subject:(acute lymphoblastic leukemia)

University of Southern California

1. Shojaee, Seyedmehdi. Induction of hypersignaling as a therapeutic approach for treatment of BCR-ABL1 positive Acute Lymphoblastic Leukemia (ALL) cells.

Degree: PhD, Genetic, Molecular and Cellular Biology, 2013, University of Southern California

URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/231158/rec/3470

► Current therapy approaches for tyrosine kinase driven leukemia including Ph⁺ ALL and CML are almost entirely focused on the development of more potent tyrosine kinase… (more)

▼ Current therapy approaches for tyrosine kinase driven leukemia including Ph⁺ ALL and CML are almost entirely focused on the development of more potent tyrosine kinase inhibitors (TKI). The ultimate goal in this approach is to reduce the oncogenic signaling below a minimum threshold that is required for the survival of leukemia cells. Despite the successful results obtained so far, this approach has its own drawbacks. Unfortunately, TKI treatment is not very effective in Ph⁺ ALL patients. Furthermore, in CML patients it can lead to the appearance of resistant tumors that are not sensitive to therapy anymore. Therefore, new strategies for killing the Ph⁺ leukemia independent of kinase inhibition are necessary. ❧ Hypersignaling has been known as an unfavorable condition for the survival of cells, and induction of hypersignaling may result in stalled proliferation or cellular senescence. However, its implication as a therapeutic mean has not been well-characterized. One strategy for induction of hypersignaling is to suppress the inhibitory regulators of signaling pathways. Therefore, we hypothesized that inhibition of negative feedback regulators or inhibitory phosphatases in Ph⁺ kinase leukemia could raise the signaling level and induce cell cycle arrest or senescence in transformed cells. Importantly, cells lacking high oncogenic kinase activity should be insensitive to such inhibition of negative feedback signaling. ❧ In chapter two of this thesis, we focused on the mitogen-activated protein kinase (MAPK) pathway. By the analysis of gene expression changes and evaluation of protein levels, we found that DUSP6 and SPRY2, two negative feedback regulators of the MAPK pathway, are highly expressed in human B cell lineage Ph⁺ ALL, while they are not expressed in B cell progenitor cells. Interestingly, in contrast to BCR-ABL1 kinase driven leukemia, non kinase-driven B cell Non-Hodgkin-Lymphoma (B-NHL) lack expression of these genes. To study the function of DUSP6 and SPRY2 in a genetic mouse model of Ph⁺ like leukemia, we transduced bone marrow pre-B cells from DUSP6-/-, SPRY2fl/fl mice and respective wildtype controls with retroviral BCR-ABL1. Defects in either of these two negative feedback mediators caused profound signaling imbalances in BCR-ABL1 leukemia cells and resulted in drastic negative consequences for the cells. For instance, Dusp6-deficient leukemia cells rapidly underwent cellular senescence and were less capable of colony formation in semisolid culture. In addition, Lack of Dusp6 and Spry2 dramatically increased cellular reactive oxygen species (ROS). Furthermore, inducible Cre-mediated deletion of Spry2 in leukemia cells resulted in rapid cell death. ❧ To test whether negative feedback signaling molecules represent a potential target for pharmacological inhibition in the treatment of kinase driven leukemia, we tested the DUSP6 small molecule inhibitor 2-benzylidene-3-(cyclohexylamino)-1-Indanone hydrochloride (BCI). BCI induced massive accumulation of ROS and subsequent cell death in a panel of… Advisors/Committee Members: Muschen, Markus (Committee Chair), Lieber, Michael R. (Committee Member), Heisterkamp, Eleanora C. (Committee Member), Jung, Jae U. (Committee Member), Kim, Yong-Mi (Committee Member).

Subjects/Keywords: hypersignaling; Acute Lymphoblastic Leukemia

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APA (6^th Edition):

Shojaee, S. (2013). Induction of hypersignaling as a therapeutic approach for treatment of BCR-ABL1 positive Acute Lymphoblastic Leukemia (ALL) cells. (Doctoral Dissertation). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/231158/rec/3470

Chicago Manual of Style (16^th Edition):

Shojaee, Seyedmehdi. “Induction of hypersignaling as a therapeutic approach for treatment of BCR-ABL1 positive Acute Lymphoblastic Leukemia (ALL) cells.” 2013. Doctoral Dissertation, University of Southern California. Accessed February 28, 2021. http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/231158/rec/3470.

MLA Handbook (7^th Edition):

Shojaee, Seyedmehdi. “Induction of hypersignaling as a therapeutic approach for treatment of BCR-ABL1 positive Acute Lymphoblastic Leukemia (ALL) cells.” 2013. Web. 28 Feb 2021.

Vancouver:

Shojaee S. Induction of hypersignaling as a therapeutic approach for treatment of BCR-ABL1 positive Acute Lymphoblastic Leukemia (ALL) cells. [Internet] [Doctoral dissertation]. University of Southern California; 2013. [cited 2021 Feb 28]. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/231158/rec/3470.

Council of Science Editors:

Shojaee S. Induction of hypersignaling as a therapeutic approach for treatment of BCR-ABL1 positive Acute Lymphoblastic Leukemia (ALL) cells. [Doctoral Dissertation]. University of Southern California; 2013. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/231158/rec/3470

University of Southern California

2. Orgel, Etan. Nutrition and body composition in pediatric acute lymphoblastic leukemia.

Degree: MS, Clinical and Biomedical Investigations, 2012, University of Southern California

URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/667904/rec/4496

► Intensification of treatment for Acute Lymphoblastic Leukemia (ALL) has improved survival but has also led to large increases in treatment-related toxicity (TRT). Weight and body… (more)

▼ Intensification of treatment for Acute Lymphoblastic Leukemia (ALL) has improved survival but has also led to large increases in treatment-related toxicity (TRT). Weight and body composition are well-recognized mediators of chronic disease whose impact in childhood cancer is still being determined. Previous studies and pilot data have demonstrated that children with ALL undergo significant changes in body composition during therapy that may have a significant effect on TRT and outcome. ❧ We therefore undertook a two-part investigation into body composition and its effect on TRT in childhood ALL. Children's Oncology Group (COG) CCG-1961 was a large cooperative group clinical trial in high-risk ALL. We conducted a secondary analysis of the study that demonstrated either weight extreme, severely underweight or obese, was associated with increased TRT. Outcome as measured by event-free survival (EFS) was worse in both weight extremes but this did not reach statistical significance on multivariate analysis. The second half of our investigation is ongoing and explores a common complication of ALL therapy. Poor bone health affects approximately one in four children during treatment and also has the potential for long-term sequalae and reduced quality of survival. As Vitamin D insufficiency is prevalent in this population and known to be a key mediator of bone health, we therefore designed a prospective, randomized, double-blinded, placebo-controlled interventional clinical trial of Vitamin D supplementation in the context of body composition. This will also provide an in-depth description of bone metabolism during treatment for ALL that will help identify other targets for future intervention. ❧ These two studies represent only the surface of the likely impact of weight and body composition on TRT in the treatment of childhood ALL and other cancers and further research is required to continue to characterize their effect on different morbidities. Advisors/Committee Members: Mittelman, Steven (Committee Chair), Freyer, David (Committee Member), Seeger, Robert C. (Committee Member).

Subjects/Keywords: oncology; acute lymphoblastic leukemia; nutrition

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Orgel, E. (2012). Nutrition and body composition in pediatric acute lymphoblastic leukemia. (Masters Thesis). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/667904/rec/4496

Chicago Manual of Style (16^th Edition):

Orgel, Etan. “Nutrition and body composition in pediatric acute lymphoblastic leukemia.” 2012. Masters Thesis, University of Southern California. Accessed February 28, 2021. http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/667904/rec/4496.

MLA Handbook (7^th Edition):

Orgel, Etan. “Nutrition and body composition in pediatric acute lymphoblastic leukemia.” 2012. Web. 28 Feb 2021.

Vancouver:

Orgel E. Nutrition and body composition in pediatric acute lymphoblastic leukemia. [Internet] [Masters thesis]. University of Southern California; 2012. [cited 2021 Feb 28]. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/667904/rec/4496.

Council of Science Editors:

Orgel E. Nutrition and body composition in pediatric acute lymphoblastic leukemia. [Masters Thesis]. University of Southern California; 2012. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/667904/rec/4496

University of Lund

3. Safavi, Setareh. Molecular Genetic Characterization of Acute Lymphoblastic Leukemia with a Poor Prognosis.

Degree: 2015, University of Lund

URL: https://lup.lub.lu.se/record/8045790 ; https://portal.research.lu.se/ws/files/3465041/8045811.docx

► Acute lymphoblastic leukemia (ALL) affects individuals at all ages, with peak incidences in children <4 years and adults >50 years. ALL is broadly categorized into… (more)

▼ Acute lymphoblastic leukemia (ALL) affects individuals at all ages, with peak incidences in children <4 years and adults >50 years. ALL is broadly categorized into B-cell precursor (BCP) and T-cell ALL with specific clinical features associated with outcome. In contrast to pediatric ALL, which has a favorable prognosis, adult ALL is associated with a much poorer outcome with less than 40% overall survival rates, decreasing with higher age. The presence of specific acquired genetic abnormalities is important for diagnosis, prognostication, and treatment stratification. ALL can be further categorized into subgroups defined by structural or ploidy abnormalities. One such subgroup, hypodiploid ALL (<46 chromosomes) is seen in 5-8% of all cases, and associated with a very dismal prognosis. It can be further subdivided into two distinct genetic and clinical subgroups, namely near-haploidy (24-31 chromosomes) and low hypodiploidy (32-39 chromosomes), and, comprising cases with a more heterogenous background, high hypodiploidy (40-43 chromosomes) and cases with 44 and 45 chromosomes. Near-haploid and low hypodiploid ALL are very rare, comprising less than 1% of BCP ALL, with overall survival rates of <30%. The general aim of my PhD project has been to characterize ALL patients with a poor prognosis, including adult ALL (article I) and hypodiploid ALL (article II-IV). To investigate the genetic landscape of adult ALL, we performed SNP array analysis on 126 ALL cases. Characteristic deletions seen in pediatric ALL were detected, furthermore, comparison of diagnostic and relapse clonal relationship showed evolution from an ancestral clone in the majority of cases, highlighting similarities in childhood and adult disease. In addition, the analysis revealed several recurrent cryptic genetic events not previously implicated with adult ALL, including the BCAT1, BTLA, NR3C1, PIK3AP1 and SERP2 genes. In articles II-IV the genetic and epigenetic background of hypodiploid ALL was further investigated using SNP array analysis, exome and RNA sequencing, methylation array analysis and FISH analysis. Characteristic chromosomal patterns were confirmed and subtype specific alterations targeting IKZF3, NF1, FLT3 and TP53 were identified near-haploid and low hypodiploid respectively. Furthermore, due to the specific pattern of CDKN2A deletions in one case, we could conclude that chromosomal loss was the primary event with further microdeletions occurring after the near-haploidization. Combining SNP array and FISH analysis, a sublconal pattern was detected in three cases harboring >79 chromosomes, showing a possible hypodiploid origin due to the extensive loss of heterozygosity identified in such cases. That all three cases harbored TP53 mutations emphasized similarities to low hypodiploid ALL. In conclusion, screening for specific genetic abnormalities routinely in the clinic may improve prognostication and treatment stratification in cases with a poor prognosis.

Subjects/Keywords: Clinical Laboratory Medicine; Acute lymphoblastic leukemia; hypodiploidy; adult acute lymphoblastic leukemia

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Safavi, S. (2015). Molecular Genetic Characterization of Acute Lymphoblastic Leukemia with a Poor Prognosis. (Doctoral Dissertation). University of Lund. Retrieved from https://lup.lub.lu.se/record/8045790 ; https://portal.research.lu.se/ws/files/3465041/8045811.docx

Chicago Manual of Style (16^th Edition):

Safavi, Setareh. “Molecular Genetic Characterization of Acute Lymphoblastic Leukemia with a Poor Prognosis.” 2015. Doctoral Dissertation, University of Lund. Accessed February 28, 2021. https://lup.lub.lu.se/record/8045790 ; https://portal.research.lu.se/ws/files/3465041/8045811.docx.

MLA Handbook (7^th Edition):

Safavi, Setareh. “Molecular Genetic Characterization of Acute Lymphoblastic Leukemia with a Poor Prognosis.” 2015. Web. 28 Feb 2021.

Vancouver:

Safavi S. Molecular Genetic Characterization of Acute Lymphoblastic Leukemia with a Poor Prognosis. [Internet] [Doctoral dissertation]. University of Lund; 2015. [cited 2021 Feb 28]. Available from: https://lup.lub.lu.se/record/8045790 ; https://portal.research.lu.se/ws/files/3465041/8045811.docx.

Council of Science Editors:

Safavi S. Molecular Genetic Characterization of Acute Lymphoblastic Leukemia with a Poor Prognosis. [Doctoral Dissertation]. University of Lund; 2015. Available from: https://lup.lub.lu.se/record/8045790 ; https://portal.research.lu.se/ws/files/3465041/8045811.docx

4. Papadopoulou, Anna. Μοριακοί δείκτες διάγνωσης, εξέλιξης και θεραπευτικής αντιμετώπισης παιδιών με αιματολογικές κακοήθειες.

