.cam.ac.uk/bitstream/1810/271853/4/650a53fe-a4a7-45be-96d5-42856d1709cc.zip ; https://www.repository.cam.ac.uk/bitstream/1810/271853/3/license.txt ; https://www.repository.cam.ac.uk/bitstream/1810/271853/2/650a53fe-a4a7-45be-96d5-42856d1709cc_confirmations.txt ; https://www.repository.cam.ac.uk/bitstream/1810/271853/1/Cheng-2018-PhD
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