subject:(agents)

1. Okdah, Liliane. Gestion patrimoniale des anciens agents antimicrobiens en les criblant contre des bactéries multi-résistantes modernes : Patrimonial management of old antimicrobial agents by screening against modern multi-drug resistants bacteria.

Degree: Docteur es, Pathologie humaine. Maladies infectieuses, 2017, Aix Marseille Université

URL: http://www.theses.fr/2017AIXM0593

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L’émergence des bactéries résistantes aux béta-lactamines et aux carbapénèmes, a abouti à la réintroduction de la colistine comme agent de dernier recours pour traiter les… (more)

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L’émergence des bactéries résistantes aux béta-lactamines et aux carbapénèmes, a abouti à la réintroduction de la colistine comme agent de dernier recours pour traiter les infections dues à ces germes. Cependant, les résistances chromosomique et plus récemment plasmidique à la colistine ont apparu. Ce problème de bactéries multi-résistantes a par la suite déclenché la publication d’articles alarmants sur les dangers de ces germes. Pour répondre à la dramatisation médiatique liée à ce problème, mon projet de thèse vise à proposer des stratégies thérapeutiques pour traiter les infections dues aux bactéries multi-résistantes. Dans un premier temps, nous avons testé l’activité d’un large panel comprenant des anciens antibiotiques contre les bactéries résistantes aux carbapénèmes et d’autres résistantes à la colistine. Plusieurs familles d’antibiotiques ont été efficaces contre ces 2 types de bactéries résistantes.Dans un deuxième temps, nous avons évalué l’activité d’antibiotiques combinés en vue de détecter une synergie d’action. Deux combinaisons synergiques ont été retenues : colistine + sulfadiazine et colistine + acide fusidique. Ces associations d’antibiotiques ont démontré un effet bactéricide sur une collection de bactéries Gram négatives résistantes à la colistine, et ceci indépendamment du mécanisme de résistance.

The emergence of beta-lactam and carbapenem resistant bacteria, resulted in the reintroduction of colistin as an agent of last resort to treat infections caused by these bacteria. However, chromosomal resistances and more recently plasmidic to colistin appeared. This problem of multidrug-resistant bacteria subsequently triggered the publication of alarming articles on the dangers of these germs. To answer the media dramatization related to this problem, my thesis project aims to propose therapeutic strategies to treat infections due to multiresistant bacteria.Initially, we tested the activity of a large panel including old antibiotics against carbapenem resistant bacteria and others resistant to colistin. Several families of antibiotics have been effective against these two types of resistant bacteria.In a second step, we evaluated the activity of combined antibiotics in order to detect a synergistic action. Two synergistic combinations were retained: colistin + sulfadiazine and colistin + fusidic acid. These combinations of antibiotics have shown a bactericidal effect on a collection of Gram-negative colistin-resistant bacteria, independent of the resistance mechanism.

Advisors/Committee Members: Rolain, Jean-Marc (thesis director).

Subjects/Keywords: Agents antimicrobiens; Antimicrobial agents

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Okdah, L. (2017). Gestion patrimoniale des anciens agents antimicrobiens en les criblant contre des bactéries multi-résistantes modernes : Patrimonial management of old antimicrobial agents by screening against modern multi-drug resistants bacteria. (Doctoral Dissertation). Aix Marseille Université. Retrieved from http://www.theses.fr/2017AIXM0593

Chicago Manual of Style (16^th Edition):

Okdah, Liliane. “Gestion patrimoniale des anciens agents antimicrobiens en les criblant contre des bactéries multi-résistantes modernes : Patrimonial management of old antimicrobial agents by screening against modern multi-drug resistants bacteria.” 2017. Doctoral Dissertation, Aix Marseille Université. Accessed January 19, 2021. http://www.theses.fr/2017AIXM0593.

MLA Handbook (7^th Edition):

Okdah, Liliane. “Gestion patrimoniale des anciens agents antimicrobiens en les criblant contre des bactéries multi-résistantes modernes : Patrimonial management of old antimicrobial agents by screening against modern multi-drug resistants bacteria.” 2017. Web. 19 Jan 2021.

Vancouver:

Okdah L. Gestion patrimoniale des anciens agents antimicrobiens en les criblant contre des bactéries multi-résistantes modernes : Patrimonial management of old antimicrobial agents by screening against modern multi-drug resistants bacteria. [Internet] [Doctoral dissertation]. Aix Marseille Université 2017. [cited 2021 Jan 19]. Available from: http://www.theses.fr/2017AIXM0593.

Council of Science Editors:

Okdah L. Gestion patrimoniale des anciens agents antimicrobiens en les criblant contre des bactéries multi-résistantes modernes : Patrimonial management of old antimicrobial agents by screening against modern multi-drug resistants bacteria. [Doctoral Dissertation]. Aix Marseille Université 2017. Available from: http://www.theses.fr/2017AIXM0593

2. Cheaib, Nader. Contribution à la malléabilité des collecticiels : une approche basée sur les services web et les agents logiciels : Contribution to groupware tailorability : an approach based on web services and software agents.

Degree: Docteur es, Informatique, 2010, Evry-Val d'Essonne

URL: http://www.theses.fr/2010EVRY0011

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L'objectif du TCAO (Travail Collaboratif Assisté par Ordinateur), est de trouver les moyens par lesquels les applications collaboratives sont susceptibles d'améliorer la collaboration entre les… (more)

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L'objectif du TCAO (Travail Collaboratif Assisté par Ordinateur), est de trouver les moyens par lesquels les applications collaboratives sont susceptibles d'améliorer la collaboration entre les individus. De ce fait, il existe une grande nécessité de remédier des contraintes liées au manque de flexibilité et la rigidité des systèmes collaboratifs actuels, par l'adoption des solutions adéquates pour mettre en oeuvre une meilleure collaboration, selon le contexte et la tâche à effectuer entre les utilisateurs. En effet, le domaine du TCAO doit évoluer avec l'évolution des systèmes et des technologies qui touchent notre vie quotidienne, surtout l'évolution de l'internet qui nous rend totalement dépendant des services et applications qui existent "virtuellement", où la plupart des utilisateurs passent une bonne partie de leurs temps à exploiter des méthodes à rechercher et utiliser ces services qui correspondent le plus à leurs préférences. C'est pour cette raison que l'évolution du TCAO se montre essentielle pour faire face à l'évolution exponentielle des technologies d'internet, afin de créer ou de réutiliser plus facilement des applications chargées d'assister le travail communautaire des hommes, que l'on nomme applications collaboratives, ou collecticiels. Le sujet de thèse proposé couvre les aspects collaboratifs d'un système et les questions concernant son intégration. Plus particulièrement, notre objectif essentiel est de concevoir une architecture logicielle pour les collecticiels malléables, de sorte qu'elle puisse s'adapter aux changements et aux diversités des besoins des utilisateurs, ainsi que la tâche à effectuer. En conséquence, une forte exigence surgit en terme d'ouverture, où le système peut dynamiquement intégrer de nouveaux services sans arrêter le déroulement de la collaboration, ni manuellement recoder et recompiler l'application. Une deuxième exigence est d'assurer une certaine adaptabilité, où le système peut générer de nouveaux comportements à partir de la composition de deux ou plusieurs services. Finalement, une exigence surgit en terme d'interopérabilité, surtout dans le cas où les utilisateurs utilisent des applications incompatibles ou hétérogènes. Ainsi, la création, l'ajout, la suppression ou la manipulation des composants du système collaboratif sont faites via les services web. De plus, la recherche, l'invocation et l'intégration de ces services se fait à l'aide d'agents logiciels qui se chargeront, avec une assistance minimale de l'utilisateur, de rechercher les services les mieux adaptés à leurs spécifications. Dans cette thèse, nous créons un lien entre les concepts théoriques qui se développent au sein des laboratoires de recherche, et les technologies qui se développent d'une façon très rapide dans le secteur industriel, afin de concevoir des systèmes collaboratifs plus adaptés au monde informatique quotidien.

The aim of CSCW (Computer Supported Cooperative Work) is to find ways in which applications should improve collaborative work between individuals. Hence, there is great…

Advisors/Committee Members: Mallem, Malik (thesis director).

Subjects/Keywords: Agents logiciels; Software agents

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cheaib, N. (2010). Contribution à la malléabilité des collecticiels : une approche basée sur les services web et les agents logiciels : Contribution to groupware tailorability : an approach based on web services and software agents. (Doctoral Dissertation). Evry-Val d'Essonne. Retrieved from http://www.theses.fr/2010EVRY0011

Chicago Manual of Style (16^th Edition):

Cheaib, Nader. “Contribution à la malléabilité des collecticiels : une approche basée sur les services web et les agents logiciels : Contribution to groupware tailorability : an approach based on web services and software agents.” 2010. Doctoral Dissertation, Evry-Val d'Essonne. Accessed January 19, 2021. http://www.theses.fr/2010EVRY0011.

MLA Handbook (7^th Edition):

Cheaib, Nader. “Contribution à la malléabilité des collecticiels : une approche basée sur les services web et les agents logiciels : Contribution to groupware tailorability : an approach based on web services and software agents.” 2010. Web. 19 Jan 2021.

Vancouver:

Cheaib N. Contribution à la malléabilité des collecticiels : une approche basée sur les services web et les agents logiciels : Contribution to groupware tailorability : an approach based on web services and software agents. [Internet] [Doctoral dissertation]. Evry-Val d'Essonne; 2010. [cited 2021 Jan 19]. Available from: http://www.theses.fr/2010EVRY0011.

Council of Science Editors:

Cheaib N. Contribution à la malléabilité des collecticiels : une approche basée sur les services web et les agents logiciels : Contribution to groupware tailorability : an approach based on web services and software agents. [Doctoral Dissertation]. Evry-Val d'Essonne; 2010. Available from: http://www.theses.fr/2010EVRY0011

3. White, Jacob Barry. Managing Agent Sampling Probabilities in Irregular Networks.

Degree: 2012, Wake Forest University

URL: http://hdl.handle.net/10339/37297

► Agent-based security can provide a good distributed solution to issues surrounding large real-world networks. Such networks are often modeled by small-world, scale-free, minimum-distance, or random… (more)

Subjects/Keywords: agents

…The set of tasks that could be performed by agents is vast. Agents could be used to monitor… …Additionally, as agents are constantly traversing the network, they can check the status of the links… …agents as well. Since agents are built to move throughout a network, any information that needs… …While agents provide a reasonable solution to many of the issues facing large networks, they… …are not without problems. First, agents may be clustered around specific parts of the…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

White, J. B. (2012). Managing Agent Sampling Probabilities in Irregular Networks. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/37297

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

White, Jacob Barry. “Managing Agent Sampling Probabilities in Irregular Networks.” 2012. Thesis, Wake Forest University. Accessed January 19, 2021. http://hdl.handle.net/10339/37297.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

White, Jacob Barry. “Managing Agent Sampling Probabilities in Irregular Networks.” 2012. Web. 19 Jan 2021.

Vancouver:

White JB. Managing Agent Sampling Probabilities in Irregular Networks. [Internet] [Thesis]. Wake Forest University; 2012. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/10339/37297.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

White JB. Managing Agent Sampling Probabilities in Irregular Networks. [Thesis]. Wake Forest University; 2012. Available from: http://hdl.handle.net/10339/37297

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Wake Forest University

4. Pickard, Amanda Jayne. NOVEL APPROACHES FOR CONTROLLING TARGET SELECTIVITY AND PHARMACOLOGICAL PROPERTIES OF PLATINUM-INTERCALATOR-BASED ANTICANCER AGENTS.

Degree: 2014, Wake Forest University

URL: http://hdl.handle.net/10339/39394

► Traditional DNA-targeted anticancer agents, such as platinum-based therapies, have been a mainstay in the treatment of aggressive solid malignancies in the clinical setting. Unfortunately, due… (more)

Subjects/Keywords: Anticancer agents

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pickard, A. J. (2014). NOVEL APPROACHES FOR CONTROLLING TARGET SELECTIVITY AND PHARMACOLOGICAL PROPERTIES OF PLATINUM-INTERCALATOR-BASED ANTICANCER AGENTS. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/39394

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Pickard, Amanda Jayne. “NOVEL APPROACHES FOR CONTROLLING TARGET SELECTIVITY AND PHARMACOLOGICAL PROPERTIES OF PLATINUM-INTERCALATOR-BASED ANTICANCER AGENTS.” 2014. Thesis, Wake Forest University. Accessed January 19, 2021. http://hdl.handle.net/10339/39394.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Pickard, Amanda Jayne. “NOVEL APPROACHES FOR CONTROLLING TARGET SELECTIVITY AND PHARMACOLOGICAL PROPERTIES OF PLATINUM-INTERCALATOR-BASED ANTICANCER AGENTS.” 2014. Web. 19 Jan 2021.

