subject:(action potential)

1. 箕輪, 弘嗣. 極短パルスレーザー光による第二次高調波発生を利用した局所静電場計測 : Local mesurement of electric field by second harmonic generation stimulated with femtosectond-pulse laser light; ゴクタンパルスレーザーコウニヨルダイニジコウチョウハハッセイオリヨウシタキョクショセイデンバケイソク.

Degree: Nara Institute of Science and Technology / 奈良先端科学技術大学院大学

URL: http://hdl.handle.net/10061/1533

Subjects/Keywords: Action potential

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APA (6^th Edition):

箕輪, �. (n.d.). 極短パルスレーザー光による第二次高調波発生を利用した局所静電場計測 : Local mesurement of electric field by second harmonic generation stimulated with femtosectond-pulse laser light; ゴクタンパルスレーザーコウニヨルダイニジコウチョウハハッセイオリヨウシタキョクショセイデンバケイソク. (Thesis). Nara Institute of Science and Technology / 奈良先端科学技術大学院大学. Retrieved from http://hdl.handle.net/10061/1533

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

箕輪, 弘嗣. “極短パルスレーザー光による第二次高調波発生を利用した局所静電場計測 : Local mesurement of electric field by second harmonic generation stimulated with femtosectond-pulse laser light; ゴクタンパルスレーザーコウニヨルダイニジコウチョウハハッセイオリヨウシタキョクショセイデンバケイソク.” Thesis, Nara Institute of Science and Technology / 奈良先端科学技術大学院大学. Accessed April 22, 2021. http://hdl.handle.net/10061/1533.

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

箕輪, 弘嗣. “極短パルスレーザー光による第二次高調波発生を利用した局所静電場計測 : Local mesurement of electric field by second harmonic generation stimulated with femtosectond-pulse laser light; ゴクタンパルスレーザーコウニヨルダイニジコウチョウハハッセイオリヨウシタキョクショセイデンバケイソク.” Web. 22 Apr 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

箕輪 �. 極短パルスレーザー光による第二次高調波発生を利用した局所静電場計測 : Local mesurement of electric field by second harmonic generation stimulated with femtosectond-pulse laser light; ゴクタンパルスレーザーコウニヨルダイニジコウチョウハハッセイオリヨウシタキョクショセイデンバケイソク. [Internet] [Thesis]. Nara Institute of Science and Technology / 奈良先端科学技術大学院大学; [cited 2021 Apr 22]. Available from: http://hdl.handle.net/10061/1533.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

箕輪 �. 極短パルスレーザー光による第二次高調波発生を利用した局所静電場計測 : Local mesurement of electric field by second harmonic generation stimulated with femtosectond-pulse laser light; ゴクタンパルスレーザーコウニヨルダイニジコウチョウハハッセイオリヨウシタキョクショセイデンバケイソク. [Thesis]. Nara Institute of Science and Technology / 奈良先端科学技術大学院大学; Available from: http://hdl.handle.net/10061/1533

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Dalhousie University

2. Adamczyk, Andrew. CHARACTERIZATION OF THE PHOSPHODIESTERASE SUBTYPES THAT REGULATE MOUSE ATRIAL MYOCYTE ELECTROPHYSIOLOGY.

Degree: MS, Department of Physiology & Biophysics, 2012, Dalhousie University

URL: http://hdl.handle.net/10222/15708

► Phosphodiesterases (PDEs) are the enzymes responsible for the hydrolysis of cyclic nucleotides including cAMP and cGMP. We recently discovered that natriuretic peptides elicit effects in… (more)

Subjects/Keywords: Electrophysiology; Cardiomyocyte; Action Potential; Calcium Current; Phosphodiesterase

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APA (6^th Edition):

Adamczyk, A. (2012). CHARACTERIZATION OF THE PHOSPHODIESTERASE SUBTYPES THAT REGULATE MOUSE ATRIAL MYOCYTE ELECTROPHYSIOLOGY. (Masters Thesis). Dalhousie University. Retrieved from http://hdl.handle.net/10222/15708

Chicago Manual of Style (16^th Edition):

Adamczyk, Andrew. “CHARACTERIZATION OF THE PHOSPHODIESTERASE SUBTYPES THAT REGULATE MOUSE ATRIAL MYOCYTE ELECTROPHYSIOLOGY.” 2012. Masters Thesis, Dalhousie University. Accessed April 22, 2021. http://hdl.handle.net/10222/15708.

MLA Handbook (7^th Edition):

Adamczyk, Andrew. “CHARACTERIZATION OF THE PHOSPHODIESTERASE SUBTYPES THAT REGULATE MOUSE ATRIAL MYOCYTE ELECTROPHYSIOLOGY.” 2012. Web. 22 Apr 2021.

Vancouver:

Adamczyk A. CHARACTERIZATION OF THE PHOSPHODIESTERASE SUBTYPES THAT REGULATE MOUSE ATRIAL MYOCYTE ELECTROPHYSIOLOGY. [Internet] [Masters thesis]. Dalhousie University; 2012. [cited 2021 Apr 22]. Available from: http://hdl.handle.net/10222/15708.

Council of Science Editors:

Adamczyk A. CHARACTERIZATION OF THE PHOSPHODIESTERASE SUBTYPES THAT REGULATE MOUSE ATRIAL MYOCYTE ELECTROPHYSIOLOGY. [Masters Thesis]. Dalhousie University; 2012. Available from: http://hdl.handle.net/10222/15708

University of Louisville

3. Kilfoil, Peter Joseph. Modulation of cardiac Kv currents by Kvbeta2 and pyridine nucleotides.

Degree: PhD, 2016, University of Louisville

URL: 10.18297/etd/2400 ; https://ir.library.louisville.edu/etd/2400

► Myocardial voltage-gated potassium (Kv) channels regulate the resting membrane potential and the repolarization phase of the action potential. Members of the Kv1 and Kv4… (more)

▼ Myocardial voltage-gated potassium (Kv) channels regulate the resting membrane potential and the repolarization phase of the action potential. Members of the Kv1 and Kv4 family associate with ancillary subunits, such as the Kvβ proteins, that modify channel kinetics, gating and trafficking. Previous investigation into the function of cardiac β subunits demonstrated that Kvβ1 regulates I_to and I_K,slowcurrents in the heart, but the role of Kvβ2 in the myocardium remains unknown. In heterologous expression systems, Kvβ2 increases surface expression of Kv1 channels, shifts the activation potential of Kv1 channels to more polarized voltages, and increases the inactivation of Kv1 channels. Accordingly, the electrophysiological phenotype in Kvβ2^-/- mice was examined to uncover its role. To investigate the effects of the loss of Kvβ2 on cardiac repolarization, we performed whole-cell electrophysiology on primary cardiac myocytes. We found Kv current density was reduced and action potential duration prolonged in myocytes lacking Kvβ2. To isolate the molecular interactions by which Kvβ2 was affecting Kv currents, we show that Kvβ2 co-immunoprecipitates with Kv1.4 and Kv1.5 in heart lysates. To measure if surface expression of these Kv channels was reduced with the loss of Kvβ2, we performed immunofluorescent confocal microscopy of isolated cardiac myocytes. We found that the surface expression of Kv1.5 was reduced in Kvβ2^-/- myocytes. We also performed a membrane fractionation technique to demonstrate that the proportion of total cellular Kv1.5 at the membrane was reduced in Kvβ2^-/-. Together, these findings support our hypothesis that Kvβ2 plays a role in the generation of functional Kv currents in the myocardium by interacting with members of the Kv family. The pyridine nucleotides, NAD[P](H), are ubiquitous cofactors utilized as electron donors and acceptors by over 250 cellular oxidoreductases. Work out of our laboratory has shown that the Kvβ proteins are functional enzymes of the aldo-keto reductase family, that utilize NAD[P]H to catalyze the reduction of substrates. Furthermore, follow up work has shown that the redox status of bound pyridine nucleotide (PN) modifies the gating of Kvα-Kvβ channel complexes in heterologous expression systems. To examine a physiological role for PN in cardiac repolarization, whole-cell and single channel cardiac myocyte currents were recorded under the exposure to various PN redox states. We found that the inactivation rates and open probabilities of Kv currents in isolated myocytes are sensitive to the redox status of PN, and that surface action potentials in an isolated heart model are prolonged by treatment with factors that increase intracellular NADH concentration. Advisors/Committee Members: Bhatnagar, Aruni, Gregg, Ronald, Gregg, Ronald, Conklin, Daniel, Clark, Barbara, Cheng, Alan.

Subjects/Keywords: electrophysiology; action potential; potassium; cardiomyocyte; repolarization; Cardiology

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APA (6^th Edition):

Kilfoil, P. J. (2016). Modulation of cardiac Kv currents by Kvbeta2 and pyridine nucleotides. (Doctoral Dissertation). University of Louisville. Retrieved from 10.18297/etd/2400 ; https://ir.library.louisville.edu/etd/2400

Chicago Manual of Style (16^th Edition):

Kilfoil, Peter Joseph. “Modulation of cardiac Kv currents by Kvbeta2 and pyridine nucleotides.” 2016. Doctoral Dissertation, University of Louisville. Accessed April 22, 2021. 10.18297/etd/2400 ; https://ir.library.louisville.edu/etd/2400.

MLA Handbook (7^th Edition):

Kilfoil, Peter Joseph. “Modulation of cardiac Kv currents by Kvbeta2 and pyridine nucleotides.” 2016. Web. 22 Apr 2021.

Vancouver:

Kilfoil PJ. Modulation of cardiac Kv currents by Kvbeta2 and pyridine nucleotides. [Internet] [Doctoral dissertation]. University of Louisville; 2016. [cited 2021 Apr 22]. Available from: 10.18297/etd/2400 ; https://ir.library.louisville.edu/etd/2400.

Council of Science Editors:

Kilfoil PJ. Modulation of cardiac Kv currents by Kvbeta2 and pyridine nucleotides. [Doctoral Dissertation]. University of Louisville; 2016. Available from: 10.18297/etd/2400 ; https://ir.library.louisville.edu/etd/2400

Vanderbilt University

4. Drake, Kenneth James. Glutamine and glutamate limit the shortening of cardiac action potential during and after ischemia and anoxia.

Degree: PhD, Molecular Physiology and Biophysics, 2015, Vanderbilt University

URL: http://hdl.handle.net/1803/14574

► The heart must function properly to perform its essential role in supplying the body with the oxygen and nutrients required for survival. Over the course… (more)

▼ The heart must function properly to perform its essential role in supplying the body with the oxygen and nutrients required for survival. Over the course of a lifetime the heart will eventually be exposed to conditions of oxygen depletion or obstructed flow. At such times it is essential that the heart maintain its function and adapt to these conditions by altering its metabolism in response to the decrease in oxygen. Glucose, fatty acids, lactate and most other substrates require oxygen for full energy yield, making them unsuitable during an anoxic or ischemic period. Amino acids have a wide array of uses in the body, including as metabolic substrates. In particular, glutamine and glutamate can be easily converted to α-ketoglutarate and shuttled into the TCA cycle as metabolic substrates. For this reason we hypothesized that it may be possible to prolong cardiac function during – and improve recovery after – oxygen depletion by supplying the heart with excess glutamine and glutamate. Using action potential duration (APD) as a readout for the electrical function of the heart, we exposed rabbit hearts to anoxic and ischemic challenges and monitored their behavior. We show that elevated levels of glutamate and glutamine increased APD90 in anoxic hearts by 11% over controls. In ischemic hearts, however, the effects were even greater, as the enriched hearts had a 29% increase in APD90 and a 38% increase in APD50 compared to controls. We also demonstrate that blockage of amino acid transamination eliminates this effect and show that metabolism of these amino acids through the TCA cycle is the primary mechanism. These results are significant and conserved across both anoxia and ischemia, indicating that this could be a reliable and effective intervention for extending APD and possibly improving cardiac function. Advisors/Committee Members: Owen McGuinness (committee member), John McLean (committee member), David Wasserman (committee member), Jamey Young (committee member), Tony Weil (Committee Chair).

Subjects/Keywords: action potential; amino acids; glutamine; Cardiac; glutamate

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APA (6^th Edition):

Drake, K. J. (2015). Glutamine and glutamate limit the shortening of cardiac action potential during and after ischemia and anoxia. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/14574

Chicago Manual of Style (16^th Edition):

Drake, Kenneth James. “Glutamine and glutamate limit the shortening of cardiac action potential during and after ischemia and anoxia.” 2015. Doctoral Dissertation, Vanderbilt University. Accessed April 22, 2021. http://hdl.handle.net/1803/14574.

MLA Handbook (7^th Edition):

Drake, Kenneth James. “Glutamine and glutamate limit the shortening of cardiac action potential during and after ischemia and anoxia.” 2015. Web. 22 Apr 2021.

