subject:(acute kidney injury AKI )

University of Manchester

1. Sykes, Lynne Frances. Assessing the impact of acute kidney injury in secondary care and developing strategies to improve outcomes.

Degree: 2020, University of Manchester

URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:323391

► Assessing the impact of acute kidney injury in secondary care and developing strategies to improve outcomes (Dr Lynne Sykes) Introduction: Acute kidney injury (AKI) is… (more)

Subjects/Keywords: AKI; acute kidney injury; quality improvement; acute renal failure

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APA (6^th Edition):

Sykes, L. F. (2020). Assessing the impact of acute kidney injury in secondary care and developing strategies to improve outcomes. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:323391

Chicago Manual of Style (16^th Edition):

Sykes, Lynne Frances. “Assessing the impact of acute kidney injury in secondary care and developing strategies to improve outcomes.” 2020. Doctoral Dissertation, University of Manchester. Accessed March 05, 2021. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:323391.

MLA Handbook (7^th Edition):

Sykes, Lynne Frances. “Assessing the impact of acute kidney injury in secondary care and developing strategies to improve outcomes.” 2020. Web. 05 Mar 2021.

Vancouver:

Sykes LF. Assessing the impact of acute kidney injury in secondary care and developing strategies to improve outcomes. [Internet] [Doctoral dissertation]. University of Manchester; 2020. [cited 2021 Mar 05]. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:323391.

Council of Science Editors:

Sykes LF. Assessing the impact of acute kidney injury in secondary care and developing strategies to improve outcomes. [Doctoral Dissertation]. University of Manchester; 2020. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:323391

University of Guelph

2. Bland, Susan Karlyn. Kidney Injury Molecule 1: A potential biomarker of renal injury in the cat.

Degree: Doctor of Veterinary Science, Department of Pathobiology, 2014, University of Guelph

URL: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8360

► The prevalence of both acute and chronic kidney disease in animals and people is increasing. Increased serum creatinine concentration indicates a decline in renal function… (more)

▼ The prevalence of both acute and chronic kidney disease in animals and people is increasing. Increased serum creatinine concentration indicates a decline in renal function but is insensitive for diagnosing acute kidney injury (AKI). As such, there is need to develop sensitive biomarkers of renal injury. At the fore in human medicine is a biomarker of acute renal tubular injury called kidney injury molecule-1 (KIM-1). KIM-1 is a cell membrane glycoprotein with an extracellular domain that is shed from proximal tubular kidney cells and detectable in urine after ischemic and toxic renal injury. KIM-1 was undetectable in normal human urine, but presence in urine correlated with immunohistochemical detection of KIM-1 in injured tubular epithelial cells. For these reasons, KIM-1 was considered a good candidate to investigate as a biomarker of kidney injury in cats. Alignment of KIM-1 sequences from human, rat, dog, and mice indicated a high degree of identity between species and conservation of a cytoplasmic tyrosine motif. Primers based on the conserved regions were used to amplify feline KIM-1 genomic and renal cDNA sequences. PCR assays used to amplify feline KIM-1 revealed the presence of three transcript variants derived by alternative splicing with exon-intron organization similar to KIM-1 orthologous sequences. KIM-1 was detected by IHC in tubules of the cortex and outer stripe of the outer medulla in cats with suspected naturally occurring AKI and cats with experimental unilateral ischemia/reperfusion. The same cells also expressed aquaporin 1, confirming expression of KIM-1 in the proximal convoluted tubules. Further, KIM-1 expression correlated positively with tubular injury scores and vimentin expression in the injured proximal tubules. Available urine immunoassay to rat Kim-1 yielded positive reactions with urine from 11 cats. In conclusion, feline KIM-1 is similar but not identical to human KIM-1. Expression is increased in cats with naturally occurring and experimental kidney injury, and KIM-1 may be detected in urine. KIM-1 is expressed predominantly in cells of the S3 segment of proximal tubules, and appears to persist during dedifferentiation and repair of injured cells. Hence, detection of KIM-1 in urine is a promising indicator of kidney injury in cats. Advisors/Committee Members: Bienzle, Dorothee (advisor).

Subjects/Keywords: kidney injury molecule-1 (KIM-1); cat; aquaporin 1; acute kidney injury (AKI); kidney disease; Immunohistochemistry

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APA (6^th Edition):

Bland, S. K. (2014). Kidney Injury Molecule 1: A potential biomarker of renal injury in the cat. (Doctoral Dissertation). University of Guelph. Retrieved from https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8360

Chicago Manual of Style (16^th Edition):

Bland, Susan Karlyn. “Kidney Injury Molecule 1: A potential biomarker of renal injury in the cat.” 2014. Doctoral Dissertation, University of Guelph. Accessed March 05, 2021. https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8360.

MLA Handbook (7^th Edition):

Bland, Susan Karlyn. “Kidney Injury Molecule 1: A potential biomarker of renal injury in the cat.” 2014. Web. 05 Mar 2021.

Vancouver:

Bland SK. Kidney Injury Molecule 1: A potential biomarker of renal injury in the cat. [Internet] [Doctoral dissertation]. University of Guelph; 2014. [cited 2021 Mar 05]. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8360.

Council of Science Editors:

Bland SK. Kidney Injury Molecule 1: A potential biomarker of renal injury in the cat. [Doctoral Dissertation]. University of Guelph; 2014. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8360

University of Ghana

3. Wemakor, I.S. Risk Factors For Postoperative Acute Kidney Injury (AKI) Following Laparotomy For Abdominal Emergencies At The Korle- Bu Teaching Hospital .

Degree: 2016, University of Ghana

URL: http://ugspace.ug.edu.gh/handle/123456789/22826

► Background: Postoperative acute kidney injury (AKI) is associated with increased morbidity, cost, prolonged hospital stay, and greater than 50% mortality rate in abdominal surgery. Among… (more)

▼ Background: Postoperative acute kidney injury (AKI) is associated with increased morbidity, cost, prolonged hospital stay, and greater than 50% mortality rate in abdominal surgery. Among abdominal procedures, open surgical technique has the highest risk of postoperative AKI as compared to the laparoscopic approach. Postoperative AKI is a common condition in laparotomy patients. In patients with emergency abdominal conditions, laparotomy offers the only chance for cure. Various complications (such as pneumonia, wound infection, deep vein thrombosis, and impaired renal function) occur in these patients. However, the risk factors for postoperative acute kidney injury (AKI) and its effects on the clinical outcomes at the Korle-Bu Teaching Hospital are not well understood. There is therefore the need to collate data General Aim: To determine the incidence and risk factors of postoperative AKI following laparotomy for abdominal emergencies in patients with previously normal renal function at the Korle-Bu Teaching Hospital. Methodology: This was a prospective cohort study that was carried out on 200 patients undergoing emergency (100 patients) and elective (100 patients) laparotomy following abdominal emergencies at the surgical department of Korle Bu Teaching Hospital from June 2015 to June 2016 with a mean age of (41± 17.41) years. Five (5) mls of venous blood sample was drawn from each patient pre and post operation. Serum urea, nitrogen and creatinine were determined by modified Jaffe reaction method using Pentra C200 auto analyzer. Serum Potassium, Chloride and Sodium levels were determined using a flow technique by an Idexx VetLyte electrolyte auto analyzer. Full blood count was determined by an automated Mindary BC-6800 haematology analyzer. The 24 hours post-operative urine output was measured using a calibrated urine cup. Blood pressure was measured using an osillometric Omron device validated in adults while a digital thermometer was used in measuring body temperature. An Omron digital scale was also used to measure patient weight. Using the ratio of blood urea nitrogen (BUN, mg/dl) over serum creatinine level (Cr, mg/dl) as a marker of relative renal function and KDIGO classification which define postoperative AKI as an increase in absolute serum creatinine of at least 0.3 mg/dL or by a percentual increase in serum creatinine equal to or higher than 50% (1.5X baseline value) and/or by a decrease in urine output lower than 0.5 mL/kg/hour for more than 6 hours. Results: The mean age of the 200 patients who underwent laparotomy was 41±17.41 years; the majority of the patients were males 133 (66.5 %) while 67 (33.5%) were females. The incidence of postoperative AKI following laparotomy is approximately is 4.5%. Multivariate analysis using logistic regression was performed to quantify the association of BUN/Cr ratio with AKI. The development of postoperative AKI was significantly associated with advanced age (p=0.01), emergency laparotomy (p=0.02), pre-operative anaemia (p=0.01) an adjusted R-Square of 0.286…

Subjects/Keywords: Postoperative Acute Kidney Injury (AKI); Laparotomy; Abdominal Emergencies; Korle- Bu Teaching Hospital; Ghana

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wemakor, I. S. (2016). Risk Factors For Postoperative Acute Kidney Injury (AKI) Following Laparotomy For Abdominal Emergencies At The Korle- Bu Teaching Hospital . (Masters Thesis). University of Ghana. Retrieved from http://ugspace.ug.edu.gh/handle/123456789/22826

Chicago Manual of Style (16^th Edition):

Wemakor, I S. “Risk Factors For Postoperative Acute Kidney Injury (AKI) Following Laparotomy For Abdominal Emergencies At The Korle- Bu Teaching Hospital .” 2016. Masters Thesis, University of Ghana. Accessed March 05, 2021. http://ugspace.ug.edu.gh/handle/123456789/22826.

MLA Handbook (7^th Edition):

Wemakor, I S. “Risk Factors For Postoperative Acute Kidney Injury (AKI) Following Laparotomy For Abdominal Emergencies At The Korle- Bu Teaching Hospital .” 2016. Web. 05 Mar 2021.

Vancouver:

Wemakor IS. Risk Factors For Postoperative Acute Kidney Injury (AKI) Following Laparotomy For Abdominal Emergencies At The Korle- Bu Teaching Hospital . [Internet] [Masters thesis]. University of Ghana; 2016. [cited 2021 Mar 05]. Available from: http://ugspace.ug.edu.gh/handle/123456789/22826.

Council of Science Editors:

Wemakor IS. Risk Factors For Postoperative Acute Kidney Injury (AKI) Following Laparotomy For Abdominal Emergencies At The Korle- Bu Teaching Hospital . [Masters Thesis]. University of Ghana; 2016. Available from: http://ugspace.ug.edu.gh/handle/123456789/22826

Freie Universität Berlin

4. Ott, Sascha. Influence of mixed respiratory-metabolic acidemia on renal physiology and morphology.

Degree: 2017, Freie Universität Berlin

URL: https://refubium.fu-berlin.de/handle/fub188/13338

► Introduction: Despite major advances in renal replacement therapy acute kidney injury (AKI) is still associated with high morbidity and mortality. Beside risk factors like mechanical… (more)

▼ Introduction: Despite major advances in renal replacement therapy acute kidney injury (AKI) is still associated with high morbidity and mortality. Beside risk factors like mechanical ventilation, acidosis has been identified as one factor contributing to AKI. However, in critically ill patients with multiple risk factors a differentiated analysis of the influence of acidosis is hard to perform. Therefore, the aim of our study was to evaluate the impact of an acidaemia on renal function excluding sepsis or other infections. Methods: 35 young and healthy pigs were randomized into 6 groups. Three test pairs were settled with or without exposition to a continuos veno-venous haemofiltration (CVVH), respectively. The groups differed by: normoxaemia-balanced acid-base- status (NB-CVVH and NB-CTRL), normoxaemia-acidaemic (NA-CVVH and NA-CTRL) and hypoxaemia-acidaemic (HA-CVVH and HA-CTRL). Due to low-tidal-volume- ventilation and acid-infusion a mixed acidaemia (pH 7.19-7.24) was induced into acidaemic groups. HA-groups underwent an additional hypoxaemia. Acidemia and hypoxaemia were maintained for five hours. Haemodynamics, ventilation parameter, blood gas analysis and diuresis were monitored constantly as well as interleukin-6 (IL-6), TNF-aplha and interleukin-18 (IL-18) in blood and tissue samples, neutrophil gelatinase-associated lipocalin (NGAL) was analyzed in urine specimen. Tissue samples of the kidneys were (immuno-) histologically examined. Results: All animals were haemodynamically stable throughout the entire experiment. Animals had sufficient diuresis facing a physiologic cardiac output at any time. Interestingly, diuresis increased in acidemia groups while urine-pH decreased. Increased plasma levels of IL-18 and NGAL indicated a developing AKI in the acidaemia groups. Concordantly, normoxic- acidaemia groups had significantly more reversible and irreversible cell damage in histopathological examination, just exceeded by hypoxaemia- acidaemia groups. Due to measurements of proinflammatory cytokines in tissue and plasma a biotrauma induced AKI was excluded, because subgroup analysis of immunohistology revealed an inverse correlation between tissue levels of proinflammatory cytokines and histopathological cell damage. Conclusion: We were able to demonstrate that an isolated acidaemia without concomitant sepsis already leads to a relevant histologically detectable damage of the kidneys after only five hours exposition to acidaemia. Immunohistochemical investigations showed that other than inflammatory factors induced the renal damage. Results are leading to the hypothesis that the acidaemia works as a kind of „first hit“ by increasing renal workload with respect to the correction of acid-base-status abnormalities and thereby contributing to a depletion of renal energy reserves. Initially increasing diuresis clinically masks the early onset of an AKI due to the compensation for acidosis by the kidneys. Advisors/Committee Members: [email protected] (contact), m (gender), N.N. (firstReferee), N.N. (furtherReferee).