Vancouver:

Pickard AJ. NOVEL APPROACHES FOR CONTROLLING TARGET SELECTIVITY AND PHARMACOLOGICAL PROPERTIES OF PLATINUM-INTERCALATOR-BASED ANTICANCER AGENTS. [Internet] [Thesis]. Wake Forest University; 2014. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/10339/39394.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pickard AJ. NOVEL APPROACHES FOR CONTROLLING TARGET SELECTIVITY AND PHARMACOLOGICAL PROPERTIES OF PLATINUM-INTERCALATOR-BASED ANTICANCER AGENTS. [Thesis]. Wake Forest University; 2014. Available from: http://hdl.handle.net/10339/39394

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Baylor University

5. George, Clinton S. Targeting the tumor microenvironment through the design and synthesis of potent, small-molecule, anticancer agents.

Degree: PhD, Chemistry and Biochemistry., 2012, Baylor University

URL: http://hdl.handle.net/2104/8482

► Targeting the vascular network that supplies a tumor with oxygen and nutrients is a viable methodology for the treatment of cancer. With the discovery of… (more)

▼ Targeting the vascular network that supplies a tumor with oxygen and nutrients is a viable methodology for the treatment of cancer. With the discovery of the combretastatin extended family of compounds in the late 1970's and early 80's, there has been an accelerated interest in vascular targeting as a possible cancer treatment methodology. Two natural products, combretastatin A-1 (CA1) and combretastatin A-4 (CA4) interfere with the tubulin-microtubule protein system in the endothelial cells lining tumor vasculature, ultimately resulting in vessel damage. A new class of compounds shares similar functional group motifs and structural orientations to CA4, but is based on a benzosuberene core structure. These benzosuberene analogues incorporate a [6,7] fused ring system with an aryl ring attached at the 5-position. The initial discovery in the Pinney Research Group of the benzosuberene lead compound 1-hydroxy-2-methoxy-5-(3',4',5'-trimethoxyphenyl)benzocyclohept-5-ene 1, has led to research focused on the development of an efficient strategy for synthesizing [6,7] fused ring systems and the preparation of new, diversely functionalized benzosuberene analogues. New derivatives include regioisomeric incorporations of methoxy and hydroxy groups, along with the inclusion of nitro, amine, and halogen substituents. Bioreductively activated prodrug triggers, as well as [6,8] and [5,7] fused ring systems are also included in the library of compounds developed. Initial biological evaluation of these benzosuberene compounds provide interesting results. These compounds were evaluated for cytotoxicity against three human cancer cell lines, and for their ability to inhibit the assembly of tubulin into microtubules. Among the library of compounds screened, several analogues were discovered that are comparable in activity to CA4 and CA1. For example, 1,2-dihydroxy-5-(3',4',5'-trimethoxyphenyl)-benzosuber-5-ene 20 and 1,2-dimethoxy-5-(3',4',5'-trimethoxyphenyl)-benzosuber-5-ene 22 are strongly cytotoxic against the NCI-H460 human cell line (GI50 = 0.410 and 0.479 μM respectively). Collectively, the structure-activity relationship (SAR) knowledge gained from these compounds will guide the design of new benzosuberene-based anticancer agents. Advisors/Committee Members: Pinney, Kevin G. (advisor).

Subjects/Keywords: Anticancer agents.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

George, C. S. (2012). Targeting the tumor microenvironment through the design and synthesis of potent, small-molecule, anticancer agents. (Doctoral Dissertation). Baylor University. Retrieved from http://hdl.handle.net/2104/8482

Chicago Manual of Style (16^th Edition):

George, Clinton S. “Targeting the tumor microenvironment through the design and synthesis of potent, small-molecule, anticancer agents.” 2012. Doctoral Dissertation, Baylor University. Accessed January 19, 2021. http://hdl.handle.net/2104/8482.

MLA Handbook (7^th Edition):

George, Clinton S. “Targeting the tumor microenvironment through the design and synthesis of potent, small-molecule, anticancer agents.” 2012. Web. 19 Jan 2021.

Vancouver:

George CS. Targeting the tumor microenvironment through the design and synthesis of potent, small-molecule, anticancer agents. [Internet] [Doctoral dissertation]. Baylor University; 2012. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2104/8482.

Council of Science Editors:

George CS. Targeting the tumor microenvironment through the design and synthesis of potent, small-molecule, anticancer agents. [Doctoral Dissertation]. Baylor University; 2012. Available from: http://hdl.handle.net/2104/8482

Nelson Mandela Metropolitan University

6. Pringle, Nadine Alex. Comprehensive characterization of the antidiabetic potential of selected plants and macrofungi from Africa using an in vitro target-directed screening platform and cellomics.

Degree: 2020, Nelson Mandela Metropolitan University

URL: http://hdl.handle.net/10948/46750

► Several synthetic antidiabetic drugs have been developed to date, however, most are accompanied by adverse side-effects while remaining expensive and largely inaccessible to the vast… (more)

▼ Several synthetic antidiabetic drugs have been developed to date, however, most are accompanied by adverse side-effects while remaining expensive and largely inaccessible to the vast majority of those who need it. To provide enough scientific evidence to support the inclusion of more affordable African antidiabetic medicinal plants and macrofungi into healthcare programs, this study sought out to develop a comprehensive in vitro antidiabetic target-directed screening platform incorporating high content screening and analysis/ cellomics. To test the success of this model, the potential antidiabetic mechanisms of five plants (Aspalathus linearis, Brachylaena discolor, Carpobrotus deliciosus, Sutherlandia frutescens and Tarchonanthus camphoratus) and two macrofungal species (Ganoderma lucidum and Hericium erinaceus) were explored. The screening model consisted of approximately 22 assays exploring the antidiabetic effects of selected aqueous and ethanolic extracts in five well-characterised antidiabetic targets: the intestine, liver, skeletal muscle, adipose tissue/ obesity and pancreatic β-cells. These targets were further categorised and scored under three mechanistic classes/ therapeutic targets (postprandial hyperglycaemia; insulin resistance and inflammation; pancreatic β-cell function) to elucidate their potential mechanisms of action and select appropriate animal models for future studies. Almost any normal or diabetic rodent model would be suitable to explore the antidiabetic potential of extracts such as A. linearis, B. discolor ethanol, C. deliciosus ethanol or T. camphoratus which obtained high cumulative scores under postprandial hyperglycaemia while high fat diet and genetic models of obesity appear more suited towards extracts such as H. erinaceus aqueous that obtained their highest cumulative score under insulin resistance. In general, a combination of rodent models ranging from non-obese models to models of obesity and β-cell destruction presenting symptoms from all three mechanistic classes should be considered due to the pleiotropic nature of the tested extracts, however, establishing appropriate experimental designs is crucial. To demonstrate the versatility of the screening platform and emphasise the importance of in vitro screening pertaining to diabetic complications, a more detailed biochemical investigation into the potential therapeutic benefits of A. linearis in the treatment of diabetic wounds was conducted. Several properties supporting the therapeutic potential of rooibos were highlighted with the green and fermented extracts presenting distinctly different characteristics. The pro-inflammatory nature of fermented rooibos may have therapeutic value for wounds characterised with a delayed initial inflammatory phase, such as early diabetic wounds while the green extract appears more suited to wounds burdened with excessive inflammation as it attenuated COX-2 levels and effectively protected fibroblasts against oxidative stress. To date, this appears to be the most comprehensive antidiabetic…

Subjects/Keywords: Hypoglycemic agents

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pringle, N. A. (2020). Comprehensive characterization of the antidiabetic potential of selected plants and macrofungi from Africa using an in vitro target-directed screening platform and cellomics. (Thesis). Nelson Mandela Metropolitan University. Retrieved from http://hdl.handle.net/10948/46750

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Pringle, Nadine Alex. “Comprehensive characterization of the antidiabetic potential of selected plants and macrofungi from Africa using an in vitro target-directed screening platform and cellomics.” 2020. Thesis, Nelson Mandela Metropolitan University. Accessed January 19, 2021. http://hdl.handle.net/10948/46750.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Pringle, Nadine Alex. “Comprehensive characterization of the antidiabetic potential of selected plants and macrofungi from Africa using an in vitro target-directed screening platform and cellomics.” 2020. Web. 19 Jan 2021.

Vancouver:

Pringle NA. Comprehensive characterization of the antidiabetic potential of selected plants and macrofungi from Africa using an in vitro target-directed screening platform and cellomics. [Internet] [Thesis]. Nelson Mandela Metropolitan University; 2020. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/10948/46750.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pringle NA. Comprehensive characterization of the antidiabetic potential of selected plants and macrofungi from Africa using an in vitro target-directed screening platform and cellomics. [Thesis]. Nelson Mandela Metropolitan University; 2020. Available from: http://hdl.handle.net/10948/46750

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Southern California

7. Lee, Jina. Modeling nonverbal behaviors for virtual agents.

Degree: PhD, Computer Science, 2012, University of Southern California

URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/199967/rec/4141

► Virtual agents are autonomous software characters that support face-to-face interactions with human users. They are capable of understanding human input (i.e. speech, text input) and… (more)

▼ Virtual agents are autonomous software characters that support face-to-face interactions with human users. They are capable of understanding human input (i.e. speech, text input) and automatically generating responses that are adaptive to the context of the interaction. By communicating through verbal and nonverbal channels (i.e. behaviors without words), virtual agents can support meaningful social interactions with human users. ❧ One of the main goals in virtual agent research is to emulate how humans interact face-to-face. While traditional human-agent interaction was mainly accomplished through speech or text, with the emergence of better graphical representation and control over the virtual agent's embodiment, communication through nonverbal behaviors has become an active research area. However, nonverbal behavior is complex, involving many different behaviors, such as facial expressions, arm gestures, and gaze movements. There is also a complex mapping between nonverbal behaviors and their impact on communication (the communicative functions) and this creates a great challenge in the task of behavior authoring for virtual agents. ❧ The central goal of this research is to explore ways to derive models that automatically generate nonverbal behaviors and can thereby greatly facilitate behavior authoring. In this research, two major approaches to provide computational frameworks for generating nonverbal behaviors are explored: a literature-based approach and a machine learning approach. The former approach encodes the findings of psychological research into a set of rules, which is validated and prioritized through additional video analysis. The framework developed from this work has been incorporated within a growing number of different virtual agent systems. The machine learning approach focuses on learning the patterns of speaker behaviors, including head nods and eyebrow movements, as well as the behaviors of people with different characteristics (i.e. different job roles and behavioral traits). The objective evaluations show that the probabilistic models learned on a subgroup of people achieved better learning performance and the subjective evaluation study shows that the characteristics of the subgroups of people learned by the models can be carried through their generated behaviors. ❧ This research contributes to the development of virtual agents by facilitating the behavior authoring process, providing comparisons of different approaches for modeling nonverbal behaviors that has not been studied extensively before, and understanding the discrepancies between the behavior modeling process and the perception of the behaviors through evaluation studies with human subjects. Advisors/Committee Members: Marsella, Stacy C. (Committee Chair), Gratch, Jonathan (Committee Member), Read, Stephen J. (Committee Member), Tambe, Milind (Committee Member).

Subjects/Keywords: nonverbal behavior; virtual agents; embodied conversational agents

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lee, J. (2012). Modeling nonverbal behaviors for virtual agents. (Doctoral Dissertation). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/199967/rec/4141

Chicago Manual of Style (16^th Edition):

Lee, Jina. “Modeling nonverbal behaviors for virtual agents.” 2012. Doctoral Dissertation, University of Southern California. Accessed January 19, 2021. http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/199967/rec/4141.

MLA Handbook (7^th Edition):

Lee, Jina. “Modeling nonverbal behaviors for virtual agents.” 2012. Web. 19 Jan 2021.

Vancouver:

Lee J. Modeling nonverbal behaviors for virtual agents. [Internet] [Doctoral dissertation]. University of Southern California; 2012. [cited 2021 Jan 19]. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/199967/rec/4141.

Council of Science Editors:

Lee J. Modeling nonverbal behaviors for virtual agents. [Doctoral Dissertation]. University of Southern California; 2012. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/199967/rec/4141

University of Zambia

8. Mweene, Morgan Dimakweenda. A study to investigate factors associated with poor adherence to antihypertensive population, at the University Teaching Hospital Lusaka, Zambia .

