subject:(acute kidney injury)

University of Manitoba

1. Choi, Nora. Study of iron pathophysiology for early diagnosis of acute kidney injury secondary to ischemia reperfusion injury following cardiopulmonary bypass.

Degree: Immunology, 2017, University of Manitoba

URL: http://hdl.handle.net/1993/32763

► Currently, there are no successful therapies proven to ameliorate acute kidney injury (AKI). AKI secondary to ischemia reperfusion injury (IRI) leads to increased morbidity and… (more)

Subjects/Keywords: Acute kidney injury

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APA (6^th Edition):

Choi, N. (2017). Study of iron pathophysiology for early diagnosis of acute kidney injury secondary to ischemia reperfusion injury following cardiopulmonary bypass. (Masters Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/32763

Chicago Manual of Style (16^th Edition):

Choi, Nora. “Study of iron pathophysiology for early diagnosis of acute kidney injury secondary to ischemia reperfusion injury following cardiopulmonary bypass.” 2017. Masters Thesis, University of Manitoba. Accessed April 13, 2021. http://hdl.handle.net/1993/32763.

MLA Handbook (7^th Edition):

Choi, Nora. “Study of iron pathophysiology for early diagnosis of acute kidney injury secondary to ischemia reperfusion injury following cardiopulmonary bypass.” 2017. Web. 13 Apr 2021.

Vancouver:

Choi N. Study of iron pathophysiology for early diagnosis of acute kidney injury secondary to ischemia reperfusion injury following cardiopulmonary bypass. [Internet] [Masters thesis]. University of Manitoba; 2017. [cited 2021 Apr 13]. Available from: http://hdl.handle.net/1993/32763.

Council of Science Editors:

Choi N. Study of iron pathophysiology for early diagnosis of acute kidney injury secondary to ischemia reperfusion injury following cardiopulmonary bypass. [Masters Thesis]. University of Manitoba; 2017. Available from: http://hdl.handle.net/1993/32763

University of Otago

2. Nejat, Maryam. Biomarkers in early diagnosis of acute kidney injury .

Degree: 2011, University of Otago

URL: http://hdl.handle.net/10523/1915

► Acute Kidney injury (AKI) is common and frequently fatal. Delay in plasma creatinine based diagnosis of AKI has compromised clinical trials of experimentally promising therapies… (more)

▼ Acute Kidney injury (AKI) is common and frequently fatal. Delay in plasma creatinine based diagnosis of AKI has compromised clinical trials of experimentally promising therapies of kidney injury. Therefore, a number of potential early urinary and plasma biomarkers of renal cell injury have been evaluated in several clinical and experimental studies. However, many uncertainties remain in the diagnostic and predictive capability of these biomarkers in various forms of AKI, especially in heterogeneous population. The overall aim in this project was to analyse the diagnostic and predictive performance of some novel AKI biomarkers in a heterogeneous high-risk population. This project focused on the performance of plasma and urinary cystatin C (CysC) as markers of kidney function and injury respectively and both as predictors of mortality. This involved separate analysis of plasma and urinary CysC clinical data, and an experimental study investigating the performance of urinary CysC in the presence of albuminuria. Finally, the ability of fractional urinary biomarkers (fractional excretion of sodium (FENa) and urea (FEurea) to distinguish between so-called pre-renal AKI and established AKI was assessed. Clinical data came from the EARLYARF study, which was initiated by Professor Zoltan Endre prior to commencement of my PhD project. I participated in data collection and data entry for the large part of this study and I was provided access to the database to address the objectives of my thesis. The hypotheses were explored by analysing data arising from this study. The experimental study of the effect of proteinuria and albuminuria on urinary CysC arose from the observation of cystatinuria in children with proteinuria. This was explored in an animal model of transient albuminuria, which I developed. Plasma CysC has been proposed as an alternative to plasma creatinine as a measure of renal function. In Chapter 3, relative changes of plasma CysC and plasma creatinine were compared in critically ill patients. I was able to demonstrate that plasma CysC generally increased prior to plasma creatinine. Plasma CysC and creatinine were similarly moderately predictive of death or the need for dialysis. Plasma CysC was a more effective and earlier surrogate marker of decreased renal function than plasma creatinine in a general intensive care unit population. In Chapter 4, the utility of urinary CysC as a diagnostic marker of AKI, and predictor of mortality in critically ill patients was evaluated. Urinary CysC was diagnostic of and predictive of death. Unexpectedly, it was also found to be diagnostic of sepsis. Concentrations of urinary CysC were significantly higher in the presence of sepsis (p<0.0001) or AKI (p<0.0001). There was no interaction between sepsis and AKI on the urinary CysC concentrations (p=0.53). Urinary CysC was independently associated with AKI, sepsis, and death within 30 days. Low molecular weight (LMW) proteins, including albumin and novel urinary biomarkers of AKI such as CysC and neutrophil… Advisors/Committee Members: Endre, Zoltan Huba (advisor).

Subjects/Keywords: Acute kidney injury; Biomarkers

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APA (6^th Edition):

Nejat, M. (2011). Biomarkers in early diagnosis of acute kidney injury . (Doctoral Dissertation). University of Otago. Retrieved from http://hdl.handle.net/10523/1915

Chicago Manual of Style (16^th Edition):

Nejat, Maryam. “Biomarkers in early diagnosis of acute kidney injury .” 2011. Doctoral Dissertation, University of Otago. Accessed April 13, 2021. http://hdl.handle.net/10523/1915.

MLA Handbook (7^th Edition):

Nejat, Maryam. “Biomarkers in early diagnosis of acute kidney injury .” 2011. Web. 13 Apr 2021.

Vancouver:

Nejat M. Biomarkers in early diagnosis of acute kidney injury . [Internet] [Doctoral dissertation]. University of Otago; 2011. [cited 2021 Apr 13]. Available from: http://hdl.handle.net/10523/1915.

Council of Science Editors:

Nejat M. Biomarkers in early diagnosis of acute kidney injury . [Doctoral Dissertation]. University of Otago; 2011. Available from: http://hdl.handle.net/10523/1915

University of Toronto

3. Harel, Ziv. Association Between Early Follow-up with a Nephrologist and Death in Survivors of Acute Kidney Injury.

Degree: 2012, University of Toronto

URL: http://hdl.handle.net/1807/32466

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Background: Survivors of severe acute kidney injury remain at high risk of death well-after apparent recovery from the initial event. Methods: We conducted a cohort… (more)

Subjects/Keywords: acute kidney injury; 0766

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APA (6^th Edition):

Harel, Z. (2012). Association Between Early Follow-up with a Nephrologist and Death in Survivors of Acute Kidney Injury. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/32466

Chicago Manual of Style (16^th Edition):

Harel, Ziv. “Association Between Early Follow-up with a Nephrologist and Death in Survivors of Acute Kidney Injury.” 2012. Masters Thesis, University of Toronto. Accessed April 13, 2021. http://hdl.handle.net/1807/32466.

MLA Handbook (7^th Edition):

Harel, Ziv. “Association Between Early Follow-up with a Nephrologist and Death in Survivors of Acute Kidney Injury.” 2012. Web. 13 Apr 2021.

Vancouver:

Harel Z. Association Between Early Follow-up with a Nephrologist and Death in Survivors of Acute Kidney Injury. [Internet] [Masters thesis]. University of Toronto; 2012. [cited 2021 Apr 13]. Available from: http://hdl.handle.net/1807/32466.

Council of Science Editors:

Harel Z. Association Between Early Follow-up with a Nephrologist and Death in Survivors of Acute Kidney Injury. [Masters Thesis]. University of Toronto; 2012. Available from: http://hdl.handle.net/1807/32466

University of Minnesota

4. Leither, Maxwell. Outpatient Acute Kidney Injury Increases Risk of Mortality and Chronic Kidney Disease.

Degree: MS, Clinical Research, 2017, University of Minnesota

URL: http://hdl.handle.net/11299/198958

► Introduction: Limited data exist regarding outcomes of patients with outpatient acute kidney injury (AKI). To determine whether outpatient AKI is associated with increased mortality and… (more)

Subjects/Keywords: acute kidney injury; chronic kidney disease; nephrology

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APA (6^th Edition):

Leither, M. (2017). Outpatient Acute Kidney Injury Increases Risk of Mortality and Chronic Kidney Disease. (Masters Thesis). University of Minnesota. Retrieved from http://hdl.handle.net/11299/198958

Chicago Manual of Style (16^th Edition):

Leither, Maxwell. “Outpatient Acute Kidney Injury Increases Risk of Mortality and Chronic Kidney Disease.” 2017. Masters Thesis, University of Minnesota. Accessed April 13, 2021. http://hdl.handle.net/11299/198958.

MLA Handbook (7^th Edition):

Leither, Maxwell. “Outpatient Acute Kidney Injury Increases Risk of Mortality and Chronic Kidney Disease.” 2017. Web. 13 Apr 2021.

Vancouver:

Leither M. Outpatient Acute Kidney Injury Increases Risk of Mortality and Chronic Kidney Disease. [Internet] [Masters thesis]. University of Minnesota; 2017. [cited 2021 Apr 13]. Available from: http://hdl.handle.net/11299/198958.

Council of Science Editors:

Leither M. Outpatient Acute Kidney Injury Increases Risk of Mortality and Chronic Kidney Disease. [Masters Thesis]. University of Minnesota; 2017. Available from: http://hdl.handle.net/11299/198958

University of Toronto

5. Chaturvedi, Swasti. SLIT2 Prevents Renal Ischemia Reperfusion Injury in Mice.

Degree: 2012, University of Toronto

URL: http://hdl.handle.net/1807/42902

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The Slit family of secreted proteins act as axonal repellents during embryogenesis. Slit2 via its receptor, Roundabout-1, also inhibits chemotaxis of multiple leukocyte subsets. Using… (more)

Subjects/Keywords: acute kidney injury; ischaemia-reperfusion injury; 0379

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chaturvedi, S. (2012). SLIT2 Prevents Renal Ischemia Reperfusion Injury in Mice. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/42902

Chicago Manual of Style (16^th Edition):

Chaturvedi, Swasti. “SLIT2 Prevents Renal Ischemia Reperfusion Injury in Mice.” 2012. Masters Thesis, University of Toronto. Accessed April 13, 2021. http://hdl.handle.net/1807/42902.

MLA Handbook (7^th Edition):

Chaturvedi, Swasti. “SLIT2 Prevents Renal Ischemia Reperfusion Injury in Mice.” 2012. Web. 13 Apr 2021.

Vancouver:

Chaturvedi S. SLIT2 Prevents Renal Ischemia Reperfusion Injury in Mice. [Internet] [Masters thesis]. University of Toronto; 2012. [cited 2021 Apr 13]. Available from: http://hdl.handle.net/1807/42902.

Council of Science Editors:

Chaturvedi S. SLIT2 Prevents Renal Ischemia Reperfusion Injury in Mice. [Masters Thesis]. University of Toronto; 2012. Available from: http://hdl.handle.net/1807/42902

University of Notre Dame

6. Kristen Koenig McCampbell. Nephron regeneration after acute kidney injury in the zebrafish</h1>.

Degree: Biological Sciences, 2013, University of Notre Dame

URL: https://curate.nd.edu/show/q811kh06s21

► Acute kidney injury (AKI) is a devastating and often lethal condition in which kidney nephron cells are destroyed by damage from ischemia or toxin… (more)

▼ Acute kidney injury (AKI) is a devastating and often lethal condition in which kidney nephron cells are destroyed by damage from ischemia or toxin exposure. Interestingly, there is evidence that suggests nephron epithelial cells can regenerate after some forms of damage, but there is a poor understanding of the cellular and molecular events that mediate nephron regeneration. The zebrafish is an attractive and viable system to study the molecular pathways responsible for nephron regeneration, as its nephrons are simple, yet they maintain the biological complexity inherent to that of higher organisms including mammals. Previous studies have demonstrated that gentamicin-based chemical injury in zebrafish mimics human AKI, but detailed analysis of the cellular events associated with damage was not reported. We generated a novel toolkit of cellular and molecular protocols to perform this analysis in the zebrafish. We explored the feasibility of AKI studies in the zebrafish embryo, and identified basic aspects of the injury process. Next, we extensively characterized the cellular changes resulting from gentamicin injury in the adult zebrafish using our platform of histology and immunohistochemistry techniques. This work has established the timing of renal cell death after injury, identified proliferative compartments within the kidney, and led to the assessment of gene expression changes associated with the regenerative response of proliferating cells. Taken together, this dissertation project has provided a greater understanding of the full cycle of regenerative events. Insights from this work can be applied in future studies toward the design of chemical genetics screens in the adult and/or embryonic zebrafish to identify renal regeneration pathways and provide novel insights into the signals that orchestrate kidney epithelial regeneration. Advisors/Committee Members: Dr. John G. Duman, Committee Member, Dr. Zachary T. Schafer, Committee Member, Dr. Rebecca A. Wingert, Committee Chair.

