subject:(alzheimers)

University of Manchester

1. Noble, Elizabeth. The molecular mechanisms linking amyloid-beta, the prion protein and tau in Alzheimer's disease.

Degree: 2017, University of Manchester

URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:306712

► Several lines of evidence suggest that the expression of the cellular prion protein (PrPC) is altered with age and in sporadic Alzheimer’s disease, however, published… (more)

▼ Several lines of evidence suggest that the expression of the cellular prion protein (PrPC) is altered with age and in sporadic Alzheimer’s disease, however, published results have been contradictory. Furthermore, a relationship between the expression of PrPC and Tau has started to emerge. We have revealed a specific relationship between the expression of PrPC and Tau in neuroblastoma cell lines and transgenic mouse models. In addition, we identified that the expression levels of PrPC are reduced in multiple brain regions following the progression of sporadic Alzheimer’s disease. Furthermore, the reduction in PrPC expression significantly correlated with the reduction in Tau expression and coincided with an increase in Tau pathology. In addition, data from neuroblastoma cell lines implicated the glycosylphosphatidylinositol (GPI)-anchor and in part the localisation of PrPC to lipid rafts in mediating these alterations to Tau. We hypothesise that the reduction in PrPC expression reflects a primary mechanism in Alzheimer’s disease pathogenesis and indirectly triggers the reduction in Tau expression which subsequently contributes to neuronal destabilisation and disruption to neuronal function. Soluble oligomeric forms of amyloid-beta are the primary pathogenic species in Alzheimer’s disease and strongly correlate with the presence and severity of cognitive decline. PrPC acts as a high affinity neuronal receptor for amyloid-beta oligomers and triggers pathogenic signaling cascades which induce synaptic impairment and further exacerbate neuronal destabilisation. We demonstrated that Flotillin-1 and the lipid raft localisation of PrPC are essential for the binding of amyloid-beta oligomers to PrPC. Furthermore, the metabotropic glutamate receptor, mGluR5 plays a pivotal role in the aberrant signaling of PrPC, and this PrPC/mGluR5 complex provides a mechanistic link between extracellular amyloid-beta oligomers and intracellular Tau phosphorylation, by Fyn kinase, Pyk2 and possibly by inactivation of the protein phosphatase, PP2A. Considering there is now strong evidence that Tau is the mediator of amyloid-beta induced toxicity, the reduction in Tau levels mediated by PrPC may be a protective mechanism. amyloid-beta oligomers interact with a multitude of neuronal receptors in addition to PrPC. It is likely that activation of multiple receptor complexes and signalling cascades are responsible for synaptic impairment and Tau phosphorylation induced by amyloid-beta, however, these complexes remain to be fully determined. Investigating amyloid-beta oligomer induced Tau phosphorylation in vitro has proven challenging, however, we suggest that a functional, mature, neuronal model is necessary to induce the complex mechanisms linking extracellular amyloid-beta oligomers and the phosphorylation of intracellular Tau. A greater understanding of the complex relationship between amyloid-beta, PrPC and Tau will aid in our understanding of the molecular mechanisms underlying Alzheimer’s disease and in the discovery of novel therapeutic… Advisors/Committee Members: PICKERING-BROWN, STUART SM, Pickering-Brown, Stuart, Hooper, Nigel.

Subjects/Keywords: Alzheimers; Amyloid; Prion protein; Tau

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APA (6^th Edition):

Noble, E. (2017). The molecular mechanisms linking amyloid-beta, the prion protein and tau in Alzheimer's disease. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:306712

Chicago Manual of Style (16^th Edition):

Noble, Elizabeth. “The molecular mechanisms linking amyloid-beta, the prion protein and tau in Alzheimer's disease.” 2017. Doctoral Dissertation, University of Manchester. Accessed March 09, 2021. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:306712.

MLA Handbook (7^th Edition):

Noble, Elizabeth. “The molecular mechanisms linking amyloid-beta, the prion protein and tau in Alzheimer's disease.” 2017. Web. 09 Mar 2021.

Vancouver:

Noble E. The molecular mechanisms linking amyloid-beta, the prion protein and tau in Alzheimer's disease. [Internet] [Doctoral dissertation]. University of Manchester; 2017. [cited 2021 Mar 09]. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:306712.

Council of Science Editors:

Noble E. The molecular mechanisms linking amyloid-beta, the prion protein and tau in Alzheimer's disease. [Doctoral Dissertation]. University of Manchester; 2017. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:306712

University of Debrecen

2. Halfin, Maxim. The effect of western diet and lifestyle on our civilization .

Degree: DE – Általános Orvostudományi Kar, 2014, University of Debrecen

URL: http://hdl.handle.net/2437/194724

The effect of modern and post agricultural revolution diet and sedentary lifestyle on our health in particularly neuropsychiatric diseases such as Alzheimer's dementia, OCD and depression Advisors/Committee Members: Frecska, Ede (advisor), University of Debrecen::Faculty of Medicine::Department of Psychiatry (advisor).

Subjects/Keywords: Neolithic revolution; alzheimers; Dementia

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APA (6^th Edition):

Halfin, M. (2014). The effect of western diet and lifestyle on our civilization . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/194724

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Halfin, Maxim. “The effect of western diet and lifestyle on our civilization .” 2014. Thesis, University of Debrecen. Accessed March 09, 2021. http://hdl.handle.net/2437/194724.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Halfin, Maxim. “The effect of western diet and lifestyle on our civilization .” 2014. Web. 09 Mar 2021.

Vancouver:

Halfin M. The effect of western diet and lifestyle on our civilization . [Internet] [Thesis]. University of Debrecen; 2014. [cited 2021 Mar 09]. Available from: http://hdl.handle.net/2437/194724.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Halfin M. The effect of western diet and lifestyle on our civilization . [Thesis]. University of Debrecen; 2014. Available from: http://hdl.handle.net/2437/194724

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Edith Cowan University

3. Krishnaswamy, Sudarsan. Reconstructing the gamma-secretase complex using the MultiBac baculovirus system for expression of heterologous multi-protein complexes.

Degree: 2010, Edith Cowan University

URL: https://ro.ecu.edu.au/theses/1899

► A small 4 kDa peptide, referred to as β-amyloid (Aβ), which characteristically accumulates and is deposited in the Alzheimer‟s disease (AD) brain, is known to… (more)

▼ A small 4 kDa peptide, referred to as β-amyloid (Aβ), which characteristically accumulates and is deposited in the Alzheimer‟s disease (AD) brain, is known to play a central role in the disease pathogenesis. The Aβ peptide is generated by proteolytic processing of its larger parent molecule, the amyloid precursor protein (APP). The final stage in this process, which releases the Aβ peptide, is the cleavage of the APP-Cterminal fragment (APP-C99/C100) by a multi-subunit enzyme complex is referred to as γ-secretase. The enzyme‟s ability to cleave a number of substrates has hampered the development of suitable inhibitors that target γ-secretase with the aim of specifically reducing Aβ production. A clearer understanding of the enzyme‟s structure and function is required in order to develop more specific therapeutic agents that will attenuate/modulate γ-secretase activity. Four core proteins, namely Presenilin (PS), Nicastrin (NCT), Anterior-pharynx defective homolog-1 (aph1aL/ aph1aS/ aph1b) and Presenilin enhancer-2 (pen2), interact to form the active γ-secretase complex. The assembly and function of the enzyme components are slowly becoming apparent. However, there are many unknown/ understudied aspects of the γ-secretase enzyme complex. Reconstructing the γ-secretase complex using appropriate protein expression models is required to obtain further insight into the structure and function of this unusual enzyme. One such in vitro system is the baculoviral expression system. The major objective of this thesis was to use a unique baculoviral expression system (referred to as MultiBac) to express four protein components of the γ-secretase complex and to assess the ability of the reconstituted enzyme to cleave the direct precursor to Aβ: APP-C100. This MultiBac is a novel highly versatile system that has been devised to generate recombinant baculovirus DNA that can be used to express multi-subunit protein complexes. The basis of the system is the use of transfer vectors to facilitate the assembly of polycistronic expression cassettes in the pFBDM vector, ultimately generating one baculovirus expressing multiple proteins, negating the need of multiple viruses for the expression of multi-subunit complexes. This, results in improved protein production and also in equivalent amounts, which is essential for any type of structural analysis, particularly for multi-subunit membrane bound complexes such as γ-secretase. In addition, the versatility of the pFBDM vector facilitates the incorporation of variations within the multi-protein complex such as mutations or different isoforms of complex components, thus providing more models which can be used to to gain further insight into critical active domains with the protein complex. Here, I detail the use of the MultiBac protein expression system to reconstruct the γ- secretase complex. Difficulties in generating some of the inserts required and expressing all of the protein components were experienced in initial attempts to use this system for reconstituting γ-secretase activity.…

Subjects/Keywords: Alzheimers; peptides; Geriatrics; Neurosciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Krishnaswamy, S. (2010). Reconstructing the gamma-secretase complex using the MultiBac baculovirus system for expression of heterologous multi-protein complexes. (Thesis). Edith Cowan University. Retrieved from https://ro.ecu.edu.au/theses/1899

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Krishnaswamy, Sudarsan. “Reconstructing the gamma-secretase complex using the MultiBac baculovirus system for expression of heterologous multi-protein complexes.” 2010. Thesis, Edith Cowan University. Accessed March 09, 2021. https://ro.ecu.edu.au/theses/1899.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Krishnaswamy, Sudarsan. “Reconstructing the gamma-secretase complex using the MultiBac baculovirus system for expression of heterologous multi-protein complexes.” 2010. Web. 09 Mar 2021.

