subject:(adverse drug reactions)

1. Alexoudi, Iliana. Φαρμακευτικές αντιδράσεις σε HIV ασθενείς.

Degree: 2018, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)

URL: http://hdl.handle.net/10442/hedi/44785

► This is a retrospective study performed in Andreas Syggros Hospital, a tertiary medical center of Athens, Greece. We found that the incidence of drug reactions… (more)

▼ This is a retrospective study performed in Andreas Syggros Hospital, a tertiary medical center of Athens, Greece. We found that the incidence of drug reactions in our patient population who had initiated ART was highest during the period of introduction of triple therapy in the years 1997–2006 and has subsequently declined over time with the availability of the more recent treatment regimens. Lipodystrophy and maculopapular rashes represented most of drug-related dermatological conditions. Our results are in line with evidence showing a better tolerability of the novel antiretroviral agents introduced since 2007 with a similar or enhanced virological efficacy. 108,114 Patients on ART have been described in several studies as showing a higher incidence of adverse drug reactions when compared to HIV-negative individuals. These reactions are estimated to be 100 times more common, and generally occur during the first year of treatment. The reason behind this increased incidence is believed to be multifactorial. 48,104 In our study HIV treatment-related dermatological conditions were observed in 352/1329 or 26.48% of ART-treated patients, which is substantially higher than in the general population where it is estimated to be 0–8%.46,49 The number of affected men was 299 out of a total of 1155 (25.9%) who were on ART and 53 women of 174 women (30.4%), with no difference noted between sexes (χ2=1.62, P=0.20) although the total number of affected women was small.We have divided the distribution of drug reactions into three time periods, which coincided with changes in the main type of ART prescribed. The first peak period is observed in the period 1988–1996, the second in 1997–2006 and the third in 2007–2013 (Graph.5). Table 8 reflects the change of drug-reaction incidence per period. The first period was characterized by maculopapular eruptions, attributed mostly to the administration of TMP-SMX, whereas NVP was the major causative agent for those observed during the second peak period. Lipodystrophy and maculopapular drug reactions attributed to NVP and other ART medications were mostly observed during the second ART period. TMP-SMX still accounted for some maculopapular rashes, but the majority of them were then linked to NVP use that started in 1998. According to some studies, the incidence of NVP-related reactions seemed to be double in women compared to men.50 In our study there were 44 cases, of which 13 were in women and 31 in men. When corrected for the total number of men and women receiving NVP, the incidence was 15% in women and 7.5% in men (P=0.03, RR=2077, CI 95% 1135–3799), which is in accordance with previous studies. We believe that the decrease in TMP-SMX-related eruptions observed during the second ART period was a result of the introduction of combination ART, which decreased the need for chemoprophylaxis. Lipodystrophy peaked during 1998–2006. Combination ART was introduced in Greece in 1996 and recording of lipodystrophy began in 1998. Lipodystrophy is known to be a metabolic evolutionary process and…

Subjects/Keywords: Φαρμακευτικές αντιδράσεις; Adverse drug reactions

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APA (6^th Edition):

Alexoudi, I. (2018). Φαρμακευτικές αντιδράσεις σε HIV ασθενείς. (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/44785

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Alexoudi, Iliana. “Φαρμακευτικές αντιδράσεις σε HIV ασθενείς.” 2018. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed April 18, 2021. http://hdl.handle.net/10442/hedi/44785.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Alexoudi, Iliana. “Φαρμακευτικές αντιδράσεις σε HIV ασθενείς.” 2018. Web. 18 Apr 2021.

Vancouver:

Alexoudi I. Φαρμακευτικές αντιδράσεις σε HIV ασθενείς. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2018. [cited 2021 Apr 18]. Available from: http://hdl.handle.net/10442/hedi/44785.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Alexoudi I. Φαρμακευτικές αντιδράσεις σε HIV ασθενείς. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2018. Available from: http://hdl.handle.net/10442/hedi/44785

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Penn State University

2. Davaasuren, Dolzodmaa. Analysis of Opioid Related Adverse Events and Signal Detection with Machine Learning.

Degree: 2019, Penn State University

URL: https://submit-etda.libraries.psu.edu/catalog/16880dud240

► In the past 30 years, the United States has experienced an unprecedented opioid epidemic. It’s been reported that physicians dispense more than 650,000 opioid prescriptions… (more)

▼ In the past 30 years, the United States has experienced an unprecedented opioid epidemic. It’s been reported that physicians dispense more than 650,000 opioid prescriptions per average day, according to [1]. Opioids are the most popular choice of drugs of pain management due to its high efficacy. However, their usage is commonly associated with a variety of adverse drug events (ADEs), ranging from nausea and vomiting to urinary retention and respiratory depression. It’s been reported that nearly 10% of total Adverse Drug Events are associated with opioids [2]. Therefore, it is crucial to detect patterns in opioid-related ADEs based on patient information. In this thesis, we present a data-driven approach to detect any opioid-related serious outcomes given a limited amount of information about the patients’ medical history and demographic information. We are using the FDA’s Adverse Event Reporting database (FAERS). FAERS database contains the quarterly released reports made of individual components such as drug, patient demographics, drug indications, drug-related reactions, and resulting outcome data. First of all, we performed extensive data pre-processing on each individual dataset to make it a cleaner, normalized, and more informative. Secondly, we analyzed each dataset more in-depth with basic data mining methods to get preliminary results and insights about the opioid-related adverse events. Lastly, we used an unsupervised clustering method to detect most informative distinct clusters of reports in the pool and found out different types of most common observations in the database. Additionally, random tree classifiers and deep neural networks were used to predict a seriousness of outcome (DE–death) and serious drug reactions such as renal impairment, medication error, death, and congenital disorder and gastrointestinal disorder. Despite the small number of signals, these methods showed relatively high accuracy in detecting abnormal reactions. Also, we developed a way to measure the similarity between two reports, the one with known DDIs and the other without known DDIs. As a result, we found out potential undocumented DDIs using a drug to drug structure similarity and rate of common reactions among each report pair. Advisors/Committee Members: Soundar Kumara, Thesis Advisor/Co-Advisor, Robert Voigt, Committee Member.

Subjects/Keywords: Opioid drugs; Adverse Drug Events; Adverse Drug Reactions; Drug-Drug Interaction

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APA (6^th Edition):

Davaasuren, D. (2019). Analysis of Opioid Related Adverse Events and Signal Detection with Machine Learning. (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/16880dud240

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Davaasuren, Dolzodmaa. “Analysis of Opioid Related Adverse Events and Signal Detection with Machine Learning.” 2019. Thesis, Penn State University. Accessed April 18, 2021. https://submit-etda.libraries.psu.edu/catalog/16880dud240.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Davaasuren, Dolzodmaa. “Analysis of Opioid Related Adverse Events and Signal Detection with Machine Learning.” 2019. Web. 18 Apr 2021.

Vancouver:

Davaasuren D. Analysis of Opioid Related Adverse Events and Signal Detection with Machine Learning. [Internet] [Thesis]. Penn State University; 2019. [cited 2021 Apr 18]. Available from: https://submit-etda.libraries.psu.edu/catalog/16880dud240.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Davaasuren D. Analysis of Opioid Related Adverse Events and Signal Detection with Machine Learning. [Thesis]. Penn State University; 2019. Available from: https://submit-etda.libraries.psu.edu/catalog/16880dud240

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Toronto

3. Novalen, Maria. Investigation of a Metabolic Pathway Leading to an Idiosyncratic Drug Reaction: Is the Sulfate of 12-Hydroxynevirapine Responsible for the Skin Rash in Brown Norway rats?.

Degree: 2010, University of Toronto

URL: http://hdl.handle.net/1807/25882

►

An animal model of nevirapine (NVP)-induced skin rash was used to test the hypothesis that sulfonation of 12-OH NVP, a metabolite of NVP proven essential… (more)

Subjects/Keywords: nevirapine; drug metabolism; adverse drug reactions; idiosyncratic drug reactions; 0383

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Novalen, M. (2010). Investigation of a Metabolic Pathway Leading to an Idiosyncratic Drug Reaction: Is the Sulfate of 12-Hydroxynevirapine Responsible for the Skin Rash in Brown Norway rats?. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/25882

Chicago Manual of Style (16^th Edition):

Novalen, Maria. “Investigation of a Metabolic Pathway Leading to an Idiosyncratic Drug Reaction: Is the Sulfate of 12-Hydroxynevirapine Responsible for the Skin Rash in Brown Norway rats?.” 2010. Masters Thesis, University of Toronto. Accessed April 18, 2021. http://hdl.handle.net/1807/25882.

MLA Handbook (7^th Edition):

Novalen, Maria. “Investigation of a Metabolic Pathway Leading to an Idiosyncratic Drug Reaction: Is the Sulfate of 12-Hydroxynevirapine Responsible for the Skin Rash in Brown Norway rats?.” 2010. Web. 18 Apr 2021.

Vancouver:

Novalen M. Investigation of a Metabolic Pathway Leading to an Idiosyncratic Drug Reaction: Is the Sulfate of 12-Hydroxynevirapine Responsible for the Skin Rash in Brown Norway rats?. [Internet] [Masters thesis]. University of Toronto; 2010. [cited 2021 Apr 18]. Available from: http://hdl.handle.net/1807/25882.

Council of Science Editors:

Novalen M. Investigation of a Metabolic Pathway Leading to an Idiosyncratic Drug Reaction: Is the Sulfate of 12-Hydroxynevirapine Responsible for the Skin Rash in Brown Norway rats?. [Masters Thesis]. University of Toronto; 2010. Available from: http://hdl.handle.net/1807/25882

University of KwaZulu-Natal

4. Kaja, Humraaz. The safety profile of Vilazodone: a study on post-marketing surveillance.

Degree: 2020, University of KwaZulu-Natal

URL: https://researchspace.ukzn.ac.za/handle/10413/19010

► Vilazodone was approved in 2011 as an antidepressant to treat major depressive disorder. Like other antidepressants, vilazodone has adverse effects associated with the use of… (more)

Subjects/Keywords: Vilazodone - adverse drug reactions.; Major depressive disorder - adverse drug reactions.; Antidepressants - adverse drug reactions.; Antidepressants - post-marketing surveillance.

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APA (6^th Edition):

Kaja, H. (2020). The safety profile of Vilazodone: a study on post-marketing surveillance. (Thesis). University of KwaZulu-Natal. Retrieved from https://researchspace.ukzn.ac.za/handle/10413/19010

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kaja, Humraaz. “The safety profile of Vilazodone: a study on post-marketing surveillance.” 2020. Thesis, University of KwaZulu-Natal. Accessed April 18, 2021. https://researchspace.ukzn.ac.za/handle/10413/19010.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kaja, Humraaz. “The safety profile of Vilazodone: a study on post-marketing surveillance.” 2020. Web. 18 Apr 2021.

Vancouver:

Kaja H. The safety profile of Vilazodone: a study on post-marketing surveillance. [Internet] [Thesis]. University of KwaZulu-Natal; 2020. [cited 2021 Apr 18]. Available from: https://researchspace.ukzn.ac.za/handle/10413/19010.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kaja H. The safety profile of Vilazodone: a study on post-marketing surveillance. [Thesis]. University of KwaZulu-Natal; 2020. Available from: https://researchspace.ukzn.ac.za/handle/10413/19010

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Tasmania

5. Parameswaran Nair, N. Hospitalisation in older patients due to adverse drug reactions.

Degree: 2018, University of Tasmania

URL: https://eprints.utas.edu.au/28463/1/Parameswaran_Nair_whole_thesis.pdf ; Parameswaran Nair, N ORCID: 0000-0002-0202-6453 <https://orcid.org/0000-0002-0202-6453> 2018 , 'Hospitalisation in older patients due to adverse drug reactions', PhD thesis, University of Tasmania.

► Medication safety at various stages of the patient journey continues to be a significant problem. The increasingly ageing population worldwide, together with the growing use… (more)

▼ Medication safety at various stages of the patient journey continues to be a significant problem. The increasingly ageing population worldwide, together with the growing use of multiple medications, leads to an increased risk of medication‐related problems. In Australia, the proportion of all hospital admissions that are medication-related is between 2% and 3%. Adverse drug reactions (ADRs) are the most common medication-related problems causing significant morbidity and mortality. Based on data collected from general practitioners’ encounters in 2003 and 2004 in Australia, ADRs represented the most common adverse drug event in the community (72%). Older patients are particularly susceptible to ADRs due to multiple comorbidities, cognitive and functional impairment, a high prevalence of polypharmacy, and age-related changes in pharmacokinetics and pharmacodynamics. Of particular concern are ADR-related hospital admissions which are one of the main reasons for hospitalisation in older patients living in the community. More than half of these ADR-related admissions are considered preventable. Even though several methods of ADR identification exist, prospective and intensive monitoring methods using patient interviews usually have the highest ADR detection rate and allow more accurate recording of both drug history and symptoms for assessing the causality of ADRs. A prospective cross-sectional survey in Australia (1998) estimated that 13.3% of elderly admissions to medical wards were ADR-related. A recent meta-analysis found that one in ten hospital admissions in older patients were due to ADRs. Despite the current efforts to identify and prevent ADRs, the burden of ADRs is continuing. A secondary data analysis of case series in Australia (1981-2002) found that hospital admissions due to ADRs in elderly patients had increased despite programs to promote rational and safer use of medicines. In addition to this burden, ADRs that result in hospitalisation in patients with a history of ADR-related hospitalisation, or ‘repeat ADRs’ are also increasingly common and an important contributor to the burden of ADRs. A population-based longitudinal study (1980-2003) in Australia found that repeat ADRrelated hospitalisations had increased faster than first-time ADRs in the elderly since 1980 and were responsible for 30.3% of all ADR-related admissions in 2003. Hence, strategies to reduce the risk of ADR-related admissions, as well as repeat admissions due to ADRs, are required to reduce the global burden of ADR-related admissions, especially in the elderly. While various strategies including medication review, avoiding use of potentially inappropriate medications, computer-based prescribing systems, and comprehensive geriatric assessment have been suggested, health professionals are not able to easily identify elderly community-dwelling outpatients who are at high risk of being hospitalised due to an ADR. To our knowledge, there are no empirical data that allow stratification of community-dwelling older people according to the…

Subjects/Keywords: adverse drug reactions; hospital admission; prediction; elderly

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APA (6^th Edition):

Parameswaran Nair, N. (2018). Hospitalisation in older patients due to adverse drug reactions. (Thesis). University of Tasmania. Retrieved from https://eprints.utas.edu.au/28463/1/Parameswaran_Nair_whole_thesis.pdf ; Parameswaran Nair, N ORCID: 0000-0002-0202-6453 <https://orcid.org/0000-0002-0202-6453> 2018 , 'Hospitalisation in older patients due to adverse drug reactions', PhD thesis, University of Tasmania.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Parameswaran Nair, N. “Hospitalisation in older patients due to adverse drug reactions.” 2018. Thesis, University of Tasmania. Accessed April 18, 2021. https://eprints.utas.edu.au/28463/1/Parameswaran_Nair_whole_thesis.pdf ; Parameswaran Nair, N ORCID: 0000-0002-0202-6453 <https://orcid.org/0000-0002-0202-6453> 2018 , 'Hospitalisation in older patients due to adverse drug reactions', PhD thesis, University of Tasmania..