Vancouver:

Drake KJ. Glutamine and glutamate limit the shortening of cardiac action potential during and after ischemia and anoxia. [Internet] [Doctoral dissertation]. Vanderbilt University; 2015. [cited 2021 Apr 22]. Available from: http://hdl.handle.net/1803/14574.

Council of Science Editors:

Drake KJ. Glutamine and glutamate limit the shortening of cardiac action potential during and after ischemia and anoxia. [Doctoral Dissertation]. Vanderbilt University; 2015. Available from: http://hdl.handle.net/1803/14574

University of Minnesota

5. McIntyre, Stephen. Understand and analyzing APD alternans.

Degree: PhD, Mathematics, 2015, University of Minnesota

URL: http://hdl.handle.net/11299/175691

► A beat-to-beat alternation in the action potential duration (APD) of myocytes, i.e. alternans, is believed to be a direct precursor of ventricular fibrillation in the… (more)

▼ A beat-to-beat alternation in the action potential duration (APD) of myocytes, i.e. alternans, is believed to be a direct precursor of ventricular fibrillation in the whole heart. A common approach for the prediction of alternans is to construct the restitution curve, which is the nonlinear functional relationship between the APD and the preceding diastolic interval (DI). It was proposed that alternans appears when the magnitude of the slope of the restitution curve exceeds one, known as the restitution hypothesis. In this thesis we aim at understanding the spatio-temporal formation of alternans. Our goal is threefold. First we show, in silico with periodic pacing, that APD and calcium alternans develops locally in a small region before spreading to the rest of the domain and that the slope of the restitution curve for cells in the said small region is different than the restitution curve of cells which exhibit alternans at a later time. These results are in agreement with experimental data. The restitution hypothesis was derived under the assumption of periodic stimulation, when there is a dependence of the DI on the immediate preceding APD (i.e. feedback). However, under physiological conditions, the heart rate exhibits substantial variations in time, known as heart rate variability (HRV). Our second goal is to investigate the role of HRV in the alternans formation in isolated cardiac myocytes using numerical simulations of an ionic model of the cardiac action potential. We use two different pacing protocols: a periodic pacing protocol with feedback and a protocol without feedback and show that when HRV is incorporated in the periodic pacing protocol, it facilitates alternans formation in the isolated cell. Furthermore we show that the magnitude of alternans does not change significantly. In the case of the pacing protocol without feedback, alternans formation is prevented, even in the presence of HRV. Lastly, we derive a probabilistic model that incorporates HRV in a restitution curve. We show that this model conserves probability and that it has eigenvalue λ=1 for all parameters and eigenvalue λ=-1 under certain conditions. We derive a numerical scheme that conserves probability and present numerical results using a simple restitution curve.

Subjects/Keywords: action potential duration; alternans; APD; arrythemia; cardiac

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APA (6^th Edition):

McIntyre, S. (2015). Understand and analyzing APD alternans. (Doctoral Dissertation). University of Minnesota. Retrieved from http://hdl.handle.net/11299/175691

Chicago Manual of Style (16^th Edition):

McIntyre, Stephen. “Understand and analyzing APD alternans.” 2015. Doctoral Dissertation, University of Minnesota. Accessed April 22, 2021. http://hdl.handle.net/11299/175691.

MLA Handbook (7^th Edition):

McIntyre, Stephen. “Understand and analyzing APD alternans.” 2015. Web. 22 Apr 2021.

Vancouver:

McIntyre S. Understand and analyzing APD alternans. [Internet] [Doctoral dissertation]. University of Minnesota; 2015. [cited 2021 Apr 22]. Available from: http://hdl.handle.net/11299/175691.

Council of Science Editors:

McIntyre S. Understand and analyzing APD alternans. [Doctoral Dissertation]. University of Minnesota; 2015. Available from: http://hdl.handle.net/11299/175691

University of Minnesota

6. Schmidt, Megan. Utility of Monophasic Action Potentials in the Diagnosis and Treatment of Cardiac Arrhythmias.

Degree: PhD, Biomedical Engineering, 2018, University of Minnesota

URL: http://hdl.handle.net/11299/198366

► The object of this thesis was to investigate applications for monophasic action potential (MAP) recordings in the diagnosis and treatment of cardiac arrhythmias. To meet… (more)

▼ The object of this thesis was to investigate applications for monophasic action potential (MAP) recordings in the diagnosis and treatment of cardiac arrhythmias. To meet this objective, MAPs were measured in situ and in vitro, during sinus rhythm and cardiac arrhythmias. MAPs were analyzed for potential clinical applications and in novel cardiac mapping and ablation catheter concepts. MAPs are focal action potential recordings which are directly proportional to the electrical activities of cells adjacent to a contacting electrode. When sufficient force is applied between a contacting electrode and the myocardium, the cells directly beneath become mechanically depolarized; i.e. electrically inactive. As a transmembrane action potential passes through this region, a change in boundary currents between the active and inactive cells, via gap junctions, results in a waveform that is proportional to the original action potential. The Visible Heart® Apparatus provides us with the ability to study large mammalian hearts, including human, in an in vitro setting; allowing the testing of prototype catheter concepts prior to in situ or in vivo work. To validate MAPs from an in vitro working heart model a comparison study was conducted. Over the course of 2 hours in situ and 2 hours in vitro MAPs were recorded from the right atrium, left atrium, and right ventricle (endocardially and epicardially). Overall, there were no significant differences between recorded signals when compared to in situ baseline recordings. Based on these findings, systems like the Visible Heart® Apparatus can be used as a platform on which cardiac action potentials can be studied. The clinical application of MAP recordings, as they pertain to radiofrequency (RF) ablations, was also evaluated. To ensure proper lesion formation, RF ablation requires a catheter contact force (CF) of between 10-20 grams to be maintained throughout energy delivery. It was determined that MAP waveforms could only be recorded when at least 10-15 grams of CF was applied to the myocardium. In other words, the presence of MAP waveforms would indicate that sufficient CF has been applied prior to the delivery of RF energy. Additionally, MAP waveforms were found to correlate with RF lesion size. MAP amplitudes at baseline (pre-ablation) were significantly larger than amplitudes from lesions which matured to greater than 1 mm deep. MAPs were also able to distinguish between lesions between 1-2mm deep, and those deeper than 2mm. Moving forward, MAPs may be used in evaluating cardiac viability, both through recording from induced lesions, as well as in regions of scarred or ischemic myocardium.

Subjects/Keywords: ablation; cardiac; catheter; electrophysiology; monophasic action potential

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APA (6^th Edition):

Schmidt, M. (2018). Utility of Monophasic Action Potentials in the Diagnosis and Treatment of Cardiac Arrhythmias. (Doctoral Dissertation). University of Minnesota. Retrieved from http://hdl.handle.net/11299/198366

Chicago Manual of Style (16^th Edition):

Schmidt, Megan. “Utility of Monophasic Action Potentials in the Diagnosis and Treatment of Cardiac Arrhythmias.” 2018. Doctoral Dissertation, University of Minnesota. Accessed April 22, 2021. http://hdl.handle.net/11299/198366.

MLA Handbook (7^th Edition):

Schmidt, Megan. “Utility of Monophasic Action Potentials in the Diagnosis and Treatment of Cardiac Arrhythmias.” 2018. Web. 22 Apr 2021.

Vancouver:

Schmidt M. Utility of Monophasic Action Potentials in the Diagnosis and Treatment of Cardiac Arrhythmias. [Internet] [Doctoral dissertation]. University of Minnesota; 2018. [cited 2021 Apr 22]. Available from: http://hdl.handle.net/11299/198366.

Council of Science Editors:

Schmidt M. Utility of Monophasic Action Potentials in the Diagnosis and Treatment of Cardiac Arrhythmias. [Doctoral Dissertation]. University of Minnesota; 2018. Available from: http://hdl.handle.net/11299/198366

Washington State University

7. [No author]. Optical Imaging of Neural and Hemodynamic Brain Activity .

Degree: 2011, Washington State University

URL: http://hdl.handle.net/2376/2854

► Optical imaging technologies can be used to record neural and hemodynamic activity. Neural activity elicits physiological changes that alter the optical tissue properties. Specifically, changes… (more)

▼ Optical imaging technologies can be used to record neural and hemodynamic activity. Neural activity elicits physiological changes that alter the optical tissue properties. Specifically, changes in polarized light are concomitant with neural depolarization. We measured polarization changes from an isolated lobster nerve during action potential propagation using both reflected and transmitted light. In transmission mode, polarization changes were largest throughout the center of the nerve, suggesting that most of the optical signal arose from the inner nerve bundle. In reflection mode, polarization changes were largest near the edges, suggesting that most of the optical signal arose from the outer sheath. To overcome irregular cell orientation found in the brain, we measured polarization changes from a nerve tied in a knot. Our results show that neural activation produces polarization changes that can be imaged even without regular cell orientations. Neural activation expends energy resources and elicits metabolic delivery through blood vessel dilation, increasing blood flow and volume. We used spectroscopic imaging techniques combined with electrophysiological measurements to record evoked neural and hemodynamic responses from the auditory cortex of the rat. By using implantable optics, we measured responses across natural wake and sleep states, as well as responses following different amounts of sleep deprivation. During quiet sleep, evoked metabolic responses were larger compared to wake, perhaps because blood vessels were more compliant. When animals were sleep deprived, evoked hemodynamic responses were smaller following longer periods of deprivation. These results suggest that prolonged neural activity through sleep deprivation may diminish vascular compliance as indicated by the blunted vascular response. Subsequent sleep may allow vessels to relax, restoring their ability to deliver blood. These results also suggest that severe sleep deprivation or chronic sleep disturbances could push the vasculature to critical limits, leading to metabolic deficit and the potential for tissue trauma. Advisors/Committee Members: McCluskey, Matthew D (advisor).

Subjects/Keywords: Biophysics; Optics; Neurosciences; action potential; auditory cortex; birefringence; evoked response potential; NIRS; sleep

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APA (6^th Edition):

author], [. (2011). Optical Imaging of Neural and Hemodynamic Brain Activity . (Thesis). Washington State University. Retrieved from http://hdl.handle.net/2376/2854

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

author], [No. “Optical Imaging of Neural and Hemodynamic Brain Activity .” 2011. Thesis, Washington State University. Accessed April 22, 2021. http://hdl.handle.net/2376/2854.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

author], [No. “Optical Imaging of Neural and Hemodynamic Brain Activity .” 2011. Web. 22 Apr 2021.

Vancouver:

author] [. Optical Imaging of Neural and Hemodynamic Brain Activity . [Internet] [Thesis]. Washington State University; 2011. [cited 2021 Apr 22]. Available from: http://hdl.handle.net/2376/2854.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

author] [. Optical Imaging of Neural and Hemodynamic Brain Activity . [Thesis]. Washington State University; 2011. Available from: http://hdl.handle.net/2376/2854

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

IUPUI

8. Muzquiz, Maria I. Reversible Nerve Conduction Block Using Low Frequency Alternating Currents.

Degree: 2020, IUPUI

URL: http://hdl.handle.net/1805/23576

►

Indiana University-Purdue University Indianapolis (IUPUI)

This thesis describes a novel method to reversibly and safely block nerve conduction using a low frequency alternating current (LFAC)… (more)

▼

Indiana University-Purdue University Indianapolis (IUPUI)

This thesis describes a novel method to reversibly and safely block nerve conduction using a low frequency alternating current (LFAC) waveform at 1 Hz applied through a bipolar extrafascicular electrode. This work follows up on observations made on excised mammalian peripheral nerves and earthworm nerve cords. An in-situ electrophysiology setup was used to assess the LFAC waveform on propagating action potentials (APs) within the cervical vagus nerve in anaesthetized Sprague-Dawley rats (n = 12). Two sets of bipolar cuff or hook electrodes were applied unilaterally to the cervical vagus nerve, which was crushed rostral to the electrodes to exclude reflex effects on the animal. Pulse stimulation was applied to the rostral electrode, while the LFAC conditioning waveform was applied to the caudal electrode. The efferent volley, if unblocked, elicits acute bradycardia and hypotension. The degree of block of the vagal stimulation induced bradycardia was used as a biomarker. Block was assessed by the ability to reduce the bradycardic drive by monitoring the heart rate (HR) and blood pressure (BP) during LFAC alone, LFAC with vagal stimulation, and vagal stimulation alone. LFAC applied via a hook electrode (n = 7) achieved 86.6 +/- 11% block at current levels 95 +/- 38 uAp (current to peak). When applied via a cuff electrode (n = 5) 85.3 +/- 4.60% block was achieved using current levels of 110+/-65 uAp. Furthermore, LFAC was explored on larger vagal afferent fibers in larger human sized nerve bundles projecting to effects mediated by a reflex. The effectiveness of LFAC was assessed in an in-situ electrophysiological setup on the left cervical vagus in anaesthetized domestic swine (n = 5). Two bipolar cuff electrodes were applied unilaterally to the cervical vagus nerve, which was crushed caudal to the electrodes to eliminate cardiac effects. A tripolar extrafascicular cuff electrode was placed most rostral on the nerve for recording of propagating APs induced by electrical stimulation and blocked via the LFAC waveform. Standard pulse stimulation was applied to the left cervical vagus to induce the Hering-Breuer reflex. If unblocked, the activation of the Hering-Breuer reflex would cause breathing to slow down and potentially cease. Block was quantified by the ability to reduce the effect of the Hering-Breuer reflex by monitoring the breathing rate during LFAC alone, LFAC and vagal stimulation, and vagal stimulation alone. LFAC achieved 87.2 +/- 8.8% (n = 5) block at current levels of 0.8 +/- 0.3 mAp. Compound nerve action potentials (CNAP) were monitored directly. They show changes in nerve activity during LFAC, which manifests itself as the slowing and amplitude reduction of components of the CNAPs. Since the waveform is balanced, all forward reactions are reversed, leading to a blocking method that is similar in nature to DC block without the potential issues of toxic byproduct production. These results suggest that LFAC can achieve a high degree of nerve…

Advisors/Committee Members: Yoshida, Ken, Schild, John, Berbari, Ed.