Vancouver:

Krishnaswamy S. Reconstructing the gamma-secretase complex using the MultiBac baculovirus system for expression of heterologous multi-protein complexes. [Internet] [Thesis]. Edith Cowan University; 2010. [cited 2021 Mar 09]. Available from: https://ro.ecu.edu.au/theses/1899.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Krishnaswamy S. Reconstructing the gamma-secretase complex using the MultiBac baculovirus system for expression of heterologous multi-protein complexes. [Thesis]. Edith Cowan University; 2010. Available from: https://ro.ecu.edu.au/theses/1899

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

4. Wilsson, Fanny. Anhörigas upplevelser av att leva med en person som har Alzheimers sjukdom : En kvalitativ studie.

Degree: 2016, , Department of Health

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:bth-12141

► Bakgrund: Alzheimers är en kronisk demenssjukdom som främst drabbar personer över 65 år. Personen som drabbas av Alzheimers sjukdom försämras gradvis och det kan… (more)

Subjects/Keywords: Alzheimers sjukdom; anhöriga; upplevelser

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APA (6^th Edition):

Wilsson, F. (2016). Anhörigas upplevelser av att leva med en person som har Alzheimers sjukdom : En kvalitativ studie. (Thesis). , Department of Health. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:bth-12141

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wilsson, Fanny. “Anhörigas upplevelser av att leva med en person som har Alzheimers sjukdom : En kvalitativ studie.” 2016. Thesis, , Department of Health. Accessed March 09, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-12141.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wilsson, Fanny. “Anhörigas upplevelser av att leva med en person som har Alzheimers sjukdom : En kvalitativ studie.” 2016. Web. 09 Mar 2021.

Vancouver:

Wilsson F. Anhörigas upplevelser av att leva med en person som har Alzheimers sjukdom : En kvalitativ studie. [Internet] [Thesis]. , Department of Health; 2016. [cited 2021 Mar 09]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:bth-12141.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wilsson F. Anhörigas upplevelser av att leva med en person som har Alzheimers sjukdom : En kvalitativ studie. [Thesis]. , Department of Health; 2016. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:bth-12141

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Halmstad University

5. Jedemark, Jessika. Är himlen grön, så är den grön : Erfarenheter av att leva med och vårda en anhörig med Alzheimers sjukdom.

Degree: Social and Health Sciences (HOS), 2011, Halmstad University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-16890

►

Alzheimers är en sjukdom som ökar i Sverige. När någon diagnostiseras med Alzheimers sjukdom förändras även anhörigas liv och därför kallas Alzheimers för ”de… (more)

▼

Alzheimers är en sjukdom som ökar i Sverige. När någon diagnostiseras med Alzheimers sjukdom förändras även anhörigas liv och därför kallas Alzheimers för ”de anhörigas sjukdom”. Sjuksköterskan behöver förståelse för hur anhörigas livssituation förändras och vad det innebär att ta rollen som anhörigvårdare. Då anhöriga innehar stor kunskap om individen de vårdar skall sjuksköterskan beakta anhörigas kompetens och erfarenhet för att optimera vårdrelationen. Syftet var att beskriva anhörigvårdares erfarenheter av att leva och vårda en anhörig med Alzheimers sjukdom. Arbetet utfördes som en litteraturstudie utifrån 13 vetenskapliga artiklar som granskades, analyserades samt färgkodades. Vid kodningen framkom fem kategorier som var de mest karaktäristiska erfarenheterna. I resultatet framkom det att anhöriga saknade kunskap om sjukdomen, att den nya rollen innebar en förändrad relation och nya prioriteringar. Att känna förlust av den tidigare relationen mellan anhörigvårdaren och personen med Alzheimers var en erfarenhet som delades av många anhörigvårdare. Bristen på egentid och minskat socialt umgänge kunde ses som negativa erfarenheter men resultatet visar att anhörigvårdare lär sig att leva i nuet och uppskatta vardagliga ting. Sjuksköterskan behöver mer utbildning i att möta och stödja anhöriga för att få förståelse. Vidare forskning bör fokusera på manliga anhörigvårdares erfarenheter då de är underrepresenterade i forskningen.

Alzheimer's is a disease that is increasing in Sweden. When a person is diagnosed with Alzheimer's disease it change the lives of their relatives, this is why Alzheimer's is called ”the relatives’ illness”. The nurses need a greater understanding in how the families living situation is changed by the disease and means to take on the role as a caregiver. The caregivers have great knowledge about the person they care for. The nurse has to pay attention to the knowledge and the experience of caregivers to optimize the care relationship. The aim of this study was to describe the caregivers’ experiences of living with and caring for a relative with Alzheimer's disease. The work was carried out as a literature study where 13 scientific articles were examined, analyzed and coded in colours. The most prominent experiences that arose were divided into five categories. The results showed that relatives felt a lack of knowledge about the disease, that the new role meant a changed relationship and new priorities. The feeling of having lost the previous relationship between the caregiver and the person with Alzheimer's disease was an experience shared by many carers. The lack of leisure time and reduced social interaction could be seen as negative factors, but the result shows that family caregivers learn to live in the moment and appreciate the everyday things. The nurses are in need of more training in how to meet and support the affected families to get a deeper understanding in the outcome of the disease. Further research should focus on male caregivers and their experiences because they…

Subjects/Keywords: Alzheimers sjukdom; anhörigvårdare; upplevelser

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Jedemark, J. (2011). Är himlen grön, så är den grön : Erfarenheter av att leva med och vårda en anhörig med Alzheimers sjukdom. (Thesis). Halmstad University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-16890

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jedemark, Jessika. “Är himlen grön, så är den grön : Erfarenheter av att leva med och vårda en anhörig med Alzheimers sjukdom.” 2011. Thesis, Halmstad University. Accessed March 09, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-16890.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jedemark, Jessika. “Är himlen grön, så är den grön : Erfarenheter av att leva med och vårda en anhörig med Alzheimers sjukdom.” 2011. Web. 09 Mar 2021.

Vancouver:

Jedemark J. Är himlen grön, så är den grön : Erfarenheter av att leva med och vårda en anhörig med Alzheimers sjukdom. [Internet] [Thesis]. Halmstad University; 2011. [cited 2021 Mar 09]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-16890.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jedemark J. Är himlen grön, så är den grön : Erfarenheter av att leva med och vårda en anhörig med Alzheimers sjukdom. [Thesis]. Halmstad University; 2011. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-16890

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Vanderbilt University

6. Barton, Shawn Michael. Innovations in Delivery of Theranostic Agents Across Biological Barriers for Applications in Alzheimer’s Disease.

Degree: PhD, Neuroscience, 2018, Vanderbilt University

URL: http://hdl.handle.net/1803/15303

► Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by memory loss, language deficits, and executive dysfunction. Currently, there are no disease-modifying therapeutics available and major… (more)

▼ Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by memory loss, language deficits, and executive dysfunction. Currently, there are no disease-modifying therapeutics available and major clinical trials have yielded no therapeutic benefits. Efforts to develop neurotherapeutics for AD and other neurologic disorders have been hindered by limited bioavailability due to the presence of the blood brain barrier (BBB). Previous attempts to target and clear amyloid beta (Aβ) plaques, a key pathologic mediator of AD, have had limited clinical success due to this biological barrier. To address this issue, we demonstrate in this work two distinct methods for improving delivery of theranostic agents to the brain. In one approach, using preclinical transgenic mouse models of AD, the BBB was breached in a condition amenable to acute inflammation, which allowed improved delivery of small and large materials to the brain parenchyma. Given the complexity of the biological and immunological events that emerge during inflammation, questions arise over the relative benefits and pernicious effects of this approach. Meanwhile, we demonstrated that aerosol administration also improves delivery to the brain without requiring BBB disruption, and thus may be more applicable to clinical translation. From a developmental biology perspective, the retina is part of the central nervous system, functioning as a window to the brain from where the neuronal activity in the retina is transferred to the higher order visual processing brain regions via the optic nerve. Our hypothesis is that if Aβ deposits are present in the retina, they could serve as a surrogate biomarker for those in the brain and thus offers an opportunity for noninvasive Aβ imaging. Toward that approach, we are developing a method of retinal plaque detection using fluorescent Aβ-binding molecules that could be visualized using noninvasive retinal imaging. Such a test could be used to clinically evaluate retinal pathology as a predictive biomarker for future development of AD. Advisors/Committee Members: John Gore (committee member), Douglas McMahon (committee member), Wellington Pham (committee member), Manus Donahue (Committee Chair).

Subjects/Keywords: Alzheimers; amyloid; retina; 5XFAD

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Barton, S. M. (2018). Innovations in Delivery of Theranostic Agents Across Biological Barriers for Applications in Alzheimer’s Disease. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/15303

Chicago Manual of Style (16^th Edition):

Barton, Shawn Michael. “Innovations in Delivery of Theranostic Agents Across Biological Barriers for Applications in Alzheimer’s Disease.” 2018. Doctoral Dissertation, Vanderbilt University. Accessed March 09, 2021. http://hdl.handle.net/1803/15303.

MLA Handbook (7^th Edition):

Barton, Shawn Michael. “Innovations in Delivery of Theranostic Agents Across Biological Barriers for Applications in Alzheimer’s Disease.” 2018. Web. 09 Mar 2021.

Vancouver:

Barton SM. Innovations in Delivery of Theranostic Agents Across Biological Barriers for Applications in Alzheimer’s Disease. [Internet] [Doctoral dissertation]. Vanderbilt University; 2018. [cited 2021 Mar 09]. Available from: http://hdl.handle.net/1803/15303.