Degree: 2012, University of Zambia

URL: http://hdl.handle.net/123456789/979

► To determine the prevalence of drug adherence and factors associated with poor adherence to antihypertensive treatment Objective:among adults seen in the department of medicine at… (more)

▼ To determine the prevalence of drug adherence and factors associated with poor adherence to antihypertensive treatment Objective:among adults seen in the department of medicine at UTH. To investigate patient related and health care system related factors associated with poor adherence to antihypertensive Drugs.Methods:Adult patients aged 18 and above with previous diagnosis of essential hypertension receiving outpatient care in the UTH medical clinics were recruited from the first week of November to the second week of December 2010. Data was collected from patients regarding patients‘ social demographic factors, level of education, income per month and family history of hypertension. Information was also collected regarding health care system related factors and care giver related factors to patient non adherence using self report and modified hill bone compliance scale.Data was collected from 234 participants. The mean age was 57.8 ± 12.0 SD. 51 patients (22%) had diabetes mellitus and 44 patients (19%) had the diagnosis of heart failure. The commonest side effects of drugs reported in the study were dizziness and excessive urination, affecting 35% and 31% of patients, respectively. Patients on three antihypertensive drugs were less likely to be non-adherent (odds ratio 0.21, 95% CI 0.06-0.79) than patients taking only one drug.Majority (60%) of the patients were reviewed at least twice in the last 6 months at the time of the interview. 195 (83%) patients reported that drugs prescribed were not available at the hospital pharmacy, but 186 (79%) of these were able to purchase the drugs elsewhere.221 patients (94%) were counseled by the doctor on how to take medicines. Patients counseled by the nurse were more likely to be adherent than those not counseled by the nurse, OR 2.7 (1.0-7.3). Those who were counseled for more than 5 minutes had significantly less non-adherence as reported by both self report and modified Hill Bone with OR of 0.3(95% CI 0.2-0.8) and 0.3(95% CI0.1-0.5), respectively.In multivariable analysis, participants were more likely to be non-adherent by self-report if they had attained a primary level of education, had missed appointments due to lack of transport, or had experienced the side effect of dizziness. Patients with heart failure were more likely to be non-adherent based on the modified Hill-Bone scale, whereas those taking 3 antihypertensive drugs and those who were counseled for more than 5 minutes on drugs were significantly less likely to be non-adherent.Conclusion:The prevalence of adherence among hypertensive patients was found to be higher than anticipated. The factors associated with non-adherence included side effect of dizziness, missed appointment due to lack of transport, and living at a distance of more than 10 km from the hospital. Taking 3 BP drugs and receiving more than 5 minutes of counseling about how to take medications were both associated with decreased likelihood of non-adherence. This information provides baseline data to help improve and address the issues of…

Subjects/Keywords: Hypotension; Antihypertensive agents

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APA (6^th Edition):

Mweene, M. D. (2012). A study to investigate factors associated with poor adherence to antihypertensive population, at the University Teaching Hospital Lusaka, Zambia . (Thesis). University of Zambia. Retrieved from http://hdl.handle.net/123456789/979

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mweene, Morgan Dimakweenda. “A study to investigate factors associated with poor adherence to antihypertensive population, at the University Teaching Hospital Lusaka, Zambia .” 2012. Thesis, University of Zambia. Accessed January 19, 2021. http://hdl.handle.net/123456789/979.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mweene, Morgan Dimakweenda. “A study to investigate factors associated with poor adherence to antihypertensive population, at the University Teaching Hospital Lusaka, Zambia .” 2012. Web. 19 Jan 2021.

Vancouver:

Mweene MD. A study to investigate factors associated with poor adherence to antihypertensive population, at the University Teaching Hospital Lusaka, Zambia . [Internet] [Thesis]. University of Zambia; 2012. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/123456789/979.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mweene MD. A study to investigate factors associated with poor adherence to antihypertensive population, at the University Teaching Hospital Lusaka, Zambia . [Thesis]. University of Zambia; 2012. Available from: http://hdl.handle.net/123456789/979

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

9. Achir, Samira. Etude des mécanismes de stabilisation des protéines par spectroscopie Raman et dynamique moléculaire : The protein stabilizing mechanisms investigated by Raman scattering and molecular dynamics simulations.

Degree: Docteur es, Molécules et Matière Condensée, 2014, Université Lille I – Sciences et Technologies

URL: http://www.theses.fr/2014LIL10022

►

Cette thèse est une contribution à l’étude des mécanismes de stabilisation des protéines en solution et à l’état sec. Un nombre considérable de biomolécules thérapeutiques… (more)

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Cette thèse est une contribution à l’étude des mécanismes de stabilisation des protéines en solution et à l’état sec. Un nombre considérable de biomolécules thérapeutiques émanant des avancées de la technologie ADN recombinant sont porteuses de nouvelles approches thérapeutiques, mais ne peuvent pas être utilisées à cause de leur très faible stabilité. Celle-ci est améliorée à l’état sec, après lyophilisation qui est toutefois source de nombreux stress pour la protéine. Les travaux ont principalement focalisé sur l’étude de la stabilité de l’état physique de protéines modèles, par micro-spectroscopie Raman in-situ au cours d’une procédure de lyophilisation. Cette analyse a permis de déterminer les sources et le processus de dénaturation, ainsi que les transformations structurales de la protéine inhérente à la lyophilisation. Des cartographies Raman réalisées aux différentes étapes d’un cycle de lyophilisation, ont conduit à la description des interactions entre protéine, solvant et co-solvant et au décryptage des mécanismes de stabilisation de la protéine pendant l’opération de lyophilisation. La stabilité de l’état physique des protéines, lyophilisées en utilisant différents agents bioprotecteurs, a également été analysée lors de vieillissements accélérés, révélant l’efficacité bioprotectrice du tréhalose, exacerbée par l’ajout d’une faible quantité de glycérol. Des simulations de dynamique moléculaire ont aussi été réalisées sur les matrices vitreuses bioprotectrices tréhalose-glycérol pour lesquelles les effets plastifiants/anti-plastifiants de l’eau résiduelle ont été étudiés.

The mechanisms of protein stabilization in solution and dry state have been investigated in this thesis. New therapeutic approaches are developing from many therapeutic biomolecules related to advances in recombinant DNA technology. Although we are not able to use them because of their low stability. The latter is improved in the dry state albeit freeze-drying gets a source of stress for many proteins. This work has mainly focused on the stability of model proteins, by in-situ Raman micro-spectroscopy during freeze-drying. The analysis identified the origin and the process of denaturation and the structural transformations of the inherent protein freeze-drying. Raman mapping was implemented at different stages of drying cycle, leading to the description of the protein/solvent/co-solvent interactions and decrypting the protein stabilizing mechanisms during the whole freeze-drying process. The protein stability was also analyzed during accelerated aging, by using several biopreservers. It revealed that the bioprotective efficiency of trehalose is enhanced by adding a small amount of glycerol. Molecular dynamics simulations were also carried out on trehalose-glycerol glassy matrices and the plasticizing / anti- plasticizing effects of the residual water were studied.

Advisors/Committee Members: Hedoux, Alain (thesis director), Affouard, Frédéric (thesis director).

Subjects/Keywords: Agents bioprotecteurs; 547.7

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APA (6^th Edition):

Achir, S. (2014). Etude des mécanismes de stabilisation des protéines par spectroscopie Raman et dynamique moléculaire : The protein stabilizing mechanisms investigated by Raman scattering and molecular dynamics simulations. (Doctoral Dissertation). Université Lille I – Sciences et Technologies. Retrieved from http://www.theses.fr/2014LIL10022

Chicago Manual of Style (16^th Edition):

Achir, Samira. “Etude des mécanismes de stabilisation des protéines par spectroscopie Raman et dynamique moléculaire : The protein stabilizing mechanisms investigated by Raman scattering and molecular dynamics simulations.” 2014. Doctoral Dissertation, Université Lille I – Sciences et Technologies. Accessed January 19, 2021. http://www.theses.fr/2014LIL10022.

MLA Handbook (7^th Edition):

Achir, Samira. “Etude des mécanismes de stabilisation des protéines par spectroscopie Raman et dynamique moléculaire : The protein stabilizing mechanisms investigated by Raman scattering and molecular dynamics simulations.” 2014. Web. 19 Jan 2021.

Vancouver:

Achir S. Etude des mécanismes de stabilisation des protéines par spectroscopie Raman et dynamique moléculaire : The protein stabilizing mechanisms investigated by Raman scattering and molecular dynamics simulations. [Internet] [Doctoral dissertation]. Université Lille I – Sciences et Technologies; 2014. [cited 2021 Jan 19]. Available from: http://www.theses.fr/2014LIL10022.

Council of Science Editors:

Achir S. Etude des mécanismes de stabilisation des protéines par spectroscopie Raman et dynamique moléculaire : The protein stabilizing mechanisms investigated by Raman scattering and molecular dynamics simulations. [Doctoral Dissertation]. Université Lille I – Sciences et Technologies; 2014. Available from: http://www.theses.fr/2014LIL10022

Punjabi University

10. Vijay Kumar. Heterocyclyl linked a- alkoxy carboxylic acids as novel antidiabetic agents: design synthesis and computational validation studies; -.

Degree: Chemistry, 2012, Punjabi University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/10230

►

The discovery of the crucial role of Peroxisome Proliferator Activated Receptors (PPARs) as regulators of lipid and glucose metabolism has raised interest in the development… (more)

▼

The discovery of the crucial role of Peroxisome Proliferator Activated Receptors (PPARs) as regulators of lipid and glucose metabolism has raised interest in the development of synthetic ligands as potential tool for therapeutic intervention in type 2 diabetes mellitus (T2DM) and metabolic syndrome. newlineAn important class of compounds currently under focus in the same category is dual activators of Peroxisome Proliferator Activated Receptors (,). Each of these subtypes appears to be differentiated in a tissue-specific manner and to play a pivotal role in glucose and lipid homeostasis. Special efforts to design multiple activating molecules can be successfully made using computational methods. Knowledge of the 3D structure of all the targeted receptors is of an advantage. PPAR agonists enhance insulin action and promote glucose utilization in peripheral tissues. PPAR agonists improve insulin sensitivity associated with obesity and mediate their effects on lipid metabolism. Therefore PPAR/ dual activators provide superior profile toward the control of hyperglycemia and hypertriglyceridemia. So, we first aimed to work on the hypothesis that PPAR/ dual agonism must provide additive and positive synergistic pharmacology, and laid down certain objectives to meet and fulfill the issues facing the development of dual activating agonists: a balance between and activity. newlineThe fact that dual PPARand#945;/and#947; activators though highly potent agonists of PPARand#945; and and#947;; they lead to various undesirable adverse effects (cardiovascular, hepatic, carcinogenic etc.) came into picture in the due course of time during the research work. Partial agonism simultaneously to both the Receptors may provide solution to the problem of toxic adverse effects of dual activators. newlineWe accordingly planned to synthesize and validate computationally heterocyclyl linked acyclic analogs of oxazolidinediones i.e. and#945;-alkoxy propanoic acids, as was designed on the basis of 3D-QSAR studies, having almost all the structural features to act

References p.591-635

Advisors/Committee Members: Verma, Raman K.

Subjects/Keywords: Chemistry; antidiabetic agents

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APA (6^th Edition):

Kumar, V. (2012). Heterocyclyl linked a- alkoxy carboxylic acids as novel antidiabetic agents: design synthesis and computational validation studies; -. (Thesis). Punjabi University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/10230

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kumar, Vijay. “Heterocyclyl linked a- alkoxy carboxylic acids as novel antidiabetic agents: design synthesis and computational validation studies; -.” 2012. Thesis, Punjabi University. Accessed January 19, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/10230.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kumar, Vijay. “Heterocyclyl linked a- alkoxy carboxylic acids as novel antidiabetic agents: design synthesis and computational validation studies; -.” 2012. Web. 19 Jan 2021.

Vancouver:

Kumar V. Heterocyclyl linked a- alkoxy carboxylic acids as novel antidiabetic agents: design synthesis and computational validation studies; -. [Internet] [Thesis]. Punjabi University; 2012. [cited 2021 Jan 19]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/10230.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kumar V. Heterocyclyl linked a- alkoxy carboxylic acids as novel antidiabetic agents: design synthesis and computational validation studies; -. [Thesis]. Punjabi University; 2012. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/10230

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Nelson Mandela Metropolitan University

11. [No author]. The metabolism and environmental fate of the cyanobacterial neurotoxin Beta-N-methylamino-L-alanine.

Degree: Faculty of Science, 2015, Nelson Mandela Metropolitan University

URL: http://hdl.handle.net/10948/4225

► The neurotoxic amino acid β-‐N-‐methylamino-Lalanine (BMAA)is present in environmentally ubiquitous cyanobacteria and bioaccumulates and biomagnifies within the environment. The implication of BMAA in the development… (more)

Subjects/Keywords: Cyanobacteria; Neurotoxic agents

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APA (6^th Edition):

author], [. (2015). The metabolism and environmental fate of the cyanobacterial neurotoxin Beta-N-methylamino-L-alanine. (Thesis). Nelson Mandela Metropolitan University. Retrieved from http://hdl.handle.net/10948/4225

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

author], [No. “The metabolism and environmental fate of the cyanobacterial neurotoxin Beta-N-methylamino-L-alanine.” 2015. Thesis, Nelson Mandela Metropolitan University. Accessed January 19, 2021. http://hdl.handle.net/10948/4225.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

author], [No. “The metabolism and environmental fate of the cyanobacterial neurotoxin Beta-N-methylamino-L-alanine.” 2015. Web. 19 Jan 2021.