Degree: 2019, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)

URL: http://hdl.handle.net/10442/hedi/45552

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This report describes a newly-designed molecular method based on the high sensitive techniques Fragment analysis and Quantitative real-time PCR that is able to scan leukemic… (more)

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This report describes a newly-designed molecular method based on the high sensitive techniques Fragment analysis and Quantitative real-time PCR that is able to scan leukemic DNA at very low levels in the blood of patients with pediatric acute lymphoblastic leukemia. Our study presents tracks of leukemic burden at diagnosis and on days 8, 15, 33 when the commonly used markers Bone marrow infiltration and Minimal Residual Disease (MRD) reduce the value (day 8) and eliminate it (days 15 and 33) giving the impression that blasts disappear from patient’s organism. Cell-free leukemic DNA can also be scanned on these days and appears to follow the same procession and behavior as nuclear leukemic DNA although at significantly lower levels.The detection of blasts on days 15 and 33, when the number of white blood cells reduces significantly, is crucial for the progression and response to chemotherapy. The analysis of the methylation status of the promoter of Rassf6 gene reveals a methyl-CpG-domain that carries methylgroups the number of which differs between two major groups of patients. Those with favorable and those with unfavorable outcome. Therefore the detection of nuclear and cell-free leukemic DNA in blood circulation of patients with acute lymphoblastic leukemia using the hypermethylated promoter of Rassf6 gene adds prognostic value to minimal residual disease status and gives hope of potential marker in ALL to become as it follows the reduce of leukemic burden and the presence or absence of blasts in blood circulation during chemotherapy and for long time afterwards.

Στην παρούσα διατριβή μελετήθηκαν καρκινικά κύτταρα από δείγματα ασθενών με οξεία λεμφοβλαστική λευχαιμία παιδικού τύπου. Τα δείγματα ελήφθησαν την ημέρα 0 (πρωτοδιάγνωση) και τις ημέρες 8, 15 και 33 όταν οι ασθενείς υποβάλλονταν σε χημειοθεραπεία. Στις ημέρες αυτές μελετήθηκε το λευχαιμικό πυρηνικό DNA καθώς και το λευχαιμικό cell-free DNA και συγκεκριμένα μελετήθηκε ο υποκινητής του ογκοκατασταλτικού γονιδίου Rassf6 για τον οποίον σχεδιάστηκε ειδική μέθοδος στο Εργαστήριο Ιατρικής Γενετικής, που περιελάμβανε αρκετές τεχνικές (πέψη, fragment analysis, quantitative real-time PCR και Sanger sequencing). Τα αποτελέσματα της μεθόδου έδειξαν την παρουσία καρκινικού DNA και τις 4 ημέρες θεραπείας, εύρημα αξιοσημείωτο καθώς τις ημέρες 15 και 33 οι δείκτες διήθηση μυελού (bone marrow infiltration) και ελάχιστη υπολειμματική νόσος (MRD) μηδενίζονται. Η ποσοτική μέτρηση του λευχαιμικού φορτίου μας δίνει πολύ υψηλές τιμές στην πρωτοδιάγνωση (ημέρα 0) οι οποίες μειώνονται ραγδαίως τις ημέρες 8, 15 και 33 όταν δηλαδή οι ασθενείς υποβάλλονται σε χημειοθεραπεία, παρά το γεγονός ότι και την ημέρα 33, καθώς και τις προηγούμενες ημέρες ανιχνεύεται λευχαιμικό φορτίο το οποίο ποσοτικοποιείται. Τέλος η κατά βάση αλληλούχιση του υποκινητή του γονιδίου Rassf6 μας αποκάλυψε την παρουσία των χημικών ομάδων του μεθυλίου (CH3) ο αριθμός των οποίων διέφερε μεταξύ των ασθενών με θετική έκβαση και των ασθενών που κατέληξαν. Οι πρώτοι ασθενείς είχαν αρκετές μεθυλομάδες, εν…

Subjects/Keywords: Οξεία λεμφοβλαστική λευχαιμία; Acute lymphoblastic leukemia

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Papadopoulou, A. (2019). Μοριακοί δείκτες διάγνωσης, εξέλιξης και θεραπευτικής αντιμετώπισης παιδιών με αιματολογικές κακοήθειες. (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/45552

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Papadopoulou, Anna. “Μοριακοί δείκτες διάγνωσης, εξέλιξης και θεραπευτικής αντιμετώπισης παιδιών με αιματολογικές κακοήθειες.” 2019. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed February 28, 2021. http://hdl.handle.net/10442/hedi/45552.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Papadopoulou, Anna. “Μοριακοί δείκτες διάγνωσης, εξέλιξης και θεραπευτικής αντιμετώπισης παιδιών με αιματολογικές κακοήθειες.” 2019. Web. 28 Feb 2021.

Vancouver:

Papadopoulou A. Μοριακοί δείκτες διάγνωσης, εξέλιξης και θεραπευτικής αντιμετώπισης παιδιών με αιματολογικές κακοήθειες. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2019. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10442/hedi/45552.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Papadopoulou A. Μοριακοί δείκτες διάγνωσης, εξέλιξης και θεραπευτικής αντιμετώπισης παιδιών με αιματολογικές κακοήθειες. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2019. Available from: http://hdl.handle.net/10442/hedi/45552

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Southern California

5. Patel, Ravindra. Induction therapy in relapse adult acute lymphoblastic leukemia.

Degree: MS, Clinical and Biomedical Investigations, 2015, University of Southern California

URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/346168/rec/3472

► Background: Currently available chemotherapeutic treatment for relapse/refractory acute lymphoblastic leukemia (ALL) helps to achieve complete remission (CR) in only one third of the patients. The… (more)

▼ Background: Currently available chemotherapeutic treatment for relapse/refractory acute lymphoblastic leukemia (ALL) helps to achieve complete remission (CR) in only one third of the patients. The definitive treatment for ALL is allogeneic hematopoietic stem cell transplant (HSCT) which can be used only in patients who achieved complete remission with the chemotherapy. We did the study to explore possibilities for better survival by using other possible chemotherapeutic regimens in relapsed/refractory ALL patients. ❧ Methods: Patients with ALL who relapsed or were refractory to chemotherapy, age range of 17 to 55 years, Karnofsky performance status of > 50%, and adequate hepatic and renal function were eligible for the study. The primary objective of the study was to achieve higher CR rate after the two phases of induction therapy as compared to standard of care. Secondary objectives were to achieve longer LFS (Leukemia free survival), measure regimen toxicity and decrease number of days required for neutrophil count recovery after each cycle of induction as compared to current chemotherapy for relapsed/refractory ALL patients. In an effort to improve the CR rate in adults ALL cases, a modified regimen was derived from pediatric Berlin-Frankfurt-Muenster (BFM)-85 protocol, with addition of a continuous infusional phase II induction followed by consolidation with alternating monthly cycles. ❧ Results: In this study, we have included the outcome of 19 patients treated prospectively on the study, as well as a subsequent cohort of 31 patients treated off the study. Thirteen out of nineteen (68%) patients from the initial prospective study achieved CR, and the median overall survival of these 13 CR patients was 10.3 months. The median survival and LFS of all 19 patients were 5.6 and 4.3 months respectively. The regimen was well-tolerated and no grade 4 non-hematological toxicity was observed. Of the 31 patients treated off the study and analyzed retrospectively, 16 (52%) achieved CR. After including all 50 patients, 29 achieved CR (58%). ❧ Conclusion: The regimen used in this trial helps to achieve higher CR than the current chemotherapeutic regimen for relapse/refractory ALL and helps to use allogeneic-HSCT as a definitive treatment in these patients. Advisors/Committee Members: Pullarkat, Vinod (Committee Chair), Aldoss, Ibrahim (Committee Member), Azen, Stanley P. (Committee Member).

Subjects/Keywords: acute lymphoblastic leukemia; adult; relapse; reinduction

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Patel, R. (2015). Induction therapy in relapse adult acute lymphoblastic leukemia. (Masters Thesis). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/346168/rec/3472

Chicago Manual of Style (16^th Edition):

Patel, Ravindra. “Induction therapy in relapse adult acute lymphoblastic leukemia.” 2015. Masters Thesis, University of Southern California. Accessed February 28, 2021. http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/346168/rec/3472.

MLA Handbook (7^th Edition):

Patel, Ravindra. “Induction therapy in relapse adult acute lymphoblastic leukemia.” 2015. Web. 28 Feb 2021.

Vancouver:

Patel R. Induction therapy in relapse adult acute lymphoblastic leukemia. [Internet] [Masters thesis]. University of Southern California; 2015. [cited 2021 Feb 28]. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/346168/rec/3472.

Council of Science Editors:

Patel R. Induction therapy in relapse adult acute lymphoblastic leukemia. [Masters Thesis]. University of Southern California; 2015. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/346168/rec/3472

University of Hawaii – Manoa

6. Landier, Wendy Carolyn. Predictors of non-adherence to oral chemotherapy in children with acute lymphoblastic leukemia.

Degree: 2016, University of Hawaii – Manoa

URL: http://hdl.handle.net/10125/101920

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Ph.D. University of Hawaii at Manoa 2010.

Overall survival for pediatric patients with acute lymphoblastic leukemia (A.L.L.) treated with contemporary therapy now exceeds 85%; however,… (more)

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Ph.D. University of Hawaii at Manoa 2010.

Overall survival for pediatric patients with acute lymphoblastic leukemia (A.L.L.) treated with contemporary therapy now exceeds 85%; however, approximately 20% will experience relapse. Since A.L.L. is the most common malignancy in children, relapsed patients comprise a large proportion of the total number of children with cancer. The prognosis for long-term survival following relapse is generally poor; thus, relapsed A.L.L. is a significant contributor to cancer-related mortality in children. Poor adherence to oral medication is a substantial problem in contemporary health care and may contribute to unexplained relapses in children with A.L.L. Therapy for pediatric A.L.L. includes a prolonged "maintenance" phase that requires daily 6-mercaptopurine (6MP), a self-or parent/caregiver-administered oral chemotherapy agent given for approximately two years. 6MP has been shown to be a critical component of the curative regimen for A.L.L.; thus, children with A.L.L. who fail to adhere to oral 6MP chemotherapy as prescribed may be at increased risk of leukemia relapse. This study used extant questionnaire data from a cohort of children with A.L.L enrolled on a Children's Oncology Group study (AALL03N1) to determine the prevalence of self/parent-reported non-adherence to oral 6MP during the maintenance phase of A.L.L. therapy, and to identify sociodemographic and behavioral predictors of non-adherence to oral 6MP. Twenty-two percent of children in the cohort were non-adherent to oral chemotherapy, defined as missing more than one dose of 6MP for non-medical reasons over the 112-day observation period. The risk of non-adherence was significantly increased for those who failed to perceive the severity of the child's illness (Odds ratio [OR] 1.89, 95% Confidence Interval [CI] 1.00-3.55, P=0.049) or the benefits of treatment with oral 6MP (OR 1.78, 95%CI 1.07-2.94, P=0.025). Vulnerable subgroups included Hispanic ethnicity (OR 2.25, 95%CI 1.30-3.90, P=0.004) and older age (OR 1.07 per year, 95%CI 1.02-1.12, P=0.005). Study findings suggest that even occasional reports of missed 6MP doses may herald a significant adherence problem; that patients and their parents may need ongoing reminders regarding the subclinical and asymptomatic nature of leukemia in remission; and that frequent review with families regarding the purpose, function, and proper administration of oral 6MP is imperative.

Subjects/Keywords: childhood acute lymphoblastic leukemia; oral chemotherapy; adherence

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Landier, W. C. (2016). Predictors of non-adherence to oral chemotherapy in children with acute lymphoblastic leukemia. (Thesis). University of Hawaii – Manoa. Retrieved from http://hdl.handle.net/10125/101920

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Landier, Wendy Carolyn. “Predictors of non-adherence to oral chemotherapy in children with acute lymphoblastic leukemia.” 2016. Thesis, University of Hawaii – Manoa. Accessed February 28, 2021. http://hdl.handle.net/10125/101920.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Landier, Wendy Carolyn. “Predictors of non-adherence to oral chemotherapy in children with acute lymphoblastic leukemia.” 2016. Web. 28 Feb 2021.

Vancouver:

Landier WC. Predictors of non-adherence to oral chemotherapy in children with acute lymphoblastic leukemia. [Internet] [Thesis]. University of Hawaii – Manoa; 2016. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10125/101920.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Landier WC. Predictors of non-adherence to oral chemotherapy in children with acute lymphoblastic leukemia. [Thesis]. University of Hawaii – Manoa; 2016. Available from: http://hdl.handle.net/10125/101920

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

California State University – Northridge

7. Kolettis, Nomiki. Interplay of apoptosis and autophagy in acute lymphoblastic leukemia cells.

Degree: MS, Department of Biology, 2014, California State University – Northridge

URL: http://hdl.handle.net/10211.3/121331

► Apoptosis and Autophagy are two processes that play key roles in the death and survival of cells. Apoptosis is a cell death mechanism, where autophagy… (more)

Subjects/Keywords: acute lymphoblastic leukemia; Dissertations, Academic – CSUN – Biology.

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APA (6^th Edition):

Kolettis, N. (2014). Interplay of apoptosis and autophagy in acute lymphoblastic leukemia cells. (Masters Thesis). California State University – Northridge. Retrieved from http://hdl.handle.net/10211.3/121331

Chicago Manual of Style (16^th Edition):

Kolettis, Nomiki. “Interplay of apoptosis and autophagy in acute lymphoblastic leukemia cells.” 2014. Masters Thesis, California State University – Northridge. Accessed February 28, 2021. http://hdl.handle.net/10211.3/121331.

MLA Handbook (7^th Edition):

Kolettis, Nomiki. “Interplay of apoptosis and autophagy in acute lymphoblastic leukemia cells.” 2014. Web. 28 Feb 2021.