Subjects/Keywords: Vagal Nerve Stimulation; Nerve Block; Conduction Block; Reversible; Electrodes; Biomarker; action potential; Compound Neural Action Potential; Vagus Nerve

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APA (6^th Edition):

Muzquiz, M. I. (2020). Reversible Nerve Conduction Block Using Low Frequency Alternating Currents. (Thesis). IUPUI. Retrieved from http://hdl.handle.net/1805/23576

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Muzquiz, Maria I. “Reversible Nerve Conduction Block Using Low Frequency Alternating Currents.” 2020. Thesis, IUPUI. Accessed April 22, 2021. http://hdl.handle.net/1805/23576.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Muzquiz, Maria I. “Reversible Nerve Conduction Block Using Low Frequency Alternating Currents.” 2020. Web. 22 Apr 2021.

Vancouver:

Muzquiz MI. Reversible Nerve Conduction Block Using Low Frequency Alternating Currents. [Internet] [Thesis]. IUPUI; 2020. [cited 2021 Apr 22]. Available from: http://hdl.handle.net/1805/23576.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Muzquiz MI. Reversible Nerve Conduction Block Using Low Frequency Alternating Currents. [Thesis]. IUPUI; 2020. Available from: http://hdl.handle.net/1805/23576

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

RMIT University

9. Hendrickx, A. Substantiating displacement.

Degree: 2013, RMIT University

URL: http://researchbank.rmit.edu.au/view/rmit:160413

► The Phd by project â€˜Substantiating displacementâ€™ looks at a generic topic through a specific lens: it looks at architectureâ€™s potential to trigger physical en mental… (more)

Subjects/Keywords: Fields of Research; Architecture; Spatial Artistic Practice; Displacement; Action Potential

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APA (6^th Edition):

Hendrickx, A. (2013). Substantiating displacement. (Thesis). RMIT University. Retrieved from http://researchbank.rmit.edu.au/view/rmit:160413

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hendrickx, A. “Substantiating displacement.” 2013. Thesis, RMIT University. Accessed April 22, 2021. http://researchbank.rmit.edu.au/view/rmit:160413.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hendrickx, A. “Substantiating displacement.” 2013. Web. 22 Apr 2021.

Vancouver:

Hendrickx A. Substantiating displacement. [Internet] [Thesis]. RMIT University; 2013. [cited 2021 Apr 22]. Available from: http://researchbank.rmit.edu.au/view/rmit:160413.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hendrickx A. Substantiating displacement. [Thesis]. RMIT University; 2013. Available from: http://researchbank.rmit.edu.au/view/rmit:160413

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

10. Chen, Jing-yuan. Design and Implementation of a Microcontroller-based Axon Emulator Circuit.

Degree: Master, Electrical Engineering, 2012, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0815112-164250

► In recent years, there has been significant research and development in the area of advanced circuits and systems for the recording of the electroneurogram (ENG)… (more)

Subjects/Keywords: Peripheral nerve; artificial nerve; microcontroller; action potential; SFAP; CAP

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APA (6^th Edition):

Chen, J. (2012). Design and Implementation of a Microcontroller-based Axon Emulator Circuit. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0815112-164250

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chen, Jing-yuan. “Design and Implementation of a Microcontroller-based Axon Emulator Circuit.” 2012. Thesis, NSYSU. Accessed April 22, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0815112-164250.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chen, Jing-yuan. “Design and Implementation of a Microcontroller-based Axon Emulator Circuit.” 2012. Web. 22 Apr 2021.

Vancouver:

Chen J. Design and Implementation of a Microcontroller-based Axon Emulator Circuit. [Internet] [Thesis]. NSYSU; 2012. [cited 2021 Apr 22]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0815112-164250.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chen J. Design and Implementation of a Microcontroller-based Axon Emulator Circuit. [Thesis]. NSYSU; 2012. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0815112-164250

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of California – Riverside

11. Islam, Md Shahidul. Optical Coherence Tomography for Structural Neuroimaging and Non-Contact Recording of Functionally Stimulated Neural Activity.

Degree: Bioengineering, 2013, University of California – Riverside

URL: http://www.escholarship.org/uc/item/5015w0kp

► Nerve activity in a biological neural network is mostly characterized by generation and propagation of impulses through the nerves. These impulses, known as action potentials,… (more)

▼ Nerve activity in a biological neural network is mostly characterized by generation and propagation of impulses through the nerves. These impulses, known as action potentials, are generated when the nerves are excited by a stimulus either as an external input or as a means of internal communication between nerves. This project is aimed to develop an optical imaging based minimally invasive technique for neural recording. Existing technologies largely limit the analysis of neuronal processing to a single or small cluster of neurons using different varieties of electrodes or the introduction of exogenous contrast agents and most of these techniques are invasive in some ways. Nerves undergo rapid transient thickness changes during propagation of action potentials. These activity associated structural changes are usually in the order of nanometers which is well beyond the usual limit of resolution of most common imaging technologies, including optical coherence tomography (OCT). However, recent advances in phase-resolved OCT (pr-OCT), a specific modality of OCT, have enabled the measurement of subnanometer changes in optical path length. This study demonstrates pr-OCT's capability to detect and measure rapid transient thickness changes in nerves during activity. Optically detected changes in nerve fiber thickness have timing and duration similar to the propagating electrical signal recorded in electrophysiology. Averaging of 8-10 impulses improves the SNR of detected optical signal. However, most of the results demonstrated here are single shot detections. Since OCT collects data from every depth points within a single A-line simultaneously, the changes in phase at every depth location are examined. Results demonstrate that these transient changes are present at different depths and this allows representing activity as a map of thickness changes. A custom-built cold block system has been used for switchable control of activation and deactivation of action potential propagation through the Limulus nerve. Optical recording has been compared with simultaneous electrical recording at every stages of cold block operation: activated nerve before deactivation, nerve after deactivation and nerve after reactivation. Hopefully, this study will serve as the basic ground work for future experiments and will have an overall significant impact on functional neuroimaging.

Subjects/Keywords: Biomedical engineering; Action Potential; Electrophysiology; Limulus; Neuronal Swelling; OCT; Optic Nerve

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APA (6^th Edition):

Islam, M. S. (2013). Optical Coherence Tomography for Structural Neuroimaging and Non-Contact Recording of Functionally Stimulated Neural Activity. (Thesis). University of California – Riverside. Retrieved from http://www.escholarship.org/uc/item/5015w0kp

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Islam, Md Shahidul. “Optical Coherence Tomography for Structural Neuroimaging and Non-Contact Recording of Functionally Stimulated Neural Activity.” 2013. Thesis, University of California – Riverside. Accessed April 22, 2021. http://www.escholarship.org/uc/item/5015w0kp.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Islam, Md Shahidul. “Optical Coherence Tomography for Structural Neuroimaging and Non-Contact Recording of Functionally Stimulated Neural Activity.” 2013. Web. 22 Apr 2021.

Vancouver:

Islam MS. Optical Coherence Tomography for Structural Neuroimaging and Non-Contact Recording of Functionally Stimulated Neural Activity. [Internet] [Thesis]. University of California – Riverside; 2013. [cited 2021 Apr 22]. Available from: http://www.escholarship.org/uc/item/5015w0kp.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Islam MS. Optical Coherence Tomography for Structural Neuroimaging and Non-Contact Recording of Functionally Stimulated Neural Activity. [Thesis]. University of California – Riverside; 2013. Available from: http://www.escholarship.org/uc/item/5015w0kp

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Tampere University

12. Prajapati, Chandra Krishna. Study of Hypertrophic Cardiomyopathy Using Human Induced Pluripotent Stem Cell Derived Cardiomyocytes .

Degree: 2018, Tampere University

URL: https://trepo.tuni.fi/handle/10024/104106

► Ihmisen indusoidut kantasolut (hiPS-solut) ja niistä erilaistetut sydänlihassolut (hiPS-CM:t) ovat mullistaneet in vitro tautimallinnuksen. hiPS-solut sisältävät saman geneettisen informaation kuin se henkilö, josta solut ovat… (more)

▼ Ihmisen indusoidut kantasolut (hiPS-solut) ja niistä erilaistetut sydänlihassolut (hiPS-CM:t) ovat mullistaneet in vitro tautimallinnuksen. hiPS-solut sisältävät saman geneettisen informaation kuin se henkilö, josta solut ovat peräisin. Tämän ainutlaatuisen ominaisuutensa ansiosta hiPS-solut tarjoavat työkalun, jonka avulla voidaan tutkia perinnöllisiä sairauksia, seuloa uusia lääkkeitä, sekä tarjota yksilöllistä terveydenhoitoa tulevaisuudessa. Hypertrofinen eli paksuseinäinen kardiomyopatia (HCM) on yksi yleisimmistä perinnöllisistä sydänsairauksista, prevalenssin ollessa 1:500. HCM:n aiheuttamat mutaatiot sijaitsevat pääosin sydämen sarkomeereissä (~90% lihaksen supistumiseen liittyvissä proteiineissa). Yleisimmät Suomessa esiintyvät HCM-mutaatiot sijaitsevat alfa-tropomyosiinia (TPM1-Asp175Asn) ja myosiinia sitovaa proteiinia (MYBPC3-Gln1061X) koodaavissa geeneissä. Nämä valtamutaatiot kattavat yhdessä noin 18% suomalaisista HCM-tapauksista. Kudostasolla HCM aiheuttaa sydänlihassolujen epäjärjestymistä, sydänlihaskudoksen fibroosia, sekä paksuuntumaa (15-50mm) kammioiden väliseen seinämään tai muihin kammioiden seinämiin. Kliiniset oireet vaihtelevat, mutta äkkikuolema voi olla HCM:n ensimmäinen ja samalla ainoa oire nuorilla aikuisilla, erityisesti urheilijoilla. HCM-potilaiden äkkikuolemiin johtavien vakavien rytmihäiriöiden mekanismia ei vielä tunneta. Tämän vuoksi HCM:n patofysiologiset mekanismit tulisi selvittää, jotta tautia voitaisiin ymmärtää paremmin, ja jotta siihen voitaisiin kehittää uusia hoitomuotoja. Tämän väitöskirjan tarkoituksena oli tutkia joko TPM1-Asp175Asn tai MYBPC3-Gln1061X mutaatioita sisältävien potilasspesifisten hiPS-CM:jen elektrofysiologisia ominaisuuksia. Ensimmäisenä tavoitteena oli luoda solumallit HCM:n laboratorio-tutkimusta varten iPS-CM:jen avulla. Nämä HCM-spesifiset hiPS-CM:t ilmensivät HCM:n löydöksiä yksisolutasolla. Toisena tavoitteena oli tutkia adrenaliinin eri konsentraatioiden vaikutuksia aktiopotentiaalin parametreihin ja rytmihäiriöiden esiintyvyyteen kehitetyissä HCM-solumalleissa. Myös rytmihäiriön estolääkityksenä käytetyn bisoprololin tehokkuutta tutkittiin HCM-solumalleissa. Näiden lisäksi tutkittiin myös sykkeen ja repolarisaation vaihtelevuutta. Kolmantena tavoitteena oli tutkia kahden toisistaan riippuvaisen tapahtuman, eli solukalvon sähköpotentiaalin ja kalsium-aineenvaihdunnan, yhteyttä sydänlihassoluissa mittaamalla kumpaakin parametria samanaikaisesti. Johtopäätöksenä voidaan todeta, että hiPS-CM:t tarjoavat luotettavan solumallin perinnöllisten sydänsairauksien tutkimusta varten. Tässä työssä käytetty koeasetelma on käyttökelpoinen ja hyödyllinen myös muita sydänsairauksia tutkittaessa. Tämän lisäksi Vm ja CaT –parametrien samanaikainen mittaaminen auttaa niiden keskinäisen riippuvuuden ymmärtämisessä, ja menetelmää voidaan hyödyntää myös rytmihäiriöihin johtavien mekanismien selvittämisessä.; The human induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) technology remarkably improves in vitro disease modelling, which retain the…

Subjects/Keywords: Hypertrophic cardiomyopathy ; hiPSC-CM ; action potential ; calcium transient ; arrhythmia

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APA (6^th Edition):

Prajapati, C. K. (2018). Study of Hypertrophic Cardiomyopathy Using Human Induced Pluripotent Stem Cell Derived Cardiomyocytes . (Doctoral Dissertation). Tampere University. Retrieved from https://trepo.tuni.fi/handle/10024/104106

Chicago Manual of Style (16^th Edition):

Prajapati, Chandra Krishna. “Study of Hypertrophic Cardiomyopathy Using Human Induced Pluripotent Stem Cell Derived Cardiomyocytes .” 2018. Doctoral Dissertation, Tampere University. Accessed April 22, 2021. https://trepo.tuni.fi/handle/10024/104106.

