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Clemson University
1.
Trapp, Olivia Tant.
Determining Indicators of Successful Aging in a Population of Individuals Living in an Active-Living Community.
Degree: MS, Food Science and Human Nutrition, 2020, Clemson University
URL: https://tigerprints.clemson.edu/all_theses/3419
► In the United States, the older population in consistently growing, with 17.7% of adults over the age of 65 in South Carolina alone. As…
(more)
▼ In the United States, the older population in consistently growing, with 17.7% of adults over the age of 65 in South Carolina alone. As aging populations grow, research must examine factors linked to longevity and extended quality of life, as well as facts in both middle and later life that are associated with higher levels of successful aging (SA). This study examined the relationship between the Community Health Activities Model Program (CHAMPS) or the Health-Promoting Lifestyle Profile (HPLP II) and fourteen selected markers of health and SA. Anthropometric data (including bodyweight, height, blood pressure, grip strength, body mass index, body composition, waist circumference, hip circumference, SPO2, mid-arm muscle circumference and pulse) was collected from participants over the age of 45 at three time points over a 12-week period. Statistical analysis showed that higher levels of activity in older adults were associated with a number of improved health markers including increased lean body mass and decreased waist circumference. This supported the idea that individuals living in an active living community who engage in the more developed built environment and resources for physical activity have a number of indicators associated with successful aging. The physiological indicators measured, and the questionnaire responses provided suggest that access to a safe, available built environment that promotes physical activity could be of benefit to all individuals as they age to promote the attainment of successful aging.
Advisors/Committee Members: Vivian Haley-Zitlin, Margaret Condrasky, William Bridges.
Subjects/Keywords: active-living; ageing; healthy aging; Successful Aging
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APA (6th Edition):
Trapp, O. T. (2020). Determining Indicators of Successful Aging in a Population of Individuals Living in an Active-Living Community. (Masters Thesis). Clemson University. Retrieved from https://tigerprints.clemson.edu/all_theses/3419
Chicago Manual of Style (16th Edition):
Trapp, Olivia Tant. “Determining Indicators of Successful Aging in a Population of Individuals Living in an Active-Living Community.” 2020. Masters Thesis, Clemson University. Accessed April 10, 2021.
https://tigerprints.clemson.edu/all_theses/3419.
MLA Handbook (7th Edition):
Trapp, Olivia Tant. “Determining Indicators of Successful Aging in a Population of Individuals Living in an Active-Living Community.” 2020. Web. 10 Apr 2021.
Vancouver:
Trapp OT. Determining Indicators of Successful Aging in a Population of Individuals Living in an Active-Living Community. [Internet] [Masters thesis]. Clemson University; 2020. [cited 2021 Apr 10].
Available from: https://tigerprints.clemson.edu/all_theses/3419.
Council of Science Editors:
Trapp OT. Determining Indicators of Successful Aging in a Population of Individuals Living in an Active-Living Community. [Masters Thesis]. Clemson University; 2020. Available from: https://tigerprints.clemson.edu/all_theses/3419

University of Edinburgh
2.
Miller, Sophie.
Aging and decision making.
Degree: 2010, University of Edinburgh
URL: http://hdl.handle.net/1842/4940
► The study sought to clarify the effects of aging in regard to decision making abilities. Decision making is dependent upon the Frontal Cortex structures; the…
(more)
▼ The study sought to clarify the effects of aging in regard to decision making abilities. Decision making is dependent upon the Frontal Cortex structures; the Orbitofrontal Cortex and the Dorsolateral Prefrontal Cortex. These structures are thought to decline with age, and so functioning of these areas important for decision making is also thought to deteriorate. Structural deterioration of the Frontal Cortex is often regarded as disproportionate.
An objective of the current study was to compare the functioning involved in decision making of an older group of participants to that of Orbitofrontal Cortex lesion patients and Dosolateral Prefrontal Cortex lesion patients, and therefore ascertain which lesion patients the older participants of the current study performed most similarly to.
To do this three decision making tasks were implemented which included the Original Iowa Gambling Task, the Variant Iowa Gambling Task and the Reversal Learning Task. All tasks tested the decision making abilities of participants attributed to the functioning of the Orbitofrontal Cortex and the Dorsolateral Prefrontal Cortex. A two way analysis of variance was carried out on both Iowa Gambling Tasks, whilst a repeated measures analysis of variance was also completed for both tasks. Independent t-tests were implemented in the Reversal Learning Task.
The study showed an impairment of the older group on both Iowa Gambling Tasks when compared to the younger control group. Impairment on the Original Iowa Gambling Task suggested a possible impairment of the Orbitofrontal Cortex but this was not reflected in the Reversal Learning Task. Impairment on both the Iowa Gambling Tasks indicated that older participants performed most similarly to Dorsolateral Prefrontal Cortex lesion patients. Consequently, the functioning of the Dorsolateral Prefrontal Cortex in older participants looks to have declined more rapidly than the functioning of the Orbitofrontal Cortex.
Advisors/Committee Members: Abrahams, Sharon.
Subjects/Keywords: Aging
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Miller, S. (2010). Aging and decision making. (Thesis). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/4940
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Miller, Sophie. “Aging and decision making.” 2010. Thesis, University of Edinburgh. Accessed April 10, 2021.
http://hdl.handle.net/1842/4940.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Miller, Sophie. “Aging and decision making.” 2010. Web. 10 Apr 2021.
Vancouver:
Miller S. Aging and decision making. [Internet] [Thesis]. University of Edinburgh; 2010. [cited 2021 Apr 10].
Available from: http://hdl.handle.net/1842/4940.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Miller S. Aging and decision making. [Thesis]. University of Edinburgh; 2010. Available from: http://hdl.handle.net/1842/4940
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Tulane University
3.
Voglewede, Rebecca.
Reduced sensory-evoked plasticity in the aging barrel cortex.
Degree: 2018, Tulane University
URL: https://digitallibrary.tulane.edu/islandora/object/tulane:87839
► [email protected]
To learn and form memories, synapses must maintain both the flexibility to adapt in new scenarios and the stability to preserve integrity of the…
(more)
▼ [email protected]
To learn and form memories, synapses must maintain both the flexibility to adapt in new scenarios and the stability to preserve integrity of the neural circuits associated with those memories. Impairments in synaptic connectivity have been linked to cognitive deficits in both a variety of disorders and in healthy aging. However, the anatomical and structural bases of this impairment have not been identified yet. A hallmark of neural plasticity in young adults is short-term synaptic rearrangement, yet aged animals already display higher synaptic turnover rates at baseline. Using two-photon excitation (2PE) microscopy, we explored if this elevated turnover alters the aged brain’s response to a sensory plasticity-inducing scenario by examining dendritic spine behavior in the tuft of layer V pyramidal neurons of primary somatosensory cortex. Following a sensory-evoked plasticity protocol involving whisker stimulation, aged mice displayed a reduction in spine dynamics (gain, loss, and turnover), decreased spine clustering, lower spine stability, and a spine morphological phenotype of synaptic weakening when compared to young adult mice. These results suggest a deficiency of the cortical neurons of aged mice to structurally incorporate new sensory experiences, in the form of clustered, long-lasting synapses, into already existing cortical circuits. This research provides the first evidence linking experience-dependent plasticity with in vivo spine dynamics in the aged brain and supports a model of both reduced synaptic plasticity and reduced synaptic tenacity in the aged somatosensory system. This thesis contributes to an understanding of information processing deficits in the aged brain with a focus on aberrant plasticity of synapses in the distal apical tuft and ways distal tuft plasticity may be modified.
1
Rebecca Lynn Voglewede
Advisors/Committee Members: (author), Mostany, Ricardo (Thesis advisor), (Thesis advisor), School of Science & Engineering Neuroscience (Degree granting institution), NULL (Degree granting institution).
Subjects/Keywords: aging
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Voglewede, R. (2018). Reduced sensory-evoked plasticity in the aging barrel cortex. (Thesis). Tulane University. Retrieved from https://digitallibrary.tulane.edu/islandora/object/tulane:87839
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Voglewede, Rebecca. “Reduced sensory-evoked plasticity in the aging barrel cortex.” 2018. Thesis, Tulane University. Accessed April 10, 2021.
https://digitallibrary.tulane.edu/islandora/object/tulane:87839.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Voglewede, Rebecca. “Reduced sensory-evoked plasticity in the aging barrel cortex.” 2018. Web. 10 Apr 2021.
Vancouver:
Voglewede R. Reduced sensory-evoked plasticity in the aging barrel cortex. [Internet] [Thesis]. Tulane University; 2018. [cited 2021 Apr 10].
Available from: https://digitallibrary.tulane.edu/islandora/object/tulane:87839.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Voglewede R. Reduced sensory-evoked plasticity in the aging barrel cortex. [Thesis]. Tulane University; 2018. Available from: https://digitallibrary.tulane.edu/islandora/object/tulane:87839
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
4.
Trini, Afsana Bahar.
Effect of Aging on Adiposity and Metabolic Flexibility in Male Rats and the Modulatory Role of Subcutaneous White Adipose Tissue Thermogenesis.
Degree: 2020, University of the Sciences in Philadelphia
URL: http://pqdtopen.proquest.com/#viewpdf?dispub=27663597
► Twelve-month-old male Sprague-Dawley rats exhibited a marked increase in percent adiposity and percent epididymal fat pad weight compared to their 2-month-old littermates. Aging was accompanied…
(more)
▼ Twelve-month-old male Sprague-Dawley rats exhibited a marked increase in percent adiposity and percent epididymal fat pad weight compared to their 2-month-old littermates. Aging was accompanied by deteriorated metabolic flexibility including decreased insulin sensitivity to glucose metabolism and increased hepatic lipid deposition. The alterations in adiposity and metabolic flexibility can be due to increased energy intake and/or decreased energy expenditure. Therefore, our first objective was to evaluate the status of energy intake and voluntary and involuntary energy expenditure in the animals. Our results show that food intake and voluntary energy expenditure as measured by locomotor activity were not responsible for the age-induced adiposity. Increased feed efficiency and decreased core body temperature in 12-month-old animals suggested that a reduction in resting metabolic rate (RMR) was responsible for their adiposity. Adaptive thermogenesis is an important component of RMR. We observed decreased mRNA levels of the major thermogenic gene, UCP1 in the brown adipose tissue (BAT) of 12-month-old animals that confirmed literature reports of decreased BAT mediated thermogenesis with age. Recently, subcutaneous white adipose tissue (sWAT) has also been shown to engage in thermogenesis though its contribution to energy expenditure and age mediated adiposity has not been investigated in detail. We hypothesized that decreases in inguinal WAT (IWAT) mediated thermogenesis contributes to the increased adiposity in 12-month-old animals. The next objective of our studies was to explore each step in the pathway of IWAT mediated thermogenesis including sympathetic nervous system (SNS) tone, SNS mediated lipolysis, fatty acid oxidation, mitochondrial biogenesis, and mitochondrial function in 2-month and 12-month-old male Sprague-Dawley rats. We observed decreases in β2-adrenergic receptor mRNA levels and adenylate cyclase activity in 12-month-old animals indicating that aging caused a decline in intracellular SNS tone in IWAT. Decreased SNS tone produced a decrease in the mRNA levels of its downstream target, the rate limiting lipolytic enzyme, hormone sensitive lipase but no change in the expression of the critical fatty acid oxidation gene, CPT1b. Twelve month old animals exhibited decreased mRNA levels of the master regulator of mitochondrial biogenesis, PGC1α, and decreased activity of citrate synthase, a marker of mitochondrial density. Accompanying these decreases in mitochondrial biogenesis was a decrease in mitochondrial function as evidenced by decreased mRNA levels of COX4i1, a marker of mitochondrial oxidative capacity and decreased activity of cytochrome c oxidase, a marker of complex IV activity in the electron transport chain. Finally, twelve month old animals exhibited decreased mitochondrial thermogenic capacity as evidenced by decreased mRNA and protein levels of UCP1. Twelve month animals also exhibited decrease in the complementary thyroid axis mediated thermogenesis evidenced in decreases in plasma levels…
Subjects/Keywords: Aging
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Trini, A. B. (2020). Effect of Aging on Adiposity and Metabolic Flexibility in Male Rats and the Modulatory Role of Subcutaneous White Adipose Tissue Thermogenesis. (Thesis). University of the Sciences in Philadelphia. Retrieved from http://pqdtopen.proquest.com/#viewpdf?dispub=27663597
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Trini, Afsana Bahar. “Effect of Aging on Adiposity and Metabolic Flexibility in Male Rats and the Modulatory Role of Subcutaneous White Adipose Tissue Thermogenesis.” 2020. Thesis, University of the Sciences in Philadelphia. Accessed April 10, 2021.
http://pqdtopen.proquest.com/#viewpdf?dispub=27663597.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Trini, Afsana Bahar. “Effect of Aging on Adiposity and Metabolic Flexibility in Male Rats and the Modulatory Role of Subcutaneous White Adipose Tissue Thermogenesis.” 2020. Web. 10 Apr 2021.