Subjects/Keywords: kidney; acidemia; acid-base-status; acute kidney injury (AKI);

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ott, S. (2017). Influence of mixed respiratory-metabolic acidemia on renal physiology and morphology. (Thesis). Freie Universität Berlin. Retrieved from https://refubium.fu-berlin.de/handle/fub188/13338

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ott, Sascha. “Influence of mixed respiratory-metabolic acidemia on renal physiology and morphology.” 2017. Thesis, Freie Universität Berlin. Accessed March 05, 2021. https://refubium.fu-berlin.de/handle/fub188/13338.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ott, Sascha. “Influence of mixed respiratory-metabolic acidemia on renal physiology and morphology.” 2017. Web. 05 Mar 2021.

Vancouver:

Ott S. Influence of mixed respiratory-metabolic acidemia on renal physiology and morphology. [Internet] [Thesis]. Freie Universität Berlin; 2017. [cited 2021 Mar 05]. Available from: https://refubium.fu-berlin.de/handle/fub188/13338.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ott S. Influence of mixed respiratory-metabolic acidemia on renal physiology and morphology. [Thesis]. Freie Universität Berlin; 2017. Available from: https://refubium.fu-berlin.de/handle/fub188/13338

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

5. Zhu, Ye. Rolle von Cytochrom P450 (CYP) -abhängigen Eicosanoide bei der experimentellen akuten Nierenschädigung (AKI).

Degree: 2015, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-6041

► Hintergrund und Hypothese: Ischämie-bedingtes akutes Nierenversagen (ANV) kann als schwerwiegende Komplikation in verschiedenen klinischen Situationen auftreten und führt zu erhöhter Morbidität und Mortalität der Patienten.… (more)

▼ Hintergrund und Hypothese: Ischämie-bedingtes akutes Nierenversagen (ANV) kann als schwerwiegende Komplikation in verschiedenen klinischen Situationen auftreten und führt zu erhöhter Morbidität und Mortalität der Patienten. Zur Entwicklung neuer therapeutischer Ansätze wird in der vorliegenden Arbeit die Rolle von Cytochrom P450 (CYP)-abhängigen Eicosanoiden bei der Entstehung des ANV untersucht. Zu diesen Eicosanoiden gehören 20-Hydroxyeicosatetraensäure (20-HETE) und Epoxyeicosatriensäuren (EETs), welche als Gegenspieler bei der Regulation des Gefäßtonus, Inflammation und Apoptose fungieren. Mittels pharmakologischer und genetischer Interventionen wurde die Hypothese untersucht, ob durch Verstärkung der EET-Wirkung die Auswirkungen des akutem Nierenversagens abgemildert werden können. Experimentelles Design und Methoden: Zunächst wurde die Wirkung eines synthetischen EET-Analogons auf den renalen Ischämie/Reperfusions (I/R)-Schaden bei der Ratte untersucht. In einer zweiten Versuchsreihe wurden Wildtyp (WT)- und Knockout (KO)-Mäuse für das Enzym lösliche Epoxidhydrolase (sEH) (sEH-KO-Mäuse) eingesetzt, um die Effekte eines verminderten EET-Abbaus auf den Schweregrad des I/R-induzierten Nierenschadens zu analysieren. Das Ausmaß des Nierenschadens wurde anhand funktioneller und histomorphologischer Parameter bewertet, nach dem die Tiere einer renalen Ischämie (45 Minuten in Ratten, 22 Minuten in Mäusen) gefolgt von einer zweitägigen Beobachtungsphase nach Reperfusion unterworfen wurden. Die CYP-Eicosanoide wurden mittels Flüssigchromatographie Tandem- Massenspektrometrie bestimmt. Ergebnisse: In der Rattenniere kam es während der Ischämie zu einer gesteigerten Freisetzung von 20-HETE, während eine vermehrte EET-Bildung ausblieb. Die Gabe eines EET-Analogons vor Ischämie führte zu einer signifikanten Verminderung des I/R-induzierten renalen Funktionsverlusts, der tubulären Apoptose sowie der Infiltration von Entzündungszellen. Im Gegensatz zur Ausgangshypothese, zeigten sEH-KO Tiere einen größeren Nierenfunktionsverlust als WT-Tiere. Auch das Ausmaß des tubulären Schadens, sowie der tubulären Apoptose und der inflammtorischen Gewebsreaktion war in den sEH-KO Tieren signifikant stärker als in den Wildtypmäusen. Auf metabolischer Ebene führte der sEH-KO wie erwartetet zur Erhöhung der endogenen EET-Spiegel in allen untersuchten Geweben (Niere, Leber und Plasma). Zugleich wiesen die sEH-KO Tiere jedoch auch einen erhöhten 20 -HETE-Gehalt im Nierengewebe aber nicht in Plasma und Leber auf. Die erhöhten renalen 20-HETE-Spiegel korrelierten mit einer verstärkten mRNA und Protein Expression von Cyp4a12a, der murinen 20-HETE-Synthase, sowie einer erhöhten immunhistochemischesn Cyp4a12a-Expression in Nierengefäßen bei sEH-KO Mäusen. Diese Ergebnisse deuten darauf hin, dass der potenziell schützende Effekt des verminderten EET-Abbaus durch eine Nieren-spezifische Steigerung der 20-HETE- Bildung in sEH-KO Mäusen aufgehoben wurde. Zusammenfassung: Die Ergebnisse aus beiden Tiermodellen zeigen, dass eine Imbalanz zwischen 20-HETE… Advisors/Committee Members: [email protected] (contact), w (gender), N.N. (firstReferee), N.N. (furtherReferee).

Subjects/Keywords: cytochrome P450 (CYP); dependent eicosanoids; acute kidney injury (AKI); 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zhu, Y. (2015). Rolle von Cytochrom P450 (CYP) -abhängigen Eicosanoide bei der experimentellen akuten Nierenschädigung (AKI). (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-6041

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Zhu, Ye. “Rolle von Cytochrom P450 (CYP) -abhängigen Eicosanoide bei der experimentellen akuten Nierenschädigung (AKI).” 2015. Thesis, Freie Universität Berlin. Accessed March 05, 2021. http://dx.doi.org/10.17169/refubium-6041.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Zhu, Ye. “Rolle von Cytochrom P450 (CYP) -abhängigen Eicosanoide bei der experimentellen akuten Nierenschädigung (AKI).” 2015. Web. 05 Mar 2021.

Vancouver:

Zhu Y. Rolle von Cytochrom P450 (CYP) -abhängigen Eicosanoide bei der experimentellen akuten Nierenschädigung (AKI). [Internet] [Thesis]. Freie Universität Berlin; 2015. [cited 2021 Mar 05]. Available from: http://dx.doi.org/10.17169/refubium-6041.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Zhu Y. Rolle von Cytochrom P450 (CYP) -abhängigen Eicosanoide bei der experimentellen akuten Nierenschädigung (AKI). [Thesis]. Freie Universität Berlin; 2015. Available from: http://dx.doi.org/10.17169/refubium-6041

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

6. Takaori, Koji. Severity and Frequency of Proximal Tubule Injury Determines Renal Prognosis .

Degree: 2018, Kyoto University

URL: http://hdl.handle.net/2433/232126

Subjects/Keywords: acute kidney injury (AKI); chronic kidney disease (CKD); proximal tubule injury; renal fibrosis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Takaori, K. (2018). Severity and Frequency of Proximal Tubule Injury Determines Renal Prognosis . (Thesis). Kyoto University. Retrieved from http://hdl.handle.net/2433/232126

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Takaori, Koji. “Severity and Frequency of Proximal Tubule Injury Determines Renal Prognosis .” 2018. Thesis, Kyoto University. Accessed March 05, 2021. http://hdl.handle.net/2433/232126.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Takaori, Koji. “Severity and Frequency of Proximal Tubule Injury Determines Renal Prognosis .” 2018. Web. 05 Mar 2021.

Vancouver:

Takaori K. Severity and Frequency of Proximal Tubule Injury Determines Renal Prognosis . [Internet] [Thesis]. Kyoto University; 2018. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/2433/232126.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Takaori K. Severity and Frequency of Proximal Tubule Injury Determines Renal Prognosis . [Thesis]. Kyoto University; 2018. Available from: http://hdl.handle.net/2433/232126

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Manitoba

7. Choi, Nora. Study of iron pathophysiology for early diagnosis of acute kidney injury secondary to ischemia reperfusion injury following cardiopulmonary bypass.

Degree: Immunology, 2017, University of Manitoba

URL: http://hdl.handle.net/1993/32763

► Currently, there are no successful therapies proven to ameliorate acute kidney injury (AKI). AKI secondary to ischemia reperfusion injury (IRI) leads to increased morbidity and… (more)

Subjects/Keywords: Acute kidney injury

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Choi, N. (2017). Study of iron pathophysiology for early diagnosis of acute kidney injury secondary to ischemia reperfusion injury following cardiopulmonary bypass. (Masters Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/32763

Chicago Manual of Style (16^th Edition):

Choi, Nora. “Study of iron pathophysiology for early diagnosis of acute kidney injury secondary to ischemia reperfusion injury following cardiopulmonary bypass.” 2017. Masters Thesis, University of Manitoba. Accessed March 05, 2021. http://hdl.handle.net/1993/32763.

MLA Handbook (7^th Edition):

Choi, Nora. “Study of iron pathophysiology for early diagnosis of acute kidney injury secondary to ischemia reperfusion injury following cardiopulmonary bypass.” 2017. Web. 05 Mar 2021.

Vancouver:

Choi N. Study of iron pathophysiology for early diagnosis of acute kidney injury secondary to ischemia reperfusion injury following cardiopulmonary bypass. [Internet] [Masters thesis]. University of Manitoba; 2017. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/1993/32763.

Council of Science Editors:

Choi N. Study of iron pathophysiology for early diagnosis of acute kidney injury secondary to ischemia reperfusion injury following cardiopulmonary bypass. [Masters Thesis]. University of Manitoba; 2017. Available from: http://hdl.handle.net/1993/32763

University of Western Ontario

8. Olvera-Posada, Daniel. Acute Kidney Injury Biomarkers: A Prospective Cohort Study In Urological Patients.

Degree: 2016, University of Western Ontario

URL: https://ir.lib.uwo.ca/etd/3763

► Several recent studies have assessed the use of biomarkers of Acute Kidney Injury (AKI), but the information among patients with stone disease and those with… (more)

Subjects/Keywords: Acute kidney injury (AKI); Hydronephrosis; Urinary biomarkers; Stone disease; Urinary tract obstruction; Ureteropelvic junction obstruction (UPJO); KIM-1; Total NGAL; Monomeric NGAL; Nephrology; Reproductive and Urinary Physiology; Urology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Olvera-Posada, D. (2016). Acute Kidney Injury Biomarkers: A Prospective Cohort Study In Urological Patients. (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/3763

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Olvera-Posada, Daniel. “Acute Kidney Injury Biomarkers: A Prospective Cohort Study In Urological Patients.” 2016. Thesis, University of Western Ontario. Accessed March 05, 2021. https://ir.lib.uwo.ca/etd/3763.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Olvera-Posada, Daniel. “Acute Kidney Injury Biomarkers: A Prospective Cohort Study In Urological Patients.” 2016. Web. 05 Mar 2021.