MLA Handbook (7^th Edition):

Prajapati, Chandra Krishna. “Study of Hypertrophic Cardiomyopathy Using Human Induced Pluripotent Stem Cell Derived Cardiomyocytes .” 2018. Web. 22 Apr 2021.

Vancouver:

Prajapati CK. Study of Hypertrophic Cardiomyopathy Using Human Induced Pluripotent Stem Cell Derived Cardiomyocytes . [Internet] [Doctoral dissertation]. Tampere University; 2018. [cited 2021 Apr 22]. Available from: https://trepo.tuni.fi/handle/10024/104106.

Council of Science Editors:

Prajapati CK. Study of Hypertrophic Cardiomyopathy Using Human Induced Pluripotent Stem Cell Derived Cardiomyocytes . [Doctoral Dissertation]. Tampere University; 2018. Available from: https://trepo.tuni.fi/handle/10024/104106

Stellenbosch University

13. Wessels, Annemie. The development and empirical evaluation of a competency model of trainer-instructor performance : an elaboration on a partial competency model of trainer-instructor performance.

Degree: MCom, Industrial Psychology, 2019, Stellenbosch University

URL: http://hdl.handle.net/10019.1/105763

► ENGLISH SUMMARY : As a result of apartheid, South Africa is currently faced with a myriad of socio-economic challenges. These socio-economic challenges include, but are… (more)

▼ ENGLISH SUMMARY : As a result of apartheid, South Africa is currently faced with a myriad of socio-economic challenges. These socio-economic challenges include, but are not limited to, poor education, national skill shortages, unemployment, inequality in the workplace, poor economic and development growth, poverty, dependence on social assistance grants, poor implementation and execution of legislation, and weak global competitiveness. These socio-economic challenges and problems are causally related and thus influence each other. They also affect the productivity of South Africa’s workforce. The current study argued that the root of South Africa’s current high poverty status is due to poor education. Poor education results in fewer people obtaining critical skills and qualifications, which further results in fewer people being employable. With fewer people being employable, the unemployment rate increases and as a result the poverty rate also increases. Affirmative development can be viewed as one possible solution to the current challenges faced by South Africa. Affirmative development programmes should be developed, implemented, and supported by government as well as the private sector. As an organisational unit that is responsible for the flow of workers into, through and out of the organisation as well as the maintenance of the workforce Human Resource Management should design and implement such training and development programmes. The objective of affirmative development is to improve the employability of previously disadvantaged individuals who have already entered the labour market. This can be done through developing their job competency potential and thereby increasing their competence on the job competencies in order to enhance their productivity. This can then also improve the overall performance of the organisation and ultimately reduce the high poverty levels and crime rate in South Africa. The primary objective of this research study was to elaborate on the existing partial Van der Westhuizen (2015) affirmative development trainer-instructor performance competency model in an attempt to better understand the role that the trainer-instructor plays in the learning performance of affirmative development trainees. The purpose of the research was to enhance the learning competency potential and learning competencies of these affirmative development trainees by enhancing the performance of the trainer-instructor. The final reduced Wessels-Van der Westhuizen trainer-instructor competency model, consisted of (a) five trainer-instructor latent variables as proposed by Van der Westhuizen (2015), namely, learning motivation (learning competency potential latent variable); inspiring professional vision (trainer-instructor outcome latent variable), learning climate and structure in the learning material (training situational latent variables), as well as facilitating clarity and understanding (trainer-instructor competency latent variable); and (b) five newly introduced … Advisors/Committee Members: Theron, C. C., Stellenbosch University. Faculty of Economic and Management Sciences. Dept. of Industrial Psychology..

Subjects/Keywords: Learning potential, trainer-instructor, structural model, affirmative action;

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APA (6^th Edition):

Wessels, A. (2019). The development and empirical evaluation of a competency model of trainer-instructor performance : an elaboration on a partial competency model of trainer-instructor performance. (Thesis). Stellenbosch University. Retrieved from http://hdl.handle.net/10019.1/105763

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wessels, Annemie. “The development and empirical evaluation of a competency model of trainer-instructor performance : an elaboration on a partial competency model of trainer-instructor performance.” 2019. Thesis, Stellenbosch University. Accessed April 22, 2021. http://hdl.handle.net/10019.1/105763.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wessels, Annemie. “The development and empirical evaluation of a competency model of trainer-instructor performance : an elaboration on a partial competency model of trainer-instructor performance.” 2019. Web. 22 Apr 2021.

Vancouver:

Wessels A. The development and empirical evaluation of a competency model of trainer-instructor performance : an elaboration on a partial competency model of trainer-instructor performance. [Internet] [Thesis]. Stellenbosch University; 2019. [cited 2021 Apr 22]. Available from: http://hdl.handle.net/10019.1/105763.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wessels A. The development and empirical evaluation of a competency model of trainer-instructor performance : an elaboration on a partial competency model of trainer-instructor performance. [Thesis]. Stellenbosch University; 2019. Available from: http://hdl.handle.net/10019.1/105763

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade Nova

14. Baião, Pedro de Abreu Avó. Nanostructuring silicon probes via electrodeposition: characterization of electrode coatings for acute in vivo neural recordings.

Degree: 2015, Universidade Nova

URL: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/14666

► Understanding how the brain works will require tools capable of measuring neuron elec-trical activity at a network scale. However, considerable progress is still necessary to… (more)

Subjects/Keywords: Neurons; Microelectrodes; Electrodeposition; Impedance; Cyclic voltammetry; Action potential

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APA (6^th Edition):

Baião, P. d. A. A. (2015). Nanostructuring silicon probes via electrodeposition: characterization of electrode coatings for acute in vivo neural recordings. (Thesis). Universidade Nova. Retrieved from http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/14666

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Baião, Pedro de Abreu Avó. “Nanostructuring silicon probes via electrodeposition: characterization of electrode coatings for acute in vivo neural recordings.” 2015. Thesis, Universidade Nova. Accessed April 22, 2021. http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/14666.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Baião, Pedro de Abreu Avó. “Nanostructuring silicon probes via electrodeposition: characterization of electrode coatings for acute in vivo neural recordings.” 2015. Web. 22 Apr 2021.

Vancouver:

Baião PdAA. Nanostructuring silicon probes via electrodeposition: characterization of electrode coatings for acute in vivo neural recordings. [Internet] [Thesis]. Universidade Nova; 2015. [cited 2021 Apr 22]. Available from: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/14666.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Baião PdAA. Nanostructuring silicon probes via electrodeposition: characterization of electrode coatings for acute in vivo neural recordings. [Thesis]. Universidade Nova; 2015. Available from: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/14666

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Manchester

15. Kirkwood, Graeme. A translational approach to dyssynchrony.

Degree: PhD, 2014, University of Manchester

URL: https://www.research.manchester.ac.uk/portal/en/theses/a-translational-approach-to-dyssynchrony(d5b11102-590e-46c7-8c5f-1fb248c0e84a).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.677728

► Normal cardiac function is dependent on a healthy conduction system to maintain coordinated and synchronised activity. In the presence of heart failure, dyssynchronous ventricular activation… (more)

▼ Normal cardiac function is dependent on a healthy conduction system to maintain coordinated and synchronised activity. In the presence of heart failure, dyssynchronous ventricular activation due to left bundle branch block or right ventricular pacing can result in worsening symptoms and increased mortality; cardiac resynchronisation therapy in the form of biventricular pacing has therefore become an established and effective treatment. However, it also appears that right ventricular pacing can be a cause of heart failure in some individuals, even when there is no evidence of associated pre-existing cardiac disease. A better understanding of the processes leading to dyssynchrony-induced cardiomyopathy will allow better identification and treatment of patients who are at risk, and will contribute to our knowledge about heart failure in general. This PhD adopted a translational approach to cardiac dyssynchrony, by developing a novel model of atrial-synchronous ventricular pacing in adult Welsh Mountain sheep. The right ventricle was paced from the apex continuously for 3 months at a rate that was determined by the intrinsic atrial rate; this allowed the ventricular activation pattern to be altered without changing the heart rate. In parallel, a previously-developed model of rapid ventricular pacing was studied. In this model, the heart was paced continuously at a fixed rate of 210 bpm, which led to the development of symptomatic heart failure. In vivo parameters were characterised using standard clinical techniques of electrocardiography and echocardiography. Autonomic nervous system activity was investigated by examining the heart rate responses to pharmacological blockade using atropine and propranolol, and to beta-adrenergic stimulation using dobutamine. Heart rate variability was analysed in the time and frequency domains. In vitro, patch clamping studies were performed on ventricular myocytes isolated through enzymatic digestion from the interventricular septum and left ventricular free wall. Using the perforated patch current clamp technique at 37 C, action potential duration was measured and the associated triggered calcium transient was analysed using the calcium-sensitive fluorescent indicator Fura-2AM.Heart failure was associated with in vivo evidence of autonomic dysfunction, including a 38 % increase in the resting heart rate, blunting of the heart rate response to dobutamine, and almost complete loss of vagal tonic heart rate control. This pattern was not present in dyssynchrony. At a cellular level, normal sheep had heterogeneity of action potential duration, which was longer in the septum than the free wall. Heart failure disrupted this pattern, and was also associated with approximately a 40 % reduction in the magnitude of the calcium transient in both the septum and the free wall. Dyssynchrony was associated with a similar reduction in the calcium transient, but this was isolated to the free wall. RV apical pacing therefore induced a phenotype that resembled a localised cardiomyopathy, but without the…

Subjects/Keywords: 616.1; Pacemaker; Dyssynchrony; Heart failure; Cardiac; Cellular; Action potential

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APA (6^th Edition):

Kirkwood, G. (2014). A translational approach to dyssynchrony. (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/a-translational-approach-to-dyssynchrony(d5b11102-590e-46c7-8c5f-1fb248c0e84a).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.677728

Chicago Manual of Style (16^th Edition):

Kirkwood, Graeme. “A translational approach to dyssynchrony.” 2014. Doctoral Dissertation, University of Manchester. Accessed April 22, 2021. https://www.research.manchester.ac.uk/portal/en/theses/a-translational-approach-to-dyssynchrony(d5b11102-590e-46c7-8c5f-1fb248c0e84a).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.677728.

MLA Handbook (7^th Edition):

Kirkwood, Graeme. “A translational approach to dyssynchrony.” 2014. Web. 22 Apr 2021.

Vancouver:

Kirkwood G. A translational approach to dyssynchrony. [Internet] [Doctoral dissertation]. University of Manchester; 2014. [cited 2021 Apr 22]. Available from: https://www.research.manchester.ac.uk/portal/en/theses/a-translational-approach-to-dyssynchrony(d5b11102-590e-46c7-8c5f-1fb248c0e84a).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.677728.