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Parameswaran Nair, N. “Hospitalisation in older patients due to adverse drug reactions.” 2018. Web. 18 Apr 2021.

Vancouver:

Parameswaran Nair N. Hospitalisation in older patients due to adverse drug reactions. [Internet] [Thesis]. University of Tasmania; 2018. [cited 2021 Apr 18]. Available from: https://eprints.utas.edu.au/28463/1/Parameswaran_Nair_whole_thesis.pdf ; Parameswaran Nair, N ORCID: 0000-0002-0202-6453 <https://orcid.org/0000-0002-0202-6453> 2018 , 'Hospitalisation in older patients due to adverse drug reactions', PhD thesis, University of Tasmania..

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Parameswaran Nair N. Hospitalisation in older patients due to adverse drug reactions. [Thesis]. University of Tasmania; 2018. Available from: https://eprints.utas.edu.au/28463/1/Parameswaran_Nair_whole_thesis.pdf ; Parameswaran Nair, N ORCID: 0000-0002-0202-6453 <https://orcid.org/0000-0002-0202-6453> 2018 , 'Hospitalisation in older patients due to adverse drug reactions', PhD thesis, University of Tasmania.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of KwaZulu-Natal

6. Prosad, Shimona. Experiences of Implanon NXT® users at public health facilities in South Africa.

Degree: 2018, University of KwaZulu-Natal

URL: https://researchspace.ukzn.ac.za/handle/10413/18463

► Background and aim: Implanon NXT® was introduced in South Africa (SA) in the public health sector in February 2014. There exist concerns with premature Implanon… (more)

▼ Background and aim: Implanon NXT® was introduced in South Africa (SA) in the public health sector in February 2014. There exist concerns with premature Implanon NXT® user discontinuation in SA however, the true extent remains unknown due to delayed monitoring systems and limited empirical data. This study aimed to evaluate the experiences of Implanon NXT® among users in the public health sector in SA. Methods: A retrospective study was conducted and entailed analysis of secondary data attained from the National Department of Health Pharmacovigilance Centre for Public Health Programmes using reports submitted from 1 April 2015 to 11 September 2017. A total of 3743 cases were extracted and analysed using SPSS®. Tests of association were performed using demographics, adverse drug reactions and discontinuation variables. Chi square test and Mann Whitney U-Test were performed to test differences between Gauteng and KwaZulu-Natal (KZN). Results: The 20-24-year olds were the most frequent Implanon NXT® users (25.70%; 962/3743). Of the 36.57% (1369/3743) cases which reported adverse drug reactions (ADRs), menorrhagia (52.01%;712/1369), headache (20.45%;280/1369) and dizziness (11.18%;153/1369) were the most frequent ADRs. Discontinuation was reported by 63.56% (2379/3743) of case reports and premature discontinuation was reported by 81.1% (1210/1492). The common reasons for discontinuation were menorrhagia (34.27%;728/2124), expiry (29.57%;628/2124) and headache (10.26%;218/2124). Overall, ADRs were found to be the main reason for discontinuation (83.99%; 1784/2124). Pregnancies reported with Implanon NXT® occurred in 4.97% (68/1369) of case reports and efavirenz-based therapy was suspected to be associated with pregnancy in Implanon NXT® users (p<0.001). The common ADRs and reasons for discontinuation of Implanon NXT® reported in Gauteng was consistent with the national data while drug interaction and pregnancy were commonly reported in KZN. Premature discontinuation of Implanon NXT® was higher in Gauteng (82.6%, 252/305) than KZN (76.7%, 23/30). Conclusion: Young women were frequent users of Implanon NXT® . Menorrhagia was the predominantly reported ADR among all the users. A high frequency of discontinuation was identified, and ADRs were mainly responsible for discontinuation. The frequency of failure was small and efavirenz was suspected to be associated. The experiences of Implanon NXT® users differed between KZN and Gauteng which emphasizes tailored strategies need to be considered. Users’ counselling, adverse drug reaction treatment and management, monitoring and evaluation are recommended to address high discontinuation in SA. Advisors/Committee Members: Ojewole, Elizabeth Bolanle. (advisor).

Subjects/Keywords: Contraception.; Implanon NXT®.; Adverse drug reactions.; Adverse drug reactions.; Pharmacovigilance.; South Africa.

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APA (6^th Edition):

Prosad, S. (2018). Experiences of Implanon NXT® users at public health facilities in South Africa. (Thesis). University of KwaZulu-Natal. Retrieved from https://researchspace.ukzn.ac.za/handle/10413/18463

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Prosad, Shimona. “Experiences of Implanon NXT® users at public health facilities in South Africa.” 2018. Thesis, University of KwaZulu-Natal. Accessed April 18, 2021. https://researchspace.ukzn.ac.za/handle/10413/18463.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Prosad, Shimona. “Experiences of Implanon NXT® users at public health facilities in South Africa.” 2018. Web. 18 Apr 2021.

Vancouver:

Prosad S. Experiences of Implanon NXT® users at public health facilities in South Africa. [Internet] [Thesis]. University of KwaZulu-Natal; 2018. [cited 2021 Apr 18]. Available from: https://researchspace.ukzn.ac.za/handle/10413/18463.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Prosad S. Experiences of Implanon NXT® users at public health facilities in South Africa. [Thesis]. University of KwaZulu-Natal; 2018. Available from: https://researchspace.ukzn.ac.za/handle/10413/18463

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of KwaZulu-Natal

7. Ndlovu, Garnet. Awareness and knowledge of doctors, pharmacists and nurses on adverse drug reaction reporting systems in Namibia.

Degree: 2020, University of KwaZulu-Natal

URL: https://researchspace.ukzn.ac.za/handle/10413/19015

► Objective Reporting of adverse drug reactions (ADRs) in Namibian public health facilities is routinely done through safety yellow forms which are forwarded to the Therapeutics… (more)

▼ Objective Reporting of adverse drug reactions (ADRs) in Namibian public health facilities is routinely done through safety yellow forms which are forwarded to the Therapeutics Information and Pharmacovigilance Centre (TIPC) for further assessment and possible interventions. This study investigated the awareness and knowledge of healthcare practitioners (HCPs) regarding the ADR reporting system in the country. Methods A cross-sectional study was conducted via a self-administered questionnaire at two state hospitals in Namibia; one located in the Khomas region and the other located in the Hardap region. The questionnaire was distributed to HCPs in current practice dealing directly with medication and it included a combination of open-ended, closed-ended and multiple-choice questions. Questionnaires were distributed in hard copy form during the period of 1 October 2019 up until 15 December 2019. Data was coded and transcribed into Microsoft® Excel® 2016 and analysed with SPSS® for IOS version 24. Results One-hundred and three completed questionnaires were received. Sixty-eight percent of the respondents were nurses, 24.3% were medical doctors and 7.8% were pharmacists. The majority of HCPs (73.8% and 56.3% respectively) were able to define the terms “adverse drug reaction” and “pharmacovigilance” correctly while only 41.7% correctly defined “spontaneous reporting”. The majority of HCPs (60.2%) have identified an ADR in practice; however only 36.9% reported this following the approved process. Only 48.5% of HCPs were aware of the safety yellow form for ADRs and 63.1% of HCPs did not know where to obtain the form. Furthermore only 37.9% of HCPs knew the name of the drug regulatory authority in Namibia. Conclusion Awareness and knowledge of ADR reporting systems by HCPs in Namibia is insufficient. While HCPs deem it necessary to report ADRs, reporting is unacceptably low leading to serious concerns regarding continuous monitoring of drug safety. Pharmacists showed better awareness compared to other HCPs and can, therefore, be best utilised as focal points in pharmacovigilance protraction. Mass awareness programs by the TIPC and other stakeholders need to be established to expand pharmacovigilance among HCPs. Advisors/Committee Members: Oosthuizen, Frasia. (advisor), Bangalee, Varsha. (advisor).

Subjects/Keywords: Adverse drug reactions - awareness and reporting - healthcare professionals - Namibia.; Pharmacovigilance - Namibia.; Adverse drug reactions - knowledge - healthcare professionals - Namibia.; Drug safety - Namibia.

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APA (6^th Edition):

Ndlovu, G. (2020). Awareness and knowledge of doctors, pharmacists and nurses on adverse drug reaction reporting systems in Namibia. (Thesis). University of KwaZulu-Natal. Retrieved from https://researchspace.ukzn.ac.za/handle/10413/19015

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ndlovu, Garnet. “Awareness and knowledge of doctors, pharmacists and nurses on adverse drug reaction reporting systems in Namibia.” 2020. Thesis, University of KwaZulu-Natal. Accessed April 18, 2021. https://researchspace.ukzn.ac.za/handle/10413/19015.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ndlovu, Garnet. “Awareness and knowledge of doctors, pharmacists and nurses on adverse drug reaction reporting systems in Namibia.” 2020. Web. 18 Apr 2021.

Vancouver:

Ndlovu G. Awareness and knowledge of doctors, pharmacists and nurses on adverse drug reaction reporting systems in Namibia. [Internet] [Thesis]. University of KwaZulu-Natal; 2020. [cited 2021 Apr 18]. Available from: https://researchspace.ukzn.ac.za/handle/10413/19015.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ndlovu G. Awareness and knowledge of doctors, pharmacists and nurses on adverse drug reaction reporting systems in Namibia. [Thesis]. University of KwaZulu-Natal; 2020. Available from: https://researchspace.ukzn.ac.za/handle/10413/19015

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Cambridge

8. Smit, Ines. Associating adverse drug effects with protein targets by integrating adverse event, in vitro bioactivity, and pharmacokinetic data.

Degree: PhD, 2020, University of Cambridge

URL: https://doi.org/10.17863/CAM.65132 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.824363

► Adverse drug effects are unintended and undesirable effects of medicines, causing attrition of molecules in drug development and harm to patients. To anticipate potential adverse… (more)

▼ Adverse drug effects are unintended and undesirable effects of medicines, causing attrition of molecules in drug development and harm to patients. To anticipate potential adverse effects early, drug candidates are commonly screened for pharmacological activity against a panel of protein targets. However, there is a lack of large-scale, quantitative information on the links between routinely screened proteins and the reporting of adverse events (AEs). This work describes a systematic analysis of associations between AEs observed in humans and bioactivities of drugs while taking into account drug plasma concentrations. In the first chapter, post-marketing drug-AE associations are derived from the United States Food and Drug Administration Adverse Event Reporting System using disproportionality methods, while applying Propensity Score Matching to reduce confounding factors. The resulting drug-AE associations are compared to those from the Side Effect Resource, which are primarily derived from clinical trials. The analysis reveals that the datasets generally share less than 10% of reported AEs for the same drug and have different distributions of AEs across System Organ Classes (SOCs). Using the drugs from the two AE datasets described in the first chapter, the second chapter integrates corresponding bioactivities, i.e. measured potencies and affinities from the ChEMBL database and ligand-based target predictions obtained with the tool PIDGIN, with drug plasma concentrations compiled from literature, such as Cmax. Compared to a constant bioactivity cut-off of 1 uM, using the ratio of the unbound drug plasma concentration over the drug potency, i.e. Cmax/XC50, results in different binary activity calls for protein targets. Whether deriving activity calls in this way results in the selection of targets with greater relevance to human AEs is investigated in the third chapter, which computes relationships between targets and AEs using different measures of statistical association. Using the Cmax/XC50 ratio results in higher Likelihood Ratios and Positive Predictive Values (PPVs) for target-AE associations that were previously reported in the context of secondary pharmacology screening, at the cost of a lower recall, possibly due to the smaller size of the dataset with available plasma concentrations. Furthermore, a large-scale quantitative assessment of bioactivities as indicators of AEs reveals a trade-off between the PPV and how many AE-associated drugs can potentially be detected from in vitro screening, although using combinations of targets can improve the detection rate in ~40% of cases at limited cost to the PPV. The work highlights AEs most strongly related to bioactivities and their SOC distribution. Overall, this thesis contributes to knowledge of the relationships between in vitro bioactivities and empirical evidence of AEs in humans. The results can inform the selection of proteins for secondary pharmacology screening and the development of computational models to predict AEs.

Subjects/Keywords: Adverse drug reactions; Secondary pharmacology; FDA Adverse Event Reporting System; SIDER; Drug safety

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Smit, I. (2020). Associating adverse drug effects with protein targets by integrating adverse event, in vitro bioactivity, and pharmacokinetic data. (Doctoral Dissertation). University of Cambridge. Retrieved from https://doi.org/10.17863/CAM.65132 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.824363

Chicago Manual of Style (16^th Edition):

Smit, Ines. “Associating adverse drug effects with protein targets by integrating adverse event, in vitro bioactivity, and pharmacokinetic data.” 2020. Doctoral Dissertation, University of Cambridge. Accessed April 18, 2021. https://doi.org/10.17863/CAM.65132 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.824363.