Vancouver:

author] [. The metabolism and environmental fate of the cyanobacterial neurotoxin Beta-N-methylamino-L-alanine. [Internet] [Thesis]. Nelson Mandela Metropolitan University; 2015. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/10948/4225.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

author] [. The metabolism and environmental fate of the cyanobacterial neurotoxin Beta-N-methylamino-L-alanine. [Thesis]. Nelson Mandela Metropolitan University; 2015. Available from: http://hdl.handle.net/10948/4225

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Oregon State University

12. Almabruk, Khaled Husain G. Development and testing of novel anti-tubercular drugs.

Degree: MS, Pharmacy, 2010, Oregon State University

URL: http://hdl.handle.net/1957/18616

► Tuberculoѕiѕ (TB) iѕ a number one killer among treatable infectious diseases. It is caused by the pathogenic bacterium Mycobacterium tuberculoѕiѕ that primarily affects the lungѕ.… (more)

▼ Tuberculoѕiѕ (TB) iѕ a number one killer among treatable infectious diseases. It is caused by the pathogenic bacterium Mycobacterium tuberculoѕiѕ that primarily affects the lungѕ. It infects one third of the world population and kills approximately 2 million people each year (based on WHO report). Drug-reѕiѕtant TB haѕ become a very ѕeriouѕ problem in recent yearѕ in certain populationѕ. Therefore, the discovery and development of novel anti-tubercular drugs is a matter of emergency. Our research goal focused on the discovery of new drug candidates that can be developed as new anti-tubercular drugs. We employed semi-synthetic approaches using naturally derived compounds, 27-O-demethylrifamycin SV (DMRSV), 27-O-demethyl-25-O-deacetylrifamycin SV (DMDARSV), and validoxylamine A, as scaffolds. DMRSV and DMDARSV were obtained from a mutant strain of the rifamycin producing bacterium Amycolatopsis mediterranei S699, in which the methyltransferase gene within the rifamycin biosynthetic gene cluster has been inactivated. The compounds were modified by attaching a side chain diethylaminomethyl to the C-3 position. The products were tested for their activity against Mycobacterium smegmatis, B. subtilis, P. aeruginosa and S. aureus. However, the activity of DMRSV and DMDARSV derivatives were almost the same or less than that of 3-[(N,N-diethyl)-aminomethyl]-rifamycin SV. Validoxylamine A is a degradation product of the antifungal agent validamycin A. Structurally, it mimics trehalose, which is found in many bacteria and fungi, but not in the vertebrates. In M. tuberculosis, trehalose-6,6'-dimycolate (TDM) and trehalose-6-monomycolate (TMM) as well as other trehalose esters are important components of the cell wall and play a role in pathogenicity. Due to its similarity to trehalose, it is postulated that the ether derivatives of validoxylamine A could interfere with TMM and TDM synthesis and/or transport, as well as M. tuberculosis cell wall biosynthesis. To this end, we modified validoxylamine A by attaching various alkyl groups to the C-7 and C-7' positions of the compound, followed by reducing the C5-C6 double bond. The products were tested against M. smegmatis using agar diffusion and microdilution assays. The results showed that a number of validoxylamine A derivatives have significant antibacterial activity and an appropriate length of the side chain is critical for their activity. Compounds with alkyl chain range between C6 – C10 showed significant activity against M. smegmatis, whereas compounds with alkyl chains shorter than C6 or higher than C10 showed little or no activity. To confirm that this activity was not due to a detergent effect, we tested one of the active compounds against different strains of Gram (+) and Gram (-) bacteria, such as S. aureus, B. subtilis, and E. coli. The result showed that the active compound killed S. aureus and E. coli but not B. subtilis. Further testing against human cells (SF-295 glioma) revealed that the active compounds have no significant cytotoxicity. The results suggested… Advisors/Committee Members: Mahmud, Taifo (advisor), Zabriskie, Mark (committee member).

Subjects/Keywords: Antitubercular agents – Testing

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APA (6^th Edition):

Almabruk, K. H. G. (2010). Development and testing of novel anti-tubercular drugs. (Masters Thesis). Oregon State University. Retrieved from http://hdl.handle.net/1957/18616

Chicago Manual of Style (16^th Edition):

Almabruk, Khaled Husain G. “Development and testing of novel anti-tubercular drugs.” 2010. Masters Thesis, Oregon State University. Accessed January 19, 2021. http://hdl.handle.net/1957/18616.

MLA Handbook (7^th Edition):

Almabruk, Khaled Husain G. “Development and testing of novel anti-tubercular drugs.” 2010. Web. 19 Jan 2021.

Vancouver:

Almabruk KHG. Development and testing of novel anti-tubercular drugs. [Internet] [Masters thesis]. Oregon State University; 2010. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/1957/18616.

Council of Science Editors:

Almabruk KHG. Development and testing of novel anti-tubercular drugs. [Masters Thesis]. Oregon State University; 2010. Available from: http://hdl.handle.net/1957/18616

13. Truong, Minh Thai. To Develop a Database Management Tool for Multi-Agent Simulation Platform : Développement d'un outil de gestion de bases de données par une plateforme de simulation multi-agent.

Degree: Docteur es, Informatique, 2015, Université Toulouse I – Capitole

URL: http://www.theses.fr/2015TOU10003

► Depuis peu, la Modélisation et Simulation par Agents (ABMs) est passée d'une approche dirigée par les modèles à une approche dirigée par les données (Data… (more)

▼ Depuis peu, la Modélisation et Simulation par Agents (ABMs) est passée d'une approche dirigée par les modèles à une approche dirigée par les données (Data Driven Approach, DDA). Cette tendance vers l’utilisation des données dans la simulation vise à appliquer les données collectées par les systèmes d’observation à la simulation (Edmonds and Moss, 2005; Hassan, 2009). Dans la DDA, les données empiriques collectées sur les systèmes cibles sont utilisées non seulement pour la simulation des modèles mais aussi pour l’initialisation, la calibration et l’évaluation des résultats issus des modèles de simulation, par exemple, le système d’estimation et de gestion des ressources hydrauliques du bassin Adour-Garonne Français (Gaudou et al., 2013) et l’invasion des rizières du delta du Mékong au Vietnam par les cicadelles brunes (Nguyen et al., 2012d). Cette évolution pose la question du « comment gérer les données empiriques et celles simulées dans de tels systèmes ». Le constat que l’on peut faire est que, si la conception et la simulation actuelles des modèles ont bénéficié des avancées informatiques à travers l’utilisation des plateformes populaires telles que Netlogo (Wilensky, 1999) ou GAMA (Taillandier et al., 2012), ce n'est pas encore le cas de la gestion des données, qui sont encore très souvent gérées de manière ad-hoc. Cette gestion des données dans des Modèles Basés Agents (ABM) est une des limitations actuelles des plateformes de simulation multiagents (SMA). Autrement dit, un tel outil de gestion des données est actuellement requis dans la construction des systèmes de simulation par agents et la gestion des bases de données correspondantes est aussi un problème important de ces systèmes. Dans cette thèse, je propose tout d’abord une structure logique pour la gestion des données dans des plateformes de SMA. La structure proposée qui intègre des solutions de l’Informatique Décisionnelle et des plateformes multi-agents s’appelle CFBM (Combination Framework of Business intelligence and Multi-agent based platform), elle a plusieurs objectifs : (1) modéliser et exécuter des SMAs, (2) gérer les données en entrée et en sortie des simulations, (3) intégrer les données de différentes sources, et (4) analyser les données à grande échelle. Ensuite, le besoin de la gestion des données dans les simulations agents est satisfait par une implémentation de CFBM dans la plateforme GAMA. Cette implémentation présente aussi une architecture logicielle pour combiner entrepôts deIv données et technologies du traitement analytique en ligne (OLAP) dans les systèmes SMAs. Enfin, CFBM est évaluée pour la gestion de données dans la plateforme GAMA à travers le développement de modèles de surveillance des cicadelles brunes (BSMs), où CFBM est utilisé non seulement pour gérer et intégrer les données empiriques collectées depuis le système cible et les résultats de simulation du modèle simulé, mais aussi calibrer et valider ce modèle. L'intérêt de CFBM réside non seulement dans l'amélioration des faiblesses des plateformes de simulation et de… Advisors/Committee Members: Sibertin-Blanc, Christophe (thesis director), Amblard, Frédéric (thesis director), Gaudou, Benoît (thesis director).

Subjects/Keywords: Modèle par agents

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APA (6^th Edition):

Truong, M. T. (2015). To Develop a Database Management Tool for Multi-Agent Simulation Platform : Développement d'un outil de gestion de bases de données par une plateforme de simulation multi-agent. (Doctoral Dissertation). Université Toulouse I – Capitole. Retrieved from http://www.theses.fr/2015TOU10003

Chicago Manual of Style (16^th Edition):

Truong, Minh Thai. “To Develop a Database Management Tool for Multi-Agent Simulation Platform : Développement d'un outil de gestion de bases de données par une plateforme de simulation multi-agent.” 2015. Doctoral Dissertation, Université Toulouse I – Capitole. Accessed January 19, 2021. http://www.theses.fr/2015TOU10003.

MLA Handbook (7^th Edition):

Truong, Minh Thai. “To Develop a Database Management Tool for Multi-Agent Simulation Platform : Développement d'un outil de gestion de bases de données par une plateforme de simulation multi-agent.” 2015. Web. 19 Jan 2021.

Vancouver:

Truong MT. To Develop a Database Management Tool for Multi-Agent Simulation Platform : Développement d'un outil de gestion de bases de données par une plateforme de simulation multi-agent. [Internet] [Doctoral dissertation]. Université Toulouse I – Capitole; 2015. [cited 2021 Jan 19]. Available from: http://www.theses.fr/2015TOU10003.

Council of Science Editors:

Truong MT. To Develop a Database Management Tool for Multi-Agent Simulation Platform : Développement d'un outil de gestion de bases de données par une plateforme de simulation multi-agent. [Doctoral Dissertation]. Université Toulouse I – Capitole; 2015. Available from: http://www.theses.fr/2015TOU10003

Université Laval

14. Roy, Marie-Claude. Implication de la protéine découplante 2 (UCP2) dans la réponse au stress.

Degree: 2014, Université Laval

URL: http://hdl.handle.net/20.500.11794/25145

►

Les protéines découplantes (UCPs) sont situées dans la membrane interne des mitochondries. La première découverte, UCP1, est connue pour son potentiel à découpler la synthèse… (more)

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Les protéines découplantes (UCPs) sont situées dans la membrane interne des mitochondries. La première découverte, UCP1, est connue pour son potentiel à découpler la synthèse de l’adénosine 5’ triphosphate (ATP) de l’oxydation des substrats énergétiques, ce qui entraîne une accélération du métabolisme et une production de chaleur. La protéine découplante 2 (UCP2), est distribuée de façon ubiquitaire et semble plutôt réguler la production des espèces réactives de l’oxygène (ROS) et l’utilisation des substrats énergétiques. À notre connaissance, le rôle d’UCP2 dans les différents segments de l’axe hypothalamo-hypophyso-surrénalien (hypothalamic-pituitary-adrenal — HPA) est encore peu connu, tout comme l’implication potentielle de cette protéine dans la réponse au stress. Lors de cette étude, nous avons (i) regardé la distribution de l’ARN messager d’Ucp2 dans l’axe HPA, (ii) évalué les effets du stress sur l’expression d’Ucp2 et (iii) utilisé un modèle de souris déficiente en Ucp2 (Ucp2 KO) afin d’évaluer la réponse au stress en l’absence d’Ucp2. Sans avoir détecté de différence majeure dans la réponse au stress entre les souris de type sauvage (Wild-type — WT) et Ucp2 KO, il est sans équivoque qu’Ucp2 est exprimée en abondance dans l’axe HPA et que plusieurs régions du cerveau exprimant Ucp2 présentent une activation suite au stress.

Uncoupling proteins (UCPs) are located in the inner membrane of mitochondria. The first discovered uncoupling protein 1 (UCP1) is well known for its potential to uncouple adenosine 5’ triphosphate (ATP) synthesis from energetic substrate oxidation, resulting in heat production. Its partially homologue uncoupling protein 2 (UCP2) is found in several tissues and has been reported to reduce reactive oxygen species (ROS) production and seems implicated in the regulation of energetic substrates. According to our knowledge, the expression of Ucp2 in the hypothalamic-pituitary-adrenal (HPA) axis has not been described yet, neither its implication in stress response. Our study presents i) the distribution of Ucp2 mRNA in the HPA axis, ii) the effect of stress on Ucp2 expression in the brain and HPA axis and iii) the stress response of Ucp2 deficient mice (Ucp2 KO) to evaluate whether or not the absence of Ucp2 affects the stress response in mice. Although we do not detect any difference between Ucp2 KO mice and wild type (WT) mice following a stress, we have shown that Ucp2 is expressed in abundance in the HPA axis. Many brain regions also present an increase in Ucp2 expression after a stress.

Advisors/Committee Members: Richard, Denis.

Subjects/Keywords: Agents découplants; Stress

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APA (6^th Edition):

Roy, M. (2014). Implication de la protéine découplante 2 (UCP2) dans la réponse au stress. (Thesis). Université Laval. Retrieved from http://hdl.handle.net/20.500.11794/25145

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Roy, Marie-Claude. “Implication de la protéine découplante 2 (UCP2) dans la réponse au stress.” 2014. Thesis, Université Laval. Accessed January 19, 2021. http://hdl.handle.net/20.500.11794/25145.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Roy, Marie-Claude. “Implication de la protéine découplante 2 (UCP2) dans la réponse au stress.” 2014. Web. 19 Jan 2021.