Vancouver:

Olvera-Posada D. Acute Kidney Injury Biomarkers: A Prospective Cohort Study In Urological Patients. [Internet] [Thesis]. University of Western Ontario; 2016. [cited 2021 Mar 05]. Available from: https://ir.lib.uwo.ca/etd/3763.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Olvera-Posada D. Acute Kidney Injury Biomarkers: A Prospective Cohort Study In Urological Patients. [Thesis]. University of Western Ontario; 2016. Available from: https://ir.lib.uwo.ca/etd/3763

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Otago

9. Nejat, Maryam. Biomarkers in early diagnosis of acute kidney injury .

Degree: 2011, University of Otago

URL: http://hdl.handle.net/10523/1915

► Acute Kidney injury (AKI) is common and frequently fatal. Delay in plasma creatinine based diagnosis of AKI has compromised clinical trials of experimentally promising therapies… (more)

▼ Acute Kidney injury (AKI) is common and frequently fatal. Delay in plasma creatinine based diagnosis of AKI has compromised clinical trials of experimentally promising therapies of kidney injury. Therefore, a number of potential early urinary and plasma biomarkers of renal cell injury have been evaluated in several clinical and experimental studies. However, many uncertainties remain in the diagnostic and predictive capability of these biomarkers in various forms of AKI, especially in heterogeneous population. The overall aim in this project was to analyse the diagnostic and predictive performance of some novel AKI biomarkers in a heterogeneous high-risk population. This project focused on the performance of plasma and urinary cystatin C (CysC) as markers of kidney function and injury respectively and both as predictors of mortality. This involved separate analysis of plasma and urinary CysC clinical data, and an experimental study investigating the performance of urinary CysC in the presence of albuminuria. Finally, the ability of fractional urinary biomarkers (fractional excretion of sodium (FENa) and urea (FEurea) to distinguish between so-called pre-renal AKI and established AKI was assessed. Clinical data came from the EARLYARF study, which was initiated by Professor Zoltan Endre prior to commencement of my PhD project. I participated in data collection and data entry for the large part of this study and I was provided access to the database to address the objectives of my thesis. The hypotheses were explored by analysing data arising from this study. The experimental study of the effect of proteinuria and albuminuria on urinary CysC arose from the observation of cystatinuria in children with proteinuria. This was explored in an animal model of transient albuminuria, which I developed. Plasma CysC has been proposed as an alternative to plasma creatinine as a measure of renal function. In Chapter 3, relative changes of plasma CysC and plasma creatinine were compared in critically ill patients. I was able to demonstrate that plasma CysC generally increased prior to plasma creatinine. Plasma CysC and creatinine were similarly moderately predictive of death or the need for dialysis. Plasma CysC was a more effective and earlier surrogate marker of decreased renal function than plasma creatinine in a general intensive care unit population. In Chapter 4, the utility of urinary CysC as a diagnostic marker of AKI, and predictor of mortality in critically ill patients was evaluated. Urinary CysC was diagnostic of and predictive of death. Unexpectedly, it was also found to be diagnostic of sepsis. Concentrations of urinary CysC were significantly higher in the presence of sepsis (p<0.0001) or AKI (p<0.0001). There was no interaction between sepsis and AKI on the urinary CysC concentrations (p=0.53). Urinary CysC was independently associated with AKI, sepsis, and death within 30 days. Low molecular weight (LMW) proteins, including albumin and novel urinary biomarkers of AKI such as CysC and neutrophil… Advisors/Committee Members: Endre, Zoltan Huba (advisor).

Subjects/Keywords: Acute kidney injury; Biomarkers

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Nejat, M. (2011). Biomarkers in early diagnosis of acute kidney injury . (Doctoral Dissertation). University of Otago. Retrieved from http://hdl.handle.net/10523/1915

Chicago Manual of Style (16^th Edition):

Nejat, Maryam. “Biomarkers in early diagnosis of acute kidney injury .” 2011. Doctoral Dissertation, University of Otago. Accessed March 05, 2021. http://hdl.handle.net/10523/1915.

MLA Handbook (7^th Edition):

Nejat, Maryam. “Biomarkers in early diagnosis of acute kidney injury .” 2011. Web. 05 Mar 2021.

Vancouver:

Nejat M. Biomarkers in early diagnosis of acute kidney injury . [Internet] [Doctoral dissertation]. University of Otago; 2011. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/10523/1915.

Council of Science Editors:

Nejat M. Biomarkers in early diagnosis of acute kidney injury . [Doctoral Dissertation]. University of Otago; 2011. Available from: http://hdl.handle.net/10523/1915

University of Toronto

10. Harel, Ziv. Association Between Early Follow-up with a Nephrologist and Death in Survivors of Acute Kidney Injury.

Degree: 2012, University of Toronto

URL: http://hdl.handle.net/1807/32466

►

Background: Survivors of severe acute kidney injury remain at high risk of death well-after apparent recovery from the initial event. Methods: We conducted a cohort… (more)

Subjects/Keywords: acute kidney injury; 0766

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APA (6^th Edition):

Harel, Z. (2012). Association Between Early Follow-up with a Nephrologist and Death in Survivors of Acute Kidney Injury. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/32466

Chicago Manual of Style (16^th Edition):

Harel, Ziv. “Association Between Early Follow-up with a Nephrologist and Death in Survivors of Acute Kidney Injury.” 2012. Masters Thesis, University of Toronto. Accessed March 05, 2021. http://hdl.handle.net/1807/32466.

MLA Handbook (7^th Edition):

Harel, Ziv. “Association Between Early Follow-up with a Nephrologist and Death in Survivors of Acute Kidney Injury.” 2012. Web. 05 Mar 2021.

Vancouver:

Harel Z. Association Between Early Follow-up with a Nephrologist and Death in Survivors of Acute Kidney Injury. [Internet] [Masters thesis]. University of Toronto; 2012. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/1807/32466.

Council of Science Editors:

Harel Z. Association Between Early Follow-up with a Nephrologist and Death in Survivors of Acute Kidney Injury. [Masters Thesis]. University of Toronto; 2012. Available from: http://hdl.handle.net/1807/32466

University of Minnesota

11. Leither, Maxwell. Outpatient Acute Kidney Injury Increases Risk of Mortality and Chronic Kidney Disease.

Degree: MS, Clinical Research, 2017, University of Minnesota

URL: http://hdl.handle.net/11299/198958

► Introduction: Limited data exist regarding outcomes of patients with outpatient acute kidney injury (AKI). To determine whether outpatient AKI is associated with increased mortality and… (more)

Subjects/Keywords: acute kidney injury; chronic kidney disease; nephrology

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APA (6^th Edition):

Leither, M. (2017). Outpatient Acute Kidney Injury Increases Risk of Mortality and Chronic Kidney Disease. (Masters Thesis). University of Minnesota. Retrieved from http://hdl.handle.net/11299/198958

Chicago Manual of Style (16^th Edition):

Leither, Maxwell. “Outpatient Acute Kidney Injury Increases Risk of Mortality and Chronic Kidney Disease.” 2017. Masters Thesis, University of Minnesota. Accessed March 05, 2021. http://hdl.handle.net/11299/198958.

MLA Handbook (7^th Edition):

Leither, Maxwell. “Outpatient Acute Kidney Injury Increases Risk of Mortality and Chronic Kidney Disease.” 2017. Web. 05 Mar 2021.

Vancouver:

Leither M. Outpatient Acute Kidney Injury Increases Risk of Mortality and Chronic Kidney Disease. [Internet] [Masters thesis]. University of Minnesota; 2017. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/11299/198958.

Council of Science Editors:

Leither M. Outpatient Acute Kidney Injury Increases Risk of Mortality and Chronic Kidney Disease. [Masters Thesis]. University of Minnesota; 2017. Available from: http://hdl.handle.net/11299/198958

University of Toronto

12. Chaturvedi, Swasti. SLIT2 Prevents Renal Ischemia Reperfusion Injury in Mice.

Degree: 2012, University of Toronto

URL: http://hdl.handle.net/1807/42902

►

The Slit family of secreted proteins act as axonal repellents during embryogenesis. Slit2 via its receptor, Roundabout-1, also inhibits chemotaxis of multiple leukocyte subsets. Using… (more)

Subjects/Keywords: acute kidney injury; ischaemia-reperfusion injury; 0379

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APA (6^th Edition):

Chaturvedi, S. (2012). SLIT2 Prevents Renal Ischemia Reperfusion Injury in Mice. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/42902

Chicago Manual of Style (16^th Edition):

Chaturvedi, Swasti. “SLIT2 Prevents Renal Ischemia Reperfusion Injury in Mice.” 2012. Masters Thesis, University of Toronto. Accessed March 05, 2021. http://hdl.handle.net/1807/42902.

MLA Handbook (7^th Edition):

Chaturvedi, Swasti. “SLIT2 Prevents Renal Ischemia Reperfusion Injury in Mice.” 2012. Web. 05 Mar 2021.

Vancouver:

Chaturvedi S. SLIT2 Prevents Renal Ischemia Reperfusion Injury in Mice. [Internet] [Masters thesis]. University of Toronto; 2012. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/1807/42902.

Council of Science Editors:

Chaturvedi S. SLIT2 Prevents Renal Ischemia Reperfusion Injury in Mice. [Masters Thesis]. University of Toronto; 2012. Available from: http://hdl.handle.net/1807/42902

University of Notre Dame

13. Kristen Koenig McCampbell. Nephron regeneration after acute kidney injury in the zebrafish</h1>.

Degree: Biological Sciences, 2013, University of Notre Dame

URL: https://curate.nd.edu/show/q811kh06s21

► Acute kidney injury (AKI) is a devastating and often lethal condition in which kidney nephron cells are destroyed by damage from ischemia or toxin… (more)

▼ Acute kidney injury (AKI) is a devastating and often lethal condition in which kidney nephron cells are destroyed by damage from ischemia or toxin exposure. Interestingly, there is evidence that suggests nephron epithelial cells can regenerate after some forms of damage, but there is a poor understanding of the cellular and molecular events that mediate nephron regeneration. The zebrafish is an attractive and viable system to study the molecular pathways responsible for nephron regeneration, as its nephrons are simple, yet they maintain the biological complexity inherent to that of higher organisms including mammals. Previous studies have demonstrated that gentamicin-based chemical injury in zebrafish mimics human AKI, but detailed analysis of the cellular events associated with damage was not reported. We generated a novel toolkit of cellular and molecular protocols to perform this analysis in the zebrafish. We explored the feasibility of AKI studies in the zebrafish embryo, and identified basic aspects of the injury process. Next, we extensively characterized the cellular changes resulting from gentamicin injury in the adult zebrafish using our platform of histology and immunohistochemistry techniques. This work has established the timing of renal cell death after injury, identified proliferative compartments within the kidney, and led to the assessment of gene expression changes associated with the regenerative response of proliferating cells. Taken together, this dissertation project has provided a greater understanding of the full cycle of regenerative events. Insights from this work can be applied in future studies toward the design of chemical genetics screens in the adult and/or embryonic zebrafish to identify renal regeneration pathways and provide novel insights into the signals that orchestrate kidney epithelial regeneration. Advisors/Committee Members: Dr. John G. Duman, Committee Member, Dr. Zachary T. Schafer, Committee Member, Dr. Rebecca A. Wingert, Committee Chair.

Subjects/Keywords: tubular injury; regeneration; acute kidney injury; kidney; repair; zebrafish

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APA (6^th Edition):

McCampbell, K. K. (2013). Nephron regeneration after acute kidney injury in the zebrafish</h1>. (Thesis). University of Notre Dame. Retrieved from https://curate.nd.edu/show/q811kh06s21

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

McCampbell, Kristen Koenig. “Nephron regeneration after acute kidney injury in the zebrafish</h1>.” 2013. Thesis, University of Notre Dame. Accessed March 05, 2021. https://curate.nd.edu/show/q811kh06s21.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

McCampbell, Kristen Koenig. “Nephron regeneration after acute kidney injury in the zebrafish</h1>.” 2013. Web. 05 Mar 2021.

Vancouver:

McCampbell KK. Nephron regeneration after acute kidney injury in the zebrafish</h1>. [Internet] [Thesis]. University of Notre Dame; 2013. [cited 2021 Mar 05]. Available from: https://curate.nd.edu/show/q811kh06s21.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

McCampbell KK. Nephron regeneration after acute kidney injury in the zebrafish</h1>. [Thesis]. University of Notre Dame; 2013. Available from: https://curate.nd.edu/show/q811kh06s21

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Melbourne

14. Roberts, Veena. Therapeutic potential of the adenosinergic pathway in acute and chronic kidney disease following ischaemia reperfusion injury.

Degree: 2016, University of Melbourne

URL: http://hdl.handle.net/11343/108552

► The incidence of chronic kidney disease (CKD) is rising and the consequences of CKD include premature mortality and progression to end stage kidney disease. Renal… (more)

▼ The incidence of chronic kidney disease (CKD) is rising and the consequences of CKD include premature mortality and progression to end stage kidney disease. Renal ischaemia reperfusion injury (IRI) occurring in clinical settings leads to acute kidney injury (AKI) that predisposes to the development of CKD. The hallmark lesion in CKD is renal fibrosis and clinically there is no direct anti-fibrotic therapy available to halt or reverse the development of renal fibrosis. The adenosinergic pathway is activated during renal IRI and the enzyme CD39 is involved in the generation of adenosine, which has been demonstrated to be protective in the acute phase of IRI. This thesis explores the potential of CD39 (either overexpression of a CD39 transgene or administration of soluble apyrase) and the adenosine A2B receptor (A2BR) as therapeutic targets in the reduction of renal fibrosis that develops after the acute phase of IRI. Using mouse models of renal IRI, it was demonstrated that a transient increase in CD39 activity before IRI, by administration of the enzyme apyrase, effectively reduced AKI and renal fibrosis. However, continuously elevated CD39 activity, achieved by overexpression of the human CD39 transgene (CD39Tg), protected against AKI but led to increased renal adenosine content and increased renal fibrosis. Renal fibrosis following IRI was also shown to be associated with increased A2BR mRNA expression in the kidney, and the role of the A2BR in renal fibrosis was examined by administration of a specific A2BR inhibitor. Inhibition of the A2BR following IRI significantly down-regulated a number of signalling molecules that contribute to fibrosis, although no change in fibrosis was demonstrable. While increased adenosine and A2BR activity protect from acute IRI, these studies show that a sustained increase in adenosine levels and increased A2BR expression after IRI promote renal fibrosis. This suggests a dual role for adenosine and the A2BR in renal injury following IRI, which has not previously been recognised. Finally, in a model of unilateral ureteric obstruction (UUO), CD39Tg mice developed a similar extent of fibrosis to that of WT littermates, in contrast to the increased renal fibrosis seen in CD39Tg mice after IRI. These findings indicate that different mechanisms of injury affect different pathways in the development of renal fibrosis. In conclusion, the studies described in this thesis demonstrate that soluble apyrase and A2BR inhibition are potential therapeutic tools to reduce the development of renal fibrosis following IRI. This thesis also highlights the need to identify and understand the multiple pathways involved in the development of renal fibrosis and the possibility that combination therapies will be more effective than single agents in the treatment and prevention of CKD following IRI.

