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Freie Universität Berlin

1. Wolfram, Julia. Influence of a prophylactic factor XIII application to alcohol dependent patients undergoing a neck dissection on the perioperative blood loss and the amount of blood transfusions.

Degree: 2018, Freie Universität Berlin

Background: The acquired factor XIII deficiency after major operations is correlated with perioperative blood loss and bleeding disorders. This study investigated the effect of a prophylactic factor XIII application on the perioperative blood loss and the rate of blood transfusions for alcohol dependent patients undergoing a neck dissection. Methods: In this prospective double-blind clinical study 23 alcohol dependent patients with a carcinoma, an elective neck dissection and a daily minimum consumption of 60 g of alcohol were randomized into two groups. The Fibrogammin group (n=11) was treated with 2500 U Fibrogammin® preoperatively and four times 1250 U postoperatively. The placebo group (n=12) received 0.9 % saline solution instead. The blood loss and transfused blood products were measured intraoperatively and daily up to 10 days after surgery or until the discharge from hospital. Results: In between Fibrogammin and placebo group there was no significant difference of blood loss according to the multivariate testing method (p=0.59) as well as the univariate testing method (intraoperative p=0.83; postoperative p=0.74; perioperative p=0.88). A tendency of decreased bleeding was found at 1. POD (1. POD: p=0.24). Intraoperative blood products were administered to 1 patient in the Fibrogammin (1 EK and 2 FFP) and 2 patients from the placebo group (3 EK respectively 2 EK). 1 patient in each group received a transfusion postoperatively (Fibrogammin group: 1 EK, placebo group: 3 EK). The need of transfusions did not differ within the groups (p=1.00). The length of hospital stay in the Fibrogammin group tended to be 2 days shorter (p=0.41). After the neck dissection, the factor XIII levels within the placebo group decreased significantly by 30 %. 40 % of patients from the placebo group developed an acquired factor XIII deficiency (≤ 70 %). The patients with an acquired factor XIII deficiency showed a significantly enhanced blood loss intraoperatively and at the 2nd POD (intraop: p=0.02; 2. POD: p=0.02). In the Fibrogammin group, the value remained within the range of reference. Conclusions: Within both groups the results did not show a significant reduction of perioperative blood loss or decreased need for blood transfusions after the prophylactic application of factor XIII. However, the descriptive results indicate that the detection of factor XIII levels and the selective application of factor XIII can be beneficial for alcohol-dependent patients with a high perioperative blood loss. Advisors/Committee Members: w (gender), N. N. (firstReferee), N. N. (furtherReferee).

Subjects/Keywords: factor XIII; neck dissection; alcohol dependent patients; blood loss; blood transfusion; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA (6th Edition):

Wolfram, J. (2018). Influence of a prophylactic factor XIII application to alcohol dependent patients undergoing a neck dissection on the perioperative blood loss and the amount of blood transfusions. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-10286

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Wolfram, Julia. “Influence of a prophylactic factor XIII application to alcohol dependent patients undergoing a neck dissection on the perioperative blood loss and the amount of blood transfusions.” 2018. Thesis, Freie Universität Berlin. Accessed October 30, 2020. http://dx.doi.org/10.17169/refubium-10286.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Wolfram, Julia. “Influence of a prophylactic factor XIII application to alcohol dependent patients undergoing a neck dissection on the perioperative blood loss and the amount of blood transfusions.” 2018. Web. 30 Oct 2020.

Vancouver:

Wolfram J. Influence of a prophylactic factor XIII application to alcohol dependent patients undergoing a neck dissection on the perioperative blood loss and the amount of blood transfusions. [Internet] [Thesis]. Freie Universität Berlin; 2018. [cited 2020 Oct 30]. Available from: http://dx.doi.org/10.17169/refubium-10286.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wolfram J. Influence of a prophylactic factor XIII application to alcohol dependent patients undergoing a neck dissection on the perioperative blood loss and the amount of blood transfusions. [Thesis]. Freie Universität Berlin; 2018. Available from: http://dx.doi.org/10.17169/refubium-10286

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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