Vancouver:

Roy M. Implication de la protéine découplante 2 (UCP2) dans la réponse au stress. [Internet] [Thesis]. Université Laval; 2014. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/20.500.11794/25145.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Roy M. Implication de la protéine découplante 2 (UCP2) dans la réponse au stress. [Thesis]. Université Laval; 2014. Available from: http://hdl.handle.net/20.500.11794/25145

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Baylor University

15. Jones, Lindsay M. Design and synthesis of functionalized small-molecule inhibitors of cathepsins L and K.

Degree: PhD, Chemistry and Biochemistry., 2012, Baylor University

URL: http://hdl.handle.net/2104/8438

► Inhibition of a class of cysteine proteases known as the cathepsins has received increasing attention in recent years, since these enzymes play key roles in… (more)

Subjects/Keywords: Anti-cancer agents.

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APA (6^th Edition):

Jones, L. M. (2012). Design and synthesis of functionalized small-molecule inhibitors of cathepsins L and K. (Doctoral Dissertation). Baylor University. Retrieved from http://hdl.handle.net/2104/8438

Chicago Manual of Style (16^th Edition):

Jones, Lindsay M. “Design and synthesis of functionalized small-molecule inhibitors of cathepsins L and K.” 2012. Doctoral Dissertation, Baylor University. Accessed January 19, 2021. http://hdl.handle.net/2104/8438.

MLA Handbook (7^th Edition):

Jones, Lindsay M. “Design and synthesis of functionalized small-molecule inhibitors of cathepsins L and K.” 2012. Web. 19 Jan 2021.

Vancouver:

Jones LM. Design and synthesis of functionalized small-molecule inhibitors of cathepsins L and K. [Internet] [Doctoral dissertation]. Baylor University; 2012. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2104/8438.

Council of Science Editors:

Jones LM. Design and synthesis of functionalized small-molecule inhibitors of cathepsins L and K. [Doctoral Dissertation]. Baylor University; 2012. Available from: http://hdl.handle.net/2104/8438

16. Sobieraj, Jérémy. Méthodes et outils pour la conception de systèmes de transport intelligents coopératifs : Methods and tools for the design of cooperative intelligent transportation systems.

Degree: Docteur es, Informatique, 2018, Université Paris-Saclay (ComUE)

URL: http://www.theses.fr/2018SACLE038

►

La voiture est le mode de transport le plus utilisé en Europe et en Amérique du Nord. Aujourd’hui, il est de plus en plus sécurisé… (more)

▼

La voiture est le mode de transport le plus utilisé en Europe et en Amérique du Nord. Aujourd’hui, il est de plus en plus sécurisé notamment grâce à des systèmes d’assistance à la conduite. Toutefois, il représente encore la plus grande part d’accidents sur la route en France dont 90 % seraient de cause humaine. A partir de 2020, de nouveaux types de véhicules vont apparaître sur la route : ce sont des véhicules dont la décision ne dépendra plus uniquement du conducteur humain, appelés couramment véhicules autonomes.Pour concevoir de tels systèmes, trois grandes exigences doivent être respectées à la fois : la sécurité (respect du code de la route), l’efficacité (aller le plus vite possible) et le confort (ne pas se sentir en danger dans le véhicule). En plus d’imaginer un véhicule où seuls les capteurs embarqués fournissent les informations nécessaires pour conduire, on peut ajouter la possibilité de communiquer avec d’autres véhicules ou l’infrastructure de la route. Ce dernier point doit prendre en compte une quatrième exigence, la courtoisie (ne pas avoir un impact négatif sur les véhicules environnants). Il peut permettre également de gérer une situation proche où les véhicules conduits par des êtres humains et les véhicules autonomes vont se trouver dans un même environnement.Pour étudier ces comportements, la simulation informatique peut être une bonne solution pour mettre en place un éventail de scénarios possibles dans différents environnements. Toutefois, cela impose un niveau d’abstraction pouvant affecter le niveau de réalisme du modèle.Dans ce manuscrit, nous avons défini des méthodes et outils afin de définir une méthodologie permettant de concevoir des Systèmes de Transport Intelligents Coopératifs. A partir d'un modèle de véhicule, nous allons le simuler, puis le vérifier formellement. A partir du modèle obtenu, on assure une compatibilité avec un simulateur plus réaliste. De plus, à partir d'un outil de simulation, nous avons mis en place un protocole de coopération permettant aux véhicules de s’adapter plus facilement à des environnements routiers actuels.

The car is the most used mode of transport in Europe and North America. Today, it is increasingly secure thanks to driver assistance systems. However, it is still the largest share of road accidents in France, 90 % of which are caused by humans. From 2020, new types of vehicles will appear on the road: they are vehicles whose decision will no longer depend only on the human driver, commonly called autonomous vehicles.To design such systems, three main requirements must be respected at the same time: the safety (respect of traffic laws), the efficiency (go as fast as possible) and the comfort (not to feel in danger in the vehicle). In addition to imagine a vehicle where only on-board sensors provide the necessary information to drive, one can add the ability to communicate with other vehicles or the road infrastructure. This last point have to take into account a fourth requirement, courtesy (does not have a negative impact on surrounding…

Advisors/Committee Members: Hutzler, Guillaume (thesis director).

Subjects/Keywords: Systèmes Multi-Agents

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sobieraj, J. (2018). Méthodes et outils pour la conception de systèmes de transport intelligents coopératifs : Methods and tools for the design of cooperative intelligent transportation systems. (Doctoral Dissertation). Université Paris-Saclay (ComUE). Retrieved from http://www.theses.fr/2018SACLE038

Chicago Manual of Style (16^th Edition):

Sobieraj, Jérémy. “Méthodes et outils pour la conception de systèmes de transport intelligents coopératifs : Methods and tools for the design of cooperative intelligent transportation systems.” 2018. Doctoral Dissertation, Université Paris-Saclay (ComUE). Accessed January 19, 2021. http://www.theses.fr/2018SACLE038.

MLA Handbook (7^th Edition):

Sobieraj, Jérémy. “Méthodes et outils pour la conception de systèmes de transport intelligents coopératifs : Methods and tools for the design of cooperative intelligent transportation systems.” 2018. Web. 19 Jan 2021.

Vancouver:

Sobieraj J. Méthodes et outils pour la conception de systèmes de transport intelligents coopératifs : Methods and tools for the design of cooperative intelligent transportation systems. [Internet] [Doctoral dissertation]. Université Paris-Saclay (ComUE); 2018. [cited 2021 Jan 19]. Available from: http://www.theses.fr/2018SACLE038.

Council of Science Editors:

Sobieraj J. Méthodes et outils pour la conception de systèmes de transport intelligents coopératifs : Methods and tools for the design of cooperative intelligent transportation systems. [Doctoral Dissertation]. Université Paris-Saclay (ComUE); 2018. Available from: http://www.theses.fr/2018SACLE038

Nelson Mandela Metropolitan University

17. Ramjan, Yumna. Development of a framework for a proposed antimicrobial usage reporting tool for public sector hospitals.

Degree: 2019, Nelson Mandela Metropolitan University

URL: http://hdl.handle.net/10948/43030

► Background: The inappropriate and unnecessary use of antimicrobials has increased the need to monitor antimicrobial usage so as to identify inappropriate use. In order to… (more)

▼ Background: The inappropriate and unnecessary use of antimicrobials has increased the need to monitor antimicrobial usage so as to identify inappropriate use. In order to support the antimicrobial stewardship (AMS) programme, it is important to quantify the usage of antimicrobials and this can be achieved by promoting the use of AMS utilisation metrics. They are used to measure the progress and efficacy of an AMS programme (Brotherton, 2018).Primary Aim of Research: The primary aim of the research was to develop a framework for a proposed antimicrobial usage reporting tool, which would integrate with various data sources in order to be used by AMS practitioners to optimise antimicrobial usage in the South African public sector hospital setting.Methodology: The study was divided into three phases: a preliminary phase, a developmental phase and a post-developmental phase. The preliminary phase focused on obtaining a comprehensive understanding of the type and nature of the AMS utilisation metrics and subsequently identifying the views on the usage, usefulness and clinical relevance of those AMS utilisation metrics using a quantitative questionnaire, which was conducted among infectious disease specialists, pharmacists, medical prescribers, i.e. prescribers who were not specialists and clinical pathologists employed at tertiary level, public sector hospitals in the Eastern Cape province of South Africa. Consequently, a qualitative semi-structured interview was conducted among healthcare professionals who were involved in the daily implementation of AMS in the workplace. Results obtained from the quantitative component and qualitative component were integrated in order to develop a framework for a proposed antimicrobial usage reporting tool. Results: The Defined Daily Dose (DDD), Prescribed Daily Dose (PDD) and Days of Therapy (DOT) were identified as the most common AMS metrics (Grau et al., 2013). However, the DDD was the only AMS metric currently recommended by the South African National Department of Health (South African National Department of Health, 2017a)and it was the only AMS metric currently being utilised at two of the five research sites in the Eastern Cape province of South Africa. It was identified that data pertaining to antimicrobial usage was available and was being extracted from Rx Solution®. However, the programme did not have the ability of automatically producing the reports, hence, emphasising on the need for an antimicrobial usage reporting tool for South African public sector hospitals. Therefore, the framework for the proposed antimicrobial usage reporting tool would integrate antimicrobial stock management data with the following AMS utilisation metrics: DDD, DOT and PDD, were considered for inclusion in the proposed antimicrobial usage reporting tool. Conclusion: The qualitative findings obtained during the post-developmental phase, therefore, established that although an electronic platform for the purpose of monitoring antimicrobial usage for the South African public sector hospitals was…

Subjects/Keywords: Anti-infective agents

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ramjan, Y. (2019). Development of a framework for a proposed antimicrobial usage reporting tool for public sector hospitals. (Thesis). Nelson Mandela Metropolitan University. Retrieved from http://hdl.handle.net/10948/43030

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ramjan, Yumna. “Development of a framework for a proposed antimicrobial usage reporting tool for public sector hospitals.” 2019. Thesis, Nelson Mandela Metropolitan University. Accessed January 19, 2021. http://hdl.handle.net/10948/43030.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ramjan, Yumna. “Development of a framework for a proposed antimicrobial usage reporting tool for public sector hospitals.” 2019. Web. 19 Jan 2021.

Vancouver:

Ramjan Y. Development of a framework for a proposed antimicrobial usage reporting tool for public sector hospitals. [Internet] [Thesis]. Nelson Mandela Metropolitan University; 2019. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/10948/43030.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ramjan Y. Development of a framework for a proposed antimicrobial usage reporting tool for public sector hospitals. [Thesis]. Nelson Mandela Metropolitan University; 2019. Available from: http://hdl.handle.net/10948/43030

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Rutgers University

18. Yin, Ruiheng. Structural basis of transcription inhibition by the nucleoside-analog inhibitor thuringiensin.

Degree: MS, Biochemistry, 2016, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/50492/

► Thuringiensin (Thg), also known as β-exotoxin, is an adenosine-containing secondary metabolite produced by the soil bacterium Bacillus thuringiensis. Thg exerts broad spectrum bactericidal activity, insecticidal… (more)

▼ Thuringiensin (Thg), also known as β-exotoxin, is an adenosine-containing secondary metabolite produced by the soil bacterium Bacillus thuringiensis. Thg exerts broad spectrum bactericidal activity, insecticidal activity, and mammalian toxicity by inhibiting bacterial RNA polymerase (RNAP) and eukaryotic RNAP I, II, and III. Biochemical evidence indicates that Thg inhibits RNAP by functioning as a nucleoside-analog inhibitor (NAI) that competes with ATP for occupancy of the RNAP active center "i+1" nucleotide binding site. We have determined a crystal structure of a Thermus thermophilus initial transcribing complex in complex with Thg (RPo-GpA-Thg; resolution = 3.2 Å; Rfree = 25.4%). The structure shows that Thg occupies the RNAP active-center "i+1" nucleotide-binding site. The adenine and ribose moieties of Thg make the same interactions with a DNA template-strand thymine, the RNA 3' nucleotide base, and the RNAP "i+1" NTP binding site as are made by the adenine and ribose moieties of ATP. The phosphate, allaric acid, and glucose moieties of Thg make interactions that mimic interactions made by the triphosphate moiety of ATP. In particular, the phosphate moiety of Thg occupies essentially the same position as is occupied by the  phosphate of ATP, and the phosphate moiety and one carboxy group of the allaric acid moiety of Thg coordinate a Mg2+ ion (Mg2+ II) in essentially the same manner and same position as the -phosphate and -phosphate of ATP coordinate Mg2+ II. The structure shows conclusively that Thg inhibits RNAP by functioning as an NAI that competes with ATP for binding to the RNAP active center "i+1" nucleotide binding site. This structure of RNAP in complex with the non-selective NAI Thg is one of the first two structures of a bacterial RNAP in complex with an NAI. NAIs of viral nucleotide polymerases have been the subject of intense interest, and immense importance, for the development of anti-HIV and anti-HCV drugs. NAIs of bacterial RNAP only now are beginning to be explored, but show high promise for the development of antibacterial drugs. The structures of the RNAP-Thg complexes provide a starting point for structure-based understanding of bacterial-RNAP-selectivity of NAIs and for structure-based design of more potent bacterial-RNAP-selective NAIs. Advisors/Committee Members: Ebright, Richard (chair), Arnold, Eddy (internal member), Olson, Wilma (internal member).