Subjects/Keywords: adenosine; ischaemia reperfusion injury; acute kidney injury; chronic kidney disease

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Roberts, V. (2016). Therapeutic potential of the adenosinergic pathway in acute and chronic kidney disease following ischaemia reperfusion injury. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/108552

Chicago Manual of Style (16^th Edition):

Roberts, Veena. “Therapeutic potential of the adenosinergic pathway in acute and chronic kidney disease following ischaemia reperfusion injury.” 2016. Doctoral Dissertation, University of Melbourne. Accessed March 05, 2021. http://hdl.handle.net/11343/108552.

MLA Handbook (7^th Edition):

Roberts, Veena. “Therapeutic potential of the adenosinergic pathway in acute and chronic kidney disease following ischaemia reperfusion injury.” 2016. Web. 05 Mar 2021.

Vancouver:

Roberts V. Therapeutic potential of the adenosinergic pathway in acute and chronic kidney disease following ischaemia reperfusion injury. [Internet] [Doctoral dissertation]. University of Melbourne; 2016. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/11343/108552.

Council of Science Editors:

Roberts V. Therapeutic potential of the adenosinergic pathway in acute and chronic kidney disease following ischaemia reperfusion injury. [Doctoral Dissertation]. University of Melbourne; 2016. Available from: http://hdl.handle.net/11343/108552

15. Karathanasis, Dimitrios. Οξεία νεφρική βλάβη μετά από καρδιοχειρουργική επέμβαση: διαγνωστική αξία βιοδεικτών.

Degree: 2019, University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας

URL: http://hdl.handle.net/10442/hedi/46038

►

Background: Cardiac Surgery Associated Acute Kidney Injury (CSA-AKI) is one of the most serious complications of heart surgery. The fact of the known time of… (more)

▼

Background: Cardiac Surgery Associated Acute Kidney Injury (CSA-AKI) is one of the most serious complications of heart surgery. The fact of the known time of an elective cardiac surgery makes it an ideal model for early diagnosis and prevention of CSA-AKI. The aim of the study is to investigate the effect of hydration both on the frequency of CSA-AKI and on the biomarkers Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Kidney Injury Molecule-1 (KIM-1) by focusing on sodium bicarbonate and sodium chloride solutions. Secondary aim is to examine the diagnostic value of biomarkers in the prediction of CSA-AKI by focusing on the predictive system of Age-Creatinine-Ejection Fraction (ACEF) score, the postoperative change in serum creatinine six hours after the induction of anesthesia (ΔSCr) as well as the newer molecules NGAL and KIM-1 with the pursuit of developing an ideal prevention tool. Material and Methods: From February 2012 to October 2014, all adult patients who underwent elective, on pump artery bypass grafting and/or valve repair with a predisposition to manifest CSA-AKI were enrolled. Patients were randomized to intravenous infusion of isotonic sodium chloride or sodium bicarbonate or none of them for 24 hours. Urinary NGAL and KIM-1 were measured before the induction of anesthesia and 18 hours post-surgery. CSA-AKI was defined on the basis of the current guidelines of Kidney Disease Improving Global Outcomes (KDIGO). All statistical analyses were conducted using SPSS 24.Results: From a total of 112, finally enrolled in the study 86 patients. CSA-AKI appeared in 14 (16,3%) patients. No statistically significant correlation was observed between isotonic sodium chloride or sodium bicarbonate solution and the manifestation of CSA-AKI. Also, there was not observed any statistically significant effect of hydration with isotonic sodium chloride or sodium bicarbonate solution on biomarkers NGAL and KIM-1. ΔSCr, ACEF score, NGAL and KIM-1 as CSA-AKI biomarkers showed AUC of 0.537, 0.692, 0.575 and 0.507 respectively. NGAL and KIM-1 combination showed AUC of 0.507 while ΔSCr combinations with NGAL and KIM-1 had similarly low scores. The combinations with ACEF score showed high AUCs and especially the combination of post-operative NGAL with ACEF score had AUC of 0.768. The combination of post-operative NGAL and KIM-1 with ACEF score showed AUC of 0.788. Conclusions: Hydration with isotonic sodium bicarbonate solution or normal saline does not deter the manifestation of CSA-AKI nor does it affect the biomarkers NGAL and KIM-1. The combination of NGAL 18 hours postoperatively with ACEF score is a reliable prognostic biomarker of CSA-AKI.

Εισαγωγή: Η σχετιζόμενη με καρδιοχειρουργική επέμβαση οξεία νεφρική βλάβη (ΣΚΕ-ONB) αποτελεί μια από τις σημαντικότερες επιπλοκές των καρδιακών επεμβάσεων. Το δεδομένο του γνωστού χρόνου υλοποίησης ενός προγραμματισμένου χειρουργείου καρδιάς, το καθιστά ιδανικό μοντέλο μελέτης των μηχανισμών έγκαιρης διάγνωσης και πρόληψης της ΣΚΕ-ONB. Σκοπός της μελέτης είναι να διερευνήσει την…

Subjects/Keywords: Οξεία νεφρική βλάβη; Acute kidney injury

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APA (6^th Edition):

Karathanasis, D. (2019). Οξεία νεφρική βλάβη μετά από καρδιοχειρουργική επέμβαση: διαγνωστική αξία βιοδεικτών. (Thesis). University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας. Retrieved from http://hdl.handle.net/10442/hedi/46038

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Karathanasis, Dimitrios. “Οξεία νεφρική βλάβη μετά από καρδιοχειρουργική επέμβαση: διαγνωστική αξία βιοδεικτών.” 2019. Thesis, University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας. Accessed March 05, 2021. http://hdl.handle.net/10442/hedi/46038.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Karathanasis, Dimitrios. “Οξεία νεφρική βλάβη μετά από καρδιοχειρουργική επέμβαση: διαγνωστική αξία βιοδεικτών.” 2019. Web. 05 Mar 2021.

Vancouver:

Karathanasis D. Οξεία νεφρική βλάβη μετά από καρδιοχειρουργική επέμβαση: διαγνωστική αξία βιοδεικτών. [Internet] [Thesis]. University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας; 2019. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/10442/hedi/46038.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Karathanasis D. Οξεία νεφρική βλάβη μετά από καρδιοχειρουργική επέμβαση: διαγνωστική αξία βιοδεικτών. [Thesis]. University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας; 2019. Available from: http://hdl.handle.net/10442/hedi/46038

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Cape Town

16. Mzingeli, Luvuyo. Study of epidemiology, management and outcome of acute kidney injury post noncardiac surgery over 12 months at Groote Schuur Hospital, Cape Town.

Degree: Image, Medicine, 2015, University of Cape Town

URL: http://hdl.handle.net/11427/17425

► INTRODUCTION : Acute kidney injury (AKI) is a disorder that is defined by rising serum creatinine and reduced urine output. It occurs in approximately 1-7%… (more)

▼ INTRODUCTION : Acute kidney injury (AKI) is a disorder that is defined by rising serum creatinine and reduced urine output. It occurs in approximately 1-7% of hospitalized patients and is a major predictor of morbidity and mortality. It increases the costs and duration of hospital stay. AKI has been extensively studied post cardiac surgery, but there has been little attention on AKI occurring after non cardiac surgery . There have been few studies on AKI from developing countries and a paucity of data of post non cardiac surgery AKI. OBJECTIVE : To identify which known risk factors for AKI are commonly encountered at Groote Schuur Hospital, to document 30 and 90 day mortality, length of hospital stay, recovery of renal function at 90 days and identify factors associated with outcome post non-cardiac surgery. DESIGN: Prospective observational study. SETTING: Surgical Wards and ICU. PARTICIPANTS: Patients with AKI post non-cardiac surgery admitted between July 2012 and July 2013, who were 18 years and above without underlying stage 5 chronic kidney disease. OUTCOME MEASURES: Mortality, identification of risk factors, length of hospital stay and recovery of renal function. RESULTS: Of 367 patients referred to renal unit with AKI, 60 patients met inclusion criteria. Patients had an average age of 52.8 years (standard deviation 16.6) and 70% (42/60) were male. 61.7% (37 /60) were Coloured, 20% (12/60) were White and 18.3% (11/60) were Black. These patients were exposed to the following risk factors: 80%(48/60) had emergency surgery, 66. 7%(40/60) had sepsis, 65%(39/60) had perioperative contrast exposure, 53.3%(32/60) had hypotension that required inotropic support in 50%(30/60). Mortality was 33.3% (20/60) at 30 days and 45% (27/60) at 90 days. Of the 33 patients who did not die, 81.8% (27 /33) recovered their renal function to normal baseline creatinine at 90 days. Of the 6 patients, whose renal function did not return to baseline, none required long term dialysis. Perioperative contrast exposure was associated with a longer median length of hospital stay compared to patients not exposed to contrast (21 vs 16 days respectively, p<0.05). Sepsis and age > 60 years was associated with poor recovery of renal function (p=0.005, p=0.01 respectively). No risk factor was identified to be associated with mortality. CONCLUSION: Risk factors for post non cardiac surgery AKI commonly encountered at Groote Schuur Hospital were emergency surgery, sepsis, hypotension, perioperative use of inotropes and perioperative contrast exposure. The latter was identified as a modifiable risk factor which significantly prolonged hospital stay. Sepsis and age > 60 years were associated with poorer recovery of renal function. Advisors/Committee Members: Rayner, Brian L (advisor).

Subjects/Keywords: acute kidney injury; post noncardiac surgery

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APA (6^th Edition):

Mzingeli, L. (2015). Study of epidemiology, management and outcome of acute kidney injury post noncardiac surgery over 12 months at Groote Schuur Hospital, Cape Town. (Thesis). University of Cape Town. Retrieved from http://hdl.handle.net/11427/17425

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mzingeli, Luvuyo. “Study of epidemiology, management and outcome of acute kidney injury post noncardiac surgery over 12 months at Groote Schuur Hospital, Cape Town.” 2015. Thesis, University of Cape Town. Accessed March 05, 2021. http://hdl.handle.net/11427/17425.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mzingeli, Luvuyo. “Study of epidemiology, management and outcome of acute kidney injury post noncardiac surgery over 12 months at Groote Schuur Hospital, Cape Town.” 2015. Web. 05 Mar 2021.

Vancouver:

Mzingeli L. Study of epidemiology, management and outcome of acute kidney injury post noncardiac surgery over 12 months at Groote Schuur Hospital, Cape Town. [Internet] [Thesis]. University of Cape Town; 2015. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/11427/17425.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mzingeli L. Study of epidemiology, management and outcome of acute kidney injury post noncardiac surgery over 12 months at Groote Schuur Hospital, Cape Town. [Thesis]. University of Cape Town; 2015. Available from: http://hdl.handle.net/11427/17425

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of New South Wales

17. Pianta, Timothy. Biomarkers of acute kidney injury and delayed graft function. Structure, function, and the effect of treatment.