Vancouver:

Kolettis N. Interplay of apoptosis and autophagy in acute lymphoblastic leukemia cells. [Internet] [Masters thesis]. California State University – Northridge; 2014. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10211.3/121331.

Council of Science Editors:

Kolettis N. Interplay of apoptosis and autophagy in acute lymphoblastic leukemia cells. [Masters Thesis]. California State University – Northridge; 2014. Available from: http://hdl.handle.net/10211.3/121331

University of Arizona

8. Withycombe, Janice Squires. Early Weight Gain and Obesity in Childhood Acute Lymphoblastic Leukemia .

Degree: 2012, University of Arizona

URL: http://hdl.handle.net/10150/223340

► Obesity is a recognized problem for children treated for acute lymphoblastic leukemia (ALL) and is present in roughly one fourth of children by the end… (more)

▼ Obesity is a recognized problem for children treated for acute lymphoblastic leukemia (ALL) and is present in roughly one fourth of children by the end of therapy. Obesity may lead to immediate health threats, such as an increased risk for cancer relapse, or may cause future heath issues such as diabetes, metabolic syndrome, hypertension, additional cancers, depression or cardiovascular disease. The purpose of this study was to determine if weight gain during two individual cycles of therapy (Induction or Delayed Intensification Cycle 1) were predictive of obesity (defined as body mass index ≥ 95th percentile for age and gender) at the end of treatment. This study retrospectively examined height and weight data from 1,017 childhood leukemia patients treated on Children's Oncology Group (COG) protocol number 1961. This study included patients that had fully completed therapy on protocol 1961 and who were between the ages of 2-20 years. Percentiles and z-scores for age and gender specific body mass index (BMI) were calculated using the height and weight measurements obtained at the beginning of each cycle of chemotherapy. Univariate and multivariate logistic regression analyses were performed. BMI z-score at the beginning of therapy and difference in BMI z-score during Induction were significant predictors (p<0.0001) of BMI ≥ 95th percentile at the end of maintenance in both males and females. A one unit increase in the difference of BMI z-score during Induction resulted in a 3.03 odds ratio (OR) for obesity at the end of therapy for males (95% CI, 1.90 to 4.84) and a 4.15 OR for females (95% CI, 2.32 to 7.43). The change in BMI z-score during Delayed Intensification I was not found to be significant in relationship to obesity at the end of therapy. Weight gain during Induction consisted of ≥ 20% increase in weight for 3.9% of the study participants. Weight gain during Induction therapy of childhood ALL treatment may be useful in predicting patients at increased risk for obesity development during therapy. Early identification of these at risk patients can assist with interventions aimed at normalizing weight gain during therapy. Advisors/Committee Members: Moore, Ki (advisor), Faulkner, Melissa Spezia (committeemember), Merkle, Carrie (committeemember), Meza, Jane (committeemember), Ritter, Leslie (committeemember), Moore, Ki (committeemember).

Subjects/Keywords: Obesity; Nursing; Acute Lymphoblastic Leukemia; Childhood

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APA (6^th Edition):

Withycombe, J. S. (2012). Early Weight Gain and Obesity in Childhood Acute Lymphoblastic Leukemia . (Doctoral Dissertation). University of Arizona. Retrieved from http://hdl.handle.net/10150/223340

Chicago Manual of Style (16^th Edition):

Withycombe, Janice Squires. “Early Weight Gain and Obesity in Childhood Acute Lymphoblastic Leukemia .” 2012. Doctoral Dissertation, University of Arizona. Accessed February 28, 2021. http://hdl.handle.net/10150/223340.

MLA Handbook (7^th Edition):

Withycombe, Janice Squires. “Early Weight Gain and Obesity in Childhood Acute Lymphoblastic Leukemia .” 2012. Web. 28 Feb 2021.

Vancouver:

Withycombe JS. Early Weight Gain and Obesity in Childhood Acute Lymphoblastic Leukemia . [Internet] [Doctoral dissertation]. University of Arizona; 2012. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10150/223340.

Council of Science Editors:

Withycombe JS. Early Weight Gain and Obesity in Childhood Acute Lymphoblastic Leukemia . [Doctoral Dissertation]. University of Arizona; 2012. Available from: http://hdl.handle.net/10150/223340

University of New South Wales

9. Karsa, Mawar Murni. The significance of minimal residual disease at day 15 for predicting relapse in paediatric acute lymphoblastic leukemia.

Degree: Women's & Children's Health, 2011, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/51232 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:9908/SOURCE02?view=true

► Acute lymphoblastic leukemia (ALL) is the most common cancer in children. Current treatments result in continued complete remission in over 80% of patients, however up… (more)

▼ Acute lymphoblastic leukemia (ALL) is the most common cancer in children. Current treatments result in continued complete remission in over 80% of patients, however up to 20% relapse due to small numbers of surviving cells. Measurement of this minimal residual disease (MRD) at day 33 and day 79 is used in a current clinical trial, Australian and New Zealand Children’s Haematology/Oncology Group (ANZCHOG) Study 8 to decide patient treatment risk group. The level of MRD in a remission sample is defined as the amount of amplifiable gene rearrangement relative to the patient’s diagnosis sample. The hypothesis tested in this study was that MRD level at day 15 is also prognostic of patient outcome. MRD was measured by real-time quantitative PCR detection of immunoglobulin and T-cell receptor gene rearrangements in bone marrow DNA at day 15 from 211 paediatric patients at two hospitals and analysed according to EuroMRD guidelines.Day 15 MRD was highly prognostic of outcome (event-free-survival; EFS) at several thresholds especially at 1x10-2. About 61% of patients (28/46) who relapse have day 15 MRD greater than 1x10-2 and around 44% of patients with MRD above this threshold relapsed or had other events. Even after the exclusion of high risk patients, day 15 MRD was still prognostic of outcome (P=0.0001). It was also able to separate patients into three groups with different prognoses: patients with high MRD (≥1x10-2), lower MRD (<1x10-2) and no detectable MRD with 5-year EFS rate of 57%, 82% and 93% respectively. When day 15 MRD was assessed together with Study 8 risk group and NCI risk group in a multivariate risk analysis, day 15 MRD and NCI risk group retained significance, demonstrating the independent predictive value of day 15 MRD. Both high MRD at day 15 and high NCI risk groups were associated with two-fold increase of relative risk of events.In a Cox multivariate analysis of day 15, 33 and 79 MRD, MRD at day 15 retained significance in predicting subsequent relapse and other events (P=0.0122). Patients with high MRD at both day 15 and day 33 appeared to be at highest risk, andiithe combination (day 15 MRD ≥1x10-2 and day 33 MRD ≥1x10-3) could be used for patient stratification. Patients with undetectable MRD at day 15 could be considered for reduced chemotherapy.The use of a second marker in 37 relapsed patients provided additional useful information for 5 patients. Although limited by small numbers, these findings are consistent with earlier studies which concluded that a second marker is important in ensuring reliable and accurate MRD assessment for patient stratification.It is clear that MRD at day 15 of therapy is predictive of outcome in ALL patients treated on a current Australian MRD intervention protocol. It could be used to identify additional patients at high risk of relapse; and therefore it is suggested that MRD at day 15 should be evaluated for all patients in future clinical trials. Earlier tailoring of treatments to best suit different risk groups could lead to further… Advisors/Committee Members: Sutton, Rosemary, Women's & Children's Health, Faculty of Medicine, UNSW.

Subjects/Keywords: Minimal residual disease; Acute lymphoblastic leukemia

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APA (6^th Edition):

Karsa, M. M. (2011). The significance of minimal residual disease at day 15 for predicting relapse in paediatric acute lymphoblastic leukemia. (Masters Thesis). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/51232 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:9908/SOURCE02?view=true

Chicago Manual of Style (16^th Edition):

Karsa, Mawar Murni. “The significance of minimal residual disease at day 15 for predicting relapse in paediatric acute lymphoblastic leukemia.” 2011. Masters Thesis, University of New South Wales. Accessed February 28, 2021. http://handle.unsw.edu.au/1959.4/51232 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:9908/SOURCE02?view=true.

MLA Handbook (7^th Edition):

Karsa, Mawar Murni. “The significance of minimal residual disease at day 15 for predicting relapse in paediatric acute lymphoblastic leukemia.” 2011. Web. 28 Feb 2021.

Vancouver:

Karsa MM. The significance of minimal residual disease at day 15 for predicting relapse in paediatric acute lymphoblastic leukemia. [Internet] [Masters thesis]. University of New South Wales; 2011. [cited 2021 Feb 28]. Available from: http://handle.unsw.edu.au/1959.4/51232 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:9908/SOURCE02?view=true.

Council of Science Editors:

Karsa MM. The significance of minimal residual disease at day 15 for predicting relapse in paediatric acute lymphoblastic leukemia. [Masters Thesis]. University of New South Wales; 2011. Available from: http://handle.unsw.edu.au/1959.4/51232 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:9908/SOURCE02?view=true

10. Demere, Hailee. Exploring Stress Levels Experienced by Parents of Children with Acute Lymphoblastic Leukemia .

Degree: 2015, California State University – San Marcos

URL: http://hdl.handle.net/10211.3/138763

► In the United States approximately 3,500 children are diagnosed with acute lymphoblastic leukemia (ALL) each year (Horton & Steuber, 2012). With a considerable amount of… (more)

Subjects/Keywords: Exploring Stress Levels; Acute Lymphoblastic Leukemia; Parents of Children with Acute Lymphoblastic Leukemia

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APA (6^th Edition):

Demere, H. (2015). Exploring Stress Levels Experienced by Parents of Children with Acute Lymphoblastic Leukemia . (Thesis). California State University – San Marcos. Retrieved from http://hdl.handle.net/10211.3/138763

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Demere, Hailee. “Exploring Stress Levels Experienced by Parents of Children with Acute Lymphoblastic Leukemia .” 2015. Thesis, California State University – San Marcos. Accessed February 28, 2021. http://hdl.handle.net/10211.3/138763.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Demere, Hailee. “Exploring Stress Levels Experienced by Parents of Children with Acute Lymphoblastic Leukemia .” 2015. Web. 28 Feb 2021.

Vancouver:

Demere H. Exploring Stress Levels Experienced by Parents of Children with Acute Lymphoblastic Leukemia . [Internet] [Thesis]. California State University – San Marcos; 2015. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10211.3/138763.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Demere H. Exploring Stress Levels Experienced by Parents of Children with Acute Lymphoblastic Leukemia . [Thesis]. California State University – San Marcos; 2015. Available from: http://hdl.handle.net/10211.3/138763

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Gothenburg / Göteborgs Universitet

11. Vennström, Lovisa. Population-based studies on acute leukemias - lessons from the Swedish Adult Acute Leukemia Registry.

Degree: 2011, University of Gothenburg / Göteborgs Universitet

URL: http://hdl.handle.net/2077/25488

► Acute leukemia (AL) is a rare, potentially curable, aggressive neoplasm of hematopoietic origin. AL is a heterogeneous disease and is further subdivided according to clinical… (more)

▼ Acute leukemia (AL) is a rare, potentially curable, aggressive neoplasm of hematopoietic origin. AL is a heterogeneous disease and is further subdivided according to clinical and biological features. The aims were to investigate: i) the incidence and survival of adult AL in regions with socioeconomic differences, ii) the outcome of acute promyelocytic leukemia (APL) with particular emphasis on the course of disease during the first weeks of diagnosis, iii) the disease characteristics and survival in patients aged 10-30 years, with acute myeloid leukemia (AML). We have investigated these issues in population-based materials; the first two studies were based on data from the Swedish Cancer Registry and the other four studies were based on data from the Swedish Adult Acute Leukemia Registry (SAALR). Comparisons were made with Estonia on incidence and survival of AL and with the Nordic Society for Paediatric Haematology and Oncology (NOPHO) and adult registries in Denmark and Norway for young AML patients. The incidence of de novo AL was higher in western Sweden than in Estonia for patients aged ≥ 65 years. The 5-year relative survival for AL in patients aged 16-64 years was better in western Sweden than in Estonia and there was a significant improvement in outcome in western Sweden during 1982-1996. The differences in survival between the regions had decreased during the period 1997-2001; a dramatical improvement of survival was seen in Estonia, while no further improvement was recorded in western Sweden. In a population-based study of APL, 29% of patients died within 30 days from diagnosis, 41% due to hemorrhage. The early mortality was higher than described in randomized trials. There were no differences in survival for young AML patients whether treated according to pediatric or adult treatment protocols. Age was not found to be an independent prognostic marker for outcome. Studies from population-based materials provide real world data, an important complement to data from randomized trials. Observational studies from population-based registries with high coverage can improve the epidemiological knowledge and can also describe unknown problems that need further investigation in randomized trials.

Subjects/Keywords: Acute leukemia; population-based; incidence; survival; acute myeloid leukemia; acute lymphoblastic leukemia; acute promyelocytic leukemia; early death

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APA (6^th Edition):

Vennström, L. (2011). Population-based studies on acute leukemias - lessons from the Swedish Adult Acute Leukemia Registry. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/25488

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Vennström, Lovisa. “Population-based studies on acute leukemias - lessons from the Swedish Adult Acute Leukemia Registry.” 2011. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed February 28, 2021. http://hdl.handle.net/2077/25488.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Vennström, Lovisa. “Population-based studies on acute leukemias - lessons from the Swedish Adult Acute Leukemia Registry.” 2011. Web. 28 Feb 2021.

