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You searched for subject:(Zalcitabine). Showing records 1 – 2 of 2 total matches.

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University of Georgia

1. Xu, Meng. Quantitative analysis and pharmacokinetics of antiviral agents in the pregnant rat.

Degree: 2014, University of Georgia

Antiviral drugs are used therapeutically in pregnancy for treatment of both mother and fetus. Antiviral drugs are presumed to prevent viral transmission from mother to fetus by decreasing maternal viral load and/or accumulation of the drugs in the fetal compartment. Due to a number of reasons, pregnant women are generally not used during clinical trials, so very little is known about the behavior of therapeutic agents during pregnancy. A pregnant rat model has been developed to investigate the pharmacokinetics and placental transport of antivirals during pregnancy. Presented here are validated analytical methods for the extraction and quantitation of the nucleoside reverse transcriptase inhibitors zalcitabine (DDC) and stavudine (D4T) in the various matrices needed to support the maternal-fetal pharmacokinetic studies. Also presented here are the pharmacokinetics of DDC and D4T, using the pregnant rat model.

Subjects/Keywords: Analytical; Pharmacokinetics; HIV; Zalcitabine; DDC; Stavudine; D4T; Lamivudine; 3TC; placental transport; fetal disposition

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Xu, M. (2014). Quantitative analysis and pharmacokinetics of antiviral agents in the pregnant rat. (Thesis). University of Georgia. Retrieved from http://hdl.handle.net/10724/25093

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Xu, Meng. “Quantitative analysis and pharmacokinetics of antiviral agents in the pregnant rat.” 2014. Thesis, University of Georgia. Accessed April 15, 2021. http://hdl.handle.net/10724/25093.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Xu, Meng. “Quantitative analysis and pharmacokinetics of antiviral agents in the pregnant rat.” 2014. Web. 15 Apr 2021.

Vancouver:

Xu M. Quantitative analysis and pharmacokinetics of antiviral agents in the pregnant rat. [Internet] [Thesis]. University of Georgia; 2014. [cited 2021 Apr 15]. Available from: http://hdl.handle.net/10724/25093.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Xu M. Quantitative analysis and pharmacokinetics of antiviral agents in the pregnant rat. [Thesis]. University of Georgia; 2014. Available from: http://hdl.handle.net/10724/25093

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Pontifical Catholic University of Rio de Janeiro

2. KATIA CHRISTINA LEANDRO ANTUNES. [en] DEVELOPMENT OF ELECTROANALYTICALS METODOLOGY FOR DETERMINATION OF ZIDOVUDINE, LAMIVUDINE AND ZALCITABINE.

Degree: 2004, Pontifical Catholic University of Rio de Janeiro

[pt] O comportamento eletroquímico e o desenvolvimento de metodologias eletroanalíticas para a determinação de zidovudina (AZT), lamivudina (3TC) e zalcitabina (DDC) em medicamentos foram investigados no presente trabalhoatravés de técnicas voltamétricas. Estas substâncias possuem atividade antiretroviral, sendo utilizadas no tratamento de indivíduos portadores de HIV. AZT, 3TC e DDC sofrem redução na superfície do eletrodo de mercúrio. Ainfluência dos parâmetros eletroquímicos, tais como, velocidade de varredura, amplitude, natureza do eletrólito suporte e pH foram estudados para selecionar as melhores condições para quantificar estes princípios ativos em formulações farmacêuticas. A redução da zidovudina ocorre em apenas uma etapa, sendo esta atribuída à redução do grupo azida (-N3), originando em um pico de potencial de-970 mV vs Ag/AgCl (3 mol L-1), utilizando tampão fosfato, pH 8,0. A faixa linear encontrada foi de 0,25 a 1,25 mg L-1. O mecanismo de redução da zidovudina envolve a participação de 4 elétrons e 2 prótons. Adicionalmente novos estudos eletroquímicos foram desenvolvidos para a determinação de lamivudina e de zalcitabina através da voltametria em pulso diferencial em tampão Clark-Lubs, pH 2,0, onde se obteve um pico no potencial de -1160 e -1180 mV, respectivamente. Lamivudina obteve faixa linear de 2,28 a 8,85 mg L-1 e zalcitabina de 10,0 a 23,3 mg L-1. O mecanismo de redução destas drogas envolve a participação de números iguais de prótons e elétrons. Todas as metodologias desenvolvidas também foram validadas.