Council of Science Editors:

Barton SM. Innovations in Delivery of Theranostic Agents Across Biological Barriers for Applications in Alzheimer’s Disease. [Doctoral Dissertation]. Vanderbilt University; 2018. Available from: http://hdl.handle.net/1803/15303

University of Tasmania

7. Klekociuk, S. Longitudinal profiling of mild cognitive impairment subtypes.

Degree: 2013, University of Tasmania

URL: https://eprints.utas.edu.au/18256/1/front-Klekociuk-thesis.pdf ; https://eprints.utas.edu.au/18256/2/Whole-Klekociuk-thesis-excluding-pub-mat.pdf ; https://eprints.utas.edu.au/18256/3/Whole-Klekociuk-thesis-inc-pub-mat.pdf ; https://eprints.utas.edu.au/18256/10/Appendix%20A.zip ; https://eprints.utas.edu.au/18256/11/Appendix%20B.zip ; https://eprints.utas.edu.au/18256/12/Appendix%20C.zip ; https://eprints.utas.edu.au/18256/13/Appendix%20D.zip

► Mild Cognitive Impairment (MCI) was originally conceptualized as a condition that manifested prior to the onset of clinical dementia, particularly Alzheimer’s disease. However, longitudinal studies… (more)

▼ Mild Cognitive Impairment (MCI) was originally conceptualized as a condition that manifested prior to the onset of clinical dementia, particularly Alzheimer’s disease. However, longitudinal studies show that MCI has an unstable course and may lead to various outcomes including dementia, but also stability of cognitive deficits or recovery to age appropriate levels of functioning. As a result, the status of MCI as a genuine diagnostic entity remains questionable. The aim of the present thesis was to examine the validity of the MCI concept by tracking groups of individuals classified into one of the MCI subtypes and to monitor their neuropsychological profiles over time. To avoid previous criticisms of circularity, participants were classified as MCI on a neuropsychological test battery and then reassessed longitudinally using an alternate battery of neuropsychological tests. At each stage of testing, participants were assessed on a comprehensive neuropsychological test battery tapping the cognitive domains implicated in MCI. Findings from this thesis indicate that multiple domain amnestic MCI may be the most valid subtype of MCI due to consistently poor performance over time on a range of neuropsychological measures. Results also demonstrate that those who are likely to remain on the MCI spectrum can be differentiated from healthy older adults using reliable and valid measures of sustained attention, semantic memory, verbal episodic memory, visual and verbal working memory, selective attention and strategy use. Despite these findings, evidence from this thesis indicates that existing MCI clinical criteria lack sufficient sensitivity and specificity. Although the concept of MCI remains useful, it cannot be considered a clinical diagnostic entity. Future research should prioritize the observation of those presenting with a multiple domain amnestic profile as these individuals may have the poorest prognosis. Further, studies must utilize comprehensive testing protocols to increase the sensitivity and specificity of identifying those with genuine subclinical impairments.

Subjects/Keywords: mild cognitive impairment; Aging; Alzheimers disease; Neuropsychology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Klekociuk, S. (2013). Longitudinal profiling of mild cognitive impairment subtypes. (Thesis). University of Tasmania. Retrieved from https://eprints.utas.edu.au/18256/1/front-Klekociuk-thesis.pdf ; https://eprints.utas.edu.au/18256/2/Whole-Klekociuk-thesis-excluding-pub-mat.pdf ; https://eprints.utas.edu.au/18256/3/Whole-Klekociuk-thesis-inc-pub-mat.pdf ; https://eprints.utas.edu.au/18256/10/Appendix%20A.zip ; https://eprints.utas.edu.au/18256/11/Appendix%20B.zip ; https://eprints.utas.edu.au/18256/12/Appendix%20C.zip ; https://eprints.utas.edu.au/18256/13/Appendix%20D.zip

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Klekociuk, S. “Longitudinal profiling of mild cognitive impairment subtypes.” 2013. Thesis, University of Tasmania. Accessed March 09, 2021. https://eprints.utas.edu.au/18256/1/front-Klekociuk-thesis.pdf ; https://eprints.utas.edu.au/18256/2/Whole-Klekociuk-thesis-excluding-pub-mat.pdf ; https://eprints.utas.edu.au/18256/3/Whole-Klekociuk-thesis-inc-pub-mat.pdf ; https://eprints.utas.edu.au/18256/10/Appendix%20A.zip ; https://eprints.utas.edu.au/18256/11/Appendix%20B.zip ; https://eprints.utas.edu.au/18256/12/Appendix%20C.zip ; https://eprints.utas.edu.au/18256/13/Appendix%20D.zip.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Klekociuk, S. “Longitudinal profiling of mild cognitive impairment subtypes.” 2013. Web. 09 Mar 2021.

Vancouver:

Klekociuk S. Longitudinal profiling of mild cognitive impairment subtypes. [Internet] [Thesis]. University of Tasmania; 2013. [cited 2021 Mar 09]. Available from: https://eprints.utas.edu.au/18256/1/front-Klekociuk-thesis.pdf ; https://eprints.utas.edu.au/18256/2/Whole-Klekociuk-thesis-excluding-pub-mat.pdf ; https://eprints.utas.edu.au/18256/3/Whole-Klekociuk-thesis-inc-pub-mat.pdf ; https://eprints.utas.edu.au/18256/10/Appendix%20A.zip ; https://eprints.utas.edu.au/18256/11/Appendix%20B.zip ; https://eprints.utas.edu.au/18256/12/Appendix%20C.zip ; https://eprints.utas.edu.au/18256/13/Appendix%20D.zip.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Klekociuk S. Longitudinal profiling of mild cognitive impairment subtypes. [Thesis]. University of Tasmania; 2013. Available from: https://eprints.utas.edu.au/18256/1/front-Klekociuk-thesis.pdf ; https://eprints.utas.edu.au/18256/2/Whole-Klekociuk-thesis-excluding-pub-mat.pdf ; https://eprints.utas.edu.au/18256/3/Whole-Klekociuk-thesis-inc-pub-mat.pdf ; https://eprints.utas.edu.au/18256/10/Appendix%20A.zip ; https://eprints.utas.edu.au/18256/11/Appendix%20B.zip ; https://eprints.utas.edu.au/18256/12/Appendix%20C.zip ; https://eprints.utas.edu.au/18256/13/Appendix%20D.zip

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Cornell University

8. Kim, Hannah. The Effect Of Environmental Design And Sensory Stimulation On People With Alzheimer'S Disease: An Exploratory Study Of The Family Visit Program.

Degree: MA, Design, 2014, Cornell University

URL: http://hdl.handle.net/1813/36080

► Alzheimer's disease is a progressive and fatal brain disorder that causes cognitive decline and eventual loss of the ability to interact and communicate with others.… (more)

Subjects/Keywords: Design Environment; Alzheimers Disease; Sensory Stimulation

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APA (6^th Edition):

Kim, H. (2014). The Effect Of Environmental Design And Sensory Stimulation On People With Alzheimer'S Disease: An Exploratory Study Of The Family Visit Program. (Masters Thesis). Cornell University. Retrieved from http://hdl.handle.net/1813/36080

Chicago Manual of Style (16^th Edition):

Kim, Hannah. “The Effect Of Environmental Design And Sensory Stimulation On People With Alzheimer'S Disease: An Exploratory Study Of The Family Visit Program.” 2014. Masters Thesis, Cornell University. Accessed March 09, 2021. http://hdl.handle.net/1813/36080.

MLA Handbook (7^th Edition):

Kim, Hannah. “The Effect Of Environmental Design And Sensory Stimulation On People With Alzheimer'S Disease: An Exploratory Study Of The Family Visit Program.” 2014. Web. 09 Mar 2021.

Vancouver:

Kim H. The Effect Of Environmental Design And Sensory Stimulation On People With Alzheimer'S Disease: An Exploratory Study Of The Family Visit Program. [Internet] [Masters thesis]. Cornell University; 2014. [cited 2021 Mar 09]. Available from: http://hdl.handle.net/1813/36080.

Council of Science Editors:

Kim H. The Effect Of Environmental Design And Sensory Stimulation On People With Alzheimer'S Disease: An Exploratory Study Of The Family Visit Program. [Masters Thesis]. Cornell University; 2014. Available from: http://hdl.handle.net/1813/36080

Vanderbilt University

9. Watkins, Guy Richard. Regulation of PP2Ac stability – discovery of a novel α4 monoubiquitination-dependent mechanism that is altered in Alzheimer’s disease.

Degree: PhD, Pharmacology, 2012, Vanderbilt University

URL: http://hdl.handle.net/1803/13840

► Studies described in this thesis identify a novel mechanism for α4’s regulation of PP2Ac stability. α4 binds the PP2A catalytic subunit (PP2Ac) and the microtubule-associated… (more)

Subjects/Keywords: Opitz syndrome; phosphatase; ubiquitin; PP2A; Alzheimers disease

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APA (6^th Edition):

Watkins, G. R. (2012). Regulation of PP2Ac stability – discovery of a novel α4 monoubiquitination-dependent mechanism that is altered in Alzheimer’s disease. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/13840

Chicago Manual of Style (16^th Edition):

Watkins, Guy Richard. “Regulation of PP2Ac stability – discovery of a novel α4 monoubiquitination-dependent mechanism that is altered in Alzheimer’s disease.” 2012. Doctoral Dissertation, Vanderbilt University. Accessed March 09, 2021. http://hdl.handle.net/1803/13840.

MLA Handbook (7^th Edition):

Watkins, Guy Richard. “Regulation of PP2Ac stability – discovery of a novel α4 monoubiquitination-dependent mechanism that is altered in Alzheimer’s disease.” 2012. Web. 09 Mar 2021.

Vancouver:

Watkins GR. Regulation of PP2Ac stability – discovery of a novel α4 monoubiquitination-dependent mechanism that is altered in Alzheimer’s disease. [Internet] [Doctoral dissertation]. Vanderbilt University; 2012. [cited 2021 Mar 09]. Available from: http://hdl.handle.net/1803/13840.

Council of Science Editors:

Watkins GR. Regulation of PP2Ac stability – discovery of a novel α4 monoubiquitination-dependent mechanism that is altered in Alzheimer’s disease. [Doctoral Dissertation]. Vanderbilt University; 2012. Available from: http://hdl.handle.net/1803/13840

Vanderbilt University

10. Mason, Emily Jo. Cerebrovasculature and Cognition in Middle Aged Adults At Risk for Alzheimer's Disease.

Degree: PhD, Neuroscience, 2016, Vanderbilt University

URL: http://hdl.handle.net/1803/14702

► Alzheimer’s disease (AD) is the most common form of dementia. There is currently no treatment that will delay, halt, or prevent the onset of AD.… (more)

Subjects/Keywords: Risk; Cerebrovasculature; Neuroimaging; Cognition; Alzheimers Disease

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APA (6^th Edition):

Mason, E. J. (2016). Cerebrovasculature and Cognition in Middle Aged Adults At Risk for Alzheimer's Disease. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/14702

Chicago Manual of Style (16^th Edition):

Mason, Emily Jo. “Cerebrovasculature and Cognition in Middle Aged Adults At Risk for Alzheimer's Disease.” 2016. Doctoral Dissertation, Vanderbilt University. Accessed March 09, 2021. http://hdl.handle.net/1803/14702.