Subjects/Keywords: tubular injury; regeneration; acute kidney injury; kidney; repair; zebrafish

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APA (6^th Edition):

McCampbell, K. K. (2013). Nephron regeneration after acute kidney injury in the zebrafish</h1>. (Thesis). University of Notre Dame. Retrieved from https://curate.nd.edu/show/q811kh06s21

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

McCampbell, Kristen Koenig. “Nephron regeneration after acute kidney injury in the zebrafish</h1>.” 2013. Thesis, University of Notre Dame. Accessed April 13, 2021. https://curate.nd.edu/show/q811kh06s21.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

McCampbell, Kristen Koenig. “Nephron regeneration after acute kidney injury in the zebrafish</h1>.” 2013. Web. 13 Apr 2021.

Vancouver:

McCampbell KK. Nephron regeneration after acute kidney injury in the zebrafish</h1>. [Internet] [Thesis]. University of Notre Dame; 2013. [cited 2021 Apr 13]. Available from: https://curate.nd.edu/show/q811kh06s21.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

McCampbell KK. Nephron regeneration after acute kidney injury in the zebrafish</h1>. [Thesis]. University of Notre Dame; 2013. Available from: https://curate.nd.edu/show/q811kh06s21

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Melbourne

7. Roberts, Veena. Therapeutic potential of the adenosinergic pathway in acute and chronic kidney disease following ischaemia reperfusion injury.

Degree: 2016, University of Melbourne

URL: http://hdl.handle.net/11343/108552

► The incidence of chronic kidney disease (CKD) is rising and the consequences of CKD include premature mortality and progression to end stage kidney disease. Renal… (more)

▼ The incidence of chronic kidney disease (CKD) is rising and the consequences of CKD include premature mortality and progression to end stage kidney disease. Renal ischaemia reperfusion injury (IRI) occurring in clinical settings leads to acute kidney injury (AKI) that predisposes to the development of CKD. The hallmark lesion in CKD is renal fibrosis and clinically there is no direct anti-fibrotic therapy available to halt or reverse the development of renal fibrosis. The adenosinergic pathway is activated during renal IRI and the enzyme CD39 is involved in the generation of adenosine, which has been demonstrated to be protective in the acute phase of IRI. This thesis explores the potential of CD39 (either overexpression of a CD39 transgene or administration of soluble apyrase) and the adenosine A2B receptor (A2BR) as therapeutic targets in the reduction of renal fibrosis that develops after the acute phase of IRI. Using mouse models of renal IRI, it was demonstrated that a transient increase in CD39 activity before IRI, by administration of the enzyme apyrase, effectively reduced AKI and renal fibrosis. However, continuously elevated CD39 activity, achieved by overexpression of the human CD39 transgene (CD39Tg), protected against AKI but led to increased renal adenosine content and increased renal fibrosis. Renal fibrosis following IRI was also shown to be associated with increased A2BR mRNA expression in the kidney, and the role of the A2BR in renal fibrosis was examined by administration of a specific A2BR inhibitor. Inhibition of the A2BR following IRI significantly down-regulated a number of signalling molecules that contribute to fibrosis, although no change in fibrosis was demonstrable. While increased adenosine and A2BR activity protect from acute IRI, these studies show that a sustained increase in adenosine levels and increased A2BR expression after IRI promote renal fibrosis. This suggests a dual role for adenosine and the A2BR in renal injury following IRI, which has not previously been recognised. Finally, in a model of unilateral ureteric obstruction (UUO), CD39Tg mice developed a similar extent of fibrosis to that of WT littermates, in contrast to the increased renal fibrosis seen in CD39Tg mice after IRI. These findings indicate that different mechanisms of injury affect different pathways in the development of renal fibrosis. In conclusion, the studies described in this thesis demonstrate that soluble apyrase and A2BR inhibition are potential therapeutic tools to reduce the development of renal fibrosis following IRI. This thesis also highlights the need to identify and understand the multiple pathways involved in the development of renal fibrosis and the possibility that combination therapies will be more effective than single agents in the treatment and prevention of CKD following IRI.

Subjects/Keywords: adenosine; ischaemia reperfusion injury; acute kidney injury; chronic kidney disease

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APA (6^th Edition):

Roberts, V. (2016). Therapeutic potential of the adenosinergic pathway in acute and chronic kidney disease following ischaemia reperfusion injury. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/108552

Chicago Manual of Style (16^th Edition):

Roberts, Veena. “Therapeutic potential of the adenosinergic pathway in acute and chronic kidney disease following ischaemia reperfusion injury.” 2016. Doctoral Dissertation, University of Melbourne. Accessed April 13, 2021. http://hdl.handle.net/11343/108552.

MLA Handbook (7^th Edition):

Roberts, Veena. “Therapeutic potential of the adenosinergic pathway in acute and chronic kidney disease following ischaemia reperfusion injury.” 2016. Web. 13 Apr 2021.

Vancouver:

Roberts V. Therapeutic potential of the adenosinergic pathway in acute and chronic kidney disease following ischaemia reperfusion injury. [Internet] [Doctoral dissertation]. University of Melbourne; 2016. [cited 2021 Apr 13]. Available from: http://hdl.handle.net/11343/108552.

Council of Science Editors:

Roberts V. Therapeutic potential of the adenosinergic pathway in acute and chronic kidney disease following ischaemia reperfusion injury. [Doctoral Dissertation]. University of Melbourne; 2016. Available from: http://hdl.handle.net/11343/108552

8. Karathanasis, Dimitrios. Οξεία νεφρική βλάβη μετά από καρδιοχειρουργική επέμβαση: διαγνωστική αξία βιοδεικτών.

Degree: 2019, University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας

URL: http://hdl.handle.net/10442/hedi/46038

►

Background: Cardiac Surgery Associated Acute Kidney Injury (CSA-AKI) is one of the most serious complications of heart surgery. The fact of the known time of… (more)

▼

Background: Cardiac Surgery Associated Acute Kidney Injury (CSA-AKI) is one of the most serious complications of heart surgery. The fact of the known time of an elective cardiac surgery makes it an ideal model for early diagnosis and prevention of CSA-AKI. The aim of the study is to investigate the effect of hydration both on the frequency of CSA-AKI and on the biomarkers Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Kidney Injury Molecule-1 (KIM-1) by focusing on sodium bicarbonate and sodium chloride solutions. Secondary aim is to examine the diagnostic value of biomarkers in the prediction of CSA-AKI by focusing on the predictive system of Age-Creatinine-Ejection Fraction (ACEF) score, the postoperative change in serum creatinine six hours after the induction of anesthesia (ΔSCr) as well as the newer molecules NGAL and KIM-1 with the pursuit of developing an ideal prevention tool. Material and Methods: From February 2012 to October 2014, all adult patients who underwent elective, on pump artery bypass grafting and/or valve repair with a predisposition to manifest CSA-AKI were enrolled. Patients were randomized to intravenous infusion of isotonic sodium chloride or sodium bicarbonate or none of them for 24 hours. Urinary NGAL and KIM-1 were measured before the induction of anesthesia and 18 hours post-surgery. CSA-AKI was defined on the basis of the current guidelines of Kidney Disease Improving Global Outcomes (KDIGO). All statistical analyses were conducted using SPSS 24.Results: From a total of 112, finally enrolled in the study 86 patients. CSA-AKI appeared in 14 (16,3%) patients. No statistically significant correlation was observed between isotonic sodium chloride or sodium bicarbonate solution and the manifestation of CSA-AKI. Also, there was not observed any statistically significant effect of hydration with isotonic sodium chloride or sodium bicarbonate solution on biomarkers NGAL and KIM-1. ΔSCr, ACEF score, NGAL and KIM-1 as CSA-AKI biomarkers showed AUC of 0.537, 0.692, 0.575 and 0.507 respectively. NGAL and KIM-1 combination showed AUC of 0.507 while ΔSCr combinations with NGAL and KIM-1 had similarly low scores. The combinations with ACEF score showed high AUCs and especially the combination of post-operative NGAL with ACEF score had AUC of 0.768. The combination of post-operative NGAL and KIM-1 with ACEF score showed AUC of 0.788. Conclusions: Hydration with isotonic sodium bicarbonate solution or normal saline does not deter the manifestation of CSA-AKI nor does it affect the biomarkers NGAL and KIM-1. The combination of NGAL 18 hours postoperatively with ACEF score is a reliable prognostic biomarker of CSA-AKI.

Εισαγωγή: Η σχετιζόμενη με καρδιοχειρουργική επέμβαση οξεία νεφρική βλάβη (ΣΚΕ-ONB) αποτελεί μια από τις σημαντικότερες επιπλοκές των καρδιακών επεμβάσεων. Το δεδομένο του γνωστού χρόνου υλοποίησης ενός προγραμματισμένου χειρουργείου καρδιάς, το καθιστά ιδανικό μοντέλο μελέτης των μηχανισμών έγκαιρης διάγνωσης και πρόληψης της ΣΚΕ-ONB. Σκοπός της μελέτης είναι να διερευνήσει την…

Subjects/Keywords: Οξεία νεφρική βλάβη; Acute kidney injury

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APA (6^th Edition):

Karathanasis, D. (2019). Οξεία νεφρική βλάβη μετά από καρδιοχειρουργική επέμβαση: διαγνωστική αξία βιοδεικτών. (Thesis). University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας. Retrieved from http://hdl.handle.net/10442/hedi/46038

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Karathanasis, Dimitrios. “Οξεία νεφρική βλάβη μετά από καρδιοχειρουργική επέμβαση: διαγνωστική αξία βιοδεικτών.” 2019. Thesis, University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας. Accessed April 13, 2021. http://hdl.handle.net/10442/hedi/46038.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Karathanasis, Dimitrios. “Οξεία νεφρική βλάβη μετά από καρδιοχειρουργική επέμβαση: διαγνωστική αξία βιοδεικτών.” 2019. Web. 13 Apr 2021.

Vancouver:

Karathanasis D. Οξεία νεφρική βλάβη μετά από καρδιοχειρουργική επέμβαση: διαγνωστική αξία βιοδεικτών. [Internet] [Thesis]. University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας; 2019. [cited 2021 Apr 13]. Available from: http://hdl.handle.net/10442/hedi/46038.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Karathanasis D. Οξεία νεφρική βλάβη μετά από καρδιοχειρουργική επέμβαση: διαγνωστική αξία βιοδεικτών. [Thesis]. University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας; 2019. Available from: http://hdl.handle.net/10442/hedi/46038

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Cape Town

9. Mzingeli, Luvuyo. Study of epidemiology, management and outcome of acute kidney injury post noncardiac surgery over 12 months at Groote Schuur Hospital, Cape Town.

Degree: Image, Medicine, 2015, University of Cape Town

URL: http://hdl.handle.net/11427/17425

► INTRODUCTION : Acute kidney injury (AKI) is a disorder that is defined by rising serum creatinine and reduced urine output. It occurs in approximately 1-7%… (more)

▼ INTRODUCTION : Acute kidney injury (AKI) is a disorder that is defined by rising serum creatinine and reduced urine output. It occurs in approximately 1-7% of hospitalized patients and is a major predictor of morbidity and mortality. It increases the costs and duration of hospital stay. AKI has been extensively studied post cardiac surgery, but there has been little attention on AKI occurring after non cardiac surgery . There have been few studies on AKI from developing countries and a paucity of data of post non cardiac surgery AKI. OBJECTIVE : To identify which known risk factors for AKI are commonly encountered at Groote Schuur Hospital, to document 30 and 90 day mortality, length of hospital stay, recovery of renal function at 90 days and identify factors associated with outcome post non-cardiac surgery. DESIGN: Prospective observational study. SETTING: Surgical Wards and ICU. PARTICIPANTS: Patients with AKI post non-cardiac surgery admitted between July 2012 and July 2013, who were 18 years and above without underlying stage 5 chronic kidney disease. OUTCOME MEASURES: Mortality, identification of risk factors, length of hospital stay and recovery of renal function. RESULTS: Of 367 patients referred to renal unit with AKI, 60 patients met inclusion criteria. Patients had an average age of 52.8 years (standard deviation 16.6) and 70% (42/60) were male. 61.7% (37 /60) were Coloured, 20% (12/60) were White and 18.3% (11/60) were Black. These patients were exposed to the following risk factors: 80%(48/60) had emergency surgery, 66. 7%(40/60) had sepsis, 65%(39/60) had perioperative contrast exposure, 53.3%(32/60) had hypotension that required inotropic support in 50%(30/60). Mortality was 33.3% (20/60) at 30 days and 45% (27/60) at 90 days. Of the 33 patients who did not die, 81.8% (27 /33) recovered their renal function to normal baseline creatinine at 90 days. Of the 6 patients, whose renal function did not return to baseline, none required long term dialysis. Perioperative contrast exposure was associated with a longer median length of hospital stay compared to patients not exposed to contrast (21 vs 16 days respectively, p<0.05). Sepsis and age > 60 years was associated with poor recovery of renal function (p=0.005, p=0.01 respectively). No risk factor was identified to be associated with mortality. CONCLUSION: Risk factors for post non cardiac surgery AKI commonly encountered at Groote Schuur Hospital were emergency surgery, sepsis, hypotension, perioperative use of inotropes and perioperative contrast exposure. The latter was identified as a modifiable risk factor which significantly prolonged hospital stay. Sepsis and age > 60 years were associated with poorer recovery of renal function. Advisors/Committee Members: Rayner, Brian L (advisor).