Degree: Clinical School - Prince of Wales Hospital, 2015, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/56421 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:40689/SOURCE02?view=true

► Increases in serum creatinine (sCr) and oliguria are the current functional criteria for recognising acute kidney injury (AKI) including AKI causing delayed graft function (DGF)… (more)

▼ Increases in serum creatinine (sCr) and oliguria are the current functional criteria for recognising acute kidney injury (AKI) including AKI causing delayed graft function (DGF) and slow graft function (SGF) following kidney transplantation. However, there are limitations to GFR reduction as a marker of AKI or its successful treatment. Moreover, increases in sCr or oliguria have limitations as surrogates of GFR. Alternatives for evaluation of AKI and DGF include other functional biomarkers and urinary biomarkers of kidney damage.We developed a time-dependent biomarker profile of moderate-to-severe cisplatin-induced AKI in rats, and evaluated histological injury, functional biomarkers, and kidney-damage biomarkers. Several potential interventions to ameliorate cisplatin-induced AKI were then assessed. Subsequently, kidney damage biomarkers were monitored during the functional amelioration of alpha-lipoic acid (A-LA) for treatment of cisplatin-induced-AKI, with the general aim of evaluating whether damage biomarkers could improve monitoring of intervention in AKI. The clinical use of novel functional and damage biomarkers in the diagnosis of cisplatin-induced AKI was also evaluated in an observational study. Finally, observational studies were conducted to evaluate functional biomarkers including kinetic eGFR, and kidney damage biomarkers for diagnosis of DGF or SGF. A-LA treatment ameliorated cisplatin-induced AKI in rats with protection demonstrated by reductions in structural damage, markers of loss of function, and in biomarkers of tubular damage. In the first clinical study, plasma cystatin C increased independently of other functional or damage AKI biomarkers after cisplatin-based chemotherapy, suggesting limitations to cystatin C use in this context. In a second clinical study, VEGF-A, urinary clusterin and the cell cycle arrest biomarkers TIMP-2 and IGFBP7 predicted with DGF within 4 hours of transplantation. Despite the usual limitations of sCr, early and frequent assessment of rate of change of sCr also predicted DGF: the creatinine reduction ratio predicted DGF within 12 hours, while estimates of kinetic GFR were predictive within 4 hours of renal transplantation.Despite a clear need for novel AKI biomarkers, their use and interpretation remains context-specific. These novel AKI biomarkers require robust pre-clinical data, evaluation in specific contexts, and comparison with currently available parameters before clinical use. Advisors/Committee Members: Endre, Zoltan, Clinical School - Prince of Wales Hospital, Faculty of Medicine, UNSW, Buckley, Nicholas, Clinical School - Prince of Wales Hospital, Faculty of Medicine, UNSW, Peake, Philip (deceased), Clinical School - Prince of Wales Hospital, Faculty of Medicine, UNSW.

Subjects/Keywords: Biomarkers; Acute Kidney Injury; Delayed Graft Function

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APA (6^th Edition):

Pianta, T. (2015). Biomarkers of acute kidney injury and delayed graft function. Structure, function, and the effect of treatment. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/56421 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:40689/SOURCE02?view=true

Chicago Manual of Style (16^th Edition):

Pianta, Timothy. “Biomarkers of acute kidney injury and delayed graft function. Structure, function, and the effect of treatment.” 2015. Doctoral Dissertation, University of New South Wales. Accessed March 05, 2021. http://handle.unsw.edu.au/1959.4/56421 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:40689/SOURCE02?view=true.

MLA Handbook (7^th Edition):

Pianta, Timothy. “Biomarkers of acute kidney injury and delayed graft function. Structure, function, and the effect of treatment.” 2015. Web. 05 Mar 2021.

Vancouver:

Pianta T. Biomarkers of acute kidney injury and delayed graft function. Structure, function, and the effect of treatment. [Internet] [Doctoral dissertation]. University of New South Wales; 2015. [cited 2021 Mar 05]. Available from: http://handle.unsw.edu.au/1959.4/56421 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:40689/SOURCE02?view=true.

Council of Science Editors:

Pianta T. Biomarkers of acute kidney injury and delayed graft function. Structure, function, and the effect of treatment. [Doctoral Dissertation]. University of New South Wales; 2015. Available from: http://handle.unsw.edu.au/1959.4/56421 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:40689/SOURCE02?view=true

University of New South Wales

18. Abdul Cader, Mohamed Fahim. Human nephrotoxicity assessment using novel renal biomarkers following herbicide self-poisoning in less developed countries.

Degree: Clinical School - Prince of Wales Hospital, 2015, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/54941 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:36223/SOURCE02?view=true

► Acute kidney injury (AKI) following self-poisoning with herbicides is common and an important predictor of mortality. Early diagnosis may reduce mortality if successful treatments are… (more)

▼ Acute kidney injury (AKI) following self-poisoning with herbicides is common and an important predictor of mortality. Early diagnosis may reduce mortality if successful treatments are developed. AKI is diagnosed by changes in serum creatinine (sCr), a surrogate of glomerular filtration rate (GFR). This delays diagnosis and underestimates extent of injury, so use of sCr to diagnose nephrotoxicity is suboptimal. We prospectively studied Sri Lankan subjects admitted to hospitals following deliberate drug/chemical ingestion and after snake envenomation. This thesis focuses on two herbicides, paraquat and glyphosate. Firstly, we hypothesised that the abrupt increase in sCr following paraquat poisoning was so rapid and was unlikely to be due solely to nephrotoxicity. We assessed this by comparing kinetics of sCr and serum cystatin C, and influences of non-renal factors. The increase in creatinine greatly exceeded that predicted or even possible with maximal decreases in GFR. We speculated this represents increased production of creatine and creatinine to meet energy demands following paraquat-induced oxidative stress. Creatinine was not a good marker of GFR and paraquat nephrotoxicity should be evaluated using more specific renal biomarkers.The utility of 10 structural injury biomarkers was then evaluated. Three (urinary cystatin C, NGAL and clusterin) of 10 showed a modest performance in detecting AKI. Most patients with AKI died due to multi-organ failure within 2 days and sCr predicted mortality independently of GFR. Therefore, any additional clinical utility of injury biomarkers to sCr was limited in paraquat poisoning.We assessed the influence of proteinuria on biomarker excretion. Albuminuria was associated with increased excretion of most biomarkers and biomarker cutoffs for prediction of death were higher. Diagnostic cutoffs for outcome prediction and stratification must be modified if albuminuria is due to comorbid conditions.Finally, the role of biomarkers in detecting nephrotoxicity and their added value to sCr was evaluated in 90 patients following glyphosate-surfactant herbicide (GPSH) poisoning. GPSH-induced nephrotoxicity was common but generally mild and reversible. It can be diagnosed within 8-16 hours by cytochrome C (uCytoC). The early increases in uCytoC and interleukin-18 support a primary mechanism of GPSH-induced nephrotoxicity involving mitochondrial toxicity and apoptosis and use of these biomarkers may identify mechanism-specific targets for treatments. Advisors/Committee Members: Buckley, Nicholas Allan, Clinical School - Prince of Wales Hospital, Faculty of Medicine, UNSW, Endre, Zoltan Huba, Clinical School - Prince of Wales Hospital, Faculty of Medicine, UNSW.

Subjects/Keywords: Herbicide Poisoning; Acute Kidney Injury; Biomarkers

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APA (6^th Edition):

Abdul Cader, M. F. (2015). Human nephrotoxicity assessment using novel renal biomarkers following herbicide self-poisoning in less developed countries. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/54941 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:36223/SOURCE02?view=true

Chicago Manual of Style (16^th Edition):

Abdul Cader, Mohamed Fahim. “Human nephrotoxicity assessment using novel renal biomarkers following herbicide self-poisoning in less developed countries.” 2015. Doctoral Dissertation, University of New South Wales. Accessed March 05, 2021. http://handle.unsw.edu.au/1959.4/54941 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:36223/SOURCE02?view=true.

MLA Handbook (7^th Edition):

Abdul Cader, Mohamed Fahim. “Human nephrotoxicity assessment using novel renal biomarkers following herbicide self-poisoning in less developed countries.” 2015. Web. 05 Mar 2021.

Vancouver:

Abdul Cader MF. Human nephrotoxicity assessment using novel renal biomarkers following herbicide self-poisoning in less developed countries. [Internet] [Doctoral dissertation]. University of New South Wales; 2015. [cited 2021 Mar 05]. Available from: http://handle.unsw.edu.au/1959.4/54941 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:36223/SOURCE02?view=true.

Council of Science Editors:

Abdul Cader MF. Human nephrotoxicity assessment using novel renal biomarkers following herbicide self-poisoning in less developed countries. [Doctoral Dissertation]. University of New South Wales; 2015. Available from: http://handle.unsw.edu.au/1959.4/54941 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:36223/SOURCE02?view=true

University of Cincinnati

19. Hanson, Holly R, M.D. Describing Pediatric Acute Kidney Injury in the Emergency Department.

Degree: MS, Medicine: Clinical and Translational Research, 2016, University of Cincinnati

URL: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1459528673

► Background: Acute kidney injury (AKI), caused by decreased renal perfusion or a direct kidney insult, results in increased morbidity and mortality independent of underlying disease… (more)

▼ Background: Acute kidney injury (AKI), caused by decreased renal perfusion or a direct kidney insult, results in increased morbidity and mortality independent of underlying disease pathology in children. Early recognition, particularly in the Emergency Department (ED), is paramount to mitigate further injury induced by nephrotoxic treatments. Diagnosis of AKI by current definition utilizing changes in serum creatinine (SCr) is challenging in the pediatric setting and can lead to delayed recognition. No studies have defined the scope of this problem from the pediatric ED.Objectives: To (1) define those children who develop AKI within 48 hours of admission from the ED and (2) ascertain patient-related factors identifiable in the ED that is associated with AKI. Study Design: This is a retrospective, observational study of children birth to 19 years of age who were admitted to a pediatric hospital from the ED between 01/2010 and 12/2013 and had a SCr drawn within the first 48 hours. Exclusion criteria included being anephric, a history of chronic kidney disease stage IV or V, or a recent admission/surgery within 72 hours of presentation. AKI was defined as a serum creatinine = 1.5 times baseline or, where baseline not present it was imputed using an estimated creatinine clearance of 120 ml/min/1.73 m2. Demographics, medical history, laboratory values, medications, procedures, and disposition were extracted. Frequencies were used to characterize the population. Differences between groups were determined by t-tests or chi-square analysis. A list of patient-related factors associated with AKI in the ED was formulated a priori based on current literature and included demographics, past medical history, past surgical history, ED procedures, ED medications, and disposition. Bivariable and multivariable logistic regression was performed to determine factors associated with development of AKI. Results: The study cohort comprised 13,827 subjects, of which 1,436 (10.4%) had AKI (34.8% were SCr = 2.0 times above baseline) and 1083 (75%) were identifiable in the ED. Of those kids with AKI, 2.7% required dialysis, 0.6% required intubation in the ED, 0.4% had inotropy started in the ED, 17.2% required central venous access, and 2.0% died during the hospital admission (all significantly more than children without AKI). Nearly 20% with AKI received a nephrotoxic medication in the ED. All factors identified a priori were entered into the bivariable model, had a p < 0.25, and then were added to the multivariable model. Young age, history of AKI, history of solid organ transplant, receiving intravenous fluids in the ED, central venous access in the ED, and admission to the intensive care unit (ICU) were all factors independently associated with AKI.Conclusions: One child per day, admitted at a large tertiary hospital, had AKI while in the ED. 25% were not identifiable by current methods. Young age, history of solid organ transplant and AKI, need for central venous access, intravenous fluid in the ED and ICU admission are all independently… Advisors/Committee Members: Haynes, Erin Nicole (Committee Chair).

Subjects/Keywords: Surgery; Pediatrics; Acute Kidney Injury; Emergency Department

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hanson, Holly R, M. D. (2016). Describing Pediatric Acute Kidney Injury in the Emergency Department. (Masters Thesis). University of Cincinnati. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=ucin1459528673

Chicago Manual of Style (16^th Edition):

Hanson, Holly R, M D. “Describing Pediatric Acute Kidney Injury in the Emergency Department.” 2016. Masters Thesis, University of Cincinnati. Accessed March 05, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1459528673.

MLA Handbook (7^th Edition):

Hanson, Holly R, M D. “Describing Pediatric Acute Kidney Injury in the Emergency Department.” 2016. Web. 05 Mar 2021.

Vancouver:

Hanson, Holly R MD. Describing Pediatric Acute Kidney Injury in the Emergency Department. [Internet] [Masters thesis]. University of Cincinnati; 2016. [cited 2021 Mar 05]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1459528673.

Council of Science Editors:

Hanson, Holly R MD. Describing Pediatric Acute Kidney Injury in the Emergency Department. [Masters Thesis]. University of Cincinnati; 2016. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1459528673

Harvard University

20. Hayden, Robert Morse. FDG-PET/CT Imaging in Acute and Chronic Kidney Disease.

Degree: Doctor of Medicine, 2019, Harvard University

URL: http://nrs.harvard.edu/urn-3:HUL.InstRepos:41971527

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We evaluated the possibility of using FDG PET CT imaging in the kidneys of patients with acute and chronic kidney disease. This was a retrospective… (more)

Subjects/Keywords: PET; AKI; CKD; kidney; renal

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hayden, R. M. (2019). FDG-PET/CT Imaging in Acute and Chronic Kidney Disease. (Doctoral Dissertation). Harvard University. Retrieved from http://nrs.harvard.edu/urn-3:HUL.InstRepos:41971527

Chicago Manual of Style (16^th Edition):

Hayden, Robert Morse. “FDG-PET/CT Imaging in Acute and Chronic Kidney Disease.” 2019. Doctoral Dissertation, Harvard University. Accessed March 05, 2021. http://nrs.harvard.edu/urn-3:HUL.InstRepos:41971527.

MLA Handbook (7^th Edition):

Hayden, Robert Morse. “FDG-PET/CT Imaging in Acute and Chronic Kidney Disease.” 2019. Web. 05 Mar 2021.

Vancouver:

Hayden RM. FDG-PET/CT Imaging in Acute and Chronic Kidney Disease. [Internet] [Doctoral dissertation]. Harvard University; 2019. [cited 2021 Mar 05]. Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:41971527.

