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You searched for subject:(Zinc Binding Group). Showing records 1 – 4 of 4 total matches.

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Miami University

1. yang, hao. SPECTROSCOPIC CHARACTERIZATION OF ZINC HYDROLASES NDM-1 AND MMP-1 FOR DRUG DISCOVERY.

Degree: PhD, Chemistry, 2015, Miami University

 A myriad of zinc hydrolases have been recognized as biochemically-important targets for different diseases; however, structural and functional studies on these enzymes are often hindered… (more)

Subjects/Keywords: Biochemistry; Chemistry; Metallo-beta-lactamase, NDM-1, MMP-1, spectroscopy, drug discovery, zinc binding group

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APA (6th Edition):

yang, h. (2015). SPECTROSCOPIC CHARACTERIZATION OF ZINC HYDROLASES NDM-1 AND MMP-1 FOR DRUG DISCOVERY. (Doctoral Dissertation). Miami University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=miami1437835452

Chicago Manual of Style (16th Edition):

yang, hao. “SPECTROSCOPIC CHARACTERIZATION OF ZINC HYDROLASES NDM-1 AND MMP-1 FOR DRUG DISCOVERY.” 2015. Doctoral Dissertation, Miami University. Accessed March 05, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=miami1437835452.

MLA Handbook (7th Edition):

yang, hao. “SPECTROSCOPIC CHARACTERIZATION OF ZINC HYDROLASES NDM-1 AND MMP-1 FOR DRUG DISCOVERY.” 2015. Web. 05 Mar 2021.

Vancouver:

yang h. SPECTROSCOPIC CHARACTERIZATION OF ZINC HYDROLASES NDM-1 AND MMP-1 FOR DRUG DISCOVERY. [Internet] [Doctoral dissertation]. Miami University; 2015. [cited 2021 Mar 05]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=miami1437835452.

Council of Science Editors:

yang h. SPECTROSCOPIC CHARACTERIZATION OF ZINC HYDROLASES NDM-1 AND MMP-1 FOR DRUG DISCOVERY. [Doctoral Dissertation]. Miami University; 2015. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=miami1437835452

2. Rouanet Mehouas, Cécile. Conception de ligands à vocation thérapeutique : combinaison d'approches multidisciplinaires pour comprendre les interactions intermoléculaires : Design of therapeutic compounds : Combination of multidisciplinary approaches to get deeper insight into intermolecular interactions.

Degree: Docteur es, Biochimie et biologie structurale, 2015, Université Paris-Saclay (ComUE)

Les mécanismes de reconnaissance moléculaire sont à la base de nombreuses fonction biologiques essentielles (transduction du signal, régulation de l’expression génique, stimulation du système immunitaire,...).… (more)

Subjects/Keywords: Mmp-12; Inhibition; Protonation; Itc; Cristallographie; Groupement chélatant du Zinc; Mmp-12; Inhibition; Protonation; Itc; Crystallography; Zinc Binding Group

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APA (6th Edition):

Rouanet Mehouas, C. (2015). Conception de ligands à vocation thérapeutique : combinaison d'approches multidisciplinaires pour comprendre les interactions intermoléculaires : Design of therapeutic compounds : Combination of multidisciplinary approaches to get deeper insight into intermolecular interactions. (Doctoral Dissertation). Université Paris-Saclay (ComUE). Retrieved from http://www.theses.fr/2015SACLS145

Chicago Manual of Style (16th Edition):

Rouanet Mehouas, Cécile. “Conception de ligands à vocation thérapeutique : combinaison d'approches multidisciplinaires pour comprendre les interactions intermoléculaires : Design of therapeutic compounds : Combination of multidisciplinary approaches to get deeper insight into intermolecular interactions.” 2015. Doctoral Dissertation, Université Paris-Saclay (ComUE). Accessed March 05, 2021. http://www.theses.fr/2015SACLS145.

MLA Handbook (7th Edition):

Rouanet Mehouas, Cécile. “Conception de ligands à vocation thérapeutique : combinaison d'approches multidisciplinaires pour comprendre les interactions intermoléculaires : Design of therapeutic compounds : Combination of multidisciplinary approaches to get deeper insight into intermolecular interactions.” 2015. Web. 05 Mar 2021.

Vancouver:

Rouanet Mehouas C. Conception de ligands à vocation thérapeutique : combinaison d'approches multidisciplinaires pour comprendre les interactions intermoléculaires : Design of therapeutic compounds : Combination of multidisciplinary approaches to get deeper insight into intermolecular interactions. [Internet] [Doctoral dissertation]. Université Paris-Saclay (ComUE); 2015. [cited 2021 Mar 05]. Available from: http://www.theses.fr/2015SACLS145.