[en] The electrochemical behaviour and the development of an analytical methodology for the zidovudine (AZT), lamivudine (3TC) and zalcitabine (DDC)determination in drugs using voltammetrics techniques were the objectives of the current study. These drugs have been extensively used in the treatment of HIV patients because its antiretroviral activity. The AZT, 3TC and DDC are reduced at a hanging mercury drop electrode (HMDE). The influence of electroanalytical parameters such as, scan rate, amplitude, nature of the support electrolyte and pH in the signal was verified to select the best conditions for quantifying these drugs in pharmaceutical forms. The obtained results had showed AZT, in solution of pH 8.0 of phosphate buffer, with only one reduction in -970 mV vs Ag/AgCl (3 mol L-1). This peak is due to reduction of the azido group present on zidovudine molecule. The linear range of standards is from 0.25 to 1.25 mg L-1. The electrodic mechanism involving the participation of 4 electrons and 2 protons in the reduction of AZT molecules. News studies were development for lamivudine and zalcitabine determination by differential pulse voltammetry in solution of pH 2.0 of Clark-Lubs buffer, with only one reduction in - 1160 and -1180 mV, respectively. Lamivudine has been the linear range of standards from 2.28 to 8.85 mg L-1 and zalcitabine from 10.0 to 23.3 mg L-1. The mechanism of these drugs involving the participation of the same number of electrons and protons. All these analytical…

Advisors/Committee Members: PERCIO AUGUSTO MARDINI FARIAS.

Subjects/Keywords: [pt] ZIDOVUDINA; [en] ZIDOVUDINE; [pt] VOLTAMETRIA; [en] VOLTAMMETRY; [pt] ANTIRETROVIRAIS; [en] ANTIRETROVIRAL; [pt] LAMIVUDINA; [en] LAMIVUDINE; [pt] ZALCITABINA; [en] ZALCITABINE

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

ANTUNES, K. C. L. (2004). [en] DEVELOPMENT OF ELECTROANALYTICALS METODOLOGY FOR DETERMINATION OF ZIDOVUDINE, LAMIVUDINE AND ZALCITABINE. (Thesis). Pontifical Catholic University of Rio de Janeiro. Retrieved from http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=5571

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

ANTUNES, KATIA CHRISTINA LEANDRO. “[en] DEVELOPMENT OF ELECTROANALYTICALS METODOLOGY FOR DETERMINATION OF ZIDOVUDINE, LAMIVUDINE AND ZALCITABINE.” 2004. Thesis, Pontifical Catholic University of Rio de Janeiro. Accessed April 15, 2021. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=5571.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

ANTUNES, KATIA CHRISTINA LEANDRO. “[en] DEVELOPMENT OF ELECTROANALYTICALS METODOLOGY FOR DETERMINATION OF ZIDOVUDINE, LAMIVUDINE AND ZALCITABINE.” 2004. Web. 15 Apr 2021.

Vancouver:

ANTUNES KCL. [en] DEVELOPMENT OF ELECTROANALYTICALS METODOLOGY FOR DETERMINATION OF ZIDOVUDINE, LAMIVUDINE AND ZALCITABINE. [Internet] [Thesis]. Pontifical Catholic University of Rio de Janeiro; 2004. [cited 2021 Apr 15]. Available from: http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=5571.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

ANTUNES KCL. [en] DEVELOPMENT OF ELECTROANALYTICALS METODOLOGY FOR DETERMINATION OF ZIDOVUDINE, LAMIVUDINE AND ZALCITABINE. [Thesis]. Pontifical Catholic University of Rio de Janeiro; 2004. Available from: http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=5571

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.