subject:(Yeast model)

University of California – San Francisco

1. Langer, Erika. Molecular Ferment: The Rise and Proliferation of Yeast Model Organism Research.

Degree: History of Health Sciences, 2016, University of California – San Francisco

URL: http://www.escholarship.org/uc/item/2g51w0qk

► This study examines the history of yeast hereditary research out of the fermentation industries and into the genetics laboratory, where a single-celled fungus underwent material,… (more)

Subjects/Keywords: Science history; History; Biology; Biomedicine; Genetics; Model; Molecular; Yeast

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APA (6^th Edition):

Langer, E. (2016). Molecular Ferment: The Rise and Proliferation of Yeast Model Organism Research. (Thesis). University of California – San Francisco. Retrieved from http://www.escholarship.org/uc/item/2g51w0qk

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Langer, Erika. “Molecular Ferment: The Rise and Proliferation of Yeast Model Organism Research.” 2016. Thesis, University of California – San Francisco. Accessed January 24, 2021. http://www.escholarship.org/uc/item/2g51w0qk.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Langer, Erika. “Molecular Ferment: The Rise and Proliferation of Yeast Model Organism Research.” 2016. Web. 24 Jan 2021.

Vancouver:

Langer E. Molecular Ferment: The Rise and Proliferation of Yeast Model Organism Research. [Internet] [Thesis]. University of California – San Francisco; 2016. [cited 2021 Jan 24]. Available from: http://www.escholarship.org/uc/item/2g51w0qk.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Langer E. Molecular Ferment: The Rise and Proliferation of Yeast Model Organism Research. [Thesis]. University of California – San Francisco; 2016. Available from: http://www.escholarship.org/uc/item/2g51w0qk

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Oxford

2. Freire, P. S. D. S. Mathematical modelling of mitotic exit control in budding yeast cell cycle.

Degree: PhD, 2012, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:982b3244-328d-4b76-b333-50287a753bc0 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.572498

► The operating principles of complex regulatory networks are more easily understood with mathematical modelling than by intuitive reasoning. In this thesis, I study the dynamics… (more)

▼ The operating principles of complex regulatory networks are more easily understood with mathematical modelling than by intuitive reasoning. In this thesis, I study the dynamics of the mitotic exit control system in budding yeast. I present a comprehensive mathematical model, which provides a system’s-level understanding of the mitotic exit process. This model captures the dynamics of classic experimental situations reported in the literature, and overcomes a number of limitations present in previous models. Analysis of the model led to a number of breakthroughs in the understanding of mitotic exit control. Firstly, numerical analysis of the model quantified the dependence of mitotic exit on the proteolytic and non-proteolytic functions of separase. It was shown that the requirement for the non-proteolytic function of separase depends on cyclin-dependent kinase activity. Secondly, APC/Cdc20 is a critical node that controls the phosphatase (Cdc14) branch and both cyclin (Clb2 and Clb5) branches of the cell cycle regulatory network. Thirdly, the model proved to be a useful tool for the systematic analysis of the recently discovered phenomenon of Cdc14 endocycles. Most proteins belonging to the cell cycle control network are regulated at the level of synthesis, degradation and activity. Presumably, these multiple layers of regulation facilitate robust cell cycle behaviour in the face of genetic and environmental perturbations. To falsify this hypothesis, I subjected the model to global parameter perturbations and tested viability against pre-defined criteria. According to these analyses, the regulated transcription and degradation of proteins make different contributions to cell cycle control. Regulated degradation confers cell cycle oscillations with robustness against perturbations, while regulated transcription plays a major role in controlling the period of these oscillations. Both regulated transcription and degradation are part of important feedback loops, that combined promote robust behaviour in the face of parametric variations.

Subjects/Keywords: 579.563015118; Biochemistry; cell cycle; budding yeast; mathematical model; mitotic exit

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APA (6^th Edition):

Freire, P. S. D. S. (2012). Mathematical modelling of mitotic exit control in budding yeast cell cycle. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:982b3244-328d-4b76-b333-50287a753bc0 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.572498

Chicago Manual of Style (16^th Edition):

Freire, P S D S. “Mathematical modelling of mitotic exit control in budding yeast cell cycle.” 2012. Doctoral Dissertation, University of Oxford. Accessed January 24, 2021. http://ora.ox.ac.uk/objects/uuid:982b3244-328d-4b76-b333-50287a753bc0 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.572498.

MLA Handbook (7^th Edition):

Freire, P S D S. “Mathematical modelling of mitotic exit control in budding yeast cell cycle.” 2012. Web. 24 Jan 2021.

Vancouver:

Freire PSDS. Mathematical modelling of mitotic exit control in budding yeast cell cycle. [Internet] [Doctoral dissertation]. University of Oxford; 2012. [cited 2021 Jan 24]. Available from: http://ora.ox.ac.uk/objects/uuid:982b3244-328d-4b76-b333-50287a753bc0 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.572498.

Council of Science Editors:

Freire PSDS. Mathematical modelling of mitotic exit control in budding yeast cell cycle. [Doctoral Dissertation]. University of Oxford; 2012. Available from: http://ora.ox.ac.uk/objects/uuid:982b3244-328d-4b76-b333-50287a753bc0 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.572498

University of Western Ontario

3. Tauro, Michael G. Alpha-Synuclein Toxicity is Caused by Mitochondrial Dysfunction.

Degree: 2019, University of Western Ontario

URL: https://ir.lib.uwo.ca/etd/6019

► Parkinson’s disease (PD) is the second most common neurodegenerative disorder, affecting roughly 1% of the population over the age of sixty years. Alpha-synuclein (aSyn) is… (more)

Subjects/Keywords: Parkinson's disease; alpha-synuclein; neurodegeneration; mitochondria; yeast model; Cell Biology

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APA (6^th Edition):

Tauro, M. G. (2019). Alpha-Synuclein Toxicity is Caused by Mitochondrial Dysfunction. (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/6019

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tauro, Michael G. “Alpha-Synuclein Toxicity is Caused by Mitochondrial Dysfunction.” 2019. Thesis, University of Western Ontario. Accessed January 24, 2021. https://ir.lib.uwo.ca/etd/6019.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tauro, Michael G. “Alpha-Synuclein Toxicity is Caused by Mitochondrial Dysfunction.” 2019. Web. 24 Jan 2021.

Vancouver:

Tauro MG. Alpha-Synuclein Toxicity is Caused by Mitochondrial Dysfunction. [Internet] [Thesis]. University of Western Ontario; 2019. [cited 2021 Jan 24]. Available from: https://ir.lib.uwo.ca/etd/6019.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tauro MG. Alpha-Synuclein Toxicity is Caused by Mitochondrial Dysfunction. [Thesis]. University of Western Ontario; 2019. Available from: https://ir.lib.uwo.ca/etd/6019

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Western Ontario

4. McCarton, Alexander S. Parkin Misfolding, Dysfunction, and Degradation in Parkinson's Disease.

Degree: 2016, University of Western Ontario

URL: https://ir.lib.uwo.ca/etd/3799

► Mutations in the gene encoding parkin (PARK2) result in familial early onset forms of Parkinson’s disease (PD) based on the loss of parkin’s E3 ubiquitin… (more)

Subjects/Keywords: Parkinson’s disease; parkin; oxidative stress; protein misfolding; aggregation; yeast model.; Biochemistry

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APA (6^th Edition):

McCarton, A. S. (2016). Parkin Misfolding, Dysfunction, and Degradation in Parkinson's Disease. (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/3799

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

McCarton, Alexander S. “Parkin Misfolding, Dysfunction, and Degradation in Parkinson's Disease.” 2016. Thesis, University of Western Ontario. Accessed January 24, 2021. https://ir.lib.uwo.ca/etd/3799.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

McCarton, Alexander S. “Parkin Misfolding, Dysfunction, and Degradation in Parkinson's Disease.” 2016. Web. 24 Jan 2021.

Vancouver:

McCarton AS. Parkin Misfolding, Dysfunction, and Degradation in Parkinson's Disease. [Internet] [Thesis]. University of Western Ontario; 2016. [cited 2021 Jan 24]. Available from: https://ir.lib.uwo.ca/etd/3799.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

McCarton AS. Parkin Misfolding, Dysfunction, and Degradation in Parkinson's Disease. [Thesis]. University of Western Ontario; 2016. Available from: https://ir.lib.uwo.ca/etd/3799

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Brandeis University

5. Liu, Bangyan. Identification of Bin1 Involvement in Tau Pathology Using a Yeast Model for Tauopathies.

Degree: 2016, Brandeis University

URL: http://hdl.handle.net/10192/32318

► Neurodegenerative diseases are devastating and incurable diseases that show a strong correlation to aging, posing great threats to both the population and the economy of… (more)

Subjects/Keywords: Alzheimer's Disease; Yeast Model; Tau Pathology; Genetic Screen; Bin1

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APA (6^th Edition):

Liu, B. (2016). Identification of Bin1 Involvement in Tau Pathology Using a Yeast Model for Tauopathies. (Thesis). Brandeis University. Retrieved from http://hdl.handle.net/10192/32318

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Liu, Bangyan. “Identification of Bin1 Involvement in Tau Pathology Using a Yeast Model for Tauopathies.” 2016. Thesis, Brandeis University. Accessed January 24, 2021. http://hdl.handle.net/10192/32318.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Liu, Bangyan. “Identification of Bin1 Involvement in Tau Pathology Using a Yeast Model for Tauopathies.” 2016. Web. 24 Jan 2021.

Vancouver:

Liu B. Identification of Bin1 Involvement in Tau Pathology Using a Yeast Model for Tauopathies. [Internet] [Thesis]. Brandeis University; 2016. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/10192/32318.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Liu B. Identification of Bin1 Involvement in Tau Pathology Using a Yeast Model for Tauopathies. [Thesis]. Brandeis University; 2016. Available from: http://hdl.handle.net/10192/32318

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Edinburgh

6. Walker, Roy Scott Kamla. De novo biological engineering of a tRNA neochromosome in yeast.

Degree: PhD, 2017, University of Edinburgh

URL: http://hdl.handle.net/1842/28921

► Advances in DNA synthesis technology have led to rapid growth in the field of synthetic biology, heralding a nascent era of synthetic genomics. Sc2.0 (Saccharomyces… (more)

▼ Advances in DNA synthesis technology have led to rapid growth in the field of synthetic biology, heralding a nascent era of synthetic genomics. Sc2.0 (Saccharomyces cerevisiae version 2.0) is an international consortium with the aim of designing and constructing a fully‐synthetic eukaryotic genome. Fundamental design changes to the synthetic genome include the removal of unstable tRNA genes and their intended collation onto a “tRNA neochromosome”, with the aim of producing a more robust and stable synthetic genome structure. To maintain viability of a synthetic yeast, the tRNA neochromosome is therefore considered an important if not essential aspect of this project. The application of engineering principles is synonymous with synthetic biology, regularly employing the recursive Design‐Build‐Test cycle to improve experimental approach. This doctoral study explores the design, construction and characterisation of a tRNA neochromosome in Saccharomyces cerevisiae. A series of design principles influenced by engineering concepts were used to rationalise the complexities of de novo chromosome engineering, maximise its stability and ensure function in vivo. A methodology based on in vivo homologous recombination was then developed and shown to reliably construct the neochromosome from its constituent parts. Experimental characterisation revealed that genetic elements function as expected, and that the parental strain can tolerate the sole presence of one each of three single‐copy, essential tRNA genes (SUP61, TRT2 and TRR4), although Northern blot revealed potential precursor accumulation of the SUP61 tRNA caused by the presence of a synthetic 5’ flanking sequence. Following the addition of synthetic telomere seed sequences, pulsed‐field gel electrophoresis (PFGE) and deep sequencing revealed complex structure variations in two independent strain backgrounds. Except for these structural variations, successful neochromosome construction demonstrated the applicability of the approaches used and the remarkable ability of the yeast model to support the presence of a 17th chromosome housing an additional 275 tRNA genes. The research in this thesis has for the first time described the design, construction and characterisation of a eukaryotic neochromosome de novo. It is hoped that the findings presented will further our understanding of tRNA biology and enhance the aims of the Sc2.0 project.