Council of Science Editors:

Rouanet Mehouas C. Conception de ligands à vocation thérapeutique : combinaison d'approches multidisciplinaires pour comprendre les interactions intermoléculaires : Design of therapeutic compounds : Combination of multidisciplinary approaches to get deeper insight into intermolecular interactions. [Doctoral Dissertation]. Université Paris-Saclay (ComUE); 2015. Available from: http://www.theses.fr/2015SACLS145

3. Dlamini, Samkeliso Mpendulo, Dlamini. Synthesis and Biological Evaluation of HDAC Inhibitors with 1-(1H-imidazol-2-yl)ethan-1-one Moiety as the Metal-Binding Group.

Degree: MS, Medicinal Chemistry, 2017, University of Toledo

 Synthesis and Biological Evaluation of HDAC Inhibitors with 1-(1H-imidazol-2-yl)ethan-1-one Moiety as the Metal-Binding GroupBySamkeliso M DlaminiSubmitted to the Graduate Faculty as partial fulfillment of the… (more)

Subjects/Keywords: Chemistry; HDAC; HDAC inhibitor; Zinc binding group; SAHA; Cancer

…25 Figure 17. Mechanism base zinc binding group… …x28;CBHA).15 The most popular zinc-binding group is the hydroxamate moiety.16 All HDACi… …hydroxamate as the zinc-binding group.16 These HDACis have shown significant potency on cancer cells… …21 Figure 14. Hydroxamic acid metal binding group… …24 Figure 15. Mono-dentate zinc binding groups… 

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APA (6th Edition):

Dlamini, Samkeliso Mpendulo, D. (2017). Synthesis and Biological Evaluation of HDAC Inhibitors with 1-(1H-imidazol-2-yl)ethan-1-one Moiety as the Metal-Binding Group. (Masters Thesis). University of Toledo. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=toledo1501770195684609

Chicago Manual of Style (16th Edition):

Dlamini, Samkeliso Mpendulo, Dlamini. “Synthesis and Biological Evaluation of HDAC Inhibitors with 1-(1H-imidazol-2-yl)ethan-1-one Moiety as the Metal-Binding Group.” 2017. Masters Thesis, University of Toledo. Accessed March 05, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1501770195684609.

MLA Handbook (7th Edition):

Dlamini, Samkeliso Mpendulo, Dlamini. “Synthesis and Biological Evaluation of HDAC Inhibitors with 1-(1H-imidazol-2-yl)ethan-1-one Moiety as the Metal-Binding Group.” 2017. Web. 05 Mar 2021.

Vancouver:

Dlamini, Samkeliso Mpendulo D. Synthesis and Biological Evaluation of HDAC Inhibitors with 1-(1H-imidazol-2-yl)ethan-1-one Moiety as the Metal-Binding Group. [Internet] [Masters thesis]. University of Toledo; 2017. [cited 2021 Mar 05]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=toledo1501770195684609.

Council of Science Editors:

Dlamini, Samkeliso Mpendulo D. Synthesis and Biological Evaluation of HDAC Inhibitors with 1-(1H-imidazol-2-yl)ethan-1-one Moiety as the Metal-Binding Group. [Masters Thesis]. University of Toledo; 2017. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=toledo1501770195684609

4. Alqahtani, Abdulateef, Alqarni. Synthesis and Biological Evaluation of New HDAC Inhibitors.

Degree: MS, Medicinal Chemistry, 2018, University of Toledo

 Cancer is the second leading cause of death in the United States of America and the entire world and the disease burden is exacerbated due… (more)

Subjects/Keywords: Chemistry; Pharmaceuticals; Pharmacy Sciences; HDAC, HDAC inhibitors, Zinc binding group, DNA, Gene expression

zinc binding 40 groups (Figure 9). A. Hydroxamic acid metal-binding group B… …zinc binding groups xiv List of Schemes Scheme 1. Retrosynthetic approach to HDAC… …lysine side chain enabling the access of the zinc ion, and a cap group, generally an aromatic… …The widely used ZBGs are hydroximic acids, Mono-dentate zinc binding groups, and Bidentate… …Mono-dentate zinc binding groups: i. Pyrimidinetrione ii. Thiadiazole iii.Thiadiazine C. C… 

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Alqahtani, Abdulateef, A. (2018). Synthesis and Biological Evaluation of New HDAC Inhibitors. (Masters Thesis). University of Toledo. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=toledo1525448898248748

Chicago Manual of Style (16th Edition):

Alqahtani, Abdulateef, Alqarni. “Synthesis and Biological Evaluation of New HDAC Inhibitors.” 2018. Masters Thesis, University of Toledo. Accessed March 05, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1525448898248748.

MLA Handbook (7th Edition):

Alqahtani, Abdulateef, Alqarni. “Synthesis and Biological Evaluation of New HDAC Inhibitors.” 2018. Web. 05 Mar 2021.

Vancouver:

Alqahtani, Abdulateef A. Synthesis and Biological Evaluation of New HDAC Inhibitors. [Internet] [Masters thesis]. University of Toledo; 2018. [cited 2021 Mar 05]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=toledo1525448898248748.

Council of Science Editors:

Alqahtani, Abdulateef A. Synthesis and Biological Evaluation of New HDAC Inhibitors. [Masters Thesis]. University of Toledo; 2018. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=toledo1525448898248748

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