Vancouver:
Trini AB. Effect of Aging on Adiposity and Metabolic Flexibility in Male Rats and the Modulatory Role of Subcutaneous White Adipose Tissue Thermogenesis. [Internet] [Thesis]. University of the Sciences in Philadelphia; 2020. [cited 2021 Apr 10].
Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=27663597.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Trini AB. Effect of Aging on Adiposity and Metabolic Flexibility in Male Rats and the Modulatory Role of Subcutaneous White Adipose Tissue Thermogenesis. [Thesis]. University of the Sciences in Philadelphia; 2020. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=27663597
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Harvard University
5.
Stroustrup, Nicholas Edward.
The C. elegans Lifespan Machine and its application to the temperature scaling of lifespan.
Degree: PhD, Systems Biology, 2013, Harvard University
URL: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11158238
► Lifespan results from the complex interaction between genetic, environmental and stochastic factors, and therefore varies widely even among isogenic individuals. In C. elegans , the…
(more)
▼ Lifespan results from the complex interaction between genetic, environmental and stochastic factors, and therefore varies widely even among isogenic individuals. In C. elegans , the action of molecular mechanisms on aging can be inferred from their statistical effects on the distribution of lifespans within populations. However, such investigations are hindered by limitations in the methods available for collecting lifespan data. To enable the rapid collection of survival curves at any desired statistical resolution, we developed an automated platform for determining the lifespans of large populations of nematodes.
Advisors/Committee Members: Fontana, Walter (advisor), Murray, Andrew (committee member), Kishony, Roy (committee member), Ruvkun, Gary (committee member), Slack, Frank (committee member).
Subjects/Keywords: Aging
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Stroustrup, N. E. (2013). The C. elegans Lifespan Machine and its application to the temperature scaling of lifespan. (Doctoral Dissertation). Harvard University. Retrieved from http://nrs.harvard.edu/urn-3:HUL.InstRepos:11158238
Chicago Manual of Style (16th Edition):
Stroustrup, Nicholas Edward. “The C. elegans Lifespan Machine and its application to the temperature scaling of lifespan.” 2013. Doctoral Dissertation, Harvard University. Accessed April 10, 2021.
http://nrs.harvard.edu/urn-3:HUL.InstRepos:11158238.
MLA Handbook (7th Edition):
Stroustrup, Nicholas Edward. “The C. elegans Lifespan Machine and its application to the temperature scaling of lifespan.” 2013. Web. 10 Apr 2021.
Vancouver:
Stroustrup NE. The C. elegans Lifespan Machine and its application to the temperature scaling of lifespan. [Internet] [Doctoral dissertation]. Harvard University; 2013. [cited 2021 Apr 10].
Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11158238.
Council of Science Editors:
Stroustrup NE. The C. elegans Lifespan Machine and its application to the temperature scaling of lifespan. [Doctoral Dissertation]. Harvard University; 2013. Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11158238

Wake Forest University
6.
Hicks, Amy.
THE EFFECTS OF NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE 2 (NMNAT2) ON MOUSE NERVE AND BLADDER DEVELOPMENT.
Degree: 2012, Wake Forest University
URL: http://hdl.handle.net/10339/37673
► Programmed cell death is one important component of neurodevelopment that, until recently, was thought to be a passive process based upon the lack of trophic…
(more)
▼ Programmed cell death is one important component of neurodevelopment that, until recently, was thought to be a passive process based upon the lack of trophic support. There is now data that supports the compartmentalized neuron loss theory where each compartment of a nerve cell has a distinct mechanism of maintenance and death. In axons, the Wlds protein is the most widely studied for its ability to delay Wallerian degeneration. Studies have linked the Nmnat1 portion of the Wlds fusion protein to the majority of its ability to protect axons, but recent work has identified Nmnat2 as the endogenous factor involved in axon maintenance. Our goal is to identify the effects that Nmnat2 has on normal development. In this study, a randomly generated mutant was identified with a full knock-out of the Nmnat2 gene and a grossly distended bladder named Bloated Bladder (Blad). Morphological analysis of the Blad mutants showed systemic effects that are all characteristic of an embryo that is paralyzed in utero. The brain itself appeared normal, but motoneuron and sensory neurons were significantly reduced at embryonic day 18.5 (E18.5). Analysis of NF+ peripheral nerves in the hind limb identified a distal-to-proximal pattern of axonal degeneration. Interestingly, the heterozygote population was indistinguishable from the wild-type animals in this portion of the study, even with a 50-75% reduction in Nmnat2 expression. When taking a closer look at the bladder, the bladder starts to show signs of developmental differences at E15.5 in the Blad mutants, but the bladder wall appears to mature and develop the appropriate neuroreceptors even in the absence of functional innervation. There were some interesting trends of reduced muscle strength and activity in a pilot study comparing heterozygotes to wild littermates, but none of the trends appeared to be progressive, and there were not enough animals to make any definitive deductions. In conclusion, Nmnat2 is involved in peripheral axon maintenance during development.
Subjects/Keywords: Aging
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Hicks, A. (2012). THE EFFECTS OF NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE 2 (NMNAT2) ON MOUSE NERVE AND BLADDER DEVELOPMENT. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/37673
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Hicks, Amy. “THE EFFECTS OF NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE 2 (NMNAT2) ON MOUSE NERVE AND BLADDER DEVELOPMENT.” 2012. Thesis, Wake Forest University. Accessed April 10, 2021.
http://hdl.handle.net/10339/37673.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Hicks, Amy. “THE EFFECTS OF NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE 2 (NMNAT2) ON MOUSE NERVE AND BLADDER DEVELOPMENT.” 2012. Web. 10 Apr 2021.
Vancouver:
Hicks A. THE EFFECTS OF NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE 2 (NMNAT2) ON MOUSE NERVE AND BLADDER DEVELOPMENT. [Internet] [Thesis]. Wake Forest University; 2012. [cited 2021 Apr 10].
Available from: http://hdl.handle.net/10339/37673.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Hicks A. THE EFFECTS OF NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE 2 (NMNAT2) ON MOUSE NERVE AND BLADDER DEVELOPMENT. [Thesis]. Wake Forest University; 2012. Available from: http://hdl.handle.net/10339/37673
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Wake Forest University
7.
Moussa, Malaak.
THE EFFECTS OF SOCIAL DRINKING IN OLDER AGE ON COGNITION AND BRAIN HEALTH.
Degree: 2015, Wake Forest University
URL: http://hdl.handle.net/10339/57165
► Recent census data has found that roughly 40% of adults 65 years and older not only consume alcohol but also drink more of it than…
(more)
▼ Recent census data has found that roughly 40% of adults 65 years and older not only consume alcohol but also drink more of it than previous generations. Older drinkers are more sensitive than younger counterparts to the psychoactive effects of alcohol due to natural biological changes that occur with aging, and this may leave them vulnerable to even moderate amounts of alcohol consumption. The focus of this dissertation is on non-problem social alcohol consumption (7-21 drinks per week) in older age (≥ 65 years old), and the overarching goal was to determine whether or not it is associated with exacerbated age-related cognitive decline and brain changes.
Subjects/Keywords: Aging
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Moussa, M. (2015). THE EFFECTS OF SOCIAL DRINKING IN OLDER AGE ON COGNITION AND BRAIN HEALTH. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/57165
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Moussa, Malaak. “THE EFFECTS OF SOCIAL DRINKING IN OLDER AGE ON COGNITION AND BRAIN HEALTH.” 2015. Thesis, Wake Forest University. Accessed April 10, 2021.
http://hdl.handle.net/10339/57165.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Moussa, Malaak. “THE EFFECTS OF SOCIAL DRINKING IN OLDER AGE ON COGNITION AND BRAIN HEALTH.” 2015. Web. 10 Apr 2021.
Vancouver:
Moussa M. THE EFFECTS OF SOCIAL DRINKING IN OLDER AGE ON COGNITION AND BRAIN HEALTH. [Internet] [Thesis]. Wake Forest University; 2015. [cited 2021 Apr 10].
Available from: http://hdl.handle.net/10339/57165.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Moussa M. THE EFFECTS OF SOCIAL DRINKING IN OLDER AGE ON COGNITION AND BRAIN HEALTH. [Thesis]. Wake Forest University; 2015. Available from: http://hdl.handle.net/10339/57165
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
8.
Raffield, Laura Marie Tonks.
Analysis of the genetic and epidemiological contributors to aging-related traits in the Diabetes Heart Study.
Degree: 2015, Wake Forest University
URL: http://hdl.handle.net/10339/57250
► Type 2 diabetes (T2D), a disease which affects more than 25% of adults over age 65 in the United States, is characterized by persistent elevations…
(more)
▼ Type 2 diabetes (T2D), a disease which affects more than 25% of adults over age 65 in the United States, is characterized by persistent elevations in blood glucose due to lower insulin production and elevated resistance to insulin’s actions in the peripheral tissues. T2D increases risk for a number of age-related comorbidities, including cardiovascular disease and cognitive decline. Risk of these comorbidities is thought to be influenced by both clinical factors, including differences in treatment, lifestyle, and environment, and genetic risk factors. This dissertation explores a number of potential contributors to these comorbidities in the family-based, T2D enriched Diabetes Heart Study cohort.
Subjects/Keywords: aging
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Raffield, L. M. T. (2015). Analysis of the genetic and epidemiological contributors to aging-related traits in the Diabetes Heart Study. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/57250
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Raffield, Laura Marie Tonks. “Analysis of the genetic and epidemiological contributors to aging-related traits in the Diabetes Heart Study.” 2015. Thesis, Wake Forest University. Accessed April 10, 2021.
http://hdl.handle.net/10339/57250.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Raffield, Laura Marie Tonks. “Analysis of the genetic and epidemiological contributors to aging-related traits in the Diabetes Heart Study.” 2015. Web. 10 Apr 2021.
Vancouver:
Raffield LMT. Analysis of the genetic and epidemiological contributors to aging-related traits in the Diabetes Heart Study. [Internet] [Thesis]. Wake Forest University; 2015. [cited 2021 Apr 10].
Available from: http://hdl.handle.net/10339/57250.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Raffield LMT. Analysis of the genetic and epidemiological contributors to aging-related traits in the Diabetes Heart Study. [Thesis]. Wake Forest University; 2015. Available from: http://hdl.handle.net/10339/57250
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Wake Forest University
9.