Subjects/Keywords: synthetic genomics; Saccharomyces cerevisiae; Sc2.0; tRNA neochromosome; yeast model

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Walker, R. S. K. (2017). De novo biological engineering of a tRNA neochromosome in yeast. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/28921

Chicago Manual of Style (16^th Edition):

Walker, Roy Scott Kamla. “De novo biological engineering of a tRNA neochromosome in yeast.” 2017. Doctoral Dissertation, University of Edinburgh. Accessed January 24, 2021. http://hdl.handle.net/1842/28921.

MLA Handbook (7^th Edition):

Walker, Roy Scott Kamla. “De novo biological engineering of a tRNA neochromosome in yeast.” 2017. Web. 24 Jan 2021.

Vancouver:

Walker RSK. De novo biological engineering of a tRNA neochromosome in yeast. [Internet] [Doctoral dissertation]. University of Edinburgh; 2017. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/1842/28921.

Council of Science Editors:

Walker RSK. De novo biological engineering of a tRNA neochromosome in yeast. [Doctoral Dissertation]. University of Edinburgh; 2017. Available from: http://hdl.handle.net/1842/28921

Wright State University

7. Cone, Alan J. Fission Yeast as a Model Organism for FUS-Dependent Cytotoxicity in Amyotrophic Lateral Sclerosis.

Degree: MS, Biological Sciences, 2016, Wright State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=wright1470750088

► Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative motor neuron disease that causes progressive paralysis and death by asphyxiation. There is no cure or effective treatment;… (more)

Subjects/Keywords: Cellular Biology; fus; fission yeast; pombe; ALS; amyotrophic; lateral; sclerosis; model; neurodegenerative; FTLD; frontotemporal lobar degeneration; yeast; Schizosaccharomyces

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cone, A. J. (2016). Fission Yeast as a Model Organism for FUS-Dependent Cytotoxicity in Amyotrophic Lateral Sclerosis. (Masters Thesis). Wright State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=wright1470750088

Chicago Manual of Style (16^th Edition):

Cone, Alan J. “Fission Yeast as a Model Organism for FUS-Dependent Cytotoxicity in Amyotrophic Lateral Sclerosis.” 2016. Masters Thesis, Wright State University. Accessed January 24, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=wright1470750088.

MLA Handbook (7^th Edition):

Cone, Alan J. “Fission Yeast as a Model Organism for FUS-Dependent Cytotoxicity in Amyotrophic Lateral Sclerosis.” 2016. Web. 24 Jan 2021.

Vancouver:

Cone AJ. Fission Yeast as a Model Organism for FUS-Dependent Cytotoxicity in Amyotrophic Lateral Sclerosis. [Internet] [Masters thesis]. Wright State University; 2016. [cited 2021 Jan 24]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=wright1470750088.

Council of Science Editors:

Cone AJ. Fission Yeast as a Model Organism for FUS-Dependent Cytotoxicity in Amyotrophic Lateral Sclerosis. [Masters Thesis]. Wright State University; 2016. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=wright1470750088

NSYSU

8. Jan, Yi-An. Model-Based Clustering for Gene Expression and Change Patterns.

Degree: Master, Applied Mathematics, 2011, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0729111-155816

► It is important to study gene expression and change patterns over a time period because biologically related gene groups are likely to share similar patterns.… (more)

Subjects/Keywords: Gene expression; Model-based clustering; Wavelet coefficients; Fourier coefficients; Yeast cell cycle data

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APA (6^th Edition):

Jan, Y. (2011). Model-Based Clustering for Gene Expression and Change Patterns. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0729111-155816

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jan, Yi-An. “Model-Based Clustering for Gene Expression and Change Patterns.” 2011. Thesis, NSYSU. Accessed January 24, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0729111-155816.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jan, Yi-An. “Model-Based Clustering for Gene Expression and Change Patterns.” 2011. Web. 24 Jan 2021.

Vancouver:

Jan Y. Model-Based Clustering for Gene Expression and Change Patterns. [Internet] [Thesis]. NSYSU; 2011. [cited 2021 Jan 24]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0729111-155816.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jan Y. Model-Based Clustering for Gene Expression and Change Patterns. [Thesis]. NSYSU; 2011. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0729111-155816

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Oulu

9. Tervasmäki, P. (Petri). Reaction and mass transfer kinetics in multiphase bioreactors:experimental and modelling studies.

Degree: 2018, University of Oulu

URL: http://urn.fi/urn:isbn:9789526220390

►

Abstract In the sugar platform of biorefining, the complex polymeric structure of lignocellulose biomass is degraded into sugars, which are utilized by microbial cells in… (more)

▼

Abstract In the sugar platform of biorefining, the complex polymeric structure of lignocellulose biomass is degraded into sugars, which are utilized by microbial cells in the further processing steps. The reaction steps in both biomass degradation and microbial fermentation processes involve multiphase reactions in which mass transfer and reaction kinetics often play a key role. The aim of this thesis is to characterize the effect of these conditions on enzymatic hydrolysis of cellulose and utilization of sugars by aerobic microbes. These types of liquid-solid (cellulose hydrolysis) and liquid-gas (microbial cultivation) systems are typically very demanding on the reactors that are used in the process. By the fed-batch process utilized in this work, sufficient mixing in enzymatic hydrolysis of cellulose is achieved even with high final substrate concentration. One of the main outcomes of this work is the kinetic model that concentrates on the kinetics of fed-batch process by discretizing the substrate into subpopulations. By using this approach, the model parameters were identified in an adequate manner, and the poorly identified parameters could be sorted out. Parameter identifiability has been an issue in previous models for enzymatic hydrolysis of cellulose. Based on the experiments and modelling studies, it can be concluded that the enzymes remain intact for time scales relevant for the hydrolysis process. Thus, the decrease in the hydrolysis rate found in many literature studies is probably mostly due to substrate-enzyme interactions rather than denaturation of the enzyme. In aerobic cell cultivations, the mixing and mass transfer conditions are often more critical for the process performance. In this work, we studied the performance and suitability of alternative reactor types to be used in aerobic cell cultivations and obtained some promising results. In addition, the thesis presents a modelling approach to study the effect of process conditions on metabolism and growth rate of Pichia pastoris yeast. The model combines a kinetic model for yeast growth and a model for the mixing and mass transfer conditions in stirred tank reactor.

Tiivistelmä Biojalostuksen sokerialustassa lignoselluloosapohjaisen biomassan monimutkaista polymeerirakennetta muokataan ja sieltä vapautetaan monomeerisia sokereita, joita voidaan edelleen hyödyntää jatkojalostuksessa. Monet jatkojalostusprosessit käyttävät mikrobeja, joiden aineenvaihdunnassa sokereita voidaan jalostaa arvokkaammiksi tuotteiksi ns. fermentointiprosesseissa. Tämän väitöstyön tarkoitus on tutkia reaktio- ja aineensiirtokinetiikan vaikutusta selluloosan entsymaattiseen hydrolyysiin ja aerobisiin mikrobifermentointeihin. Näistä ensimmäinen on neste-kiintoainesysteemi ja jälkimmäinen neste-kaasusysteemi, ja tällaiset prosessit asettavat tyypillisesti merkittäviä vaatimuksia niissä käytettäville reaktoreille. Tässä työssä hyödynnettiin kiinteän raaka-aineen vähittäistä syöttöä (ns. fed-batch prosessi) selluloosan hydrolyysissä, jolloin sekoitus voidaan pitää…

Advisors/Committee Members: Tanskanen, J. (Juha), Taskila, S. (Sanna), Ojamo, H. (Heikki).

Subjects/Keywords: bioreactor; cellulose; enzymatic hydrolysis; kinetic model; mass transfer; yeast; aineensiirto; bioreaktori; entsymaattinen hydrolyysi; hiiva; kineettinen malli; selluloosa

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tervasmäki, P. (. (2018). Reaction and mass transfer kinetics in multiphase bioreactors:experimental and modelling studies. (Doctoral Dissertation). University of Oulu. Retrieved from http://urn.fi/urn:isbn:9789526220390

Chicago Manual of Style (16^th Edition):

Tervasmäki, P (Petri). “Reaction and mass transfer kinetics in multiphase bioreactors:experimental and modelling studies.” 2018. Doctoral Dissertation, University of Oulu. Accessed January 24, 2021. http://urn.fi/urn:isbn:9789526220390.

MLA Handbook (7^th Edition):

Tervasmäki, P (Petri). “Reaction and mass transfer kinetics in multiphase bioreactors:experimental and modelling studies.” 2018. Web. 24 Jan 2021.

Vancouver:

Tervasmäki P(. Reaction and mass transfer kinetics in multiphase bioreactors:experimental and modelling studies. [Internet] [Doctoral dissertation]. University of Oulu; 2018. [cited 2021 Jan 24]. Available from: http://urn.fi/urn:isbn:9789526220390.