MLA Handbook (7^th Edition):

Mason, Emily Jo. “Cerebrovasculature and Cognition in Middle Aged Adults At Risk for Alzheimer's Disease.” 2016. Web. 09 Mar 2021.

Vancouver:

Mason EJ. Cerebrovasculature and Cognition in Middle Aged Adults At Risk for Alzheimer's Disease. [Internet] [Doctoral dissertation]. Vanderbilt University; 2016. [cited 2021 Mar 09]. Available from: http://hdl.handle.net/1803/14702.

Council of Science Editors:

Mason EJ. Cerebrovasculature and Cognition in Middle Aged Adults At Risk for Alzheimer's Disease. [Doctoral Dissertation]. Vanderbilt University; 2016. Available from: http://hdl.handle.net/1803/14702

Vanderbilt University

11. Barrett, Paul John. Structural and Cholesterol Binding Properties of the Amyloid Precursor Protein C-Terminal Fragment C99 and the Etiology of Alzheimer's Disease.

Degree: PhD, Biochemistry, 2013, Vanderbilt University

URL: http://hdl.handle.net/1803/14117

► Biochemistry Structural and Cholesterol Binding Properties of the Amyloid Precursor Protein C-Terminal Fragment C99 and the Etiology of Alzheimer’s Disease Paul John Barrett Dissertation under… (more)

▼ Biochemistry Structural and Cholesterol Binding Properties of the Amyloid Precursor Protein C-Terminal Fragment C99 and the Etiology of Alzheimer’s Disease Paul John Barrett Dissertation under the direction of Professor Charles Sanders Alzheimer’s Disease (AD) is a severe form of dementia that currently affects nearly 40 million people worldwide, a number that is estimated to increase by the year 2050 to nearly 120 million. The production and oligomerization of the amyloid beta polypeptides (Aβ) is widely thought to play a central role in AD onset and progression. Aβ oligomers are neurotoxic, such that factors that increase Aβ production and propensity to oligomerize or that reduce its degradation and transport out of the brain are viewed as pro-AD risk factors. Recently, it has been established that cholesterol may be a pro-AD risk factor, but this mechanism is still highly controversial. Aβ polypeptides are derived from two step proteolytic processing of the amyloid precursor protein (APP) by the enzymes β- and γ-secretase. This thesis will investigate both how the structure of C99 and the ability of C99 to bind cholesterol regulate and promote these cleavage events. First, this thesis will focus on the three dimensional structure determination of C99 using NMR spectroscopy. Prior to this work, much had been inferred about how the structure of C99 regulated the cleavage events of the amyloidogenic pathway, but without an actual structure, this work was incomplete. I demonstrate that C99 contains a membrane embedded helical turn N-terminal of the transmembrane helix, and that the transmembrane helix is both highly curved and flexible in nature. We hypothesize from this work that the curved structure of the transmembrane helix allows for proper insertion in the γ-secretase complex, and may be a potential target for modulating Aβ production. Secondly, this thesis will focus on the mechanism that makes cholesterol a pro-AD risk factor. We have shown that not only can C99 specifically bind cholesterol, but that this binding event partitions C99 to cholesterol rich membrane domains. It is known that both β- and γ-secretase reside in these cholesterol rich membranes. These findings show that cholesterol binding by APP may be the first step in promoting Aβ formation during AD. Advisors/Committee Members: Walter Chazin (committee member), Bruce Carter (committee member), Anne Kenworthy (committee member), Richard Armstrong (committee member), Charles Sanders (Committee Chair).

Subjects/Keywords: Partitioning; APP; Structure; Membrane; Cholesterol; Alzheimers Disease

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APA (6^th Edition):

Barrett, P. J. (2013). Structural and Cholesterol Binding Properties of the Amyloid Precursor Protein C-Terminal Fragment C99 and the Etiology of Alzheimer's Disease. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/14117

Chicago Manual of Style (16^th Edition):

Barrett, Paul John. “Structural and Cholesterol Binding Properties of the Amyloid Precursor Protein C-Terminal Fragment C99 and the Etiology of Alzheimer's Disease.” 2013. Doctoral Dissertation, Vanderbilt University. Accessed March 09, 2021. http://hdl.handle.net/1803/14117.

MLA Handbook (7^th Edition):

Barrett, Paul John. “Structural and Cholesterol Binding Properties of the Amyloid Precursor Protein C-Terminal Fragment C99 and the Etiology of Alzheimer's Disease.” 2013. Web. 09 Mar 2021.

Vancouver:

Barrett PJ. Structural and Cholesterol Binding Properties of the Amyloid Precursor Protein C-Terminal Fragment C99 and the Etiology of Alzheimer's Disease. [Internet] [Doctoral dissertation]. Vanderbilt University; 2013. [cited 2021 Mar 09]. Available from: http://hdl.handle.net/1803/14117.

Council of Science Editors:

Barrett PJ. Structural and Cholesterol Binding Properties of the Amyloid Precursor Protein C-Terminal Fragment C99 and the Etiology of Alzheimer's Disease. [Doctoral Dissertation]. Vanderbilt University; 2013. Available from: http://hdl.handle.net/1803/14117

Punjabi University

12. Preet Anand. Synthesis and evaluation of acetylcholinesterase inhibitors for alzheimers disease; -.

Degree: Chemistry, 2012, Punjabi University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/13585

None

Reference p.183-216

Advisors/Committee Members: Singh, Baldev.

Subjects/Keywords: Chemistry; alzheimers disease

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APA (6^th Edition):

Anand, P. (2012). Synthesis and evaluation of acetylcholinesterase inhibitors for alzheimers disease; -. (Thesis). Punjabi University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/13585

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Anand, Preet. “Synthesis and evaluation of acetylcholinesterase inhibitors for alzheimers disease; -.” 2012. Thesis, Punjabi University. Accessed March 09, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/13585.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Anand, Preet. “Synthesis and evaluation of acetylcholinesterase inhibitors for alzheimers disease; -.” 2012. Web. 09 Mar 2021.

Vancouver:

Anand P. Synthesis and evaluation of acetylcholinesterase inhibitors for alzheimers disease; -. [Internet] [Thesis]. Punjabi University; 2012. [cited 2021 Mar 09]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/13585.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Anand P. Synthesis and evaluation of acetylcholinesterase inhibitors for alzheimers disease; -. [Thesis]. Punjabi University; 2012. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/13585

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

13. Kulas, Joshua. Amyloid Precursor Protein And Insulin Homeostasis.

Degree: PhD, Biomedical Sciences, 2018, University of North Dakota

URL: https://commons.und.edu/theses/2260

► Alzheimerâs disease (AD) is a neurodegenerative disease in which the brain progressively deteriorates resulting in cognitive decline, language impairment, diminished spatial awareness, memory loss… (more)

Subjects/Keywords: Alzheimers; Amyloid; APP; Diabetes; IDE; Pancreas

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APA (6^th Edition):

Kulas, J. (2018). Amyloid Precursor Protein And Insulin Homeostasis. (Doctoral Dissertation). University of North Dakota. Retrieved from https://commons.und.edu/theses/2260

Chicago Manual of Style (16^th Edition):

Kulas, Joshua. “Amyloid Precursor Protein And Insulin Homeostasis.” 2018. Doctoral Dissertation, University of North Dakota. Accessed March 09, 2021. https://commons.und.edu/theses/2260.

MLA Handbook (7^th Edition):

Kulas, Joshua. “Amyloid Precursor Protein And Insulin Homeostasis.” 2018. Web. 09 Mar 2021.

Vancouver:

Kulas J. Amyloid Precursor Protein And Insulin Homeostasis. [Internet] [Doctoral dissertation]. University of North Dakota; 2018. [cited 2021 Mar 09]. Available from: https://commons.und.edu/theses/2260.

Council of Science Editors:

Kulas J. Amyloid Precursor Protein And Insulin Homeostasis. [Doctoral Dissertation]. University of North Dakota; 2018. Available from: https://commons.und.edu/theses/2260

14. Davies, Julie. The novel role of the neuropeptides orexin and QRFP and their involvement in Alzheimer's disease.

Degree: PhD, 2014, Brunel University

URL: http://bura.brunel.ac.uk/handle/2438/9196 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.629959

► Alzheimer’s disease (AD) is a neurodegenerative disease which affects over 500,000 people in the UK. Worldwide 44 million people are affected by AD and other… (more)

▼ Alzheimer’s disease (AD) is a neurodegenerative disease which affects over 500,000 people in the UK. Worldwide 44 million people are affected by AD and other dementias. Most cases occur over the age of 65 and is characterised by gradual and increasing loss of cognitive function and behavioural abnormalities. The main causes are a build-up of the toxic protein amyloid-β (Aβ) and hyperphosphorylation of the microtubule stabilising protein: tau, leading to neurofibrillary tangles (NFT). These two hallmarks of disease result in neuronal damage and cell death causing associated symptoms and eventually death. Orexins (OX) are neuropeptides which function to regulate the sleep-wake cycle and feeding behaviour. They are produced from a prepro-orexin (PPO) molecule and cleaved into two isoforms: orexin-A (OXA) and orexin-B (OXB). OXA and OXB are the ligands for two G-protein coupled receptors (GPCR): orexin receptor 1 (OX1R) and orexin receptor 2 (OX2R). 50-80,000 OX producing neurons project to many areas of the brain including the lateral hypothalamus (LHA), locus coeruleus (LC), tuberomammillary nucleus (TMN), paraventricular nucleus (PVN) and raphe nuclei and from these areas regulate feeding and appetite and the sleep wake cycle through their receptors. QRFP is a newly discovered neuropeptide which exerts similar orexigenic activity including the control of feeding behaviour. It is the ligand for the GPCR GPR103, both of which are widely expressed in the brain and also in the retina, testes, thyroid, pituitary and prostate. GPR103 also shares 48 and 47% protein sequence homology with OX1R and OX2R respectively. It is in these tissues where it can exert other physiological functions including regulation of feeding, control of the gonadotropic axis and bone formation. The exact expression and signalling characteristics and physiological actions of QRFP/GPR103 are still poorly understood. It is through the physiological functions of the orexigenic system and the clinical symptoms observed in AD which suggests a possible link between the two. For example, in AD one of the main reasons for institutionalisation is the severely dysregulated sleep pattern that is experienced by sufferers. They experience increased nocturnal activity and early awakenings as well as hypersomnia and excessive daytime sleepiness; all of which is beyond what someone of the same age experiences. As well as this AD patients suffer from significant weight loss and a significant negative correlation has been identified between progression of disease and appetite. All of this points towards an involvement of the orexigenic system in AD. AD patients have been found to have a 40% loss of immunoreactive OX neurons and have severe reductions in circulating OXA. This led us to believe that the OX system is of vital importance in AD and could be targeted to ameliorate symptoms. Studies have implicated OX and OXR in memory processes, appetite regulation, and severe disturbances of the sleep-wake cycle all of which are phenotypes of AD. Given that they play a key…