Vancouver:

Vennström L. Population-based studies on acute leukemias - lessons from the Swedish Adult Acute Leukemia Registry. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 2011. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/2077/25488.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Vennström L. Population-based studies on acute leukemias - lessons from the Swedish Adult Acute Leukemia Registry. [Thesis]. University of Gothenburg / Göteborgs Universitet; 2011. Available from: http://hdl.handle.net/2077/25488

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Erasmus University Rotterdam

12. A. van der Veer (Arian). B-Cell Precursor Abnormalities in Childhood Acute Lymphoblastic Leukemia.

Degree: 2014, Erasmus University Rotterdam

URL: http://hdl.handle.net/1765/51427

► markdownabstract__Abstract__ Despite the improvement in prognosis of childhood acute lymphoblastic leukemia (ALL) due to the implementation of relapse risk stratification, the majoritiy of relapses occurs… (more)

Subjects/Keywords: childhood leukemia; prognostic markers; therapy; B-cells; acute lymphoblastic leukemia; children

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

(Arian), A. v. d. V. (2014). B-Cell Precursor Abnormalities in Childhood Acute Lymphoblastic Leukemia. (Thesis). Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/51427

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

(Arian), A. van der Veer. “B-Cell Precursor Abnormalities in Childhood Acute Lymphoblastic Leukemia.” 2014. Thesis, Erasmus University Rotterdam. Accessed February 28, 2021. http://hdl.handle.net/1765/51427.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

(Arian), A. van der Veer. “B-Cell Precursor Abnormalities in Childhood Acute Lymphoblastic Leukemia.” 2014. Web. 28 Feb 2021.

Vancouver:

(Arian) AvdV. B-Cell Precursor Abnormalities in Childhood Acute Lymphoblastic Leukemia. [Internet] [Thesis]. Erasmus University Rotterdam; 2014. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1765/51427.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

(Arian) AvdV. B-Cell Precursor Abnormalities in Childhood Acute Lymphoblastic Leukemia. [Thesis]. Erasmus University Rotterdam; 2014. Available from: http://hdl.handle.net/1765/51427

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Queens University

13. Woodcroft, Mark. Towards a B-Lymphoid Model of E2A-PBX1-Mediated Leukemogenesis: Evaluating the Impact of Hematopoietic Cell of Origin on the Transformation Properties of a Leukemogenic Transcription Factor .

Degree: Pathology and Molecular Medicine, 2013, Queens University

URL: http://hdl.handle.net/1974/8243

► The t(1;19) chromosomal translocation is present in 5% of acute lymphoblastic leukemia (ALL) cases and leads to expression of the oncogenic transcription factor, E2A-PBX1. Although… (more)

▼ The t(1;19) chromosomal translocation is present in 5% of acute lymphoblastic leukemia (ALL) cases and leads to expression of the oncogenic transcription factor, E2A-PBX1. Although t(1;19) is exclusively associated with pre-B ALL in clinical cases, murine models produce myeloid or T-lymphoid leukemias, which are not representative of the clinical disease. In this work, we have advanced progress towards the development an E2A-PBX1-driven experimental leukemia model. We initially determined that lineage-negative (lin-) hematopoietic progenitors expressing E2A-PBX1 expression fail to repopulate the B-lymphoid lineage when transplanted into irradiated recipient mice. Furthermore, E2A-PBX1 expressing, lin- fetal liver progenitors (FLPs) fail to differentiate into B-lymphocytes ex vivo. The majority of E2A-PBX1-expressing FLPs manifested an immature phenotype and displayed stem cell factor (SCF)-dependency and enhanced self-renewal. Additionally, these cells retained myeloid potential upon transplantation or stimulation with granulocyte macrophage colony-stimulating factor (GM-CSF). DNA binding was required for the differentiation block, suggesting that E2A-PBX1 target genes are incompatible with B-lineage specification. E2A-PBX1 FLPs had a stem cell like gene expression profile, including up-regulation of the leukemic transcription factors, Hoxa9 and Meis1. These findings explain why E2A-PBX1-driven bone marrow transplant models fail to generate B-lymphoid disease and suggest that future efforts in developing a model of E2A-PBX1-driven pre-B ALL leukemia should focus on expressing E2A-PBX1 subsequent to B-lymphoid commitment. In an attempt to override the B-lymphoid differentiation block, we next expressed E2A-PBX1 in primary pre-B cells. E2A-PBX1 induced an apoptotic response in pre-B cells, which was consistent with previous observations. Since pre-B ALL induction requires secondary genetic events, we attempted to abrogate these E2A-PBX1-mediated effects by modulating expression of the Cdkn2a locus. Loss of Cdkn2a through deletion or Bmi1 overexpression failed to ameliorate the apoptotic response, suggesting that E2A-PBX1 mediated apoptosis occurs independently of Cdkn2a in murine pre-B cells. However, in the absence of Cdkn2a, co-expression of constitutively active MerTK or Ras attenuated the E2A-PBX1 mediated apoptosis. Cumulatively, these results support the notion that t(1;19) occurs subsequent to B-lymphoid commitment and requires multiple secondary genetic lesions. Data presented in this thesis represents crucial initiating steps towards the development of a pre-B ALL model mediated by E2A-PBX1.

Subjects/Keywords: Hematopoiesis ; E2A-PBX1 ; Acute Lymphoblastic Leukemia ; t(1; 19) ; Leukemia

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APA (6^th Edition):

Woodcroft, M. (2013). Towards a B-Lymphoid Model of E2A-PBX1-Mediated Leukemogenesis: Evaluating the Impact of Hematopoietic Cell of Origin on the Transformation Properties of a Leukemogenic Transcription Factor . (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/8243

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Woodcroft, Mark. “Towards a B-Lymphoid Model of E2A-PBX1-Mediated Leukemogenesis: Evaluating the Impact of Hematopoietic Cell of Origin on the Transformation Properties of a Leukemogenic Transcription Factor .” 2013. Thesis, Queens University. Accessed February 28, 2021. http://hdl.handle.net/1974/8243.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Woodcroft, Mark. “Towards a B-Lymphoid Model of E2A-PBX1-Mediated Leukemogenesis: Evaluating the Impact of Hematopoietic Cell of Origin on the Transformation Properties of a Leukemogenic Transcription Factor .” 2013. Web. 28 Feb 2021.

Vancouver:

Woodcroft M. Towards a B-Lymphoid Model of E2A-PBX1-Mediated Leukemogenesis: Evaluating the Impact of Hematopoietic Cell of Origin on the Transformation Properties of a Leukemogenic Transcription Factor . [Internet] [Thesis]. Queens University; 2013. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1974/8243.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Woodcroft M. Towards a B-Lymphoid Model of E2A-PBX1-Mediated Leukemogenesis: Evaluating the Impact of Hematopoietic Cell of Origin on the Transformation Properties of a Leukemogenic Transcription Factor . [Thesis]. Queens University; 2013. Available from: http://hdl.handle.net/1974/8243

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Anna University

14. Priscilla R. Efficient hierarchical clustering approaches for analyzing ALL AML microarray gene expression data;.

Degree: Analyzing ALL AML microarray gene expression data, 2014, Anna University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/24079

►

Bioinformatics is the application of statistics and computer science to the field of molecular biology The field of bioinformatics has come to mean the application… (more)

▼

Bioinformatics is the application of statistics and computer science to the field of molecular biology The field of bioinformatics has come to mean the application of mathematics statistics and information technology to the biological sciences and the bioinformatics of microarray is the answer to that challenge In all living organisms the genetic content is encoded in information units referred to as genes The whole set of genes of an organism is referred to as its genome The design of microarray experiments is needed to acquire analyze store and share the genetic information with other scientists Micro arrays have acquired special significance in the field of bioinformatics as they consist of an ordered collection of thousands of different Deoxyribonucleic Acid sequences that can be used to measure both DNA and Ribonucleic Acid variations In particular microarrays are considered a breakthrough technology in biology facilitating the quantitative study of thousands of genes simultaneously from a single sample of cells The Gene Expression profiling helps in understanding the fundamental cause of gene behaviour the growth of genes identifying new ailments such as cancer and also analysing their molecular pharmacology DNA microarray technology allows biologists and medical experts to measure the expressiveness of thousands of genes of a tissue sample in a single experiment , which also helps to identify the cancerous gene However newlinethe information that is generated from the experiments cannot be processed or analyzed manually because of its large size and high complexity In the case of cancer study machine learning algorithms have become valuable tools to identify the cancerous genes from the thousands of possible genes Machine learning techniques can be divided into three major groups based on the types of problems they can solve namely supervised semi supervised and unsupervised learning techniques newline newline

References p.151-162

Advisors/Committee Members: Swamynathan S.

Subjects/Keywords: Acute Lymphoblastic Leukemia; Acute Myeloid Leukemia; Bioinformatics; Gene Expression; Information and communication engineering; Micro-arrays

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APA (6^th Edition):

R, P. (2014). Efficient hierarchical clustering approaches for analyzing ALL AML microarray gene expression data;. (Thesis). Anna University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/24079

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

R, Priscilla. “Efficient hierarchical clustering approaches for analyzing ALL AML microarray gene expression data;.” 2014. Thesis, Anna University. Accessed February 28, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/24079.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

R, Priscilla. “Efficient hierarchical clustering approaches for analyzing ALL AML microarray gene expression data;.” 2014. Web. 28 Feb 2021.

Vancouver:

R P. Efficient hierarchical clustering approaches for analyzing ALL AML microarray gene expression data;. [Internet] [Thesis]. Anna University; 2014. [cited 2021 Feb 28]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/24079.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

R P. Efficient hierarchical clustering approaches for analyzing ALL AML microarray gene expression data;. [Thesis]. Anna University; 2014. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/24079

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Cincinnati

15. Bishop, Michael W., M.D. Therapy-Related Events and Health-Related Quality of Life for Children with Leukemia and Lymphoma.

Degree: MS, Medicine: Clinical and Translational Research, 2012, University of Cincinnati

URL: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1342544150

► Purpose: To identify associations between specific therapy-related events such as length of hospitalization and neuropathic pain with health-related quality of life (HRQOL) outcomes for… (more)

▼ Purpose: To identify associations between specific therapy-related events such as length of hospitalization and neuropathic pain with health-related quality of life (HRQOL) outcomes for children with acute lymphoblastic leukemia and lymphoblastic lymphoma. Hypothesis: In children (ages 2 – 30 years) with acute lymphoblastic leukemia (ALL) or lymphoblastic lymphoma, poor health-related quality of life (HRQOL) scores as measured by the PedsQL modules during low-intensity “maintenance” therapy are significantly associated with increased care measures during the initial phases of therapy, including prolonged hospitalization and use of narcotics or neuropathic pain medications. Specific Aims:1.To evaluate the relationship between extended hospitalization time (as defined by total days or weeks admitted, or by number of unanticipated admissions) during intensive phases of therapy, and HRQOL scores during maintenance therapy in children ages 2 years and older with ALL or lymphoblastic lymphoma. 2. To evaluate the relationship between increased supportive care for pain by use of patient-controlled analgesia (PCA), long acting oral narcotics, or the use of neuropathic pain medications during therapy, and HRQOL scores during maintenance therapy in children ages 2 years and older with ALL or lymphoblastic lymphoma. Methods: A cross-sectional single institution pilot study was performed for children with ALL or lymphoblastic lymphoma who had reached maintenance therapy or had recently completed treatment. HRQOL scores were obtained using the PedsQL 4.0 Generic Core Scales and PedsQL 3.0 Cancer Module, and retrospective chart review was performed for each patient. Results: 57 subjects were available for analysis. Multiple regression analysis found that longer total time of hospitalization correlated with poorer overall PedsQL 4.0 summary scores (p = 0.002). Age, time since the start of maintenance therapy, and the number of unscheduled hospitalizations were independently prognostic for physical scores. The use of neuropathic pain medications was strongly associated with poorer social functioning scores (OR 4.58, p = 0.03), the number of weeks hospitalized also negatively influenced social scores (OR 0.90, p = 0.04). Conclusions: Specific therapy-related events can predict changes in HRQOL outcomes for children and adolescents with ALL and lymphoblastic lymphoma. Future research should include prospective evaluations of HRQOL outcomes throughout therapy and determine what interventions may improve HRQOL outcomes. Advisors/Committee Members: Haynes, Erin Nicole (Committee Chair).

Subjects/Keywords: Oncology; acute lymphoblastic leukemia; lymphoblastic lymphoma; health-related quality of life; pediatric

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bishop, Michael W., M. D. (2012). Therapy-Related Events and Health-Related Quality of Life for Children with Leukemia and Lymphoma. (Masters Thesis). University of Cincinnati. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=ucin1342544150

Chicago Manual of Style (16^th Edition):

Bishop, Michael W., M D. “Therapy-Related Events and Health-Related Quality of Life for Children with Leukemia and Lymphoma.” 2012. Masters Thesis, University of Cincinnati. Accessed February 28, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1342544150.

MLA Handbook (7^th Edition):

Bishop, Michael W., M D. “Therapy-Related Events and Health-Related Quality of Life for Children with Leukemia and Lymphoma.” 2012. Web. 28 Feb 2021.

Vancouver:

Bishop, Michael W. MD. Therapy-Related Events and Health-Related Quality of Life for Children with Leukemia and Lymphoma. [Internet] [Masters thesis]. University of Cincinnati; 2012. [cited 2021 Feb 28]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1342544150.

Council of Science Editors:

Bishop, Michael W. MD. Therapy-Related Events and Health-Related Quality of Life for Children with Leukemia and Lymphoma. [Masters Thesis]. University of Cincinnati; 2012. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1342544150

Universiteit Utrecht

16. Maat, J.V. Incidence, Risk Factors and Prophylaxis use Concerning Invasive Fungal Infections in Children with Newly Diagnosed Acute Lymphoblastic Leukemia.