Subjects/Keywords: Antibacterial agents; Nucleosides

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Yin, R. (2016). Structural basis of transcription inhibition by the nucleoside-analog inhibitor thuringiensin. (Masters Thesis). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/50492/

Chicago Manual of Style (16^th Edition):

Yin, Ruiheng. “Structural basis of transcription inhibition by the nucleoside-analog inhibitor thuringiensin.” 2016. Masters Thesis, Rutgers University. Accessed January 19, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/50492/.

MLA Handbook (7^th Edition):

Yin, Ruiheng. “Structural basis of transcription inhibition by the nucleoside-analog inhibitor thuringiensin.” 2016. Web. 19 Jan 2021.

Vancouver:

Yin R. Structural basis of transcription inhibition by the nucleoside-analog inhibitor thuringiensin. [Internet] [Masters thesis]. Rutgers University; 2016. [cited 2021 Jan 19]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/50492/.

Council of Science Editors:

Yin R. Structural basis of transcription inhibition by the nucleoside-analog inhibitor thuringiensin. [Masters Thesis]. Rutgers University; 2016. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/50492/

University of New South Wales

19. Gorle, Anil Kumar. Polypyridylruthenium(II) complexes as therapeutic agents.

Degree: Physical, Environmental & Mathematical Sciences, 2015, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/55233 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:36838/SOURCE02?view=true

► A series of dinuclear ruthenium(II) complexes containing labile chlorido ligands (Cl-Rubbn) have been synthesised and their potential as anticancer agents examined. Some of the Cl-Rubbn… (more)

▼ A series of dinuclear ruthenium(II) complexes containing labile chlorido ligands (Cl-Rubbn) have been synthesised and their potential as anticancer agents examined. Some of the Cl-Rubbn species showed good anticancer activity against breast cancer cell lines, with the Cl-Rubb₁₂ complex being four-times more active than cisplatin. The results of this study suggest that the cytotoxicity of the dinuclear ruthenium complexes is a combination of covalent and reversible binding with DNA. A series of inert mono-, tri- and tetra-nuclear polypyridylruthenium(II) complexes have been synthesised and their potential as antimicrobial agents examined. Geometric isomers of the mononuclear complexes were separated. The minimum inhibitory concentrations (MIC) of the ruthenium(II) complexes were determined against a range of Gram positive and Gram negative bacteria. The linear tetranuclear complexes were generally more active, with MIC values < 1 μM against Gram positive bacteria. Of particular note, the cellular accumulation of the oligonuclear ruthenium complexes was greater in the Gram negative strains compared to that in the Gram positive strains. The mononuclear complexes [Ru(phen)(bbn)]²⁺ (phen=1,10-phenanthroline) exhibited excellent activity against Gram positive bacteria, but only the cis-α-[Ru(phen)(bb₁₂)]²⁺ species showed good activity against Gram negative species. In particular, the cis-α-[Ru(phen)(bb₁₂)]²⁺ complex was two to four times more active than the cis-β-[Ru(phen)(bb₁₂)]²⁺ complex against the Gram negative strains. The cis-α- and cis-β-[Ru(phen)(bb₁₂)]²⁺ complexes readily accumulated in the bacteria, but significantly, showed the highest level of uptake in P. aeruginosa. The antimicrobial activities of a series of di-, tri- and tetra-nuclear ruthenium complexes against a wider range of clinically relevant pathogenic bacteria were examined. The toxicity of some of these complexes against eukaryotic cells was also investigated. Results of this study indicate that these complexes are highly active against Gram positive bacteria but they were less active against Gram negative bacteria. The dinuclear Rubb₁₂complex exhibits less toxicity to liver and kidney cells when compared to the tri- and tetra-nuclear complexes. In addition, in vivo experiments demonstrate serum level concentrations for both Rubb₁₆ and Rubb₁₂-tetra were lower than the MIC values against Gram positive and Gram negative bacteria, with both complexes accumulating mainly in the liver and kidney after dosing. Advisors/Committee Members: Collins, Grant, Physical, Environmental & Mathematical Sciences, UNSW Canberra, UNSW.

Subjects/Keywords: antimicrobial agents; Polypyridylruthenium(II) complexes; Therapeutic agents; anticancer agents

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APA (6^th Edition):

Gorle, A. K. (2015). Polypyridylruthenium(II) complexes as therapeutic agents. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/55233 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:36838/SOURCE02?view=true

Chicago Manual of Style (16^th Edition):

Gorle, Anil Kumar. “Polypyridylruthenium(II) complexes as therapeutic agents.” 2015. Doctoral Dissertation, University of New South Wales. Accessed January 19, 2021. http://handle.unsw.edu.au/1959.4/55233 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:36838/SOURCE02?view=true.

MLA Handbook (7^th Edition):

Gorle, Anil Kumar. “Polypyridylruthenium(II) complexes as therapeutic agents.” 2015. Web. 19 Jan 2021.

Vancouver:

Gorle AK. Polypyridylruthenium(II) complexes as therapeutic agents. [Internet] [Doctoral dissertation]. University of New South Wales; 2015. [cited 2021 Jan 19]. Available from: http://handle.unsw.edu.au/1959.4/55233 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:36838/SOURCE02?view=true.

Council of Science Editors:

Gorle AK. Polypyridylruthenium(II) complexes as therapeutic agents. [Doctoral Dissertation]. University of New South Wales; 2015. Available from: http://handle.unsw.edu.au/1959.4/55233 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:36838/SOURCE02?view=true

Michigan State University

20. Grant, Calvin. Mechanistic investigation of (DHQD)₂PHAL catalysis in chlorination and dihydroxylation reactions using a naphthalene-based analogue.

Degree: 2018, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:19228

►

Thesis Ph. D. Michigan State University. Chemistry 2018

This dissertation is composed of three different projects, each discussed in a chapter. Following are short descriptions… (more)

▼

Thesis Ph. D. Michigan State University. Chemistry 2018

This dissertation is composed of three different projects, each discussed in a chapter. Following are short descriptions of the contained chapters.Because of the low financial potential gains in antimicrobial drug development, companies have not invested into the area, relying on naturally occurring compounds found within the last twenty to thirty years to keep the microbes at bay. In the mean time, microbes are developing resistance to the most consistently used antimicrobials. Strains such as pseudomonas aeruginosa and methicillin-resistant staphylococcus are becoming more prevalent with the ubiquitous use of antimicrobials in animal feeds, cosmetics, and even medications. In order to contribute to the search for new antibiotics, we searched for antimicrobial lead compounds tapping an easily accessible resource-repurposed laboratory compounds. The first chapter of this dissertation addresses the process of organizing, testing, and analysis of a library for antibacterial assays. A few of the positive antibacterial hits have been analyzed to investigate the mode-of-action of their class.In another study, discussed in chapter two, addresses a total synthesis of Alexine, a polyhydroxylated pyrrolizidine found to exhibit antiretroviral activity. While most syntheses of this family of pyrrolizidines utilized amino acids or sugars as templates, this synthesis relied on an aza-payne rearrangement and a one-carbon homologative relay ring expansion after incorporation of all necessary carbons required in the structure of alexine. This synthesis attempt ends with the formation of the initial pyrrolidine via our methodology and a proposal for the completion of the total synthesis.In the final chapter, for which the dissertation has been titled, new advancements in halofunctionalization that have been uncovered in the Borhan laboratory are further investigated. In particular, the hypothesis regarding the enantioselectivities seen when utilizing (DHQD)2PHAL under optimized conditions suggests that the high enantioselectivities seen in the halofunctionalization of unfunctionalized alkenes done by Borhan and coworkers are due to the rigidity of DHQD ligand-linker bonds C-O-C=N facilitated by the sp2 character of pendant oxygen as it donates into the electron deficient aromatic linker. In order to probe this, a naphthalene linker analogue (DHQD)2NAPH was synthesized and used as a catalyst in the optimized reactions. Computational studies were used to confirm the results and confirm the validity of the hypothesis.

Description based on online resource;

Advisors/Committee Members: Borhan, Babak, Wulff, William D, Geiger, James H, Huang, Xeufei.

Subjects/Keywords: Anti-infective agents; Antibacterial agents; Antiretroviral agents; Enantioselective catalysis; Chemistry

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APA (6^th Edition):

Grant, C. (2018). Mechanistic investigation of (DHQD)₂PHAL catalysis in chlorination and dihydroxylation reactions using a naphthalene-based analogue. (Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:19228

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Grant, Calvin. “Mechanistic investigation of (DHQD)₂PHAL catalysis in chlorination and dihydroxylation reactions using a naphthalene-based analogue.” 2018. Thesis, Michigan State University. Accessed January 19, 2021. http://etd.lib.msu.edu/islandora/object/etd:19228.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Grant, Calvin. “Mechanistic investigation of (DHQD)₂PHAL catalysis in chlorination and dihydroxylation reactions using a naphthalene-based analogue.” 2018. Web. 19 Jan 2021.

Vancouver:

Grant C. Mechanistic investigation of (DHQD)₂PHAL catalysis in chlorination and dihydroxylation reactions using a naphthalene-based analogue. [Internet] [Thesis]. Michigan State University; 2018. [cited 2021 Jan 19]. Available from: http://etd.lib.msu.edu/islandora/object/etd:19228.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Grant C. Mechanistic investigation of (DHQD)₂PHAL catalysis in chlorination and dihydroxylation reactions using a naphthalene-based analogue. [Thesis]. Michigan State University; 2018. Available from: http://etd.lib.msu.edu/islandora/object/etd:19228

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Duquesne University

21. Pavana, Roheeth. Design and Synthesis of Pyrimidine Fused Heterocycles as Single Agents with Combination Chemotherapy Potential.

Degree: PhD, Medicinal Chemistry, 2014, Duquesne University

URL: https://dsc.duq.edu/etd/67

► This dissertation describes the design, synthesis and biological evaluation of pyrimidine fused heterocycles as single agents with combination chemotherapy potential. Major limitations of cancer… (more)

▼ This dissertation describes the design, synthesis and biological evaluation of pyrimidine fused heterocycles as single agents with combination chemotherapy potential. Major limitations of cancer chemotherapy include dose limiting toxicities of clinically used agents and the development of multidrug resistance by the tumor. Agents that interfere with microtubules are important antitumor agents. Tumor angiogenic mechanisms that are vital for tumor growth and metastasis are targeted by antiangiogenic agents. Antiangiogenic agents are usually not tumoricidal but are mainly cytostatic. Combination chemotherapy with antiangiogenic and cytotoxic agents have shown significant promise and several studies with such combinations are in progress in the clinic. Single agents with both antiangiogenic activities as well as cytotoxicity would afford single agents that circumvent pharmacokinetic problems of multiple agents, avoid drug–drug interactions, could be used at lower doses to alleviate toxicity, be devoid of overlapping toxicities, and delay or prevent tumor cell resistance. The work in this dissertation is centered on the design and synthesis of single entities that have both antiangiogenic effects and cytotoxic effects. These efforts led to the identification of structural features that are necessary for inhibition of tubulin polymerization. Structural modifications also led to the identification of novel antiangiogenic agents which inhibit one or more of the receptor tyrosine kinases (RTKs)– vascular endothelial growth factor receptor–2 (VEGFR2), platelet derived growth factor receptor–β (PDGFRβ) and epidermal growth factor receptor (EGFR). The complexity of the angiogenic pathways in tumors implies that disrupting a single mechanism of angiogenesis may not result in significant clinical success. Multiple RTKs are co–activated in tumors and redundant inputs drive and maintain downstream signaling, thereby limiting the efficacy of therapies targeting single RTKs. This work reviews the role of RTKs in angiogenesis, microtubules as antitumor targets, the vascular normalization theory and multitargeted agents. This work also reviews the synthesis of substituted pyrrolo[3,2–d]pyrimidines, furo[3,2–d]pyrimidines, pyrimido[5,4–b]indoles and b]. A discussion of methods employed in the synthesis of pyrimidine fused heterocycles as single agents with combination chemotherapy potential is provided. Advisors/Committee Members: Aleem Gangjee, Marc Harrold, David Lapinsky, Patrick Flaherty.

Subjects/Keywords: Antiangiogenic agents; antimitotic agents; combination chemotherapy; endothelial growth factor receptor-2; single agents; tubulin

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pavana, R. (2014). Design and Synthesis of Pyrimidine Fused Heterocycles as Single Agents with Combination Chemotherapy Potential. (Doctoral Dissertation). Duquesne University. Retrieved from https://dsc.duq.edu/etd/67

Chicago Manual of Style (16^th Edition):

Pavana, Roheeth. “Design and Synthesis of Pyrimidine Fused Heterocycles as Single Agents with Combination Chemotherapy Potential.” 2014. Doctoral Dissertation, Duquesne University. Accessed January 19, 2021. https://dsc.duq.edu/etd/67.