Subjects/Keywords: acute kidney injury; post noncardiac surgery

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APA (6^th Edition):

Mzingeli, L. (2015). Study of epidemiology, management and outcome of acute kidney injury post noncardiac surgery over 12 months at Groote Schuur Hospital, Cape Town. (Thesis). University of Cape Town. Retrieved from http://hdl.handle.net/11427/17425

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mzingeli, Luvuyo. “Study of epidemiology, management and outcome of acute kidney injury post noncardiac surgery over 12 months at Groote Schuur Hospital, Cape Town.” 2015. Thesis, University of Cape Town. Accessed April 13, 2021. http://hdl.handle.net/11427/17425.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mzingeli, Luvuyo. “Study of epidemiology, management and outcome of acute kidney injury post noncardiac surgery over 12 months at Groote Schuur Hospital, Cape Town.” 2015. Web. 13 Apr 2021.

Vancouver:

Mzingeli L. Study of epidemiology, management and outcome of acute kidney injury post noncardiac surgery over 12 months at Groote Schuur Hospital, Cape Town. [Internet] [Thesis]. University of Cape Town; 2015. [cited 2021 Apr 13]. Available from: http://hdl.handle.net/11427/17425.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mzingeli L. Study of epidemiology, management and outcome of acute kidney injury post noncardiac surgery over 12 months at Groote Schuur Hospital, Cape Town. [Thesis]. University of Cape Town; 2015. Available from: http://hdl.handle.net/11427/17425

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of New South Wales

10. Pianta, Timothy. Biomarkers of acute kidney injury and delayed graft function. Structure, function, and the effect of treatment.

Degree: Clinical School - Prince of Wales Hospital, 2015, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/56421 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:40689/SOURCE02?view=true

► Increases in serum creatinine (sCr) and oliguria are the current functional criteria for recognising acute kidney injury (AKI) including AKI causing delayed graft function (DGF)… (more)

▼ Increases in serum creatinine (sCr) and oliguria are the current functional criteria for recognising acute kidney injury (AKI) including AKI causing delayed graft function (DGF) and slow graft function (SGF) following kidney transplantation. However, there are limitations to GFR reduction as a marker of AKI or its successful treatment. Moreover, increases in sCr or oliguria have limitations as surrogates of GFR. Alternatives for evaluation of AKI and DGF include other functional biomarkers and urinary biomarkers of kidney damage.We developed a time-dependent biomarker profile of moderate-to-severe cisplatin-induced AKI in rats, and evaluated histological injury, functional biomarkers, and kidney-damage biomarkers. Several potential interventions to ameliorate cisplatin-induced AKI were then assessed. Subsequently, kidney damage biomarkers were monitored during the functional amelioration of alpha-lipoic acid (A-LA) for treatment of cisplatin-induced-AKI, with the general aim of evaluating whether damage biomarkers could improve monitoring of intervention in AKI. The clinical use of novel functional and damage biomarkers in the diagnosis of cisplatin-induced AKI was also evaluated in an observational study. Finally, observational studies were conducted to evaluate functional biomarkers including kinetic eGFR, and kidney damage biomarkers for diagnosis of DGF or SGF. A-LA treatment ameliorated cisplatin-induced AKI in rats with protection demonstrated by reductions in structural damage, markers of loss of function, and in biomarkers of tubular damage. In the first clinical study, plasma cystatin C increased independently of other functional or damage AKI biomarkers after cisplatin-based chemotherapy, suggesting limitations to cystatin C use in this context. In a second clinical study, VEGF-A, urinary clusterin and the cell cycle arrest biomarkers TIMP-2 and IGFBP7 predicted with DGF within 4 hours of transplantation. Despite the usual limitations of sCr, early and frequent assessment of rate of change of sCr also predicted DGF: the creatinine reduction ratio predicted DGF within 12 hours, while estimates of kinetic GFR were predictive within 4 hours of renal transplantation.Despite a clear need for novel AKI biomarkers, their use and interpretation remains context-specific. These novel AKI biomarkers require robust pre-clinical data, evaluation in specific contexts, and comparison with currently available parameters before clinical use. Advisors/Committee Members: Endre, Zoltan, Clinical School - Prince of Wales Hospital, Faculty of Medicine, UNSW, Buckley, Nicholas, Clinical School - Prince of Wales Hospital, Faculty of Medicine, UNSW, Peake, Philip (deceased), Clinical School - Prince of Wales Hospital, Faculty of Medicine, UNSW.

Subjects/Keywords: Biomarkers; Acute Kidney Injury; Delayed Graft Function

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APA (6^th Edition):

Pianta, T. (2015). Biomarkers of acute kidney injury and delayed graft function. Structure, function, and the effect of treatment. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/56421 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:40689/SOURCE02?view=true

Chicago Manual of Style (16^th Edition):

Pianta, Timothy. “Biomarkers of acute kidney injury and delayed graft function. Structure, function, and the effect of treatment.” 2015. Doctoral Dissertation, University of New South Wales. Accessed April 13, 2021. http://handle.unsw.edu.au/1959.4/56421 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:40689/SOURCE02?view=true.

MLA Handbook (7^th Edition):

Pianta, Timothy. “Biomarkers of acute kidney injury and delayed graft function. Structure, function, and the effect of treatment.” 2015. Web. 13 Apr 2021.

Vancouver:

Pianta T. Biomarkers of acute kidney injury and delayed graft function. Structure, function, and the effect of treatment. [Internet] [Doctoral dissertation]. University of New South Wales; 2015. [cited 2021 Apr 13]. Available from: http://handle.unsw.edu.au/1959.4/56421 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:40689/SOURCE02?view=true.

Council of Science Editors:

Pianta T. Biomarkers of acute kidney injury and delayed graft function. Structure, function, and the effect of treatment. [Doctoral Dissertation]. University of New South Wales; 2015. Available from: http://handle.unsw.edu.au/1959.4/56421 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:40689/SOURCE02?view=true

University of New South Wales

11. Abdul Cader, Mohamed Fahim. Human nephrotoxicity assessment using novel renal biomarkers following herbicide self-poisoning in less developed countries.

Degree: Clinical School - Prince of Wales Hospital, 2015, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/54941 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:36223/SOURCE02?view=true

► Acute kidney injury (AKI) following self-poisoning with herbicides is common and an important predictor of mortality. Early diagnosis may reduce mortality if successful treatments are… (more)

▼ Acute kidney injury (AKI) following self-poisoning with herbicides is common and an important predictor of mortality. Early diagnosis may reduce mortality if successful treatments are developed. AKI is diagnosed by changes in serum creatinine (sCr), a surrogate of glomerular filtration rate (GFR). This delays diagnosis and underestimates extent of injury, so use of sCr to diagnose nephrotoxicity is suboptimal. We prospectively studied Sri Lankan subjects admitted to hospitals following deliberate drug/chemical ingestion and after snake envenomation. This thesis focuses on two herbicides, paraquat and glyphosate. Firstly, we hypothesised that the abrupt increase in sCr following paraquat poisoning was so rapid and was unlikely to be due solely to nephrotoxicity. We assessed this by comparing kinetics of sCr and serum cystatin C, and influences of non-renal factors. The increase in creatinine greatly exceeded that predicted or even possible with maximal decreases in GFR. We speculated this represents increased production of creatine and creatinine to meet energy demands following paraquat-induced oxidative stress. Creatinine was not a good marker of GFR and paraquat nephrotoxicity should be evaluated using more specific renal biomarkers.The utility of 10 structural injury biomarkers was then evaluated. Three (urinary cystatin C, NGAL and clusterin) of 10 showed a modest performance in detecting AKI. Most patients with AKI died due to multi-organ failure within 2 days and sCr predicted mortality independently of GFR. Therefore, any additional clinical utility of injury biomarkers to sCr was limited in paraquat poisoning.We assessed the influence of proteinuria on biomarker excretion. Albuminuria was associated with increased excretion of most biomarkers and biomarker cutoffs for prediction of death were higher. Diagnostic cutoffs for outcome prediction and stratification must be modified if albuminuria is due to comorbid conditions.Finally, the role of biomarkers in detecting nephrotoxicity and their added value to sCr was evaluated in 90 patients following glyphosate-surfactant herbicide (GPSH) poisoning. GPSH-induced nephrotoxicity was common but generally mild and reversible. It can be diagnosed within 8-16 hours by cytochrome C (uCytoC). The early increases in uCytoC and interleukin-18 support a primary mechanism of GPSH-induced nephrotoxicity involving mitochondrial toxicity and apoptosis and use of these biomarkers may identify mechanism-specific targets for treatments. Advisors/Committee Members: Buckley, Nicholas Allan, Clinical School - Prince of Wales Hospital, Faculty of Medicine, UNSW, Endre, Zoltan Huba, Clinical School - Prince of Wales Hospital, Faculty of Medicine, UNSW.

Subjects/Keywords: Herbicide Poisoning; Acute Kidney Injury; Biomarkers

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APA (6^th Edition):

Abdul Cader, M. F. (2015). Human nephrotoxicity assessment using novel renal biomarkers following herbicide self-poisoning in less developed countries. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/54941 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:36223/SOURCE02?view=true

Chicago Manual of Style (16^th Edition):

Abdul Cader, Mohamed Fahim. “Human nephrotoxicity assessment using novel renal biomarkers following herbicide self-poisoning in less developed countries.” 2015. Doctoral Dissertation, University of New South Wales. Accessed April 13, 2021. http://handle.unsw.edu.au/1959.4/54941 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:36223/SOURCE02?view=true.

MLA Handbook (7^th Edition):

Abdul Cader, Mohamed Fahim. “Human nephrotoxicity assessment using novel renal biomarkers following herbicide self-poisoning in less developed countries.” 2015. Web. 13 Apr 2021.

Vancouver:

Abdul Cader MF. Human nephrotoxicity assessment using novel renal biomarkers following herbicide self-poisoning in less developed countries. [Internet] [Doctoral dissertation]. University of New South Wales; 2015. [cited 2021 Apr 13]. Available from: http://handle.unsw.edu.au/1959.4/54941 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:36223/SOURCE02?view=true.

Council of Science Editors:

Abdul Cader MF. Human nephrotoxicity assessment using novel renal biomarkers following herbicide self-poisoning in less developed countries. [Doctoral Dissertation]. University of New South Wales; 2015. Available from: http://handle.unsw.edu.au/1959.4/54941 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:36223/SOURCE02?view=true

University of Cincinnati

12. Hanson, Holly R, M.D. Describing Pediatric Acute Kidney Injury in the Emergency Department.

Degree: MS, Medicine: Clinical and Translational Research, 2016, University of Cincinnati

URL: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1459528673

► Background: Acute kidney injury (AKI), caused by decreased renal perfusion or a direct kidney insult, results in increased morbidity and mortality independent of underlying disease… (more)

▼ Background: Acute kidney injury (AKI), caused by decreased renal perfusion or a direct kidney insult, results in increased morbidity and mortality independent of underlying disease pathology in children. Early recognition, particularly in the Emergency Department (ED), is paramount to mitigate further injury induced by nephrotoxic treatments. Diagnosis of AKI by current definition utilizing changes in serum creatinine (SCr) is challenging in the pediatric setting and can lead to delayed recognition. No studies have defined the scope of this problem from the pediatric ED.Objectives: To (1) define those children who develop AKI within 48 hours of admission from the ED and (2) ascertain patient-related factors identifiable in the ED that is associated with AKI. Study Design: This is a retrospective, observational study of children birth to 19 years of age who were admitted to a pediatric hospital from the ED between 01/2010 and 12/2013 and had a SCr drawn within the first 48 hours. Exclusion criteria included being anephric, a history of chronic kidney disease stage IV or V, or a recent admission/surgery within 72 hours of presentation. AKI was defined as a serum creatinine = 1.5 times baseline or, where baseline not present it was imputed using an estimated creatinine clearance of 120 ml/min/1.73 m2. Demographics, medical history, laboratory values, medications, procedures, and disposition were extracted. Frequencies were used to characterize the population. Differences between groups were determined by t-tests or chi-square analysis. A list of patient-related factors associated with AKI in the ED was formulated a priori based on current literature and included demographics, past medical history, past surgical history, ED procedures, ED medications, and disposition. Bivariable and multivariable logistic regression was performed to determine factors associated with development of AKI. Results: The study cohort comprised 13,827 subjects, of which 1,436 (10.4%) had AKI (34.8% were SCr = 2.0 times above baseline) and 1083 (75%) were identifiable in the ED. Of those kids with AKI, 2.7% required dialysis, 0.6% required intubation in the ED, 0.4% had inotropy started in the ED, 17.2% required central venous access, and 2.0% died during the hospital admission (all significantly more than children without AKI). Nearly 20% with AKI received a nephrotoxic medication in the ED. All factors identified a priori were entered into the bivariable model, had a p < 0.25, and then were added to the multivariable model. Young age, history of AKI, history of solid organ transplant, receiving intravenous fluids in the ED, central venous access in the ED, and admission to the intensive care unit (ICU) were all factors independently associated with AKI.Conclusions: One child per day, admitted at a large tertiary hospital, had AKI while in the ED. 25% were not identifiable by current methods. Young age, history of solid organ transplant and AKI, need for central venous access, intravenous fluid in the ED and ICU admission are all independently… Advisors/Committee Members: Haynes, Erin Nicole (Committee Chair).