Degree: 2015, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/316340

► Background. With achievable acute lymphoblastic leukemia (ALL) survival rates of 80-90%, non-leukemic events lead to a high proportion of treatment failure. An important cause of… (more)

Subjects/Keywords: Childhood Acute Lymphoblastic Leukemia; fungal infection; incidence; prophylaxis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Maat, J. V. (2015). Incidence, Risk Factors and Prophylaxis use Concerning Invasive Fungal Infections in Children with Newly Diagnosed Acute Lymphoblastic Leukemia. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/316340

Chicago Manual of Style (16^th Edition):

Maat, J V. “Incidence, Risk Factors and Prophylaxis use Concerning Invasive Fungal Infections in Children with Newly Diagnosed Acute Lymphoblastic Leukemia.” 2015. Masters Thesis, Universiteit Utrecht. Accessed February 28, 2021. http://dspace.library.uu.nl:8080/handle/1874/316340.

MLA Handbook (7^th Edition):

Maat, J V. “Incidence, Risk Factors and Prophylaxis use Concerning Invasive Fungal Infections in Children with Newly Diagnosed Acute Lymphoblastic Leukemia.” 2015. Web. 28 Feb 2021.

Vancouver:

Maat JV. Incidence, Risk Factors and Prophylaxis use Concerning Invasive Fungal Infections in Children with Newly Diagnosed Acute Lymphoblastic Leukemia. [Internet] [Masters thesis]. Universiteit Utrecht; 2015. [cited 2021 Feb 28]. Available from: http://dspace.library.uu.nl:8080/handle/1874/316340.

Council of Science Editors:

Maat JV. Incidence, Risk Factors and Prophylaxis use Concerning Invasive Fungal Infections in Children with Newly Diagnosed Acute Lymphoblastic Leukemia. [Masters Thesis]. Universiteit Utrecht; 2015. Available from: http://dspace.library.uu.nl:8080/handle/1874/316340

Universidade Federal de Sergipe

17. Simone Santana Viana. ANTICORPOS VACINAIS VIRAIS EM CRIANÇAS PORTADORAS DE LEUCEMIA LINFÓIDE AGUDA APÓS QUIMIOTERAPIA.

Degree: 2009, Universidade Federal de Sergipe

URL: http://bdtd.ufs.br/tde_busca/arquivo.php?codArquivo=301

►

O papel da vacinação em crianças que receberam quimioterapia (QT) para neoplasias malignas, inclusive leucemia linfóide aguda (LLA), continua controverso. Tanto a doença quanto o… (more)

▼

O papel da vacinação em crianças que receberam quimioterapia (QT) para neoplasias malignas, inclusive leucemia linfóide aguda (LLA), continua controverso. Tanto a doença quanto o tratamento afetam o sistema imune. As alterações podem ocorrer pela neutropenia, que leva ao risco imediato de infecções bacterianas e fúngicas, pela perda dos níveis protetores de anticorpos adquiridos por imunizações prévias, como também pela eficácia duvidosa das reimunizações. Por isso, diferentes abordagens são aplicadas em vários países e o melhor esquema de vacinação não está bem definido. Além disso, as recomendações existentes, construídas principalmente com baixos níveis de evidência, nem sempre são seguidas pelos oncologistas na prática clínica e as referências de literatura quanto ao tema são poucas. A escassez de dados de ensaios controlados, tanto para a imunidade residual contra antígenos vacinais no final do tratamento de crianças com LLA, como para a capacidade desses pacientes responderem aos reforços vacinais, não permitiu até o momento o desenvolvimento de diretrizes, sendo, então, necessárias novas avaliações. Foi realizado um estudo do tipo ensaio clínico controlado aberto, para avaliar as taxas de proteção contra antígenos vacinais virais em crianças tratadas para LLA após término da QT, e da aplicação de uma dose de reforço vacinal. O estado imunológico contra hepatite B, sarampo, rubéola e caxumba foi avaliado em 33 pacientes e comparado com um grupo controle. Para análise estatística foram utilizados o teste do qui-quadrado e exato de Fisher para variáveis categóricas e teste de Mann-Whitney para variáveis contínuas. Observouse uma elevada proporção de indivíduos não imunes ao sarampo (75,9%) à rubéola (51,7%) e à hepatite B (59,3%) ao final da QT para LLA. Após a administração de uma dose vacinal de reforço, ocorreu a recuperação para todos os antígenos testados sendo estatisticamente significante para sarampo (p = 0,0422) e hepatite B (p = 0,0357). Recomenda-se, portanto, uma dose das vacinas tríplice viral e hepatite B após recuperação hematológica e posterior avaliação dos títulos de anticorpos vacinais para intervenções individualizadas.

The role of vaccination in children, who received chemotherapy for malignancies, including acute lymphoblastic leukemia (ALL), remains controversial. Both the disease and treatment affect the immune system. Changes may occur by neutropenia, leading to immediate risk of bacterial and fungal infections, loss protective levels of antibody by previous immunizations, as well as the questionable efficacy of revaccination. Therefore, different approaches are applied in several countries and the best vaccination schedule is not well defined yet. Moreover, the existing recommendations, mainly built on low levels of evidence, are not always followed by oncologists in clinical practice and there are still few references to literature on the subject. The paucity of data from controlled trials on both residual immunity against vaccine antigens at the end of treatment of children with ALL…

Advisors/Committee Members: Rosana Cipolotti.

Subjects/Keywords: Imunização; leucemia linfóide aguda; quimioterapia; MEDICINA; Immunization; acute lymphoblastic leukemia; chemotherapy

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Viana, S. S. (2009). ANTICORPOS VACINAIS VIRAIS EM CRIANÇAS PORTADORAS DE LEUCEMIA LINFÓIDE AGUDA APÓS QUIMIOTERAPIA. (Thesis). Universidade Federal de Sergipe. Retrieved from http://bdtd.ufs.br/tde_busca/arquivo.php?codArquivo=301

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Viana, Simone Santana. “ANTICORPOS VACINAIS VIRAIS EM CRIANÇAS PORTADORAS DE LEUCEMIA LINFÓIDE AGUDA APÓS QUIMIOTERAPIA.” 2009. Thesis, Universidade Federal de Sergipe. Accessed February 28, 2021. http://bdtd.ufs.br/tde_busca/arquivo.php?codArquivo=301.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Viana, Simone Santana. “ANTICORPOS VACINAIS VIRAIS EM CRIANÇAS PORTADORAS DE LEUCEMIA LINFÓIDE AGUDA APÓS QUIMIOTERAPIA.” 2009. Web. 28 Feb 2021.

Vancouver:

Viana SS. ANTICORPOS VACINAIS VIRAIS EM CRIANÇAS PORTADORAS DE LEUCEMIA LINFÓIDE AGUDA APÓS QUIMIOTERAPIA. [Internet] [Thesis]. Universidade Federal de Sergipe; 2009. [cited 2021 Feb 28]. Available from: http://bdtd.ufs.br/tde_busca/arquivo.php?codArquivo=301.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Viana SS. ANTICORPOS VACINAIS VIRAIS EM CRIANÇAS PORTADORAS DE LEUCEMIA LINFÓIDE AGUDA APÓS QUIMIOTERAPIA. [Thesis]. Universidade Federal de Sergipe; 2009. Available from: http://bdtd.ufs.br/tde_busca/arquivo.php?codArquivo=301

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Louisville

18. Murphy, Emily M. Non-viral transfection efficiencies for the advancement of CAR-T therapy.

Degree: M. Eng., 2019, University of Louisville

URL: 10.18297/etd/3248 ; https://ir.library.louisville.edu/etd/3248

► Leukemias are the most common form of childhood cancer making up 30% of total pediatric oncological cases, and Acute Lymphoblastic Leukemia (ALL) makes up… (more)

Subjects/Keywords: CAR-T; t-cells; transfection; sonoporation; electroporation; acute lymphoblastic leukemia; Therapeutics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Murphy, E. M. (2019). Non-viral transfection efficiencies for the advancement of CAR-T therapy. (Masters Thesis). University of Louisville. Retrieved from 10.18297/etd/3248 ; https://ir.library.louisville.edu/etd/3248

Chicago Manual of Style (16^th Edition):

Murphy, Emily M. “Non-viral transfection efficiencies for the advancement of CAR-T therapy.” 2019. Masters Thesis, University of Louisville. Accessed February 28, 2021. 10.18297/etd/3248 ; https://ir.library.louisville.edu/etd/3248.

MLA Handbook (7^th Edition):

Murphy, Emily M. “Non-viral transfection efficiencies for the advancement of CAR-T therapy.” 2019. Web. 28 Feb 2021.

Vancouver:

Murphy EM. Non-viral transfection efficiencies for the advancement of CAR-T therapy. [Internet] [Masters thesis]. University of Louisville; 2019. [cited 2021 Feb 28]. Available from: 10.18297/etd/3248 ; https://ir.library.louisville.edu/etd/3248.

Council of Science Editors:

Murphy EM. Non-viral transfection efficiencies for the advancement of CAR-T therapy. [Masters Thesis]. University of Louisville; 2019. Available from: 10.18297/etd/3248 ; https://ir.library.louisville.edu/etd/3248

Universidade Federal do Maranhão

19. KARLA NADINNE DE SOUSA ANDRADE. EXPRESSÃO DOS MARCADORES CD56, CD16 E CD57 NA AVALIAÇÃO PROGNÓSTICA DE PACIENTES COM LEUCEMIA LINFÓIDE AGUDA NO ESTADO DO MARANHÃO.

Degree: 2012, Universidade Federal do Maranhão

URL: http://www.tedebc.ufma.br//tde_busca/arquivo.php?codArquivo=749

►

A Leucemia linfóide aguda (LLA) é caracterizada pela proliferação anormal de células linfóides imaturas e representa a neoplasia mais comum em crianças. A avaliação de… (more)

▼

A Leucemia linfóide aguda (LLA) é caracterizada pela proliferação anormal de células linfóides imaturas e representa a neoplasia mais comum em crianças. A avaliação de fatores prognósticos em pacientes com LLA possibilita a implantação de abordagens terapêuticas diferenciadas. A expressão aberrante dos marcadores CD56, CD57 e CD16 pode ser uma forma de avaliar tal prognóstico. O objetivo deste trabalho foi caracterizar os pacientes com LLA e avaliar a influência prognóstica da expressão aberrante dos marcadores CD56, CD16 e CD57 na LLA. Foram avaliados 40 pacientes, atendidos no Instituto Maranhense de Oncologia Aldenora Bello (IMOAB), em São Luís MA, no período de março de 2010 a outubro de 2011. Os pacientes foram diagnosticados com LLA, segundo os critérios morfo-citoquímicos e imunofenotípicos. A expressão dos marcadores foi determinada através da citometria de fluxo e os dados clínicos foram obtidos através da revisão de prontuários. Dois grupos foram divididos quanto à expressão ou não dos referidos marcadores e comparados em relação às variáveis prognósticas. A média de idade na amostra foi de 6,28 anos, sendo o sexo masculino predominante (60,0%). A média de blastos contados na medula óssea (MO) e sangue periférico (SP) foram de 77,0 e 39,6, respectivamente. A morfologia L1 dos blastos da MO foi a mais frequente (80,0%). O perfil do hemograma, ao diagnóstico, indicou: 24.061 leucócitos/mm3, 56.510 plaquetas/mm3 e 8,0 g/dL de hemoglobina. De acordo com a classificação GBTLI-99, 60,0% dos pacientes se encontravam no grupo de baixo risco de recidiva e ao final da fase de indução do tratamento (D29), 70,0% dos pacientes alcançaram a remissão. Os pacientes portadores de LLA T apresentaram média de idade (10,6 anos; p= 0,0204) e leucometria (48.200/mm3; p= 0,0167) significativamente mais altas do que os pacientes com LLA B. 80,0% dos pacientes expressaram o marcador CD56 e nenhum paciente expressou o CD16 e/ou o CD57. Os pacientes que não expressaram o marcador CD56 tinham idade significativamente maior daqueles que o expressaram (9,3 anos; p= 0,0353). Para os pacientes portadores de LLA B, a média de blastos do SP dos pacientes que expressaram o marcador CD56 foi maior do que a média dos que não o expressaram (41,1; p= 0,0226). Conclui-se que a expressão do CD56 sugere um pior prognóstico para os pacientes com LLA B, em virtude de uma média significativamente maior de blastos contados no SP encontrada no nosso estudo, contudo, um maior número de casos e um maior tempo de observação seriam necessários para enfatizar melhor esta evidência.

The acute lymphoblastic leukemia (ALL) is characterized by abnormal proliferation of immature lymphoid cells and represents the most common cancer in children. The evaluation of prognostic factors in patients with ALL enables the implantation of different therapeutic approaches. The aberrant expression of markers CD56, CD57 and CD16 may be a way to assess this prognosis. The objective of this study was to characterize patients with ALL and to evaluate the prognostic influence…

Advisors/Committee Members: RAIMUNDO ANTONIO DA SILVA, Raimundo Antonio Gomes Oliveira.