Council of Science Editors:

Hayden RM. FDG-PET/CT Imaging in Acute and Chronic Kidney Disease. [Doctoral Dissertation]. Harvard University; 2019. Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:41971527

21. Sato, Ko. Nephrotoxicity of cisplatin combination chemotherapy in thoracic malignancy patients with CKD risk factors. : 合併症を有する胸部悪性腫瘍患者に対するシスプラチン併用化学療法の腎障害のリスク解析.

Degree: 博士（医学）, 2017, Niigata University / 新潟大学

URL: http://hdl.handle.net/10191/47613

►

学位の種類: 博士（医学）. 報告番号: 甲第4268号. 学位記番号: 新大院博（医）甲第746号. 学位授与年月日: 平成29年3月23日

BMC Cancer. 2016; 16: 222

Background : Nephrotoxicity is the major side effect that limits the dose… (more)

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学位の種類: 博士（医学）. 報告番号: 甲第4268号. 学位記番号: 新大院博（医）甲第746号. 学位授与年月日: 平成29年3月23日

BMC Cancer. 2016; 16: 222

Background : Nephrotoxicity is the major side effect that limits the dose of cisplatin that can be safely administered, and it is a clinical problem in cancer patients who received cisplatin combination chemotherapy. Recent evidence has demonstrated that patients with chronic kidney disease (CKD) have an increased risk of developing acute kidney injury (AKI). The present study was conducted to evaluate the prevalence of CKD risk factors in patients who received cisplatin and to assess the correlation between CKD risk factors and cisplatin-induced AKI.Methods : We retrospectively analyzed 84 patients treated with cisplatin combination chemotherapy for thoracic malignancies. AKI was defined as a decrease in the estimated glomerular filtration rate (eGFR) > 25 % from base line, an increase in the serum creatinine (sCre) level of > 0.3 mg/dl or ≥ 1.5 times the baseline level.Results : Eighty of the 84 patients (95.2 %) had at least one risk factor for CKD. All enrolled patients received cisplatin with hydration, magnesium supplementation and mannitol. Cisplatin-induced AKI was observed in 18 patients (21.4 %). Univariate analysis revealed that cardiac disease and use of non-steroidal anti-inflammatory drugs (NSAIDs) were associated with cisplatin-induced nephrotoxicity (odds ratios [OR] 6 and 3.56, 95 % confidence intervals [CI] 1.21–29.87 and 1.11–11.39, p = 0.04 and p = 0.04, respectively). Multivariate analysis revealed that cisplatin nephrotoxicity occurred significantly more often in patients with both risk factors (OR 13.64, 95 % CI 1.11–326.83, p = 0.04). Patients with more risk factors for CKD tended to have a greater risk of developing cisplatin-induced AKI.Conclusions : We should consider avoiding administration of cisplatin to patients with CKD risk factors, particularly cardiac disease and NSAID use.

Subjects/Keywords: Cisplatin; Nephrotoxicity; Chronic kidney disease; Acute kidney injury

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sato, K. (2017). Nephrotoxicity of cisplatin combination chemotherapy in thoracic malignancy patients with CKD risk factors. : 合併症を有する胸部悪性腫瘍患者に対するシスプラチン併用化学療法の腎障害のリスク解析. (Thesis). Niigata University / 新潟大学. Retrieved from http://hdl.handle.net/10191/47613

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sato, Ko. “Nephrotoxicity of cisplatin combination chemotherapy in thoracic malignancy patients with CKD risk factors. : 合併症を有する胸部悪性腫瘍患者に対するシスプラチン併用化学療法の腎障害のリスク解析.” 2017. Thesis, Niigata University / 新潟大学. Accessed March 05, 2021. http://hdl.handle.net/10191/47613.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sato, Ko. “Nephrotoxicity of cisplatin combination chemotherapy in thoracic malignancy patients with CKD risk factors. : 合併症を有する胸部悪性腫瘍患者に対するシスプラチン併用化学療法の腎障害のリスク解析.” 2017. Web. 05 Mar 2021.

Vancouver:

Sato K. Nephrotoxicity of cisplatin combination chemotherapy in thoracic malignancy patients with CKD risk factors. : 合併症を有する胸部悪性腫瘍患者に対するシスプラチン併用化学療法の腎障害のリスク解析. [Internet] [Thesis]. Niigata University / 新潟大学; 2017. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/10191/47613.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sato K. Nephrotoxicity of cisplatin combination chemotherapy in thoracic malignancy patients with CKD risk factors. : 合併症を有する胸部悪性腫瘍患者に対するシスプラチン併用化学療法の腎障害のリスク解析. [Thesis]. Niigata University / 新潟大学; 2017. Available from: http://hdl.handle.net/10191/47613

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

22. Nakada, Yasuki; Kawakami, Rika; Matsui, Masaru; Ueda, Tomoya; Nakano, Tomoya; Takitsume, Akihiro; Nakagawa, Hitoshi; Nishida, Taku; Onoue, Kenji; Soeda, Tsunenari; Okayama, Satoshi; Watanabe, Makoto; Kawata, Hiroyuki; Okura, Hiroyuki. Prognostic Value of Urinary Neutrophil Gelatinase-Associated Lipocalin on the First Day of Admission for Adverse Events in Patients With Acute Decompensated Heart Failure. : 入院初日の尿中好中球ゼラチナーゼ結合性リポカリンは急性心不全患者の重要な予後予測因子である.

Degree: 博士（医学）, 2017, Nara Medical University / 奈良県立医科大学

URL: http://hdl.handle.net/10564/3386

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Background Urinary neutrophil gelatinase‐associated lipocalin (U‐NGAL) is an early predictor of acute kidney injury and adverse events in various diseases; however, in acute decompensated heart… (more)

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Background Urinary neutrophil gelatinase‐associated lipocalin (U‐NGAL) is an early predictor of acute kidney injury and adverse events in various diseases; however, in acute decompensated heart failure patients, its significance remains poorly understood. This study aimed to investigate the prognostic value of U‐NGAL on the first day of admission for the occurrence of acute kidney injury and long‐term outcomes in acute decompensated heart failure patients. Methods and Results We studied 260 acute decompensated heart failure patients admitted to our department between 2011 and 2014 by measuring U‐NGAL in 24‐hour urine samples collected on the first day of admission. Primary end points were all‐cause eath, cardiovascular death, and heart failure admission. Patients were divided into 2 groups according to their median U‐NGAL levels (32.5 μg/gCr). The high‐U‐NGAL group had a significantly higher occurrence of acute kidney injury during hospitalization than the low‐U‐NGAL group (P=0.0012). Kaplan‐Meier analysis revealed that the high‐U‐NGAL group exhibited a worse prognosis than the low‐U‐NGAL group in all‐cause death (hazard ratio 2.07; 95%CI 1.38‐3.12, P=0.0004), cardiovascular death (hazard ratio 2.29; 95%CI 1.28‐4.24, P=0.0052), and heart failure admission (hazard ratio 1.77; 95%CI 1.13‐2.77, P=0.0119). The addition of U‐NGAL to the estimated glomerular filtration rate significantly improved the predictive accuracy of all‐cause mortality (P=0.0083). Conclusions In acute decompensated heart failure patients, an elevated U‐NGAL level on the first day of admission was related to the development of clinical acute kidney injury and independently associated with poor prognosis.

博士（医学）・甲第675号・平成29年11月24日

Copyright & Usage: © 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License(http://creativecommons.org/licenses/by-nc/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Subjects/Keywords: acute heart failure; acute kidney injury; neutrophil gelatinase‐associated lipocalin; outcomes

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Nakada, Yasuki; Kawakami, Rika; Matsui, Masaru; Ueda, Tomoya; Nakano, Tomoya; Takitsume, Akihiro; Nakagawa, Hitoshi; Nishida, Taku; Onoue, Kenji; Soeda, Tsunenari; Okayama, Satoshi; Watanabe, Makoto; Kawata, Hiroyuki; Okura, H. (2017). Prognostic Value of Urinary Neutrophil Gelatinase-Associated Lipocalin on the First Day of Admission for Adverse Events in Patients With Acute Decompensated Heart Failure. : 入院初日の尿中好中球ゼラチナーゼ結合性リポカリンは急性心不全患者の重要な予後予測因子である. (Thesis). Nara Medical University / 奈良県立医科大学. Retrieved from http://hdl.handle.net/10564/3386

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Nakada, Yasuki; Kawakami, Rika; Matsui, Masaru; Ueda, Tomoya; Nakano, Tomoya; Takitsume, Akihiro; Nakagawa, Hitoshi; Nishida, Taku; Onoue, Kenji; Soeda, Tsunenari; Okayama, Satoshi; Watanabe, Makoto; Kawata, Hiroyuki; Okura, Hiroyuki. “Prognostic Value of Urinary Neutrophil Gelatinase-Associated Lipocalin on the First Day of Admission for Adverse Events in Patients With Acute Decompensated Heart Failure. : 入院初日の尿中好中球ゼラチナーゼ結合性リポカリンは急性心不全患者の重要な予後予測因子である.” 2017. Thesis, Nara Medical University / 奈良県立医科大学. Accessed March 05, 2021. http://hdl.handle.net/10564/3386.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Nakada, Yasuki; Kawakami, Rika; Matsui, Masaru; Ueda, Tomoya; Nakano, Tomoya; Takitsume, Akihiro; Nakagawa, Hitoshi; Nishida, Taku; Onoue, Kenji; Soeda, Tsunenari; Okayama, Satoshi; Watanabe, Makoto; Kawata, Hiroyuki; Okura, Hiroyuki. “Prognostic Value of Urinary Neutrophil Gelatinase-Associated Lipocalin on the First Day of Admission for Adverse Events in Patients With Acute Decompensated Heart Failure. : 入院初日の尿中好中球ゼラチナーゼ結合性リポカリンは急性心不全患者の重要な予後予測因子である.” 2017. Web. 05 Mar 2021.

Vancouver:

Nakada, Yasuki; Kawakami, Rika; Matsui, Masaru; Ueda, Tomoya; Nakano, Tomoya; Takitsume, Akihiro; Nakagawa, Hitoshi; Nishida, Taku; Onoue, Kenji; Soeda, Tsunenari; Okayama, Satoshi; Watanabe, Makoto; Kawata, Hiroyuki; Okura H. Prognostic Value of Urinary Neutrophil Gelatinase-Associated Lipocalin on the First Day of Admission for Adverse Events in Patients With Acute Decompensated Heart Failure. : 入院初日の尿中好中球ゼラチナーゼ結合性リポカリンは急性心不全患者の重要な予後予測因子である. [Internet] [Thesis]. Nara Medical University / 奈良県立医科大学; 2017. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/10564/3386.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Nakada, Yasuki; Kawakami, Rika; Matsui, Masaru; Ueda, Tomoya; Nakano, Tomoya; Takitsume, Akihiro; Nakagawa, Hitoshi; Nishida, Taku; Onoue, Kenji; Soeda, Tsunenari; Okayama, Satoshi; Watanabe, Makoto; Kawata, Hiroyuki; Okura H. Prognostic Value of Urinary Neutrophil Gelatinase-Associated Lipocalin on the First Day of Admission for Adverse Events in Patients With Acute Decompensated Heart Failure. : 入院初日の尿中好中球ゼラチナーゼ結合性リポカリンは急性心不全患者の重要な予後予測因子である. [Thesis]. Nara Medical University / 奈良県立医科大学; 2017. Available from: http://hdl.handle.net/10564/3386

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Queen Mary, University of London

23. Memon, Shoab Ahmed. Novel therapies in acute kidney injury.

Degree: PhD, 2015, Queen Mary, University of London

URL: http://qmro.qmul.ac.uk/xmlui/handle/123456789/8762 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667397

► Renal ischaemia-reperfusion injury (IRI) is a major cause of acute kidney injury (AKI) which is in turn the leading cause of morbidity and mortality in… (more)