MLA Handbook (7^th Edition):

Smit, Ines. “Associating adverse drug effects with protein targets by integrating adverse event, in vitro bioactivity, and pharmacokinetic data.” 2020. Web. 18 Apr 2021.

Vancouver:

Smit I. Associating adverse drug effects with protein targets by integrating adverse event, in vitro bioactivity, and pharmacokinetic data. [Internet] [Doctoral dissertation]. University of Cambridge; 2020. [cited 2021 Apr 18]. Available from: https://doi.org/10.17863/CAM.65132 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.824363.

Council of Science Editors:

Smit I. Associating adverse drug effects with protein targets by integrating adverse event, in vitro bioactivity, and pharmacokinetic data. [Doctoral Dissertation]. University of Cambridge; 2020. Available from: https://doi.org/10.17863/CAM.65132 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.824363

University of Cambridge

9. Smit, Ines. Associating adverse drug effects with protein targets by integrating adverse event, in vitro bioactivity, and pharmacokinetic data.

Degree: PhD, 2020, University of Cambridge

URL: https://www.repository.cam.ac.uk/handle/1810/318018

► Adverse drug effects are unintended and undesirable effects of medicines, causing attrition of molecules in drug development and harm to patients. To anticipate potential adverse… (more)

▼ Adverse drug effects are unintended and undesirable effects of medicines, causing attrition of molecules in drug development and harm to patients. To anticipate potential adverse effects early, drug candidates are commonly screened for pharmacological activity against a panel of protein targets. However, there is a lack of large-scale, quantitative information on the links between routinely screened proteins and the reporting of adverse events (AEs). This work describes a systematic analysis of associations between AEs observed in humans and bioactivities of drugs while taking into account drug plasma concentrations. In the first chapter, post-marketing drug-AE associations are derived from the United States Food and Drug Administration Adverse Event Reporting System using disproportionality methods, while applying Propensity Score Matching to reduce confounding factors. The resulting drug-AE associations are compared to those from the Side Effect Resource, which are primarily derived from clinical trials. The analysis reveals that the datasets generally share less than 10% of reported AEs for the same drug and have different distributions of AEs across System Organ Classes (SOCs). Using the drugs from the two AE datasets described in the first chapter, the second chapter integrates corresponding bioactivities, i.e. measured potencies and affinities from the ChEMBL database and ligand-based target predictions obtained with the tool PIDGIN, with drug plasma concentrations compiled from literature, such as Cmax. Compared to a constant bioactivity cut-off of 1 uM, using the ratio of the unbound drug plasma concentration over the drug potency, i.e. Cmax/XC50, results in different binary activity calls for protein targets. Whether deriving activity calls in this way results in the selection of targets with greater relevance to human AEs is investigated in the third chapter, which computes relationships between targets and AEs using different measures of statistical association. Using the Cmax/XC50 ratio results in higher Likelihood Ratios and Positive Predictive Values (PPVs) for target-AE associations that were previously reported in the context of secondary pharmacology screening, at the cost of a lower recall, possibly due to the smaller size of the dataset with available plasma concentrations. Furthermore, a large-scale quantitative assessment of bioactivities as indicators of AEs reveals a trade-off between the PPV and how many AE-associated drugs can potentially be detected from in vitro screening, although using combinations of targets can improve the detection rate in ~40% of cases at limited cost to the PPV. The work highlights AEs most strongly related to bioactivities and their SOC distribution. Overall, this thesis contributes to knowledge of the relationships between in vitro bioactivities and empirical evidence of AEs in humans. The results can inform the selection of proteins for secondary pharmacology screening and the development of computational models to predict AEs.

Subjects/Keywords: Adverse drug reactions; Secondary pharmacology; FDA Adverse Event Reporting System; SIDER; Drug safety

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Smit, I. (2020). Associating adverse drug effects with protein targets by integrating adverse event, in vitro bioactivity, and pharmacokinetic data. (Doctoral Dissertation). University of Cambridge. Retrieved from https://www.repository.cam.ac.uk/handle/1810/318018

Chicago Manual of Style (16^th Edition):

Smit, Ines. “Associating adverse drug effects with protein targets by integrating adverse event, in vitro bioactivity, and pharmacokinetic data.” 2020. Doctoral Dissertation, University of Cambridge. Accessed April 18, 2021. https://www.repository.cam.ac.uk/handle/1810/318018.

MLA Handbook (7^th Edition):

Smit, Ines. “Associating adverse drug effects with protein targets by integrating adverse event, in vitro bioactivity, and pharmacokinetic data.” 2020. Web. 18 Apr 2021.

Vancouver:

Smit I. Associating adverse drug effects with protein targets by integrating adverse event, in vitro bioactivity, and pharmacokinetic data. [Internet] [Doctoral dissertation]. University of Cambridge; 2020. [cited 2021 Apr 18]. Available from: https://www.repository.cam.ac.uk/handle/1810/318018.

Council of Science Editors:

Smit I. Associating adverse drug effects with protein targets by integrating adverse event, in vitro bioactivity, and pharmacokinetic data. [Doctoral Dissertation]. University of Cambridge; 2020. Available from: https://www.repository.cam.ac.uk/handle/1810/318018

10. Stankūnaitė, Jurga. Skubių hospitalizacijų dėl nepageidaujamų reakcijų į vaistą analizė.

Degree: Master, Pharmacy, 2014, Lithuanian Academic Libraries Network (LABT)

URL: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2014~D_20140630_133542-68573 ;

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Darbo tikslas: ištirti hospitalizacijų dėl vaistų sukeltų nepageidaujamų reakcijų ypatybes bei dėsningumus. Uždaviniai: 1) nustatyti hospitalizacijų dėl NRV dažnumą, sunkumą bei įvertinti pasekmes; 2) identifikuoti… (more)

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Darbo tikslas: ištirti hospitalizacijų dėl vaistų sukeltų nepageidaujamų reakcijų ypatybes bei dėsningumus. Uždaviniai: 1) nustatyti hospitalizacijų dėl NRV dažnumą, sunkumą bei įvertinti pasekmes; 2) identifikuoti vaistų grupes, dėl kurių sukeltų NRV ligonius dažniausiai reikia hospitalizuoti; 3) nustatyti priežastis, kurios galėjo padidinti hospitalizacijų dėl NRV dažnį; 4) nustatyti rizikos veiksnius, kurie gali didinti hospitalizacijų dėl NRV dažnį; 5) paruošti praktines rekomendacijas, kaip sumažinti hospitalizacijų dėl NRV dažnį. Metodika: buvo peržiūrimos pacientų, kurie per 5 mėnesius gydėsi Vidaus ligų diagnostikos skyriuje, ligos istorijos. Įtarus, kad pacientas galėjo būti hospitalizuotas dėl NRV, atvejis būdavo nagrinėjamas. NRV tikėtinumas buvo vertinamas pagal Naranjo tikėtinumo metodą. NRV išvengiamumas buvo nustatynėjamas analizuojant ligos istorijų anamnezes ir kitus paciento duomenis ir vertinamas panaudojant specifinį 10 klausimų klausimyną. Visi duomenys buvo renkami ir apdorojami su statistinės duomenų analizės programos SPSS 20.0 versija. Rezultatai: nustatyta 41 NRV sukelta hospitalizacija (4,4 proc.). 53,7 proc. hospitalizacijų dėl NRV buvo vidutinio intensyvumo (p < 0,05). Nustatyti 3 mirties atvejai (7,3 proc.) dėl NRV hospitalizuotų moterų grupėje. Išgyvenusiems pacientams po NRV sukeltų hospitalizacijų buvo reikalingas papildomas ambulatorinis gydymas (92,8 proc., p < 0,05). 73,2 proc. pasireiškė gretutinių ligų pablogėjimas (p < 0,05), 70,7 proc.... [toliau žr. visą tekstą]

Objective: To examine characteristics and patterns of hospitalizations caused by adverse drug reactions. Methods: During 5 month period, medical records of Internal Diagnostic section patients were evaluated to determine hospitalizations caused by adverse drug reactions. In case of suspicion that the patient could be hospitalized due to adverse drug reaction, the case was examining. Probability was evaluated according to Naranjo Adverse Drug Reaction Probability Scale. Preventability was determined while using specific questioniere from 10 questions. Statistical data was collected and evaluated with SPSS version 20.0. Results: 41 hospitalizations occured due to ADR (4,4%). 53,7% of them were evaluated as mild severity (p < 0,05). 3 deaths (7,3%) occured in hospitalized women group because of ADR. Patients who outlived after ADR hospitalizations were in need of additional out-patient treatment (92,8%, p < 0,05). 73,2% experienced worsening of the underlying diseases (p < 0,05), 70,7% were hospitalized for more than 7 days (p < 0,05). Approximate cost of one hospitalization was 3 617,70 Lt, while others, not related to ADE - 2 729,05 Lt. Most of ADR hospitalzitions were caused by anticoagulants (53,7%, p < 0,05): warfarin (41,5%), acetylsalicylic acid (9,8%). Major reasons which might have enhanced hospitalizations due to ADR risks were evaluated as drug interactions (24,4 proc.), overdose (22,0%), drug use to the discretion of the patient's (17,1%), drug prescribing regardless... [to full text]

Advisors/Committee Members: Gumbrevičius, Gintautas (Master’s thesis supervisor), Rodovičius, Hiliaras (Master’s thesis reviewer), Savickienė, Nijolė (Master’s degree committee chair), Janulis, Valdimaras (Master’s degree committee member), Ivanauskas, Liudas (Master’s degree committee member), Savickas, Arūnas (Master’s degree committee member), Briedis, Vitalis (Master’s degree committee member), Ramanauskienė, Kristina (Master’s degree committee member), Inkėnienė, Asta Marija (Master’s degree committee member), Jakštas, Valdas (Master’s degree committee member), Drakšienė, Gailutė (Master’s degree committee member), Radžiūnas, Raimundas (Master’s degree committee member), Skyrius, Vaidas (Master’s degree committee member), Barsteigienė, Zita (Master’s degree committee member), Marksienė, Rūta (Master’s degree committee member), Brusokas, Valdemaras (Master’s degree committee member), Ževžikovas, Andrejus (Master’s degree committee member), Vitkevičius, Konradas (Master’s degree committee member), Ragažinskienė, Ona (Master’s degree committee member), Maruška, Audrius (Master’s degree committee member), Martinėnas, Žydrūnas (Master’s degree committee member), Kuncaitė, Giedrė (Master’s degree committee member), Zulanienė, Eglė Audronė (Master’s degree committee member), Jakubauskas, Mindaugas (Master’s degree committee member), Budrikienė, Aušra (Master’s degree committee member), Švarcaitė, Jūratė (Master’s degree committee member), Marcinkevičienė, Rasa (Master’s degree committee member), Balanaškienė, Rima (Master’s degree committee member).

Subjects/Keywords: Nepageidaujamos reakcijos; Hospitalizacija; Vaistai; Adverse drug reactions; Hospitaliztions; Drug

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Stankūnaitė, Jurga. (2014). Skubių hospitalizacijų dėl nepageidaujamų reakcijų į vaistą analizė. (Masters Thesis). Lithuanian Academic Libraries Network (LABT). Retrieved from http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2014~D_20140630_133542-68573 ;

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Chicago Manual of Style (16^th Edition):

Stankūnaitė, Jurga. “Skubių hospitalizacijų dėl nepageidaujamų reakcijų į vaistą analizė.” 2014. Masters Thesis, Lithuanian Academic Libraries Network (LABT). Accessed April 18, 2021. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2014~D_20140630_133542-68573 ;.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

MLA Handbook (7^th Edition):

Stankūnaitė, Jurga. “Skubių hospitalizacijų dėl nepageidaujamų reakcijų į vaistą analizė.” 2014. Web. 18 Apr 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

Stankūnaitė, Jurga. Skubių hospitalizacijų dėl nepageidaujamų reakcijų į vaistą analizė. [Internet] [Masters thesis]. Lithuanian Academic Libraries Network (LABT); 2014. [cited 2021 Apr 18]. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2014~D_20140630_133542-68573 ;.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Council of Science Editors:

Stankūnaitė, Jurga. Skubių hospitalizacijų dėl nepageidaujamų reakcijų į vaistą analizė. [Masters Thesis]. Lithuanian Academic Libraries Network (LABT); 2014. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2014~D_20140630_133542-68573 ;

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

University of Oxford

11. Onakpoya, Igho. An evidence-based approach to the post-marketing withdrawal of medicinal products because of adverse reactions.

Degree: PhD, 2017, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:086dcf03-5adc-4cb1-9bc6-59fcba0b8c64 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.729863

► Background: The aim of this thesis was to develop an evidence-based approach to the post-marketing withdrawal of medicinal products when harms are attributed to their… (more)

▼ Background: The aim of this thesis was to develop an evidence-based approach to the post-marketing withdrawal of medicinal products when harms are attributed to their use. Methods: Electronic and non-electronic searches were conducted to identify medicinal products withdrawn from the market because of adverse reactions. Data relating to the time periods between launch, first adverse reaction reports and withdrawals, the mechanism through which the adverse reactions occurred, and the countries of withdrawal were extracted. Standard criteria were used to document the levels of evidence used by drug regulators to make the withdrawal decisions; scatter plots and two-by-two tables used to explore the trends over time. A previously published algorithm was used to examine the justification for withdrawals. To examine the benefits and harms of medicinal products before regulatory approval, searches were conducted on drug regulatory websites and scientific databases. The Cochrane criterion was used to examine the risk of bias, Review Manager Software for meta-analysis, and GRADE criterion to rate the quality of evidence. Results: Improvements in pharmacovigilance over the past six decades have resulted in quicker detection of harms caused by approved medicinal products; however, there have not been corresponding improvements in how quickly harmful products are withdrawn from the market following the reports of harms. Harmful drugs are significantly less likely to be withdrawn in low resource settings. The quality of evidence in drug trials for which regulatory approval decisions are based is on the whole, poor. There is a lack of consistency in the methods used by drug regulators to assess the harms of medicinal products before granting marketing licences. Conclusions: Universally accepted guidelines for deciding when to withdraw approved medicinal products from the market should be developed. Pharmacovigilance systems in low-resource settings should be strengthened. The methods used to assess harms in clinical trials require improvement.