Subjects/Keywords: Surgery; Pediatrics; Acute Kidney Injury; Emergency Department

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APA (6^th Edition):

Hanson, Holly R, M. D. (2016). Describing Pediatric Acute Kidney Injury in the Emergency Department. (Masters Thesis). University of Cincinnati. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=ucin1459528673

Chicago Manual of Style (16^th Edition):

Hanson, Holly R, M D. “Describing Pediatric Acute Kidney Injury in the Emergency Department.” 2016. Masters Thesis, University of Cincinnati. Accessed April 13, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1459528673.

MLA Handbook (7^th Edition):

Hanson, Holly R, M D. “Describing Pediatric Acute Kidney Injury in the Emergency Department.” 2016. Web. 13 Apr 2021.

Vancouver:

Hanson, Holly R MD. Describing Pediatric Acute Kidney Injury in the Emergency Department. [Internet] [Masters thesis]. University of Cincinnati; 2016. [cited 2021 Apr 13]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1459528673.

Council of Science Editors:

Hanson, Holly R MD. Describing Pediatric Acute Kidney Injury in the Emergency Department. [Masters Thesis]. University of Cincinnati; 2016. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1459528673

13. Marcus Felipe Bezerra da Costa. Estudo do efeito nefroprotetor do extrato alcoÃlico de prÃpolis vermelha em um modelo de lesÃo renal aguda por isquemia/reperfusÃo em ratos.

Degree: 2013, Universidade Federal do CearÃ; Programa de PÃs-GraduaÃÃo em Farmacologia; UFC; BR

URL: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=11385

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Kidney disease remains a public health problem worldwide, where there is an increase in the number of incidence of Acute Kidney Injury (AKI) in hospitalized… (more)

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Kidney disease remains a public health problem worldwide, where there is an increase in the number of incidence of Acute Kidney Injury (AKI) in hospitalized patients. The AKI is characterized by an abrupt decrease in renal function, resulting in the inability of the kidneys to perform itÂs basics functions. The Ischemia/Reperfusion (I/R) injury can be defined as all changes resulting from the deprivation and the re-establishment of the oxygen supply to tissues and organs. It is a complex process that results in the production of reactive oxygen species (ROS) and oxidative stress damage. The Brazilian Red Propolis is a complex mixture collected and produced by Apis mellifera bees, and seems to be promising in this context, attenuating the oxidative and nephrotoxic effect in the kidney. This experimental study aims to replicate and standardize a framework of AKI by Ischemia/reperfusion (I/R) in rats, and analyze the possible protective renal effects of Red Propolis Alcohol Extract (RPAE) at a dose of 150mg/kg on markers and pathological variables. Wistar rats, adult males, were divided into 4 groups, using an induction and treatment regimen. We evaluated biochemical parameters indicative of renal function (creatinine, urea, creatinine clearance) tubular function (FENa+ and FEK+), oxidative profile through MDA (malondialdehyde) and activity of antioxidant enzyme GSH, in addition to histological analysis and immunohistochemistry. The RPAE significantly altered almost all parameters investigated. The results demonstrated the protective effect of the extract in the dose used against the nephrotoxicity: decreased serum levels of creatinine (1.8 Â 0.5 vs 2,7Â0,9) and urea (181.1 Â 65.6 vs 274,3Â91,81), reversed the increase in FENa+ (0,58Â0,30 vs 1,03Â0,39) and FEK+ (64,74Â52,44 vs 134,4Â54,94), reversed the decrease of creatinine clearance (0,41Â0,14 vs 0,073Â0,048), decreased MDA levels (90,22Â20,82 vs 133,9Â23,36) and increased GSH (1784Â297,4 vs 1267Â229,5), decreased the rate of acute tubular necrosis (2,0Â0,7 vs 3,6Â0,5), increased the expression of eNOS (2,20,4 vs 0,60,5) and Heme-oxygenase (2,60,5 vs 1,40,5). Therefore, occurred protection of renal function, protection of the tubular damage and oxidative stress. These results describe for the first time the effect of Red Propolis on a model of AKI induced by I/R, suggesting the protective effect of the extract against this type of injury.

As doenÃas renais apresentam um problema de saÃde pÃblica mundial, aonde hÃ um aumento nos nÃmeros de incidÃncia de LesÃo Renal Aguda (LRA) em pacientes hospitalizados. A LRA caracteriza-se por uma reduÃÃo abrupta da funÃÃo renal, resultando na incapacidade dos rins em exercer suas funÃÃes bÃsicas. A lesÃo por isquemia/reperfusÃo (I/R) pode ser definida como as alteraÃÃes resultantes da privaÃÃo seguida do re-estabelecimento do fornecimento de oxigÃnio para tecidos e ÃrgÃos. Ã um processo complexo, que resulta na produÃÃo espÃcies reativas de oxigÃnio (EROs) e dano por estresse oxidativo. A…

Advisors/Committee Members: Alice Maria Costa Martins, Elizabeth de Francesco Daher, LucÃlia Maria Abreu Lessa.

Subjects/Keywords: Propolis; Acute Kidney Injury; Ischemia; FARMACOLOGIA

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APA (6^th Edition):

Costa, M. F. B. d. (2013). Estudo do efeito nefroprotetor do extrato alcoÃlico de prÃpolis vermelha em um modelo de lesÃo renal aguda por isquemia/reperfusÃo em ratos. (Masters Thesis). Universidade Federal do CearÃ; Programa de PÃs-GraduaÃÃo em Farmacologia; UFC; BR. Retrieved from http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=11385

Chicago Manual of Style (16^th Edition):

Costa, Marcus Felipe Bezerra da. “Estudo do efeito nefroprotetor do extrato alcoÃlico de prÃpolis vermelha em um modelo de lesÃo renal aguda por isquemia/reperfusÃo em ratos.” 2013. Masters Thesis, Universidade Federal do CearÃ; Programa de PÃs-GraduaÃÃo em Farmacologia; UFC; BR. Accessed April 13, 2021. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=11385.

MLA Handbook (7^th Edition):

Costa, Marcus Felipe Bezerra da. “Estudo do efeito nefroprotetor do extrato alcoÃlico de prÃpolis vermelha em um modelo de lesÃo renal aguda por isquemia/reperfusÃo em ratos.” 2013. Web. 13 Apr 2021.

Vancouver:

Costa MFBd. Estudo do efeito nefroprotetor do extrato alcoÃlico de prÃpolis vermelha em um modelo de lesÃo renal aguda por isquemia/reperfusÃo em ratos. [Internet] [Masters thesis]. Universidade Federal do CearÃ; Programa de PÃs-GraduaÃÃo em Farmacologia; UFC; BR; 2013. [cited 2021 Apr 13]. Available from: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=11385.

Council of Science Editors:

Costa MFBd. Estudo do efeito nefroprotetor do extrato alcoÃlico de prÃpolis vermelha em um modelo de lesÃo renal aguda por isquemia/reperfusÃo em ratos. [Masters Thesis]. Universidade Federal do CearÃ; Programa de PÃs-GraduaÃÃo em Farmacologia; UFC; BR; 2013. Available from: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=11385

14. Sato, Ko. Nephrotoxicity of cisplatin combination chemotherapy in thoracic malignancy patients with CKD risk factors. : 合併症を有する胸部悪性腫瘍患者に対するシスプラチン併用化学療法の腎障害のリスク解析.

Degree: 博士（医学）, 2017, Niigata University / 新潟大学

URL: http://hdl.handle.net/10191/47613

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学位の種類: 博士（医学）. 報告番号: 甲第4268号. 学位記番号: 新大院博（医）甲第746号. 学位授与年月日: 平成29年3月23日

BMC Cancer. 2016; 16: 222

Background : Nephrotoxicity is the major side effect that limits the dose… (more)

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学位の種類: 博士（医学）. 報告番号: 甲第4268号. 学位記番号: 新大院博（医）甲第746号. 学位授与年月日: 平成29年3月23日

BMC Cancer. 2016; 16: 222

Background : Nephrotoxicity is the major side effect that limits the dose of cisplatin that can be safely administered, and it is a clinical problem in cancer patients who received cisplatin combination chemotherapy. Recent evidence has demonstrated that patients with chronic kidney disease (CKD) have an increased risk of developing acute kidney injury (AKI). The present study was conducted to evaluate the prevalence of CKD risk factors in patients who received cisplatin and to assess the correlation between CKD risk factors and cisplatin-induced AKI.Methods : We retrospectively analyzed 84 patients treated with cisplatin combination chemotherapy for thoracic malignancies. AKI was defined as a decrease in the estimated glomerular filtration rate (eGFR) > 25 % from base line, an increase in the serum creatinine (sCre) level of > 0.3 mg/dl or ≥ 1.5 times the baseline level.Results : Eighty of the 84 patients (95.2 %) had at least one risk factor for CKD. All enrolled patients received cisplatin with hydration, magnesium supplementation and mannitol. Cisplatin-induced AKI was observed in 18 patients (21.4 %). Univariate analysis revealed that cardiac disease and use of non-steroidal anti-inflammatory drugs (NSAIDs) were associated with cisplatin-induced nephrotoxicity (odds ratios [OR] 6 and 3.56, 95 % confidence intervals [CI] 1.21–29.87 and 1.11–11.39, p = 0.04 and p = 0.04, respectively). Multivariate analysis revealed that cisplatin nephrotoxicity occurred significantly more often in patients with both risk factors (OR 13.64, 95 % CI 1.11–326.83, p = 0.04). Patients with more risk factors for CKD tended to have a greater risk of developing cisplatin-induced AKI.Conclusions : We should consider avoiding administration of cisplatin to patients with CKD risk factors, particularly cardiac disease and NSAID use.

Subjects/Keywords: Cisplatin; Nephrotoxicity; Chronic kidney disease; Acute kidney injury

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APA (6^th Edition):

Sato, K. (2017). Nephrotoxicity of cisplatin combination chemotherapy in thoracic malignancy patients with CKD risk factors. : 合併症を有する胸部悪性腫瘍患者に対するシスプラチン併用化学療法の腎障害のリスク解析. (Thesis). Niigata University / 新潟大学. Retrieved from http://hdl.handle.net/10191/47613

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sato, Ko. “Nephrotoxicity of cisplatin combination chemotherapy in thoracic malignancy patients with CKD risk factors. : 合併症を有する胸部悪性腫瘍患者に対するシスプラチン併用化学療法の腎障害のリスク解析.” 2017. Thesis, Niigata University / 新潟大学. Accessed April 13, 2021. http://hdl.handle.net/10191/47613.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sato, Ko. “Nephrotoxicity of cisplatin combination chemotherapy in thoracic malignancy patients with CKD risk factors. : 合併症を有する胸部悪性腫瘍患者に対するシスプラチン併用化学療法の腎障害のリスク解析.” 2017. Web. 13 Apr 2021.

Vancouver:

Sato K. Nephrotoxicity of cisplatin combination chemotherapy in thoracic malignancy patients with CKD risk factors. : 合併症を有する胸部悪性腫瘍患者に対するシスプラチン併用化学療法の腎障害のリスク解析. [Internet] [Thesis]. Niigata University / 新潟大学; 2017. [cited 2021 Apr 13]. Available from: http://hdl.handle.net/10191/47613.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sato K. Nephrotoxicity of cisplatin combination chemotherapy in thoracic malignancy patients with CKD risk factors. : 合併症を有する胸部悪性腫瘍患者に対するシスプラチン併用化学療法の腎障害のリスク解析. [Thesis]. Niigata University / 新潟大学; 2017. Available from: http://hdl.handle.net/10191/47613

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

15. Nakada, Yasuki; Kawakami, Rika; Matsui, Masaru; Ueda, Tomoya; Nakano, Tomoya; Takitsume, Akihiro; Nakagawa, Hitoshi; Nishida, Taku; Onoue, Kenji; Soeda, Tsunenari; Okayama, Satoshi; Watanabe, Makoto; Kawata, Hiroyuki; Okura, Hiroyuki. Prognostic Value of Urinary Neutrophil Gelatinase-Associated Lipocalin on the First Day of Admission for Adverse Events in Patients With Acute Decompensated Heart Failure. : 入院初日の尿中好中球ゼラチナーゼ結合性リポカリンは急性心不全患者の重要な予後予測因子である.