▼ Renal ischaemia-reperfusion injury (IRI) is a major cause of acute kidney injury (AKI) which is in turn the leading cause of morbidity and mortality in hospitalized patients. The principle aim of this thesis was to evaluate potential new therapies that might afford protection against IRI in both in vitro and in vivo settings. Recent evidence suggests that nitrite (NO2-) may play an important role in protecting the myocardium from IRI. Our initial work into the role of NO2- in an in vitro model of renal IRI in proximal tubular epithelial cells provided evidence that NO2- can prevent apoptosis and preserve cell viability. This lead to an in vivo study where high NO2- concentrations (50 mg/L) were given orally to rats for 7 days prior to inducing renal IRI but no beneficial effects of this treatment were observed. Another potential treatment identified was thiamine (vitamin B1) and this, like NO2-was investigated to see if it had the potential to protect rats from AKI injury. It has been previously recognized that in renal IRI the high energy phosphate ATP is found to be severely depleted whilst is is known that thiamine can play a pivotal role in generating ATP. Furthermore, thiamine has previously been demonstrated to protect against myocardial ischaemic injury and has the ability to reduce myocardial infarct size. In vitro, thiamine was found to reduce the degree of apoptosis in cultured HK-2 cells caused by ischaemia whilst in vivo it afforded protection against AKI caused by renal IRI by anti-apoptotic, anti-inflammatory and anti-oxidant mechanisms. Finally, a study into the possible therapeutic role of gene therapy with bone morphogenic protein 7 (BMP-7) in renal IRI was undertaken. Previous work has established that i.v. BMP-7 is able to protect against renal IRI but it has also been associated with ectopic bone formation at the site of injection. Therefore another method to increase circulating BMP-7 was sought. We initially found that BMP-7 gene therapy could attenuate apoptosis and preserves cell viability in an in vitro model of renal IRI. However, whilst in vivo gene therapy with electroporation of BMP-7 plasmid DNA increased BMP-7 expression in mice serum 2 days post electroporation, it was unable to protect the animals against IRI induced AKI. In rats the direct injection of naked DNA BMP-7 plasmid systematic 2 days prior to renal IRI was able to upregulate BMP-7 expression 4 days later in kidney tissue. Despite this it was unable to afford protection against renal IRI. Apoptosis and necrosis play a crucial role in the pathogenesis of renal IRI induced AKI. In this thesis we investigated the role of three putative therapeutic agents and their role in apoptosis and necrosis in vitro in PTECs and in vivo against renal IRI induced AKI. All three therapeutic drugs were able to attenuate apoptosis in PTECs but were unable to protect against necrosis, whilst against renal IRI induced AKI only thiamine was found to be protective. Thiamine appears to hold the most promise and more work needs to be undertaken so…

Subjects/Keywords: 616.6; Translational Medicine & Therapeutics; Acute Kidney Injury; ischaemia-reperfusion injury

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APA (6^th Edition):

Memon, S. A. (2015). Novel therapies in acute kidney injury. (Doctoral Dissertation). Queen Mary, University of London. Retrieved from http://qmro.qmul.ac.uk/xmlui/handle/123456789/8762 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667397

Chicago Manual of Style (16^th Edition):

Memon, Shoab Ahmed. “Novel therapies in acute kidney injury.” 2015. Doctoral Dissertation, Queen Mary, University of London. Accessed March 05, 2021. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8762 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667397.

MLA Handbook (7^th Edition):

Memon, Shoab Ahmed. “Novel therapies in acute kidney injury.” 2015. Web. 05 Mar 2021.

Vancouver:

Memon SA. Novel therapies in acute kidney injury. [Internet] [Doctoral dissertation]. Queen Mary, University of London; 2015. [cited 2021 Mar 05]. Available from: http://qmro.qmul.ac.uk/xmlui/handle/123456789/8762 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667397.

Council of Science Editors:

Memon SA. Novel therapies in acute kidney injury. [Doctoral Dissertation]. Queen Mary, University of London; 2015. Available from: http://qmro.qmul.ac.uk/xmlui/handle/123456789/8762 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667397

University of Melbourne

24. O'Kane, Dermot Bernard. Protection of the kidney against Ischaemia-Reperfusion injury using zinc.

Degree: 2019, University of Melbourne

URL: http://hdl.handle.net/11343/235624

► Acute kidney injury (AKI) continues to be a major cause of morbidity and mortality worldwide. Septic shock, hypovolaemia, and renal ischaemia related to major surgeries… (more)

▼ Acute kidney injury (AKI) continues to be a major cause of morbidity and mortality worldwide. Septic shock, hypovolaemia, and renal ischaemia related to major surgeries are the primary contributors to AKI in hospitalised patients. AKI is associated with a four-fold increase in mortality in hospitalised patients, and a two-fold increase in the likelihood of discharge to a short- or long-term care facility. As a result, the estimated healthcare costs associated with AKI in hospitalised patients in the US alone exceeds US$10billion per year. Studies have also demonstrated that AKI resulting from ischaemia-reperfusion (IR) is a causative determinant in the development, and progression, of chronic kidney disease (CKD). Despite major medical advances to the current day, short of supportive measures there is still no definitive therapeutic option available to prevent AKI in these settings. Preconditioning (PC) against renal IR injury has been heralded as a promising solution to abrogate this major healthcare problem, and an extensive volume of research has amassed in this area. Preconditioning is a phenomenon whereby an innate tissue adaptation occurs in response to a sublethal stimulus, which leads to protection of an organ or tissue against a subsequent insult. PC was first discovered in the context of ischaemic PC (IPC), where brief sublethal periods of ischaemia led to protection against a subsequent more sustained period of ischaemia in the canine heart. Since the discovery of the IPC phenomenon in 1986, tissue protection against ischaemia by means of IPC has been demonstrated by a number of methods in a variety of tissues, including the heart, brain, liver, kidney, and striated smooth muscle. The promise of these findings has also prompted research into the use of alternative methods of tissue PC, and studies have since investigated the use of pharmaceutical agents to promote these tissue adaptations by pharmacological preconditioning (PPC). The race for a pharmaceutical agent capable of eliciting protective adaptations against tissue ischaemia has involved many classes of pharmaceutical compounds, endogenous proteins, and trace elements. Zinc (Zn) is a metal that is essential to many biological functions, including cell growth and survival. The omnipresence of Zn in cellular interactions, and its importance in so many biological processes has led to the investigation of augmenting Zn homeostasis as a means of protection against tissue ischaemia. This is the primary topic of this thesis. The promise of enabling organ protection against IR injury has major clinical implications, spanning many areas of medicine. However, despite the extensive volume of clinical and basic science research in this area, there is still currently no effective method of PC that will protect the human kidney against IR injury. The aims of this thesis are to investigate if parenteral Zn can be used as a therapeutic strategy to protect the kidney against IR injury. The body of research on the topic of tissue PC has highlighted some…

Subjects/Keywords: Preconditioning; Ischaemia-reperfusion injury; Acute kidney injury; Zinc; Succinate

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APA (6^th Edition):

O'Kane, D. B. (2019). Protection of the kidney against Ischaemia-Reperfusion injury using zinc. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/235624

Chicago Manual of Style (16^th Edition):

O'Kane, Dermot Bernard. “Protection of the kidney against Ischaemia-Reperfusion injury using zinc.” 2019. Doctoral Dissertation, University of Melbourne. Accessed March 05, 2021. http://hdl.handle.net/11343/235624.

MLA Handbook (7^th Edition):

O'Kane, Dermot Bernard. “Protection of the kidney against Ischaemia-Reperfusion injury using zinc.” 2019. Web. 05 Mar 2021.

Vancouver:

O'Kane DB. Protection of the kidney against Ischaemia-Reperfusion injury using zinc. [Internet] [Doctoral dissertation]. University of Melbourne; 2019. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/11343/235624.

Council of Science Editors:

O'Kane DB. Protection of the kidney against Ischaemia-Reperfusion injury using zinc. [Doctoral Dissertation]. University of Melbourne; 2019. Available from: http://hdl.handle.net/11343/235624

University of Minnesota

25. Gisewhite, Sarah. Assessment Of Urinary Metabolites In Risk Prediction Of Acute Kidney Injury.

Degree: MS, Integrated Biosciences, 2020, University of Minnesota

URL: http://hdl.handle.net/11299/214994

► Acute kidney injury (AKI) is the sudden decrease or loss of kidney function caused by direct kidney injury or functional impairment. Many patients do not… (more)

Subjects/Keywords: acute kidney injury; biomarkers; combat injury; metabolites; NMR; risk prediction

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APA (6^th Edition):

Gisewhite, S. (2020). Assessment Of Urinary Metabolites In Risk Prediction Of Acute Kidney Injury. (Masters Thesis). University of Minnesota. Retrieved from http://hdl.handle.net/11299/214994

Chicago Manual of Style (16^th Edition):

Gisewhite, Sarah. “Assessment Of Urinary Metabolites In Risk Prediction Of Acute Kidney Injury.” 2020. Masters Thesis, University of Minnesota. Accessed March 05, 2021. http://hdl.handle.net/11299/214994.

MLA Handbook (7^th Edition):

Gisewhite, Sarah. “Assessment Of Urinary Metabolites In Risk Prediction Of Acute Kidney Injury.” 2020. Web. 05 Mar 2021.

Vancouver:

Gisewhite S. Assessment Of Urinary Metabolites In Risk Prediction Of Acute Kidney Injury. [Internet] [Masters thesis]. University of Minnesota; 2020. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/11299/214994.

Council of Science Editors:

Gisewhite S. Assessment Of Urinary Metabolites In Risk Prediction Of Acute Kidney Injury. [Masters Thesis]. University of Minnesota; 2020. Available from: http://hdl.handle.net/11299/214994

26. Wei, Jin. Acute Kidney Injury and Chronic Kidney Disease.

Degree: 2017, University of South Florida

URL: https://scholarcommons.usf.edu/etd/6780

► Ischemia and reperfusion are natural steps during kidney transplantation, and IRI is considered one of the most important nonspecific factors affecting allograft dysfunction. Transplanted organs… (more)

Subjects/Keywords: Acute Kidney Injury; Ischemia Reperfusion Injury; Chronic Kidney Disease; Renal Hemodynamic; Physiology

11 more images…

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APA (6^th Edition):

Wei, J. (2017). Acute Kidney Injury and Chronic Kidney Disease. (Thesis). University of South Florida. Retrieved from https://scholarcommons.usf.edu/etd/6780

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wei, Jin. “Acute Kidney Injury and Chronic Kidney Disease.” 2017. Thesis, University of South Florida. Accessed March 05, 2021. https://scholarcommons.usf.edu/etd/6780.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wei, Jin. “Acute Kidney Injury and Chronic Kidney Disease.” 2017. Web. 05 Mar 2021.

Vancouver:

Wei J. Acute Kidney Injury and Chronic Kidney Disease. [Internet] [Thesis]. University of South Florida; 2017. [cited 2021 Mar 05]. Available from: https://scholarcommons.usf.edu/etd/6780.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wei J. Acute Kidney Injury and Chronic Kidney Disease. [Thesis]. University of South Florida; 2017. Available from: https://scholarcommons.usf.edu/etd/6780

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Penn State University

27. Wang, Luojun. The Joint Modeling of Recurrent Events and Other Failure Time Events.

Degree: 2016, Penn State University

URL: https://submit-etda.libraries.psu.edu/catalog/xd07gs69t

► Recurrent events are commonly encountered in biomedical research studies and clinical trials. Many previous studies are done to investigate recurrent event analysis. As introduced in… (more)

▼ Recurrent events are commonly encountered in biomedical research studies and clinical trials. Many previous studies are done to investigate recurrent event analysis. As introduced in Chapter 1, some of the early work on recurrent event focuses on survival outcomes and others on longitudinal outcomes. If recurrent events are correlated with a failure event, such as death, we no longer should assume independent censoring. Many reports in the literature incorporate a latent variable model to account for the correlation between the time to event T and the number of recurrent events N(t). We fi�rst jointly model the time to primary outcome and the number of recurrent events with the frailty model, using a Zero-inflated-Poisson-Weibull distribution. We develop the analytical forms and details in the full parametric setting; however, such a model may be over-parameterized and di�cult to apply, which limits us from applying full likelihood-based analyses. Because of the limitation of the frailty model, we propose a joint distribution for (T;N) based on conditional distributions. We illustrate the use of this joint distribution to model the recurrent events of acute kidney injury (AKI) and time to primary outcome (death) in patients with and without chronic kidney disease (CKD) and AKI. In this fully parametric model, we develop the intensity ratio for the recurrent events and the hazard ratios for the failure event among different groups of patients with or without an AKI event at the index hospitalization and with or without CKD at the index hospitalization. Based on our model, we then investigate if recurrent AKI is predictive of death. Further, we are interested in a non-terminal event, such as End Stage Renal Disease (ESRD), which may be censored by a terminal event (Death), but not vice versa. The previous methods, such as a cause-speci�c hazards model and a subdistribution hazards model are based on the independence assumption, which is not appropriate in such case. Therefore, we introduce and develop a semi competing risk approach with a Gaussian copula, using the tri-variate Weibull distribution. Then we illustrate the results from di�fferent approaches with a simulated data example. Finally, we compare di�fferent tri-variate Weibull distributions with Gaussian copula, Clayton copula or under independence, via a series of simulation studies. Two sets of data are generated by tri-variate Weibull distributions with either Gaussian or Clayton copula, to test the bias of performances with each method. Advisors/Committee Members: Vernon Michael Chinchilli, Dissertation Advisor/Co-Advisor, Vernon Michael Chinchilli, Committee Chair/Co-Chair, David Theodore Mauger, Committee Member, Lan Kong, Committee Member, Laura Carrel, Outside Member.

Subjects/Keywords: survival analysis; joint modeling; semi-competing risks; recurrent events; acute kidney injury; tri-vairate Weibull; acute kidney injury; tri-variate Weibull

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APA (6^th Edition):

Wang, L. (2016). The Joint Modeling of Recurrent Events and Other Failure Time Events. (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/xd07gs69t

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wang, Luojun. “The Joint Modeling of Recurrent Events and Other Failure Time Events.” 2016. Thesis, Penn State University. Accessed March 05, 2021. https://submit-etda.libraries.psu.edu/catalog/xd07gs69t.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wang, Luojun. “The Joint Modeling of Recurrent Events and Other Failure Time Events.” 2016. Web. 05 Mar 2021.