Subjects/Keywords: 615.7; Drug withdrawal; Adverse reactions; Systematic review; Drug withdrawal

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Onakpoya, I. (2017). An evidence-based approach to the post-marketing withdrawal of medicinal products because of adverse reactions. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:086dcf03-5adc-4cb1-9bc6-59fcba0b8c64 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.729863

Chicago Manual of Style (16^th Edition):

Onakpoya, Igho. “An evidence-based approach to the post-marketing withdrawal of medicinal products because of adverse reactions.” 2017. Doctoral Dissertation, University of Oxford. Accessed April 18, 2021. http://ora.ox.ac.uk/objects/uuid:086dcf03-5adc-4cb1-9bc6-59fcba0b8c64 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.729863.

MLA Handbook (7^th Edition):

Onakpoya, Igho. “An evidence-based approach to the post-marketing withdrawal of medicinal products because of adverse reactions.” 2017. Web. 18 Apr 2021.

Vancouver:

Onakpoya I. An evidence-based approach to the post-marketing withdrawal of medicinal products because of adverse reactions. [Internet] [Doctoral dissertation]. University of Oxford; 2017. [cited 2021 Apr 18]. Available from: http://ora.ox.ac.uk/objects/uuid:086dcf03-5adc-4cb1-9bc6-59fcba0b8c64 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.729863.

Council of Science Editors:

Onakpoya I. An evidence-based approach to the post-marketing withdrawal of medicinal products because of adverse reactions. [Doctoral Dissertation]. University of Oxford; 2017. Available from: http://ora.ox.ac.uk/objects/uuid:086dcf03-5adc-4cb1-9bc6-59fcba0b8c64 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.729863

University of Toronto

12. Johnston, Alexander Scott. Insights into the Mechanism of Idiosyncratic Drug-induced Agranulocytosis.

Degree: 2017, University of Toronto

URL: http://hdl.handle.net/1807/77802

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Many drugs are known to cause idiosyncratic drug-induced agranulocytosis, although the mechanism is not well understood. This adverse event is suspected to be the result… (more)

Subjects/Keywords: Adverse Drug Reactions; Agranulocytosis; Animal Model; Clozapine; Idiosyncratic Drug Reactions; Myeloperoxidase; 0383

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Johnston, A. S. (2017). Insights into the Mechanism of Idiosyncratic Drug-induced Agranulocytosis. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/77802

Chicago Manual of Style (16^th Edition):

Johnston, Alexander Scott. “Insights into the Mechanism of Idiosyncratic Drug-induced Agranulocytosis.” 2017. Masters Thesis, University of Toronto. Accessed April 18, 2021. http://hdl.handle.net/1807/77802.

MLA Handbook (7^th Edition):

Johnston, Alexander Scott. “Insights into the Mechanism of Idiosyncratic Drug-induced Agranulocytosis.” 2017. Web. 18 Apr 2021.

Vancouver:

Johnston AS. Insights into the Mechanism of Idiosyncratic Drug-induced Agranulocytosis. [Internet] [Masters thesis]. University of Toronto; 2017. [cited 2021 Apr 18]. Available from: http://hdl.handle.net/1807/77802.

Council of Science Editors:

Johnston AS. Insights into the Mechanism of Idiosyncratic Drug-induced Agranulocytosis. [Masters Thesis]. University of Toronto; 2017. Available from: http://hdl.handle.net/1807/77802

Univerzitet u Beogradu

13. Kovačević, Milena, 1988-, 22718311. Procena učestalosti i prediktora klinički značajnih lek-lek interakcija i njihov uticaj na ishode terapije pacijenata sa kardiovaskularnim oboljenjima.

Degree: Farmaceutski fakultet, 2020, Univerzitet u Beogradu

URL: https://fedorabg.bg.ac.rs/fedora/get/o:22401/bdef:Content/get

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Farmacija - Farmakokinetika i klinička farmacija / Pharmacy - Pharmacokinetics and Clinical Pharmacy

Lek-lek interakcije (LLI) su čest uzrok pojave neželjenih ishoda terapije kroz izmenu… (more)

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Farmacija - Farmakokinetika i klinička farmacija / Pharmacy - Pharmacokinetics and Clinical Pharmacy

Lek-lek interakcije (LLI) su čest uzrok pojave neželjenih ishoda terapije kroz izmenu u efikasnosti ili bezbednosti terapije, a koji se može prevenirati. Posledice LLI nisu dovoljno istražene zbog njihovog neprepoznavanja. Lekovi u terapiji bolesti kardiovaskularnog sistema imaju veliki potencijal za stupanje u LLI, zbog svojih farmakokinetičkih i/ili farmakodinamskih karakteristika. Cilj istraživanja bila je identifikacija potencijalnih i klinički značajnih LLI, procena prevalence, karakteristika i prediktora u populaciji pacijenata sa kardiovaskularnim bolestima, kao i njihov uticaj na ishode terapije. Podaci o pacijentima su prikupljeni retrospektivno iz medicinske dokumentacije. Za identifikaciju LLI korišćena je baza Lexi-Interact, dok je statistička obrada podataka izvršena u programu PASW Statistics. Određena je visoka prevalenca potencijalno relevantnih LLI u populaciji pacijenata sa kardiovaskularnim bolestima, kako u trenutku prijema pacijenata na odeljenje kardiologije (60,7%), tako i tokom bolničkog lečenja (83,9%). Identifikovane su vrste, mehanizam, nivo rizika i stepen ozbiljnosti potencijalnih i ispoljenih LLI, identifikovani su prediktori za njihovu pojavu, izdvojene su subpopulacije pacijenata sa većom prevalencom, i ispitano je prisustvo dodatnih faktora rizika koji povećavaju rizik od manifestacije LLI. Procenjena je primena Lexi-Interact baze kao alata za identifikaciju LLI i optimizaciju terapije izborom alternativnog leka, a razmotrene su i mogućnosti unapređenja alerta uključivanjem karakteristika pacijenata kao modifikatora rizika. Prevalenca klinički značajnih LLI koje su bile povezane sa pojavom neželjenih reakcija na lek u trenutku hospitalizacije pacijenta iznosila je 9,7%. Razvijen je skor koji predviđa verovatnoću budućeg neželjenog događaja usled prisustva kumulativnog rizika od većeg broja potencijalnih LLI. Identifikacija pacijenata sa većim rizikom od pojave neželjenog događaja može olakšati prepoznavanje LLI i unaprediti primenu elektronskih baza podataka u kliničkoj praksi.

Advisors/Committee Members: Miljković, Branislava, 1963-, 12631399.

Subjects/Keywords: adverse drug event; adverse drug reactions; clinical significance; drug-drug interactions; cardiology; patient safety; cardiovascular disease; Lexi-Interact

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kovačević, Milena, 1988-, 2. (2020). Procena učestalosti i prediktora klinički značajnih lek-lek interakcija i njihov uticaj na ishode terapije pacijenata sa kardiovaskularnim oboljenjima. (Thesis). Univerzitet u Beogradu. Retrieved from https://fedorabg.bg.ac.rs/fedora/get/o:22401/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kovačević, Milena, 1988-, 22718311. “Procena učestalosti i prediktora klinički značajnih lek-lek interakcija i njihov uticaj na ishode terapije pacijenata sa kardiovaskularnim oboljenjima.” 2020. Thesis, Univerzitet u Beogradu. Accessed April 18, 2021. https://fedorabg.bg.ac.rs/fedora/get/o:22401/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kovačević, Milena, 1988-, 22718311. “Procena učestalosti i prediktora klinički značajnih lek-lek interakcija i njihov uticaj na ishode terapije pacijenata sa kardiovaskularnim oboljenjima.” 2020. Web. 18 Apr 2021.

Vancouver:

Kovačević, Milena, 1988- 2. Procena učestalosti i prediktora klinički značajnih lek-lek interakcija i njihov uticaj na ishode terapije pacijenata sa kardiovaskularnim oboljenjima. [Internet] [Thesis]. Univerzitet u Beogradu; 2020. [cited 2021 Apr 18]. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:22401/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kovačević, Milena, 1988- 2. Procena učestalosti i prediktora klinički značajnih lek-lek interakcija i njihov uticaj na ishode terapije pacijenata sa kardiovaskularnim oboljenjima. [Thesis]. Univerzitet u Beogradu; 2020. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:22401/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of KwaZulu-Natal

14. Mafundikwa, Tafadzwa Christine. Knowledge, attitudes and practices of community pharmacists in Harare regarding the reporting of adverse drug reactions.

Degree: 2017, University of KwaZulu-Natal

URL: http://hdl.handle.net/10413/15746

► Adverse drug reactions (ADRs) cause considerable morbidity which contributes significantly to health expenditure. Worldwide, there is under-reporting of ADRs by healthcare workers and Zimbabwe is… (more)

▼ Adverse drug reactions (ADRs) cause considerable morbidity which contributes significantly to health expenditure. Worldwide, there is under-reporting of ADRs by healthcare workers and Zimbabwe is no exception. In Zimbabwe, ADRs are mainly detected by use of a spontaneous reporting system. There is a greater need for enhanced pharmacovigilance (PCV) in Africa, where weak health systems are likely to contribute to medicine-related harm. The aim of the study was to contribute to the safe use of medicines by strengthening reporting of adverse drug reactions by pharmacists in Harare, by identifying knowledge, attitudes and practices that hinder their involvement at present. The objectives of the study are to determine if pharmacists practicing in private community pharmacies in Harare, Zimbabwe, know how to identify and when to report ADRs and whether they are reporting ADRs to the relevant authorities. In addition, the study seeks to determine their attitudes towards identification and reporting of ADRs and finally, to make recommendations for interventions to improve the knowledge, attitudes and practices of pharmacists in relation to the identification and reporting of ADRs. The study was designed as an observational, cross-sectional, analytical study. This design was used since it offered a cost-effective way of gathering information from many people in a relatively short period. Study Population and sampling: The study took place in Harare, Zimbabwe, where over 44% of the country’s private community pharmacies are located. A census approach was used as little is known about the subject locally. A self-administered questionnaire was designed to establish the socio-demographics of the respondents, their knowledge on ADR reporting and their attitudes and practices regarding ADR reporting. The questionnaires were distributed via electronic mail and at a continuing professional development session to a combined total of 129 community pharmacists. Data were analysed using Statistical Package for the Social Sciences (SPSS) version 16 and Microsoft Excel 2007. The respondents displayed poor knowledge of ADR reporting and hence there is under-reporting of ADRs. Factors such as post-graduate training and years of experience post- graduation have no bearing on the knowledge possessed by the respondents regarding ADR reporting. Although the respondents showed an appreciation of the importance of ADR reporting, there are barriers such as lack of knowledge and fear of legal liability that prevent pharmacists from reporting ADRs. Discussion: Lack of knowledge is the main barrier to reporting of ADRs by community pharmacist in Zimbabwe. To address this gap, interventions such as education for community pharmacists are required for both undergraduate pharmacist students and qualified pharmacists. There is a low level of knowledge and poor attitudes and practices amongst Zimbabwean pharmacists with respect to ADR reporting. Multi-sectoral interventions are required to overcome the barriers that community pharmacists encounter… Advisors/Committee Members: Gray, Andrew Lofts. (advisor).

Subjects/Keywords: Theses - Pharmaceutical Sciences.; Adverse drug reactions.; Community pharmacy (Harare)

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APA (6^th Edition):

Mafundikwa, T. C. (2017). Knowledge, attitudes and practices of community pharmacists in Harare regarding the reporting of adverse drug reactions. (Thesis). University of KwaZulu-Natal. Retrieved from http://hdl.handle.net/10413/15746

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mafundikwa, Tafadzwa Christine. “Knowledge, attitudes and practices of community pharmacists in Harare regarding the reporting of adverse drug reactions.” 2017. Thesis, University of KwaZulu-Natal. Accessed April 18, 2021. http://hdl.handle.net/10413/15746.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mafundikwa, Tafadzwa Christine. “Knowledge, attitudes and practices of community pharmacists in Harare regarding the reporting of adverse drug reactions.” 2017. Web. 18 Apr 2021.