Degree: 博士（医学）, 2017, Nara Medical University / 奈良県立医科大学

URL: http://hdl.handle.net/10564/3386

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Background Urinary neutrophil gelatinase‐associated lipocalin (U‐NGAL) is an early predictor of acute kidney injury and adverse events in various diseases; however, in acute decompensated heart… (more)

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Background Urinary neutrophil gelatinase‐associated lipocalin (U‐NGAL) is an early predictor of acute kidney injury and adverse events in various diseases; however, in acute decompensated heart failure patients, its significance remains poorly understood. This study aimed to investigate the prognostic value of U‐NGAL on the first day of admission for the occurrence of acute kidney injury and long‐term outcomes in acute decompensated heart failure patients. Methods and Results We studied 260 acute decompensated heart failure patients admitted to our department between 2011 and 2014 by measuring U‐NGAL in 24‐hour urine samples collected on the first day of admission. Primary end points were all‐cause eath, cardiovascular death, and heart failure admission. Patients were divided into 2 groups according to their median U‐NGAL levels (32.5 μg/gCr). The high‐U‐NGAL group had a significantly higher occurrence of acute kidney injury during hospitalization than the low‐U‐NGAL group (P=0.0012). Kaplan‐Meier analysis revealed that the high‐U‐NGAL group exhibited a worse prognosis than the low‐U‐NGAL group in all‐cause death (hazard ratio 2.07; 95%CI 1.38‐3.12, P=0.0004), cardiovascular death (hazard ratio 2.29; 95%CI 1.28‐4.24, P=0.0052), and heart failure admission (hazard ratio 1.77; 95%CI 1.13‐2.77, P=0.0119). The addition of U‐NGAL to the estimated glomerular filtration rate significantly improved the predictive accuracy of all‐cause mortality (P=0.0083). Conclusions In acute decompensated heart failure patients, an elevated U‐NGAL level on the first day of admission was related to the development of clinical acute kidney injury and independently associated with poor prognosis.

博士（医学）・甲第675号・平成29年11月24日

Copyright & Usage: © 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License(http://creativecommons.org/licenses/by-nc/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Subjects/Keywords: acute heart failure; acute kidney injury; neutrophil gelatinase‐associated lipocalin; outcomes

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APA (6^th Edition):

Nakada, Yasuki; Kawakami, Rika; Matsui, Masaru; Ueda, Tomoya; Nakano, Tomoya; Takitsume, Akihiro; Nakagawa, Hitoshi; Nishida, Taku; Onoue, Kenji; Soeda, Tsunenari; Okayama, Satoshi; Watanabe, Makoto; Kawata, Hiroyuki; Okura, H. (2017). Prognostic Value of Urinary Neutrophil Gelatinase-Associated Lipocalin on the First Day of Admission for Adverse Events in Patients With Acute Decompensated Heart Failure. : 入院初日の尿中好中球ゼラチナーゼ結合性リポカリンは急性心不全患者の重要な予後予測因子である. (Thesis). Nara Medical University / 奈良県立医科大学. Retrieved from http://hdl.handle.net/10564/3386

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Nakada, Yasuki; Kawakami, Rika; Matsui, Masaru; Ueda, Tomoya; Nakano, Tomoya; Takitsume, Akihiro; Nakagawa, Hitoshi; Nishida, Taku; Onoue, Kenji; Soeda, Tsunenari; Okayama, Satoshi; Watanabe, Makoto; Kawata, Hiroyuki; Okura, Hiroyuki. “Prognostic Value of Urinary Neutrophil Gelatinase-Associated Lipocalin on the First Day of Admission for Adverse Events in Patients With Acute Decompensated Heart Failure. : 入院初日の尿中好中球ゼラチナーゼ結合性リポカリンは急性心不全患者の重要な予後予測因子である.” 2017. Thesis, Nara Medical University / 奈良県立医科大学. Accessed April 13, 2021. http://hdl.handle.net/10564/3386.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Nakada, Yasuki; Kawakami, Rika; Matsui, Masaru; Ueda, Tomoya; Nakano, Tomoya; Takitsume, Akihiro; Nakagawa, Hitoshi; Nishida, Taku; Onoue, Kenji; Soeda, Tsunenari; Okayama, Satoshi; Watanabe, Makoto; Kawata, Hiroyuki; Okura, Hiroyuki. “Prognostic Value of Urinary Neutrophil Gelatinase-Associated Lipocalin on the First Day of Admission for Adverse Events in Patients With Acute Decompensated Heart Failure. : 入院初日の尿中好中球ゼラチナーゼ結合性リポカリンは急性心不全患者の重要な予後予測因子である.” 2017. Web. 13 Apr 2021.

Vancouver:

Nakada, Yasuki; Kawakami, Rika; Matsui, Masaru; Ueda, Tomoya; Nakano, Tomoya; Takitsume, Akihiro; Nakagawa, Hitoshi; Nishida, Taku; Onoue, Kenji; Soeda, Tsunenari; Okayama, Satoshi; Watanabe, Makoto; Kawata, Hiroyuki; Okura H. Prognostic Value of Urinary Neutrophil Gelatinase-Associated Lipocalin on the First Day of Admission for Adverse Events in Patients With Acute Decompensated Heart Failure. : 入院初日の尿中好中球ゼラチナーゼ結合性リポカリンは急性心不全患者の重要な予後予測因子である. [Internet] [Thesis]. Nara Medical University / 奈良県立医科大学; 2017. [cited 2021 Apr 13]. Available from: http://hdl.handle.net/10564/3386.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Nakada, Yasuki; Kawakami, Rika; Matsui, Masaru; Ueda, Tomoya; Nakano, Tomoya; Takitsume, Akihiro; Nakagawa, Hitoshi; Nishida, Taku; Onoue, Kenji; Soeda, Tsunenari; Okayama, Satoshi; Watanabe, Makoto; Kawata, Hiroyuki; Okura H. Prognostic Value of Urinary Neutrophil Gelatinase-Associated Lipocalin on the First Day of Admission for Adverse Events in Patients With Acute Decompensated Heart Failure. : 入院初日の尿中好中球ゼラチナーゼ結合性リポカリンは急性心不全患者の重要な予後予測因子である. [Thesis]. Nara Medical University / 奈良県立医科大学; 2017. Available from: http://hdl.handle.net/10564/3386

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Manchester

16. Sykes, Lynne Frances. Assessing the impact of acute kidney injury in secondary care and developing strategies to improve outcomes.

Degree: 2020, University of Manchester

URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:323391

► Assessing the impact of acute kidney injury in secondary care and developing strategies to improve outcomes (Dr Lynne Sykes) Introduction: Acute kidney injury (AKI) is… (more)

▼ Assessing the impact of acute kidney injury in secondary care and developing strategies to improve outcomes (Dr Lynne Sykes) Introduction: Acute kidney injury (AKI) is associated with up to one in five emergency admissions to hospital and over 300,000 deaths per year in the UK. This thesis, presented in the alternative format, examines work undertaken to better describe the etiology of AKI in secondary care and then strategies to reduce AKI incidence, progression and complications. Methods: Selected anonymised data from the hospitalâ€™s â€˜data warehouseâ€™ was analysed using SPSS to calculate risk for mortality and critical care admission, analyse background user data, or calculate precision and bias of different point of care tests. The International Health Instituteâ€™s Breakthrough Series Model was used for our quality improvement methodology. Results: The literature review suggested education, an e-alert to trigger an AKI bundle and an in-built redundancy in the system were key to reducing mortality and critical care admission. The literature also demonstrates a high event rate of AKI and significant heterogeneity in cause and patient phenotype. The first three results chapters describe the epidemiology of our cohort of secondary care AKI patients in more detail. Chapters 3 and 4 examine the risks of different stages of AKI and the impacts they have on mortality, depending on admission diagnosis. Chapter 3 shows stark differences between patient mortality in those admitted with acute coronary syndrome and AKI 3 compared to those without AKI (OR 12.8 [4.8-33.8] p<0.001) and those admitted with fractured neck of femur and AKI 3 compared to those without (OR 24.6 [8.9-67.9]). In Chapter 4, the percentage of patients admitted with heart failure dying is similar in AKI 2 and AKI 3 (50% versus 47% respectively), demonstrating that escalating AKI stage does not always equate to escalating risk of mortality. Chapter 5 shows a specific â€˜at-riskâ€™ AKI population: patients with existing chronic kidney disease. Here, after a first AKI, subsequent episodes of AKI are more likely to be severe. Also, the risk for needing renal replacement therapy increases fourteenfold if a second AKI is stage 2 or 3, or twenty-eightfold if there are three or more episodes of AKI. The second three results chapters, Chapters 6, 7 and 8, describe the quality improvement work undertaken to reduce the incidence and progression of AKI, and also its complications. The large quality improvement programme is described in Chapter 6: it reduced hospital-acquired AKI by 22% and AKI progression by 48% on participating wards. The AKI collaborative group developed an AKI app to support education and signpost to references. Its use is detailed in Chapter 7. We compared results from point of care (POC) analysers with laboratory values in Chapter 8 and found that performance in the normal range showed excellent precision, and that in several scenarios POC tests could be used (with clinical judgment) to alter management. Conclusion: This thesis uses big data… Advisors/Committee Members: KALRA, PHILIP P, RITCHIE, JAMES J, NIPAH, ROBERT RG, Green, Darren, Kalra, Philip, Ritchie, James, Nipah, Robert.

Subjects/Keywords: AKI; acute kidney injury; quality improvement; acute renal failure

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sykes, L. F. (2020). Assessing the impact of acute kidney injury in secondary care and developing strategies to improve outcomes. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:323391

Chicago Manual of Style (16^th Edition):

Sykes, Lynne Frances. “Assessing the impact of acute kidney injury in secondary care and developing strategies to improve outcomes.” 2020. Doctoral Dissertation, University of Manchester. Accessed April 13, 2021. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:323391.

MLA Handbook (7^th Edition):

Sykes, Lynne Frances. “Assessing the impact of acute kidney injury in secondary care and developing strategies to improve outcomes.” 2020. Web. 13 Apr 2021.

Vancouver:

Sykes LF. Assessing the impact of acute kidney injury in secondary care and developing strategies to improve outcomes. [Internet] [Doctoral dissertation]. University of Manchester; 2020. [cited 2021 Apr 13]. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:323391.

Council of Science Editors:

Sykes LF. Assessing the impact of acute kidney injury in secondary care and developing strategies to improve outcomes. [Doctoral Dissertation]. University of Manchester; 2020. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:323391

Queen Mary, University of London

17. Memon, Shoab Ahmed. Novel therapies in acute kidney injury.

Degree: PhD, 2015, Queen Mary, University of London

URL: http://qmro.qmul.ac.uk/xmlui/handle/123456789/8762 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667397

► Renal ischaemia-reperfusion injury (IRI) is a major cause of acute kidney injury (AKI) which is in turn the leading cause of morbidity and mortality in… (more)

▼ Renal ischaemia-reperfusion injury (IRI) is a major cause of acute kidney injury (AKI) which is in turn the leading cause of morbidity and mortality in hospitalized patients. The principle aim of this thesis was to evaluate potential new therapies that might afford protection against IRI in both in vitro and in vivo settings. Recent evidence suggests that nitrite (NO2-) may play an important role in protecting the myocardium from IRI. Our initial work into the role of NO2- in an in vitro model of renal IRI in proximal tubular epithelial cells provided evidence that NO2- can prevent apoptosis and preserve cell viability. This lead to an in vivo study where high NO2- concentrations (50 mg/L) were given orally to rats for 7 days prior to inducing renal IRI but no beneficial effects of this treatment were observed. Another potential treatment identified was thiamine (vitamin B1) and this, like NO2-was investigated to see if it had the potential to protect rats from AKI injury. It has been previously recognized that in renal IRI the high energy phosphate ATP is found to be severely depleted whilst is is known that thiamine can play a pivotal role in generating ATP. Furthermore, thiamine has previously been demonstrated to protect against myocardial ischaemic injury and has the ability to reduce myocardial infarct size. In vitro, thiamine was found to reduce the degree of apoptosis in cultured HK-2 cells caused by ischaemia whilst in vivo it afforded protection against AKI caused by renal IRI by anti-apoptotic, anti-inflammatory and anti-oxidant mechanisms. Finally, a study into the possible therapeutic role of gene therapy with bone morphogenic protein 7 (BMP-7) in renal IRI was undertaken. Previous work has established that i.v. BMP-7 is able to protect against renal IRI but it has also been associated with ectopic bone formation at the site of injection. Therefore another method to increase circulating BMP-7 was sought. We initially found that BMP-7 gene therapy could attenuate apoptosis and preserves cell viability in an in vitro model of renal IRI. However, whilst in vivo gene therapy with electroporation of BMP-7 plasmid DNA increased BMP-7 expression in mice serum 2 days post electroporation, it was unable to protect the animals against IRI induced AKI. In rats the direct injection of naked DNA BMP-7 plasmid systematic 2 days prior to renal IRI was able to upregulate BMP-7 expression 4 days later in kidney tissue. Despite this it was unable to afford protection against renal IRI. Apoptosis and necrosis play a crucial role in the pathogenesis of renal IRI induced AKI. In this thesis we investigated the role of three putative therapeutic agents and their role in apoptosis and necrosis in vitro in PTECs and in vivo against renal IRI induced AKI. All three therapeutic drugs were able to attenuate apoptosis in PTECs but were unable to protect against necrosis, whilst against renal IRI induced AKI only thiamine was found to be protective. Thiamine appears to hold the most promise and more work needs to be undertaken so…

Subjects/Keywords: 616.6; Translational Medicine & Therapeutics; Acute Kidney Injury; ischaemia-reperfusion injury

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Memon, S. A. (2015). Novel therapies in acute kidney injury. (Doctoral Dissertation). Queen Mary, University of London. Retrieved from http://qmro.qmul.ac.uk/xmlui/handle/123456789/8762 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667397

Chicago Manual of Style (16^th Edition):

Memon, Shoab Ahmed. “Novel therapies in acute kidney injury.” 2015. Doctoral Dissertation, Queen Mary, University of London. Accessed April 13, 2021. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8762 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667397.