MLA Handbook (7^th Edition):

Pavana, Roheeth. “Design and Synthesis of Pyrimidine Fused Heterocycles as Single Agents with Combination Chemotherapy Potential.” 2014. Web. 19 Jan 2021.

Vancouver:

Pavana R. Design and Synthesis of Pyrimidine Fused Heterocycles as Single Agents with Combination Chemotherapy Potential. [Internet] [Doctoral dissertation]. Duquesne University; 2014. [cited 2021 Jan 19]. Available from: https://dsc.duq.edu/etd/67.

Council of Science Editors:

Pavana R. Design and Synthesis of Pyrimidine Fused Heterocycles as Single Agents with Combination Chemotherapy Potential. [Doctoral Dissertation]. Duquesne University; 2014. Available from: https://dsc.duq.edu/etd/67

University of Zambia

22. Likando, Likando. A study to determine the quality of life of people living with HIV/AIDS before and during anti retroviral treatment .

Degree: 2013, University of Zambia

URL: http://hdl.handle.net/123456789/2047

► The quality of life in People Living with HIV/AIDS (PLWHA) prior to Highly Active Antiretroviral Therapy (HAART) is said to be poor. However, Anti-retroviral Therapy… (more)

▼ The quality of life in People Living with HIV/AIDS (PLWHA) prior to Highly Active Antiretroviral Therapy (HAART) is said to be poor. However, Anti-retroviral Therapy (ART) has changed the natural history of HIV/AIDS from a disease characterized by the rapid and torturous downhill progression to a chronic illness. HIV/AIDS has substantially increased the demand for health services and negatively affected the quality of life (Gill et al 2002). The aim of the study was to determine quality of life for PLWHA after commencement of ART. The Null hypothesis of the study was that the PLWHA would have a better quality of life after commencement of HAART. The study focused on people living with HIV/AIDS in Livingstone particularly those that were obtaining medical services from Livingstone General Hospital. The study assessed the quality of life of PLWHA before and during ART. It also established intentions on how to improve the quality of life of PLWHA before and during ART. The domains assessed included. Disease, Treatment, Pain, Energy, Physical, function, sleep and mental health domains. The study design used was retrospective. Total samples of 210 files for PLWHA were randomly selected from the registry at Livingstone General Hospital by systematic random sampling. Data were collected by using a Medical Outcome Scale Human Immunodeficiency Syndrome (MOS-HIV) questionnaire. The questionnaire was used as a checklist to extract data from the medical record files. The results of the study showed that the majority of PLWHA before ART experienced poor quality of life. In the disease domain, it was observed that disease domain had 176 (84%) PLWHA who were ill looking before ART, only 132 (63%) were still ill looking after 12 months of ART (P<0.001. The number of PLWHA with Cd4 cell count less than 200 cells/mm3 before ART was 161(77 %>) and at 12 months ART, the number reduced to 83 (40%)). The Haemoglobin level assessment also followed the same trend of improvement, as the number of PLWHA with low haemoglobin reduced from 181 (86.1%) to 125 (60%). Health status domain was described by the Physicians as poor or better. 46 (22%)) were described as poor health status before ART and the number reduced to 15 (7%) after 12 months of ART. (p < 001) The treatment domain looked at the side effects experienced by PLWHA during ART. The majority of the PLWHA, 128 (61%) experienced side effects. The most common side effect was neuropathy 54 (26%). Therefore, side effects can cause considerable discomfort and non adherence to ART hence negatively affecting the quality of life. Pain domain showed that 147 (70%) of PLWHA complained of pain before ART only 63 (30%o) did not complain. During 12 months of ART, 114 (54%) had no pain and only 96 (46%) had pain (p< 0.001). The study showed that 99 (47.1%)) had sleep disturbances before ART. During ART only 18 (7%) had sleep disturbances, (p < 0.001).Physical and role function domains assessed the ability of PLWHA to walk with ease or difficulty. Before ART, 126 (66.7%) of PLWHA had walking problems…

Subjects/Keywords: HIV/AIDS; Antiretroviral agents; Health

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Likando, L. (2013). A study to determine the quality of life of people living with HIV/AIDS before and during anti retroviral treatment . (Thesis). University of Zambia. Retrieved from http://hdl.handle.net/123456789/2047

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Likando, Likando. “A study to determine the quality of life of people living with HIV/AIDS before and during anti retroviral treatment .” 2013. Thesis, University of Zambia. Accessed January 19, 2021. http://hdl.handle.net/123456789/2047.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Likando, Likando. “A study to determine the quality of life of people living with HIV/AIDS before and during anti retroviral treatment .” 2013. Web. 19 Jan 2021.

Vancouver:

Likando L. A study to determine the quality of life of people living with HIV/AIDS before and during anti retroviral treatment . [Internet] [Thesis]. University of Zambia; 2013. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/123456789/2047.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Likando L. A study to determine the quality of life of people living with HIV/AIDS before and during anti retroviral treatment . [Thesis]. University of Zambia; 2013. Available from: http://hdl.handle.net/123456789/2047

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universiteit Utrecht

23. Vroman, H. Use of extracellular vesicles as biomarker for disease or as therapeutic target.

Degree: 2012, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/253294

► In recent years, novel ways of intercellular communication have been described involving extracellular vesicles. Cells from various origins actively release small vesicles into the extracellular… (more)

Subjects/Keywords: extracellular vesicles; biomarker; therapeutic agents

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APA (6^th Edition):

Vroman, H. (2012). Use of extracellular vesicles as biomarker for disease or as therapeutic target. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/253294

Chicago Manual of Style (16^th Edition):

Vroman, H. “Use of extracellular vesicles as biomarker for disease or as therapeutic target.” 2012. Masters Thesis, Universiteit Utrecht. Accessed January 19, 2021. http://dspace.library.uu.nl:8080/handle/1874/253294.

MLA Handbook (7^th Edition):

Vroman, H. “Use of extracellular vesicles as biomarker for disease or as therapeutic target.” 2012. Web. 19 Jan 2021.

Vancouver:

Vroman H. Use of extracellular vesicles as biomarker for disease or as therapeutic target. [Internet] [Masters thesis]. Universiteit Utrecht; 2012. [cited 2021 Jan 19]. Available from: http://dspace.library.uu.nl:8080/handle/1874/253294.

Council of Science Editors:

Vroman H. Use of extracellular vesicles as biomarker for disease or as therapeutic target. [Masters Thesis]. Universiteit Utrecht; 2012. Available from: http://dspace.library.uu.nl:8080/handle/1874/253294

Universiteit Utrecht

24. Dinther, R.J. van. Using Biosocial Theory as a Model for Agent Emotion.

Degree: 2016, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/338271

► With increased demand for agents that exhibit emotion-driven behaviour, models are required that facilitate implementation of those agents. A commonly used model for this purpose… (more)

Subjects/Keywords: agents; emotion; biosocial theory

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APA (6^th Edition):

Dinther, R. J. v. (2016). Using Biosocial Theory as a Model for Agent Emotion. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/338271

Chicago Manual of Style (16^th Edition):

Dinther, R J van. “Using Biosocial Theory as a Model for Agent Emotion.” 2016. Masters Thesis, Universiteit Utrecht. Accessed January 19, 2021. http://dspace.library.uu.nl:8080/handle/1874/338271.

MLA Handbook (7^th Edition):

Dinther, R J van. “Using Biosocial Theory as a Model for Agent Emotion.” 2016. Web. 19 Jan 2021.

Vancouver:

Dinther RJv. Using Biosocial Theory as a Model for Agent Emotion. [Internet] [Masters thesis]. Universiteit Utrecht; 2016. [cited 2021 Jan 19]. Available from: http://dspace.library.uu.nl:8080/handle/1874/338271.

Council of Science Editors:

Dinther RJv. Using Biosocial Theory as a Model for Agent Emotion. [Masters Thesis]. Universiteit Utrecht; 2016. Available from: http://dspace.library.uu.nl:8080/handle/1874/338271

25. Berrada El Azizi, Mohamed. Modélisation multi-agents de la coopération au sein des chaînes logistiques à deux échelons : application à la distribution de produits pharmaceutiques au Maroc : Modeling cooperation in tow level's supply chain : a multi-agents approach.

Degree: Docteur es, Sciences de gestion, 2014, Paris 13

URL: http://www.theses.fr/2014PA131020

►

Cette thèse sur travaux composée de quatre articles s’intéresse aux chaînes logistiques à deux échelons comportant un fournisseur en situation de monopole et de N… (more)

▼

Cette thèse sur travaux composée de quatre articles s’intéresse aux chaînes logistiques à deux échelons comportant un fournisseur en situation de monopole et de N clients dont les demandes pour un même produit sont corrélées. Les trois premiers articles étudient l’impact simultané des coopérations verticale et horizontale sur la performance globale. L’article 1 propose des extensions du modèle d’optimisation des stocks de Zhu et Thonemann (2004) en complétant notamment la coopération verticale entre le fournisseur et ses clients par une alliance horizontale et un échange d’informations entre clients. L’article 2 propose une modélisation multi-agents individu-centrée afin d’étudier l’impact sur la performance et la stabilité de la chaîne, de la diversité des comportements des clients face au risque et de leurs règles d’interaction dans le cadre d’une possible distorsion de l’information échangée. Nous proposons ensuite deux articles à visée plus applicative. L’article 3 s’intéresse à l’industrie pharmaceutique et étudie l’influence de la coopération entre grossistes-répartiteurs socialement responsables et leur laboratoire fournisseur pour réduire les surstocks et les gaspillages. L’article 4 consiste à comparer un pilotage centralisé à un pilotage décentralisé des stocks suite à un choc important de demande d’un produit alimentaire périssable. Les résultats de simulation font ressortir des conditions d’équilibre ainsi que des recommandations sur le pilotage global de ce type de chaînes. Plus généralement, cette thèse a permis de montrer l’intérêt d’une approche connexionniste de chaînes logistiques complexes avec agents hétérogènes s’échangeant de l’information.

AThis thesis is composed by two papers focusing on two-level supply chains with a monopoly supplier and N clients whose demands for the same products are correlated. The first paper studies the simultaneous impact of vertical and horizontal cooperation on the overall performance and the stability of the chain. It proposes an individual-centered multi-agents approach for studying the impact on performance of different kinds of customer behaviors associated with overstock risk and their interaction rules under possible distortion of the exchanged information. The second paper deals with pharmaceutical distribution and studies the influence of the cooperation between wholesale distributors and a unique supplier to reduce overstocks and wastes. More generally, this thesis has shown the relevance of a connectionist approach of complex supply chains with heterogeneous agents exchanging information.

Advisors/Committee Members: Thiel, Daniel (thesis director).

Subjects/Keywords: Systèmes multi-agents; Logistics chains

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APA (6^th Edition):

Berrada El Azizi, M. (2014). Modélisation multi-agents de la coopération au sein des chaînes logistiques à deux échelons : application à la distribution de produits pharmaceutiques au Maroc : Modeling cooperation in tow level's supply chain : a multi-agents approach. (Doctoral Dissertation). Paris 13. Retrieved from http://www.theses.fr/2014PA131020

Chicago Manual of Style (16^th Edition):

Berrada El Azizi, Mohamed. “Modélisation multi-agents de la coopération au sein des chaînes logistiques à deux échelons : application à la distribution de produits pharmaceutiques au Maroc : Modeling cooperation in tow level's supply chain : a multi-agents approach.” 2014. Doctoral Dissertation, Paris 13. Accessed January 19, 2021. http://www.theses.fr/2014PA131020.

MLA Handbook (7^th Edition):

Berrada El Azizi, Mohamed. “Modélisation multi-agents de la coopération au sein des chaînes logistiques à deux échelons : application à la distribution de produits pharmaceutiques au Maroc : Modeling cooperation in tow level's supply chain : a multi-agents approach.” 2014. Web. 19 Jan 2021.

Vancouver:

Berrada El Azizi M. Modélisation multi-agents de la coopération au sein des chaînes logistiques à deux échelons : application à la distribution de produits pharmaceutiques au Maroc : Modeling cooperation in tow level's supply chain : a multi-agents approach. [Internet] [Doctoral dissertation]. Paris 13; 2014. [cited 2021 Jan 19]. Available from: http://www.theses.fr/2014PA131020.

Council of Science Editors:

Berrada El Azizi M. Modélisation multi-agents de la coopération au sein des chaînes logistiques à deux échelons : application à la distribution de produits pharmaceutiques au Maroc : Modeling cooperation in tow level's supply chain : a multi-agents approach. [Doctoral Dissertation]. Paris 13; 2014. Available from: http://www.theses.fr/2014PA131020

University of Hong Kong

26. Choi, Pik-shan. Development of genotyping resistance testing of fusion inhibitors for anti-retroviral therapy.

Degree: 2008, University of Hong Kong

URL: http://hdl.handle.net/10722/52020

Subjects/Keywords: Antirheumatic Agents.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Choi, P. (2008). Development of genotyping resistance testing of fusion inhibitors for anti-retroviral therapy. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/52020

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Choi, Pik-shan. “Development of genotyping resistance testing of fusion inhibitors for anti-retroviral therapy.” 2008. Thesis, University of Hong Kong. Accessed January 19, 2021. http://hdl.handle.net/10722/52020.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Choi, Pik-shan. “Development of genotyping resistance testing of fusion inhibitors for anti-retroviral therapy.” 2008. Web. 19 Jan 2021.