Schoell, Samantha.
Development of Finite Element Models of the Aging Population using Model Morphing Techniques.
Degree: 2017, Wake Forest University
URL: http://hdl.handle.net/10339/82175
► Elderly adults aged 65 years and older are a vulnerable population with a greater risk of injury and injury-related deaths due to morphological and physiological…
(more)
▼ Elderly adults aged 65 years and older are a vulnerable population with a greater risk of injury and injury-related deaths due to morphological and physiological changes with age. The elderly population constitutes more than 13% of the total population and with increases in life expectancy, the elderly population is projected to account for nearly 20% of the population by 2030. In addition to the growing elderly population, it is also projected by 2030 that half of these elderly adults will also be obese. Increases in fragility and frailty in the aging and obese population can be the result of morphologic, compositional, and material changes in the human body with age. These changes in the human body also can be the result of osteoporosis, which is a significant public health concern and may be exacerbated with weight loss. Current tools to assess injury and fracture risk generally do not account for the variation in morphology, composition, and material changes with age. This study aims to develop and validate age and sex-specific and subject-specific finite element (FE) human body models to accurately model morphology and mechanics for the elderly and obese populations.
Subjects/Keywords: Aging
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APA (6th Edition):
Schoell, S. (2017). Development of Finite Element Models of the Aging Population using Model Morphing Techniques. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/82175
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Schoell, Samantha. “Development of Finite Element Models of the Aging Population using Model Morphing Techniques.” 2017. Thesis, Wake Forest University. Accessed April 10, 2021.
http://hdl.handle.net/10339/82175.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Schoell, Samantha. “Development of Finite Element Models of the Aging Population using Model Morphing Techniques.” 2017. Web. 10 Apr 2021.
Vancouver:
Schoell S. Development of Finite Element Models of the Aging Population using Model Morphing Techniques. [Internet] [Thesis]. Wake Forest University; 2017. [cited 2021 Apr 10].
Available from: http://hdl.handle.net/10339/82175.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Schoell S. Development of Finite Element Models of the Aging Population using Model Morphing Techniques. [Thesis]. Wake Forest University; 2017. Available from: http://hdl.handle.net/10339/82175
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Florida State University
10.
Glasgow, Katherine Lynn.
Care Receipt and Care Provision in Parent-Adult Child Relationships: Their Association with Older Adults' Mental Health.
Degree: PhD, Sociology, 2018, Florida State University
URL: http://purl.flvc.org/fsu/fd/2018_Su_Glasgow_fsu_0071E_14596
;
► Unprecedented shifts in age structure has important implications for the number of people ages 65 and older living with disabilities and requiring long-term care. Further,…
(more)
▼ Unprecedented shifts in age structure has important implications for the number of people ages 65 and older living with disabilities and requiring long-term care. Further, health care trends, including the early discharge of hospital patients and the transition of Medicaid funds away from nursing home care to community-based care (Stillman and Black 2005), has resulted in increasing numbers of older adults relying on assistance from family, especially adult children (Freedman and Spillman 2014). While it is known that adult children play an instrumental role in caring for their aging parents, relatively little is known about how this arrangement impacts the well-being of the parent. Using data from the 2010 Health and Retirement Study, this dissertation examines care receipt and care provision among functionally limited older adults and their adult children, as well as their associations with mental health. Unlike previous research examining care (receipt and provision) between older adults and their adult children, this study pays greater attention to potential gender differences in the type of care given or received, as well as their associations with mental health. In my first analysis I use logistic regression analysis to examine how sociodemographic, socioeconomic, and health factors affect the likelihood of giving and receiving various types of care. Results examining care receipt revealed that parents who are most in need of care – for example, women, race/ethnic minorities, and those with fewer socioeconomic resources and poorer health – are also more likely to receive it from their adult children. Results examining care provision revealed that parents with greater socioeconomic resources were most likely to provide financial support to adult children, while women, non-Hispanic Blacks and non-married parents were more likely to provide delayed care provision, including a will/trust or life insurance benefit. In my second set of analyses address I use negative binomial regression to examine how care (receipt and provision) are associated with mental health. I also examine how associations between care (receipt and provision) and mental health vary by gender and by level of functional limitation. Results for care receipt reveal that receiving help with IADLs is associated with better mental health and that this association is stronger for women and for those with greater functional limitations. Results for care provision reveal that including a child in a will or as a life insurance beneficiary was associated with better mental health, on average. In contrast, providing financial support to adult children was associated with worse mental health for women and those with more functional limitations. This study underscores the importance of examining specific types of care received and given and highlights the importance of considering the gender of care recipients when examining the association between care and mental health.
A Dissertation submitted to the Department of Sociology in partial fulfillment of the…
Advisors/Committee Members: Anne E. Barrett (professor directing dissertation), Ming Cui (university representative), Miles G. Taylor (committee member), John Taylor (committee member).
Subjects/Keywords: Aging
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Glasgow, K. L. (2018). Care Receipt and Care Provision in Parent-Adult Child Relationships: Their Association with Older Adults' Mental Health. (Doctoral Dissertation). Florida State University. Retrieved from http://purl.flvc.org/fsu/fd/2018_Su_Glasgow_fsu_0071E_14596 ;
Chicago Manual of Style (16th Edition):
Glasgow, Katherine Lynn. “Care Receipt and Care Provision in Parent-Adult Child Relationships: Their Association with Older Adults' Mental Health.” 2018. Doctoral Dissertation, Florida State University. Accessed April 10, 2021.
http://purl.flvc.org/fsu/fd/2018_Su_Glasgow_fsu_0071E_14596 ;.
MLA Handbook (7th Edition):
Glasgow, Katherine Lynn. “Care Receipt and Care Provision in Parent-Adult Child Relationships: Their Association with Older Adults' Mental Health.” 2018. Web. 10 Apr 2021.
Vancouver:
Glasgow KL. Care Receipt and Care Provision in Parent-Adult Child Relationships: Their Association with Older Adults' Mental Health. [Internet] [Doctoral dissertation]. Florida State University; 2018. [cited 2021 Apr 10].
Available from: http://purl.flvc.org/fsu/fd/2018_Su_Glasgow_fsu_0071E_14596 ;.
Council of Science Editors:
Glasgow KL. Care Receipt and Care Provision in Parent-Adult Child Relationships: Their Association with Older Adults' Mental Health. [Doctoral Dissertation]. Florida State University; 2018. Available from: http://purl.flvc.org/fsu/fd/2018_Su_Glasgow_fsu_0071E_14596 ;

Boston University
11.
Huang, Grace.
Surgical menopause and frailty risk in older community dwelling women: the study of osteoporotic fractures.
Degree: MS, Epidemiology, 2016, Boston University
URL: http://hdl.handle.net/2144/19528
► BACKGROUND: Low testosterone levels in older women have been shown to be associated with frailty. Whether older postmenopausal women with a history of bilateral oophorectomy…
(more)
▼ BACKGROUND: Low testosterone levels in older women have been shown to be associated with frailty. Whether older postmenopausal women with a history of bilateral oophorectomy before natural menopause resulting in lower testosterone levels (surgical menopause) have higher risk for frailty is not known. This prospective study investigated whether women who had surgically-induced menopause had a greater risk of frailty than naturally menopausal women. Furthermore, we also determined whether lower serum testosterone levels would be associated with frailty in our study population of older postmenopausal women.
METHODS: The sample included 7699 community-dwelling white women aged ≥ 65 years from the Study of Osteoporotic Fractures (SOF). Participants were determined to have undergone surgical versus natural menopause based on whether or not they reported retrospectively having undergone a bilateral oophorectomy before or after menopause. Frailty status was classified as not frail, somewhat frail (hereafter referred to as Intermediate stage), frail or death at four interviews, conducted 6-18 years post-baseline. Baseline serum total testosterone concentrations were available on a subset of 541 participants.
RESULTS: Approximately 12.6% of the participants reported surgical menopause. A total of 39.7% were classified as somewhat frail (intermediate stage) and 10.1% as frail. Twenty-two (22.0%) of the participants died during the interview period when frailty was assessed. Mean age at baseline was 71.2 years. Total serum testosterone levels were significantly lower among surgically menopausal women compared to naturally menopausal women (p<0.01). Surgical menopause was not significantly associated with an increased risk of frailty (Odds Ratio=0.94; 95% CI=0.72-1.22), intermediate stage frailty (Odds Ratio=0.96; 95% CI=0.80-1.10) or death (Odds Ratio=1.17 ; 95% CI=0.97-1.42) after adjusting for age, BMI and number of IADL impairments. Stratified analyses showed that oral estrogen use did not modify these associations.
CONCLUSION: Among postmenopausal women, surgical menopause was not associated with a higher risk for frailty compared to naturally menopausal women, even in the absence of estrogen therapy. Future prospective studies are needed to investigate hormonal mechanisms involved in the development of frailty in older postmenopausal women.
Subjects/Keywords: Aging
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Huang, G. (2016). Surgical menopause and frailty risk in older community dwelling women: the study of osteoporotic fractures. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/19528
Chicago Manual of Style (16th Edition):
Huang, Grace. “Surgical menopause and frailty risk in older community dwelling women: the study of osteoporotic fractures.” 2016. Masters Thesis, Boston University. Accessed April 10, 2021.
http://hdl.handle.net/2144/19528.
MLA Handbook (7th Edition):
Huang, Grace. “Surgical menopause and frailty risk in older community dwelling women: the study of osteoporotic fractures.” 2016. Web. 10 Apr 2021.
Vancouver:
Huang G. Surgical menopause and frailty risk in older community dwelling women: the study of osteoporotic fractures. [Internet] [Masters thesis]. Boston University; 2016. [cited 2021 Apr 10].
Available from: http://hdl.handle.net/2144/19528.
Council of Science Editors:
Huang G. Surgical menopause and frailty risk in older community dwelling women: the study of osteoporotic fractures. [Masters Thesis]. Boston University; 2016. Available from: http://hdl.handle.net/2144/19528

University of Manitoba
12.
Slaght, Jana.
Walking cadence: A novel strategy to improve the proportion of inactive older adults who reach the Canadian Physical Activity Guidelines.
Degree: Kinesiology and Recreation Management, 2015, University of Manitoba
URL: http://hdl.handle.net/1993/30664
► Problem: Only 13% of older adults reach the Canadian Physical Activity Guidelines (CPAG) aerobic activity recommendations. Walking cadence (steps per minute) is a strategy proposed…
(more)
▼ Problem: Only 13% of older adults reach the Canadian Physical Activity Guidelines (CPAG) aerobic activity recommendations. Walking cadence (steps per minute) is a strategy proposed to increase walking at the intensity recommended by the CPAG.
Methods: Inactive older adults (N = 51) were instructed to walk 150 minutes per week at no specified intensity during phase 1 (6 weeks). In phase 2 (6 weeks), duration was maintained but the group one (N = 23) received instructions on how to reach moderate intensity, using a pedometer and individualized walking cadence, while group two (N = 22) did not.
Results: During phase 1, MVPA time and MVPA in 10-minute bouts increased (p ≤ 0.05), and in phase 2 group one continued to increase MVPA time and time in MVPA in 10-minute bouts (p ≤ 0.01), while the group two significantly decreased (p ≤ 0.01).
Discussion: Previously inactive older adults can improve time in MVPA in 10-minute bouts, as recommended by the CPAG, by using prescribed walking cadence, a pedometer to track moderate intensity, and practicing walking at this cadence.
Advisors/Committee Members: Bouchard, Danielle (Kinesiology and Recreation Management) (supervisor), Giesbrecht, Gordon (Kinesiology and Recreation Management) .