MLA Handbook (7^th Edition):

Memon, Shoab Ahmed. “Novel therapies in acute kidney injury.” 2015. Web. 13 Apr 2021.

Vancouver:

Memon SA. Novel therapies in acute kidney injury. [Internet] [Doctoral dissertation]. Queen Mary, University of London; 2015. [cited 2021 Apr 13]. Available from: http://qmro.qmul.ac.uk/xmlui/handle/123456789/8762 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667397.

Council of Science Editors:

Memon SA. Novel therapies in acute kidney injury. [Doctoral Dissertation]. Queen Mary, University of London; 2015. Available from: http://qmro.qmul.ac.uk/xmlui/handle/123456789/8762 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667397

University of Melbourne

18. O'Kane, Dermot Bernard. Protection of the kidney against Ischaemia-Reperfusion injury using zinc.

Degree: 2019, University of Melbourne

URL: http://hdl.handle.net/11343/235624

► Acute kidney injury (AKI) continues to be a major cause of morbidity and mortality worldwide. Septic shock, hypovolaemia, and renal ischaemia related to major surgeries… (more)

▼ Acute kidney injury (AKI) continues to be a major cause of morbidity and mortality worldwide. Septic shock, hypovolaemia, and renal ischaemia related to major surgeries are the primary contributors to AKI in hospitalised patients. AKI is associated with a four-fold increase in mortality in hospitalised patients, and a two-fold increase in the likelihood of discharge to a short- or long-term care facility. As a result, the estimated healthcare costs associated with AKI in hospitalised patients in the US alone exceeds US$10billion per year. Studies have also demonstrated that AKI resulting from ischaemia-reperfusion (IR) is a causative determinant in the development, and progression, of chronic kidney disease (CKD). Despite major medical advances to the current day, short of supportive measures there is still no definitive therapeutic option available to prevent AKI in these settings. Preconditioning (PC) against renal IR injury has been heralded as a promising solution to abrogate this major healthcare problem, and an extensive volume of research has amassed in this area. Preconditioning is a phenomenon whereby an innate tissue adaptation occurs in response to a sublethal stimulus, which leads to protection of an organ or tissue against a subsequent insult. PC was first discovered in the context of ischaemic PC (IPC), where brief sublethal periods of ischaemia led to protection against a subsequent more sustained period of ischaemia in the canine heart. Since the discovery of the IPC phenomenon in 1986, tissue protection against ischaemia by means of IPC has been demonstrated by a number of methods in a variety of tissues, including the heart, brain, liver, kidney, and striated smooth muscle. The promise of these findings has also prompted research into the use of alternative methods of tissue PC, and studies have since investigated the use of pharmaceutical agents to promote these tissue adaptations by pharmacological preconditioning (PPC). The race for a pharmaceutical agent capable of eliciting protective adaptations against tissue ischaemia has involved many classes of pharmaceutical compounds, endogenous proteins, and trace elements. Zinc (Zn) is a metal that is essential to many biological functions, including cell growth and survival. The omnipresence of Zn in cellular interactions, and its importance in so many biological processes has led to the investigation of augmenting Zn homeostasis as a means of protection against tissue ischaemia. This is the primary topic of this thesis. The promise of enabling organ protection against IR injury has major clinical implications, spanning many areas of medicine. However, despite the extensive volume of clinical and basic science research in this area, there is still currently no effective method of PC that will protect the human kidney against IR injury. The aims of this thesis are to investigate if parenteral Zn can be used as a therapeutic strategy to protect the kidney against IR injury. The body of research on the topic of tissue PC has highlighted some…

Subjects/Keywords: Preconditioning; Ischaemia-reperfusion injury; Acute kidney injury; Zinc; Succinate

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

O'Kane, D. B. (2019). Protection of the kidney against Ischaemia-Reperfusion injury using zinc. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/235624

Chicago Manual of Style (16^th Edition):

O'Kane, Dermot Bernard. “Protection of the kidney against Ischaemia-Reperfusion injury using zinc.” 2019. Doctoral Dissertation, University of Melbourne. Accessed April 13, 2021. http://hdl.handle.net/11343/235624.

MLA Handbook (7^th Edition):

O'Kane, Dermot Bernard. “Protection of the kidney against Ischaemia-Reperfusion injury using zinc.” 2019. Web. 13 Apr 2021.

Vancouver:

O'Kane DB. Protection of the kidney against Ischaemia-Reperfusion injury using zinc. [Internet] [Doctoral dissertation]. University of Melbourne; 2019. [cited 2021 Apr 13]. Available from: http://hdl.handle.net/11343/235624.

Council of Science Editors:

O'Kane DB. Protection of the kidney against Ischaemia-Reperfusion injury using zinc. [Doctoral Dissertation]. University of Melbourne; 2019. Available from: http://hdl.handle.net/11343/235624

University of Minnesota

19. Gisewhite, Sarah. Assessment Of Urinary Metabolites In Risk Prediction Of Acute Kidney Injury.

Degree: MS, Integrated Biosciences, 2020, University of Minnesota

URL: http://hdl.handle.net/11299/214994

► Acute kidney injury (AKI) is the sudden decrease or loss of kidney function caused by direct kidney injury or functional impairment. Many patients do not… (more)

Subjects/Keywords: acute kidney injury; biomarkers; combat injury; metabolites; NMR; risk prediction

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gisewhite, S. (2020). Assessment Of Urinary Metabolites In Risk Prediction Of Acute Kidney Injury. (Masters Thesis). University of Minnesota. Retrieved from http://hdl.handle.net/11299/214994

Chicago Manual of Style (16^th Edition):

Gisewhite, Sarah. “Assessment Of Urinary Metabolites In Risk Prediction Of Acute Kidney Injury.” 2020. Masters Thesis, University of Minnesota. Accessed April 13, 2021. http://hdl.handle.net/11299/214994.

MLA Handbook (7^th Edition):

Gisewhite, Sarah. “Assessment Of Urinary Metabolites In Risk Prediction Of Acute Kidney Injury.” 2020. Web. 13 Apr 2021.

Vancouver:

Gisewhite S. Assessment Of Urinary Metabolites In Risk Prediction Of Acute Kidney Injury. [Internet] [Masters thesis]. University of Minnesota; 2020. [cited 2021 Apr 13]. Available from: http://hdl.handle.net/11299/214994.

Council of Science Editors:

Gisewhite S. Assessment Of Urinary Metabolites In Risk Prediction Of Acute Kidney Injury. [Masters Thesis]. University of Minnesota; 2020. Available from: http://hdl.handle.net/11299/214994

20. Wei, Jin. Acute Kidney Injury and Chronic Kidney Disease.

Degree: 2017, University of South Florida

URL: https://scholarcommons.usf.edu/etd/6780

► Ischemia and reperfusion are natural steps during kidney transplantation, and IRI is considered one of the most important nonspecific factors affecting allograft dysfunction. Transplanted organs… (more)

Subjects/Keywords: Acute Kidney Injury; Ischemia Reperfusion Injury; Chronic Kidney Disease; Renal Hemodynamic; Physiology

11 more images…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wei, J. (2017). Acute Kidney Injury and Chronic Kidney Disease. (Thesis). University of South Florida. Retrieved from https://scholarcommons.usf.edu/etd/6780

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wei, Jin. “Acute Kidney Injury and Chronic Kidney Disease.” 2017. Thesis, University of South Florida. Accessed April 13, 2021. https://scholarcommons.usf.edu/etd/6780.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wei, Jin. “Acute Kidney Injury and Chronic Kidney Disease.” 2017. Web. 13 Apr 2021.

Vancouver:

Wei J. Acute Kidney Injury and Chronic Kidney Disease. [Internet] [Thesis]. University of South Florida; 2017. [cited 2021 Apr 13]. Available from: https://scholarcommons.usf.edu/etd/6780.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wei J. Acute Kidney Injury and Chronic Kidney Disease. [Thesis]. University of South Florida; 2017. Available from: https://scholarcommons.usf.edu/etd/6780

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Penn State University

21. Wang, Luojun. The Joint Modeling of Recurrent Events and Other Failure Time Events.

Degree: 2016, Penn State University

URL: https://submit-etda.libraries.psu.edu/catalog/xd07gs69t

► Recurrent events are commonly encountered in biomedical research studies and clinical trials. Many previous studies are done to investigate recurrent event analysis. As introduced in… (more)

▼ Recurrent events are commonly encountered in biomedical research studies and clinical trials. Many previous studies are done to investigate recurrent event analysis. As introduced in Chapter 1, some of the early work on recurrent event focuses on survival outcomes and others on longitudinal outcomes. If recurrent events are correlated with a failure event, such as death, we no longer should assume independent censoring. Many reports in the literature incorporate a latent variable model to account for the correlation between the time to event T and the number of recurrent events N(t). We fi�rst jointly model the time to primary outcome and the number of recurrent events with the frailty model, using a Zero-inflated-Poisson-Weibull distribution. We develop the analytical forms and details in the full parametric setting; however, such a model may be over-parameterized and di�cult to apply, which limits us from applying full likelihood-based analyses. Because of the limitation of the frailty model, we propose a joint distribution for (T;N) based on conditional distributions. We illustrate the use of this joint distribution to model the recurrent events of acute kidney injury (AKI) and time to primary outcome (death) in patients with and without chronic kidney disease (CKD) and AKI. In this fully parametric model, we develop the intensity ratio for the recurrent events and the hazard ratios for the failure event among different groups of patients with or without an AKI event at the index hospitalization and with or without CKD at the index hospitalization. Based on our model, we then investigate if recurrent AKI is predictive of death. Further, we are interested in a non-terminal event, such as End Stage Renal Disease (ESRD), which may be censored by a terminal event (Death), but not vice versa. The previous methods, such as a cause-speci�c hazards model and a subdistribution hazards model are based on the independence assumption, which is not appropriate in such case. Therefore, we introduce and develop a semi competing risk approach with a Gaussian copula, using the tri-variate Weibull distribution. Then we illustrate the results from di�fferent approaches with a simulated data example. Finally, we compare di�fferent tri-variate Weibull distributions with Gaussian copula, Clayton copula or under independence, via a series of simulation studies. Two sets of data are generated by tri-variate Weibull distributions with either Gaussian or Clayton copula, to test the bias of performances with each method. Advisors/Committee Members: Vernon Michael Chinchilli, Dissertation Advisor/Co-Advisor, Vernon Michael Chinchilli, Committee Chair/Co-Chair, David Theodore Mauger, Committee Member, Lan Kong, Committee Member, Laura Carrel, Outside Member.

Subjects/Keywords: survival analysis; joint modeling; semi-competing risks; recurrent events; acute kidney injury; tri-vairate Weibull; acute kidney injury; tri-variate Weibull

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wang, L. (2016). The Joint Modeling of Recurrent Events and Other Failure Time Events. (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/xd07gs69t

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wang, Luojun. “The Joint Modeling of Recurrent Events and Other Failure Time Events.” 2016. Thesis, Penn State University. Accessed April 13, 2021. https://submit-etda.libraries.psu.edu/catalog/xd07gs69t.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wang, Luojun. “The Joint Modeling of Recurrent Events and Other Failure Time Events.” 2016. Web. 13 Apr 2021.

Vancouver:

Wang L. The Joint Modeling of Recurrent Events and Other Failure Time Events. [Internet] [Thesis]. Penn State University; 2016. [cited 2021 Apr 13]. Available from: https://submit-etda.libraries.psu.edu/catalog/xd07gs69t.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wang L. The Joint Modeling of Recurrent Events and Other Failure Time Events. [Thesis]. Penn State University; 2016. Available from: https://submit-etda.libraries.psu.edu/catalog/xd07gs69t

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Guelph

22. Bland, Susan Karlyn. Kidney Injury Molecule 1: A potential biomarker of renal injury in the cat.

Degree: Doctor of Veterinary Science, Department of Pathobiology, 2014, University of Guelph

URL: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8360

► The prevalence of both acute and chronic kidney disease in animals and people is increasing. Increased serum creatinine concentration indicates a decline in renal function… (more)

▼ The prevalence of both acute and chronic kidney disease in animals and people is increasing. Increased serum creatinine concentration indicates a decline in renal function but is insensitive for diagnosing acute kidney injury (AKI). As such, there is need to develop sensitive biomarkers of renal injury. At the fore in human medicine is a biomarker of acute renal tubular injury called kidney injury molecule-1 (KIM-1). KIM-1 is a cell membrane glycoprotein with an extracellular domain that is shed from proximal tubular kidney cells and detectable in urine after ischemic and toxic renal injury. KIM-1 was undetectable in normal human urine, but presence in urine correlated with immunohistochemical detection of KIM-1 in injured tubular epithelial cells. For these reasons, KIM-1 was considered a good candidate to investigate as a biomarker of kidney injury in cats. Alignment of KIM-1 sequences from human, rat, dog, and mice indicated a high degree of identity between species and conservation of a cytoplasmic tyrosine motif. Primers based on the conserved regions were used to amplify feline KIM-1 genomic and renal cDNA sequences. PCR assays used to amplify feline KIM-1 revealed the presence of three transcript variants derived by alternative splicing with exon-intron organization similar to KIM-1 orthologous sequences. KIM-1 was detected by IHC in tubules of the cortex and outer stripe of the outer medulla in cats with suspected naturally occurring AKI and cats with experimental unilateral ischemia/reperfusion. The same cells also expressed aquaporin 1, confirming expression of KIM-1 in the proximal convoluted tubules. Further, KIM-1 expression correlated positively with tubular injury scores and vimentin expression in the injured proximal tubules. Available urine immunoassay to rat Kim-1 yielded positive reactions with urine from 11 cats. In conclusion, feline KIM-1 is similar but not identical to human KIM-1. Expression is increased in cats with naturally occurring and experimental kidney injury, and KIM-1 may be detected in urine. KIM-1 is expressed predominantly in cells of the S3 segment of proximal tubules, and appears to persist during dedifferentiation and repair of injured cells. Hence, detection of KIM-1 in urine is a promising indicator of kidney injury in cats. Advisors/Committee Members: Bienzle, Dorothee (advisor).