Subjects/Keywords: 616.8; Alzheimers disease; Orexin; Neuropeptide; Neurology

10 more images…

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APA (6^th Edition):

Davies, J. (2014). The novel role of the neuropeptides orexin and QRFP and their involvement in Alzheimer's disease. (Doctoral Dissertation). Brunel University. Retrieved from http://bura.brunel.ac.uk/handle/2438/9196 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.629959

Chicago Manual of Style (16^th Edition):

Davies, Julie. “The novel role of the neuropeptides orexin and QRFP and their involvement in Alzheimer's disease.” 2014. Doctoral Dissertation, Brunel University. Accessed March 09, 2021. http://bura.brunel.ac.uk/handle/2438/9196 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.629959.

MLA Handbook (7^th Edition):

Davies, Julie. “The novel role of the neuropeptides orexin and QRFP and their involvement in Alzheimer's disease.” 2014. Web. 09 Mar 2021.

Vancouver:

Davies J. The novel role of the neuropeptides orexin and QRFP and their involvement in Alzheimer's disease. [Internet] [Doctoral dissertation]. Brunel University; 2014. [cited 2021 Mar 09]. Available from: http://bura.brunel.ac.uk/handle/2438/9196 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.629959.

Council of Science Editors:

Davies J. The novel role of the neuropeptides orexin and QRFP and their involvement in Alzheimer's disease. [Doctoral Dissertation]. Brunel University; 2014. Available from: http://bura.brunel.ac.uk/handle/2438/9196 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.629959

15. Andersson, Elin. Att axla ett vårdaransvar : Att vara anhörig till en närstående med Alzheimers sjukdom - en litteraturstudie.

Degree: Nursing, 2017, Umeå University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-131810

► Bakgrund: Alzheimers sjukdom påverkar inte bara den närstående med Alzheimer utan även anhöriga drabbas, både fysiskt och psykiskt då sjukdomen bidrar till stora förändringar… (more)

Subjects/Keywords: Alzheimers sjukdom; anhöriga; erfarenheter; Nursing; Omvårdnad

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APA (6^th Edition):

Andersson, E. (2017). Att axla ett vårdaransvar : Att vara anhörig till en närstående med Alzheimers sjukdom - en litteraturstudie. (Thesis). Umeå University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-131810

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Andersson, Elin. “Att axla ett vårdaransvar : Att vara anhörig till en närstående med Alzheimers sjukdom - en litteraturstudie.” 2017. Thesis, Umeå University. Accessed March 09, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-131810.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Andersson, Elin. “Att axla ett vårdaransvar : Att vara anhörig till en närstående med Alzheimers sjukdom - en litteraturstudie.” 2017. Web. 09 Mar 2021.

Vancouver:

Andersson E. Att axla ett vårdaransvar : Att vara anhörig till en närstående med Alzheimers sjukdom - en litteraturstudie. [Internet] [Thesis]. Umeå University; 2017. [cited 2021 Mar 09]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-131810.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Andersson E. Att axla ett vårdaransvar : Att vara anhörig till en närstående med Alzheimers sjukdom - en litteraturstudie. [Thesis]. Umeå University; 2017. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-131810

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

16. Svensson, Amanda Virkajärvi. Upplevelse att vara anhörigvårdare till en individ med Alzheimers sjukdom i hemmet. : Baserad på patografier.

Degree: 2016, , Department of Health

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:bth-11815

► Alzheimers sjukdom är den vanligaste demenssjukdom och står för 50-75 % av demenssjukdomar. Alzheimers sjukdom är ett snabbt växande hälsoproblem i dagens samhälle. Det… (more)

Subjects/Keywords: Alzheimers sjukdom; demens; närstående; anhörigvårdare; Nursing; Omvårdnad

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APA (6^th Edition):

Svensson, A. V. (2016). Upplevelse att vara anhörigvårdare till en individ med Alzheimers sjukdom i hemmet. : Baserad på patografier. (Thesis). , Department of Health. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:bth-11815

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Svensson, Amanda Virkajärvi. “Upplevelse att vara anhörigvårdare till en individ med Alzheimers sjukdom i hemmet. : Baserad på patografier.” 2016. Thesis, , Department of Health. Accessed March 09, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-11815.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Svensson, Amanda Virkajärvi. “Upplevelse att vara anhörigvårdare till en individ med Alzheimers sjukdom i hemmet. : Baserad på patografier.” 2016. Web. 09 Mar 2021.

Vancouver:

Svensson AV. Upplevelse att vara anhörigvårdare till en individ med Alzheimers sjukdom i hemmet. : Baserad på patografier. [Internet] [Thesis]. , Department of Health; 2016. [cited 2021 Mar 09]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:bth-11815.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Svensson AV. Upplevelse att vara anhörigvårdare till en individ med Alzheimers sjukdom i hemmet. : Baserad på patografier. [Thesis]. , Department of Health; 2016. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:bth-11815

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

17. Holte, Anna. Upplevelser av att vårda sin partner med Alzheimers sjukdom i hemmet : En kvalitativ litteraturstudie ur närståendeperspektiv.

Degree: 2012, , School of Health Science

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:bth-3993

► Bakgrund: Alzheimers sjukdom är den vanligaste demensformen i västvärlden. Många närstående vill så långt som möjligt under sjukdomsförloppet vårda sin partner i hemmet. De… (more)

Subjects/Keywords: Upplevelse; Alzheimers; sjukdom; Närstående; Informella; vårdgivare

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APA (6^th Edition):

Holte, A. (2012). Upplevelser av att vårda sin partner med Alzheimers sjukdom i hemmet : En kvalitativ litteraturstudie ur närståendeperspektiv. (Thesis). , School of Health Science. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:bth-3993

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Holte, Anna. “Upplevelser av att vårda sin partner med Alzheimers sjukdom i hemmet : En kvalitativ litteraturstudie ur närståendeperspektiv.” 2012. Thesis, , School of Health Science. Accessed March 09, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-3993.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Holte, Anna. “Upplevelser av att vårda sin partner med Alzheimers sjukdom i hemmet : En kvalitativ litteraturstudie ur närståendeperspektiv.” 2012. Web. 09 Mar 2021.

Vancouver:

Holte A. Upplevelser av att vårda sin partner med Alzheimers sjukdom i hemmet : En kvalitativ litteraturstudie ur närståendeperspektiv. [Internet] [Thesis]. , School of Health Science; 2012. [cited 2021 Mar 09]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:bth-3993.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Holte A. Upplevelser av att vårda sin partner med Alzheimers sjukdom i hemmet : En kvalitativ litteraturstudie ur närståendeperspektiv. [Thesis]. , School of Health Science; 2012. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:bth-3993

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Linnaeus University

18. Sunnman, Jenny. Anhörigas upplevelser av att leva med och vårda en person med Alzheimers sjukdom i hemmet : En litteraturstudie.

Degree: Health and Caring Sciences, 2011, Linnaeus University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-12035

► Bakgrund: Då en anhörig insjuknar drabbas makan eller maken av sorg och en känsla av maktlöshet. Att kunna vårda och hjälpa sina nära och… (more)

Subjects/Keywords: Alzheimers sjukdom; Vårdgivare; Makar; Upplevelse; Känslor

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APA (6^th Edition):

Sunnman, J. (2011). Anhörigas upplevelser av att leva med och vårda en person med Alzheimers sjukdom i hemmet : En litteraturstudie. (Thesis). Linnaeus University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-12035

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sunnman, Jenny. “Anhörigas upplevelser av att leva med och vårda en person med Alzheimers sjukdom i hemmet : En litteraturstudie.” 2011. Thesis, Linnaeus University. Accessed March 09, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-12035.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sunnman, Jenny. “Anhörigas upplevelser av att leva med och vårda en person med Alzheimers sjukdom i hemmet : En litteraturstudie.” 2011. Web. 09 Mar 2021.

Vancouver:

Sunnman J. Anhörigas upplevelser av att leva med och vårda en person med Alzheimers sjukdom i hemmet : En litteraturstudie. [Internet] [Thesis]. Linnaeus University; 2011. [cited 2021 Mar 09]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-12035.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sunnman J. Anhörigas upplevelser av att leva med och vårda en person med Alzheimers sjukdom i hemmet : En litteraturstudie. [Thesis]. Linnaeus University; 2011. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-12035

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

19. Nyström, Christer. Alzheimers sjukdom : en förståelseinriktad studie av vardagens svårigheter.

Degree: Nursing, 2002, University West

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:hv:diva-901

Subjects/Keywords: Omvårdnad; Alzheimers sjukdom

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Nyström, C. (2002). Alzheimers sjukdom : en förståelseinriktad studie av vardagens svårigheter. (Thesis). University West. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:hv:diva-901

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Nyström, Christer. “Alzheimers sjukdom : en förståelseinriktad studie av vardagens svårigheter.” 2002. Thesis, University West. Accessed March 09, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:hv:diva-901.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Nyström, Christer. “Alzheimers sjukdom : en förståelseinriktad studie av vardagens svårigheter.” 2002. Web. 09 Mar 2021.