Subjects/Keywords: Aging
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Slaght, J. (2015). Walking cadence: A novel strategy to improve the proportion of inactive older adults who reach the Canadian Physical Activity Guidelines. (Masters Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/30664
Chicago Manual of Style (16th Edition):
Slaght, Jana. “Walking cadence: A novel strategy to improve the proportion of inactive older adults who reach the Canadian Physical Activity Guidelines.” 2015. Masters Thesis, University of Manitoba. Accessed April 10, 2021.
http://hdl.handle.net/1993/30664.
MLA Handbook (7th Edition):
Slaght, Jana. “Walking cadence: A novel strategy to improve the proportion of inactive older adults who reach the Canadian Physical Activity Guidelines.” 2015. Web. 10 Apr 2021.
Vancouver:
Slaght J. Walking cadence: A novel strategy to improve the proportion of inactive older adults who reach the Canadian Physical Activity Guidelines. [Internet] [Masters thesis]. University of Manitoba; 2015. [cited 2021 Apr 10].
Available from: http://hdl.handle.net/1993/30664.
Council of Science Editors:
Slaght J. Walking cadence: A novel strategy to improve the proportion of inactive older adults who reach the Canadian Physical Activity Guidelines. [Masters Thesis]. University of Manitoba; 2015. Available from: http://hdl.handle.net/1993/30664

University of Manitoba
13.
Zubach, Lesya.
Perspectives on the use of medication in aging populations.
Degree: Disability Studies, 2010, University of Manitoba
URL: http://hdl.handle.net/1993/3905
► This exploratory study is based on two assumptions. The first assumption is that the world we live in is socially constructed. The second assumption is…
(more)
▼ This exploratory study is based on two assumptions. The first assumption is that the world we live in is socially constructed. The second assumption is that patient participation in healthcare decisions is essential. The patient, as the end-user of medications, needs to be involved in order to improve the quality of medication use.
Despite increasing attention to geriatric pharmacotherapy, there is little information available concerning the older adults’ perspectives on the use of medications. Therefore, the aim of the study was to explore the attitudes and practices regarding medication use by two groups in the aging population: aging with a disability and aging into disability. A qualitative approach, using in-depth semi-structured interviews, was used. Ten individuals aged 65 years plus, who use five or more prescription and/or over-the-counter medication, and who reside in the community answered questions about their experiences using medication.
These findings indicated that older adults’ expectations of their medications are grounded in the reality of their experiences, attitudes, beliefs and social or health care situations. The thematic framework developed from the data demonstrated that older adult’s perceptions of medication use linked to five themes through activities that helped them confirm or modify their perceptions. The five themes are: knowledge and experience, relationship with health care provider, drug management, attitude and impact of medical condition/or disability.
It is hoped that this study will provide valuable knowledge of the unique concerns of the older adults in relation to the use of medication.
Advisors/Committee Members: Blais, Christine (Disability Studies) (supervisor), Hansen, Nancy (Disability Studies) Menec, Verena (Community Health Sciences) Dean, Ruth (Nursing) (examiningcommittee).
Subjects/Keywords: Aging
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Zubach, L. (2010). Perspectives on the use of medication in aging populations. (Masters Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/3905
Chicago Manual of Style (16th Edition):
Zubach, Lesya. “Perspectives on the use of medication in aging populations.” 2010. Masters Thesis, University of Manitoba. Accessed April 10, 2021.
http://hdl.handle.net/1993/3905.
MLA Handbook (7th Edition):
Zubach, Lesya. “Perspectives on the use of medication in aging populations.” 2010. Web. 10 Apr 2021.
Vancouver:
Zubach L. Perspectives on the use of medication in aging populations. [Internet] [Masters thesis]. University of Manitoba; 2010. [cited 2021 Apr 10].
Available from: http://hdl.handle.net/1993/3905.
Council of Science Editors:
Zubach L. Perspectives on the use of medication in aging populations. [Masters Thesis]. University of Manitoba; 2010. Available from: http://hdl.handle.net/1993/3905

University of Detroit Mercy
14.
Matthew, Lelli.
Place for the Aging
.
Degree: 2019, University of Detroit Mercy
URL: http://hdl.handle.net/10429/1952
► I will be researching the demographic transformation of our era, aging population. The research will investigate how the growing elderly population will cause an increased…
(more)
▼ I will be researching the demographic transformation of our era, aging population. The research will investigate how the growing elderly population will cause an increased demand for senior living; and how to effectively design cities and communities to evolve with the changing population. Designing an appropriate solution requires an understanding of the current cultural trends, such as, a society driven culture centered around exclusion. Elderly adults are often seen as a social service need and not as a part of society that requires community planning. The housing market is driven by buyers who are healthy and have financial stability. American culture holds a lack of respect for the elderly population. Recent polls show that elderly people do have a desire to age in place; however, studies have shown that for many people, aging within an urban environment is healthier and a more ethical solution.
Subjects/Keywords: Aging
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Matthew, L. (2019). Place for the Aging
. (Thesis). University of Detroit Mercy. Retrieved from http://hdl.handle.net/10429/1952
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Matthew, Lelli. “Place for the Aging
.” 2019. Thesis, University of Detroit Mercy. Accessed April 10, 2021.
http://hdl.handle.net/10429/1952.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Matthew, Lelli. “Place for the Aging
.” 2019. Web. 10 Apr 2021.
Vancouver:
Matthew L. Place for the Aging
. [Internet] [Thesis]. University of Detroit Mercy; 2019. [cited 2021 Apr 10].
Available from: http://hdl.handle.net/10429/1952.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Matthew L. Place for the Aging
. [Thesis]. University of Detroit Mercy; 2019. Available from: http://hdl.handle.net/10429/1952
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Boston University
15.
Tyzik, Anna L.
Impact of body mass index on mortality in the veterans administration normative aging study.
Degree: MS, Epidemiology, 2020, Boston University
URL: http://hdl.handle.net/2144/41443
► High body mass index (BMI) has been found to be associated with a multitude of health issues and its longitudinal effect on mortality needs to…
(more)
▼ High body mass index (BMI) has been found to be associated with a multitude of health issues and its longitudinal effect on mortality needs to be further understood due to increasing rates of obesity. The relationship between BMI and mortality is a key public health concern due to the rise in obesity prevalence and advancing knowledge of the impact of BMI on all aspects of health.
In order to expand and further contribute to the understanding of the long-term impact of BMI on mortality, we utilized prospective, longitudinal data from the Veterans Affairs (VA) Normative Aging Study (NAS) to assess the relationship between BMI and 40-year all-cause and cause-specific mortality in men. Cox regression was used to evaluate the relationship between BMI and all-cause and cause-specific (cancer, congenital heart disease (CHD), stroke) mortality.
Of the 1,680 men included in this study, the majority were White (96.7%), born between 1920–1929, were between ages 50–59 years, married, completed some college, identified as an occasional drinker and a current smoker, and worked in a “white-collar” job. This study did not identify any men who had an underweight BMI. 594 men had normal BMI, 910 men were overweight, and 176 men were obese.
After adjusting for confounders, compared to men with normal BMI, overweight men had higher risk for CHD mortality (HR=1.33, 95% CI, 0.95–1.86), lower risk for all-cause and stroke mortality (HR=0.98, 95% CI, 0.87–1.11, HR=0.88, 95% CI, 0.53–1.45, respectively), and no difference in risk for cancer mortality (HR=1.00, 95% CI, 0.82–1.23). Obese men had higher risk for all-cause and stroke mortality (HR=1.19, 95% CI, 0.98–1.45, HR=1.26, 95% CI, 0.57–2.79, respectively) and lower risk for CHD and cancer mortality (HR=0.87, 95% CI, 0.48–1.58, HR=0.95, 95% CI, 0.68–1.33, respectively).
In conclusion, this study found that men categorized as obese had an increased risk of all-cause and stroke mortality, and men categorized as overweight had an increased risk of CHD mortality, compared to those with normal BMI. However, due to all confidence intervals crossing 1.00, there is a suggestion that BMI had an effect on mortality in this sample. These results are limited by selection bias during the NAS screening process which selected for healthy men. This may have skewed our results toward the null, potentially diminishing the association between BMI and mortality.
Advisors/Committee Members: Spiro, Avron (advisor), Aschengrau, Ann (advisor).
Subjects/Keywords: Aging
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Tyzik, A. L. (2020). Impact of body mass index on mortality in the veterans administration normative aging study. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/41443
Chicago Manual of Style (16th Edition):
Tyzik, Anna L. “Impact of body mass index on mortality in the veterans administration normative aging study.” 2020. Masters Thesis, Boston University. Accessed April 10, 2021.
http://hdl.handle.net/2144/41443.
MLA Handbook (7th Edition):
Tyzik, Anna L. “Impact of body mass index on mortality in the veterans administration normative aging study.” 2020. Web. 10 Apr 2021.
Vancouver:
Tyzik AL. Impact of body mass index on mortality in the veterans administration normative aging study. [Internet] [Masters thesis]. Boston University; 2020. [cited 2021 Apr 10].
Available from: http://hdl.handle.net/2144/41443.
Council of Science Editors:
Tyzik AL. Impact of body mass index on mortality in the veterans administration normative aging study. [Masters Thesis]. Boston University; 2020. Available from: http://hdl.handle.net/2144/41443
16.
Colledge, Alexander.
Hypertension, Infection and Inflammation and their Effects on Memory and Visuospatial Skills in Ageing.
Degree: Psychology, 2016, Umeå University
URL: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-122132
► Blood pressure has previously been associated with decline in memory over time, though the exact mechanism behind this effect is uncertain. Infections, which can…
(more)
▼ Blood pressure has previously been associated with decline in memory over time, though the exact mechanism behind this effect is uncertain. Infections, which can lead to systemic inflammation have also been linked to some cardiovascular damage to the brain, known as microbleeds, which have themselves been linked to greater declines in cognition in old age. The present study investigates whether blood pressure, a self-reported history of infection, and an indirect measure of inflammation known as the erythrocyte sedimentation rate have any association with on episodic and semantic memory and visuospatial skills in the Betula study, a Swedish longitudinal population study. The effect of elevated blood pressure (over 140 mm Hg systolic and/or 90 mm Hg diastolic), high blood sedimentation (top 33% against bottom 33% of participants), and self-reported infection were all found to not have any significant effect on episodic memory, semantic memory or visuospatial skills. Some of the possible explanations are elaborated in the discussion.
Högt blodtryck har associerats med minnesnedsättning men den exakta mekanismen hur ett samband kan förstås är dock oklar. Infektioner har visat sig ge systematiska inflammationer och har också satts i samband med vissa kardiovaskulära förändringar i hjärnan, så kallade mikroblödningar, vilka i sig har associerats med ökad risk för kognitive nedsättning i hög ålder. Denna uppsats syftar till att undersöka om blodtryck och infektion (självrapporterad infektion samt infektion indirekt mätt genom sänkereaktion) kan relateras till episodiskt och semantisk minne samt visuospatial förmåga i Betula studien, som är en svensk longitudinell populationsbaserad studie. Resultatet visade att varken högt blodtryck (över 140 mm Hg systoliskt eller 90 mm Hg diastoliskt), hög sänkereaktion (de 33 % med högst värde jämfört med de 33 % med lägst värde) eller självrapporterad infektion hade någon signifikant effekt för episodiskt minne, semantiskt minne eller visuospatial förmåga. Några möjliga förklaringar till detta resultat utvecklas i diskussionen.
The Betula Study
Subjects/Keywords: ageing; aging; blood pressure; infection; inflammation; betula
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Colledge, A. (2016). Hypertension, Infection and Inflammation and their Effects on Memory and Visuospatial Skills in Ageing. (Thesis). Umeå University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-122132
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Colledge, Alexander. “Hypertension, Infection and Inflammation and their Effects on Memory and Visuospatial Skills in Ageing.” 2016. Thesis, Umeå University. Accessed April 10, 2021.