Subjects/Keywords: kidney injury molecule-1 (KIM-1); cat; aquaporin 1; acute kidney injury (AKI); kidney disease; Immunohistochemistry

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bland, S. K. (2014). Kidney Injury Molecule 1: A potential biomarker of renal injury in the cat. (Doctoral Dissertation). University of Guelph. Retrieved from https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8360

Chicago Manual of Style (16^th Edition):

Bland, Susan Karlyn. “Kidney Injury Molecule 1: A potential biomarker of renal injury in the cat.” 2014. Doctoral Dissertation, University of Guelph. Accessed April 13, 2021. https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8360.

MLA Handbook (7^th Edition):

Bland, Susan Karlyn. “Kidney Injury Molecule 1: A potential biomarker of renal injury in the cat.” 2014. Web. 13 Apr 2021.

Vancouver:

Bland SK. Kidney Injury Molecule 1: A potential biomarker of renal injury in the cat. [Internet] [Doctoral dissertation]. University of Guelph; 2014. [cited 2021 Apr 13]. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8360.

Council of Science Editors:

Bland SK. Kidney Injury Molecule 1: A potential biomarker of renal injury in the cat. [Doctoral Dissertation]. University of Guelph; 2014. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8360

University of Minnesota

23. Li, Shuling. Association Between Adjuvant Chemotherapy and Nephrotoxicity and Kidney Function Monitoring in Elderly Breast Cancer Patients.

Degree: PhD, Epidemiology, 2013, University of Minnesota

URL: http://hdl.handle.net/11299/173925

► Background: Chronic kidney disease (CKD) and cancer are major public health problems in the elderly population. In elderly cancer patients, little is known about chemotherapy-related… (more)

▼ Background: Chronic kidney disease (CKD) and cancer are major public health problems in the elderly population. In elderly cancer patients, little is known about chemotherapy-related nephrotoxicity or patterns of CKD screening. The purpose of this dissertation was to evaluate the association between adjuvant chemotherapy (CHEMO) and risks of acute kidney injury (AKI) and CKD and rate of CKD screening in elderly women diagnosed with stages I-III breast cancer. Methods: The study was a 1:1 individually matched, retrospective cohort design using Surveillance, Epidemiology, and End Results (SEER)-Medicare linked data. Matching was performed at the day of CHEMO initiation based on propensity score. The assembled matched cohorts were used in the analyses for all three objectives with different follow-up periods and statistical methods for each objective. HASH(0x307f974) Results: A total of 28,048 patients were included. CHEMO was associated with a 2.7-fold increased risk of AKI within 6 months after initiation (HR 2.7, 95% CI 1.8-4.1). To find a possible explanation to this association, the distribution of other diseases coded on hospital claims for AKI was examined and showed that septicemia occurred in 40% of CHEMO treated patients with AKI and in only 17% of untreated patients with AKI. No significant association was found between CHEMO and risk of CKD in the maximum 18 years follow-up (HR 1.00, 95% CI 0.93-1.07). The rate of CKD screening after treatment completion was low regardless of CHEMO status. HASH(0x2faf9d4) Conclusion: CHEMO is associated with increased risk of AKI. This association may be partially explained by septicemia caused by infection/neutropenia due to use of myelosuppressive chemotherapeutic agents, which highlights the importance of preventing serious complications of CHEMO in preventing AKI. The finding of no association between CHEMO and risk of CKD may not suggest a late nephrotoxic effect of chemotherapeutic agents commonly used to treat breast cancer in the adjuvant setting, or provide evidence to recommend a clinical practice guideline for CKD screening specifically in elderly breast cancer patients treated with CHEMO. Future studies of CKD as a late effect of cancer treatment for other solid tumors commonly treated with known or potential nephrotoxic agents are warranted.

Subjects/Keywords: Acute kidney injury; Breast cancer; Chemotherapy; Chronic kidney disease; CKD screening; Nephrotoxicity

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Li, S. (2013). Association Between Adjuvant Chemotherapy and Nephrotoxicity and Kidney Function Monitoring in Elderly Breast Cancer Patients. (Doctoral Dissertation). University of Minnesota. Retrieved from http://hdl.handle.net/11299/173925

Chicago Manual of Style (16^th Edition):

Li, Shuling. “Association Between Adjuvant Chemotherapy and Nephrotoxicity and Kidney Function Monitoring in Elderly Breast Cancer Patients.” 2013. Doctoral Dissertation, University of Minnesota. Accessed April 13, 2021. http://hdl.handle.net/11299/173925.

MLA Handbook (7^th Edition):

Li, Shuling. “Association Between Adjuvant Chemotherapy and Nephrotoxicity and Kidney Function Monitoring in Elderly Breast Cancer Patients.” 2013. Web. 13 Apr 2021.

Vancouver:

Li S. Association Between Adjuvant Chemotherapy and Nephrotoxicity and Kidney Function Monitoring in Elderly Breast Cancer Patients. [Internet] [Doctoral dissertation]. University of Minnesota; 2013. [cited 2021 Apr 13]. Available from: http://hdl.handle.net/11299/173925.

Council of Science Editors:

Li S. Association Between Adjuvant Chemotherapy and Nephrotoxicity and Kidney Function Monitoring in Elderly Breast Cancer Patients. [Doctoral Dissertation]. University of Minnesota; 2013. Available from: http://hdl.handle.net/11299/173925

Louisiana State University

24. R. Nair, Anand. Toll-like Receptor 4 (TLR4) in Acute and Chronic Renal Diseases.

Degree: PhD, Medicine and Health Sciences, 2015, Louisiana State University

URL: etd-04062015-100633 ; https://digitalcommons.lsu.edu/gradschool_dissertations/3632

► Despite advances in its treatment, the incidence of renal diseases has been consistently increasing. Hence, there is a need to understand the underlying molecular mechanisms… (more)

▼ Despite advances in its treatment, the incidence of renal diseases has been consistently increasing. Hence, there is a need to understand the underlying molecular mechanisms of the progression of kidney diseases. Recent research implicates inflammation as an important mediator of renal injury. We hypothesized that inhibiting Toll-like receptor 4 (TLR4), an upstream modulator of several inflammatory pathways, would prevent the progression of renal diseases. First, we determined the mechanism by which AngiotensinII (AngII)-induced inflammation is modulated by TLR4 using an in vitro model of rat tubulo-epithelial cells. We blocked TLR4 using gene silencing strategy in NRK52E cells. In TLR4-silenced cells, the expression of TLR4 was decreased, activation of NF-κB was reduced, inflammation and oxidative stress were attenuated, suggesting a role for TLR4 in potentiating AngII-induced renal inflammation. We then focused on an in vivo acute kidney injury (AKI) model to elucidate the effect of TLR4 in AKI. We used lipopolysaccharide (LPS), a specific ligand of TLR4, to induce AKI. We injected one group of rats with VIPER, a TLR4 inhibitory peptide, before LPS administration. We also used blueberry as a non-pharmacological approach to study if blueberry could protect against LPS-induced AKI. Compared to LPS-administered rats, the BB-pretreated animals exhibited improved renal hemodynamics, attenuated expression of TLR4 and inflammation. The results in the BB-pretreated group were consistent with the VIPER-treated rats. This indicates that TLR4 is an important mediator in LPS-induced AKI, and suggest that BB, by inhibiting TLR4, is a viable non-pharmacological option to decrease AKI. We also examined the effect of TLR4 signaling and its downstream mechanism in an animal model of metabolic syndrome-associated chronic kidney disease (CKD) and investigated if a blueberry-enriched diet could attenuate the progression of CKD. We showed that OZR exhibited lower glucose tolerance, exacerbated renal dysfunction and increased oxidative stress. Expression levels of TLR4 and, phosphorylation of ERK and p38MAPK were higher. This was accompanied by increased renal pathology. BB-fed OZR showed significant improvements in all of these parameters. This suggests that the TLR4-MAPK signaling pathway is a key to the renal dysfunction in MetS, and BB protects against this damage by inhibiting TLR4.

Subjects/Keywords: acute kidney injury; chronic kidney disease; renal disease; inflammation; TLR4; oxidative stress

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APA (6^th Edition):

R. Nair, A. (2015). Toll-like Receptor 4 (TLR4) in Acute and Chronic Renal Diseases. (Doctoral Dissertation). Louisiana State University. Retrieved from etd-04062015-100633 ; https://digitalcommons.lsu.edu/gradschool_dissertations/3632

Chicago Manual of Style (16^th Edition):

R. Nair, Anand. “Toll-like Receptor 4 (TLR4) in Acute and Chronic Renal Diseases.” 2015. Doctoral Dissertation, Louisiana State University. Accessed April 13, 2021. etd-04062015-100633 ; https://digitalcommons.lsu.edu/gradschool_dissertations/3632.

MLA Handbook (7^th Edition):

R. Nair, Anand. “Toll-like Receptor 4 (TLR4) in Acute and Chronic Renal Diseases.” 2015. Web. 13 Apr 2021.

Vancouver:

R. Nair A. Toll-like Receptor 4 (TLR4) in Acute and Chronic Renal Diseases. [Internet] [Doctoral dissertation]. Louisiana State University; 2015. [cited 2021 Apr 13]. Available from: etd-04062015-100633 ; https://digitalcommons.lsu.edu/gradschool_dissertations/3632.

Council of Science Editors:

R. Nair A. Toll-like Receptor 4 (TLR4) in Acute and Chronic Renal Diseases. [Doctoral Dissertation]. Louisiana State University; 2015. Available from: etd-04062015-100633 ; https://digitalcommons.lsu.edu/gradschool_dissertations/3632

University of Louisville

25. Sears, Sophia M. Characterizing the roles of neutral ceramidase in cisplatin-induced kidney injury.

Degree: MS, 2019, University of Louisville

URL: https://ir.library.louisville.edu/etd/3396

► Cisplatin is a commonly used chemotherapeutic agent with a dose-limiting nephrotoxicity. 30% of patients given cisplatin develop acute kidney injury (AKI). AKI increases risk… (more)

Subjects/Keywords: Cisplatin; neutral ceramidase; acute kidney injury; chronic kidney disease; Pharmacology, Toxicology and Environmental Health

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APA (6^th Edition):

Sears, S. M. (2019). Characterizing the roles of neutral ceramidase in cisplatin-induced kidney injury. (Masters Thesis). University of Louisville. Retrieved from https://ir.library.louisville.edu/etd/3396

Chicago Manual of Style (16^th Edition):

Sears, Sophia M. “Characterizing the roles of neutral ceramidase in cisplatin-induced kidney injury.” 2019. Masters Thesis, University of Louisville. Accessed April 13, 2021. https://ir.library.louisville.edu/etd/3396.

MLA Handbook (7^th Edition):

Sears, Sophia M. “Characterizing the roles of neutral ceramidase in cisplatin-induced kidney injury.” 2019. Web. 13 Apr 2021.

Vancouver:

Sears SM. Characterizing the roles of neutral ceramidase in cisplatin-induced kidney injury. [Internet] [Masters thesis]. University of Louisville; 2019. [cited 2021 Apr 13]. Available from: https://ir.library.louisville.edu/etd/3396.