Council of Science Editors:

Tervasmäki P(. Reaction and mass transfer kinetics in multiphase bioreactors:experimental and modelling studies. [Doctoral Dissertation]. University of Oulu; 2018. Available from: http://urn.fi/urn:isbn:9789526220390

University of Cambridge

10. Fahmi, Zahra. Study of 3D Genome Organisation in Budding Yeast by Heterogeneous Polymer Simulations.

Degree: PhD, 2019, University of Cambridge

URL: https://www.repository.cam.ac.uk/handle/1810/287470https://www.repository.cam.ac.uk/bitstream/1810/287470/2/Vid.1-Fahmi.mov

► Investigating the arrangement of the packed DNA inside the nucleus has revealed the essential role of genome organisation in controlling genome function. Furthermore, genome architecture… (more)

▼ Investigating the arrangement of the packed DNA inside the nucleus has revealed the essential role of genome organisation in controlling genome function. Furthermore, genome architecture is highly dynamic and significant chromatin re-organisation occurs in response to environmental changes. However, the mechanisms that drive the 3D organisation of the genome remain largely unknown. To understand the effect of biophysical properties of chromatin on the dynamics and structure of chromosomes, I developed a 3D computational model of the nucleus of the yeast S. cerevisiae during interphase. In the model, each chromosome was a hetero-polymer informed by our bioinformatics analysis for heterogeneous occupancy of chromatin-associated proteins across the genome. Two different conditions were modelled, normal growth (25°C) and heat shock (37°C), where a concerted redistribution of proteins was observed upon transition from one temperature to the other. Movement of chromatin segments was based on Langevin dynamics and each segment had a mobility according to their protein occupancy and the expression level of their corresponding genes. The model provides a significantly improved match with quantitative microscopy measurements of telomere positions, the distributions of 3D distances between pairs of different loci, and the mean squared displacement of a labelled locus. The quantified contacts between chromosomal segments were similar to the observed Hi-C data. At both 25°C and 37°C conditions, the segments that were highly occupied by proteins had high number of interactions with each other, and the highly transcribed genes had lower contacts with other segments. In addition, similar to the experimental observations, heat-shock genes were found to be located closer to the nuclear periphery upon activation in the simulations. It was also shown that the determined distribution of proteins along the genome is crucial to achieve the correct genome organisation. Hence, the heterogeneous binding of proteins, which results in differential mobility of chromatin segments, leads to 3D self-organisation.

Subjects/Keywords: genome organisation; computational model; budding yeast; protein occupancy; chromatin mobility; temperature; Langevin force; self-organisation; normalisation; Hi-C data

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APA (6^th Edition):

Fahmi, Z. (2019). Study of 3D Genome Organisation in Budding Yeast by Heterogeneous Polymer Simulations. (Doctoral Dissertation). University of Cambridge. Retrieved from https://www.repository.cam.ac.uk/handle/1810/287470https://www.repository.cam.ac.uk/bitstream/1810/287470/2/Vid.1-Fahmi.mov

Chicago Manual of Style (16^th Edition):

Fahmi, Zahra. “Study of 3D Genome Organisation in Budding Yeast by Heterogeneous Polymer Simulations.” 2019. Doctoral Dissertation, University of Cambridge. Accessed January 24, 2021. https://www.repository.cam.ac.uk/handle/1810/287470https://www.repository.cam.ac.uk/bitstream/1810/287470/2/Vid.1-Fahmi.mov.

MLA Handbook (7^th Edition):

Fahmi, Zahra. “Study of 3D Genome Organisation in Budding Yeast by Heterogeneous Polymer Simulations.” 2019. Web. 24 Jan 2021.

Vancouver:

Fahmi Z. Study of 3D Genome Organisation in Budding Yeast by Heterogeneous Polymer Simulations. [Internet] [Doctoral dissertation]. University of Cambridge; 2019. [cited 2021 Jan 24]. Available from: https://www.repository.cam.ac.uk/handle/1810/287470https://www.repository.cam.ac.uk/bitstream/1810/287470/2/Vid.1-Fahmi.mov.

Council of Science Editors:

Fahmi Z. Study of 3D Genome Organisation in Budding Yeast by Heterogeneous Polymer Simulations. [Doctoral Dissertation]. University of Cambridge; 2019. Available from: https://www.repository.cam.ac.uk/handle/1810/287470https://www.repository.cam.ac.uk/bitstream/1810/287470/2/Vid.1-Fahmi.mov

Delft University of Technology

11. Kresnowati, M.T.A.P. Stimulus response methodology for quantitative model development of central carbon metabolism in Saccharomyces cerevisiae.

Degree: 2007, Delft University of Technology

URL: http://resolver.tudelft.nl/uuid:65b71542-b0d1-4c45-a24b-6391379ce453 ; urn:NBN:nl:ui:24-uuid:65b71542-b0d1-4c45-a24b-6391379ce453 ; urn:NBN:nl:ui:24-uuid:65b71542-b0d1-4c45-a24b-6391379ce453 ; http://resolver.tudelft.nl/uuid:65b71542-b0d1-4c45-a24b-6391379ce453

Abstract not available Advisors/Committee Members: Heijnen, J.J..

Subjects/Keywords: stimulus response; yeast; central carbon metabolism; model; dynamic

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APA (6^th Edition):

Kresnowati, M. T. A. P. (2007). Stimulus response methodology for quantitative model development of central carbon metabolism in Saccharomyces cerevisiae. (Doctoral Dissertation). Delft University of Technology. Retrieved from http://resolver.tudelft.nl/uuid:65b71542-b0d1-4c45-a24b-6391379ce453 ; urn:NBN:nl:ui:24-uuid:65b71542-b0d1-4c45-a24b-6391379ce453 ; urn:NBN:nl:ui:24-uuid:65b71542-b0d1-4c45-a24b-6391379ce453 ; http://resolver.tudelft.nl/uuid:65b71542-b0d1-4c45-a24b-6391379ce453

Chicago Manual of Style (16^th Edition):

Kresnowati, M T A P. “Stimulus response methodology for quantitative model development of central carbon metabolism in Saccharomyces cerevisiae.” 2007. Doctoral Dissertation, Delft University of Technology. Accessed January 24, 2021. http://resolver.tudelft.nl/uuid:65b71542-b0d1-4c45-a24b-6391379ce453 ; urn:NBN:nl:ui:24-uuid:65b71542-b0d1-4c45-a24b-6391379ce453 ; urn:NBN:nl:ui:24-uuid:65b71542-b0d1-4c45-a24b-6391379ce453 ; http://resolver.tudelft.nl/uuid:65b71542-b0d1-4c45-a24b-6391379ce453.

MLA Handbook (7^th Edition):

Kresnowati, M T A P. “Stimulus response methodology for quantitative model development of central carbon metabolism in Saccharomyces cerevisiae.” 2007. Web. 24 Jan 2021.

Vancouver:

Kresnowati MTAP. Stimulus response methodology for quantitative model development of central carbon metabolism in Saccharomyces cerevisiae. [Internet] [Doctoral dissertation]. Delft University of Technology; 2007. [cited 2021 Jan 24]. Available from: http://resolver.tudelft.nl/uuid:65b71542-b0d1-4c45-a24b-6391379ce453 ; urn:NBN:nl:ui:24-uuid:65b71542-b0d1-4c45-a24b-6391379ce453 ; urn:NBN:nl:ui:24-uuid:65b71542-b0d1-4c45-a24b-6391379ce453 ; http://resolver.tudelft.nl/uuid:65b71542-b0d1-4c45-a24b-6391379ce453.

Council of Science Editors:

Kresnowati MTAP. Stimulus response methodology for quantitative model development of central carbon metabolism in Saccharomyces cerevisiae. [Doctoral Dissertation]. Delft University of Technology; 2007. Available from: http://resolver.tudelft.nl/uuid:65b71542-b0d1-4c45-a24b-6391379ce453 ; urn:NBN:nl:ui:24-uuid:65b71542-b0d1-4c45-a24b-6391379ce453 ; urn:NBN:nl:ui:24-uuid:65b71542-b0d1-4c45-a24b-6391379ce453 ; http://resolver.tudelft.nl/uuid:65b71542-b0d1-4c45-a24b-6391379ce453

University of Southern California

12. Ge, Huanying. Statistical analysis of microarray data and functional genomics of yeast ageing.

Degree: PhD, Computational Biology & Bioinformatics, 2009, University of Southern California

URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/236659/rec/6048

► This dissertation focuses on the computational biology researches using Affymetrix microarray technology. It consists of two parts, focusing on two different levels of statistical analysis… (more)

▼ This dissertation focuses on the computational biology researches using Affymetrix microarray technology. It consists of two parts, focusing on two different levels of statistical analysis of microarray data.; In the first part, I describe the proposed Probe-Treatment-Reference (PTR) model, which can streamline normalization and summarization. Normalization aims to remove non-biological variations across different arrays. The normalization algorithms generally require the specification of reference and target arrays. However, the issue of reference selection has not been fully addressed. Summarization aims to estimate the transcript abundance from normalized intensities. In the PTR method, we considered normalization and summarization jointly by a new strategy of reference selection. It is a general framework to deal with the issue of reference selection and can readily be applied to existing normalization algorithms such as the invariant-set, sub-array and quantile method. In the PTR summarization, we estimate parameters in the model by the Least Absolute Deviations (LAD) approach and implement the computation by median polishing. I will show that the LAD estimator is robust in the sense that it has bounded influence in the three-factor PTR model. This model fitting, implicitly, defines an "optimal reference" for each probe-set. I evaluated the effectiveness of the PTR method by two Affymetrix spike-in data sets. Our method reduces the variations of non-differentially expressed genes and thereby increases the detection power of differentially expressed genes. This microarray pre-processing method provided a solid basis for our later investigation of gene expression.; In the second part, I describe our comparative analyses of gene expression profiles of the long-lived yeast sch9Δ mutant and the wild type. The yeast sch9Δ mutant has a smaller cell size and lives three times as long as the wild type chronologically. In order to investigate the changes of biological activities and pathways that account for the longevity extension, we measured their gene expression profiles every 12 hours from 12 to 120 hours in the synthetic dextrose complete medium. We processed the microarray data based on the PTR model, in which pairwise sub-array normalization was first implemented and then the normalized arrays were summarized into expression values for each probe-set and each sample. We compared the expression profiles and time difference profiles between the two strains and interpret them by statistical inferences based on biological knowledge including Gene Ontology, KEGG pathway, and protein localization data. The results implied that the sch9Δ mutant followed a different metabolic path during the chronological ageing as indicated by two observations: (i) mitochondrial ribosome genes were not up-regulated in the sch9Δ mutant as in the wild type after diauxic-shift; (ii) electron transport, oxidative phosphorylation and TCA were down-regulated earlier. In addition, between 12 and 24 hours, we observed the following in the sch9Δ… Advisors/Committee Members: Li, Lei M. (Committee Chair), Sun, Fengzhu Z. (Committee Member), Longo, Valter D. (Committee Member), James, Gareth (Committee Member).

Subjects/Keywords: microarray; summarization model; outlier probe; yeast ageing; longevity; SCH9

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APA (6^th Edition):

Ge, H. (2009). Statistical analysis of microarray data and functional genomics of yeast ageing. (Doctoral Dissertation). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/236659/rec/6048

Chicago Manual of Style (16^th Edition):

Ge, Huanying. “Statistical analysis of microarray data and functional genomics of yeast ageing.” 2009. Doctoral Dissertation, University of Southern California. Accessed January 24, 2021. http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/236659/rec/6048.