Vancouver:

Nyström C. Alzheimers sjukdom : en förståelseinriktad studie av vardagens svårigheter. [Internet] [Thesis]. University West; 2002. [cited 2021 Mar 09]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:hv:diva-901.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Nyström C. Alzheimers sjukdom : en förståelseinriktad studie av vardagens svårigheter. [Thesis]. University West; 2002. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:hv:diva-901

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Linnaeus University

20. Hed, Ida; Nilsson, Felicia. När insidan försvinner men kroppen finns kvar : Att belysa anhörigvårdares erfarenheter av att leva med en närstående som drabbats av Alzheimers sjukdom.

Degree: Health and Caring Sciences, 2014, Linnaeus University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-39200

► Bakgrund Alzheimers sjukdom kategoriseras vanligtvis som en ”anhörigsjukdom”, begreppet grundar sig i att det är de anhöriga som på lång sikt drabbas hårdast av sjukdomen.… (more)

Subjects/Keywords: Alzheimers sjukdom; familj; erfarenhet; anhörigvårdare; Nursing; Omvårdnad

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APA (6^th Edition):

Hed, Ida; Nilsson, F. (2014). När insidan försvinner men kroppen finns kvar : Att belysa anhörigvårdares erfarenheter av att leva med en närstående som drabbats av Alzheimers sjukdom. (Thesis). Linnaeus University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-39200

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hed, Ida; Nilsson, Felicia. “När insidan försvinner men kroppen finns kvar : Att belysa anhörigvårdares erfarenheter av att leva med en närstående som drabbats av Alzheimers sjukdom.” 2014. Thesis, Linnaeus University. Accessed March 09, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-39200.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hed, Ida; Nilsson, Felicia. “När insidan försvinner men kroppen finns kvar : Att belysa anhörigvårdares erfarenheter av att leva med en närstående som drabbats av Alzheimers sjukdom.” 2014. Web. 09 Mar 2021.

Vancouver:

Hed, Ida; Nilsson F. När insidan försvinner men kroppen finns kvar : Att belysa anhörigvårdares erfarenheter av att leva med en närstående som drabbats av Alzheimers sjukdom. [Internet] [Thesis]. Linnaeus University; 2014. [cited 2021 Mar 09]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-39200.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hed, Ida; Nilsson F. När insidan försvinner men kroppen finns kvar : Att belysa anhörigvårdares erfarenheter av att leva med en närstående som drabbats av Alzheimers sjukdom. [Thesis]. Linnaeus University; 2014. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-39200

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Linnaeus University

21. Hamid, Patryk. Kommunikativa strategier vid omvårdnad av personer med Alzheimers sjukdom.

Degree: Health and Caring Sciences, 2019, Linnaeus University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-80227

► Bakgrund: Alzheimers är en neurodegenerativ sjukdom som påverkar kommunikationen vilket i sin tur försvårar genomförandet av omvårdnad. Det kan därför vara problematiskt att upprätthålla… (more)

Subjects/Keywords: Alzheimers; Kommunikation; Omvårdnad; Sjuksköterskor; Vårdgivare; Nursing; Omvårdnad

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hamid, P. (2019). Kommunikativa strategier vid omvårdnad av personer med Alzheimers sjukdom. (Thesis). Linnaeus University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-80227

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hamid, Patryk. “Kommunikativa strategier vid omvårdnad av personer med Alzheimers sjukdom.” 2019. Thesis, Linnaeus University. Accessed March 09, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-80227.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hamid, Patryk. “Kommunikativa strategier vid omvårdnad av personer med Alzheimers sjukdom.” 2019. Web. 09 Mar 2021.

Vancouver:

Hamid P. Kommunikativa strategier vid omvårdnad av personer med Alzheimers sjukdom. [Internet] [Thesis]. Linnaeus University; 2019. [cited 2021 Mar 09]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-80227.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hamid P. Kommunikativa strategier vid omvårdnad av personer med Alzheimers sjukdom. [Thesis]. Linnaeus University; 2019. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-80227

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Vanderbilt University

22. Dixit, Shilpy. Ascorbate Deficiency Accelerates Neuropathology in Alzheimer's Disease.

Degree: PhD, Neuroscience, 2017, Vanderbilt University

URL: http://hdl.handle.net/1803/14232

► Subclinical ascorbate deficiency is widespread in many populations, but its role in both Alzheimer’s disease and normal aging is understudied. We decreased brain ascorbate in… (more)

▼ Subclinical ascorbate deficiency is widespread in many populations, but its role in both Alzheimer’s disease and normal aging is understudied. We decreased brain ascorbate in the APPSWE/PSEN1deltaE9 mouse model of Alzheimer’s disease by crossing APP/PSEN1+ bigenic mice with SVCT2+/− heterozygous knockout mice, which have lower expression of the sodium-dependent vitamin C transporter required for neuronal ascorbate transport. At 6 months, SVCT2+/− and APP/PSEN1 mice and the combination genotype SVCT2+/−;APP/PSEN1 were impaired on multiple tests of cognitive ability and exhibited increased oxidative stress in the brain. Increased amyloid plaque burden was observed in SVCT2+/−;APP/PSEN1 mice compared to APP/PSEN1 mice at 14 months. At 4 months of age, during what is considered a prodromal stage in mouse models of Alzheimer’s disease, mitochondria isolated from SVCT2+/− and APP/PSEN1 mice showed disruptions in oxygen consumption and mitochondrial respiration with opposing directionality indicating that different pathways were being affected. Both groups had significant increases in the production of reactive oxygen species. Additionally, genes commonly associated with Alzheimer’s disease pathology and progression were up-regulated in SVCT2+/−;APP/PSEN1 mice and APP/PSEN1, with a greater magnitude of gene expression change in SVCT2+/−;APP/PSEN1 mice. Furthermore, 5-hydroxymethylcytosine levels, indicative of epigenetic modification, were significantly increased compared to wild type at 4 months. There were differing patterns of gene expression based on SVCT2+/− and APP/PSEN1 status, as well as with age, suggesting an age-related change in gene expression occurs earlier in APP/PSEN+ groups and is exacerbated in combination with ascorbate deficiency. These data support the hypothesis that even moderate ascorbate deficiency plays an important role in accelerating amyloid pathogenesis, particularly during early stages of disease development, and that oxidative stress pathways likely modulate these effects. Advisors/Committee Members: Aaron Bowman, Ph.D. (committee member), Laura Dugan, M.D. (committee member), James May, M.D. (committee member), Christine Konradi, Ph.D. (Committee Chair).

Subjects/Keywords: Vitamin C; Alzheimers disease; Mitochondria; Gene expression

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dixit, S. (2017). Ascorbate Deficiency Accelerates Neuropathology in Alzheimer's Disease. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/14232

Chicago Manual of Style (16^th Edition):

Dixit, Shilpy. “Ascorbate Deficiency Accelerates Neuropathology in Alzheimer's Disease.” 2017. Doctoral Dissertation, Vanderbilt University. Accessed March 09, 2021. http://hdl.handle.net/1803/14232.

MLA Handbook (7^th Edition):

Dixit, Shilpy. “Ascorbate Deficiency Accelerates Neuropathology in Alzheimer's Disease.” 2017. Web. 09 Mar 2021.

Vancouver:

Dixit S. Ascorbate Deficiency Accelerates Neuropathology in Alzheimer's Disease. [Internet] [Doctoral dissertation]. Vanderbilt University; 2017. [cited 2021 Mar 09]. Available from: http://hdl.handle.net/1803/14232.

Council of Science Editors:

Dixit S. Ascorbate Deficiency Accelerates Neuropathology in Alzheimer's Disease. [Doctoral Dissertation]. Vanderbilt University; 2017. Available from: http://hdl.handle.net/1803/14232

23. Jiang, Sirui. Mitochondrial Dynamic Abnormalities in Alzheimer's Diease.

Degree: PhD, Pathology, 2018, Case Western Reserve University School of Graduate Studies

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1536608714970424

► Alzheimer’s Disease (AD) is the most common cause of dementia leading to progressive memory loss and neurodegeneration in the hippocampus and frontal cortex. While it… (more)

Subjects/Keywords: Pathology; Neurosciences; Alzheimers Disease; Mitochondria; Mitochondrial Dynamics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Jiang, S. (2018). Mitochondrial Dynamic Abnormalities in Alzheimer's Diease. (Doctoral Dissertation). Case Western Reserve University School of Graduate Studies. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1536608714970424

Chicago Manual of Style (16^th Edition):

Jiang, Sirui. “Mitochondrial Dynamic Abnormalities in Alzheimer's Diease.” 2018. Doctoral Dissertation, Case Western Reserve University School of Graduate Studies. Accessed March 09, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1536608714970424.

MLA Handbook (7^th Edition):

Jiang, Sirui. “Mitochondrial Dynamic Abnormalities in Alzheimer's Diease.” 2018. Web. 09 Mar 2021.

Vancouver:

Jiang S. Mitochondrial Dynamic Abnormalities in Alzheimer's Diease. [Internet] [Doctoral dissertation]. Case Western Reserve University School of Graduate Studies; 2018. [cited 2021 Mar 09]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1536608714970424.

Council of Science Editors:

Jiang S. Mitochondrial Dynamic Abnormalities in Alzheimer's Diease. [Doctoral Dissertation]. Case Western Reserve University School of Graduate Studies; 2018. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1536608714970424

Mid Sweden University

24. Staflin, Sara Kron. Anhörigas upplevelser av att vårda personer med Alzheimers sjukdom.

Degree: Health Sciences, 2007, Mid Sweden University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-128

► Bakgrund: Alzheimers sjukdom är den vanligaste bland demenssjukdomar som medför emotionella störningar och personlighetsförändringar. De flesta personer med Alzheimers har en önskan om att… (more)

Subjects/Keywords: Alzheimers sjukdom; Alzheimers; anpassning; familj; vårdarbete

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Staflin, S. K. (2007). Anhörigas upplevelser av att vårda personer med Alzheimers sjukdom. (Thesis). Mid Sweden University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-128

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Staflin, Sara Kron. “Anhörigas upplevelser av att vårda personer med Alzheimers sjukdom.” 2007. Thesis, Mid Sweden University. Accessed March 09, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-128.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Staflin, Sara Kron. “Anhörigas upplevelser av att vårda personer med Alzheimers sjukdom.” 2007. Web. 09 Mar 2021.