Subjects/Keywords: Leucemia linfóide aguda; Prognóstico; CANCEROLOGIA; Acute lymphoblastic leukemia; Prognosis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

ANDRADE, K. N. D. S. (2012). EXPRESSÃO DOS MARCADORES CD56, CD16 E CD57 NA AVALIAÇÃO PROGNÓSTICA DE PACIENTES COM LEUCEMIA LINFÓIDE AGUDA NO ESTADO DO MARANHÃO. (Thesis). Universidade Federal do Maranhão. Retrieved from http://www.tedebc.ufma.br//tde_busca/arquivo.php?codArquivo=749

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

ANDRADE, KARLA NADINNE DE SOUSA. “EXPRESSÃO DOS MARCADORES CD56, CD16 E CD57 NA AVALIAÇÃO PROGNÓSTICA DE PACIENTES COM LEUCEMIA LINFÓIDE AGUDA NO ESTADO DO MARANHÃO.” 2012. Thesis, Universidade Federal do Maranhão. Accessed February 28, 2021. http://www.tedebc.ufma.br//tde_busca/arquivo.php?codArquivo=749.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

ANDRADE, KARLA NADINNE DE SOUSA. “EXPRESSÃO DOS MARCADORES CD56, CD16 E CD57 NA AVALIAÇÃO PROGNÓSTICA DE PACIENTES COM LEUCEMIA LINFÓIDE AGUDA NO ESTADO DO MARANHÃO.” 2012. Web. 28 Feb 2021.

Vancouver:

ANDRADE KNDS. EXPRESSÃO DOS MARCADORES CD56, CD16 E CD57 NA AVALIAÇÃO PROGNÓSTICA DE PACIENTES COM LEUCEMIA LINFÓIDE AGUDA NO ESTADO DO MARANHÃO. [Internet] [Thesis]. Universidade Federal do Maranhão; 2012. [cited 2021 Feb 28]. Available from: http://www.tedebc.ufma.br//tde_busca/arquivo.php?codArquivo=749.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

ANDRADE KNDS. EXPRESSÃO DOS MARCADORES CD56, CD16 E CD57 NA AVALIAÇÃO PROGNÓSTICA DE PACIENTES COM LEUCEMIA LINFÓIDE AGUDA NO ESTADO DO MARANHÃO. [Thesis]. Universidade Federal do Maranhão; 2012. Available from: http://www.tedebc.ufma.br//tde_busca/arquivo.php?codArquivo=749

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

20. Takahashi, Hiroyoshi. Autophagy is required for cell survival under L-asparaginase–induced metabolic stress in acute lymphoblastic leukemia cells : オートファジーは急性リンパ性白血病細胞においてL-アスパラギナーゼ誘導性代謝ストレス下での細胞生存に必要である.

Degree: 博士（医学）, 2017, Hamamatsu University School of Medicine / 浜松医科大学

URL: http://hdl.handle.net/10271/3334

►

L-asparaginase has been used for more than three decades in acute lymphoblastic leukemia (ALL) patients and remains an essential drug in the treatment of ALL.… (more)

Subjects/Keywords: autophagy; acute lymphoblastic leukemia; L-asparaginase; reactive oxygen species; p53

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Takahashi, H. (2017). Autophagy is required for cell survival under L-asparaginase–induced metabolic stress in acute lymphoblastic leukemia cells : オートファジーは急性リンパ性白血病細胞においてL-アスパラギナーゼ誘導性代謝ストレス下での細胞生存に必要である. (Thesis). Hamamatsu University School of Medicine / 浜松医科大学. Retrieved from http://hdl.handle.net/10271/3334

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Takahashi, Hiroyoshi. “Autophagy is required for cell survival under L-asparaginase–induced metabolic stress in acute lymphoblastic leukemia cells : オートファジーは急性リンパ性白血病細胞においてL-アスパラギナーゼ誘導性代謝ストレス下での細胞生存に必要である.” 2017. Thesis, Hamamatsu University School of Medicine / 浜松医科大学. Accessed February 28, 2021. http://hdl.handle.net/10271/3334.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Takahashi, Hiroyoshi. “Autophagy is required for cell survival under L-asparaginase–induced metabolic stress in acute lymphoblastic leukemia cells : オートファジーは急性リンパ性白血病細胞においてL-アスパラギナーゼ誘導性代謝ストレス下での細胞生存に必要である.” 2017. Web. 28 Feb 2021.

Vancouver:

Takahashi H. Autophagy is required for cell survival under L-asparaginase–induced metabolic stress in acute lymphoblastic leukemia cells : オートファジーは急性リンパ性白血病細胞においてL-アスパラギナーゼ誘導性代謝ストレス下での細胞生存に必要である. [Internet] [Thesis]. Hamamatsu University School of Medicine / 浜松医科大学; 2017. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10271/3334.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Takahashi H. Autophagy is required for cell survival under L-asparaginase–induced metabolic stress in acute lymphoblastic leukemia cells : オートファジーは急性リンパ性白血病細胞においてL-アスパラギナーゼ誘導性代謝ストレス下での細胞生存に必要である. [Thesis]. Hamamatsu University School of Medicine / 浜松医科大学; 2017. Available from: http://hdl.handle.net/10271/3334

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Minnesota

21. Zierhut, Heather Ann. Hereditary and inborn etiology of pediatric cancer.

Degree: PhD, Molecular, Cellular, Developmental Biology and Genetics, 2012, University of Minnesota

URL: http://purl.umn.edu/155014

► The etiology of childhood cancer remains largely elusive. In rare cases, genetic mutations and environmental exposures such as radiation are known causes. For the vast… (more)

▼ The etiology of childhood cancer remains largely elusive. In rare cases, genetic mutations and environmental exposures such as radiation are known causes. For the vast majority of childhood cancer patients, there is no known cause for their disease. With an increasing number of childhood cancer survivors, the need to understand disease for patients and their families is becoming even more vital. This dissertation will describe three different investigations to understand the role of genetic or inborn factors play in the etiology of childhood cancer. The first study reviewed investigates family history in acute lymphoblastic leukemia (ALL) patients. Family history information can provide insight into the genetic (and/or shared environmental) basis of an illness. We investigated the association of family history of specific cancers and non-malignant diseases in one of the largest case-control studies of childhood ALL conducted to date. In this study, family history of cancer was not significantly more frequent among ALL cases compared to controls. The likelihood of family history of esophageal cancer was lower in ALL cases as compared to controls but the number of affected relatives was small in both groups and due to multiple comparisons performed in the statistical analysis may not be a true association. For selected non-malignant conditions, significant inverse associations with family history of allergic disease, food and drug allergy, rheumatoid arthritis and risk of ALL were observed. The second study reviewed focuses on the association of rib anomalies and childhood cancer. Congenital anomalies have been associated with childhood cancer syndromes in many large epidemiological studies using population based registries. This study sought to better understand and more robustly describe the association between childhood cancer and morphological defects of the ribs in a hospital-based case-control United States population. Our results indicate a modest but fairly robust association between rib anomalies (RA) and childhood cancer. RAs were associated with increased odds of the individual cancer types AML, renal tumors, and hepatoblastoma. The final study reviewed examines common genetic variation associated with pediatric osteosarcoma (OS). A small subset of individuals develop OS due to a hereditary predisposition syndrome such as Li Fraumeni, Retinoblastoma, or Rothmund-Thompson syndrome. Mutations in the TP53, RB, and RECQL4 genes are highly penetrant and can confer up to a 90% chance of developing OS. We hypothesized that single nucleotide polymorphisms (SNPs) in these genes, and those in the same pathways affect risk of OS less drastically. In this analysis, we conducted a case-parent triad study to examine main effects of DNA repair and metabolism genes in pediatric OS. We identified a nonsynonymous SNP in RECQL4 that was most associated with OS although not significantly after correction for multiple comparisons. No significant associations of DNA repair genes previously described were replicated in this…

Subjects/Keywords: Acute lymphoblastic leukemia; Childhood cancer; Ostesarcoma; Rib anomalies

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zierhut, H. A. (2012). Hereditary and inborn etiology of pediatric cancer. (Doctoral Dissertation). University of Minnesota. Retrieved from http://purl.umn.edu/155014

Chicago Manual of Style (16^th Edition):

Zierhut, Heather Ann. “Hereditary and inborn etiology of pediatric cancer.” 2012. Doctoral Dissertation, University of Minnesota. Accessed February 28, 2021. http://purl.umn.edu/155014.

MLA Handbook (7^th Edition):

Zierhut, Heather Ann. “Hereditary and inborn etiology of pediatric cancer.” 2012. Web. 28 Feb 2021.

Vancouver:

Zierhut HA. Hereditary and inborn etiology of pediatric cancer. [Internet] [Doctoral dissertation]. University of Minnesota; 2012. [cited 2021 Feb 28]. Available from: http://purl.umn.edu/155014.

Council of Science Editors:

Zierhut HA. Hereditary and inborn etiology of pediatric cancer. [Doctoral Dissertation]. University of Minnesota; 2012. Available from: http://purl.umn.edu/155014

University of Minnesota

22. Katerndahl, Casey. The balance of STAT5 and NFκB or IKAROS at enhancer networks dictates progenitor B cell survival, proliferation, and differentiation.

Degree: PhD, Microbiology, Immunology and Cancer Biology, 2015, University of Minnesota

URL: http://hdl.handle.net/11299/191333

► B cell Acute Lymphoblastic Leukemia (B-ALL) arises from transformation of progenitor B cells. The transcription factor STAT5 plays a critical role in B-ALL, as high… (more)

Subjects/Keywords: Acute Lymphoblastic Leukemia; IKAROS; NFkB; STAT5; Super-enhancer

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Katerndahl, C. (2015). The balance of STAT5 and NFκB or IKAROS at enhancer networks dictates progenitor B cell survival, proliferation, and differentiation. (Doctoral Dissertation). University of Minnesota. Retrieved from http://hdl.handle.net/11299/191333

Chicago Manual of Style (16^th Edition):

Katerndahl, Casey. “The balance of STAT5 and NFκB or IKAROS at enhancer networks dictates progenitor B cell survival, proliferation, and differentiation.” 2015. Doctoral Dissertation, University of Minnesota. Accessed February 28, 2021. http://hdl.handle.net/11299/191333.

MLA Handbook (7^th Edition):

Katerndahl, Casey. “The balance of STAT5 and NFκB or IKAROS at enhancer networks dictates progenitor B cell survival, proliferation, and differentiation.” 2015. Web. 28 Feb 2021.

Vancouver:

Katerndahl C. The balance of STAT5 and NFκB or IKAROS at enhancer networks dictates progenitor B cell survival, proliferation, and differentiation. [Internet] [Doctoral dissertation]. University of Minnesota; 2015. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/11299/191333.

Council of Science Editors:

Katerndahl C. The balance of STAT5 and NFκB or IKAROS at enhancer networks dictates progenitor B cell survival, proliferation, and differentiation. [Doctoral Dissertation]. University of Minnesota; 2015. Available from: http://hdl.handle.net/11299/191333

University of Southern California

23. Hsieh, Yao-Te (Stanley). Role of integrin α4 in drug resistant acute lymphoblastic leukemia.

Degree: PhD, Pathobiology, 2013, University of Southern California

URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/250789/rec/5644

► Although cure rates for acute lymphoblastic leukemia (ALL) in children are high, relapse of ALL leads to death in 50-95%. Adult ALL patients have a… (more)

▼ Although cure rates for acute lymphoblastic leukemia (ALL) in children are high, relapse of ALL leads to death in 50-95%. Adult ALL patients have a survival rate of only 40%. Even survived, patients often suffer from late-term secondary toxic effects of current treatments. Therefore, chemotherapeutic drug resistance of ALL cells remains a major problem and less toxic and more efficient therapies are needed. More than 80% of first relapse of childhood and adult ALL occurs in the bone marrow. Interaction of normal hematopoietic stem cells with the bone marrow (BM) stromal cells has been shown to provide mechanical support and facilitate proliferation and differentiation. BM stromal cells also provide protection of ALL cells from chemotherapy, thus contributing to drug resistance due to the lack of efficacy of current therapies. The exact mechanisms for stroma-mediated chemoprotection and approaches to address this problem remain elusive. In chapter two of this thesis, we summarize how we established a xenograft model of primary ALL cells to evaluate novel therapies. In chapter three, we use this preclinical model of primary ALL and focus on integrin alpha 4 as a central adhesion molecule for stromal-mediated chemoprotection and drug resistance of ALL. Integrin α4 is known to mediate adhesion of normal and malignant B-cell precursors in BM stromal cells. However, the functional modulation of integrin α4 and its consequences for drug resistance in ALL remains to be examined. According to gene expression analyses, integrin α4 is overexpressed in ALL patients and inversely correlated with the survival outcome. Therefore, we tested whether interference with α4-mediated stromal adhesion might be a new ALL treatment strategy. For this purpose, two models of leukemia were used: one pharmacological using antibody, like Tysabri, and small molecule inhibitor, like TBC3486, to target α4 of primary pre-B ALL and later in chapter 4 a genetic model (conditional α4 ablation of BCR-ABL1-induced murine leukemia). Conditional deletion of α4 sensitized murine leukemia cell to chemotherapy, Nilotinib. Adhesion of primary pre-B ALL cells was α4-dependent and inhibiting α4 sensitized primary ALL cells towards chemotherapy, VDL. Combination of chemotherapy with Tysabri prolonged survival of NOD/SCID recipients of primary ALL suggesting adjuvant integrin α4 inhibition as a novel strategy for pre-B ALL. Taken together, our data demonstrate that integrin α4-blockade with adjuvant chemotherapy can eradicate chemotherapy-resistant leukemia. Advisors/Committee Members: Kim, Yong-Mi (Committee Chair), Chuong, Cheng-Ming (Committee Member), Hofman, Florence M. (Committee Member), Heisterkamp, Nora (Committee Member), Mittelman, Steven D. (Committee Member).