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-122132.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Colledge, Alexander. “Hypertension, Infection and Inflammation and their Effects on Memory and Visuospatial Skills in Ageing.” 2016. Web. 10 Apr 2021.
Vancouver:
Colledge A. Hypertension, Infection and Inflammation and their Effects on Memory and Visuospatial Skills in Ageing. [Internet] [Thesis]. Umeå University; 2016. [cited 2021 Apr 10].
Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-122132.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Colledge A. Hypertension, Infection and Inflammation and their Effects on Memory and Visuospatial Skills in Ageing. [Thesis]. Umeå University; 2016. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-122132
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU
17.
Wang, Chih-Chiang.
A Study of Ageing System in Taiwan.
Degree: Master, ICAPS, 2013, NSYSU
URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0115113-115237
► The elderly population of Taiwan reached 149 million (about 7% of the total number of people in Taiwan) in 1993, the number renders that Taiwan…
(more)
▼ The elderly population of Taiwan reached 149 million (about 7% of the total number of people in Taiwan) in 1993, the number renders that Taiwan was changing into an
ageing society in the near future. Since 2000 the domestic TFR (total fertility rate) had been declining to 0.9, the number represents that Taiwan became one the lowest TFR nations of the world, and facing a severe struggle of aging and low birth rate.
Chapter on the Great Commonwealth of Peace and Prosperity mentioned that âPrivision is made of the aged till their deathâ, which means this society should be prepared for the geriatric. Now a days, more and more people choose to marry at a mature age or stay single; and further, the fertility desire of married is declining so that many people tend to not have more than one child. Hence those children would face potential issues of the age gap between parent and children. Whether the young adults have the ability to afford their parental retire life? While the others who had no children to take care of their retire life?
The purpose of this dissertation is to concentrate upon the laws and decrees, related government policies, conditions of elder care and rehabilitation, and further concerning with phenomenon and theories of aging and social welfare discussion to investigating the insufficient factors which might not fit for the current aging environment, in order to make each elder could live with respect and liberty.
Base on the reasons aforementioned, the elder care system could be reinforced by several aspects as below:
1. Concept: people should realize that idea geriatric nursing and care is relied on themselves and public support. 2. System: well coordination between related departments could provide people integrated and qualified service. 3. Pragmatic: completed geriatric care should combine with substantial appliance and software supply.
Furthermore, the growth of aging population is going to be a thriving market with potential commercial possibility, in other words, the silver economy would be regarded as a direction for the future development; moreover, in the aspect of social participation, the knowledge, experience and techniques of elders are rare and recommendable resource. The society could use those resources wisely, and let the elders to have various opportunities to contribute their ability for the public.
Advisors/Committee Members: Jia-Hsi Weng (chair), Daw-Yih Jang (committee member), Ming-Haw Wu (chair).
Subjects/Keywords: ageing; elderly welfare; aging in place; active ageing; social participation
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APA (6th Edition):
Wang, C. (2013). A Study of Ageing System in Taiwan. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0115113-115237
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Wang, Chih-Chiang. “A Study of Ageing System in Taiwan.” 2013. Thesis, NSYSU. Accessed April 10, 2021.
http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0115113-115237.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Wang, Chih-Chiang. “A Study of Ageing System in Taiwan.” 2013. Web. 10 Apr 2021.
Vancouver:
Wang C. A Study of Ageing System in Taiwan. [Internet] [Thesis]. NSYSU; 2013. [cited 2021 Apr 10].
Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0115113-115237.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Wang C. A Study of Ageing System in Taiwan. [Thesis]. NSYSU; 2013. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0115113-115237
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
18.
Eboru, Donald.
Establishing a Nursing Services Firm in South- Ostrobothnia.
Degree: 2012, Seinäjoen ammattikorkeakoulu
URL: http://www.theseus.fi/handle/10024/42930
► In Finland, along with many other parts of the European Union, the aging population has created a tremendous need for products and services devoted to…
(more)
▼ In Finland, along with many other parts of the European Union, the aging population has created a tremendous need for products and services devoted to the elderly. There will be significant growth in this, as the demographic distribution of the population will continue to shift towards greater ages in the next 10 years.
The purpose of this research was to see the potential business opportunities and establish a business in the Elderly care services, in the future.
The objectives of this thesis was to produce a feasible business plan for a nursing services firm in south Ostrobothnia, the plan is also a tool for the author personal readiness to become an entrepreneur as well as assessing the business idea and operational plan of the business.
The theoretical framework of this thesis is about population demographics of the European Union and Finland in regards to the aging population, entrepreneurship and the business plan in the perspective of starting a new business.
Advisors/Committee Members: Seinäjoen ammattikorkeakoulu.
Subjects/Keywords: ageing; population aging; demographic aging; health care; ikääntyminen; vanhustenhuolto
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Eboru, D. (2012). Establishing a Nursing Services Firm in South- Ostrobothnia. (Thesis). Seinäjoen ammattikorkeakoulu. Retrieved from http://www.theseus.fi/handle/10024/42930
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Eboru, Donald. “Establishing a Nursing Services Firm in South- Ostrobothnia.” 2012. Thesis, Seinäjoen ammattikorkeakoulu. Accessed April 10, 2021.
http://www.theseus.fi/handle/10024/42930.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Eboru, Donald. “Establishing a Nursing Services Firm in South- Ostrobothnia.” 2012. Web. 10 Apr 2021.
Vancouver:
Eboru D. Establishing a Nursing Services Firm in South- Ostrobothnia. [Internet] [Thesis]. Seinäjoen ammattikorkeakoulu; 2012. [cited 2021 Apr 10].
Available from: http://www.theseus.fi/handle/10024/42930.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Eboru D. Establishing a Nursing Services Firm in South- Ostrobothnia. [Thesis]. Seinäjoen ammattikorkeakoulu; 2012. Available from: http://www.theseus.fi/handle/10024/42930
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Edinburgh
19.
Pickersgill, Mhairi.
An investigation into the effects of healthy adult ageing on everyday multitasking and the cognitive correlates that contribute to enhanced performance.
Degree: 2013, University of Edinburgh
URL: http://hdl.handle.net/1842/8572
► Multitasking is an extremely important skill and one that is ubiquitous to success in everyday life. Patients with frontal lobe damage have shown impairments in…
(more)
▼ Multitasking is an extremely important skill and one that is ubiquitous to success in everyday life. Patients with frontal lobe damage have shown impairments in their ability to multitask, despite performing normally on traditional neuropsychological tests of executive function. The frontal lobes are associated with natural age-related decline which, as a result, may cause impairment in the multitasking ability of older adults. This study investigates the effects of healthy adult
ageing on multitasking by comparing the age-related performance of older adults (aged 60-80) with younger adults (aged 18-40). The supportive cognitive constructs underlying enhanced multitasking performance and the age-related trajectory of these constructs in terms of their relative influence are also investigated in this study. Participants were tested on a measure of multitasking involving 4 subtasks which were to be attempted within a 10 minute period, with the overall aim being to score as many points as possible across all 4 tasks; 20 young adults and 20 old adults were tested. Results showed a significant difference (p<0.05) in multitasking performance between young and old age groups, with older adults performing significantly poorer than young. Retrospective and prospective memory significantly correlated with multitasking performance in both young and old age groups, but elicited stronger correlations and explained a larger proportion of the variance in younger adults performance than old. In healthy adult
ageing this decline in the supportive cognitive constructs of retrospective and prospective memory meant an increased dependency on factors such as intelligence and general cognitive ability in order to successfully multitask. These age-related changes in the cognitive correlates supporting multitasking performance and the emerging importance of intelligence and cognitive ability to the sustainability of performance in old age has important implications for future research regarding multitasking and
ageing.
Advisors/Committee Members: MacPherson, Sarah.
Subjects/Keywords: multitasking; ageing
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Pickersgill, M. (2013). An investigation into the effects of healthy adult ageing on everyday multitasking and the cognitive correlates that contribute to enhanced performance. (Thesis). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/8572
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Pickersgill, Mhairi. “An investigation into the effects of healthy adult ageing on everyday multitasking and the cognitive correlates that contribute to enhanced performance.” 2013. Thesis, University of Edinburgh. Accessed April 10, 2021.
http://hdl.handle.net/1842/8572.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Pickersgill, Mhairi. “An investigation into the effects of healthy adult ageing on everyday multitasking and the cognitive correlates that contribute to enhanced performance.” 2013. Web. 10 Apr 2021.
Vancouver:
Pickersgill M. An investigation into the effects of healthy adult ageing on everyday multitasking and the cognitive correlates that contribute to enhanced performance. [Internet] [Thesis]. University of Edinburgh; 2013. [cited 2021 Apr 10].
Available from: http://hdl.handle.net/1842/8572.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Pickersgill M. An investigation into the effects of healthy adult ageing on everyday multitasking and the cognitive correlates that contribute to enhanced performance. [Thesis]. University of Edinburgh; 2013. Available from: http://hdl.handle.net/1842/8572
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
20.
ORR, JOANNA.
Ageing outcomes in women and men in Ireland: the role of the religious social context.
Degree: School of Medicine. CentreFor Medical Gerontology, 2020, Trinity College Dublin
URL: http://hdl.handle.net/2262/93002
► Aim & background: The aim of this thesis is to explore how the religious social context in Ireland has helped shape the health and ageing…
(more)
▼ Aim & background: The aim of this thesis is to explore how the religious social context in Ireland has helped shape the health and
ageing outcomes of older women and men. Understanding the factors behind the ability to maintain physical, cognitive and psychosocial wellbeing is crucial in the context of rapidly aging populations. Research recognises differences in health trajectories for men and women, but there is a lack of understanding of the mechanisms behind the role of gender in
ageing. Within the Irish context, the impact of social and individual religiosity on women's social roles and
ageing outcomes are particularly important. The effects of religiosity on health have been widely studied, but little consensus exists on the pathways that link religiosity and
ageing. Methods: Four studies were conducted using nationally representative data from The Irish Longitudinal Study on
Ageing (TILDA). Data was analysed using multilevel modelling techniques to longitudinally test causal relationships between religious belief and practice, parity and
ageing outcomes in older Irish men and women. A fifth study combined quantitative data from TILDA with qualitative data from Irish women aged 65 and over. Qualitative data was collected to complement and further illuminate results from the quantitative phase in a mixed methods analysis of wellbeing in later life. Results: Findings of both quantitative and qualitative data showed that religion and the religious social context are associated with health in late life through complex pathways. Religious attendance in those who are religious was found to be the factor most strongly associated with health. More frequent religious attendance was associated with lower mortality risk, lower depressive symptoms and higher wellbeing. Results for a link between religious attendance and physical function and cognition were inconclusive. Qualitative data suggested the positive associations of religious attendance may be explained by social connectedness and psychological benefits. However, qualitative data also illustrated possible negative effects of religiosity in Ireland. Conclusion: Religious involvement in those who are religious is likely to be related to health outcomes through social connectedness and other factors which support physical and mental health in Ireland.
Advisors/Committee Members: McGarrigle, Christine.
Subjects/Keywords: Ageing; Religion
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
ORR, J. (2020). Ageing outcomes in women and men in Ireland: the role of the religious social context. (Thesis). Trinity College Dublin. Retrieved from http://hdl.handle.net/2262/93002
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
ORR, JOANNA. “Ageing outcomes in women and men in Ireland: the role of the religious social context.” 2020. Thesis, Trinity College Dublin. Accessed April 10, 2021.
http://hdl.handle.net/2262/93002.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
ORR, JOANNA. “Ageing outcomes in women and men in Ireland: the role of the religious social context.” 2020. Web. 10 Apr 2021.