Vancouver:

Wang L. The Joint Modeling of Recurrent Events and Other Failure Time Events. [Internet] [Thesis]. Penn State University; 2016. [cited 2021 Mar 05]. Available from: https://submit-etda.libraries.psu.edu/catalog/xd07gs69t.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wang L. The Joint Modeling of Recurrent Events and Other Failure Time Events. [Thesis]. Penn State University; 2016. Available from: https://submit-etda.libraries.psu.edu/catalog/xd07gs69t

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Arizona

28. Montoya, Jesse Alan. Blood Product Administration and Kidney Function as a Mortality Indicator for VA-ECMO: A Retrospective Review of a Single Institution .

Degree: 2019, University of Arizona

URL: http://hdl.handle.net/10150/633245

► Background Veno-arterial extracorporeal membrane oxygenation (VA ECMO) is a rapidly growing treatment for critically ill patients. The management of this life-saving therapy is extremely complicated;… (more)

▼ Background Veno-arterial extracorporeal membrane oxygenation (VA ECMO) is a rapidly growing treatment for critically ill patients. The management of this life-saving therapy is extremely complicated; requiring highly trained professionals in the intensive care unit. Since the epidemic of influenza A in 2009, the usage of ECMO has increased by a 1000 fold. Unfortunately, the research and data is not able to keep up. Herein, we aim to increase this data with our own and look for markers that show an increase risk of mortality. We especially want to take note of blood product usage, kidney function, and patient platelet counts as indicators for increased mortality. Methods This is a retrospective analysis of patients that underwent VA ECMO treatment at Banner University Medical Center – Tucson, during the time period of January 2010 – December 2015. We disqualified patients that were on VA ECMO for less than 22 hours, as we felt this was not long enough of a time period to allow the changes we were hoping to discern. Data from the remaining 70 patients (32F/38M), median age 44 (11 – 61.5) years, was obtained by chart review. Patients were separated into two groups: those who survived until discharge (survivors, N = 25), and those who did not (nonsurvivors, N = 45). Results Our VA ECMO survival rates are 35.7% for our included patients. Nonsurvivors had much higher rates of receiving CRRT (64.4% vs 20.0%, p < 0.001) and higher initial (22 vs 18, p = 0.030) and average (31 vs 21, p = .023) BUN values than the survivors. Non survivors also received much more pRBCs (3451 vs 2080 ml, p = 0.003), platelets (1900 vs 556 ml, p = 0.003) and FFP (1123 vs 240 ml, p = .001) over the course of their run than survivors. There was no significant difference in any measured platelet counts between patients. Conclusions Patients that receive increased blood product administration and reduced kidney function during VA ECMO are at an increased risk of mortality. Further studies are required to further elucidate markers of ECMO outcomes that can guide the practice. Advisors/Committee Members: Vanderah, Todd (advisor), Tran, Phat (advisor), Cosgrove, Richard (committeemember), Chen, Qin (committeemember).

Subjects/Keywords: AKI; ECMO; Kidney; Mortality; Product; VA ECMO

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APA (6^th Edition):

Montoya, J. A. (2019). Blood Product Administration and Kidney Function as a Mortality Indicator for VA-ECMO: A Retrospective Review of a Single Institution . (Masters Thesis). University of Arizona. Retrieved from http://hdl.handle.net/10150/633245

Chicago Manual of Style (16^th Edition):

Montoya, Jesse Alan. “Blood Product Administration and Kidney Function as a Mortality Indicator for VA-ECMO: A Retrospective Review of a Single Institution .” 2019. Masters Thesis, University of Arizona. Accessed March 05, 2021. http://hdl.handle.net/10150/633245.

MLA Handbook (7^th Edition):

Montoya, Jesse Alan. “Blood Product Administration and Kidney Function as a Mortality Indicator for VA-ECMO: A Retrospective Review of a Single Institution .” 2019. Web. 05 Mar 2021.

Vancouver:

Montoya JA. Blood Product Administration and Kidney Function as a Mortality Indicator for VA-ECMO: A Retrospective Review of a Single Institution . [Internet] [Masters thesis]. University of Arizona; 2019. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/10150/633245.

Council of Science Editors:

Montoya JA. Blood Product Administration and Kidney Function as a Mortality Indicator for VA-ECMO: A Retrospective Review of a Single Institution . [Masters Thesis]. University of Arizona; 2019. Available from: http://hdl.handle.net/10150/633245

University of Minnesota

29. Li, Shuling. Association Between Adjuvant Chemotherapy and Nephrotoxicity and Kidney Function Monitoring in Elderly Breast Cancer Patients.

Degree: PhD, Epidemiology, 2013, University of Minnesota

URL: http://hdl.handle.net/11299/173925

► Background: Chronic kidney disease (CKD) and cancer are major public health problems in the elderly population. In elderly cancer patients, little is known about chemotherapy-related… (more)

▼ Background: Chronic kidney disease (CKD) and cancer are major public health problems in the elderly population. In elderly cancer patients, little is known about chemotherapy-related nephrotoxicity or patterns of CKD screening. The purpose of this dissertation was to evaluate the association between adjuvant chemotherapy (CHEMO) and risks of acute kidney injury (AKI) and CKD and rate of CKD screening in elderly women diagnosed with stages I-III breast cancer. Methods: The study was a 1:1 individually matched, retrospective cohort design using Surveillance, Epidemiology, and End Results (SEER)-Medicare linked data. Matching was performed at the day of CHEMO initiation based on propensity score. The assembled matched cohorts were used in the analyses for all three objectives with different follow-up periods and statistical methods for each objective. HASH(0x307f974) Results: A total of 28,048 patients were included. CHEMO was associated with a 2.7-fold increased risk of AKI within 6 months after initiation (HR 2.7, 95% CI 1.8-4.1). To find a possible explanation to this association, the distribution of other diseases coded on hospital claims for AKI was examined and showed that septicemia occurred in 40% of CHEMO treated patients with AKI and in only 17% of untreated patients with AKI. No significant association was found between CHEMO and risk of CKD in the maximum 18 years follow-up (HR 1.00, 95% CI 0.93-1.07). The rate of CKD screening after treatment completion was low regardless of CHEMO status. HASH(0x2faf9d4) Conclusion: CHEMO is associated with increased risk of AKI. This association may be partially explained by septicemia caused by infection/neutropenia due to use of myelosuppressive chemotherapeutic agents, which highlights the importance of preventing serious complications of CHEMO in preventing AKI. The finding of no association between CHEMO and risk of CKD may not suggest a late nephrotoxic effect of chemotherapeutic agents commonly used to treat breast cancer in the adjuvant setting, or provide evidence to recommend a clinical practice guideline for CKD screening specifically in elderly breast cancer patients treated with CHEMO. Future studies of CKD as a late effect of cancer treatment for other solid tumors commonly treated with known or potential nephrotoxic agents are warranted.

Subjects/Keywords: Acute kidney injury; Breast cancer; Chemotherapy; Chronic kidney disease; CKD screening; Nephrotoxicity

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APA (6^th Edition):

Li, S. (2013). Association Between Adjuvant Chemotherapy and Nephrotoxicity and Kidney Function Monitoring in Elderly Breast Cancer Patients. (Doctoral Dissertation). University of Minnesota. Retrieved from http://hdl.handle.net/11299/173925

Chicago Manual of Style (16^th Edition):

Li, Shuling. “Association Between Adjuvant Chemotherapy and Nephrotoxicity and Kidney Function Monitoring in Elderly Breast Cancer Patients.” 2013. Doctoral Dissertation, University of Minnesota. Accessed March 05, 2021. http://hdl.handle.net/11299/173925.

MLA Handbook (7^th Edition):

Li, Shuling. “Association Between Adjuvant Chemotherapy and Nephrotoxicity and Kidney Function Monitoring in Elderly Breast Cancer Patients.” 2013. Web. 05 Mar 2021.

Vancouver:

Li S. Association Between Adjuvant Chemotherapy and Nephrotoxicity and Kidney Function Monitoring in Elderly Breast Cancer Patients. [Internet] [Doctoral dissertation]. University of Minnesota; 2013. [cited 2021 Mar 05]. Available from: http://hdl.handle.net/11299/173925.

Council of Science Editors:

Li S. Association Between Adjuvant Chemotherapy and Nephrotoxicity and Kidney Function Monitoring in Elderly Breast Cancer Patients. [Doctoral Dissertation]. University of Minnesota; 2013. Available from: http://hdl.handle.net/11299/173925

Louisiana State University

30. R. Nair, Anand. Toll-like Receptor 4 (TLR4) in Acute and Chronic Renal Diseases.

Degree: PhD, Medicine and Health Sciences, 2015, Louisiana State University

URL: etd-04062015-100633 ; https://digitalcommons.lsu.edu/gradschool_dissertations/3632

► Despite advances in its treatment, the incidence of renal diseases has been consistently increasing. Hence, there is a need to understand the underlying molecular mechanisms… (more)

▼ Despite advances in its treatment, the incidence of renal diseases has been consistently increasing. Hence, there is a need to understand the underlying molecular mechanisms of the progression of kidney diseases. Recent research implicates inflammation as an important mediator of renal injury. We hypothesized that inhibiting Toll-like receptor 4 (TLR4), an upstream modulator of several inflammatory pathways, would prevent the progression of renal diseases. First, we determined the mechanism by which AngiotensinII (AngII)-induced inflammation is modulated by TLR4 using an in vitro model of rat tubulo-epithelial cells. We blocked TLR4 using gene silencing strategy in NRK52E cells. In TLR4-silenced cells, the expression of TLR4 was decreased, activation of NF-κB was reduced, inflammation and oxidative stress were attenuated, suggesting a role for TLR4 in potentiating AngII-induced renal inflammation. We then focused on an in vivo acute kidney injury (AKI) model to elucidate the effect of TLR4 in AKI. We used lipopolysaccharide (LPS), a specific ligand of TLR4, to induce AKI. We injected one group of rats with VIPER, a TLR4 inhibitory peptide, before LPS administration. We also used blueberry as a non-pharmacological approach to study if blueberry could protect against LPS-induced AKI. Compared to LPS-administered rats, the BB-pretreated animals exhibited improved renal hemodynamics, attenuated expression of TLR4 and inflammation. The results in the BB-pretreated group were consistent with the VIPER-treated rats. This indicates that TLR4 is an important mediator in LPS-induced AKI, and suggest that BB, by inhibiting TLR4, is a viable non-pharmacological option to decrease AKI. We also examined the effect of TLR4 signaling and its downstream mechanism in an animal model of metabolic syndrome-associated chronic kidney disease (CKD) and investigated if a blueberry-enriched diet could attenuate the progression of CKD. We showed that OZR exhibited lower glucose tolerance, exacerbated renal dysfunction and increased oxidative stress. Expression levels of TLR4 and, phosphorylation of ERK and p38MAPK were higher. This was accompanied by increased renal pathology. BB-fed OZR showed significant improvements in all of these parameters. This suggests that the TLR4-MAPK signaling pathway is a key to the renal dysfunction in MetS, and BB protects against this damage by inhibiting TLR4.

Subjects/Keywords: acute kidney injury; chronic kidney disease; renal disease; inflammation; TLR4; oxidative stress

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APA (6^th Edition):

R. Nair, A. (2015). Toll-like Receptor 4 (TLR4) in Acute and Chronic Renal Diseases. (Doctoral Dissertation). Louisiana State University. Retrieved from etd-04062015-100633 ; https://digitalcommons.lsu.edu/gradschool_dissertations/3632

Chicago Manual of Style (16^th Edition):

R. Nair, Anand. “Toll-like Receptor 4 (TLR4) in Acute and Chronic Renal Diseases.” 2015. Doctoral Dissertation, Louisiana State University. Accessed March 05, 2021. etd-04062015-100633 ; https://digitalcommons.lsu.edu/gradschool_dissertations/3632.

MLA Handbook (7^th Edition):

R. Nair, Anand. “Toll-like Receptor 4 (TLR4) in Acute and Chronic Renal Diseases.” 2015. Web. 05 Mar 2021.

Vancouver:

R. Nair A. Toll-like Receptor 4 (TLR4) in Acute and Chronic Renal Diseases. [Internet] [Doctoral dissertation]. Louisiana State University; 2015. [cited 2021 Mar 05]. Available from: etd-04062015-100633 ; https://digitalcommons.lsu.edu/gradschool_dissertations/3632.

Council of Science Editors:

R. Nair A. Toll-like Receptor 4 (TLR4) in Acute and Chronic Renal Diseases. [Doctoral Dissertation]. Louisiana State University; 2015. Available from: etd-04062015-100633 ; https://digitalcommons.lsu.edu/gradschool_dissertations/3632

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Open Access Theses and Dissertations