MLA Handbook (7^th Edition):

Ge, Huanying. “Statistical analysis of microarray data and functional genomics of yeast ageing.” 2009. Web. 24 Jan 2021.

Vancouver:

Ge H. Statistical analysis of microarray data and functional genomics of yeast ageing. [Internet] [Doctoral dissertation]. University of Southern California; 2009. [cited 2021 Jan 24]. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/236659/rec/6048.

Council of Science Editors:

Ge H. Statistical analysis of microarray data and functional genomics of yeast ageing. [Doctoral Dissertation]. University of Southern California; 2009. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/236659/rec/6048

University of South Carolina

13. Collins, Kirsten Renee. Investigating The Effects of Glutathione and Other Key Proteins on Iron Homeostasis and Subcellular Redox Balance in Yeast Model Systems.

Degree: MS, Chemistry and Biochemistry, 2016, University of South Carolina

URL: https://scholarcommons.sc.edu/etd/3965

► Iron homeostasis in Saccharomyces cerevisiae is controlled through several pathways and is important because too much iron can cause cellular damage. Iron homeostasis in… (more)

▼ Iron homeostasis in Saccharomyces cerevisiae is controlled through several pathways and is important because too much iron can cause cellular damage. Iron homeostasis in yeast is primarily controlled by transcription factors Aft1 and Aft2 which bind to the iron regulon to induce iron uptake when iron levels are low. When iron levels are sufficient, Aft1 and Aft2 are bound and inhibited by monothiol glutaredoxins (Grxs) Grx3 and Grx4. These Grxs are also involved in iron trafficking in the cell and bind to and deliver iron-sulfur clusters to multiple proteins. The first part of this thesis focuses on determining if excess GSH/GSSG disrupts iron trafficking in grx3 grx4 mutant strains (grx3Δgrx4Δ) and (grx3Δ Gal-GRX4). Total and oxidized glutathione were increased in Δgrx3Δgrx4 compared to wild type (WT). Total and oxidized glutathione was higher in Δgrx3 Gal-GRX4 than WT 40 hours after galactose removal, but by 64 hours a suppressor mutation developed and glutathione levels resembled those of WT. Δgrx4 Gal-GRX3 had the same issue. The increased glutathione previously observed in literature were not able to be replicated. Experiments of expression levels of GSH1 were inconclusive. The second part of this thesis looks at iron homeostasis in budding yeast Saccharomyces cerevisiae and fission yeast Schizosaccharomyces pombe. These species utilize homologous proteins as well as proteins unique to each species. In S. pombe, glutaredoxin, Grx4, interacts with and regulates the iron-dependent transcriptional repressor Php4. Similar to its homologues, Grx4 forms a [2Fe-2S]-bridged homodimer alone, and a [2Fe-2S]-bridged heterocomplex when co-expressed with Php4. When iron is sufficient, Grx4 interacts with Php4 to form a [2Fe-2S] cluster-bound complex, communicating cellular iron status and inhibiting Php4 activity. Fra2 was often insoluble and unstable. Coexpressing Fra2 with Pphp4 or Grx4 did not improve the stability. A urea extraction of Fra2 expressed independently improved solubility but Fra2 was still unstable. Fra2 coexpressed with the Takara chaperones did not improve the solubility. The third portion of this thesis involves glutathione reducing reactive oxygen species (ROS) and maintaining redox balance within the cell. A rxYFP sensor was targeted to the mitochondrial intermembrane space (IMS) in order to measure the redox status of this subcellular compartment when the cell was exposed to oxidative stress. The hope for this work is to answer questions about the redox states and mechanisms controlling redox homeostasis on the subcellular level. The rxYFP sensor in the HGT1 overexpression strain as well as in the empty vector control was much more reduced than previously observed. Troubleshooting experiments were unable to resolve this issue. Advisors/Committee Members: Caryn E. Outten.

Subjects/Keywords: Chemistry; Physical Sciences and Mathematics; Investigating The Effects of Glutathione; Key Proteins on Iron Homeostasis; Subcellular Redox Balance; Yeast Model Systems

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APA (6^th Edition):

Collins, K. R. (2016). Investigating The Effects of Glutathione and Other Key Proteins on Iron Homeostasis and Subcellular Redox Balance in Yeast Model Systems. (Masters Thesis). University of South Carolina. Retrieved from https://scholarcommons.sc.edu/etd/3965

Chicago Manual of Style (16^th Edition):

Collins, Kirsten Renee. “Investigating The Effects of Glutathione and Other Key Proteins on Iron Homeostasis and Subcellular Redox Balance in Yeast Model Systems.” 2016. Masters Thesis, University of South Carolina. Accessed January 24, 2021. https://scholarcommons.sc.edu/etd/3965.

MLA Handbook (7^th Edition):

Collins, Kirsten Renee. “Investigating The Effects of Glutathione and Other Key Proteins on Iron Homeostasis and Subcellular Redox Balance in Yeast Model Systems.” 2016. Web. 24 Jan 2021.

Vancouver:

Collins KR. Investigating The Effects of Glutathione and Other Key Proteins on Iron Homeostasis and Subcellular Redox Balance in Yeast Model Systems. [Internet] [Masters thesis]. University of South Carolina; 2016. [cited 2021 Jan 24]. Available from: https://scholarcommons.sc.edu/etd/3965.

Council of Science Editors:

Collins KR. Investigating The Effects of Glutathione and Other Key Proteins on Iron Homeostasis and Subcellular Redox Balance in Yeast Model Systems. [Masters Thesis]. University of South Carolina; 2016. Available from: https://scholarcommons.sc.edu/etd/3965

14. Petrizzelli, Marianyela. Mathematical modelling and integration of complex biological data : analysis of the heterosis phenomenon in yeast : Modélisation mathématique et intégration de données biologiques complexes : analyse du phénomène d’hétérosis chez la levure.

Degree: Docteur es, Sciences de la vie et de la santé, 2019, Université Paris-Saclay (ComUE)

URL: http://www.theses.fr/2019SACLS204

►

Le cadre général de cette thèse est la question de la relation génotype-phénotype, abordée à travers l'analyse du phénomène d'hétérosis chez la levure, dans une… (more)

▼

Le cadre général de cette thèse est la question de la relation génotype-phénotype, abordée à travers l'analyse du phénomène d'hétérosis chez la levure, dans une approche associant biologie, mathématiques et statistiques. Antérieurement à ce travail, un très gros jeu de données hétérogènes, correspondant à différents niveaux d'organisation (protéomique, caractères de fermentation et traits d'histoire de vie), avait été recueilli sur un dispositif demi-diallèle entre 11 souches appartenant à deux espèces. Ce type de données est idéalement adapté pour la modélisation multi-échelle et pour tester des modèles de prédiction de la variation de phénotypes intégrés à partir de caractères protéiques et métaboliques (flux), tout en tenant compte des structures de dépendance entre variables et entre observations. J’ai d'abord décomposé, pour chaque caractère, la variance génétique totale en variances des effets additifs, de consanguinité et d'hétérosis, et j’ai montré que la distribution de ces composantes permettait de définir des groupes bien tranchés de protéines dans lesquels se plaçaient la plupart des caractères de fermentation et de traits d'histoire de vie. Au sein de ces groupes, les corrélations entre les variances des effets d'hétérosis et de consanguinité pouvaient être positives, négatives ou nulles, ce qui a constitué la première mise en évidence expérimentale d’un découplage possible entre les deux phénomènes. Le second volet de la thèse a consisté à interfacer les données de protéomique quantitative avec un modèle stœchiométrique du métabolisme carboné central de la levure, en utilisant une approche de modélisation à base de contraintes. M'appuyant sur un algorithme récent, j’ai cherché, dans l'espace des solutions possibles, celle qui minimisait la distance entre le vecteur de flux et le vecteur des abondances observées des protéines. J’ai ainsi pu prédire un ensemble de flux et comparer les patrons de corrélations entre caractères à plusieurs niveaux d'intégration. Les données révèlent deux grandes familles de caractères de fermentation ou de traits d'histoire de vie dont l'interprétation biochimique est cohérente en termes de trade-off, et qui n'avaient pas été mises en évidence à partir des seules données de protéomique quantitative. L'ensemble de mes travaux permet de mieux comprendre l'évolution de la relation entre génotype et phénotype.

The general framework of this thesis is the issue of the genotype-phenotype relationship, through the analysis of the heterosis phenomenon in yeast, in an approach combining biology, mathematics and statistics. Prior to this work, a very large set of heterogeneous data, corresponding to different levels of organization (proteomics, fermentation and life history traits), had been collected on a semi-diallel design involving 11 strains belonging to two species. This type of data is ideally suited for multi-scale modelling and for testing models for predicting the variation of integrated phenotypes from protein and metabolic (flux) traits, taking into account dependence…

Advisors/Committee Members: Vienne, Dominique de (thesis director), Dillmann, Christine (thesis director).

Subjects/Keywords: Vigueur hybride; Consanguinité; Dispositif diallèle; Intégration des données; Métabolisme; Levure; Hybrid vigor; Inbreeding; Diallel design; Constraint-Based model; Metabolism; Yeast

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APA (6^th Edition):

Petrizzelli, M. (2019). Mathematical modelling and integration of complex biological data : analysis of the heterosis phenomenon in yeast : Modélisation mathématique et intégration de données biologiques complexes : analyse du phénomène d’hétérosis chez la levure. (Doctoral Dissertation). Université Paris-Saclay (ComUE). Retrieved from http://www.theses.fr/2019SACLS204

Chicago Manual of Style (16^th Edition):

Petrizzelli, Marianyela. “Mathematical modelling and integration of complex biological data : analysis of the heterosis phenomenon in yeast : Modélisation mathématique et intégration de données biologiques complexes : analyse du phénomène d’hétérosis chez la levure.” 2019. Doctoral Dissertation, Université Paris-Saclay (ComUE). Accessed January 24, 2021. http://www.theses.fr/2019SACLS204.

MLA Handbook (7^th Edition):

Petrizzelli, Marianyela. “Mathematical modelling and integration of complex biological data : analysis of the heterosis phenomenon in yeast : Modélisation mathématique et intégration de données biologiques complexes : analyse du phénomène d’hétérosis chez la levure.” 2019. Web. 24 Jan 2021.

Vancouver:

Petrizzelli M. Mathematical modelling and integration of complex biological data : analysis of the heterosis phenomenon in yeast : Modélisation mathématique et intégration de données biologiques complexes : analyse du phénomène d’hétérosis chez la levure. [Internet] [Doctoral dissertation]. Université Paris-Saclay (ComUE); 2019. [cited 2021 Jan 24]. Available from: http://www.theses.fr/2019SACLS204.