Vancouver:
ORR J. Ageing outcomes in women and men in Ireland: the role of the religious social context. [Internet] [Thesis]. Trinity College Dublin; 2020. [cited 2021 Apr 10].
Available from: http://hdl.handle.net/2262/93002.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
ORR J. Ageing outcomes in women and men in Ireland: the role of the religious social context. [Thesis]. Trinity College Dublin; 2020. Available from: http://hdl.handle.net/2262/93002
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of KwaZulu-Natal
21.
Naiker, Jacqueline.
The association between physical activity and body mass index, quality of life, life-space mobility and successful aging in older adults.
Degree: 2018, University of KwaZulu-Natal
URL: https://researchspace.ukzn.ac.za/handle/10413/18359
► The biggest threat to healthy aging is sedentary living with the golden years of most individuals being affected by disorders that are exacerbated by unhealthy…
(more)
▼ The biggest threat to healthy aging is sedentary living with the golden years of most individuals being affected by disorders that are exacerbated by unhealthy lifestyles. Helping people age better is important and it can be achieved through participation in regular physical activity. Monitoring population levels of physical activity using subjective and objective measures is an important part of a public health response. This study aimed to determine the physical activity and body composition levels of older adults and the association of physical activity on body composition with health-related quality of life, life-space mobility and successful aging of life of older adults in Chatsworth, KwaZulu-Natal Province. A total of 210 older adults were randomly selected, both male and females, participated in the study and completed the Global Physical Activity Questionnaire, RAND Medical Outcomes Study 36-Item Health Survey, Life-Space Mobility Questionnaire and the Successful Aging Scale. BMI (kg/m2) was determined and step count was tracked for 7 days with the Omoron Pedometer. There were positive correlations between the participants actual physical activity and self-reported physical activity levels (r=0.183, p=0.008). The majority of the participants were overweight (51%, n=107). There was no significant relationship between BMI (r=0.63, p=0.366) and actual steps taken as well as no significant correlation with SF-36 and the average number of steps in 7 days of the participants (r=-0.112, p=0.107). A significant correlation between total LSQ (r=0.224, p=0.001) and SAS (r=-0.152, p=0.027) with the average number of steps in 7 days of the participant was noted. It was concluded that there is a positive relationship between self-reported physical activity and actual activity and life-space mobility and successful aging of life in older adults, but such relationship is not meaningfully predictive in this population. Strategies to improve physical inactivity in the elderly need to be implemented to ensure successful aging and quality of life in the elderly.
Advisors/Committee Members: Grace, Jeanne Martin. (advisor).
Subjects/Keywords: Physical activity.; Body mass index.; Life-space mobility.; Older Adults.; Healthy ageing.; Ageing.; Aging.
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Naiker, J. (2018). The association between physical activity and body mass index, quality of life, life-space mobility and successful aging in older adults. (Thesis). University of KwaZulu-Natal. Retrieved from https://researchspace.ukzn.ac.za/handle/10413/18359
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Naiker, Jacqueline. “The association between physical activity and body mass index, quality of life, life-space mobility and successful aging in older adults.” 2018. Thesis, University of KwaZulu-Natal. Accessed April 10, 2021.
https://researchspace.ukzn.ac.za/handle/10413/18359.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Naiker, Jacqueline. “The association between physical activity and body mass index, quality of life, life-space mobility and successful aging in older adults.” 2018. Web. 10 Apr 2021.
Vancouver:
Naiker J. The association between physical activity and body mass index, quality of life, life-space mobility and successful aging in older adults. [Internet] [Thesis]. University of KwaZulu-Natal; 2018. [cited 2021 Apr 10].
Available from: https://researchspace.ukzn.ac.za/handle/10413/18359.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Naiker J. The association between physical activity and body mass index, quality of life, life-space mobility and successful aging in older adults. [Thesis]. University of KwaZulu-Natal; 2018. Available from: https://researchspace.ukzn.ac.za/handle/10413/18359
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
22.
Martineau, Aurélien.
Les immigrés au seuil du grand âge : analyse des parcours de vieillissement et de fin de vie dans les territoires de vie des migrants : The immigrant nearing old age.
Degree: Docteur es, Géographie, 2018, Angers
URL: http://www.theses.fr/2018ANGE0052
► Vieillir immigré est devenu une situation commune à un nombre grandissant de personnes en France. En 2015, près d’1,5 million de personnes immigrées étaient âgées…
(more)
▼ Vieillir immigré est devenu une situation commune à un nombre grandissant de personnes en France. En 2015, près d’1,5 million de personnes immigrées étaient âgées de 60 ans et plus. La constante augmentation du nombre d’immigrés âgés constitue une question sociale et politique en France, ce qui a été confirmé tant par les récents travaux de l’Assemblée nationale que par l’avancée des connaissances scientifiques. Le nombre de travaux produits sur des territoires différents, là où les migrants âgés sont plus ou moins présents démographiquement reste encore aujourd’hui restreint. Face à ce constat, l’objectif de cette thèse par articles est de proposer une lecture territoriale et gérontologique de la vieillesse en migration. Deux terrains d’étude ont été retenus dans le cadre du projet doctoral (premièrement, les villes d’Angers et de Cholet en Maine-et-Loire et deuxièmement, la Ville de Montreuil en Seine-Saint-Denis). Les terrains de recherche ont été l’occasion d’analyser les conditions de vieillissement des personnes immigrées dans des contextes spatiaux différents (analyse des données territoriales et du discours des acteurs médico-sociaux, associatifs et politiques intervenants auprès des immigrés vieillissants). Dans la continuité, une analyse des récits biographiques d’un échantillon de migrants âgés résidant en Maine-et-Loire a été effectuée pou mettre en exergue les enjeux sociaux et spatiaux structurant les expériences de vieillissement des immigrés. Les résultats de recherche produits témoignent de la nécessité d’appréhender l’hétérogénéité de ces publics et d’étudier leurs besoins en regard de leurs parcours et des espaces qui structurent leur (fin de) vie.
In France, getting old as an immigrant became a condition shared by a growing number of people. In 2015, about 1.5million of immigrants are 60years old or more. In France, the constant increase in the number of elderly immigrants represents a social and political issue, a fact confirmed by the recent works of the national assembly as well as by the development of scientific research. Nonetheless, the diversity of studies dealing with different territories inhabited by elderly immigrants remains limited. Consequently, this thesis (structured around several scientific articles) aims at proposing a representation of the “migrating elderly”, articulating a territorial and gerontological approach. Two different territories were taken into consideration: Angers andCholet (Maine-et-Loire), and Montreuil (Seine-Saint-Denis).This selection provided the opportunity to analyse the aging conditions of migrating population which evolve according to different spatial contexts. In this study, we considered territorial data, medico-social accounts, as well as the work of associations and political interventions to elderly immigrants.In addition, biographical facts and stories from as ample of elderly migrants in Maine-et-Loire were analysed to highlight the political and social issues that structure the aging conditions of immigrants.The result of this work proves…
Advisors/Committee Members: Fleuret, Sébastien (thesis director), Plard, Mathilde (thesis director).
Subjects/Keywords: Vieillissement; Migration; Territoire de vie; Successful Ageing; Aging; Migration; Territories; Successful Ageing; 910
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Martineau, A. (2018). Les immigrés au seuil du grand âge : analyse des parcours de vieillissement et de fin de vie dans les territoires de vie des migrants : The immigrant nearing old age. (Doctoral Dissertation). Angers. Retrieved from http://www.theses.fr/2018ANGE0052
Chicago Manual of Style (16th Edition):
Martineau, Aurélien. “Les immigrés au seuil du grand âge : analyse des parcours de vieillissement et de fin de vie dans les territoires de vie des migrants : The immigrant nearing old age.” 2018. Doctoral Dissertation, Angers. Accessed April 10, 2021.
http://www.theses.fr/2018ANGE0052.
MLA Handbook (7th Edition):
Martineau, Aurélien. “Les immigrés au seuil du grand âge : analyse des parcours de vieillissement et de fin de vie dans les territoires de vie des migrants : The immigrant nearing old age.” 2018. Web. 10 Apr 2021.
Vancouver:
Martineau A. Les immigrés au seuil du grand âge : analyse des parcours de vieillissement et de fin de vie dans les territoires de vie des migrants : The immigrant nearing old age. [Internet] [Doctoral dissertation]. Angers; 2018. [cited 2021 Apr 10].
Available from: http://www.theses.fr/2018ANGE0052.
Council of Science Editors:
Martineau A. Les immigrés au seuil du grand âge : analyse des parcours de vieillissement et de fin de vie dans les territoires de vie des migrants : The immigrant nearing old age. [Doctoral Dissertation]. Angers; 2018. Available from: http://www.theses.fr/2018ANGE0052

University of Manchester
23.
Smart, Emily Louise.
Ageing well with psychosis.
Degree: 2018, University of Manchester
URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:315466
► There are approximately 70,000 adults (aged <50) in England living with a diagnosis of schizophrenia or psychosis related disorder. With an increase in life expectancy,…
(more)
▼ There are approximately 70,000 adults (aged <50)
in England living with a diagnosis of schizophrenia or psychosis
related disorder. With an increase in life expectancy, and an
ageing population this figure is likely to double in the next
decade (Vahia & Cohen, 2008). The needs of older adults change
across the lifecourse for example with health co-morbidities and
neurocognitive decline. As such older adults with psychosis
represent a large burden to the NHS. It is therefore imperative to
understand what it means for this population to ‘age well’ and
what interventions are available to help to further support
wellbeing in older age. Paper 1 presents a systematic review of
studies examining the effectiveness of psychosocial interventions
for older adults with psychosis at improving social functioning. A
literature search was conducted using the following electronic
databases: Web of Science, PsycINFO, Embase, CINAHL and Medline.
Seventeen studies were identified that satisfied inclusion criteria
for the review. The review found evidence for the use of skills
training interventions, both with respect to social skills and
psychiatric and physical health skills training. There was not
enough evidence to recommend any other psychosocial interventions.
Overall, the review revealed a need for more robust research about
interventions that have been shown to be effective in other age
groups. Paper 2 presents a qualitative study exploring what the
concept of ‘
ageing well’ means to mid to older aged adults with
psychosis. Sixteen participants, aged 50-74 (Mage = 61), diagnosed
with psychosis related disorders (i.e. schizophrenia,
schizoaffective disorder etc.), were interviewed about their views
about
ageing well, and how this can be best supported. Recordings
were transcribed verbatim and then analysed using thematic
analysis. Four themes were identified from the data: i) engaging
with life, ii) attitude to life and
ageing, iii) maintaining
wellbeing and iv) having good relationships. This study showed that
people with psychosis can consider themselves to be
ageing well.
Unlike previous literature participants also reported the
importance of their relationships with professionals, developing a
mastery over their mental health difficulties and the continued
impact of stigma on
ageing well. Therapeutic approaches that target
these domains may therefore facilitate
ageing well with this
population. Paper 3 is a critical reflection of the systematic
review, the empirical paper and the research process as a whole. It
aims to provide justification for, and explanations of key
decisions that were made and outline clinical and future research
implications
Advisors/Committee Members: BROWN, LAURA LJE, Berry, Katherine, Palmier-Claus, Jasper, Brown, Laura.
Subjects/Keywords: Psychosis; Ageing; Psychosocial interventions; Successful ageing
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Smart, E. L. (2018). Ageing well with psychosis. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:315466
Chicago Manual of Style (16th Edition):
Smart, Emily Louise. “Ageing well with psychosis.” 2018. Doctoral Dissertation, University of Manchester. Accessed April 10, 2021.
http://www.manchester.ac.uk/escholar/uk-ac-man-scw:315466.