Council of Science Editors:

Kirkwood G. A translational approach to dyssynchrony. [Doctoral Dissertation]. University of Manchester; 2014. Available from: https://www.research.manchester.ac.uk/portal/en/theses/a-translational-approach-to-dyssynchrony(d5b11102-590e-46c7-8c5f-1fb248c0e84a).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.677728

New Jersey Institute of Technology

16. Korgaonkar, Akshata Anand. EMG-based determination of upper extremity virtual trajectory.

Degree: MSin Biomedical Engineering - (M.S.), Biomedical Engineering, 2011, New Jersey Institute of Technology

URL: https://digitalcommons.njit.edu/theses/81

► Movement and position of the limbs of the human body are controlled by the interaction between the muscle and the peripheral and central nervous… (more)

Subjects/Keywords: Virtual trajectory; Electromyography; Action potential; Biomedical Engineering and Bioengineering

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APA (6^th Edition):

Korgaonkar, A. A. (2011). EMG-based determination of upper extremity virtual trajectory. (Thesis). New Jersey Institute of Technology. Retrieved from https://digitalcommons.njit.edu/theses/81

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Korgaonkar, Akshata Anand. “EMG-based determination of upper extremity virtual trajectory.” 2011. Thesis, New Jersey Institute of Technology. Accessed April 22, 2021. https://digitalcommons.njit.edu/theses/81.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Korgaonkar, Akshata Anand. “EMG-based determination of upper extremity virtual trajectory.” 2011. Web. 22 Apr 2021.

Vancouver:

Korgaonkar AA. EMG-based determination of upper extremity virtual trajectory. [Internet] [Thesis]. New Jersey Institute of Technology; 2011. [cited 2021 Apr 22]. Available from: https://digitalcommons.njit.edu/theses/81.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Korgaonkar AA. EMG-based determination of upper extremity virtual trajectory. [Thesis]. New Jersey Institute of Technology; 2011. Available from: https://digitalcommons.njit.edu/theses/81

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Delft University of Technology

17. Heijmans, Itai (author). A Trade-Off Analysis Between Random Noise Attenuation and Muscle State Preservation: A Simulation Study on Stretch Reflex Responses.

Degree: 2019, Delft University of Technology

URL: http://resolver.tudelft.nl/uuid:72ec6372-48fd-4b2b-ae6e-8c827f7c606e

► The surface electromyographic (sEMG) signals that originate from skeletal muscle electrical activity, are used clinically and experimentally to determine muscular behaviour, e.g. amplitude, area under… (more)

▼ The surface electromyographic (sEMG) signals that originate from skeletal muscle electrical activity, are used clinically and experimentally to determine muscular behaviour, e.g. amplitude, area under the curve and onset of activity. Surface EMG signals are inevitably contaminated by noise and artefacts from the site between the skin and electrodes, non-target muscles and recording hardware. After recording, signal processing methods like filtering, are used in an attempt to determine the underlying active state of the muscle, portrayed by the motoneuron pool firing. As EMG is in fact a deformed representation of the actual muscle activity, processing is used to extract a more veracious description of the active muscle states. This study investigated the effects of random noise - which in practice resembles transducer noise -, and filtering on the simulation accuracy of short and long latency muscle stretch responses, extracted from simulated EMG signals. To obtain the deviation from the noiseless signals, a fiber potential model was developed to simulate the EMG surface potentials that used an existing motoneuron pool firing model by Schuurmans et al. 2009. The resulting EMGs were the muscle responses to stretch perturbations at different velocities and amplitudes combinations (1.5, 2, 3, 5 rad/s and 0.06, 0.10, 0.14 rad). Consecutively, the EMG signals were contaminated with different noise intensities (SNR: -1, 2, 5, 7, 9 dB) and then filtered with a \nth{3} order Butterworth low-pass filter, with cut-off frequencies between [1-200Hz]. Finally, the short- and long latency stretch responses areas were calculated and compared between the filtered noiseless and filtered noisy EMG signals, by calculating the difference between the values as a fraction of the value from the noiseless simulated signal. It was found that a signal-to-noise ratio of at least 5 dB with a 85Hz cut-off low-pass filter was necessary to keep the error below 10% maintaining M1 and M2 characteristics. It was also seen that M1 was more affected than M2 under the same amount of contamination, suggesting different spectral frequency contents between the stretch responses, and different underlying neuronal firing behaviour. The described signal-to-noise ratio thresholds and proposed cut-off frequencies resulting in acceptable signal error, can be used as a reference on accuracy of latency response simulations. The error courses provide information about the way error and signal are attenuated or preserved. Besides, the differences in error course comparing the two latency responses provides an insight into the difference in behaviour between the underlying reflex mechanisms. Apart from the findings the combination of adapted and developed model can be used in future research where noise-free surface potentials are required, and can be further developed to produce veracious EMG signals. Advisors/Committee Members: Schouten, Alfred (mentor), Rodriguez Hernandez, Karen (graduation committee), Delft University of Technology (degree granting institution).

Subjects/Keywords: EMG; Motor Unit Action Potential modelling; Filtering; Noise

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APA (6^th Edition):

Heijmans, I. (. (2019). A Trade-Off Analysis Between Random Noise Attenuation and Muscle State Preservation: A Simulation Study on Stretch Reflex Responses. (Masters Thesis). Delft University of Technology. Retrieved from http://resolver.tudelft.nl/uuid:72ec6372-48fd-4b2b-ae6e-8c827f7c606e

Chicago Manual of Style (16^th Edition):

Heijmans, Itai (author). “A Trade-Off Analysis Between Random Noise Attenuation and Muscle State Preservation: A Simulation Study on Stretch Reflex Responses.” 2019. Masters Thesis, Delft University of Technology. Accessed April 22, 2021. http://resolver.tudelft.nl/uuid:72ec6372-48fd-4b2b-ae6e-8c827f7c606e.

MLA Handbook (7^th Edition):

Heijmans, Itai (author). “A Trade-Off Analysis Between Random Noise Attenuation and Muscle State Preservation: A Simulation Study on Stretch Reflex Responses.” 2019. Web. 22 Apr 2021.

Vancouver:

Heijmans I(. A Trade-Off Analysis Between Random Noise Attenuation and Muscle State Preservation: A Simulation Study on Stretch Reflex Responses. [Internet] [Masters thesis]. Delft University of Technology; 2019. [cited 2021 Apr 22]. Available from: http://resolver.tudelft.nl/uuid:72ec6372-48fd-4b2b-ae6e-8c827f7c606e.

Council of Science Editors:

Heijmans I(. A Trade-Off Analysis Between Random Noise Attenuation and Muscle State Preservation: A Simulation Study on Stretch Reflex Responses. [Masters Thesis]. Delft University of Technology; 2019. Available from: http://resolver.tudelft.nl/uuid:72ec6372-48fd-4b2b-ae6e-8c827f7c606e

University of Minnesota

18. Johnson, Christopher. The anti-arrhythmic effects of constant diastolic interval pacing in a numerical model of a canine cardiac ventricular fiber.

Degree: MS, Biomedical Engineering, 2016, University of Minnesota

URL: http://hdl.handle.net/11299/182128

► Beat to beat changes in action potential duration (APD) are known as alternans. Alternans are precursors for cardiac arrhythmias that may lead to heart failure… (more)

Subjects/Keywords: Action Potential Duration; Alternans; Anti-arrhythmic; Diastolic Interval Pacing; Numerical Modeling

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APA (6^th Edition):

Johnson, C. (2016). The anti-arrhythmic effects of constant diastolic interval pacing in a numerical model of a canine cardiac ventricular fiber. (Masters Thesis). University of Minnesota. Retrieved from http://hdl.handle.net/11299/182128

Chicago Manual of Style (16^th Edition):

Johnson, Christopher. “The anti-arrhythmic effects of constant diastolic interval pacing in a numerical model of a canine cardiac ventricular fiber.” 2016. Masters Thesis, University of Minnesota. Accessed April 22, 2021. http://hdl.handle.net/11299/182128.

MLA Handbook (7^th Edition):

Johnson, Christopher. “The anti-arrhythmic effects of constant diastolic interval pacing in a numerical model of a canine cardiac ventricular fiber.” 2016. Web. 22 Apr 2021.

Vancouver:

Johnson C. The anti-arrhythmic effects of constant diastolic interval pacing in a numerical model of a canine cardiac ventricular fiber. [Internet] [Masters thesis]. University of Minnesota; 2016. [cited 2021 Apr 22]. Available from: http://hdl.handle.net/11299/182128.

Council of Science Editors:

Johnson C. The anti-arrhythmic effects of constant diastolic interval pacing in a numerical model of a canine cardiac ventricular fiber. [Masters Thesis]. University of Minnesota; 2016. Available from: http://hdl.handle.net/11299/182128

University of Kansas

19. Miller, Jonathan Daniel. EXAMINATION OF MUSCLE QUALITY AND MOTOR UNIT BEHAVIOR OF THE FIRST DORSAL INTEROSSEOUS OF NORMAL AND OVERWEIGHT CHILDREN.

Degree: M.S.Ed., Health, Sport and Exercise Sciences, 2017, University of Kansas

URL: http://hdl.handle.net/1808/25951

► It is unknown whether differences in muscle quality or motor unit (MU) behavior exist between normal weight (NW) and overweight (OW) children Purpose: Therefore, the… (more)

▼ It is unknown whether differences in muscle quality or motor unit (MU) behavior exist between normal weight (NW) and overweight (OW) children Purpose: Therefore, the purposes of this study were to examine potential differences in the first dorsal interosseous (FDI) between NW and OW for peak maximal voluntary contraction force (MVC force), muscle cross-sectional area (CSA), subcutaneous fat (sFAT), and echo intensity (EI), as well as parameters of motor unit behavior, specifically motor unit action potential size (MUAPSIZE) vs. recruitment threshold (RT), mean firing rate (MFR) vs. MUAPSIZE, and MFR vs. RT relationships, as well as EMG amplitude (EMGRMS[normalized as %max]). Methods: Anthropometric assessments were taken for body mass, BMI, and percent body fat (%BF). Ultrasonography scans of the FDI were completed in order to determine the muscle CSA, sFAT, and EI. MU behavior will be assessed during isometric muscle actions of the FDI at 20% and 50% MVC by the decomposition of the EMG signal from the surface of the skin. Results: OW was significantly greater than NW for mass (P < 0.001, NW = 30.96 ± 3.68 kg, OW = 41.37 ± 7.31 kg), BMI (P < 0.001, NW = 15.96 ± 0.94 kg/m2, OW = 21.22 ± 2.19 kg/m2), %BF (P < 0.001, NW = 17.01 ± 3.25%, OW = 31.01 ± 4.97%), sFAT (P < 0.001, NW = 2.19 ± 0.60 mm, OW = 3.71 ± 0.97 mm), and EI (P = 0.002, NW = 47.99 ± 6.01 AU, OW = 58.90 ± 10.63 AU). There were no differences between groups for CSA (P = 0.688, NW = 1.138 ± 0.146 cm2, OW = 1.162 ± 0.156 cm2), MVC force (P = 0.790, NW = 14.81 ± 3.49 N, OW = 14.43 ± 3.87 N) or MVC force/CSA (P = 0.697, NW = 13.00 ± 2.84 N/cm2, OW = 12.52 ± 3.60 N/cm2). However, NW had significantly greater lean CSA (CSA/EI) than OW (P = 0.040, NW = 0.024 ± 0.004 cm2/AU, OW = 0.020 ± .005 cm2/AU). For the MUAPSIZE vs. RT relationships, A terms were greater for NW (0.185 ± 0.12 mV) than OW (0.091 ± 0.05 mV) (P = 0.002), and for the MFR vs. MUAPSIZE relationships the B terms were less negative (P = 0.039) for the NW (-1.98 ± 1.36 pps/mV) than OW (-2.79 ± 1.46 pps/mV). There were no differences between groups for the slopes and y-intercepts from the MFR vs. RT relationships or for EMGRMS, however, slopes for the 50% MVC were less negative (-0.646 ± 0.18 pps/%MVC) than the slopes for the 20% MVC (-1.46 ± 0.64 pps/%MVC) and EMGRMS was greater for the 50% MVC (86.23 ± 37.7%) than the 20% MVC (32.27 ± 12.4%). Discussion: It is plausible that alterations in muscle architecture and/or stiffness as a result of greater intramuscular fat allowed the OW group to produce similar isometric MVC strength to the NW while possessing less lean CSA. This is supported by the finding that NW showed greater MUAPSIZES than OW at similar RTs and MFRs, which can be an indication of greater motor unit and muscle fiber size. The MFR vs. RT relationships for both groups agreed with the onion skin scheme, and were similar to what has previously been reported in adults, however, EMGRMS for the 50% MVC was greater for children in the current study than what has been previously reported for… Advisors/Committee Members: Herda, Trent J (advisor), Fry, Andrew C (cmtemember), Gallagher, Philip (cmtemember).