Council of Science Editors:

Petrizzelli M. Mathematical modelling and integration of complex biological data : analysis of the heterosis phenomenon in yeast : Modélisation mathématique et intégration de données biologiques complexes : analyse du phénomène d’hétérosis chez la levure. [Doctoral Dissertation]. Université Paris-Saclay (ComUE); 2019. Available from: http://www.theses.fr/2019SACLS204

15. Cui, Jing. Visualization of the Budding Yeast Cell Cycle.

Degree: MS, Computer Science and Applications, 2017, Virginia Tech

URL: http://hdl.handle.net/10919/78815

► The cell cycle of budding yeast is controlled by a complex chemically reacting network. Many mathematical models have been proposed to unravel its molecular mechanism.… (more)

Subjects/Keywords: Budding yeast cell cycle; Deterministic model; MUTANTS; HYBRID MODEL; VISUALIZATION

…5 2.2 Consensus model of the regulatory network in the budding yeast. . . . . . . 6… …raised upon a mathematical model of the budding yeast cell cycle. For example, how good is a… …Chapter 3. Modeling the Budding Yeast Cell Cycle Control Mechanism 9 model to its stochastic… …deterministic model can only capture the average behavior of the budding yeast cells. The fluctuations… …x5D; presented a hybrid (ODE/SSA) stochastic model of the budding yeast cell cycle…

10 more images…

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APA (6^th Edition):

Cui, J. (2017). Visualization of the Budding Yeast Cell Cycle. (Masters Thesis). Virginia Tech. Retrieved from http://hdl.handle.net/10919/78815

Chicago Manual of Style (16^th Edition):

Cui, Jing. “Visualization of the Budding Yeast Cell Cycle.” 2017. Masters Thesis, Virginia Tech. Accessed January 24, 2021. http://hdl.handle.net/10919/78815.

MLA Handbook (7^th Edition):

Cui, Jing. “Visualization of the Budding Yeast Cell Cycle.” 2017. Web. 24 Jan 2021.

Vancouver:

Cui J. Visualization of the Budding Yeast Cell Cycle. [Internet] [Masters thesis]. Virginia Tech; 2017. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/10919/78815.

Council of Science Editors:

Cui J. Visualization of the Budding Yeast Cell Cycle. [Masters Thesis]. Virginia Tech; 2017. Available from: http://hdl.handle.net/10919/78815

University of Sydney

16. Soltani, Behdad. Model Based Quality Prediction in Fluidised-Bed Dryers for Yeast .

Degree: University of Sydney

URL: http://hdl.handle.net/2123/21373

► The key aims of this work were to 1) develop a numerical model that would be capable of predicting fluidised-bed dryer operating parameters (including bed… (more)

Subjects/Keywords: Fluidised-bed dryer; Lumoed modelling; Yeast drying; Response surface model; Yeast Viability; Flow cytometry

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APA (6^th Edition):

Soltani, B. (n.d.). Model Based Quality Prediction in Fluidised-Bed Dryers for Yeast . (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/21373

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Soltani, Behdad. “Model Based Quality Prediction in Fluidised-Bed Dryers for Yeast .” Thesis, University of Sydney. Accessed January 24, 2021. http://hdl.handle.net/2123/21373.

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Soltani, Behdad. “Model Based Quality Prediction in Fluidised-Bed Dryers for Yeast .” Web. 24 Jan 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Soltani B. Model Based Quality Prediction in Fluidised-Bed Dryers for Yeast . [Internet] [Thesis]. University of Sydney; [cited 2021 Jan 24]. Available from: http://hdl.handle.net/2123/21373.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

Soltani B. Model Based Quality Prediction in Fluidised-Bed Dryers for Yeast . [Thesis]. University of Sydney; Available from: http://hdl.handle.net/2123/21373

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

17. Bannon, Amber. Translating Genetic Data into Actionable Clinical Guidelines: Succinate Dehydrogenase Subunit A Variants of Unknown Significance in Gastrointestinal Stromal Tumors.

Degree: PhD, 2017, Oregon Health Sciences University

URL: doi:10.6083/M49K49RK ; http://digitalcommons.ohsu.edu/etd/3972

Subjects/Keywords: Cancer biology; Yeast model; GIST; SDH; Medicine and Health Sciences

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APA (6^th Edition):

Bannon, A. (2017). Translating Genetic Data into Actionable Clinical Guidelines: Succinate Dehydrogenase Subunit A Variants of Unknown Significance in Gastrointestinal Stromal Tumors. (Doctoral Dissertation). Oregon Health Sciences University. Retrieved from doi:10.6083/M49K49RK ; http://digitalcommons.ohsu.edu/etd/3972

Chicago Manual of Style (16^th Edition):

Bannon, Amber. “Translating Genetic Data into Actionable Clinical Guidelines: Succinate Dehydrogenase Subunit A Variants of Unknown Significance in Gastrointestinal Stromal Tumors.” 2017. Doctoral Dissertation, Oregon Health Sciences University. Accessed January 24, 2021. doi:10.6083/M49K49RK ; http://digitalcommons.ohsu.edu/etd/3972.

MLA Handbook (7^th Edition):

Bannon, Amber. “Translating Genetic Data into Actionable Clinical Guidelines: Succinate Dehydrogenase Subunit A Variants of Unknown Significance in Gastrointestinal Stromal Tumors.” 2017. Web. 24 Jan 2021.

Vancouver:

Bannon A. Translating Genetic Data into Actionable Clinical Guidelines: Succinate Dehydrogenase Subunit A Variants of Unknown Significance in Gastrointestinal Stromal Tumors. [Internet] [Doctoral dissertation]. Oregon Health Sciences University; 2017. [cited 2021 Jan 24]. Available from: doi:10.6083/M49K49RK ; http://digitalcommons.ohsu.edu/etd/3972.

Council of Science Editors:

Bannon A. Translating Genetic Data into Actionable Clinical Guidelines: Succinate Dehydrogenase Subunit A Variants of Unknown Significance in Gastrointestinal Stromal Tumors. [Doctoral Dissertation]. Oregon Health Sciences University; 2017. Available from: doi:10.6083/M49K49RK ; http://digitalcommons.ohsu.edu/etd/3972

Lincoln University

18. Haslett, Nicholas D. Development of a eukaryotic microbial fuel cell using Arxula adeninivorans.

Degree: 2012, Lincoln University

URL: http://hdl.handle.net/10182/4783

► The bulk of microbial fuel cell work has been conducted on prokaryotic microorganisms, with eukaryotes considered too sluggish. Access to the electron transport chain in… (more)

Subjects/Keywords: MFC; Arxula adeninivorans; Saccharomyces cerevisiae; AFRE2; microbial fuel cell; yeast; eukaryote; electrochemistry; biochemistry; microbiology; osmium polymers; mediators; transformation; power density; model; internal resistance; cyclic voltammetry; Pseudomonas aerugenosa

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APA (6^th Edition):

Haslett, N. D. (2012). Development of a eukaryotic microbial fuel cell using Arxula adeninivorans. (Thesis). Lincoln University. Retrieved from http://hdl.handle.net/10182/4783

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Haslett, Nicholas D. “Development of a eukaryotic microbial fuel cell using Arxula adeninivorans.” 2012. Thesis, Lincoln University. Accessed January 24, 2021. http://hdl.handle.net/10182/4783.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Haslett, Nicholas D. “Development of a eukaryotic microbial fuel cell using Arxula adeninivorans.” 2012. Web. 24 Jan 2021.

Vancouver:

Haslett ND. Development of a eukaryotic microbial fuel cell using Arxula adeninivorans. [Internet] [Thesis]. Lincoln University; 2012. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/10182/4783.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Haslett ND. Development of a eukaryotic microbial fuel cell using Arxula adeninivorans. [Thesis]. Lincoln University; 2012. Available from: http://hdl.handle.net/10182/4783

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Jawaharlal Nehru University

19. Raghavan, Vineetha. Developing a yeast model of IMYMV DNA genome replication to understand the replication processes and roles of the replication factors in a facile manner;.

Degree: International Centre for Genetic Engineering and Biotechnology, 2004, Jawaharlal Nehru University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/16432

none

Bibliography p.121-141,illustration page no.is not given.

Advisors/Committee Members: Mukherjee, K.Sunil.

Subjects/Keywords: replication factors in a facile manner; replication processes; yeast model; genome replication

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APA (6^th Edition):

Raghavan, V. (2004). Developing a yeast model of IMYMV DNA genome replication to understand the replication processes and roles of the replication factors in a facile manner;. (Thesis). Jawaharlal Nehru University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/16432

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Raghavan, Vineetha. “Developing a yeast model of IMYMV DNA genome replication to understand the replication processes and roles of the replication factors in a facile manner;.” 2004. Thesis, Jawaharlal Nehru University. Accessed January 24, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/16432.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Raghavan, Vineetha. “Developing a yeast model of IMYMV DNA genome replication to understand the replication processes and roles of the replication factors in a facile manner;.” 2004. Web. 24 Jan 2021.

Vancouver:

Raghavan V. Developing a yeast model of IMYMV DNA genome replication to understand the replication processes and roles of the replication factors in a facile manner;. [Internet] [Thesis]. Jawaharlal Nehru University; 2004. [cited 2021 Jan 24]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/16432.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Raghavan V. Developing a yeast model of IMYMV DNA genome replication to understand the replication processes and roles of the replication factors in a facile manner;. [Thesis]. Jawaharlal Nehru University; 2004. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/16432

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Penn State University

20. Chowdhury, Anupam. Developing optimization-based algorithms for rational engineering of microbial strains.

Degree: 2016, Penn State University

URL: https://submit-etda.libraries.psu.edu/catalog/13325axc1028

► Concerns regarding crude oil depletion and climate change have encouraged the development of renewable biochemicals and biofuels using carbohydrates as the feedstock. With increased familiarity… (more)

▼ Concerns regarding crude oil depletion and climate change have encouraged the development of renewable biochemicals and biofuels using carbohydrates as the feedstock. With increased familiarity of microbial metabolism and ever-accelerating pace of genome sequencing and annotation, the ease of genetic manipulation for accomplishing biotechnological objectives have rapidly matured from single gene manipulations to genome-wide perturbations and tunable control of pathways. Development in experimental practices has been concurrently supported with novel computational techniques aimed towards accurate a priori prediction of cellular behavior towards genetic manipulations. Complete understanding of chemical repertoire of microorganisms requires cataloguing their enzyme-catalyzed reactions, synthesized molecules along with their individual capabilities through construction of their genome-scale metabolic networks. De novo metabolic pathways can be carefully designed to outperform native pathways with higher carbon and energy efficiencies as well as expand the product range of a host organism. However, scanning through the huge repertoire of microbial enzymes to identify potential components of a novel pathway is a challenging task as one has to consider all the possible factors affecting the pathway efficiency. They include the stoichiometric and cofactor balance, thermodynamic feasibility, co-substrate and co-product choices and compatibility of the enzymes with the host. To this end, we have developed a two-stage (optStoic and minRxn/minFlux) optimization formalism. The first step, optStoic, explores the maximum extent of converting carbon substrate(s) to desired product(s) through non-intuitive combination of co-reactants and co-products while remaining within the limits of mass, energy and thermodynamic balances. Subsequently, minRxn/minFlux identifies a minimal reaction network to achieve the overall conversion. Identified designs consisted of improvement on existing strategies in terms of both carbon and energy efficiency. Specifically, multiple alternatives for non-oxidative glycolysis and methanotrophy were identified that showed non-intuitive combinations of a core set of known pathways can lead to higher carbon and energy efficiency. Once the designed pathway is introduced in the host strain, the metabolic fluxes need to be re-apportioned towards the target product. Several optimization-based computational techniques have been developed to achieve this aim, including the OptForce algorithm, which was implemented to engineer E. coli for overproduction of medium-chain fatty acids in a novel integrated experimental and computational approach. However, we noted that existing strain-design approaches overlook the effects of metabolite concentrations and substrate-level enzyme regulation while identifying metabolic interventions. We addressed this issue by introducing k-OptForce, which integrates the available kinetic descriptions of metabolic steps with stoichiometric models to sharpen the prediction of intervention… Advisors/Committee Members: Costas D. Maranas, Dissertation Advisor/Co-Advisor, Costas D Maranas, Committee Chair/Co-Chair, Manish Kumar, Committee Member, Ali Borhan, Committee Member, Cooduvalli S Shashikant, Outside Member.