Vancouver:

Mafundikwa TC. Knowledge, attitudes and practices of community pharmacists in Harare regarding the reporting of adverse drug reactions. [Internet] [Thesis]. University of KwaZulu-Natal; 2017. [cited 2021 Apr 18]. Available from: http://hdl.handle.net/10413/15746.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mafundikwa TC. Knowledge, attitudes and practices of community pharmacists in Harare regarding the reporting of adverse drug reactions. [Thesis]. University of KwaZulu-Natal; 2017. Available from: http://hdl.handle.net/10413/15746

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Dundee

15. Siddiqui, Moneeza Kalhan. Genetic factors in statin intolerance.

Degree: PhD, 2016, University of Dundee

URL: https://discovery.dundee.ac.uk/en/studentTheses/5852fdf4-5737-4c23-a391-f0bc4e627ebb ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.716218

► Background: There are approximately 12 million statin users in the United Kingdom. Reports of statin intolerance occurs between 7 and 29% of users, manifesting as… (more)

▼ Background: There are approximately 12 million statin users in the United Kingdom. Reports of statin intolerance occurs between 7 and 29% of users, manifesting as muscle ache, fatigue or more seriously, muscle breakdown leading to myopathy. Creatine phosphokinase (CK) levels are used as a biomarker of statin-induced muscle damage. Non-adherence or discontinuation of therapy is a common result of intolerance and can result in negative cardiovascular disease-related outcomes. Aim: This thesis attempts to identify trends in record-linked medical data in a Scottish Caucasian cohort (GoDARTS) that best represent statin intolerance in order to study associated genetic factors. Methods: Prescribing trends such as switching or discontinuation of statin therapy were examined, and thresholds created to select true cases of intolerance. Information on CK levels was gathered from medical records and appropriate test results were utilized. Genotypic data was gathered for the variants and genetic regions of interest using a variety of methods including chip-based genotyping followed by imputation, TAQMAN genotyping, and exome sequencing. Subsequently hypothesis-based association analyses were conducted, including linear and logistic regressions, followed by meta-analyses, regional GWAS followed by a regional meta –analysis. Results: The phenotypes of statin intolerance were validated both internally and externally. Previously reported missense variants in LILRB5 (Asp247Gly) and CKM (Glu83Gly) were replicated and shown to be associated with CK levels irrespective of statin usage in the GoDARTS cohort and the clinical trial setting (JUPITER). Further, the CKM variant was also associated with inducibility of CK at times of tissue injury. The Asp247 genotype in LILRB5 was associated with increased risk of statin intolerance, and was replicated in associations with non-compliance to statin therapy and the development of myalgia in the JUPITER trial. The association with myalgia showed a stratified effect based on therapy (statin or placebo), with those on placebo showing the genotype effect. Further, the variant was also associated with increased risk of statin-induced myositis, cases of which had been clinically adjudicated and exome sequenced for the PREDICTION-ADR consortium. Further exploration of the LILR gene region showed an association with variants in LILRB2 (His20Arg and Val235Met) which were in strong LD with each other but were not in linkage with the variant in LILRB5. Stratified analysis revealed that the risk for carriers of the LILRB2 variants was increased depending on the genotype carried at the LILRB5 variant. Conclusions: This study characterises novel genetic factors associated with statin intolerance impacting adherence. The findings point to the immunomodulatory effects of statins. The results suggest that true statin-induced myalgia and non-specific myalgia are distinct, with a possible role for the immune system in their development. The findings encourage further investigation into the immune-physiology of…

Subjects/Keywords: 615.7; Pharmacogenetics; Adverse drug reactions; Population genetics; Statins

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APA (6^th Edition):

Siddiqui, M. K. (2016). Genetic factors in statin intolerance. (Doctoral Dissertation). University of Dundee. Retrieved from https://discovery.dundee.ac.uk/en/studentTheses/5852fdf4-5737-4c23-a391-f0bc4e627ebb ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.716218

Chicago Manual of Style (16^th Edition):

Siddiqui, Moneeza Kalhan. “Genetic factors in statin intolerance.” 2016. Doctoral Dissertation, University of Dundee. Accessed April 18, 2021. https://discovery.dundee.ac.uk/en/studentTheses/5852fdf4-5737-4c23-a391-f0bc4e627ebb ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.716218.

MLA Handbook (7^th Edition):

Siddiqui, Moneeza Kalhan. “Genetic factors in statin intolerance.” 2016. Web. 18 Apr 2021.

Vancouver:

Siddiqui MK. Genetic factors in statin intolerance. [Internet] [Doctoral dissertation]. University of Dundee; 2016. [cited 2021 Apr 18]. Available from: https://discovery.dundee.ac.uk/en/studentTheses/5852fdf4-5737-4c23-a391-f0bc4e627ebb ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.716218.

Council of Science Editors:

Siddiqui MK. Genetic factors in statin intolerance. [Doctoral Dissertation]. University of Dundee; 2016. Available from: https://discovery.dundee.ac.uk/en/studentTheses/5852fdf4-5737-4c23-a391-f0bc4e627ebb ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.716218

University of the Western Cape

16. Nambatya, Winnie. Monitoring lipid and haematological abnormalities in paediatric patients on antiretroviral therapy at a Community Health Centre in the Cape Metropole .

Degree: 2014, University of the Western Cape

URL: http://hdl.handle.net/11394/4328

► South Africa faces a huge Human Immunodeficiency Virus (HIV) burden with more than 400,000 children currently on antiretroviral therapy (ART). Studies on lipid and haematological… (more)

▼ South Africa faces a huge Human Immunodeficiency Virus (HIV) burden with more than 400,000 children currently on antiretroviral therapy (ART). Studies on lipid and haematological profile changes in paediatrics are of particular interest since these children are exposed to ART in the course of a developmentally significant period and will possibly have longer collective exposure to ART. As such, monitoring for adverse effects, including lipid and haematological abnormalities, is essential for curtailing morbidity and mortality rates of children on ART. There is a dearth of studies assessing lipid and haematological abnormalities in the South African paediatric population on ART where genetic differences, co-morbidities, malnutrition and use of traditional medicines, all influence the safety profile of a drug. The goal of this study was twofold: Firstly to identify a suitable parameter for assessing lipid and haematological abnormalities in paediatrics on Antiretroviral (ARV) treatment using available secondary data and secondly, to assess prescriber adherence to routine monitoring tests in the ART guidelines. This study was a retrospective review of secondary data obtained from 168 patient clinical records at a Community Health Centre in the Cape Metropole, Western Cape and corresponding laboratory data from the National Health Laboratory Service (NHLS) database. Appropriate cholesterol, triglyceride, haemoglobin and neutrophil test results were compared against the standard reference ranges/values. The Chi-Squared test identified associations between total cholesterol (TC) /triglycerides and haemoglobin (Hb)/neutrophil and other independent variables. Evaluation of health care provider adherence to routine monitoring tests was assessed against relevant national ARV management guidelines. There was a paucity of baseline data for all laboratory markers and infrequent follow-up tests were ordered by healthcare providers. This precluded the measurement of changing lipid and haematological levels and an alternative parameter, viz., the highest available laboratory test value for each marker per patient, was assessed against reference values/ranges. Only nine out of the 36 (25%) patients on an AZT regimen had any Hb or neutrophil laboratory tests performed and 23 and two out of 97 (24% and 2%) patients, respectively, on a protease inhibitor (PI) had a TC and triglyceride laboratory test performed. Anaemia was detected in 45.5 % of children below five years of age, in 21.7% between ages of six and 11 and in 65.5 % between 12 and 14 years of age. Neutropenia was detected in 25.6% of children below five years of age and in 50% aged between six and 11. Hypercholesterolemia was found in 13.1% of patients. The only statistically statistical associations were found between the TC and CD4 count in children aged six to 14 years (χ2=5.000; p=0.025) and between neutrophil counts and viral load in children aged six to 14 years (χ2=6.4532; p=0.0240). A significant association was also found between Hb levels and viral load (χ2=7.000;… Advisors/Committee Members: Ward, Kim L (advisor), Mugabo, Pierre (advisor).

Subjects/Keywords: Antiretroviral drugs; Adverse drug reactions; Dyslipidemias; Antiretroviral therapy

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APA (6^th Edition):

Nambatya, W. (2014). Monitoring lipid and haematological abnormalities in paediatric patients on antiretroviral therapy at a Community Health Centre in the Cape Metropole . (Thesis). University of the Western Cape. Retrieved from http://hdl.handle.net/11394/4328

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Nambatya, Winnie. “Monitoring lipid and haematological abnormalities in paediatric patients on antiretroviral therapy at a Community Health Centre in the Cape Metropole .” 2014. Thesis, University of the Western Cape. Accessed April 18, 2021. http://hdl.handle.net/11394/4328.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Nambatya, Winnie. “Monitoring lipid and haematological abnormalities in paediatric patients on antiretroviral therapy at a Community Health Centre in the Cape Metropole .” 2014. Web. 18 Apr 2021.

Vancouver:

Nambatya W. Monitoring lipid and haematological abnormalities in paediatric patients on antiretroviral therapy at a Community Health Centre in the Cape Metropole . [Internet] [Thesis]. University of the Western Cape; 2014. [cited 2021 Apr 18]. Available from: http://hdl.handle.net/11394/4328.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Nambatya W. Monitoring lipid and haematological abnormalities in paediatric patients on antiretroviral therapy at a Community Health Centre in the Cape Metropole . [Thesis]. University of the Western Cape; 2014. Available from: http://hdl.handle.net/11394/4328

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of the Western Cape

17. Williams, Charles. Perceptions and experiences of reporting of adverse drug reactions by public sector pharmacists in a rural district in the Western Cape .

Degree: 2016, University of the Western Cape

URL: http://hdl.handle.net/11394/4915

► Background: Adverse Drug Reactions (ADRs) contribute to potentially expensive hospital admissions and are regarded as a major public health priority. ADRs in South Africa are… (more)

▼ Background: Adverse Drug Reactions (ADRs) contribute to potentially expensive hospital admissions and are regarded as a major public health priority. ADRs in South Africa are mainly detected by a spontaneous reporting system but it is plagued by under-reporting. Previous records indicated under-reporting of ADRs in the Cape Winelands District amongst healthcare workers. Pharmacists, in particular, did not report ADRs compared to other healthcare cadres whilst they are generally considered to be the custodians of medicines. Study Aim: This study aimed to explore and describe the perceptions and experiences of rural public sector pharmacists’ reporting of ADRs and to understand why pharmacists in this rural health district under-reported ADRs. Study Design: A qualitative study design was appropriate for this research question as the researcher wanted to gain an in-depth understanding of human behavior related to the phenomena of under-reporting. Study Population and Sampling: The primary study population consisted of 24 public sector pharmacists in the Cape Winelands District. A purposive sampling strategy enabled the selection of 16 pharmacists ranging in gender, age, experience and rank. Eight pharmacists were supervisor pharmacists while the rest were production pharmacists, including a community service pharmacist and an intern pharmacist. Supervisor pharmacists are more involved with managerial tasks and the attendance of meetings compared to production pharmacists that focus on patient care and dispensing of medication. Two key informants involved in the Western Cape Pharmacovigilance System were included in the study. One key stakeholder was a policy specialist pharmacist working at Directorate: Pharmacy Services and primarily involved with the Provincial Pharmacy and Therapeutics Committee. The other key policy stakeholder, at the time of the study, was the manager of the Medicines Information Centre which forms part of the University of Cape Town’s (UCT) Pharmacology Division. Both were highly experienced pharmacists familiar with the pharmacovigilance system. Data Collection: In-depth interviews were conducted using a semi-structured interview guide consisting of open- ended questions. The semi-structured interview guide was tested on a participant outside the primary study population. Interviews were conducted in English and Afrikaans. Interviews were tape-recorded and the interviewers made field notes to supplement the data recorded. Two researchers with experience in qualitative data collection, briefed by the investigator, interviewed the pharmacists who worked in the district and the investigator interviewed the two key stakeholders. Data Analysis: The tape recordings were translated, where applicable, and all were transcribed verbatim by the investigator. The transcribed recordings were analyzed by the investigator by assigning codes to material on an Excel spreadsheet. This approach enabled the identification of themes which aided the understanding of the research phenomena. Ethics: Ethical approval… Advisors/Committee Members: Bradley, Hazel (advisor).

Subjects/Keywords: Pharmacists; Rural District; Adverse drug reactions; Pharmacovigilance; South Africa

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Williams, C. (2016). Perceptions and experiences of reporting of adverse drug reactions by public sector pharmacists in a rural district in the Western Cape . (Thesis). University of the Western Cape. Retrieved from http://hdl.handle.net/11394/4915

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Williams, Charles. “Perceptions and experiences of reporting of adverse drug reactions by public sector pharmacists in a rural district in the Western Cape .” 2016. Thesis, University of the Western Cape. Accessed April 18, 2021. http://hdl.handle.net/11394/4915.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Williams, Charles. “Perceptions and experiences of reporting of adverse drug reactions by public sector pharmacists in a rural district in the Western Cape .” 2016. Web. 18 Apr 2021.

Vancouver:

Williams C. Perceptions and experiences of reporting of adverse drug reactions by public sector pharmacists in a rural district in the Western Cape . [Internet] [Thesis]. University of the Western Cape; 2016. [cited 2021 Apr 18]. Available from: http://hdl.handle.net/11394/4915.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Williams C. Perceptions and experiences of reporting of adverse drug reactions by public sector pharmacists in a rural district in the Western Cape . [Thesis]. University of the Western Cape; 2016. Available from: http://hdl.handle.net/11394/4915

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Arizona

18. Jimenez-Canet, Mark. Coordinated Regulation Of Hepatic And Renal Membrane Transporters In Experimental Nonalcoholic Steatohepatitis .

Degree: 2014, University of Arizona

URL: http://hdl.handle.net/10150/333487

► Inter-individual variability in drug response is a significant clinical concern and may lead to the development of adverse drug reactions, which are currently a top-ten… (more)

▼ Inter-individual variability in drug response is a significant clinical concern and may lead to the development of adverse drug reactions, which are currently a top-ten cause of death in the United States. Recently, the manifestation of disease, which may alter normal physiological function, has gained increased attention for its role as a contributing factor in the development of inter-individual responses to drugs. One such disease, known as nonalcoholic fatty liver disease (NAFLD), is the most common chronic liver disease in Western society and represents a spectrum of clinical morbidities that range from the usually benign simple fatty liver to the more advanced nonalcoholic steatohepatitis (NASH). Prior investigations have identified liver-specific alterations in xenobiotic transporter and metabolizing enzymes in NASH, which lead to the functional disruption of drug disposition. To identify a useful model(s) that is representative of hepatic transporter expression profiles in humans with NASH, gene and protein expression profiles of liver membrane transporters were assayed across several commonly used experimental rodent models of the disease. NASH models that were representative of the human condition developed global, adaptive changes in transporter regulation in the liver, which was not present in models that failed to recapitulate human profiles. Specifically, decreased expression of hepatic uptake transporters was coupled with an induction of efflux transporters, which may serve as a hepatoprotective response by limiting hepatic exposure to potentially harmful substances during times of tissue stress. To link a possible molecular mechanism for these hepatic adaptations in NASH, the role of the oxidative stress-activated transcription factor, Nrf2, was investigated. A functional Nrf2 regulatory element was identified within the eighth intron of the human ABCC3 transporter gene, implicating Nrf2 activation in NASH as a contributor to the coordinated induction of hepatic efflux transporters in the disease. To further clarify the effects of NASH on renal membrane transporter regulation, a thorough analysis of gene and protein expression was conducted with the validated rodent models used previously. Following the manifestation of disease, a global induction of renal efflux was observed, suggesting a compensatory, coordinated response of membrane transporters in the kidney upon disease induction. The functional consequences of liver and kidney xenobiotic transporter dysregulation was shown to disrupt the disposition of the environmental toxicant, arsenic. Specifically, NASH results in increased excretion of arsenic into urine as well as altered hepatic and renal exposure. These findings are associated with hepatic and renal transporter dysregulation and demonstrate for the first time that NASH alters the disposition of environmental toxicants. In summary, these studies contribute novel findings that identify liver and kidney-specific adaptations in disease that may contribute to global alterations in xenobiotic… Advisors/Committee Members: Cherrington, Nathan J (advisor), Cherrington, Nathan J. (committeemember), Gandolfi, A. Jay (committeemember), Klimecki, Walter T. (committeemember), Vaillancourt, Richard R. (committeemember), Wright, Stephen H. (committeemember).