Subjects/Keywords: Physiology; action potential; children; echo intensity; firing rate; Motor unit

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APA (6^th Edition):

Miller, J. D. (2017). EXAMINATION OF MUSCLE QUALITY AND MOTOR UNIT BEHAVIOR OF THE FIRST DORSAL INTEROSSEOUS OF NORMAL AND OVERWEIGHT CHILDREN. (Masters Thesis). University of Kansas. Retrieved from http://hdl.handle.net/1808/25951

Chicago Manual of Style (16^th Edition):

Miller, Jonathan Daniel. “EXAMINATION OF MUSCLE QUALITY AND MOTOR UNIT BEHAVIOR OF THE FIRST DORSAL INTEROSSEOUS OF NORMAL AND OVERWEIGHT CHILDREN.” 2017. Masters Thesis, University of Kansas. Accessed April 22, 2021. http://hdl.handle.net/1808/25951.

MLA Handbook (7^th Edition):

Miller, Jonathan Daniel. “EXAMINATION OF MUSCLE QUALITY AND MOTOR UNIT BEHAVIOR OF THE FIRST DORSAL INTEROSSEOUS OF NORMAL AND OVERWEIGHT CHILDREN.” 2017. Web. 22 Apr 2021.

Vancouver:

Miller JD. EXAMINATION OF MUSCLE QUALITY AND MOTOR UNIT BEHAVIOR OF THE FIRST DORSAL INTEROSSEOUS OF NORMAL AND OVERWEIGHT CHILDREN. [Internet] [Masters thesis]. University of Kansas; 2017. [cited 2021 Apr 22]. Available from: http://hdl.handle.net/1808/25951.

Council of Science Editors:

Miller JD. EXAMINATION OF MUSCLE QUALITY AND MOTOR UNIT BEHAVIOR OF THE FIRST DORSAL INTEROSSEOUS OF NORMAL AND OVERWEIGHT CHILDREN. [Masters Thesis]. University of Kansas; 2017. Available from: http://hdl.handle.net/1808/25951

University of Kentucky

20. Agarwal, Anuj. EFFECTS OF ACUTE STRETCH ON CARDIAC ELECTRICAL PROPERTIES IN SWINE.

Degree: 2013, University of Kentucky

URL: https://uknowledge.uky.edu/cbme_etds/10

► Stretch is known to result in an electrically less stable ventricular substrate, yet the reported effects of stretch on measured electrophysiological parameters have been inconsistent… (more)

Subjects/Keywords: Stretch; Restitution; Action potential duration; Hysteresis; Ventricular arrhythmia; Bioelectrical and Neuroengineering

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APA (6^th Edition):

Agarwal, A. (2013). EFFECTS OF ACUTE STRETCH ON CARDIAC ELECTRICAL PROPERTIES IN SWINE. (Doctoral Dissertation). University of Kentucky. Retrieved from https://uknowledge.uky.edu/cbme_etds/10

Chicago Manual of Style (16^th Edition):

Agarwal, Anuj. “EFFECTS OF ACUTE STRETCH ON CARDIAC ELECTRICAL PROPERTIES IN SWINE.” 2013. Doctoral Dissertation, University of Kentucky. Accessed April 22, 2021. https://uknowledge.uky.edu/cbme_etds/10.

MLA Handbook (7^th Edition):

Agarwal, Anuj. “EFFECTS OF ACUTE STRETCH ON CARDIAC ELECTRICAL PROPERTIES IN SWINE.” 2013. Web. 22 Apr 2021.

Vancouver:

Agarwal A. EFFECTS OF ACUTE STRETCH ON CARDIAC ELECTRICAL PROPERTIES IN SWINE. [Internet] [Doctoral dissertation]. University of Kentucky; 2013. [cited 2021 Apr 22]. Available from: https://uknowledge.uky.edu/cbme_etds/10.

Council of Science Editors:

Agarwal A. EFFECTS OF ACUTE STRETCH ON CARDIAC ELECTRICAL PROPERTIES IN SWINE. [Doctoral Dissertation]. University of Kentucky; 2013. Available from: https://uknowledge.uky.edu/cbme_etds/10

University of Minnesota

21. Parthiban, Preethy. Effect of constant-DI pacing on single cell cardiac dynamics.

Degree: MS, Biomedical Engineering, 2020, University of Minnesota

URL: http://hdl.handle.net/11299/217118

► Cardiac alternans, beat-to-beat alternations in action potential duration (APD), is a precursor to fatal arrhythmias such as ventricular fibrillation (VF). Previous research has shown that… (more)

Subjects/Keywords: Action potential; Alternans; Arrhythmias; Constant diastolic interval; Heart; Pacemaker

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APA (6^th Edition):

Parthiban, P. (2020). Effect of constant-DI pacing on single cell cardiac dynamics. (Masters Thesis). University of Minnesota. Retrieved from http://hdl.handle.net/11299/217118

Chicago Manual of Style (16^th Edition):

Parthiban, Preethy. “Effect of constant-DI pacing on single cell cardiac dynamics.” 2020. Masters Thesis, University of Minnesota. Accessed April 22, 2021. http://hdl.handle.net/11299/217118.

MLA Handbook (7^th Edition):

Parthiban, Preethy. “Effect of constant-DI pacing on single cell cardiac dynamics.” 2020. Web. 22 Apr 2021.

Vancouver:

Parthiban P. Effect of constant-DI pacing on single cell cardiac dynamics. [Internet] [Masters thesis]. University of Minnesota; 2020. [cited 2021 Apr 22]. Available from: http://hdl.handle.net/11299/217118.

Council of Science Editors:

Parthiban P. Effect of constant-DI pacing on single cell cardiac dynamics. [Masters Thesis]. University of Minnesota; 2020. Available from: http://hdl.handle.net/11299/217118

22. Telenczuk, Maria. Intracellular and extracellular signatures of action potentials initiated in the axon : Signatures intracellulaires et extracellulaires des potentiels d'action initiés dans l'axone.

Degree: Docteur es, Neurosciences, 2016, Université Pierre et Marie Curie – Paris VI

URL: http://www.theses.fr/2016PA066211

►

Le potentiel d'action est un des événements de signalisation majeurs du cerveau. Ce travail est dédié à l'étude de la génération du potentiel d'action, et… (more)

▼

Le potentiel d'action est un des événements de signalisation majeurs du cerveau. Ce travail est dédié à l'étude de la génération du potentiel d'action, et son impact dans le potentiel extracellulaire ainsi que dans le réseau local. Pour ce faire nous avons abordé trois questions principales. Premièrement, nous nous sommes intéressés à comprendre pourquoi les potentiels d'action ont souvent un début brutal dans les enregistrements somatiques des neurones de mammifères. Nous avons montré que l'hypothèse du couplage résistive critique explique comment le potentiel d'action est initié dans le segment initial de l'axone pour fournir le 'kink' dans le soma. Deuxièmement, nous avons évalué l'impact de la position du segment initial sur le potentiel extracellulaire. De façon importante, nous démontrons que l’impact de la position du segment initial axonal dans la forme et l’amplitude du potentiel d’action dépend de la distance entre le site d’enregistrement et l’axone, et de sa position par rapport à l’axe soma-segment initial axonal.Finalement, nous avons exploré l’impact d’un seul potentiel d’action dans l’activité de réseau, car cet effet est souvent questionné. Nos montrons qu’un seul potentiel d’action d’un neurone pyramidal hippocampique peut commencer l’activité «sharp-wave ripple” qui consiste en l’activation de multiple interneurones. L’ensemble de nos résultats montre que les potentiels d’action sont des événements complexes modelés par la biochimie de le membrane neuronale et la morphologie de l’axone. De plus, ces caractéristiques neuronales modulent fortement leur impact dans le champ extracellulaire et l’activité de réseau.

The action potential is considered one of the major signaling events in the brain.Although it has been studied for years, many questions remain unanswered. The present work is dedicated to the study of action potential generation, its impact on extracellular field and local network establishment. We considered three questions: Firstly, (i) we asked why mammalian neurons often have characteristically sharp onset in the somatic recordings of action potentials. We show that the Critical Resistive Coupling Hypothesis is sufficient to explain how the action potential is initiated in the axon initial segment to provide for the ‘kink’ in the soma, while the Back propagation Hypothesis is not sufficient to explain it. Next, (ii)we asked how the placement of the axon initial segment might affect the extracellular field. We show that the impact of the axon initial segment position on the shape and amplitude ofextracellular action potential depends on the distance between the recording site andthe axon and on its position along the soma–axon initial segment axis. Finally, (iii)we inquired if a single action potential might have an effect on the network activity. Weshow that a single action potential from a single pyramidal neuron in the hippocampus can trigger sharp-wave ripple activity consisting of the firing of multiple interneurons.Altogether, our results show that action potentials are complex…

Advisors/Committee Members: Brette, Romain (thesis director).

Subjects/Keywords: Potentiel d’action; Potentiel intracellulaire et extracellulaire; Excitation; Segment initial de l'axone; Axone; Modèle; Action potential; Intracellular and extracellular potential; Excitation; 573.86

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Telenczuk, M. (2016). Intracellular and extracellular signatures of action potentials initiated in the axon : Signatures intracellulaires et extracellulaires des potentiels d'action initiés dans l'axone. (Doctoral Dissertation). Université Pierre et Marie Curie – Paris VI. Retrieved from http://www.theses.fr/2016PA066211

Chicago Manual of Style (16^th Edition):

Telenczuk, Maria. “Intracellular and extracellular signatures of action potentials initiated in the axon : Signatures intracellulaires et extracellulaires des potentiels d'action initiés dans l'axone.” 2016. Doctoral Dissertation, Université Pierre et Marie Curie – Paris VI. Accessed April 22, 2021. http://www.theses.fr/2016PA066211.

MLA Handbook (7^th Edition):

Telenczuk, Maria. “Intracellular and extracellular signatures of action potentials initiated in the axon : Signatures intracellulaires et extracellulaires des potentiels d'action initiés dans l'axone.” 2016. Web. 22 Apr 2021.

Vancouver:

Telenczuk M. Intracellular and extracellular signatures of action potentials initiated in the axon : Signatures intracellulaires et extracellulaires des potentiels d'action initiés dans l'axone. [Internet] [Doctoral dissertation]. Université Pierre et Marie Curie – Paris VI; 2016. [cited 2021 Apr 22]. Available from: http://www.theses.fr/2016PA066211.

Council of Science Editors:

Telenczuk M. Intracellular and extracellular signatures of action potentials initiated in the axon : Signatures intracellulaires et extracellulaires des potentiels d'action initiés dans l'axone. [Doctoral Dissertation]. Université Pierre et Marie Curie – Paris VI; 2016. Available from: http://www.theses.fr/2016PA066211

23. Diogo Capelin. Caracterização eletrofisiológica em girassol: cinética, rotas de propagação, trocas gasosas e fluorescência da clorofila.

Degree: 2016, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/11/11144/tde-06012017-114716/

►

Esta tese refere-se a pesquisa cujo o principal objetivo foi estudar os efeitos da sinalização elétrica sobre parâmetros fisiológicos de trocas gasosas e fluorescência da… (more)

▼

Esta tese refere-se a pesquisa cujo o principal objetivo foi estudar os efeitos da sinalização elétrica sobre parâmetros fisiológicos de trocas gasosas e fluorescência da clorofila, bem como caracterizar e identificar rotas de propagação de sinais elétricos desencadeados por estímulos de queima em plantas de girassol. Os resultados obtidos a partir deste estudo demonstram que os sinais elétricos desencadeados por estímulo de queima podem ser classificados como potenciais de variação (PV). Estes sinais apresentaram maior facilidade de propagação no eixo vertical da planta atingindo folhas intactas que provavelmente possuem conexão vascular com a folha de estímulo. Apresentaram maior número de eventos de propagação na direção acrópeta da planta e foram incapazes de propagar-se lateralmente não atingindo folhas opostas à de estímulo. Nas folhas opostas onde não houve propagação de PVs foi registrada a ocorrência de hiperpolarização de membranas característica de potencial sistêmico (PS). Quanto aos efeitos fisiológicos do PV, observou-se que este promoveu redução na assimilação líquida de CO2 (A) que provavelmente está relacionada a inativação da fase não fotoquímica da fotossíntese, uma vez que, esteve acompanhada de queda da dissipação fotoquímica dos fotossistemas (qP) e da taxa de transporte de elétrons (ETR). Embora tenha sido registrada alterações na condutância estomática (gs), na concentração intercelular de CO2 (Ci), elevação da dissipação não fotoquímica (qN) e queda na eficiência quântica efetiva do fotossistema II (ΦFSII), estes não foram responsáveis pela queda de A, uma vez que, foram registrados posteriormente a sua redução.