Subjects/Keywords: computational bioengineering; genome-scale metabolic model; strain-design algorithms; deterministic optimization protocols; kinetic models of metabolism; metabolic pathway prediction; metabolic engineering e coli & yeast

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chowdhury, A. (2016). Developing optimization-based algorithms for rational engineering of microbial strains. (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/13325axc1028

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chowdhury, Anupam. “Developing optimization-based algorithms for rational engineering of microbial strains.” 2016. Thesis, Penn State University. Accessed January 24, 2021. https://submit-etda.libraries.psu.edu/catalog/13325axc1028.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chowdhury, Anupam. “Developing optimization-based algorithms for rational engineering of microbial strains.” 2016. Web. 24 Jan 2021.

Vancouver:

Chowdhury A. Developing optimization-based algorithms for rational engineering of microbial strains. [Internet] [Thesis]. Penn State University; 2016. [cited 2021 Jan 24]. Available from: https://submit-etda.libraries.psu.edu/catalog/13325axc1028.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chowdhury A. Developing optimization-based algorithms for rational engineering of microbial strains. [Thesis]. Penn State University; 2016. Available from: https://submit-etda.libraries.psu.edu/catalog/13325axc1028

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

21. Song, Zehua. Agents antimicrobiens ciblant le complexe III de la chaine respiratoire mitochondriale : Etudes des déterminants structuraux de la sensibilité différentielle et du développement de la résistance, en utilisant la levure comme organisme modèle : Anti-microbial agents targeting complex III of the mitochondrial respiratory chain : Studying the structural determinants of differential sensitivity and the development of resistance, using yeast as a model organism.

Degree: Docteur es, Sciences de la vie et de la santé, 2016, Université Paris-Saclay (ComUE)

URL: http://www.theses.fr/2016SACLS281

►

Le complexe bc₁ de la chaîne respiratoire mitochondriale est une bonne cible thérapeutique pour traiter le paludisme car cette enzyme est essentielle au parasite. Ses… (more)

▼

Le complexe bc₁ de la chaîne respiratoire mitochondriale est une bonne cible thérapeutique pour traiter le paludisme car cette enzyme est essentielle au parasite. Ses deux sites actifs, Qo et Qi, formés par le cytochrome b, ne sont pas totalement conservés entre les espèces, facilitant la découverte d’inhibiteurs à affinité différentielle, ce qui est important dans le développement de médicaments. L’atovaquone est le seul antipaludique ciblant le complexe bc₁ utilisé en médecine. L’émergence de résistance rend urgente l’étude de nouveaux inhibiteurs. Les ELQs (Endochin-like Quinolones) sont une classe d’antipaludiques particulièrement prometteuse.Pour étudier la liaison des inhibiteurs dans les sites actifs et l’effet de mutations de résistance, nous utilisons la levure et des méthodes biochimiques et bio-informatiques. Dans ce travail, nous avons étudié la relation entre mutations de résistance à l’atovaquone dans le site Qo et perte de fonction. Nous avons aussi modifié le site Qo de la levure pour qu’il mime mieux le site de l’enzyme du parasite. Les résidus «Plasmodium» altèrent le fonctionnement du site, résultant en une surproduction d’ions superoxides et une perte de croissance respiratoire, qui est restaurée par la modification d’une autre sous-unité du complexe, ISP, partenaire du site Qo, suggérant que les deux sous-unités doivent s’ajuster pour un fonctionnement correct. Nous avons analysé des polymorphismes de la région Qo observés chez l’Homme et trouvé qu’ils peuvent modifier la sensibilité du complexe à l’atovaquone, ce qui pourrait avoir un impact sur les effets secondaires du traitement. Nous avons ensuite étudié le mode d’action d’ELQ-400 et montré que ce nouvel antipaludique cible les deux sites Qo et Qi, ce qui rend l’apparition de résistance peu probable. Enfin, nous avons commencé la reconstruction du site Qi de la levure pour mimer le site du parasite.Les mutants de levure avec un complexe bc₁ «Plasmodium» semblent être de bons outils pour l’étude des inhibiteurs. Leur étude a aussi permis de comprendre mieux la structure et le fonctionnement du complexe bc₁.

The bc₁ complex of the mitochondrial respiratory chain is a good therapeutic target for the treatment of malaria as the enzyme is essential for pathogen proliferation. The two catalytic sites, Qo and Qi, formed by cytochrome b, are not fully conserved between species, facilitating the development of inhibitors with differential saffinity, which is important for the development of new drugs. At present, Atovaquone is the only antimalarial drug targeting the bc₁ complex used in medicine. The emergence of resistance makes it important to find new inhibitors, and the ELQs (Endochin-like Quinolones) are promising antimalarial candidates.In order to study the inhibitor binding to the active sites and the effect of resistance mutations, we have used yeast and a combination of biochemical and bioinformatic methods. We have studied the relationship between atovaquone resistance mutations in the Qo site and loss of function. We have also modified…

Advisors/Committee Members: Meunier, Brigitte (thesis director).

Subjects/Keywords: Mitochondrie; Complexe III respiratoire; Mutation de résistance; Modèle levure; Drogues antipaludique; Polymorphisme humain; Mitochondrion; Respiratory complex III; Resistance mutation; Yeast model; Antimalarial drugs; Human polymorphism

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Song, Z. (2016). Agents antimicrobiens ciblant le complexe III de la chaine respiratoire mitochondriale : Etudes des déterminants structuraux de la sensibilité différentielle et du développement de la résistance, en utilisant la levure comme organisme modèle : Anti-microbial agents targeting complex III of the mitochondrial respiratory chain : Studying the structural determinants of differential sensitivity and the development of resistance, using yeast as a model organism. (Doctoral Dissertation). Université Paris-Saclay (ComUE). Retrieved from http://www.theses.fr/2016SACLS281

Chicago Manual of Style (16^th Edition):

Song, Zehua. “Agents antimicrobiens ciblant le complexe III de la chaine respiratoire mitochondriale : Etudes des déterminants structuraux de la sensibilité différentielle et du développement de la résistance, en utilisant la levure comme organisme modèle : Anti-microbial agents targeting complex III of the mitochondrial respiratory chain : Studying the structural determinants of differential sensitivity and the development of resistance, using yeast as a model organism.” 2016. Doctoral Dissertation, Université Paris-Saclay (ComUE). Accessed January 24, 2021. http://www.theses.fr/2016SACLS281.

MLA Handbook (7^th Edition):

Song, Zehua. “Agents antimicrobiens ciblant le complexe III de la chaine respiratoire mitochondriale : Etudes des déterminants structuraux de la sensibilité différentielle et du développement de la résistance, en utilisant la levure comme organisme modèle : Anti-microbial agents targeting complex III of the mitochondrial respiratory chain : Studying the structural determinants of differential sensitivity and the development of resistance, using yeast as a model organism.” 2016. Web. 24 Jan 2021.

Vancouver:

Song Z. Agents antimicrobiens ciblant le complexe III de la chaine respiratoire mitochondriale : Etudes des déterminants structuraux de la sensibilité différentielle et du développement de la résistance, en utilisant la levure comme organisme modèle : Anti-microbial agents targeting complex III of the mitochondrial respiratory chain : Studying the structural determinants of differential sensitivity and the development of resistance, using yeast as a model organism. [Internet] [Doctoral dissertation]. Université Paris-Saclay (ComUE); 2016. [cited 2021 Jan 24]. Available from: http://www.theses.fr/2016SACLS281.

Council of Science Editors:

Song Z. Agents antimicrobiens ciblant le complexe III de la chaine respiratoire mitochondriale : Etudes des déterminants structuraux de la sensibilité différentielle et du développement de la résistance, en utilisant la levure comme organisme modèle : Anti-microbial agents targeting complex III of the mitochondrial respiratory chain : Studying the structural determinants of differential sensitivity and the development of resistance, using yeast as a model organism. [Doctoral Dissertation]. Université Paris-Saclay (ComUE); 2016. Available from: http://www.theses.fr/2016SACLS281

University of Western Ontario

22. Lin, Lilian T. Hsp90 and its Co-chaperones Modify TDP-43 Localization, Aggregation, and Toxicity.

Degree: 2017, University of Western Ontario

URL: https://ir.lib.uwo.ca/etd/4434

► Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease associated with protein misfolding and protein aggregation. In particular, the TAR DNA-binding protein (TDP-43) is often found… (more)

Subjects/Keywords: Neurodegenerative diseases; amyotrophic lateral sclerosis; ALS; TDP-43; protein quality control; molecular chaperones; Hsp90; Sti1 Cdc37; Aha1; protein misfolding; protein aggregation; yeast model; Molecular Genetics; Nervous System Diseases

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lin, L. T. (2017). Hsp90 and its Co-chaperones Modify TDP-43 Localization, Aggregation, and Toxicity. (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/4434

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lin, Lilian T. “Hsp90 and its Co-chaperones Modify TDP-43 Localization, Aggregation, and Toxicity.” 2017. Thesis, University of Western Ontario. Accessed January 24, 2021. https://ir.lib.uwo.ca/etd/4434.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lin, Lilian T. “Hsp90 and its Co-chaperones Modify TDP-43 Localization, Aggregation, and Toxicity.” 2017. Web. 24 Jan 2021.