Subjects/Keywords: liver disease; membrane transporters; pharmacokinetics; Pharmacology & Toxicology; adverse drug reactions

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Jimenez-Canet, M. (2014). Coordinated Regulation Of Hepatic And Renal Membrane Transporters In Experimental Nonalcoholic Steatohepatitis . (Doctoral Dissertation). University of Arizona. Retrieved from http://hdl.handle.net/10150/333487

Chicago Manual of Style (16^th Edition):

Jimenez-Canet, Mark. “Coordinated Regulation Of Hepatic And Renal Membrane Transporters In Experimental Nonalcoholic Steatohepatitis .” 2014. Doctoral Dissertation, University of Arizona. Accessed April 18, 2021. http://hdl.handle.net/10150/333487.

MLA Handbook (7^th Edition):

Jimenez-Canet, Mark. “Coordinated Regulation Of Hepatic And Renal Membrane Transporters In Experimental Nonalcoholic Steatohepatitis .” 2014. Web. 18 Apr 2021.

Vancouver:

Jimenez-Canet M. Coordinated Regulation Of Hepatic And Renal Membrane Transporters In Experimental Nonalcoholic Steatohepatitis . [Internet] [Doctoral dissertation]. University of Arizona; 2014. [cited 2021 Apr 18]. Available from: http://hdl.handle.net/10150/333487.

Council of Science Editors:

Jimenez-Canet M. Coordinated Regulation Of Hepatic And Renal Membrane Transporters In Experimental Nonalcoholic Steatohepatitis . [Doctoral Dissertation]. University of Arizona; 2014. Available from: http://hdl.handle.net/10150/333487

19. van Strien, AM. Adverse drug reactions of antipsychotics in frail older patients.

Degree: 2017, NARCIS

URL: https://research.vumc.nl/en/publications/bc99f818-6d77-49d0-9a9d-805f63ca1db8 ; urn:nbn:nl:ui:31-bc99f818-6d77-49d0-9a9d-805f63ca1db8 ; bc99f818-6d77-49d0-9a9d-805f63ca1db8 ; 1871/55338 ; urn:nbn:nl:ui:31-bc99f818-6d77-49d0-9a9d-805f63ca1db8 ; https://research.vumc.nl/en/publications/bc99f818-6d77-49d0-9a9d-805f63ca1db8

Subjects/Keywords: antipsychotics; adverse drug reactions; elderly

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

van Strien, A. (2017). Adverse drug reactions of antipsychotics in frail older patients. (Doctoral Dissertation). NARCIS. Retrieved from https://research.vumc.nl/en/publications/bc99f818-6d77-49d0-9a9d-805f63ca1db8 ; urn:nbn:nl:ui:31-bc99f818-6d77-49d0-9a9d-805f63ca1db8 ; bc99f818-6d77-49d0-9a9d-805f63ca1db8 ; 1871/55338 ; urn:nbn:nl:ui:31-bc99f818-6d77-49d0-9a9d-805f63ca1db8 ; https://research.vumc.nl/en/publications/bc99f818-6d77-49d0-9a9d-805f63ca1db8

Chicago Manual of Style (16^th Edition):

van Strien, AM. “Adverse drug reactions of antipsychotics in frail older patients.” 2017. Doctoral Dissertation, NARCIS. Accessed April 18, 2021. https://research.vumc.nl/en/publications/bc99f818-6d77-49d0-9a9d-805f63ca1db8 ; urn:nbn:nl:ui:31-bc99f818-6d77-49d0-9a9d-805f63ca1db8 ; bc99f818-6d77-49d0-9a9d-805f63ca1db8 ; 1871/55338 ; urn:nbn:nl:ui:31-bc99f818-6d77-49d0-9a9d-805f63ca1db8 ; https://research.vumc.nl/en/publications/bc99f818-6d77-49d0-9a9d-805f63ca1db8.

MLA Handbook (7^th Edition):

van Strien, AM. “Adverse drug reactions of antipsychotics in frail older patients.” 2017. Web. 18 Apr 2021.

Vancouver:

van Strien A. Adverse drug reactions of antipsychotics in frail older patients. [Internet] [Doctoral dissertation]. NARCIS; 2017. [cited 2021 Apr 18]. Available from: https://research.vumc.nl/en/publications/bc99f818-6d77-49d0-9a9d-805f63ca1db8 ; urn:nbn:nl:ui:31-bc99f818-6d77-49d0-9a9d-805f63ca1db8 ; bc99f818-6d77-49d0-9a9d-805f63ca1db8 ; 1871/55338 ; urn:nbn:nl:ui:31-bc99f818-6d77-49d0-9a9d-805f63ca1db8 ; https://research.vumc.nl/en/publications/bc99f818-6d77-49d0-9a9d-805f63ca1db8.

Council of Science Editors:

van Strien A. Adverse drug reactions of antipsychotics in frail older patients. [Doctoral Dissertation]. NARCIS; 2017. Available from: https://research.vumc.nl/en/publications/bc99f818-6d77-49d0-9a9d-805f63ca1db8 ; urn:nbn:nl:ui:31-bc99f818-6d77-49d0-9a9d-805f63ca1db8 ; bc99f818-6d77-49d0-9a9d-805f63ca1db8 ; 1871/55338 ; urn:nbn:nl:ui:31-bc99f818-6d77-49d0-9a9d-805f63ca1db8 ; https://research.vumc.nl/en/publications/bc99f818-6d77-49d0-9a9d-805f63ca1db8

20. van Strien, A.M. Adverse drug reactions of antipsychotics in frail older patients.

Degree: 2017, NARCIS

URL: https://research.vu.nl/en/publications/fbc1a733-dc60-4361-ad53-24faf6890c77 ; urn:nbn:nl:ui:31-1871/55338 ; fbc1a733-dc60-4361-ad53-24faf6890c77 ; 1871/55338 ; urn:nbn:nl:ui:31-1871/55338 ; https://research.vu.nl/en/publications/fbc1a733-dc60-4361-ad53-24faf6890c77

Subjects/Keywords: antipsychotics; adverse drug reactions; elderly

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

van Strien, A. M. (2017). Adverse drug reactions of antipsychotics in frail older patients. (Doctoral Dissertation). NARCIS. Retrieved from https://research.vu.nl/en/publications/fbc1a733-dc60-4361-ad53-24faf6890c77 ; urn:nbn:nl:ui:31-1871/55338 ; fbc1a733-dc60-4361-ad53-24faf6890c77 ; 1871/55338 ; urn:nbn:nl:ui:31-1871/55338 ; https://research.vu.nl/en/publications/fbc1a733-dc60-4361-ad53-24faf6890c77

Chicago Manual of Style (16^th Edition):

van Strien, A M. “Adverse drug reactions of antipsychotics in frail older patients.” 2017. Doctoral Dissertation, NARCIS. Accessed April 18, 2021. https://research.vu.nl/en/publications/fbc1a733-dc60-4361-ad53-24faf6890c77 ; urn:nbn:nl:ui:31-1871/55338 ; fbc1a733-dc60-4361-ad53-24faf6890c77 ; 1871/55338 ; urn:nbn:nl:ui:31-1871/55338 ; https://research.vu.nl/en/publications/fbc1a733-dc60-4361-ad53-24faf6890c77.

MLA Handbook (7^th Edition):

van Strien, A M. “Adverse drug reactions of antipsychotics in frail older patients.” 2017. Web. 18 Apr 2021.

Vancouver:

van Strien AM. Adverse drug reactions of antipsychotics in frail older patients. [Internet] [Doctoral dissertation]. NARCIS; 2017. [cited 2021 Apr 18]. Available from: https://research.vu.nl/en/publications/fbc1a733-dc60-4361-ad53-24faf6890c77 ; urn:nbn:nl:ui:31-1871/55338 ; fbc1a733-dc60-4361-ad53-24faf6890c77 ; 1871/55338 ; urn:nbn:nl:ui:31-1871/55338 ; https://research.vu.nl/en/publications/fbc1a733-dc60-4361-ad53-24faf6890c77.

Council of Science Editors:

van Strien AM. Adverse drug reactions of antipsychotics in frail older patients. [Doctoral Dissertation]. NARCIS; 2017. Available from: https://research.vu.nl/en/publications/fbc1a733-dc60-4361-ad53-24faf6890c77 ; urn:nbn:nl:ui:31-1871/55338 ; fbc1a733-dc60-4361-ad53-24faf6890c77 ; 1871/55338 ; urn:nbn:nl:ui:31-1871/55338 ; https://research.vu.nl/en/publications/fbc1a733-dc60-4361-ad53-24faf6890c77

University of Melbourne

21. Trubiano, Jason Anthony. Antibiotic allergy testing and its impact on antimicrobial stewardship.

Degree: 2017, University of Melbourne

URL: http://hdl.handle.net/11343/210539

► The impact of antibiotic allergy and its implications for antimicrobial stewardship (AMS) in Australia has been previously ill defined. Whilst removal of patient-reported antibiotic allergy… (more)

▼ The impact of antibiotic allergy and its implications for antimicrobial stewardship (AMS) in Australia has been previously ill defined. Whilst removal of patient-reported antibiotic allergy (so-called antibiotic allergy labels [AAL]) via allergist de-labelling has been reported, the demand for, feasibility and impacts of incorporating antibiotic allergy testing (AAT) into antimicrobial stewardship (AMS) programs (AAT-AMS) has not been investigated. Further, the utility of clinical (in vivo) and laboratory (ex vivo/in vitro) diagnostics in AAT to aid appropriate antibiotic prescribing in patients with the most severe antibiotic allergy phenotypes has also remained unclear. The objectives of this thesis were to examine the (a) burden, (b) impacts, (c) severity, (d) diagnostic approaches and (e) AMS implications of antibiotic allergy in Australia. Burden, impacts and severity of antibiotic allergy in Australia Employing prospective single-centre point prevalence surveys, cohort studies and the National Antibiotic Prescribing Survey (NAPS) this work identified that 18% of patients admitted to an Australian hospital had a recorded AAL, up to 25% in immunocompromised hosts and the elderly. Of the reported AALs, almost 20% reflected ‘false’ or non-immune-mediated antibiotic allergies. The identified AALs had significant implications for AMS, impacting the pattern of antimicrobial use, with lower β-lactam use (AAL versus no antibiotic allergy label [NAAL], odds ratio [OR] 0.47, 95% confidence interval [CI] 0.43–0.50, p<0.001), and higher quinolone (OR 2.07, 95% CI 1.83–2.34, p<0.0001), glycopeptide (OR 1.59, 95% CI 1.38–1.83, p<0.0001) and carbapenem use (OR 1.74, 95% CI 1.43–2.13, p<0.0001) in those with an AAL, most predominant in immunocompromised hosts. Multiple antibiotics were implicated in 48% of severe [T-cell mediated] cutaneous adverse drug reactions (SCAR), impacting drug causality assessments, increased mortality (21%) and post-discharge allergy labelling. Clinicians in Australia, New Zealand and North America were engaged to incorporate AAT into AMS programs to reduce the burden of AALs and aid antibiotic prescribing. However, a significant hurdle identified was that 41% of those surveyed did not have AAT available to them and many would not refer severe T-cell mediated ADR for testing. Another identified barrier to AAT-AMS implementation was that stakeholders demonstrated poor antibiotic allergy knowledge and tended to significantly overestimate the rates of β-lactam cross-reactivity. Diagnostic approaches to severe antibiotic allergy In patients with SCAR, a subgroup of severe T-cell mediated ADRs, the combination of ex vivo (IFN-γ release ELISpot) and traditional in vivo (skin/patch testing) diagnostics identified the culprit antibiotic in 79% of patients, with no systemic adverse events noted. The sensitivity and specificity IFN-γ release ELISpot in isolation was 52% and 100%, respectively. Combined in vivo and ex vivo testing showed independent and complementary promise in aiding narrow…

Subjects/Keywords: antimicrobial stewardship; antibiotic allergy; antibiotic resistance; drug allergy; infectious diseases; severe cutaneous adverse drug reactions

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Trubiano, J. A. (2017). Antibiotic allergy testing and its impact on antimicrobial stewardship. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/210539

Chicago Manual of Style (16^th Edition):

Trubiano, Jason Anthony. “Antibiotic allergy testing and its impact on antimicrobial stewardship.” 2017. Doctoral Dissertation, University of Melbourne. Accessed April 18, 2021. http://hdl.handle.net/11343/210539.

MLA Handbook (7^th Edition):

Trubiano, Jason Anthony. “Antibiotic allergy testing and its impact on antimicrobial stewardship.” 2017. Web. 18 Apr 2021.

Vancouver:

Trubiano JA. Antibiotic allergy testing and its impact on antimicrobial stewardship. [Internet] [Doctoral dissertation]. University of Melbourne; 2017. [cited 2021 Apr 18]. Available from: http://hdl.handle.net/11343/210539.

Council of Science Editors:

Trubiano JA. Antibiotic allergy testing and its impact on antimicrobial stewardship. [Doctoral Dissertation]. University of Melbourne; 2017. Available from: http://hdl.handle.net/11343/210539

University of Ghana

22. Kuuridong, A.S. Adverse Drug Reaction Reporting Among Health Professionals in the Lawra Municipal Hospital of the Upper West Region .