Subjects/Keywords: acute lymphoblastic leukemia; ALL; integrin; alpha4; drug resistant; Tysabri; TBC3486; Natalizumab

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hsieh, Y. (. (2013). Role of integrin α4 in drug resistant acute lymphoblastic leukemia. (Doctoral Dissertation). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/250789/rec/5644

Chicago Manual of Style (16^th Edition):

Hsieh, Yao-Te (Stanley). “Role of integrin α4 in drug resistant acute lymphoblastic leukemia.” 2013. Doctoral Dissertation, University of Southern California. Accessed February 28, 2021. http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/250789/rec/5644.

MLA Handbook (7^th Edition):

Hsieh, Yao-Te (Stanley). “Role of integrin α4 in drug resistant acute lymphoblastic leukemia.” 2013. Web. 28 Feb 2021.

Vancouver:

Hsieh Y(. Role of integrin α4 in drug resistant acute lymphoblastic leukemia. [Internet] [Doctoral dissertation]. University of Southern California; 2013. [cited 2021 Feb 28]. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/250789/rec/5644.

Council of Science Editors:

Hsieh Y(. Role of integrin α4 in drug resistant acute lymphoblastic leukemia. [Doctoral Dissertation]. University of Southern California; 2013. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/250789/rec/5644

24. Szczepanski, Tomasz. Detection of minimal residual disease in acute lymphoblastic leukemia.

Degree: 2002, Erasmus University Medical Center

URL: http://hdl.handle.net/1765/32026

► textabstractAcute lymphoblastic leukemia (ALL) represents the most frequent malignancy in childhood. Last decades brought enormous progress in ALL treatment and in the understanding of ALL… (more)

▼ textabstractAcute lymphoblastic leukemia (ALL) represents the most frequent malignancy in childhood. Last decades brought enormous progress in ALL treatment and in the understanding of ALL biology (see Chapter 1.1 ), but still 20 to 30% of children suffer from relapse and many of them will ultimately die of disease progression. The currently used cytomorphological (microscopic) techniques can only detect 1 to 5% of malignant cells, which is not sufficiently sensitive for identification of patients who are prone to relapse and who might be rescued by treatment intensification. During the past 15 years several approaches have been developed for detection of much lower numbers of malignant cells, i.e. for detection of minimal residual disease (MRD) in various hematopoietic malignancies (see Chapter 1.2). Monitoring of MRD with sensitivities of 1 Q-4 to 1 o-6 (i.e. one malignant cell within the background of 104 to 106 normal cells) has significantly higher prognostic value than conventional cytomorphological techniques and other clinical parameters at diagnosis and is therefore currently implemented into clinical practice in several hematopoietic malignancies, including ALL. In childhood ALL, detection of MRD most frequently relies on patient-specific immunoglobulin (lg) and T-cell receptor (TCR) gene rearrangements as molecular markers for PCR studies. The junctional regions of rearranged lg and TCR genes are unique "fingerprint-like" sequences, which are assumed to be different in each lymphoid cell and thus also in each lymphoid malignancy. They can be easily identified and characterized for instance by using heteroduplex PCR analysis (see Chapter 2.2) and direct sequencing. This thesis aimed at detailed evaluation of lg and TCR gene rearrangements in ALL with regard to the following aspects: -characterization of lg/TCR gene rearrangements patterns in precursor-BALL and T-ALL; - immunobiological differences between malignant and normal lymphoid cells; -stability of clonal lg/TCR gene rearrangements at relapse of ALL; -applicability of lg/TCR gene rearrangements as PCR targets for detection of MRD. Virtually all precursor-B-ALL (96%) have rearranged lg heavy chain (/GH) genes. In most cases (80-90%) this concerns complete VH-DH-JH rearrangements on at least one allele. Incomplete DH-JH rearrangements could be identified in 22% of patients, being the sole /GH gene rearrangements in only 5% of patients (see Chapter 2.3). Most precursor-B-ALL contain lg kappa (/GK) light chain gene rearrangements (30%) or deletions (50%); 20% of precursor-B-ALL cases even have lg lambda (IGL) gene rearrangements. Deletions in the IGK genes are predominantly mediated via the IGK deleting element (Kde) sequence. Such Kde rearrangements occur in 50% of precursor-B-ALL cases

Subjects/Keywords: acute lymphoblastic leukemia; diagnostics; hematology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Szczepanski, T. (2002). Detection of minimal residual disease in acute lymphoblastic leukemia. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/32026

Chicago Manual of Style (16^th Edition):

Szczepanski, Tomasz. “Detection of minimal residual disease in acute lymphoblastic leukemia.” 2002. Doctoral Dissertation, Erasmus University Medical Center. Accessed February 28, 2021. http://hdl.handle.net/1765/32026.

MLA Handbook (7^th Edition):

Szczepanski, Tomasz. “Detection of minimal residual disease in acute lymphoblastic leukemia.” 2002. Web. 28 Feb 2021.

Vancouver:

Szczepanski T. Detection of minimal residual disease in acute lymphoblastic leukemia. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2002. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1765/32026.

Council of Science Editors:

Szczepanski T. Detection of minimal residual disease in acute lymphoblastic leukemia. [Doctoral Dissertation]. Erasmus University Medical Center; 2002. Available from: http://hdl.handle.net/1765/32026

Queens University

25. Morton, Geoffrey. Data Mining the Genetics of Leukemia .

Degree: Computing, 2010, Queens University

URL: http://hdl.handle.net/1974/5390

► Acute Lymphoblastic Leukemia (ALL) is the most common cancer in children under the age of 15. At present, diagnosis, prognosis and treatment decisions are made… (more)

Subjects/Keywords: Data Mining ; Acute Lymphoblastic Leukemia

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APA (6^th Edition):

Morton, G. (2010). Data Mining the Genetics of Leukemia . (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/5390

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Morton, Geoffrey. “Data Mining the Genetics of Leukemia .” 2010. Thesis, Queens University. Accessed February 28, 2021. http://hdl.handle.net/1974/5390.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Morton, Geoffrey. “Data Mining the Genetics of Leukemia .” 2010. Web. 28 Feb 2021.

Vancouver:

Morton G. Data Mining the Genetics of Leukemia . [Internet] [Thesis]. Queens University; 2010. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1974/5390.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Morton G. Data Mining the Genetics of Leukemia . [Thesis]. Queens University; 2010. Available from: http://hdl.handle.net/1974/5390

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

26. 정, 현주. Effect of Tissue Transglutaminase on Steroid Resistance in T-Cell Acute Lymphoblastic Leukemia.

Degree: 2020, Ajou University

URL: http://repository.ajou.ac.kr/handle/201003/19265 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000030197

►

AIM: To improve survival in patients with glucocorticoid-resistant T-cell acute lymphoblastic leukemia (T-ALL), it is critical to develop new therapeutic strategies to overcome steroid resistance.… (more)

Subjects/Keywords: Tissue transglutaminase; steroid resistance; T-cell acute lymphoblastic leukemia

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APA (6^th Edition):

정, �. (2020). Effect of Tissue Transglutaminase on Steroid Resistance in T-Cell Acute Lymphoblastic Leukemia. (Thesis). Ajou University. Retrieved from http://repository.ajou.ac.kr/handle/201003/19265 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000030197

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

정, 현주. “Effect of Tissue Transglutaminase on Steroid Resistance in T-Cell Acute Lymphoblastic Leukemia.” 2020. Thesis, Ajou University. Accessed February 28, 2021. http://repository.ajou.ac.kr/handle/201003/19265 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000030197.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

정, 현주. “Effect of Tissue Transglutaminase on Steroid Resistance in T-Cell Acute Lymphoblastic Leukemia.” 2020. Web. 28 Feb 2021.

Vancouver:

정 �. Effect of Tissue Transglutaminase on Steroid Resistance in T-Cell Acute Lymphoblastic Leukemia. [Internet] [Thesis]. Ajou University; 2020. [cited 2021 Feb 28]. Available from: http://repository.ajou.ac.kr/handle/201003/19265 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000030197.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

정 �. Effect of Tissue Transglutaminase on Steroid Resistance in T-Cell Acute Lymphoblastic Leukemia. [Thesis]. Ajou University; 2020. Available from: http://repository.ajou.ac.kr/handle/201003/19265 ; http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000030197

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Duke University

27. Liu, Tingyu. Examining Glucose Metabolism in Survival and Proliferation of B Cell Derived Leukemia .

Degree: 2014, Duke University

URL: http://hdl.handle.net/10161/9410

► It has been long known that many types of cancers have high metabolic requirements and use reprogrammed metabolism to support cellular activities. The first… (more)

▼ It has been long known that many types of cancers have high metabolic requirements and use reprogrammed metabolism to support cellular activities. The first identified metabolic alteration in cancer cells was elevated glucose uptake, glycolysis activity and lactate production even in the presence of oxygen. This metabolic program, termed aerobic glycolysis or the Warburg effect, provides cells with energy as well as biosynthetic substrates to sustain cell survival and rapid cell proliferation. Cancer metabolism is closely linked to genetic mutations and oncogenic signaling pathways, such as PI3K/Akt, cMyc and HIF pathways. These oncogenic signals can direct metabolic reprogramming while changes in metabolic status can regulate activities of these signaling pathways in turn. In addition to glucose, later studies also found utilization of alternate nutrients in cancer cells, including glutamine and lipids. Glutamine is the second major metabolic fuel and can be converted to various substrates to support cell bioenergetics needs and biosynthetic reactions. Usage of metabolic fuels in cancer cells, however, is variable. While certain cancers display addiction to one type of nutrient, others are capable of using multiple nutrients. The unique metabolic features of cancer cells raise the possibility of targeting metabolism as a novel therapeutic approach for cancer treatment. Using pharmacological inhibitors, previous research has provided corroborating evidence that metabolic stress can impact survival and growth of proliferative cancer cells by regulating cell apoptotic machinery and cell cycle checkpoints. Due to lack of genetic tools and side effects from these inhibitors, however, mechanistic understanding of cell response to metabolic inhibition was limited in these studies. More importantly, how metabolic stress affects cancer progression in a physiological condition has not yet been well investigated. Lastly, current research has not examined metabolic program in indolent cancers and the metabolic requirements and activities in less proliferative cells also remain to be understood. This work examines nutrients utilization in B cell derived acute and chronic leukemia (B-ALL and B-CLL). B-ALL is an aggressive form of leukemia. Using cell lines and primary patient samples, we found B-ALL cells primarily used glucose through aerobic glycolysis, similar to other proliferative cancer cells. B-ALL cells were also more sensitive to inhibition of glycolysis than normal B cells. Employing an untargeted metabolomics profiling in combination with isotope labeled glucose tracing approach, we show in a B-ALL model that genetic ablation of glucose transporter Glut1 partially reduced glucose uptake, sufficiently hindered anabolic pathways and promoted catabolic metabolism. This metabolic shift led to sharply curtailed B-ALL proliferation in vitro and reduced leukemic burden in vivo. Furthermore, this partial inhibition of glucose metabolism sensitized B-ALL cells to apoptotic stimuli and non-cytotoxic metabolic… Advisors/Committee Members: Rathmell, Jeffrey C (advisor).

Subjects/Keywords: Pharmacology; Acute lymphoblastic leukemia; Bcl-2 family proteins; Chronic lymphocytic leukemia; Glucose metabolism

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APA (6^th Edition):

Liu, T. (2014). Examining Glucose Metabolism in Survival and Proliferation of B Cell Derived Leukemia . (Thesis). Duke University. Retrieved from http://hdl.handle.net/10161/9410

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Liu, Tingyu. “Examining Glucose Metabolism in Survival and Proliferation of B Cell Derived Leukemia .” 2014. Thesis, Duke University. Accessed February 28, 2021. http://hdl.handle.net/10161/9410.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Liu, Tingyu. “Examining Glucose Metabolism in Survival and Proliferation of B Cell Derived Leukemia .” 2014. Web. 28 Feb 2021.

Vancouver:

Liu T. Examining Glucose Metabolism in Survival and Proliferation of B Cell Derived Leukemia . [Internet] [Thesis]. Duke University; 2014. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10161/9410.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Liu T. Examining Glucose Metabolism in Survival and Proliferation of B Cell Derived Leukemia . [Thesis]. Duke University; 2014. Available from: http://hdl.handle.net/10161/9410

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

28. Shorey, Lyndsey E. Chemopreventative and chemotherapeutic properties of whole cruciferous vegetables and phytochemical components in acute T-cell lymphoblastic leukemia/lymphoma.