This thesis mainly aimed to study the effects of electrical signaling on physiological parameters of gas exchange and chlorophyll fluorescence, and to characterize and identify route propagation of electrical signals triggered by burning stimuli in sunflower plants. The results from this study demonstrate that the electrical signals triggered by burning stimulus can be classified as variation potentials (VP). These signals showed greater ease of propagation in the vertical axis of the plant, reaching intact leaves that are likely to have vascular connection with the stimulus leaf. They presented greater ease of propagation in acropetal direction of the plant and are unable to spread laterally, not reaching leaves opposed to the stimulus. On opposed leaves, where there was no VPs propagation, it was recorded the occurrence of membrane hyperpolarization of systemic potential (PS). Concerning the physiological effects of PV, it was observed that this promoted a reduction in the liquid CO2 assimilation (A) which is probably related to the inactivation of non-photochemical phase of the photosynthesis, since it was accompanied by the decrease of the photochemical dissipation of the photosystems (qP) and the electron transport rate (ETR). Although changes were recorded in stomatal conductance (gs), CO2 intercellular concentration (Ci), increase of nonphotochemical dissipation…

Advisors/Committee Members: Ricardo Ferraz de Oliveira, Saulo de Tarso Aidar, João Paulo Rodrigues Alves Delfino Barbosa, Ernane José Xavier Costa, Francynês da Conceição Oliveira Macedo.

Subjects/Keywords: Fotossíntese; Potencial de ação; Potencial de variação; Sinalização elétrica; Action potential; Electrical signaling; Photosynthesis; Variation potential

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APA (6^th Edition):

Capelin, D. (2016). Caracterização eletrofisiológica em girassol: cinética, rotas de propagação, trocas gasosas e fluorescência da clorofila. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/11/11144/tde-06012017-114716/

Chicago Manual of Style (16^th Edition):

Capelin, Diogo. “Caracterização eletrofisiológica em girassol: cinética, rotas de propagação, trocas gasosas e fluorescência da clorofila.” 2016. Doctoral Dissertation, University of São Paulo. Accessed April 22, 2021. http://www.teses.usp.br/teses/disponiveis/11/11144/tde-06012017-114716/.

MLA Handbook (7^th Edition):

Capelin, Diogo. “Caracterização eletrofisiológica em girassol: cinética, rotas de propagação, trocas gasosas e fluorescência da clorofila.” 2016. Web. 22 Apr 2021.

Vancouver:

Capelin D. Caracterização eletrofisiológica em girassol: cinética, rotas de propagação, trocas gasosas e fluorescência da clorofila. [Internet] [Doctoral dissertation]. University of São Paulo; 2016. [cited 2021 Apr 22]. Available from: http://www.teses.usp.br/teses/disponiveis/11/11144/tde-06012017-114716/.

Council of Science Editors:

Capelin D. Caracterização eletrofisiológica em girassol: cinética, rotas de propagação, trocas gasosas e fluorescência da clorofila. [Doctoral Dissertation]. University of São Paulo; 2016. Available from: http://www.teses.usp.br/teses/disponiveis/11/11144/tde-06012017-114716/

University of Ottawa

24. Country, Michael. Ca2+ Dynamics in Retinal Horizontal Cells of Teleost Fish: Ca2+-Based Action Potentials and Tolerance to Hypoxia.

Degree: PhD, Sciences / Science, 2020, University of Ottawa

URL: http://dx.doi.org/10.20381/ruor-25355

► Horizontal cells (HCs) are retinal interneurons which provide feedback to photoreceptors to produce visual contrast. They are depolarized by glutamate released from photoreceptors, leading to… (more)

▼ Horizontal cells (HCs) are retinal interneurons which provide feedback to photoreceptors to produce visual contrast. They are depolarized by glutamate released from photoreceptors, leading to a constant influx of Ca2+ which would be fatal to most neurons. In addition, HCs present spontaneous Ca2+-based action potentials, which are poorly understood and whose function is unknown. Given these unique Ca2+ dynamics, the present thesis sought to define action potentials (APs) and mechanisms of Ca2+ homeostasis in HCs. APs were observed in isolated goldfish HCs with electrophysiology, Ca2+ imaging, and voltage-sensitive dye imaging. Pharmacological inhibition of ion channels suggests APs required extracellular Ca2+ entry via L-type Ca2+ channels, followed by Ca2+-induced Ca2+ release from ryanodine receptors. Next, we developed a novel system to classify all four HC subtypes in vitro, and validated it with immunocytochemistry for a subtype-specific biomarker. All subtypes presented APs, although frequency and duration varied by subtype. APs were also found in HCs of tissue slices prepared from whole retina, where similar trends were found between subtype, frequency, and duration. This highlights subtype-specific differences in Ca2+ dynamics. Lastly, [Ca2+]i was monitored throughout hypoxia in HCs of the hypoxia-tolerant goldfish and the hypoxia-sensitive rainbow trout. In Ca2+ imaging experiments, hypoxia destabilized [Ca2+]i in HCs of trout; but in goldfish, HCs were resistant to the effects of hypoxia. However, when mitochondrial ATP-dependent K+ (mKATP) channels were inhibited, goldfish HCs lost the ability to maintain [Ca2+]i homeostasis during hypoxia. By contrast, in trout HCs, opening of mKATP stabilized [Ca2+]i during hypoxia. Furthermore, in goldfish, hypoxia protected against increases in [Ca2+]i caused by inhibiting glycolysis, showing that hypoxia is not just tolerated, but is actively protective in goldfish HCs. The present thesis includes the first comprehensive description of spontaneous Ca2+-based APs in HCs, and introduces the first cellular model of intrinsic hypoxic neuroprotection in the vertebrate retina. Advisors/Committee Members: Jonz, Michael (supervisor).

Subjects/Keywords: retina; calcium; goldfish; hypoxia; horizontal cell; rainbow trout; trout; subtype; morphometrics; morphology; action potential; action potentials; mKATP

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Country, M. (2020). Ca2+ Dynamics in Retinal Horizontal Cells of Teleost Fish: Ca2+-Based Action Potentials and Tolerance to Hypoxia. (Doctoral Dissertation). University of Ottawa. Retrieved from http://dx.doi.org/10.20381/ruor-25355

Chicago Manual of Style (16^th Edition):

Country, Michael. “Ca2+ Dynamics in Retinal Horizontal Cells of Teleost Fish: Ca2+-Based Action Potentials and Tolerance to Hypoxia.” 2020. Doctoral Dissertation, University of Ottawa. Accessed April 22, 2021. http://dx.doi.org/10.20381/ruor-25355.

MLA Handbook (7^th Edition):

Country, Michael. “Ca2+ Dynamics in Retinal Horizontal Cells of Teleost Fish: Ca2+-Based Action Potentials and Tolerance to Hypoxia.” 2020. Web. 22 Apr 2021.

Vancouver:

Country M. Ca2+ Dynamics in Retinal Horizontal Cells of Teleost Fish: Ca2+-Based Action Potentials and Tolerance to Hypoxia. [Internet] [Doctoral dissertation]. University of Ottawa; 2020. [cited 2021 Apr 22]. Available from: http://dx.doi.org/10.20381/ruor-25355.

Council of Science Editors:

Country M. Ca2+ Dynamics in Retinal Horizontal Cells of Teleost Fish: Ca2+-Based Action Potentials and Tolerance to Hypoxia. [Doctoral Dissertation]. University of Ottawa; 2020. Available from: http://dx.doi.org/10.20381/ruor-25355

University of Kentucky

25. Thyagarajan, Sridevi. ADRENERGIC STIMULATION IN ACUTE HYPERGLYCEMIA: EFFECTS ON CELLULAR AND TISSUE LEVEL MURINE CARDIAC ELECTROPHYSIOLOGY.

Degree: 2018, University of Kentucky

URL: https://uknowledge.uky.edu/cbme_etds/49

► Cardiovascular complications associated with elevated levels of glucose in the blood (Hyperglycemia, HG) is a growing health concern. HG is known to be associated with… (more)

▼ Cardiovascular complications associated with elevated levels of glucose in the blood (Hyperglycemia, HG) is a growing health concern. HG is known to be associated with a variety of cardiovascular morbidities including higher incidence of electrical disturbances. Although effects of chronic HG have been widely investigated, electrophysiological effects of acute hyperglycemia are relatively less known. Further, hyperglycemic effects on adrenergic response is not widely investigated. We used excised ventricular tissues from mice to record trans-membrane potentials during a variety of pacing protocols to investigate cellular/tissue level electrophysiological effects of acute hyperglycemia and adrenergic stimulation (1µM Isoproterenol, a β-adrenergic agonist). A custom program was used to compute action potential durations (APD), maximal rates of depolarization (dv/dtmax), and action potential amplitudes (APA) from the recorded trans-membrane potentials. From these computed measures, electrical restitution and alternans threshold were quantified. Restitution was quantified using the Standard Protocol (SP; basic cycle length BCL= 200ms), Dynamic Protocol (DP; 200-40ms or until blockade) and a novel diastolic interval (DI) control protocol with Sinusoidal Changes in DI. Results from 6 mice show that acute hyperglycemia causes prolongation of the APD. Effects of adrenergic stimulation during acute hyperglycemia were partially blunted compared with non-hyperglycemic state, i.e. hyperglycemia minimized the decrease in APD that was produced by adrenergic stimulation. Similar, but less consistent (across animals) effects were seen in other electrophysiological parameters such as alternans threshold. These results show that acute hyperglycemia may itself alter cellular level electrophysiology of myocytes and importantly, modify adrenergic response. These results suggest that in addition to long term re-modeling that occurs in diabetes, acute changes in glucose levels also affect electrical function and further may contribute to systemically observed changes in diabetes by blunting adrenergic response. Therefore, further investigation into the electrophysiological effects of acute changes in glucose levels are warranted.

Subjects/Keywords: Action potential duration (APD); acute hyperglycemia; maximal rates of depolarization (dv/dtmax) action potential amplitudes (APA); Dynamic protocol; Standard protocol; Sinusoidal DI control; Biomedical Engineering and Bioengineering; Cardiovascular Diseases

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Thyagarajan, S. (2018). ADRENERGIC STIMULATION IN ACUTE HYPERGLYCEMIA: EFFECTS ON CELLULAR AND TISSUE LEVEL MURINE CARDIAC ELECTROPHYSIOLOGY. (Masters Thesis). University of Kentucky. Retrieved from https://uknowledge.uky.edu/cbme_etds/49

Chicago Manual of Style (16^th Edition):

Thyagarajan, Sridevi. “ADRENERGIC STIMULATION IN ACUTE HYPERGLYCEMIA: EFFECTS ON CELLULAR AND TISSUE LEVEL MURINE CARDIAC ELECTROPHYSIOLOGY.” 2018. Masters Thesis, University of Kentucky. Accessed April 22, 2021. https://uknowledge.uky.edu/cbme_etds/49.

MLA Handbook (7^th Edition):

Thyagarajan, Sridevi. “ADRENERGIC STIMULATION IN ACUTE HYPERGLYCEMIA: EFFECTS ON CELLULAR AND TISSUE LEVEL MURINE CARDIAC ELECTROPHYSIOLOGY.” 2018. Web. 22 Apr 2021.

Vancouver:

Thyagarajan S. ADRENERGIC STIMULATION IN ACUTE HYPERGLYCEMIA: EFFECTS ON CELLULAR AND TISSUE LEVEL MURINE CARDIAC ELECTROPHYSIOLOGY. [Internet] [Masters thesis]. University of Kentucky; 2018. [cited 2021 Apr 22]. Available from: https://uknowledge.uky.edu/cbme_etds/49.

Council of Science Editors:

Thyagarajan S. ADRENERGIC STIMULATION IN ACUTE HYPERGLYCEMIA: EFFECTS ON CELLULAR AND TISSUE LEVEL MURINE CARDIAC ELECTROPHYSIOLOGY. [Masters Thesis]. University of Kentucky; 2018. Available from: https://uknowledge.uky.edu/cbme_etds/49

NSYSU

26. Lee, Chuan-Te. Properties of Action Potential Waveform-Evoked L-type Calcium Currents in Pituitary GH3 Cells.

Degree: Master, Biological Sciences, 2002, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0620102-192529

► The purpose of this study was to examine the time course and kinetics of L-type Ca2+ current (ICa,L) from pituitary GH3 cells in response to… (more)

Subjects/Keywords: ACTION POTENTIAL; GH3; PATCH CLAMP; TRH

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lee, C. (2002). Properties of Action Potential Waveform-Evoked L-type Calcium Currents in Pituitary GH3 Cells. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0620102-192529

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lee, Chuan-Te. “Properties of Action Potential Waveform-Evoked L-type Calcium Currents in Pituitary GH3 Cells.” 2002. Thesis, NSYSU. Accessed April 22, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0620102-192529.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lee, Chuan-Te. “Properties of Action Potential Waveform-Evoked L-type Calcium Currents in Pituitary GH3 Cells.” 2002. Web. 22 Apr 2021.