Vancouver:

Staflin SK. Anhörigas upplevelser av att vårda personer med Alzheimers sjukdom. [Internet] [Thesis]. Mid Sweden University; 2007. [cited 2021 Mar 09]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-128.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Staflin SK. Anhörigas upplevelser av att vårda personer med Alzheimers sjukdom. [Thesis]. Mid Sweden University; 2007. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-128

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

25. Mayr, Laura. Närståendes upplevelser av att vårda personer med Alzheimers demens : En litteraturöversikt.

Degree: Health Care Sciences, 2019, Ersta Sköndal Bräcke University College

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:esh:diva-7808

►

Bakgrund: Alzheimers demens medför stora kognitiva förändringar i den sjukes liv och beteende och slutar med en grav försämring och förlust av alla kognitiva… (more)

▼

Bakgrund: Alzheimers demens medför stora kognitiva förändringar i den sjukes liv och beteende och slutar med en grav försämring och förlust av alla kognitiva och motoriska funktioner. Detta betyder en stor påfrestning inte bara för den som lider av sjukdomen utan också för närstående som vårdar dessa patienter hemma. Sjuksköterskans ledande och hälsofrämjande roll är då väsentligt för att ge stöd till inte bara för den sjuke men också för dess närstående. Syfte: Syftet var att belysa närståendes upplevelser av att vårda personer med Alzheimers demens. Metod: En litteraturöversikt genomfördes med sökningar i databaserna Academic Search Complete, Cinahl Complete och Nursing & Alliades Health Database. Åtta artiklar valdes efter en kvalitetsgranskning och analysen baserat på likheter och skillnader som efteråt tematiserades. Resultat: Analysen resulterade i tre huvudteman: Vikten av familjerelationer, kultur och traditioner, vilket visade att närstående ger en stor vikt till familjen och ger en inblick av rollen som vårdare och hur de ser på sjukdomen från ett kulturellt perspektiv; bristande familjestöd, vilket visar att närstående kan känna sig övergivna av andra familjemedlemmar och att de inte alltid är villiga att vårda sin sjuke anhörig; strategier för att klara av vardagen, känslor av börda och svårigheter, vilket visar vilka strategier de vårdande närstående använder sig av för att kunna hantera den anhöriges sjukdom och sin egen roll som vårdare. Diskussion: Resultatet diskuterades utifrån Callista Roys teori. Diskussionen fokuserar på hur närstående som vårdar en anhörig med Alzheimers demens upplever en rollförändring och hur de kan återskapa balansen i livet genom att acceptera en föränderlig tillvaro och navigera genom den med hjälp av sjuksköterskans stödjande insatser.

Background: Alzheimer's dementia causes major cognitive changes in the sick's life and behavior and ends with a severe deterioration and loss of all cognitive and motor functions. This means a great stress not only for those who suffer from it but also for relatives who care for them at home. The nurse's leading and health-promoting role is essential for providing support not only for the patient but also for its relatives. Aim: The aim was to illuminate the experiences of relatives in caring for people with Alzheimer's dementia. Method: A literature review was conducted with searches from the databases Academic Search Complete, Cinahl Complete and Nursing & Alliades Health Database. Eight articles were selected after a quality review and the results were analyzed and categorized into main themes. Results: The analysis resulted…

Subjects/Keywords: Alzheimers dementia; relatives; experiences; nurse role; Alzheimers demens; närstående; upplevelse; sjuksköterskans roll; Nursing; Omvårdnad

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mayr, L. (2019). Närståendes upplevelser av att vårda personer med Alzheimers demens : En litteraturöversikt. (Thesis). Ersta Sköndal Bräcke University College. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:esh:diva-7808

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mayr, Laura. “Närståendes upplevelser av att vårda personer med Alzheimers demens : En litteraturöversikt.” 2019. Thesis, Ersta Sköndal Bräcke University College. Accessed March 09, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:esh:diva-7808.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mayr, Laura. “Närståendes upplevelser av att vårda personer med Alzheimers demens : En litteraturöversikt.” 2019. Web. 09 Mar 2021.

Vancouver:

Mayr L. Närståendes upplevelser av att vårda personer med Alzheimers demens : En litteraturöversikt. [Internet] [Thesis]. Ersta Sköndal Bräcke University College; 2019. [cited 2021 Mar 09]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:esh:diva-7808.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mayr L. Närståendes upplevelser av att vårda personer med Alzheimers demens : En litteraturöversikt. [Thesis]. Ersta Sköndal Bräcke University College; 2019. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:esh:diva-7808

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Linnaeus University

26. Johansson, Anna. Alheimers sjukdom och förändrade nivåer av folat, vitamin B12 och homocystein.

Degree: Chemistry and Biomedical Sciences, 2016, Linnaeus University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-52070

►

Bakgrund: Alzheimers sjukdom (AD) utgör vanligaste formen av demenssjukdomar i Sverige. Alzheimers sjukdom klassas som en neurodegenerativ sjukdom och karaktäriseras av proteininlagringar samt av… (more)

▼

Bakgrund: Alzheimers sjukdom (AD) utgör vanligaste formen av demenssjukdomar i Sverige. Alzheimers sjukdom klassas som en neurodegenerativ sjukdom och karaktäriseras av proteininlagringar samt av hjärnatrofi. Ungefär 150 000 personer i Sverige lever idag med demenssjukdomar, varav 90 000 lider av AD och varje år insjuknar ytterligare 20 000 i demens. Vitamin B₁₂ och folat anses utgöra en viktig del med avseende på hjärnans kognitiva funktioner. Låga nivåer av vitamin B₁₂ och/eller folatbrist medför en höjning av Homocystein (Hcy) i blodet. Syfte: Syftet med examensarbetet var att undersöka det eventuella sambandet mellan nivåerna av vitamin B_12, folat respektive Hcy och risken för att drabbas av Alzheimers sjukdom. Utifrån syftet ställdes 2 frågeställningar upp. Frågeställning 1: Finns det en risk att utveckla AD vid förändrade nivåer av folat, vitamin B₁₂och Hcy. Frågeställning 2: Finns det ett samband mellan förändrade nivåer av folat, vitamin B₁₂ och Hcy vid diagnosticerad AD. Metod: Detta arbete är en litteraturstudie baserat på 7 vetenskapliga artiklar. Resultat: Samtliga fem studier utifrån frågeställning 2 visade att AD-patienter hade höga nivåer av Hcy än kontrollpatienterna. Två av dessa studier visade även att AD-patienterna hade lägre nivåer av både vitamin B₁₂och folat än kontrollindividerna. Två ytterligare studier av de fem samtliga visade också lägre nivåer av folat än kontrollgruppen. Totalt 4 av 5 studier visade lägre nivåer av folat. Utifrån frågeställning 1 visade studie 1 att det var enbart de låga nivåerna av folat från baslinjen som förespråkade till insjuknande i AD. Studie 2 indikerade att individer med låga nivåer av vitamin B₁₂och folat har 2 gånger högre risk för att insjukna i AD. Slutsats: Det är fortfarande oklart idag huruvida nivåerna av vitamin B_12,folat och Hcy påverkar riskerna för att utveckla AD. Studierna visar att det finns ett samband mellan markörerna kopplat till AD. Det krävs mer forskning för att fastställa det eventuella sambandet mellan vitamin B_12,folat och Hcy. Fler patienter måste undersökas och flera studier bör utföras för att kunna fastställa associationerna av dessa ämnen med AD. Studierna visar att det finns ett samband mellan markörerna kopplat till AD. Fler studier som tar hänsyn till inklusionskriterierna med avseende på nutritionsstatus bör göras. Detta eftersom lågt BMI (Body Mass Index) kan vara av betydelse för uppkomsten samt riskerna för att insjukna i AD.

Background: Alzheimer's disease (AD) is the most common form of dementia in Sweden. Alzheimer's disease is classified as a neurodegenerative disease and is characterized by protein deposits in certain parts of the brain accompanied with brain atrophy. 150 000 people in Sweden today suffer from dementia, of whom 90 000 suffer from AD and every year another 20 000 dementia cases reside.…

Subjects/Keywords: Alzheimers disease; folate; vitamin B12; homocystein; Alzheimers sjukdom; folat; vitamin B12; homocystein; Pharmaceutical Sciences; Farmaceutiska vetenskaper

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Johansson, A. (2016). Alheimers sjukdom och förändrade nivåer av folat, vitamin B12 och homocystein. (Thesis). Linnaeus University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-52070

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Johansson, Anna. “Alheimers sjukdom och förändrade nivåer av folat, vitamin B12 och homocystein.” 2016. Thesis, Linnaeus University. Accessed March 09, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-52070.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Johansson, Anna. “Alheimers sjukdom och förändrade nivåer av folat, vitamin B12 och homocystein.” 2016. Web. 09 Mar 2021.