Degree: 2019, University of Ghana

URL: http://ugspace.ug.edu.gh/handle/123456789/33568

► Background; Medicines have the potential to cause Adverse Drug Reactions (ADR) and therefore the need for health professionals to detect and spontaneously report to the… (more)

Subjects/Keywords: Drug Reaction; Adverse Drug Reactions (ADR); Lawra Municipal Hospital; Upper West Region

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kuuridong, A. S. (2019). Adverse Drug Reaction Reporting Among Health Professionals in the Lawra Municipal Hospital of the Upper West Region . (Masters Thesis). University of Ghana. Retrieved from http://ugspace.ug.edu.gh/handle/123456789/33568

Chicago Manual of Style (16^th Edition):

Kuuridong, A S. “Adverse Drug Reaction Reporting Among Health Professionals in the Lawra Municipal Hospital of the Upper West Region .” 2019. Masters Thesis, University of Ghana. Accessed April 18, 2021. http://ugspace.ug.edu.gh/handle/123456789/33568.

MLA Handbook (7^th Edition):

Kuuridong, A S. “Adverse Drug Reaction Reporting Among Health Professionals in the Lawra Municipal Hospital of the Upper West Region .” 2019. Web. 18 Apr 2021.

Vancouver:

Kuuridong AS. Adverse Drug Reaction Reporting Among Health Professionals in the Lawra Municipal Hospital of the Upper West Region . [Internet] [Masters thesis]. University of Ghana; 2019. [cited 2021 Apr 18]. Available from: http://ugspace.ug.edu.gh/handle/123456789/33568.

Council of Science Editors:

Kuuridong AS. Adverse Drug Reaction Reporting Among Health Professionals in the Lawra Municipal Hospital of the Upper West Region . [Masters Thesis]. University of Ghana; 2019. Available from: http://ugspace.ug.edu.gh/handle/123456789/33568

University of Toronto

23. Pelcowitz, Matthew Jason. A Meta-analytic Review of Selected Adverse Drug Events (ADEs) of Long-term Prescription Opioids for Chronic Non-cancer Pain (CNCP).

Degree: 2016, University of Toronto

URL: http://hdl.handle.net/1807/75848

►

Background: Opioids are considered one of the most effective analgesics. However, knowledge on opioid adverse drug events (ADEs) is limited and the current state of… (more)

Subjects/Keywords: Adverse Drug Events; Adverse Drug Reactions; Chronic Non-Cancer Pain; Meta-analysis; Opioids; Prescription medication; 0564

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APA (6^th Edition):

Pelcowitz, M. J. (2016). A Meta-analytic Review of Selected Adverse Drug Events (ADEs) of Long-term Prescription Opioids for Chronic Non-cancer Pain (CNCP). (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/75848

Chicago Manual of Style (16^th Edition):

Pelcowitz, Matthew Jason. “A Meta-analytic Review of Selected Adverse Drug Events (ADEs) of Long-term Prescription Opioids for Chronic Non-cancer Pain (CNCP).” 2016. Masters Thesis, University of Toronto. Accessed April 18, 2021. http://hdl.handle.net/1807/75848.

MLA Handbook (7^th Edition):

Pelcowitz, Matthew Jason. “A Meta-analytic Review of Selected Adverse Drug Events (ADEs) of Long-term Prescription Opioids for Chronic Non-cancer Pain (CNCP).” 2016. Web. 18 Apr 2021.

Vancouver:

Pelcowitz MJ. A Meta-analytic Review of Selected Adverse Drug Events (ADEs) of Long-term Prescription Opioids for Chronic Non-cancer Pain (CNCP). [Internet] [Masters thesis]. University of Toronto; 2016. [cited 2021 Apr 18]. Available from: http://hdl.handle.net/1807/75848.

Council of Science Editors:

Pelcowitz MJ. A Meta-analytic Review of Selected Adverse Drug Events (ADEs) of Long-term Prescription Opioids for Chronic Non-cancer Pain (CNCP). [Masters Thesis]. University of Toronto; 2016. Available from: http://hdl.handle.net/1807/75848

University of KwaZulu-Natal

24. Moyo, Nokuthemba Sibusiso. Evaluating adverse drug reactions associated with antibiotic use in a public sector hospital.

Degree: 2016, University of KwaZulu-Natal

URL: https://researchspace.ukzn.ac.za/handle/10413/18088

► Background and Aim Antibiotics are one of the most troublesome classes of drugs contributing to adverse drug reactions. These adverse drug reactions are generally under… (more)

Subjects/Keywords: Pharmacovigilance.; Antibiotics.; Adverse drug reactions.; Drugs side effects.; Adverse drug reaction reports - South Africa.; Antibiotics side effects.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Moyo, N. S. (2016). Evaluating adverse drug reactions associated with antibiotic use in a public sector hospital. (Thesis). University of KwaZulu-Natal. Retrieved from https://researchspace.ukzn.ac.za/handle/10413/18088

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Moyo, Nokuthemba Sibusiso. “Evaluating adverse drug reactions associated with antibiotic use in a public sector hospital.” 2016. Thesis, University of KwaZulu-Natal. Accessed April 18, 2021. https://researchspace.ukzn.ac.za/handle/10413/18088.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Moyo, Nokuthemba Sibusiso. “Evaluating adverse drug reactions associated with antibiotic use in a public sector hospital.” 2016. Web. 18 Apr 2021.

Vancouver:

Moyo NS. Evaluating adverse drug reactions associated with antibiotic use in a public sector hospital. [Internet] [Thesis]. University of KwaZulu-Natal; 2016. [cited 2021 Apr 18]. Available from: https://researchspace.ukzn.ac.za/handle/10413/18088.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Moyo NS. Evaluating adverse drug reactions associated with antibiotic use in a public sector hospital. [Thesis]. University of KwaZulu-Natal; 2016. Available from: https://researchspace.ukzn.ac.za/handle/10413/18088

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade Estadual de Campinas

25. Souza, Cinthia Madeira de, 1987-. Incidência, caracterização e acompanhamento da resolução de eventos adversos aos medicamentos em pacientes admitidos em emergência pediátrica.

Degree: Faculdade de Ciências Médicas; Programa de Pós-Graduação em Ciências Médicas, 2016, Universidade Estadual de Campinas

URL: SOUZA, Cinthia Madeira de. Incidência, caracterização e acompanhamento da resolução de eventos adversos aos medicamentos em pacientes admitidos em emergência pediátrica. 2016. 1 recurso online (113 p.). Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas, Campinas, SP. Disponível em: <http://www.repositorio.unicamp.br/handle/REPOSIP/321094>. Acesso em: 31 ago. 2018. ; http://repositorio.unicamp.br/jspui/handle/REPOSIP/321094

►

Orientador: Patricia Moriel

Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas

Made available in DSpace on 2018-08-31T13:06:51Z (GMT). No. of bitstreams: 1… (more)

▼

Orientador: Patricia Moriel

Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas

Made available in DSpace on 2018-08-31T13:06:51Z (GMT). No. of bitstreams: 1 Souza_CinthiaMadeirade_M.pdf: 3685923 bytes, checksum: c5d4cad411b220b03fa8bfacef492fb9 (MD5) Previous issue date: 2016

Resumo: Crianças fazem parte de um importante segmento da população, entretanto elas são excluídas dos ensaios clínicos. Como consequência, estão mais vulneráveis a apresentar eventos adversos a medicamentos (EAMs) pois os possíveis prejuízos não foram estudados. Este estudo foi conduzido para determinar a taxa e caracterizar os EAMs em pacientes pediátricos e também para explorar a efetividade do acompanhamento farmacoterapêutico. Foi conduzido um estudo clínico e prospectivo em uma Unidade de Emergência Pediátrica, durante o período de fevereiro de 2014 a fevereiro de 2015. Os EAMs foram classificados em cinco categorias: Reação Adversa a Medicamento (RAM), Inefetividade Terapêutica, Erros de Medicação, Interação Medicamentosa, Uso off-label, Queixas Técnicas e Intoxicações. Sessenta e nove pacientes (4,5%) foram admitidos na UER com 81 EAMs. Os mais prevalentes foram srro de medicação (30; 40,5%), RAM (21; 25,9%) e ineficácia terapêutica (21; 25,9%). No que se refere a preventabilidade, 64,9% foram previsíveis. O farmacêutico clínico foi capaz de contribuir no plano de cuidados para resolver os EAMs em 84,7% dos pacientes pediátricos, através de 158 intervenções farmacêuticas, sendo esta redução estatisticamente significativa (p<0,0001). Este estudo mostra uma incidência alarmante de EAMs, com a maioria previsível. O acompanhamento farmacoterapêutico foi efetivo para reduzir os prejuízos causados pelos EAMs

Children are an important segment of the population; however they are often excluded from clinical trials. As a consequence they may be more vulnerable to adverse drug events (ADEs) because potential harms have not been studied. This study was conducted to determine the rate and to characterize ADEs in a cohort of pediatric patients and to explore the effectiveness of clinical pharmacist interventions. A clinical and prospective study was conducted in a Pediatric Emergency Room (ER), during February 2014 to February 2015. The ADEs were categorized into eight categories: Adverse Drug Reaction (ADR), Medication Error, Off-label Use, Drug Intoxication, Abusive Use of Drugs, Drug Interaction, Technical Defects and Ineffective Therapeutics (IT). The pharmaceutical follow-up was based on the Pharmacists Workup, from Minnesota, and included quantifying that Drug Related Problems (DRPs) and making pharmaceutical interventions (PI). Sixty-nine (4.5%) patients were admitted in the ER with 81 ADEs. The most prevalent were Medication Error (30; 40.5%), ADR (21, 25.9%) and IT (21, 25.9%). Regarding the preventability, 64.9% of them were deemed preventable. The clinical pharmacist was able to contribute to the care to resolve the ADEs in 84.7% of the children by making 158 pharmaceutical interventions.…

Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS, Moriel, Patricia, 1972-, Kawano, Daniel Fábio, Costa, José Luiz da.

Subjects/Keywords: Farmacovigilância; Atenção farmacêutica; Pediatria; Toxicidade de drogas; Pharmacovigilance; Pharmaceutical care; Pediatrics; Drug-related side effects and adverse reactions; Adverse drug events

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Souza, Cinthia Madeira de, 1. (2016). Incidência, caracterização e acompanhamento da resolução de eventos adversos aos medicamentos em pacientes admitidos em emergência pediátrica. (Masters Thesis). Universidade Estadual de Campinas. Retrieved from SOUZA, Cinthia Madeira de. Incidência, caracterização e acompanhamento da resolução de eventos adversos aos medicamentos em pacientes admitidos em emergência pediátrica. 2016. 1 recurso online (113 p.). Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas, Campinas, SP. Disponível em: <http://www.repositorio.unicamp.br/handle/REPOSIP/321094>. Acesso em: 31 ago. 2018. ; http://repositorio.unicamp.br/jspui/handle/REPOSIP/321094

Chicago Manual of Style (16^th Edition):

Souza, Cinthia Madeira de, 1987-. “Incidência, caracterização e acompanhamento da resolução de eventos adversos aos medicamentos em pacientes admitidos em emergência pediátrica.” 2016. Masters Thesis, Universidade Estadual de Campinas. Accessed April 18, 2021. SOUZA, Cinthia Madeira de. Incidência, caracterização e acompanhamento da resolução de eventos adversos aos medicamentos em pacientes admitidos em emergência pediátrica. 2016. 1 recurso online (113 p.). Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas, Campinas, SP. Disponível em: <http://www.repositorio.unicamp.br/handle/REPOSIP/321094>. Acesso em: 31 ago. 2018. ; http://repositorio.unicamp.br/jspui/handle/REPOSIP/321094.

MLA Handbook (7^th Edition):

Souza, Cinthia Madeira de, 1987-. “Incidência, caracterização e acompanhamento da resolução de eventos adversos aos medicamentos em pacientes admitidos em emergência pediátrica.” 2016. Web. 18 Apr 2021.

Vancouver:

Souza, Cinthia Madeira de 1. Incidência, caracterização e acompanhamento da resolução de eventos adversos aos medicamentos em pacientes admitidos em emergência pediátrica. [Internet] [Masters thesis]. Universidade Estadual de Campinas; 2016. [cited 2021 Apr 18]. Available from: SOUZA, Cinthia Madeira de. Incidência, caracterização e acompanhamento da resolução de eventos adversos aos medicamentos em pacientes admitidos em emergência pediátrica. 2016. 1 recurso online (113 p.). Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas, Campinas, SP. Disponível em: <http://www.repositorio.unicamp.br/handle/REPOSIP/321094>. Acesso em: 31 ago. 2018. ; http://repositorio.unicamp.br/jspui/handle/REPOSIP/321094.

Council of Science Editors:

Souza, Cinthia Madeira de 1. Incidência, caracterização e acompanhamento da resolução de eventos adversos aos medicamentos em pacientes admitidos em emergência pediátrica. [Masters Thesis]. Universidade Estadual de Campinas; 2016. Available from: SOUZA, Cinthia Madeira de. Incidência, caracterização e acompanhamento da resolução de eventos adversos aos medicamentos em pacientes admitidos em emergência pediátrica. 2016. 1 recurso online (113 p.). Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas, Campinas, SP. Disponível em: <http://www.repositorio.unicamp.br/handle/REPOSIP/321094>. Acesso em: 31 ago. 2018. ; http://repositorio.unicamp.br/jspui/handle/REPOSIP/321094

26. Sindhu, M S. A Data Mining Approach for the Identification of Adverse Drug Events (ADE) resulting from Drug-Drug Interactions (DDI) to improve pharmacovigilance.