MLA Handbook (7th Edition):
Smart, Emily Louise. “Ageing well with psychosis.” 2018. Web. 10 Apr 2021.
Vancouver:
Smart EL. Ageing well with psychosis. [Internet] [Doctoral dissertation]. University of Manchester; 2018. [cited 2021 Apr 10].
Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:315466.
Council of Science Editors:
Smart EL. Ageing well with psychosis. [Doctoral Dissertation]. University of Manchester; 2018. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:315466

University of Melbourne
24.
Gregorevic, Katherine Jennifer.
Health assets and deficits in hospitalised older adults.
Degree: 2019, University of Melbourne
URL: http://hdl.handle.net/11343/230668
► Frailty is a loss of physiological reserve that leaves individuals at risk of poor recovery when exposed to a stressor. Frailty has been identified as…
(more)
▼ Frailty is a loss of physiological reserve that leaves individuals at risk of poor recovery when exposed to a stressor. Frailty has been identified as a risk factor for poor outcomes for older adults when they are admitted to hospital, although there are still some barriers to implementation of measurement tools. Some frail older adults will still make a good recovery. Health assets are factors that are associated with health and recovery and are also desirable in their own right. Inclusion of health assets in models of illness and recovery may improve prognostication and identify patient centred strategies to facilitate recovery.
Aims of the PhD
1. Determine whether is feasible to measure frailty based on routine clinical assessment
2. Examine whether health assets can be identified in hospitalised older adults
3. Investigate whether individual health assets improve outcomes for hospitalised older adults
4. Develop a health assets index
5. Validate the health assets index in hospitalised older adults
Methods
In addressing these aims, five phases of research were undertaken:
Phase 1: A systematic review of the literature was undertaken to identify health assets in the hospital setting. MEDLINE, EMBASE, CINAHL and PsycINFO were searched to identify studies examining outcomes for hospitalised older adults. Included studies examined at least one potential individual health asset, which was a psychosocial characteristic or health characteristic. Study quality was assessed, and findings are narratively described.
Phase 2: A prospective cohort study was conducted in an acute general medical unit to determine whether frailty could be measured based on routine clinical information by junior medical staff. All patients aged 65 and over admitted to a general medical unit during August and September 2013 were eligible for the study. CFS score at baseline was documented by a member of the treating medical team. Demographic information and outcomes were obtained from medical records. The primary outcomes were functional decline and death within three months.
Phase 3: A secondary analysis of an existing data set was conducted to examine the interaction between health assets and frailty. Patients of 1418 aged ≥ 70 years admitted to 11 hospitals in Australia were evaluated at admission using the interRAI assessment system for Acute Care, which surveys a large number of domains, including cognition, communication, mood and behaviour, activities of daily living, continence, nutrition, skin condition, falls and medical diagnosis. The data set was interrogated for potential health assets and a multiple logistic regression adjusted for frailty index, age and gender as covariates was performed for the outcomes mortality, length of stay, readmission and new need for residential care.
Phase 4: Based on phases 2 and 3, a heath assets index was created. A pilot study was conducted to determine the feasibility of collecting this information in hospitalised older adults.
Phase 5: A prospective cohort study was…
Subjects/Keywords: frailty; health assets; ageing; healthy ageing; hospitalisation
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APA (6th Edition):
Gregorevic, K. J. (2019). Health assets and deficits in hospitalised older adults. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/230668
Chicago Manual of Style (16th Edition):
Gregorevic, Katherine Jennifer. “Health assets and deficits in hospitalised older adults.” 2019. Doctoral Dissertation, University of Melbourne. Accessed April 10, 2021.
http://hdl.handle.net/11343/230668.
MLA Handbook (7th Edition):
Gregorevic, Katherine Jennifer. “Health assets and deficits in hospitalised older adults.” 2019. Web. 10 Apr 2021.
Vancouver:
Gregorevic KJ. Health assets and deficits in hospitalised older adults. [Internet] [Doctoral dissertation]. University of Melbourne; 2019. [cited 2021 Apr 10].
Available from: http://hdl.handle.net/11343/230668.
Council of Science Editors:
Gregorevic KJ. Health assets and deficits in hospitalised older adults. [Doctoral Dissertation]. University of Melbourne; 2019. Available from: http://hdl.handle.net/11343/230668

University of Manchester
25.
Smart, Emily L.
Ageing well with psychosis.
Degree: Thesis (D.Clin.Psy.), 2018, University of Manchester
URL: https://www.research.manchester.ac.uk/portal/en/theses/ageing-well-with-psychosis(132a51bb-7b03-44fd-955e-bdcbce2a7805).html
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.816263
► There are approximately 70,000 adults (aged ≥ 50) in England living with a diagnosis of schizophrenia or psychosis related disorder. With an increase in life…
(more)
▼ There are approximately 70,000 adults (aged ≥ 50) in England living with a diagnosis of schizophrenia or psychosis related disorder. With an increase in life expectancy, and an ageing population this figure is likely to double in the next decade (Vahia & Cohen, 2008). The needs of older adults change across the lifecourse for example with health comorbidities and neurocognitive decline. As such older adults with psychosis represent a large burden to the NHS. It is therefore imperative to understand what it means for this population to 'age well' and what interventions are available to help to further support wellbeing in older age. Paper 1 presents a systematic review of studies examining the effectiveness of psychosocial interventions for older adults with psychosis at improving social functioning. A literature search was conducted using the following electronic databases: Web of Science, PsycINFO, Embase, CINAHL and Medline. Seventeen studies were identified that satisfied inclusion criteria for the review. The review found evidence for the use of skills training interventions, both with respect to social skills and psychiatric and physical health skills training. There was not enough evidence to recommend any other psychosocial interventions. Overall, the review revealed a need for more robust research about interventions that have been shown to be effective in other age groups. Paper 2 presents a qualitative study exploring what the concept of 'ageing well' means to mid to older aged adults with psychosis. Sixteen participants, aged 50-74 (Mage = 61), diagnosed with psychosis related disorders (i.e. schizophrenia, schizoaffective disorder etc.), were interviewed about their views about ageing well, and how this can be best supported. Recordings were transcribed verbatim and then analysed using thematic analysis. Four themes were identified from the data: i) engaging with life, ii) attitude to life and ageing, iii) maintaining wellbeing and iv) having good relationships. This study showed that people with psychosis can consider themselves to be ageing well. Unlike previous literature participants also reported the importance of their relationships with professionals, developing a mastery over their mental health difficulties and the continued impact of stigma on ageing well. Therapeutic approaches that target these domains may therefore facilitate ageing well with this population. Paper 3 is a critical reflection of the systematic review, the empirical paper and the research process as a whole. It aims to provide justification for, and explanations of key decisions that were made and outline clinical and future research implications.
Subjects/Keywords: Psychosis; Ageing; Psychosocial interventions; Successful ageing
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Smart, E. L. (2018). Ageing well with psychosis. (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/ageing-well-with-psychosis(132a51bb-7b03-44fd-955e-bdcbce2a7805).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.816263
Chicago Manual of Style (16th Edition):
Smart, Emily L. “Ageing well with psychosis.” 2018. Doctoral Dissertation, University of Manchester. Accessed April 10, 2021.
https://www.research.manchester.ac.uk/portal/en/theses/ageing-well-with-psychosis(132a51bb-7b03-44fd-955e-bdcbce2a7805).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.816263.
MLA Handbook (7th Edition):
Smart, Emily L. “Ageing well with psychosis.” 2018. Web. 10 Apr 2021.
Vancouver:
Smart EL. Ageing well with psychosis. [Internet] [Doctoral dissertation]. University of Manchester; 2018. [cited 2021 Apr 10].
Available from: https://www.research.manchester.ac.uk/portal/en/theses/ageing-well-with-psychosis(132a51bb-7b03-44fd-955e-bdcbce2a7805).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.816263.
Council of Science Editors:
Smart EL. Ageing well with psychosis. [Doctoral Dissertation]. University of Manchester; 2018. Available from: https://www.research.manchester.ac.uk/portal/en/theses/ageing-well-with-psychosis(132a51bb-7b03-44fd-955e-bdcbce2a7805).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.816263

University of Edinburgh
26.
Campbell, AJ.
The effect of ageing on dual tasking performance: A tale of two paradigms.
Degree: 2010, University of Edinburgh
URL: http://hdl.handle.net/1842/5001
► Dual tasking is the ability to perform two tasks simultaneously. There is some debate in literature as to whether or not ageing has a specific…
(more)
▼ Dual tasking is the ability to perform two tasks simultaneously. There is some debate in literature as to whether or not
ageing has a specific effect on dual tasking ability. Our study investigated this area further by assessing the performance of a younger group of 25 adults aged 19-23 years and an older group of 25 healthy adults 65-88 in two slightly differing dual task paradigms. In both paradigms the participants were required to perform a tapping task combined with a digit recall task. Difficulty in the first paradigm was adjusted by increasing the tapping speed required. In the second paradigm, difficulty of the tapping task was adjusted by increasing the level of accuracy required. Task difficulty was titrated for each individual and single task scores were controlled for when assessing dual task performance. An array of Neuropsychological tests were also carried out to test memory and executive functioning. The younger group performed significantly better than the older group in the dual task paradigm adjusted for speed but there was no significant difference between the groups in the paradigm adjusted for accuracy. This suggested that dual tasking ability was not impaired by
ageing and that the difference in performance in the paradigm adjusted for speed was due to an exaggeration of the slower processing speed in older adults. The older group was found to perform significantly worse than the younger group in almost all the measures of memory and executive functioning.
Advisors/Committee Members: Foley, J.
Subjects/Keywords: dual tasking; ageing
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Campbell, A. (2010). The effect of ageing on dual tasking performance: A tale of two paradigms. (Thesis). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/5001
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Campbell, AJ. “The effect of ageing on dual tasking performance: A tale of two paradigms.” 2010. Thesis, University of Edinburgh. Accessed April 10, 2021.
http://hdl.handle.net/1842/5001.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Campbell, AJ. “The effect of ageing on dual tasking performance: A tale of two paradigms.” 2010. Web. 10 Apr 2021.
Vancouver:
Campbell A. The effect of ageing on dual tasking performance: A tale of two paradigms. [Internet] [Thesis]. University of Edinburgh; 2010. [cited 2021 Apr 10].
Available from: http://hdl.handle.net/1842/5001.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Campbell A. The effect of ageing on dual tasking performance: A tale of two paradigms. [Thesis]. University of Edinburgh; 2010. Available from: http://hdl.handle.net/1842/5001
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Edinburgh
27.
Sedcole, Rebecca.
Age differences in conceptual and perceptual comparisons of visual stimuli.
Degree: 2013, University of Edinburgh
URL: http://hdl.handle.net/1842/8710
► Investigations of age-related increases in false recognition have highlighted the tendencies of older adults to designate new conceptually similar visual stimuli as having been seen…
(more)
▼ Investigations of age-related increases in false recognition have highlighted the tendencies of older adults to designate new conceptually similar visual stimuli as having been seen before. Studies have shown that older adults place different levels of attention on the conceptual and perceptual details of stimuli and these findings are the basis for most encoding theories of false recognition. It is not known whether there are age discrepancies in how similar items are perceived to be and whether older adults are able to attend to the distinguishing features in visual stimuli. The present study aimed to determine whether any age-differences existed between conceptual and perceptual similarity judgements. Two groups of older and younger adults rated the similarity of pairs of visual stimuli in either the conceptual or perceptual dimensions. Older adults rated the items as being more conceptually similar than the younger adults but there was no age difference between similarity judgements in the perceptual dimension. This inability to distinguish between categorically similar items lead to poor pattern separation at encoding and a subsequent shift to pattern completion at retrieval, resulting in increased rates of false recognition. Older adults are equally able to determine the distinctive perceptual features as younger adults, but they may not be able to attend to these details spontaneously. Future studies might determine whether attention has an effect on age differences in similarity judgements. These results will also be used in an fMRI study examining the encoding-related brain activations leading to verbatim and gist-based memory.