Vancouver:

Lin LT. Hsp90 and its Co-chaperones Modify TDP-43 Localization, Aggregation, and Toxicity. [Internet] [Thesis]. University of Western Ontario; 2017. [cited 2021 Jan 24]. Available from: https://ir.lib.uwo.ca/etd/4434.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lin LT. Hsp90 and its Co-chaperones Modify TDP-43 Localization, Aggregation, and Toxicity. [Thesis]. University of Western Ontario; 2017. Available from: https://ir.lib.uwo.ca/etd/4434

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

23. XIAO SHENG. FLEXIBLE QUANTITATIVE SIMULATION IN CELL CYCLE CONTROL, ALGORITHMS AND IMPLEMENTATION.

Degree: 2003, National University of Singapore

URL: https://scholarbank.nus.edu.sg/handle/10635/153890

Subjects/Keywords: Cell Cycle; In-silico experiment; Algorithm; Budding yeast; Deterministic model; Stochastic simulation; C++

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

SHENG, X. (2003). FLEXIBLE QUANTITATIVE SIMULATION IN CELL CYCLE CONTROL, ALGORITHMS AND IMPLEMENTATION. (Thesis). National University of Singapore. Retrieved from https://scholarbank.nus.edu.sg/handle/10635/153890

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

SHENG, XIAO. “FLEXIBLE QUANTITATIVE SIMULATION IN CELL CYCLE CONTROL, ALGORITHMS AND IMPLEMENTATION.” 2003. Thesis, National University of Singapore. Accessed January 24, 2021. https://scholarbank.nus.edu.sg/handle/10635/153890.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

SHENG, XIAO. “FLEXIBLE QUANTITATIVE SIMULATION IN CELL CYCLE CONTROL, ALGORITHMS AND IMPLEMENTATION.” 2003. Web. 24 Jan 2021.

Vancouver:

SHENG X. FLEXIBLE QUANTITATIVE SIMULATION IN CELL CYCLE CONTROL, ALGORITHMS AND IMPLEMENTATION. [Internet] [Thesis]. National University of Singapore; 2003. [cited 2021 Jan 24]. Available from: https://scholarbank.nus.edu.sg/handle/10635/153890.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

SHENG X. FLEXIBLE QUANTITATIVE SIMULATION IN CELL CYCLE CONTROL, ALGORITHMS AND IMPLEMENTATION. [Thesis]. National University of Singapore; 2003. Available from: https://scholarbank.nus.edu.sg/handle/10635/153890

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Brandeis University

24. Sankaran, Saumya M. A functional analysis of the mammalian E3 ubiquitin ligase WWP1 in a yeast model.

Degree: 2009, Brandeis University

URL: http://hdl.handle.net/10192/23252

► E3 ubiquitin ligases function in the ubiquitin proteasome pathway as a key component in the regulation of protein degradation. With their implications in a range… (more)

Subjects/Keywords: WWP1; WW domain; drug screen assay; HECT domain; E3 ubiquitin ligase; yeast model

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APA (6^th Edition):

Sankaran, S. M. (2009). A functional analysis of the mammalian E3 ubiquitin ligase WWP1 in a yeast model. (Thesis). Brandeis University. Retrieved from http://hdl.handle.net/10192/23252

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sankaran, Saumya M. “A functional analysis of the mammalian E3 ubiquitin ligase WWP1 in a yeast model.” 2009. Thesis, Brandeis University. Accessed January 24, 2021. http://hdl.handle.net/10192/23252.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sankaran, Saumya M. “A functional analysis of the mammalian E3 ubiquitin ligase WWP1 in a yeast model.” 2009. Web. 24 Jan 2021.

Vancouver:

Sankaran SM. A functional analysis of the mammalian E3 ubiquitin ligase WWP1 in a yeast model. [Internet] [Thesis]. Brandeis University; 2009. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/10192/23252.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sankaran SM. A functional analysis of the mammalian E3 ubiquitin ligase WWP1 in a yeast model. [Thesis]. Brandeis University; 2009. Available from: http://hdl.handle.net/10192/23252

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Virginia Tech

25. Lee, Andrew H. Impact of cocoa (Theobroma cacao L.) fermentation on composition and concentration of polyphenols: Development of fermentation model system and utilization of yeast starter cultures.

Degree: PhD, Food Science and Technology, 2017, Virginia Tech

URL: http://hdl.handle.net/10919/88515

► Consumption of cocoa and dark chocolate products has been associated with positive health outcomes including reduced onset of cardiovascular disease, inflammation, diabetes, obesity, and platelet… (more)

▼ Consumption of cocoa and dark chocolate products has been associated with positive health outcomes including reduced onset of cardiovascular disease, inflammation, diabetes, obesity, and platelet disorders. Cocoa polyphenols, putatively responsible for these beneficial activities, are highly impacted by cocoa variety, agronomic effects and processing history. However, the difference in polyphenol concentration and composition between cocoa products originating from different hybrid clones (selected for high yield) or from different fermentation conditions is not fully understood. Detailed polyphenol characterization including determination of total polyphenol and total procyanidin concentrations, and qualitative and quantitative analysis of (mean) degree of polymerization was conducted. Significant differences in total polyphenol and procyanidin concentrations were observed between five genetic clones grown by the USDA-ARS Cocoa Germplasm Repository located in Mayagüez, Puerto Rico. To facilitate cocoa fermentation research in laboratories distant from cocoa harvesting sites, a laboratory-scale cocoa fermentation model system was developed in this study. This model system used dried, unfermented, cocoa beans and simulated pulp medium as the starting material. The model system supported growth of the essential succession of cocoa fermenting microorganisms and generated similar chemical changes to those observed in on-farm cocoa fermentation. Using this model system, the impact of inoculation with proprietary yeast strains Saccharomyces cerevisiae Lev F and Saccharomyces cerevisiae Lev B on cocoa polyphenol concentration and composition was evaluated. Inoculation with both yeast strains resulted in increased fermentation rate and Lev B inoculation resulted in higher total polyphenol and procyandin contents at the end of fermentation. Overall, the present work addressed the influence of cocoa variety selection and fermentation process conditions on the composition and concentration of polyphenols. These findings will contribute to continued efforts to develop cocoa products with optimized bioactivity and maximum disease preventative effects. Advisors/Committee Members: Stewart, Amanda C. (committeechair), Ogejo, Jactone Arogo (committee member), Neilson, Andrew P. (committee member), O'Keefe, Sean F. (committee member).

Subjects/Keywords: Cocoa fermentation; laboratory model system; yeast starter inoculation; microbial identification; metabolite analysis (HPLC); volatile compound analysis (GC-MS); total polyphenol; total procyanidin; degree of polymerization

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lee, A. H. (2017). Impact of cocoa (Theobroma cacao L.) fermentation on composition and concentration of polyphenols: Development of fermentation model system and utilization of yeast starter cultures. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/88515

Chicago Manual of Style (16^th Edition):

Lee, Andrew H. “Impact of cocoa (Theobroma cacao L.) fermentation on composition and concentration of polyphenols: Development of fermentation model system and utilization of yeast starter cultures.” 2017. Doctoral Dissertation, Virginia Tech. Accessed January 24, 2021. http://hdl.handle.net/10919/88515.

MLA Handbook (7^th Edition):

Lee, Andrew H. “Impact of cocoa (Theobroma cacao L.) fermentation on composition and concentration of polyphenols: Development of fermentation model system and utilization of yeast starter cultures.” 2017. Web. 24 Jan 2021.

Vancouver:

Lee AH. Impact of cocoa (Theobroma cacao L.) fermentation on composition and concentration of polyphenols: Development of fermentation model system and utilization of yeast starter cultures. [Internet] [Doctoral dissertation]. Virginia Tech; 2017. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/10919/88515.

Council of Science Editors:

Lee AH. Impact of cocoa (Theobroma cacao L.) fermentation on composition and concentration of polyphenols: Development of fermentation model system and utilization of yeast starter cultures. [Doctoral Dissertation]. Virginia Tech; 2017. Available from: http://hdl.handle.net/10919/88515

Wright State University

26. Islam, Md Moydul. Characterization of the Effect of Optineurin on Alpha-synuclein Aggregation andToxicity in Yeast.

Degree: MS, Biological Sciences, 2018, Wright State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=wright1535409230684852

► Optineurin, an autophagy adaptor protein genetically linked to Normal Tension Glaucoma and Amyotrophic Lateral Sclerosis, has been found in the pathological inclusions of various other… (more)

Subjects/Keywords: Neurosciences; Genetics; Cellular Biology; Neurodegeneration; Optineurin; Alpha-synuclein; Amyotrophic Lateral Sclerosis; Normal Tension Glaucoma; Autophagy; Yeast model; Physical interaction mapping; Genetic interaction mapping

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Islam, M. M. (2018). Characterization of the Effect of Optineurin on Alpha-synuclein Aggregation andToxicity in Yeast. (Masters Thesis). Wright State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=wright1535409230684852

Chicago Manual of Style (16^th Edition):

Islam, Md Moydul. “Characterization of the Effect of Optineurin on Alpha-synuclein Aggregation andToxicity in Yeast.” 2018. Masters Thesis, Wright State University. Accessed January 24, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=wright1535409230684852.

MLA Handbook (7^th Edition):

Islam, Md Moydul. “Characterization of the Effect of Optineurin on Alpha-synuclein Aggregation andToxicity in Yeast.” 2018. Web. 24 Jan 2021.

Vancouver:

Islam MM. Characterization of the Effect of Optineurin on Alpha-synuclein Aggregation andToxicity in Yeast. [Internet] [Masters thesis]. Wright State University; 2018. [cited 2021 Jan 24]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=wright1535409230684852.

Council of Science Editors:

Islam MM. Characterization of the Effect of Optineurin on Alpha-synuclein Aggregation andToxicity in Yeast. [Masters Thesis]. Wright State University; 2018. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=wright1535409230684852

University of Rochester

27. Tyagi, Rahul. Predicting RNA Structure and Discovering Functional RNA Sequences in Genomes Using Folding Thermodynamics.

Degree: PhD, 2009, University of Rochester

URL: http://hdl.handle.net/1802/8162

► RNA is more than just an information carrier that constitutes the intermediate stage between DNA and protein as suggested in the original Central Dogma of… (more)

Subjects/Keywords: Coaxial Stacking; RNA Structure; ncRNA; Non-coding RNA; Nearest-Neighbor Model; Dymalign; Yeast Genome; Multibranch Loop

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APA (6^th Edition):

Tyagi, R. (2009). Predicting RNA Structure and Discovering Functional RNA Sequences in Genomes Using Folding Thermodynamics. (Doctoral Dissertation). University of Rochester. Retrieved from http://hdl.handle.net/1802/8162

Chicago Manual of Style (16^th Edition):

Tyagi, Rahul. “Predicting RNA Structure and Discovering Functional RNA Sequences in Genomes Using Folding Thermodynamics.” 2009. Doctoral Dissertation, University of Rochester. Accessed January 24, 2021. http://hdl.handle.net/1802/8162.

MLA Handbook (7^th Edition):

Tyagi, Rahul. “Predicting RNA Structure and Discovering Functional RNA Sequences in Genomes Using Folding Thermodynamics.” 2009. Web. 24 Jan 2021.