Vancouver:

Johansson A. Alheimers sjukdom och förändrade nivåer av folat, vitamin B12 och homocystein. [Internet] [Thesis]. Linnaeus University; 2016. [cited 2021 Mar 09]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-52070.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Johansson A. Alheimers sjukdom och förändrade nivåer av folat, vitamin B12 och homocystein. [Thesis]. Linnaeus University; 2016. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-52070

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Florida

27. Khare, Swati. Understanding the Protective Mechanisms of Two Engineered Anti-Amyloid-Beta Agents in Drosophila.

Degree: MS, Biomedical Engineering, 2013, University of Florida

URL: https://ufdc.ufl.edu/UFE0045618

► Alzheimers disease (AD) is a progressive neurodegenerative disease with no current cure,affecting one in eight Americans above the age of 65 years. Symptomatic treatments with… (more)

Subjects/Keywords: Alzheimers disease; Amyloids; Animal models; Antibodies; Diseases; Drosophila; Medical treatment; Pathology; Phenotypes; Quantification; alzheimers – amyloid – hsp70 – scfv

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Khare, S. (2013). Understanding the Protective Mechanisms of Two Engineered Anti-Amyloid-Beta Agents in Drosophila. (Masters Thesis). University of Florida. Retrieved from https://ufdc.ufl.edu/UFE0045618

Chicago Manual of Style (16^th Edition):

Khare, Swati. “Understanding the Protective Mechanisms of Two Engineered Anti-Amyloid-Beta Agents in Drosophila.” 2013. Masters Thesis, University of Florida. Accessed March 09, 2021. https://ufdc.ufl.edu/UFE0045618.

MLA Handbook (7^th Edition):

Khare, Swati. “Understanding the Protective Mechanisms of Two Engineered Anti-Amyloid-Beta Agents in Drosophila.” 2013. Web. 09 Mar 2021.

Vancouver:

Khare S. Understanding the Protective Mechanisms of Two Engineered Anti-Amyloid-Beta Agents in Drosophila. [Internet] [Masters thesis]. University of Florida; 2013. [cited 2021 Mar 09]. Available from: https://ufdc.ufl.edu/UFE0045618.

Council of Science Editors:

Khare S. Understanding the Protective Mechanisms of Two Engineered Anti-Amyloid-Beta Agents in Drosophila. [Masters Thesis]. University of Florida; 2013. Available from: https://ufdc.ufl.edu/UFE0045618

University of Florida

28. Mathur, Krishanu. Anti-Amyloid Beta scFvs Ameliorate Amyloid Beta-Induced Neurotoxicity in Drosophila.

Degree: MS, Biomedical Engineering, 2013, University of Florida

URL: https://ufdc.ufl.edu/UFE0045610

► Alzheimer’s disease (AD) is a debilitatingneurodegenerative disorder characterized by the presence of amyloid plaques andneurofibrillary tangles. With no known cure at present, investigations intodifferent therapeutic… (more)

Subjects/Keywords: Alzheimers disease; Amyloids; Animal models; Antibodies; Drosophila; Gene therapy; Medical treatment; Phenotypes; Software applications; Solar fibrils; alzheimers – drosophila – neurodegeneration – scfv

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mathur, K. (2013). Anti-Amyloid Beta scFvs Ameliorate Amyloid Beta-Induced Neurotoxicity in Drosophila. (Masters Thesis). University of Florida. Retrieved from https://ufdc.ufl.edu/UFE0045610

Chicago Manual of Style (16^th Edition):

Mathur, Krishanu. “Anti-Amyloid Beta scFvs Ameliorate Amyloid Beta-Induced Neurotoxicity in Drosophila.” 2013. Masters Thesis, University of Florida. Accessed March 09, 2021. https://ufdc.ufl.edu/UFE0045610.

MLA Handbook (7^th Edition):

Mathur, Krishanu. “Anti-Amyloid Beta scFvs Ameliorate Amyloid Beta-Induced Neurotoxicity in Drosophila.” 2013. Web. 09 Mar 2021.

Vancouver:

Mathur K. Anti-Amyloid Beta scFvs Ameliorate Amyloid Beta-Induced Neurotoxicity in Drosophila. [Internet] [Masters thesis]. University of Florida; 2013. [cited 2021 Mar 09]. Available from: https://ufdc.ufl.edu/UFE0045610.

Council of Science Editors:

Mathur K. Anti-Amyloid Beta scFvs Ameliorate Amyloid Beta-Induced Neurotoxicity in Drosophila. [Masters Thesis]. University of Florida; 2013. Available from: https://ufdc.ufl.edu/UFE0045610

The Ohio State University

29. Klee, Victoria H. An Exploration of Genetic Counselors’ Practice Patterns Towards Alzheimer’s Disease in Non-Neurology Clinics.

Degree: MS, Genetic Counseling, 2020, The Ohio State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1586969389732165

► Background: Alzheimer’s Disease (AD) is a neurodegenerative disorder and constitutes the most common type of dementia. The genetics of AD includes autosomal dominant highly penetrant… (more)

▼ Background: Alzheimer’s Disease (AD) is a neurodegenerative disorder and constitutes the most common type of dementia. The genetics of AD includes autosomal dominant highly penetrant variants leading to early onset AD, risk alleles which contribute to risk for late onset AD, and other multifactorial inheritance risk factors. In 2011, the National Society of Genetic Counselors (NSGC) and the American College of Medical Genetics (ACMG) published Joint Practice Guidelines for Genetic Counseling and Testing for Alzheimer Disease which establish a framework for genetic counseling and testing for a personal or family history of AD. Given the prevalence of Alzheimer’s disease in the general population, genetic counselors are likely to encounter family histories of AD outside of neurology practice. Yet, there is little information known about how counselors in non-neurology settings, (e.g. cancer, prenatal, or pediatric sub-specialties) are actually addressing AD when it presents in their clinical practice. The aim of this study was to address this gap in the literature by ascertaining practice patterns related to AD among non-neurology genetic counselors. Methods: American Board of Genetic Counseling (ABGC)-board certified genetic counselors who provided genetic counseling services within the last year in non-neurology clinical practice were recruited to participant in an anonymous Qualtrics© survey. This survey consisted of 32 multiple-choice questions, which ascertained demographic information, AD practice patterns, and survey participants responses to five pedigrees depicting hypothetical AD family history scenarios. The five pedigree scenarios included a family history of early-onset AD (EOAD) with no known AD-associated pathogenic variant, familial late-onset AD (LOAD), sporadic AD, family history of a known APOE e4 allele homozygote, and a known PSEN1 gene pathogenic variant. Descriptive statistics was utilized for statistical analysis.Results: Seventy-three respondents met inclusion criteria and completed the study questionnaire. Thirty-four percent of participants (25/73) reported their primary clinical practice as cancer, 32% (23/73) practiced in the prenatal setting, and the remaining 34% (25/73) practiced in another specialty. Only 46% (34/73) of respondents had an ABGC-board certified genetic counselor, either internal to or outside of their respective institution, whom they could refer a client to for AD genetic counseling. Half of the survey respondents (50%, 37/73) endorsed recording a family history between 6 and 10 times per week and 85% (62/73) of respondents reported they identified a family history of AD approximately 1 to 5 times per week. Among the participants who endorsed uncovering a family history of AD, only 41% (27/66) reported they “often” ask the age of onset. Participants were asked selected the most common factors that they perceive as impacting a patient’s interest in their own family history of AD, factors influencing whether or not they address a family history of AD when it appears, and… Advisors/Committee Members: Allain, Dawn (Advisor).

Subjects/Keywords: Genetics; Alzheimers Disease; genetic testing; genetic counseling; Alzheimers genetics; pedigree scenarios; practice patterns; APOE; PSEN1; PSEN2

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Klee, V. H. (2020). An Exploration of Genetic Counselors’ Practice Patterns Towards Alzheimer’s Disease in Non-Neurology Clinics. (Masters Thesis). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1586969389732165

Chicago Manual of Style (16^th Edition):

Klee, Victoria H. “An Exploration of Genetic Counselors’ Practice Patterns Towards Alzheimer’s Disease in Non-Neurology Clinics.” 2020. Masters Thesis, The Ohio State University. Accessed March 09, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu1586969389732165.

MLA Handbook (7^th Edition):

Klee, Victoria H. “An Exploration of Genetic Counselors’ Practice Patterns Towards Alzheimer’s Disease in Non-Neurology Clinics.” 2020. Web. 09 Mar 2021.

Vancouver:

Klee VH. An Exploration of Genetic Counselors’ Practice Patterns Towards Alzheimer’s Disease in Non-Neurology Clinics. [Internet] [Masters thesis]. The Ohio State University; 2020. [cited 2021 Mar 09]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1586969389732165.

Council of Science Editors:

Klee VH. An Exploration of Genetic Counselors’ Practice Patterns Towards Alzheimer’s Disease in Non-Neurology Clinics. [Masters Thesis]. The Ohio State University; 2020. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1586969389732165

UCLA

30. Tabatabaie-Raissi, Omid. Molecular Dynamics Study of Fragmentation in Protofilaments of Amyloid Beta (16-42).

Degree: Chemical Engineering, 2013, UCLA

URL: http://www.escholarship.org/uc/item/88q2w5j1

► Through the use of molecular dynamics simulations, we show that fragmentation of amyloid beta (16-42) protofilaments occurs through the formation of water-conducting glycine vents surrounding… (more)

Subjects/Keywords: Chemical engineering; alzheimers; amyloid; beta; dynamics; molecular; simulation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tabatabaie-Raissi, O. (2013). Molecular Dynamics Study of Fragmentation in Protofilaments of Amyloid Beta (16-42). (Thesis). UCLA. Retrieved from http://www.escholarship.org/uc/item/88q2w5j1

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tabatabaie-Raissi, Omid. “Molecular Dynamics Study of Fragmentation in Protofilaments of Amyloid Beta (16-42).” 2013. Thesis, UCLA. Accessed March 09, 2021. http://www.escholarship.org/uc/item/88q2w5j1.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tabatabaie-Raissi, Omid. “Molecular Dynamics Study of Fragmentation in Protofilaments of Amyloid Beta (16-42).” 2013. Web. 09 Mar 2021.

Vancouver:

Tabatabaie-Raissi O. Molecular Dynamics Study of Fragmentation in Protofilaments of Amyloid Beta (16-42). [Internet] [Thesis]. UCLA; 2013. [cited 2021 Mar 09]. Available from: http://www.escholarship.org/uc/item/88q2w5j1.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tabatabaie-Raissi O. Molecular Dynamics Study of Fragmentation in Protofilaments of Amyloid Beta (16-42). [Thesis]. UCLA; 2013. Available from: http://www.escholarship.org/uc/item/88q2w5j1

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Open Access Theses and Dissertations