Degree: PhD, Toxicology, 2012, Oregon State University

URL: http://hdl.handle.net/1957/30107

► Acute lymphoblastic leukemia (ALL) encompasses a spectrum of lymphoid progenitors that have undergone malignant transformation and clonal proliferation at various stages of differentiation. Some cases… (more)

▼ Acute lymphoblastic leukemia (ALL) encompasses a spectrum of lymphoid progenitors that have undergone malignant transformation and clonal proliferation at various stages of differentiation. Some cases of ALL have been documented to have prenatal origins and in particular neonatal exposure to various environmental pollutants is associated with increased disease risk, including childhood lymphoma and leukemia. Dibenzo[def,p]chrysene (DBC) is a polycyclic aromatic hydrocarbon (PAH) and in our laboratory has been established as a transplacental carcinogen in mice, producing aggressive T-cell lymphoblastic lymphomas, lung, liver, uterine, ovarian, and testicular lesions, depending on timing and dose of exposure. Investigation of the transplacental and translactational transfer of DBC was warranted following a cross-foster experiment demonstrating the greatest tumorigenic response occurred in offspring both gestating in and nursed by an exposed female. [¹⁴C]-DBC (GD17) dosing was utilized to examine time-dependent alterations of [¹⁴C] in maternal and fetal tissues, excreta, and residual levels at weaning. Fetal tissue levels of [¹⁴C]-DBC equivalents were 10-fold lower than maternal tissue, and after weaning the residual body burden was roughly equivalent in offspring exposed only in utero or only via lactation. Certain bioactive food components, including indole-3-carbinol (I3C), 3,3'-diindolylmethane (DIM), and sulforaphane (SFN) from cruciferous vegetables have been shown to target cellular pathways regulating carcinogenesis. In the above mentioned DBC initiated model of carcinogenesis, I3C is an effective transplacental chemopreventive agent. We sought to extend our chemoprevention studies in mice to a human neoplasm in cell culture, analogous to the observed murine T-cell lymphomas. Treatment of the human T-ALL cell line CCRF-CEM (CEM) with I3C reduced cell proliferation and viability only at supraphysiologic concentrations whereas DIM, the primary acid condensation product of I3C, had a marked effect at low micromolar concentrations in vitro and reduced growth of CEM xenografts in vivo. Additional T-ALL lines, selected to represent the heterogeneity of the disease, (CCRF-HSB2, Jurkat, and SUP-T1) responded similarly in vitro, demonstrating a potential therapeutic value of DIM in T-ALL. Given that epigenetic reprograming is especially active during fetal development and that DNA hypermethylation contributes to the etiology of T-ALL we examined genome-wide DNA methylation in CEM. Differential methylation analysis revealed that DIM and I3C alter CpG methylation in unique, yet overlapping, gene targets. DIM treated cells exhibited a dose-dependent decrease in hypermethylation, an observation consistent with an epigenetic mechanism of cancer suppression. Pyroseqencing and RTPCR technologies were utilized to validate changes in DNA methylation and to compare these patterns with a transcriptional response in both novel targets and candidate genes selected from the literature. Collectively, these studies merited returning… Advisors/Committee Members: Williams, David (advisor), Ho, Emily (committee member).

Subjects/Keywords: Acute lymphoblastic leukemia; Lymphoblastic leukemia – Chemoprevention

…acute lymphoblastic leukemia/lymphoma (T-ALL) and polycyclic aromatic hydrocarbons… …childhood cancer including acute lymphoblastic leukemia/lymphoma (ALL) [reviewed in… …T-cell acute lymphoblastic leukemia/lymphoma (T-ALL) and polycyclic aromatic… …age [35]. Acute lymphoblastic leukemia/lymphoma, a heterogeneous disease of… …lymphoblastic leukemia cells ..................................... 42 3.1 Abstract…

10 more images…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Shorey, L. E. (2012). Chemopreventative and chemotherapeutic properties of whole cruciferous vegetables and phytochemical components in acute T-cell lymphoblastic leukemia/lymphoma. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/30107

Chicago Manual of Style (16^th Edition):

Shorey, Lyndsey E. “Chemopreventative and chemotherapeutic properties of whole cruciferous vegetables and phytochemical components in acute T-cell lymphoblastic leukemia/lymphoma.” 2012. Doctoral Dissertation, Oregon State University. Accessed February 28, 2021. http://hdl.handle.net/1957/30107.

MLA Handbook (7^th Edition):

Shorey, Lyndsey E. “Chemopreventative and chemotherapeutic properties of whole cruciferous vegetables and phytochemical components in acute T-cell lymphoblastic leukemia/lymphoma.” 2012. Web. 28 Feb 2021.

Vancouver:

Shorey LE. Chemopreventative and chemotherapeutic properties of whole cruciferous vegetables and phytochemical components in acute T-cell lymphoblastic leukemia/lymphoma. [Internet] [Doctoral dissertation]. Oregon State University; 2012. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1957/30107.

Council of Science Editors:

Shorey LE. Chemopreventative and chemotherapeutic properties of whole cruciferous vegetables and phytochemical components in acute T-cell lymphoblastic leukemia/lymphoma. [Doctoral Dissertation]. Oregon State University; 2012. Available from: http://hdl.handle.net/1957/30107

University of New South Wales

29. Anande, Govardhan. Investigating the significance of alternative splicing in hematological malignancies.

Degree: Prince of Wales Clinical School, 2019, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/69720

► Somatic mutations in RNA splicing genes are frequent in many haematological malignancies, but are rarer in acute myeloid leukaemia (AML). However, their roles in leukaemogenesis… (more)

▼ Somatic mutations in RNA splicing genes are frequent in many haematological malignancies, but are rarer in acute myeloid leukaemia (AML). However, their roles in leukaemogenesis are poorly described. To gain insights into the functional impact of alternative RNA splicing in leukemia, I investigated the transcriptomes of patients with matching clinical data.As a first step, I developed a bioinformatics pipeline (henceforth SpliceGX) to quantify alternative splicing (AS) and differentially expressed genes (DEGs) within the same samples. I also developed tools to predict the functional impact of AS on the translated proteins. I then applied SpliceGX to interrogate the role AS in disease severity in AML. I then applied SpliceGX in two additional, novel contexts: to study T-cell Acute Lymphoblastic Leukaemia (T-ALL) as well as in T cell development.To investigate alternative RNA splicing in AML, I extracted transcriptomic data from two published cohorts; The Cancer Genome Atlas and Clinseq. I identified 222 AS events that were significantly enriched or depleted in adverse- vs. favourable-risk AML patients with ~ 30% resulting in predicted loss of an annotated protein domain. Most AS events resulted in skipped exons with dysregulation of mTOR and integrin signalling in patients assigned as adverse risk by the European Leukaemia Net (ELN). Motif analysis of alternatively spliced junctions showed usage of non-canonical splice sites. Integrating AS with DEG in adverse- vs. favourable-risk AML further showed that aberrant splicing, even in the absence of known splicing factor mutations, triggers a stress response and the up-regulation of inflammatory genes in AML patients with poor prognosis. Furthermore, using machine learning, I discovered four alternatively spliced transcripts of prognostic significance in AML.Using SpliceGX, I identified characteristic splicing signatures at each waypoint during healthy T cell development, which affected various pathways responsible for cell growth, differentiation, and lineage commitment of thymocytes. In T-ALL, I discovered aberrant splicing of leukaemia driver and splicing factor genes, which indicate that in T-ALL deregulation of cancer genes occurs primarily at the level of splicing, rather than via somatic mutations.In summary, I have developed a bioinformatics pipeline and surveyed RNA splicing in AML and healthy T cell/T-ALL and identified specific events of interest that could be of value as therapeutic targets. Advisors/Committee Members: Unnikrishnan, Ashwin, Prince of Wales Clinical School, Faculty of Medicine, UNSW, Pimanda, John, Prince of Wales Clinical School, Faculty of Medicine, UNSW, Wong, Jason, Prince of Wales Clinical School, Faculty of Medicine, UNSW, Deshpande, Nandan, Biotechnology & Biomolecular Sciences, Faculty of Science, UNSW.

Subjects/Keywords: Leukemia; Acute myeloid leukaemia; Alternative splicing; RNA sequencing; T-cell Acute Lymphoblastic Leukaemia

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APA (6^th Edition):

Anande, G. (2019). Investigating the significance of alternative splicing in hematological malignancies. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/69720

Chicago Manual of Style (16^th Edition):

Anande, Govardhan. “Investigating the significance of alternative splicing in hematological malignancies.” 2019. Doctoral Dissertation, University of New South Wales. Accessed February 28, 2021. http://handle.unsw.edu.au/1959.4/69720.

MLA Handbook (7^th Edition):

Anande, Govardhan. “Investigating the significance of alternative splicing in hematological malignancies.” 2019. Web. 28 Feb 2021.

Vancouver:

Anande G. Investigating the significance of alternative splicing in hematological malignancies. [Internet] [Doctoral dissertation]. University of New South Wales; 2019. [cited 2021 Feb 28]. Available from: http://handle.unsw.edu.au/1959.4/69720.

Council of Science Editors:

Anande G. Investigating the significance of alternative splicing in hematological malignancies. [Doctoral Dissertation]. University of New South Wales; 2019. Available from: http://handle.unsw.edu.au/1959.4/69720

30. Moreno, Daniel Antunes. Estudo da expressão dos genes de classe I das histonas desacetilases (HDACs 1,2,3 e 8) em Leucemia Linfóide Aguda de crianças e adolescentes.

Degree: Mestrado, Genética, 2008, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/17/17135/tde-07052009-120246/ ;

►

A Leucemia Linfóide Aguda (LLA) é uma doença heterogênea em relação à biologia e ao prognóstico. Além de alterações genéticas, anormalidades epigenéticas, estão estreitamente relacionadas… (more)

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A Leucemia Linfóide Aguda (LLA) é uma doença heterogênea em relação à biologia e ao prognóstico. Além de alterações genéticas, anormalidades epigenéticas, estão estreitamente relacionadas ao processo de carcinogênese e entre os mecanismos epigenéticos, a acetilação das histonas é um componente essencial para a regulação da estrutura da cromatina e atividade transcricional. Esse processo é mediado pelas histonas acetiltransferases (HATs). Por outro lado, a desacetilação, por meio das histonas desacetilases (HDACs), está relacionada à condensação da cromatina e repressão transcricional. A expressão anormal das HDACs tem sido associada ao processo de leucemogênese, revelando ser uma área promissora na caracterização de grupos de risco e tratamento do câncer. Os objetivos deste trabalho foram avaliar a expressão dos genes da classe I de HDACs (HDAC 1, 2, 3 e 8), correlacionar os resultados com as características clínicas e de prognóstico (idade, gênero, grupo de risco, contagem inicial de blastos, imunofenótipo, resposta ao tratamento, doença residual mínima nos dias 14 e 18 e a sobrevida livre de eventos) em 46 amostras consecutivas de medula óssea de crianças e adolescentes portadores de LLA; comparar e correlacionar a expressão dos genes estudados entre as amostras de pacientes portadores LLA e 10 amostras de medula óssea sem doença hematológica. A análise da expressão gênica foi realizada através da técnica de PCR em Tempo Real pelo método TaqMan®. Foi observado um aumento da expressão do gene HDAC1 nas amostras dos pacientes bons respondedores ao ix tratamento. O gene HDAC2 foi mais expresso no grupo de pacientes do gênero masculino (p=0,038). Esse gene também mostrou uma expressão aumentada nos pacientes de alto risco (p=0,060) e com sobrevida menor (p=0,065), entretanto os valores encontrados não foram estatisticamente significativos. Além disso, foi observada uma expressão aumentada dos genes HDAC2 (p=0,007), HDAC3 (p=0,014) e HDAC8 (p=0,002) em amostras de pacientes com LLA quando comparadas às amostras de medula óssea sem doença hematológica. Houve correlação entre a expressão de todos os genes de classe I das HDACs, exceto entre HDAC1 e HDAC8. Os resultados obtidos nesse trabalho sugerem que as HDACs de classe I, podem representar importantes alvos para futuros estudos em LLA, no entanto são necessários de testes funcionais para confirmar estes resultados.

Acute Lymphoblastic Leukemia (ALL) is a heterogeneous disease with distinct biologic and prognostic groups. In addition to genetic alterations, epigenetic processes play an important role in carcinogenesis, among which histone acetylation/deacetylation is crucial for chromatin modulation structure and transcriptional activity. Histone acetylation is regulated by the enzyme histone acetyl transferases (HATs). On the other hand, the deacetylation process is regulated by histone deacetylases (HDACs) enzymes, which is associated with the chromatin condensation and transcriptional repression. Abnormal expression of HDACs is a common feature of cancer and has…

Advisors/Committee Members: Tone, Luiz Gonzaga.

Subjects/Keywords: Acetilação; Acetylation; Acute Lymphoblastic Leukemia; Childhood; Criança; Histonas Desacetilases; Histones Deacetylases; Leucemia Linfóide Aguda

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APA (6^th Edition):

Moreno, D. A. (2008). Estudo da expressão dos genes de classe I das histonas desacetilases (HDACs 1,2,3 e 8) em Leucemia Linfóide Aguda de crianças e adolescentes. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/17/17135/tde-07052009-120246/ ;

Chicago Manual of Style (16^th Edition):

Moreno, Daniel Antunes. “Estudo da expressão dos genes de classe I das histonas desacetilases (HDACs 1,2,3 e 8) em Leucemia Linfóide Aguda de crianças e adolescentes.” 2008. Masters Thesis, University of São Paulo. Accessed February 28, 2021. http://www.teses.usp.br/teses/disponiveis/17/17135/tde-07052009-120246/ ;.

MLA Handbook (7^th Edition):

Moreno, Daniel Antunes. “Estudo da expressão dos genes de classe I das histonas desacetilases (HDACs 1,2,3 e 8) em Leucemia Linfóide Aguda de crianças e adolescentes.” 2008. Web. 28 Feb 2021.

Vancouver:

Moreno DA. Estudo da expressão dos genes de classe I das histonas desacetilases (HDACs 1,2,3 e 8) em Leucemia Linfóide Aguda de crianças e adolescentes. [Internet] [Masters thesis]. University of São Paulo; 2008. [cited 2021 Feb 28]. Available from: http://www.teses.usp.br/teses/disponiveis/17/17135/tde-07052009-120246/ ;.

Council of Science Editors:

Moreno DA. Estudo da expressão dos genes de classe I das histonas desacetilases (HDACs 1,2,3 e 8) em Leucemia Linfóide Aguda de crianças e adolescentes. [Masters Thesis]. University of São Paulo; 2008. Available from: http://www.teses.usp.br/teses/disponiveis/17/17135/tde-07052009-120246/ ;

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