Vancouver:

Lee C. Properties of Action Potential Waveform-Evoked L-type Calcium Currents in Pituitary GH3 Cells. [Internet] [Thesis]. NSYSU; 2002. [cited 2021 Apr 22]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0620102-192529.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lee C. Properties of Action Potential Waveform-Evoked L-type Calcium Currents in Pituitary GH3 Cells. [Thesis]. NSYSU; 2002. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0620102-192529

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

27. Wu, Yen-cheng. A Neuron Emulator and Headstage Circuit for Patch Clamp Setups.

Degree: Master, Electrical Engineering, 2012, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0815112-163439

► This thesis presents a neuron emulator and headstage circuit for patch clamp setups and provides simulation, measurement and verification results. The circuit implemented on a… (more)

Subjects/Keywords: patch clamp; neuron emulator; headstage; single electrode; action potential; current clamp; voltage clamp

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wu, Y. (2012). A Neuron Emulator and Headstage Circuit for Patch Clamp Setups. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0815112-163439

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wu, Yen-cheng. “A Neuron Emulator and Headstage Circuit for Patch Clamp Setups.” 2012. Thesis, NSYSU. Accessed April 22, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0815112-163439.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wu, Yen-cheng. “A Neuron Emulator and Headstage Circuit for Patch Clamp Setups.” 2012. Web. 22 Apr 2021.

Vancouver:

Wu Y. A Neuron Emulator and Headstage Circuit for Patch Clamp Setups. [Internet] [Thesis]. NSYSU; 2012. [cited 2021 Apr 22]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0815112-163439.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wu Y. A Neuron Emulator and Headstage Circuit for Patch Clamp Setups. [Thesis]. NSYSU; 2012. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0815112-163439

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Dalhousie University

28. MacLeod, Sarah. Effects of wildtype and mutant forms of atrial natriuretic peptide on L-type Ca2+ current in mouse atrial myocytes.

Degree: MS, Department of Physiology & Biophysics, 2016, Dalhousie University

URL: http://hdl.handle.net/10222/71595

► Atrial natriuretic peptide (ANP) is a hormone with numerous effects in the cardiovascular system, including ion channel physiology. Genetic mapping of a family with hereditary… (more)

Subjects/Keywords: natriuretic peptides; natriuretic peptide receptors; action potential; ion channels; atrial fibrillation; cardiac electrophysiology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

MacLeod, S. (2016). Effects of wildtype and mutant forms of atrial natriuretic peptide on L-type Ca2+ current in mouse atrial myocytes. (Masters Thesis). Dalhousie University. Retrieved from http://hdl.handle.net/10222/71595

Chicago Manual of Style (16^th Edition):

MacLeod, Sarah. “Effects of wildtype and mutant forms of atrial natriuretic peptide on L-type Ca2+ current in mouse atrial myocytes.” 2016. Masters Thesis, Dalhousie University. Accessed April 22, 2021. http://hdl.handle.net/10222/71595.

MLA Handbook (7^th Edition):

MacLeod, Sarah. “Effects of wildtype and mutant forms of atrial natriuretic peptide on L-type Ca2+ current in mouse atrial myocytes.” 2016. Web. 22 Apr 2021.

Vancouver:

MacLeod S. Effects of wildtype and mutant forms of atrial natriuretic peptide on L-type Ca2+ current in mouse atrial myocytes. [Internet] [Masters thesis]. Dalhousie University; 2016. [cited 2021 Apr 22]. Available from: http://hdl.handle.net/10222/71595.

Council of Science Editors:

MacLeod S. Effects of wildtype and mutant forms of atrial natriuretic peptide on L-type Ca2+ current in mouse atrial myocytes. [Masters Thesis]. Dalhousie University; 2016. Available from: http://hdl.handle.net/10222/71595

UCLA

29. Lake, Michael. Development of Nitrogen Vacancy Diamond Centers for Nanoscale Sensing of Physical and Biological Materials.

Degree: Chemistry, 2018, UCLA

URL: http://www.escholarship.org/uc/item/54j9t82j

► The NV defect center in diamond forms a pseudo-atomic quantum system with discreet optically excitable transitions between ground and excited states in the gap between… (more)

▼ The NV defect center in diamond forms a pseudo-atomic quantum system with discreet optically excitable transitions between ground and excited states in the gap between valence and conduction bands, making the NV center a deep-level defect center in diamond. For the negatively charged NV center (NV-), both the ground and excited states are spin triplets (S=1) and coupling between optical and spin states provides unique opportunities for optical detection of magnetic resonance (ODMR) and quantum metrology under ambient conditions. As an atomically sized point defect that is stable in single nanodiamonds as small as a few nanometers, the NV center enables spin based imaging of temperature, electric fields, magnetic fields and mechanical strain with nanoscale spatial resolution. Made of carbon, nanodiamonds are also ideal nanoparticles for use in biological systems, exhibiting extremely low cytotoxicity, no photo bleaching and exceptional contrast in transmission electron and light microscopy. With the ability to act as both a passive, non perturbing sensor (e.g. a diamagnetic material used for sensing magnetic fields) and a connection point for two way, direct coupling of far field optics to NV^- spins and indirectly to the highly localized neighborhood of atoms, electronic states and phonon modes in the local vicinity, NV diamond provides a route to nanoscale field sensing and spin based optical microscopy. These sensors are also stable in nanodiamonds. For nanoparticles, the reduction in particle diameter dramatically enhances the proportion of the material that is surface exposed, enhancing any surface related properties. Nitrogen Vacancy centers in nanodiamonds provide another example of material properties that vary with particle size. In chapter 5, evidence that modulation of nanodiamonds fluorescent emissions by electrical perturbations in their surrouding environment allows transduction of local electrodynamics into a far field optical signal capable of mapping action potentials in cardiomyocytes in presented. The unifying theme for all of the work presented in this dissertation is to enable the use of magnetic resonance signals and interactions for imaging and sensing in previously inaccessible regimes. The specific focus is on methods and techniques to enable nanoscale physical sensing and functional imaging in live tissues, with the ultimate aim to lay the predicate for the combination of both without compromise.

Subjects/Keywords: Physical chemistry; Action Potential; Electron Microscopy; Magnetic Resonance; Nanodiamond; Nitrogen Vacancy Diamond; Nuclear Pore

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lake, M. (2018). Development of Nitrogen Vacancy Diamond Centers for Nanoscale Sensing of Physical and Biological Materials. (Thesis). UCLA. Retrieved from http://www.escholarship.org/uc/item/54j9t82j

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lake, Michael. “Development of Nitrogen Vacancy Diamond Centers for Nanoscale Sensing of Physical and Biological Materials.” 2018. Thesis, UCLA. Accessed April 22, 2021. http://www.escholarship.org/uc/item/54j9t82j.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lake, Michael. “Development of Nitrogen Vacancy Diamond Centers for Nanoscale Sensing of Physical and Biological Materials.” 2018. Web. 22 Apr 2021.

Vancouver:

Lake M. Development of Nitrogen Vacancy Diamond Centers for Nanoscale Sensing of Physical and Biological Materials. [Internet] [Thesis]. UCLA; 2018. [cited 2021 Apr 22]. Available from: http://www.escholarship.org/uc/item/54j9t82j.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lake M. Development of Nitrogen Vacancy Diamond Centers for Nanoscale Sensing of Physical and Biological Materials. [Thesis]. UCLA; 2018. Available from: http://www.escholarship.org/uc/item/54j9t82j

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

30. Nayara Nascimento Moraes. Desenvolvimento e implementação de um sensor hibrido não invasivo de eletromiografia e mecanomiografia para registros de potenciais de ação de uma unidade motora.

Degree: 2010, Federal University of Uberlândia

URL: http://www.bdtd.ufu.br//tde_busca/arquivo.php?codArquivo=3591

►

Mais de 40 tipos de distrofias musculares são atualmente conhecidos, dados de 2003 indicavam que cerca de 80 mil brasileiros eram acometidos por estas disfunções.… (more)

▼

Mais de 40 tipos de distrofias musculares são atualmente conhecidos, dados de 2003 indicavam que cerca de 80 mil brasileiros eram acometidos por estas disfunções. Um tipo de exame usado no auxílio ao diagnóstico dessas distrofias musculares é a eletroneuromiografia, a qual visa avaliar a atividade elétrica no músculo. A realização desse exame conta com a utilização de eletrodos de agulha, os quais analisam a morfologia dos potenciais de ação das fibras musculares bem como seu padrão de recrutamento. Apesar do caráter invasivo dos eletrodos usados, métodos como a eletromiografia de superfície não têm se mostrado eficazes no registro individual de potenciais de ação. Neste sentido, a proposta deste trabalho é desenvolver um sensor hibrido de eletromiografia e mecanomiografia que registre potenciais de ação de uma unidade motora por meio de métodos não invasivos. O sensor de eletromiografia construído é constituido de dois eletrólitos confeccionados por meio de uma liga de prata-cloreto de prata, de 99% de pureza, área de 1mm (1mm de lado) e a distância inter-eletrodo de 3mm. O eletrodo é ativo e utiliza a configuração bipolar, apresentando ganho de 20 vezes e CMRR superior a 120dB. Já o sensor de mecanomiografia conta com um transdutor de acelerometria, cujo circuito integrado usado foi o MMA7260 da Freescale. Este apresenta 800mV/g de sensibilidade, nível de ruído de 350μg/(Hz) e banda de freqüência de 350Hz. Os testes realizados mostraram a eficiência do sensor desenvolvido para registros de potenciais de ação de uma unidade motora em condições de baixa atividade muscular e músculos superficiais.

More than 40 types of muscular dystrophy are currently known, which in 2003 had affected more than 80,000 brazilians. One type of medical test used as an aid in the diagnosis of these muscular dystrophies is the electroneuromyography, which aims to evaluate muscle electrical activity. To performance this test needle electrodes are used, which analyze the morphology of muscle fibers action potentials and their recruitment pattern. Despite the invasive nature of the used electrodes, methods such as surface electromyography have not been effective in individual action potentials records. Thus, this study proposed to develop a hybrid electromyography and mechanomyography sensor which records a motor unit action potential through noninvasive methods. So, the EMG sensors are built up of two electrolytes prepared using an alloy of silver-silver chloride, 99% purity, area of 1mm (1mm side) and the inter-electrode distance of 3mm. The electrode is active and the configuration used is bipolar, with gain of 20 times and CMRR exceed 120dB. The mechanomyography sensor has an accelerometry transducer, whose used chip was Freescale MMA7260. It features 800mV/g of sensitivity, noise level of 350μg/Hz and 350Hz frequency band. The tests performed show the efficiency of the developed sensor to record motor unit action potentials in low muscle activity levels and superficial muscles.

Advisors/Committee Members: Adriano Alves Pereira, Eduardo Lázaro Martins Naves.

Subjects/Keywords: ENGENHARIA ELETRICA; Sensor; Mecanomiografia; Potencial de Ação; Eletromiografia; Electromyography; Mechanomyography; Action potential

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Moraes, N. N. (2010). Desenvolvimento e implementação de um sensor hibrido não invasivo de eletromiografia e mecanomiografia para registros de potenciais de ação de uma unidade motora. (Thesis). Federal University of Uberlândia. Retrieved from http://www.bdtd.ufu.br//tde_busca/arquivo.php?codArquivo=3591

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Moraes, Nayara Nascimento. “Desenvolvimento e implementação de um sensor hibrido não invasivo de eletromiografia e mecanomiografia para registros de potenciais de ação de uma unidade motora.” 2010. Thesis, Federal University of Uberlândia. Accessed April 22, 2021. http://www.bdtd.ufu.br//tde_busca/arquivo.php?codArquivo=3591.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Moraes, Nayara Nascimento. “Desenvolvimento e implementação de um sensor hibrido não invasivo de eletromiografia e mecanomiografia para registros de potenciais de ação de uma unidade motora.” 2010. Web. 22 Apr 2021.

Vancouver:

Moraes NN. Desenvolvimento e implementação de um sensor hibrido não invasivo de eletromiografia e mecanomiografia para registros de potenciais de ação de uma unidade motora. [Internet] [Thesis]. Federal University of Uberlândia; 2010. [cited 2021 Apr 22]. Available from: http://www.bdtd.ufu.br//tde_busca/arquivo.php?codArquivo=3591.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Moraes NN. Desenvolvimento e implementação de um sensor hibrido não invasivo de eletromiografia e mecanomiografia para registros de potenciais de ação de uma unidade motora. [Thesis]. Federal University of Uberlândia; 2010. Available from: http://www.bdtd.ufu.br//tde_busca/arquivo.php?codArquivo=3591

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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Open Access Theses and Dissertations