Vancouver:

Choi P. Development of genotyping resistance testing of fusion inhibitors for anti-retroviral therapy. [Internet] [Thesis]. University of Hong Kong; 2008. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/10722/52020.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Choi P. Development of genotyping resistance testing of fusion inhibitors for anti-retroviral therapy. [Thesis]. University of Hong Kong; 2008. Available from: http://hdl.handle.net/10722/52020

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Hong Kong

27. Chan, Wai-kit. The most effective method to improve antiretroviral drug adherence.

Degree: 2008, University of Hong Kong

URL: http://hdl.handle.net/10722/54596

Subjects/Keywords: Antiretroviral agents.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chan, W. (2008). The most effective method to improve antiretroviral drug adherence. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/54596

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chan, Wai-kit. “The most effective method to improve antiretroviral drug adherence.” 2008. Thesis, University of Hong Kong. Accessed January 19, 2021. http://hdl.handle.net/10722/54596.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chan, Wai-kit. “The most effective method to improve antiretroviral drug adherence.” 2008. Web. 19 Jan 2021.

Vancouver:

Chan W. The most effective method to improve antiretroviral drug adherence. [Internet] [Thesis]. University of Hong Kong; 2008. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/10722/54596.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chan W. The most effective method to improve antiretroviral drug adherence. [Thesis]. University of Hong Kong; 2008. Available from: http://hdl.handle.net/10722/54596

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Tampere University

28. Talibov, Madar. Occupational Exposures and Risk of Adult Leukemia : A population-based study in the Nordic countries .

Degree: 2016, Tampere University

URL: https://trepo.tuni.fi/handle/10024/99875

► Leukemia veren valkosolujen syöpä. Sen neljä yleisintä muotoa ovat akuutti myelooinen leukemia (engl. lyhenne AML), akuutti lymfaattinen leukemia (ALL), krooninen myelooinen leukemia (CML) ja krooninen… (more)

▼ Leukemia veren valkosolujen syöpä. Sen neljä yleisintä muotoa ovat akuutti myelooinen leukemia (engl. lyhenne AML), akuutti lymfaattinen leukemia (ALL), krooninen myelooinen leukemia (CML) ja krooninen lymfaattinen leukemia (CLL). Vaikka monilla geneettisillä ja elintapoihin ja –ympäristöön liittyvillä tekijöillä on arvioitu olevan yhteyttä leukemian riskiin, useimmissa tapauksissa näyttö on epäyhtenäistä. Tutkimukseni tavoitteena oli arvioida eräiden ammattialtistusten yhteyttä aikuisten leukemiariskiin. Tutkimus pohjautuu pohjoismaisen ammattisyöpätutkimussarjan (Nordic Occupational Cancer Studies, NOCCA) yhteensä 14,9 miljoonan pohjoismaisen henkilön aineistoon. Näiden henkilöiden ammattitiedot 30-64 vuoden iässä ja tieto syöpään sairastumisesta vuoteen 2003-2005 asti saatiin kansallisista rekistereistä. Tutkimuksessa I verrattiin 53 ammattiluokan leukemiariskiä yleisen väestön leukemiariskiin (AML-tapaukset (n=18 811), CLL-tapaukset (n=20 462) ja muut leukemiatapaukset (n=15 570)). Tutkimuksessa II arvioitiin liuottimille altistumisen ja AML-riskin välistä yhteyttä ( 15 332 AML-tapausta ja 76 660 verrokkia) ja tutkimuksessa III erittäin matalataajuuksisen magneettikenttäaltistuksen ja sähköaltistuspiikkien määräarvioiden yhteyttä AML-riskiin (13 435 AML-tapausta ja 67 175 verrokkia). Tutkimuksessa IV verrattiin ryhmätason (NOCCA-JEM-niminen ammattialtistumatriisi) kosmiselle säteilylle altistumisen arvioita yksilökohtaisiin säteilymittaustietoihin, joita oli saatavissa Säteilyturvakeskuksesta (STUK) (1 535 lentäjää ja 3 487 matkustamohenkilökunnan jäsentä). Tutkimus osoitti leukemian ilmaantuvuuden olevan hieman väestökeskiarvoa suurempi eräissä ammattiluokissa. AML:n riski oli koholla autonkuljettajilla ja elintarviketyöntekijöillä ja CLL:n riski maanviljelijöillä ja konttorityöntekijöillä. Muiden leukemiatyyppien riski oli suurentunut merimiehillä, kemian prosessityöntekijöillä ja myyntiedustajilla. Metsureilla AML:n riski, merimiehillä AML:n ja CLL:n riskit, sekä kalastajilla muiden leukemiatyyppien riski, olivat tilastollisesti merkitsevästi tavanomaista pienempiä. AML:n riski ei liittynyt liuotinaltistuksiin eikä magneettikenttä- tai sähköaltistuksiin. Tutkimus osoitti myös, että kosmisen säteilyn altistusestimaatit poikkeavat toisistaan riippuen siitä, onko arvion lähteenä NOCCA-JEM (ryhmätason ammattialtistumatriisi) vai Säteilyturvakeskuksen mittausaineisto (yksilökohtaiset säteilymittaustiedot). Tutkimuksessa havaitut vaihtelut ammattialakohtaisessa leukemiailmaantuvuudessa olivat melko pieniä ja voisivat johtua työhön liittyvistä kemikaali- tai muista altistuksista. Havaintojemme mukaan ilmiön selittäjiä eivät ole liuotinaltistukset, magneettikentät eivätkä sähköaltistukset. Arvioitaessa lentohenkilökunnan altistumista kosmiselle säteilylle altistusarvioissa havaittiin selviä eroja NOCCA-JEM:n ja yksilöllisiin mittaustietoihin perustuvien arvioiden välillä.; Leukemia is a cancer of blood. Its four major types are acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), chronic myeloid…

Subjects/Keywords: leukemia ; occupation ; occupational agents ; exposure

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Talibov, M. (2016). Occupational Exposures and Risk of Adult Leukemia : A population-based study in the Nordic countries . (Doctoral Dissertation). Tampere University. Retrieved from https://trepo.tuni.fi/handle/10024/99875

Chicago Manual of Style (16^th Edition):

Talibov, Madar. “Occupational Exposures and Risk of Adult Leukemia : A population-based study in the Nordic countries .” 2016. Doctoral Dissertation, Tampere University. Accessed January 19, 2021. https://trepo.tuni.fi/handle/10024/99875.

MLA Handbook (7^th Edition):

Talibov, Madar. “Occupational Exposures and Risk of Adult Leukemia : A population-based study in the Nordic countries .” 2016. Web. 19 Jan 2021.

Vancouver:

Talibov M. Occupational Exposures and Risk of Adult Leukemia : A population-based study in the Nordic countries . [Internet] [Doctoral dissertation]. Tampere University; 2016. [cited 2021 Jan 19]. Available from: https://trepo.tuni.fi/handle/10024/99875.

Council of Science Editors:

Talibov M. Occupational Exposures and Risk of Adult Leukemia : A population-based study in the Nordic countries . [Doctoral Dissertation]. Tampere University; 2016. Available from: https://trepo.tuni.fi/handle/10024/99875

University of Utah

29. Koch, Michael. Mode of Action of Exocarpic Acid Against Mycobacterium Tuberculosis.

Degree: PhD, Pharmacology & Toxicology;, 2010, University of Utah

URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1458/rec/778

► Natural products continue to be a driving force in drug development, particularly for the treatment of infectious diseases. A stunning one third of the world's… (more)

▼ Natural products continue to be a driving force in drug development, particularly for the treatment of infectious diseases. A stunning one third of the world's population (2 billion individuals) is infected by Mycobacterium tuberculosis, the causative agents of pulmonary tuberculosis. While most of these cases are quiescent, about 8 million people suffer from active disease, resulting in a death toll of 2 million people annually worldwide. Exocarpic acid, a polyacetylenic fatty acid isolated from Exocarpos latifolia Santalacea R.Br., native to Papua New Guinea, has shown promising activity against Mycobacterium tuberculosis in vitro. Since several active exocarpic acid analogs were also found in Exocarpos extracts, the decision was made to develop exocarpic acid further as a pharmacophore. The central theme of this dissertation concerns the mechanism of action of exocarpic acid, since it needed to be elucidated before exocarpic acid can be further developed. Mechanistic lead information was developed through microarray data. Inhibition of fatty acid degradation, fatty acid biosynthesis, and amino acid starvation were the primary gene families induced. Physico-chemical consideration also suggested a potential effect on the mycobacterial cell membrane. Experiments designed to address these mechanisms revealed that exocarpic acid exhibits all the signs of a fatty acid biosynthesis system II inhibitor, without any recognizable effects on the mycobacterial membrane. In order to generate lead information for the next step in exocarpic acid drug development, several amide derivatives of exocarpic acid were synthesized. Some of these compounds showed acceptable activity against Mycobacterium tuberculosis without concomitant toxicity against eukaryotic cells. In order to provide initial quantitative structural activity data, a set of exocarpic acid analogs, which lack an unsaturated bond found in exocarpic acid, were also tested. These exhibited a wide array of mechanisms, indicating that the chain-length and unsaturated bond positions are crucial for activity against Mycobacterium tuberculosis. Exocarpic acid's conjugated double-bond acetylenic bond structure may therefore be a valuable pharmacophore for further development.

Subjects/Keywords: Mycobacterium tuberculosis; Antibacterial Agents

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APA (6^th Edition):

Koch, M. (2010). Mode of Action of Exocarpic Acid Against Mycobacterium Tuberculosis. (Doctoral Dissertation). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1458/rec/778

Chicago Manual of Style (16^th Edition):

Koch, Michael. “Mode of Action of Exocarpic Acid Against Mycobacterium Tuberculosis.” 2010. Doctoral Dissertation, University of Utah. Accessed January 19, 2021. http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1458/rec/778.

MLA Handbook (7^th Edition):

Koch, Michael. “Mode of Action of Exocarpic Acid Against Mycobacterium Tuberculosis.” 2010. Web. 19 Jan 2021.

Vancouver:

Koch M. Mode of Action of Exocarpic Acid Against Mycobacterium Tuberculosis. [Internet] [Doctoral dissertation]. University of Utah; 2010. [cited 2021 Jan 19]. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1458/rec/778.

Council of Science Editors:

Koch M. Mode of Action of Exocarpic Acid Against Mycobacterium Tuberculosis. [Doctoral Dissertation]. University of Utah; 2010. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1458/rec/778

30. Pandita, Renu Moti. SOME POTENTIAL ANTICANCER AGENTS FROM PLANTS WITH SPECIAL EMPHASIS ON ACACIA NILOTICA NARDOSTACHYS JATAMANSI AND CRYPTOLEPIS BUCHANANI; No.

Degree: Sciences, 2014, Guru Nanak Dev University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/23708

newline No

Summary:137-150, References:151-166

Advisors/Committee Members: Saxena, A.K..

Subjects/Keywords: ANTICANCER AGENTS

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APA (6^th Edition):

Pandita, R. M. (2014). SOME POTENTIAL ANTICANCER AGENTS FROM PLANTS WITH SPECIAL EMPHASIS ON ACACIA NILOTICA NARDOSTACHYS JATAMANSI AND CRYPTOLEPIS BUCHANANI; No. (Thesis). Guru Nanak Dev University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/23708

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Pandita, Renu Moti. “SOME POTENTIAL ANTICANCER AGENTS FROM PLANTS WITH SPECIAL EMPHASIS ON ACACIA NILOTICA NARDOSTACHYS JATAMANSI AND CRYPTOLEPIS BUCHANANI; No.” 2014. Thesis, Guru Nanak Dev University. Accessed January 19, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/23708.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Pandita, Renu Moti. “SOME POTENTIAL ANTICANCER AGENTS FROM PLANTS WITH SPECIAL EMPHASIS ON ACACIA NILOTICA NARDOSTACHYS JATAMANSI AND CRYPTOLEPIS BUCHANANI; No.” 2014. Web. 19 Jan 2021.

Vancouver:

Pandita RM. SOME POTENTIAL ANTICANCER AGENTS FROM PLANTS WITH SPECIAL EMPHASIS ON ACACIA NILOTICA NARDOSTACHYS JATAMANSI AND CRYPTOLEPIS BUCHANANI; No. [Internet] [Thesis]. Guru Nanak Dev University; 2014. [cited 2021 Jan 19]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/23708.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pandita RM. SOME POTENTIAL ANTICANCER AGENTS FROM PLANTS WITH SPECIAL EMPHASIS ON ACACIA NILOTICA NARDOSTACHYS JATAMANSI AND CRYPTOLEPIS BUCHANANI; No. [Thesis]. Guru Nanak Dev University; 2014. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/23708

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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Open Access Theses and Dissertations