Council of Science Editors:

Sears SM. Characterizing the roles of neutral ceramidase in cisplatin-induced kidney injury. [Masters Thesis]. University of Louisville; 2019. Available from: https://ir.library.louisville.edu/etd/3396

University of Otago

26. Md Ralib, Azrina. Acute Kidney Injury in the Intensive Care Unit: Prediction of Severity and Outcome .

Degree: 2013, University of Otago

URL: http://hdl.handle.net/10523/4216

► Acute Kidney Injury (AKI) is common and contributes to high mortality amongst critically ill patients. The overall aim of this project was to investigate functional… (more)

▼ Acute Kidney Injury (AKI) is common and contributes to high mortality amongst critically ill patients. The overall aim of this project was to investigate functional and structural biomarkers for AKI detection and prediction of its severity and outcome in critically ill patients. The role of current available diagnostic tools, which include plasma creatinine, and urine output, and new emerging AKI biomarkers such as plasma and urinary Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Cystatin C (CysC), urinary γ-Glutamyl Transpeptidase (GGT), Alkaline Phosphatase (AP), α- and π-Glutyamyl S-Transferase (GST), and albumin were investigated. Normalisation of urinary biomarker concentrations to urinary creatinine concentration is commonly used to account for variations in water reabsorption. The accuracy of this method is compromised by tubular secretion of creatinine and variations in urinary creatinine excretion in non-steady state when GFR changes. Alternatives include using the absolute concentration or quantifying the excretion rate. We compared these in post-hoc analysis of 484 ICU patients, in chapter 3. Absolute concentration performed best for diagnosis of AKI on admission, but normalised concentrations performed best for prediction of mortality, dialysis or subsequent development of AKI. Excretion rate did not diagnose or predict outcomes better than absolute or normalised concentration, but the total biomarker excretion over 24 hours was associated with AKI severity and poorer survival, hence may be useful as outcome variables in clinical trials of AKI. AKI biomarkers promise earlier diagnosis. However, their performances are influenced by the duration from insult until time of measurement. Earlier measurement of biomarkers following insult may better diagnose AKI compared to later measurement. This was investigated in 77 patients following cardiac arrest, sustained or profound hypotension or ruptured abdominal aortic aneurysm, in chapter 4. Almost 60% of patients had AKI. Early measurement of biomarkers in the ED did not improve their AKI diagnostic performance. Biomarker ability to predict the composite outcome of mortality or dialysis was also assessed. Of the biomarkers measured, urinary NGAL independently predicted mortality or dialysis, and modestly improved the risk prediction model. The temporal profile of plasma creatinine following insult was investigated in 77 patients, in chapter 5. Plasma creatinine increases were sufficient to diagnose AKI in almost 60% of patients, most on ED arrival within less than two hours of the event. Loss of filtration function alone could not account for this early increase in plasma creatinine. Other factors such as increased creatinine production, or redistribution need to be considered. Creatinine measurement during the early period following insult should not be utilised as a baseline as this is likely to underdiagnose AKI. In 40% of AKI patients, plasma creatinine decreased below the AKI threshold within 48 hours. Even with transient loss of filtration… Advisors/Committee Members: Endre, Zoltan (advisor).

Subjects/Keywords: Acute Kidney Injury; Biomarker; Fluid Balance; Urine Output

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Md Ralib, A. (2013). Acute Kidney Injury in the Intensive Care Unit: Prediction of Severity and Outcome . (Doctoral Dissertation). University of Otago. Retrieved from http://hdl.handle.net/10523/4216

Chicago Manual of Style (16^th Edition):

Md Ralib, Azrina. “Acute Kidney Injury in the Intensive Care Unit: Prediction of Severity and Outcome .” 2013. Doctoral Dissertation, University of Otago. Accessed April 13, 2021. http://hdl.handle.net/10523/4216.

MLA Handbook (7^th Edition):

Md Ralib, Azrina. “Acute Kidney Injury in the Intensive Care Unit: Prediction of Severity and Outcome .” 2013. Web. 13 Apr 2021.

Vancouver:

Md Ralib A. Acute Kidney Injury in the Intensive Care Unit: Prediction of Severity and Outcome . [Internet] [Doctoral dissertation]. University of Otago; 2013. [cited 2021 Apr 13]. Available from: http://hdl.handle.net/10523/4216.

Council of Science Editors:

Md Ralib A. Acute Kidney Injury in the Intensive Care Unit: Prediction of Severity and Outcome . [Doctoral Dissertation]. University of Otago; 2013. Available from: http://hdl.handle.net/10523/4216

University of Minnesota

27. Afshinnia, Farsad. An optimized classification system of acute kidney injury for predicting the short-term mortality after open heart surgery; comparison of current classification systems.

Degree: MS, Clinical Research, 2010, University of Minnesota

URL: http://purl.umn.edu/91993

►

University of Minnesota M.S. thesis. May 2010. Major: Clinical Research. Advisor: Hassan N. Ibrahim MD, MS. 1 computer file (PDF); vii, 66 pages, appendices 1-14.… (more)

Subjects/Keywords: Acute kidney injury; Epidemiologic studies; Mortality; Clinical Research

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Afshinnia, F. (2010). An optimized classification system of acute kidney injury for predicting the short-term mortality after open heart surgery; comparison of current classification systems. (Masters Thesis). University of Minnesota. Retrieved from http://purl.umn.edu/91993

Chicago Manual of Style (16^th Edition):

Afshinnia, Farsad. “An optimized classification system of acute kidney injury for predicting the short-term mortality after open heart surgery; comparison of current classification systems.” 2010. Masters Thesis, University of Minnesota. Accessed April 13, 2021. http://purl.umn.edu/91993.

MLA Handbook (7^th Edition):

Afshinnia, Farsad. “An optimized classification system of acute kidney injury for predicting the short-term mortality after open heart surgery; comparison of current classification systems.” 2010. Web. 13 Apr 2021.

Vancouver:

Afshinnia F. An optimized classification system of acute kidney injury for predicting the short-term mortality after open heart surgery; comparison of current classification systems. [Internet] [Masters thesis]. University of Minnesota; 2010. [cited 2021 Apr 13]. Available from: http://purl.umn.edu/91993.

Council of Science Editors:

Afshinnia F. An optimized classification system of acute kidney injury for predicting the short-term mortality after open heart surgery; comparison of current classification systems. [Masters Thesis]. University of Minnesota; 2010. Available from: http://purl.umn.edu/91993

Vanderbilt University

28. Smith, Derek Kyle. Empirical Bayes Methods for Everyday Statistical Problems.

Degree: PhD, Biostatistics, 2017, Vanderbilt University

URL: http://hdl.handle.net/1803/15344

► This work develops an empirical Bayes approach to statistical difficulties that arise in real-world applications. Empirical Bayes methods use Bayesian machinery to obtain statistical estimates,… (more)

▼ This work develops an empirical Bayes approach to statistical difficulties that arise in real-world applications. Empirical Bayes methods use Bayesian machinery to obtain statistical estimates, but rather than having a prior distribution for model parameters that is assumed, the prior is estimated from the observed data. Misuse of these methods as though the resulting “posterior distributions” were true Bayes posteriors has lead to limited adoption, but careful application can result in improved point estimation in a wide variety of circumstances. The first problem solved via an empirical Bayes approach deals with surrogate outcome measures. Theory for using surrogate outcomes for inference in clinical trials has been developed over the last 30 years starting with the development of the Prentice criteria for surrogate outcomes in 1989. Theory for using surrogates outside of the clinical trials arena or to develop risk score models is lacking. In this work we propose criteria similar to the Prentice criteria for using surrogates to develop risk scores. We then identify a particular type of surrogate which violates the proposed criteria in a particular way, which we deem a partial surrogate. The behavior of partial surrogates is investigated through a series of simulation studies and an empirical Bayes weighting scheme is developed which alleviates their pathologic behavior. It is then hypothesized that a common clinical measure, change in perioperative serum creatinine level from baseline, is actually a partial surrogate. It is demonstrated that it displays the same sort of pathologic behaviors seen in the simulation study and that they are similarly rectified using the proposed method. The result is a more acurate predictive model for both short and long-term measure of kidney function. The second problem solved deals with likelihood support intervals. Likelihood intervals are a way to quantify statistical uncertainty. Unlike other, more common methods for interval estimation, every value that is included in a support interval must be supported by the data at a specified level. Support intervals have not seen wide usage in practice due to a philosophic belief amongst many in the field that frequency-based or probabilistic inference is somehow stronger than inference based soley on the likelihood. In this work we develop a novel procedure based on the bootstrap for estimating the frequency characteristics of likelihood intervals. The resulting intervals have both the frequency properties of the set prized by frequentists as well as each individual member of the set attaining a specified support level. An R package, supportInt, was developed to calculate these intervals and published on the Comprehensive R Archive Network. The third problem addressed deals with the design of clinical trials when the potential protocols for the intervention are highly variable. A meta-analysis is presented in which the difficulties this situation presents becomes apparent. The results of this analysis of randomized trials of… Advisors/Committee Members: Jeffrey Blume (committee member), Sonya Sterba (committee member), Robert Greevy (committee member), William Dupont (Committee Chair).

Subjects/Keywords: empirical bayes; shrinkage; probabilistic calibration; clinical trial design; acute kidney injury

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APA (6^th Edition):

Smith, D. K. (2017). Empirical Bayes Methods for Everyday Statistical Problems. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/15344

Chicago Manual of Style (16^th Edition):

Smith, Derek Kyle. “Empirical Bayes Methods for Everyday Statistical Problems.” 2017. Doctoral Dissertation, Vanderbilt University. Accessed April 13, 2021. http://hdl.handle.net/1803/15344.

MLA Handbook (7^th Edition):

Smith, Derek Kyle. “Empirical Bayes Methods for Everyday Statistical Problems.” 2017. Web. 13 Apr 2021.

Vancouver:

Smith DK. Empirical Bayes Methods for Everyday Statistical Problems. [Internet] [Doctoral dissertation]. Vanderbilt University; 2017. [cited 2021 Apr 13]. Available from: http://hdl.handle.net/1803/15344.

Council of Science Editors:

Smith DK. Empirical Bayes Methods for Everyday Statistical Problems. [Doctoral Dissertation]. Vanderbilt University; 2017. Available from: http://hdl.handle.net/1803/15344

Boston University

29. Vemula, Pradheep. Manipulation of Mitofusin2/Ras interaction as a therapy for acute ischemic kidney injury.

Degree: MS, Medical Sciences, 2014, Boston University

URL: http://hdl.handle.net/2144/15346

► Mitofusin 2 (MFN2), an outer mitochondrial membrane protein expressed in virtually all human tissues, is a multi-faceted protein known to affect mitochondrial morphology, metabolism, tethering,… (more)

Subjects/Keywords: Molecular biology; Mitofusin 2; Acute kidney injury; Hyperplasia suppressor gene

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APA (6^th Edition):

Vemula, P. (2014). Manipulation of Mitofusin2/Ras interaction as a therapy for acute ischemic kidney injury. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/15346

Chicago Manual of Style (16^th Edition):

Vemula, Pradheep. “Manipulation of Mitofusin2/Ras interaction as a therapy for acute ischemic kidney injury.” 2014. Masters Thesis, Boston University. Accessed April 13, 2021. http://hdl.handle.net/2144/15346.

MLA Handbook (7^th Edition):

Vemula, Pradheep. “Manipulation of Mitofusin2/Ras interaction as a therapy for acute ischemic kidney injury.” 2014. Web. 13 Apr 2021.

Vancouver:

Vemula P. Manipulation of Mitofusin2/Ras interaction as a therapy for acute ischemic kidney injury. [Internet] [Masters thesis]. Boston University; 2014. [cited 2021 Apr 13]. Available from: http://hdl.handle.net/2144/15346.

Council of Science Editors:

Vemula P. Manipulation of Mitofusin2/Ras interaction as a therapy for acute ischemic kidney injury. [Masters Thesis]. Boston University; 2014. Available from: http://hdl.handle.net/2144/15346

University of Toronto

30. Kitchlu, Abhijat. Acute Kidney Injury in Patients Receiving Systemic Treatment for Cancer: A Population-based Cohort Study.

Degree: 2019, University of Toronto

URL: http://hdl.handle.net/1807/94029

►

Background: Patients undergoing cancer treatment are at increased risk of acute kidney injury (AKI), but there are few data on incidence and risk factors. Methods:… (more)

Subjects/Keywords: Acute Kidney Injury; Cancer; Dialysis; Nephrology; Systemic Treatment; Toxicity; 0564

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APA (6^th Edition):

Kitchlu, A. (2019). Acute Kidney Injury in Patients Receiving Systemic Treatment for Cancer: A Population-based Cohort Study. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/94029

Chicago Manual of Style (16^th Edition):

Kitchlu, Abhijat. “Acute Kidney Injury in Patients Receiving Systemic Treatment for Cancer: A Population-based Cohort Study.” 2019. Masters Thesis, University of Toronto. Accessed April 13, 2021. http://hdl.handle.net/1807/94029.

MLA Handbook (7^th Edition):

Kitchlu, Abhijat. “Acute Kidney Injury in Patients Receiving Systemic Treatment for Cancer: A Population-based Cohort Study.” 2019. Web. 13 Apr 2021.

Vancouver:

Kitchlu A. Acute Kidney Injury in Patients Receiving Systemic Treatment for Cancer: A Population-based Cohort Study. [Internet] [Masters thesis]. University of Toronto; 2019. [cited 2021 Apr 13]. Available from: http://hdl.handle.net/1807/94029.

Council of Science Editors:

Kitchlu A. Acute Kidney Injury in Patients Receiving Systemic Treatment for Cancer: A Population-based Cohort Study. [Masters Thesis]. University of Toronto; 2019. Available from: http://hdl.handle.net/1807/94029

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Open Access Theses and Dissertations