Advisors/Committee Members: Morcom, Alexa.
Subjects/Keywords: ageing; false memory
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Sedcole, R. (2013). Age differences in conceptual and perceptual comparisons of visual stimuli. (Thesis). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/8710
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Sedcole, Rebecca. “Age differences in conceptual and perceptual comparisons of visual stimuli.” 2013. Thesis, University of Edinburgh. Accessed April 10, 2021.
http://hdl.handle.net/1842/8710.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Sedcole, Rebecca. “Age differences in conceptual and perceptual comparisons of visual stimuli.” 2013. Web. 10 Apr 2021.
Vancouver:
Sedcole R. Age differences in conceptual and perceptual comparisons of visual stimuli. [Internet] [Thesis]. University of Edinburgh; 2013. [cited 2021 Apr 10].
Available from: http://hdl.handle.net/1842/8710.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Sedcole R. Age differences in conceptual and perceptual comparisons of visual stimuli. [Thesis]. University of Edinburgh; 2013. Available from: http://hdl.handle.net/1842/8710
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Manchester
28.
Ravindrarajah, Rathi.
Frailty and Obesity in Ageing Men.
Degree: 2015, University of Manchester
URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:263387
► Background & Aim: Frailty is a syndrome characterised by multisystem physiological dysfunction, making older adults vulnerable to stressors. Frailty is often considered as a wasting…
(more)
▼ Background & Aim: Frailty is a syndrome
characterised by multisystem physiological dysfunction, making
older adults vulnerable to stressors. Frailty is often considered
as a wasting disorder however there is increasing evidence that
many overweight and obese people are also frail. The broad aim of
the thesis was to explore whether anthropometric indicators of
adiposity and obesity are linked with an increased susceptibility
to frailty in middle aged and older European men.Methods: 3,369 men
aged 40-79 years were recruited from population registers in eight
European centres for participation in the European Male
Ageing
Study (EMAS) a prospective study of male
ageing. Subjects were
invited by letter to attend for an interviewer-assisted
questionnaire, functional assessments and anthropometric
measurements including height (m), weight (Kg), waist (cm) and hip
circumference (cm), from which body mass index (BMI) (Kg/m2), and
waist hip ratio (WHR) were calculated. Subjects were assessed again
after a median of 4.5 years, using the same study instruments. They
were asked also about occurrence of falls in the past year. Frailty
was assessed using adaptations (because of availability of data) of
two established methods, the frailty phenotype (FP) and the Frail
Scale (FS), both comprising 5 domains, and also a Frailty Index
(FI) a ratio based on observed over a range of potential deficits.
Incident frailty was defined as the new occurrence of frailty in
those who were not frail at baseline.Results: 3369 men, mean age
60yrs contributed data to this analysis. Using data from the study
the prevalence of frailty at baseline was 2.6% using the FP method
and 2.7% using the FS and the mean Frailty Index was 0.13
(IQR=0.05-0.18). The prevalence of frailty increased with age.
Those who were frail, using either definition had a significantly
increased waist circumference (WC) and also WHR. The FI was higher
and also correlated with these anthropometric measures. During
follow-up there were 193 deaths. Compared to those who were not
frail at baseline those who were frail had an increased risk of
mortality and also were more likely to experience falls. Of those
who were not frail at baseline and who completed the follow-up
assessments the incidence of frailty ranged from 2.1% to 3.5%
depending on the definition. Mean Frailty Index increased from 0.12
to 0.13, in men who returned at follow-up. An increase in baseline
adiposity measures WC & WHR was significantly associated with
frailty incidence, at follow-up using both (FP & FS) models,
while there was no association with BMI and % body fat. An increase
in all baseline adiposity measure was significantly associated with
frailty incidence defined by the FI and also a change in the
Frailty Index. Conclusion: Frailty models adapted to EMAS predicted
adverse outcomes. Obesity was associated with frailty and predicted
frailty incidence at follow-up. Interventions to combat obesity in
the elderly may help in preventing and reducing the occurrence of
frailty.
Advisors/Committee Members: WU, FREDERICK FCW, PENDLETON, NEIL N, LEE, DAVID DM, Wu, Frederick, Pendleton, Neil, Lee, David, O'Neill, Terence.
Subjects/Keywords: Frailty; Obesity; Ageing
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Ravindrarajah, R. (2015). Frailty and Obesity in Ageing Men. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:263387
Chicago Manual of Style (16th Edition):
Ravindrarajah, Rathi. “Frailty and Obesity in Ageing Men.” 2015. Doctoral Dissertation, University of Manchester. Accessed April 10, 2021.
http://www.manchester.ac.uk/escholar/uk-ac-man-scw:263387.
MLA Handbook (7th Edition):
Ravindrarajah, Rathi. “Frailty and Obesity in Ageing Men.” 2015. Web. 10 Apr 2021.
Vancouver:
Ravindrarajah R. Frailty and Obesity in Ageing Men. [Internet] [Doctoral dissertation]. University of Manchester; 2015. [cited 2021 Apr 10].
Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:263387.
Council of Science Editors:
Ravindrarajah R. Frailty and Obesity in Ageing Men. [Doctoral Dissertation]. University of Manchester; 2015. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:263387

University of Manchester
29.
Mares, Alina.
Study of the endoplasmic reticulum proteostasis network
during ageing.
Degree: 2013, University of Manchester
URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:189372
► The functional integrity of the proteome is essential for proper cell functioning. Protein homeostasis, or proteostasis, is maintained by a network of pathways that mediate…
(more)
▼ The functional integrity of the proteome is
essential for proper cell functioning. Protein homeostasis, or
proteostasis, is maintained by a network of pathways that mediate
the biosynthesis, folding and degradation of proteins. Accumulating
evidence suggest that
ageing is associated with a general decline
in protein homeostasis. Proteins are synthesised in the cytosol as
extended polypeptide chains, which must then be folded in to their
native conformation, before moving to their site of function.
Protein folding occurs in different subcellular compartments, such
as the cytosol and the endoplasmic reticulum (ER). Due to the
nature of the proteins that are processed in the ER (e.g. ionic
channels, receptors, hormones, signalling molecules), the function
of this compartment can be seen to be of vital importance to the
cells. However, the effect of age on ER protein homeostasis is
virtually unknown. A combination of post-mortem mouse tissues and
cell-based models were used to examine the impact of age on ER
protein folding, quality control and the ER stress response.
Analysis of the expression level of ER-resident and ER-linked
proteins showed a number of age-related changes in mouse tissues,
in human fibroblasts aged in vitro by serial passage, and human
fibroblasts obtained from young and old donors (in vivo aged
cells). Overall, the pattern of changes was variable between
different tissues and cell systems. However, a common feature of
aged tissues and both cellular models of
ageing, was a significant
increase in phosphorylation of eIF2α, indicating that ER protein
homeostasis is affected with age. In addition,
ageing in several
tissues and in both cellular systems was associated with
accumulation of polyubiquitinated substrates, suggesting that
degradation of abnormal proteins via the proteasome is deficient.
More detailed investigation of ER proteostasis using the cellular
models showed that in vitro aged cells had a decreased capacity to
fold a temperature sensitive model membrane protein (ts O45 VGV-G)
and were less efficient at degrading two model substrates of the
ER-associated degradation pathway. Since the ER protein folding and
degradation pathways are modulated by ER stress response signalling
to restore ER homeostasis, therefore their malfunctioning would
impact on the ability of aged cells to cope with stress. Indeed, in
the aged cells both PERK and IRE-1 signalling were perturbed. In
addition, the level of BiP was not upregulated following ER stress
in the aged cells. Moreover, ER stress induction led to decreased
cell survival in the case of aged cells, showing that the inability
of aged cells to maintain ER protein homeostasis results in
increased susceptibility to cell death. All these data together
shows how perturbed ER proteostasis can occur with increased age
and its impact on overall cell wellbeing, therefore provide new
insight into mechanisms of cell
ageing.
Advisors/Committee Members: BOOT-HANDFORD, RAYMOND RP, Boot-Handford, Raymond, Swanton, Lisa.
Subjects/Keywords: ageing; ER proteostsis
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Mares, A. (2013). Study of the endoplasmic reticulum proteostasis network
during ageing. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:189372
Chicago Manual of Style (16th Edition):
Mares, Alina. “Study of the endoplasmic reticulum proteostasis network
during ageing.” 2013. Doctoral Dissertation, University of Manchester. Accessed April 10, 2021.
http://www.manchester.ac.uk/escholar/uk-ac-man-scw:189372.
MLA Handbook (7th Edition):
Mares, Alina. “Study of the endoplasmic reticulum proteostasis network
during ageing.” 2013. Web. 10 Apr 2021.
Vancouver:
Mares A. Study of the endoplasmic reticulum proteostasis network
during ageing. [Internet] [Doctoral dissertation]. University of Manchester; 2013. [cited 2021 Apr 10].
Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:189372.
Council of Science Editors:
Mares A. Study of the endoplasmic reticulum proteostasis network
during ageing. [Doctoral Dissertation]. University of Manchester; 2013. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:189372

University of Edinburgh
30.
Mackay, Sophie.
False Memory in Ageing: Comparing False Recognition to Semantically and Perceptually Similar Words.
Degree: 2012, University of Edinburgh
URL: http://hdl.handle.net/1842/8387
► Older adults are more susceptible to gist-based false memories. According to Koutstaal et als’ (2003) semantic categorisation account this is because, in situations where both…
(more)
▼ Older adults are more susceptible to gist-based false memories. According to Koutstaal et als’ (2003) semantic categorisation account this is because, in situations where both semantic and perceptual information is present i.e. conceptually related picture recognition, older adults tend to focus on the semantic information at the expense of the perceptual. It was unclear, however, whether this would apply to a situation, such as word lists, where the processing of precise perceptual information was less essential. False recognition rates for semantically and perceptually similar and perceptually similar only words were therefore compared. Analysis revealed no age interactions. This suggests that older adults, rather than demonstrating a generalised vulnerability to gist based false memories, are only disadvantaged when the processing of precise perceptual information is necessary. Limitations of the experiment are discussed.
Advisors/Committee Members: Morcom, Alexa.
Subjects/Keywords: False memory; Ageing
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Mackay, S. (2012). False Memory in Ageing: Comparing False Recognition to Semantically and Perceptually Similar Words. (Thesis). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/8387
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Mackay, Sophie. “False Memory in Ageing: Comparing False Recognition to Semantically and Perceptually Similar Words.” 2012. Thesis, University of Edinburgh. Accessed April 10, 2021.
http://hdl.handle.net/1842/8387.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Mackay, Sophie. “False Memory in Ageing: Comparing False Recognition to Semantically and Perceptually Similar Words.” 2012. Web. 10 Apr 2021.
Vancouver:
Mackay S. False Memory in Ageing: Comparing False Recognition to Semantically and Perceptually Similar Words. [Internet] [Thesis]. University of Edinburgh; 2012. [cited 2021 Apr 10].
Available from: http://hdl.handle.net/1842/8387.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Mackay S. False Memory in Ageing: Comparing False Recognition to Semantically and Perceptually Similar Words. [Thesis]. University of Edinburgh; 2012. Available from: http://hdl.handle.net/1842/8387
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
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