Vancouver:

Tyagi R. Predicting RNA Structure and Discovering Functional RNA Sequences in Genomes Using Folding Thermodynamics. [Internet] [Doctoral dissertation]. University of Rochester; 2009. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/1802/8162.

Council of Science Editors:

Tyagi R. Predicting RNA Structure and Discovering Functional RNA Sequences in Genomes Using Folding Thermodynamics. [Doctoral Dissertation]. University of Rochester; 2009. Available from: http://hdl.handle.net/1802/8162

Linköping University

28. Fransson, Martin. Identification of a Genetic Network in the Budding Yeast Cell Cycle.

Degree: Electrical Engineering, 2004, Linköping University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-2389

► By using AR/ARX-models on data generated by a nonlinear differential equation system representing a model for the cell-cycle control system in budding yeast, the… (more)

Subjects/Keywords: Reglerteknik; Genetic network; Budding yeast cell; Auto regression; State-space model; Reglerteknik; Automatic control; Reglerteknik

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APA (6^th Edition):

Fransson, M. (2004). Identification of a Genetic Network in the Budding Yeast Cell Cycle. (Thesis). Linköping University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-2389

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Fransson, Martin. “Identification of a Genetic Network in the Budding Yeast Cell Cycle.” 2004. Thesis, Linköping University. Accessed January 24, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-2389.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Fransson, Martin. “Identification of a Genetic Network in the Budding Yeast Cell Cycle.” 2004. Web. 24 Jan 2021.

Vancouver:

Fransson M. Identification of a Genetic Network in the Budding Yeast Cell Cycle. [Internet] [Thesis]. Linköping University; 2004. [cited 2021 Jan 24]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-2389.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Fransson M. Identification of a Genetic Network in the Budding Yeast Cell Cycle. [Thesis]. Linköping University; 2004. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-2389

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

29. Portell Canal, Xavier. Individual-based observations and individual-based simulations to study Saccharomyces cerevisiae cultures.

Degree: Departament d'Enginyeria Agroalimentària i Biotecnologia, 2014, Universitat Politècnica de Catalunya

URL: http://hdl.handle.net/10803/284741

► El Saccharomyces cerevisiae és un dels llevats que gaudeix de més significació econòmica, social i per a la salut humana. Depenent de les condicions experimentades,… (more)

▼ El Saccharomyces cerevisiae és un dels llevats que gaudeix de més significació econòmica, social i per a la salut humana. Depenent de les condicions experimentades, el llevat S. cerevisiae pot créixer mitjançant un metabolisme fermentatiu, respiratori o respirofermentatiu. La formació de cicatrius, una divisió desigual, una vida replicativa limitada i un increment de la mida de la cèl.lula amb l’edat replicativa són característiques individuals d’aquest llevat que afecten el comportament dels bioprocessos. Aquestes característiques incrementen la complexitat dels models predictius i dificulten, per tant, la seva inclusió en un model continu de manera realista. No obstant això, un model basat en l’individu sí que és capaç d’acomodar tota aquesta complexitat en un únic model computacional. Una vegada implementat, un model basat en l’individu ha de ser parametritzat, calibrat i la seva adequació ha de ser avaluada. Tots aquests processos requereixen idealment un gran nombre d’observacions experimentals, tant individuals com a nivell del sistema estudiat. L’objectiu general de la tesi present és avançar en el desenvolupament d’una metodologia basada en l’individu per estudiar sistemes microbians conduïts pel llevat S. cerevisiae. Primerament s’avalua l’adequació de INDISIM-YEAST, un model basat en l’individu, ja existent, focalitzat en un llevat genèric. Es verifica i s’avalua la diversitat del S. cerevisiae en observacions experimentals orientades a l’individu en diferents condicions de creixement i en diversos estadis de la corba de creixement de la població. Això permet obtenir observacions basades en l’individu molt valuoses a l’hora de donar suport a la metodologia desitjada. Es desenvolupa i s’implementa en Fortran 90 INDISIM-Saccha, un model quantitatiu basat en l’individu i focalitzat en el creixement fermentatiu (anaerobi) del S. cerevisiae. El model desenvolupat és parametritzat, calibrat, la seva adequació és avaluada i és utilitzat per estudiar in silico la producció d’etanol mitjançant experiments virtuals. El procés de calibratge, l’obtenció i l’anàlisi de les dades dels experiments virtuals s’han realitzat utilitzant el programari estadístic R. L’adequació del model s’avalua testejant diferents prediccions del model a nivell de sistema (corbes de disminució de la glucosa i de creixement de la població) i a nivell de la cèllula individual (evolucions temporals de la fracció de cèl.lules gemades, de la distribució d’edats genealògiques i de la distribució dels diàmetres cel.lulars). Les observacions del diàmetre de les cèl.lules individuals obtingudes a la tesi present juguen un paper significatiu en aquesta avaluació. Els resultats dels experiments virtuals suggereixen que les diferències en la distribució de mides cel.lulars poden afectar dràsticament l’evolució i la productivitat de les fermentacions i suggereixen una caracterització rutinària de l’inòcul a la indústria biotecnològica. L’INDISIM-Saccha també és adaptat per tenir en compte el creixement aeròbic del S. cerevisiae i és contrastat… Advisors/Committee Members: [email protected] (authoremail), false (authoremailshow), Gras, Anna (director), Ginovart, Marta (codirector), true (authorsendemail).

Subjects/Keywords: Llevat; Model basat en l’individu; NetLogo; Experiment virtual; Yeast; Virtual experiment; Flow cytometry; Electrical particle analysis; Light diffraction; 51; 579; 663/664

…llevat S. cerevisiae. Primerament s’avalua l’adequació de INDISIM-YEAST, un model basat en… …based model of a generic budding yeast, is first assessed. In order to obtain valuable… …individual-based model focusing on the fermentative (anaerobic) growth of the yeast S… …Saccha. Keywords: yeast,individual-based model, parameterization, calibration, model adequacy… …Assessment of the INDISIM-YEAST adequacy as a core model 3.1 Introduction…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Portell Canal, X. (2014). Individual-based observations and individual-based simulations to study Saccharomyces cerevisiae cultures. (Thesis). Universitat Politècnica de Catalunya. Retrieved from http://hdl.handle.net/10803/284741

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Portell Canal, Xavier. “Individual-based observations and individual-based simulations to study Saccharomyces cerevisiae cultures.” 2014. Thesis, Universitat Politècnica de Catalunya. Accessed January 24, 2021. http://hdl.handle.net/10803/284741.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Portell Canal, Xavier. “Individual-based observations and individual-based simulations to study Saccharomyces cerevisiae cultures.” 2014. Web. 24 Jan 2021.

Vancouver:

Portell Canal X. Individual-based observations and individual-based simulations to study Saccharomyces cerevisiae cultures. [Internet] [Thesis]. Universitat Politècnica de Catalunya; 2014. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/10803/284741.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Portell Canal X. Individual-based observations and individual-based simulations to study Saccharomyces cerevisiae cultures. [Thesis]. Universitat Politècnica de Catalunya; 2014. Available from: http://hdl.handle.net/10803/284741

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of New South Wales

30. Negaresh, Ebrahim. Particle and macromolecular fouling in submerged membrane.

Degree: Chemical Sciences & Engineering, 2007, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/40743 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:1341/SOURCE02?view=true

► Particles and macromolecular components, including biopolymers (protein and carbohydrate), are viewed as the main foulants in the complex feed submerged membrane filtration systems such as… (more)

▼ Particles and macromolecular components, including biopolymers (protein and carbohydrate), are viewed as the main foulants in the complex feed submerged membrane filtration systems such as membrane bioreactor (MBR). This work focused on two aspects of fouling in complex fluids: 1- Assessing fouling propensity and mechanisms for various model solutions. 2- Using of two specific solutions modelling biomass found in MBR for a better understanding of the fouling mechanisms in submerged MBR processes. Filtrations were carried out with 0.22 µm PVDF hollow fibre membrane.Alginate was used as a model for polysaccharide, bovine serum albumin (BSA) as a model for protein, (un)washed yeast and bentonite were representing suspended solid contents. According to the data obtained during this study the fouling propensity of each model solution was classified as follow in a decreasing order: Alginate > unwashed yeast > washed yeast > BSA > bentonite for one-component solutions; and Alginate-washed yeast > Alginate-BSA > Alginate-bentonite > Alginate-unwashed yeast for two-component solutions. Introducing the alginate increased the reversible fouling (except BSA). Passive adsorption had a significant effect on fouling of alginate even before the beginning of the filtration. Washed yeast and a mixture of washed yeast + BSA were then used as model solutions to simulate the activated sludge found in MBR. The concentration of washed yeast and BSA used in this study were calculated in order for the characterisations of the two model solution to match (in terms of biopolymer contents) those of MBR biomasses reported in the literature. By rinsing, backwashing and chemical cleaning of the membrane, three fouling layers of upper, intermediate and lower were defined respectively. Results obtained from the analysis of the biopolymers found in the cleaning solutions allow a better understanding of the fouling mechanisms occurring for the two model solutions used in this study: for washed yeast, the lower layer and for washed yeast + BSA , the upper and intermediate layers were found to have relatively high biopolymeric composition. This was explained by higher concentration of solids on the membrane surface and by higher biopolymer interactions when washed yeast was mixed with BSA.

Subjects/Keywords: Membrane bioreactor; Fouling; Membrane filters; Particles; Carbohydrate; Model solutions; Extracellular polymeric.substances; Alginate; Yeast; Bovine serum albumin; Polysaccharide; Bentonite; Biopolymer; Hollow fibre; Characterisation; Soluble microbial products; Macromolecular; Fouling organisms

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Negaresh, E. (2007). Particle and macromolecular fouling in submerged membrane. (Masters Thesis). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/40743 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:1341/SOURCE02?view=true

Chicago Manual of Style (16^th Edition):

Negaresh, Ebrahim. “Particle and macromolecular fouling in submerged membrane.” 2007. Masters Thesis, University of New South Wales. Accessed January 24, 2021. http://handle.unsw.edu.au/1959.4/40743 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:1341/SOURCE02?view=true.

MLA Handbook (7^th Edition):

Negaresh, Ebrahim. “Particle and macromolecular fouling in submerged membrane.” 2007. Web. 24 Jan 2021.

Vancouver:

Negaresh E. Particle and macromolecular fouling in submerged membrane. [Internet] [Masters thesis]. University of New South Wales; 2007. [cited 2021 Jan 24]. Available from: http://handle.unsw.edu.au/1959.4/40743 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:1341/SOURCE02?view=true.

Council of Science Editors:

Negaresh E. Particle and macromolecular fouling in submerged membrane. [Masters Thesis]. University of New South Wales; 2007. Available from: http://handle.unsw.edu.au/1959.4/40743 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:1341/SOURCE02?view=true

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