Degree: Computer Applications, 2013, Cochin University of Science and Technology

URL: http://dyuthi.cusat.ac.in/purl/4098

►

In the current study, epidemiology study is done by means of literature survey in groups identified to be at higher potential for DDIs as well… (more)

Subjects/Keywords: Adverse Drug Reactions; Drug-Drug Interactions; DDIs in pharmacovigilance; Methods of Achieving pharmacovigilance; FAERS Database Schema; Data Pre-processing

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sindhu, M. S. (2013). A Data Mining Approach for the Identification of Adverse Drug Events (ADE) resulting from Drug-Drug Interactions (DDI) to improve pharmacovigilance. (Thesis). Cochin University of Science and Technology. Retrieved from http://dyuthi.cusat.ac.in/purl/4098

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sindhu, M S. “A Data Mining Approach for the Identification of Adverse Drug Events (ADE) resulting from Drug-Drug Interactions (DDI) to improve pharmacovigilance.” 2013. Thesis, Cochin University of Science and Technology. Accessed April 18, 2021. http://dyuthi.cusat.ac.in/purl/4098.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sindhu, M S. “A Data Mining Approach for the Identification of Adverse Drug Events (ADE) resulting from Drug-Drug Interactions (DDI) to improve pharmacovigilance.” 2013. Web. 18 Apr 2021.

Vancouver:

Sindhu MS. A Data Mining Approach for the Identification of Adverse Drug Events (ADE) resulting from Drug-Drug Interactions (DDI) to improve pharmacovigilance. [Internet] [Thesis]. Cochin University of Science and Technology; 2013. [cited 2021 Apr 18]. Available from: http://dyuthi.cusat.ac.in/purl/4098.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sindhu MS. A Data Mining Approach for the Identification of Adverse Drug Events (ADE) resulting from Drug-Drug Interactions (DDI) to improve pharmacovigilance. [Thesis]. Cochin University of Science and Technology; 2013. Available from: http://dyuthi.cusat.ac.in/purl/4098

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

27. Lin, Hsiu-ying. Identifying Potential Adverse Drug Events from Tweets.

Degree: Master, Information Management, 2017, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0721117-172944

► ADRs will cause or prolong hospital admission and result in disability or death. Due to the various limitations of clinical trials, only the most common… (more)

Subjects/Keywords: Adverse drug reactions; Social media; Text mining; Supervised learning; Pharmacovigilance; Side effect

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lin, H. (2017). Identifying Potential Adverse Drug Events from Tweets. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0721117-172944

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lin, Hsiu-ying. “Identifying Potential Adverse Drug Events from Tweets.” 2017. Thesis, NSYSU. Accessed April 18, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0721117-172944.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lin, Hsiu-ying. “Identifying Potential Adverse Drug Events from Tweets.” 2017. Web. 18 Apr 2021.

Vancouver:

Lin H. Identifying Potential Adverse Drug Events from Tweets. [Internet] [Thesis]. NSYSU; 2017. [cited 2021 Apr 18]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0721117-172944.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lin H. Identifying Potential Adverse Drug Events from Tweets. [Thesis]. NSYSU; 2017. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0721117-172944

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Tasmania

28. Bezabhe, WM. Antiretroviral adherence and treatment outcomes among adult Ethiopian patients.

Degree: 2016, University of Tasmania

URL: https://eprints.utas.edu.au/23414/1/Bezabhe_whole_thesis.pdf

► The scale-up of antiretroviral therapy (ART) services has been one of the best achievements witnessed in the health sector in Ethiopia over the past decade.… (more)

▼ The scale-up of antiretroviral therapy (ART) services has been one of the best achievements witnessed in the health sector in Ethiopia over the past decade. A total of 339,043 adults had received treatment for Human Immunodeficiency Virus (HIV)/Acquired Immunodeficiency Syndrome (AIDS) in Ethiopia as of 2014, and this number is expected to increase over the coming years. Achievement of optimal medication adherence is becoming the greatest challenge in the management of HIV/AIDS. Patients with suboptimal adherence are at high risk of progression to AIDS, emergence of resistant viral strains, limited future treatment options, and higher treatment costs. Data on barriers to, and facilitators of, adherence in Ethiopian HIV-positive patients taking ART remains inconsistent and incomplete. The available cross-sectional studies are limited in that they have only assessed limited variables at a single point in time and qualitative studies have not yet explored factors associated with medication adherence at the individual level. While one prospective study has investigated adherence to ART in Ethiopia, it was only conducted for 3 months and also did not focus on treatment-naïve patients. The objectives of the body of work contained in this thesis were to fill these gaps using a mixed-methods approach that include both prospective quantitative and qualitative studies to establish the levels of medication adherence and identify a wide range of factors that influence medication adherence. We also assessed the incidence of adverse drug reactions (ADRs) and associated risk factors in Ethiopian patients with HIV/AIDS initiated on ART. The main study was conducted in two hospitals in Northwest Ethiopia: Gondar University and Felege-Hiwot Hospitals. It began with a prospective study in which 246 adult HIV-infected patients initiated on ART were followed from the time of initiation to 12 months of therapy. Patients had appointments every month for 6 months and every 3 months thereafter in ART clinics; research pharmacists collected data in line with patients’ appointment schedules in the ART clinics. In a subsequent study, semi-structured interviews were conducted with 24 patients, of whom 11 had been lost to follow-up and were non-persistent with ART. In addition, focus group discussions were performed with 15 ART nurses and 19 case managers. Questionnaires and interview guides were developed through a systematic procedure to ensure reliability, validity, and cultural appropriateness. Of 172 who completed follow-up in the prospective study, 130 (75.6%) had ≥95% adherence at 12 months. In the multivariate analyses, a higher baseline body mass index (BMI) (Odds Ratio (OR), 1.2; 95% CI 1.0, 1.4) and use of reminder devices ( OR, 9.1; 95% CI 2.0, 41.6) were positively associated with adherence, while a higher HIV symptom and ADR distress score was an independent negative predictor of adherence (OR, 0.90; 95% CI 0.9, 1.0). Clusters of differentiated 4 (CD4) count increase was significantly higher in the adherent patients compared to…

Subjects/Keywords: Antiretroviral therapy; medication adherence; treatment outcomes; HIV/AIDS; adverse drug reactions; Ethiopia

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bezabhe, W. (2016). Antiretroviral adherence and treatment outcomes among adult Ethiopian patients. (Thesis). University of Tasmania. Retrieved from https://eprints.utas.edu.au/23414/1/Bezabhe_whole_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bezabhe, WM. “Antiretroviral adherence and treatment outcomes among adult Ethiopian patients.” 2016. Thesis, University of Tasmania. Accessed April 18, 2021. https://eprints.utas.edu.au/23414/1/Bezabhe_whole_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bezabhe, WM. “Antiretroviral adherence and treatment outcomes among adult Ethiopian patients.” 2016. Web. 18 Apr 2021.

Vancouver:

Bezabhe W. Antiretroviral adherence and treatment outcomes among adult Ethiopian patients. [Internet] [Thesis]. University of Tasmania; 2016. [cited 2021 Apr 18]. Available from: https://eprints.utas.edu.au/23414/1/Bezabhe_whole_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bezabhe W. Antiretroviral adherence and treatment outcomes among adult Ethiopian patients. [Thesis]. University of Tasmania; 2016. Available from: https://eprints.utas.edu.au/23414/1/Bezabhe_whole_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Liberty University

29. Wilkins-Copeland, Samantha Bonita. Preventing Polypharmacy Amongst the Elderly in an Acute Care Setting Through the Integration of the Deprescribing Tools START, STOPP, and Beers Criteria.

Degree: 2020, Liberty University

URL: https://digitalcommons.liberty.edu/doctoral/2624

► A significant percentage of medications prescribed in the United States are prescribed to elderly adults, which is due to the increase in chronic illness as… (more)

Subjects/Keywords: Polypharmacy; Elderly/geriatrics; START/STOPP Criteria; Beers Criteria; Deprescribing; Adverse Drug Reactions; Medical Sciences; Nursing

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wilkins-Copeland, S. B. (2020). Preventing Polypharmacy Amongst the Elderly in an Acute Care Setting Through the Integration of the Deprescribing Tools START, STOPP, and Beers Criteria. (Doctoral Dissertation). Liberty University. Retrieved from https://digitalcommons.liberty.edu/doctoral/2624

Chicago Manual of Style (16^th Edition):

Wilkins-Copeland, Samantha Bonita. “Preventing Polypharmacy Amongst the Elderly in an Acute Care Setting Through the Integration of the Deprescribing Tools START, STOPP, and Beers Criteria.” 2020. Doctoral Dissertation, Liberty University. Accessed April 18, 2021. https://digitalcommons.liberty.edu/doctoral/2624.

MLA Handbook (7^th Edition):

Wilkins-Copeland, Samantha Bonita. “Preventing Polypharmacy Amongst the Elderly in an Acute Care Setting Through the Integration of the Deprescribing Tools START, STOPP, and Beers Criteria.” 2020. Web. 18 Apr 2021.

Vancouver:

Wilkins-Copeland SB. Preventing Polypharmacy Amongst the Elderly in an Acute Care Setting Through the Integration of the Deprescribing Tools START, STOPP, and Beers Criteria. [Internet] [Doctoral dissertation]. Liberty University; 2020. [cited 2021 Apr 18]. Available from: https://digitalcommons.liberty.edu/doctoral/2624.

Council of Science Editors:

Wilkins-Copeland SB. Preventing Polypharmacy Amongst the Elderly in an Acute Care Setting Through the Integration of the Deprescribing Tools START, STOPP, and Beers Criteria. [Doctoral Dissertation]. Liberty University; 2020. Available from: https://digitalcommons.liberty.edu/doctoral/2624

30. Dias, Carlos André Ribeiro. Possible emodepside toxicosis in a Collie with MDR1 gene mutation.

Degree: 2014, RCAAP

URL: https://www.rcaap.pt/detail.jsp?id=oai:comum.rcaap.pt:10400.26/16628

►

The multi-drug resistance gene 1 (MDR1) is responsible for encoding an efflux transport protein designated P-glycoprotein (P-gp). The P-gp is expressed in various tissues such… (more)

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The multi-drug resistance gene 1 (MDR1) is responsible for encoding an efflux transport protein designated P-glycoprotein (P-gp). The P-gp is expressed in various tissues such as the capillary endothelial cells of the brain, renal tubular cells, intestinal cells, skin, among others. It is also present in some types of neoplastic cells, where it is often overexpressed. It is a glycosylated transmembrane protein that transports several amphipathic and hydrophobic molecules, such as toxins and xenobiotics, including drugs commonly used in veterinary practice. A mutation in MDR1 gene is frequent in some dog breeds, and encodes the synthesis of a non-functional P-gp. The absence of P-gp in the blood-brain barrier may originate the accumulation of its substrates in the central nervous system, leading to neurotoxicity. Currently, a wide variety of molecules are known to be substrates of P-gp. This mutation has been classically associated with ivermectin neurotoxicity in dogs of Collie breeds. However, this mutation has been described in several other dog breeds, mainly herding breeds, and associated with toxicity of other drugs and toxins. This paper reports a clinical case of a strong suspicion of neurotoxicity associated with an overdose of emodepside in a Collie dog carrier of an homozygous mutation in the MDR1 gene. Although the neurotoxicity associated with the overdose of emodepside is recognized by the European Medicines Agency, this is, to our best knowledge, the first clinical report of a possible emodepside toxicosis. Considering the relevance of P-gp function in drug metabolism, it is of paramount importance to screen the MDR1 gene mutation, especially in dogs breeds where this mutation is frequent, so that safe drugs are used in the treatment of these animals

O gene da multirresistência aos fármacos 1 (MDR1) é responsável por codificar uma proteína transportadora, designada glicoproteína-P (P-gp). A P-gp encontra-se presente em diferentes tecidos, tais como, células endoteliais dos vasos cerebrais, células dos túbulos renais, intestino, pele, entre outros. Está também presente em alguns tipos de células neoplásicas, onde se encontra frequentemente sobre-expressa. É uma proteína transmembranar glicosada, que tem a função de transportar para o exterior das células diversos compostos anfipáticos e hidrofóbicos tais como toxinas e xenobióticos, entre os quais vários fármacos usados correntemente na prática veterinária. Em algumas raças de cães é frequente a existência de uma mutação do gene MDR1, que origina a síntese de uma P-gp não funcional. A ausência da P-gp na barreira hematoencefálica permite a acumulação dos seus substratos no sistema nervoso central, originando neurotoxicidade. Atualmente são reconhecidas várias moléculas como substratos da P-gp. Esta mutação é classicamente associada à neurotoxicidade por ivermectina em cães das raças Collie e seus cruzamentos. No entanto, esta mutação está também descrita em diversas outras raças de cães, maioritariamente de pastoreio, e tem sido associada a toxicidade…

Advisors/Committee Members: Francisco, Anabela Maduro de Almeida, Vilhena, Hugo Corte-Real.

Subjects/Keywords: Collie; Emodepside; Adverse Drug Reactions; MDR 1 gene mutation; ABCB 1 gene; P Glycoprotein

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dias, C. A. R. (2014). Possible emodepside toxicosis in a Collie with MDR1 gene mutation. (Thesis). RCAAP. Retrieved from https://www.rcaap.pt/detail.jsp?id=oai:comum.rcaap.pt:10400.26/16628

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Dias, Carlos André Ribeiro. “Possible emodepside toxicosis in a Collie with MDR1 gene mutation.” 2014. Thesis, RCAAP. Accessed April 18, 2021. https://www.rcaap.pt/detail.jsp?id=oai:comum.rcaap.pt:10400.26/16628.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Dias, Carlos André Ribeiro. “Possible emodepside toxicosis in a Collie with MDR1 gene mutation.” 2014. Web. 18 Apr 2021.

Vancouver:

Dias CAR. Possible emodepside toxicosis in a Collie with MDR1 gene mutation. [Internet] [Thesis]. RCAAP; 2014. [cited 2021 Apr 18]. Available from: https://www.rcaap.pt/detail.jsp?id=oai:comum.rcaap.pt:10400.26/16628.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Dias CAR. Possible emodepside toxicosis in a Collie with MDR1 gene mutation. [Thesis]. RCAAP; 2014. Available from: https://www.rcaap.pt/detail.jsp?id=oai:comum.rcaap.pt:10400.26/16628

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Open Access Theses and Dissertations