You searched for subject:(West Nile Virus).
Showing records 1 – 30 of
231 total matches.
◁ [1] [2] [3] [4] [5] [6] [7] [8] ▶
University of Hawaii – Manoa
1.
Roe, Kelsey Olds.
Characterization of the markers of blood-brain barrier disruption in West Nile virus infected mice.
Degree: 2016, University of Hawaii – Manoa
URL: http://hdl.handle.net/10125/101576 
► M.S. University of Hawaii at Manoa 2011.
Purpose: West Nile virus (WNV) disease is characterized by neuronal loss, neuroinflammation and increased permeability of the blood-brain…
(more)
▼ M.S. University of Hawaii at Manoa 2011.
Purpose: West Nile virus (WNV) disease is characterized by neuronal loss, neuroinflammation and increased permeability of the blood-brain barrier (BBB). Several in vivo studies demonstrate that BBB disruption and virus replication in the brain correlates with mortality associated with WNV-encephalitis. BBB integrity is maintained through complex interactions between the tight junction proteins (TJP), adherens junction proteins (AJP) of the microvascular endothelial cells (EC). Matrix metalloproteinases (MMPs) are endopeptidases that are known to degrade components of the basal lamina of the BBB as well as multiple TJP, contributing to BBB disruption in several neuroinflammatory diseases. Our previous in vitro studies demonstrated that multiple MMPs secreted by WNV-infected astrocytes degrade TJP of the EC and compromise the integrity of the in vitro BBB model. However, the precise mechanisms underlying BBB disruption in vivo, specifically the kinetics of the morphological changes in tight junctions of the BBB and the relationship of BBB breakdown with virus replication in the brain are unclear. Therefore, the objective of this study was to determine the in vivo effect of WNV infection on the BBB integrity markers in the mouse brain.
Methods: Ten-week old C57BL/6 mice were inoculated via footpad with 100 PFU of WNV and serum, spleen, kidney, and brain tissues were collected at days 2, 4, 6 and 8 after infection. In addition, BBB permeability was assessed using Evan's blue dye at days 6 and 8 after infection. Expression of TJP, AJP and MMP was analyzed using quantitative reverse transcriptase-PCR, ELISA, Western blotting or immunohistochemical staining. A separate group of mice were inoculated via the intracranial route with 100 PFU of WNV, and brains were harvested at day 6 for analysis of TJP, AJP, and MMPs.
Results: Peak peripheral viremia was observed at day 3 after infection and the virus was mostly cleared by day 6. In the brain, WNV was not detected at day 3 after infection, however robust virus replication was observed at day 6 and 8 after infection. Leakage of Evans blue dye into the brain was minimal at day 6 after infection, and became intense at day 8 after infection, suggesting disruption of the BBB. The mRNA levels of TJP (claudin-1, occludin, zonula occludin-1 (ZO-1), and junctioanl adhesion molecule-A (JAM-A)) and AJP (VE-cadherin and β-catenin) in the brain did not alter at any time point after infection. Although there was no significant change in the protein level of TJP or AJP at day 4 after infection, these proteins decreased slightly in the WNV-infected brain at day 6 after infection, which became more pronounced and significant at day 8 after infection. These results were validated using immunostaining of brain sections at day 8 after infection. Similarly, at day 8 after infection, the mRNA and protein expressions of MMP-1,-3, and-9 in WNV-infected brain increased significantly and correlated with high WNV titers in the brain. Assay of MMP-9 in the…
Subjects/Keywords: West Nile virus
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Roe, K. O. (2016). Characterization of the markers of blood-brain barrier disruption in West Nile virus infected mice. (Thesis). University of Hawaii – Manoa. Retrieved from http://hdl.handle.net/10125/101576
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Roe, Kelsey Olds. “Characterization of the markers of blood-brain barrier disruption in West Nile virus infected mice.” 2016. Thesis, University of Hawaii – Manoa. Accessed January 17, 2021.
http://hdl.handle.net/10125/101576.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Roe, Kelsey Olds. “Characterization of the markers of blood-brain barrier disruption in West Nile virus infected mice.” 2016. Web. 17 Jan 2021.
Vancouver:
Roe KO. Characterization of the markers of blood-brain barrier disruption in West Nile virus infected mice. [Internet] [Thesis]. University of Hawaii – Manoa; 2016. [cited 2021 Jan 17].
Available from: http://hdl.handle.net/10125/101576.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Roe KO. Characterization of the markers of blood-brain barrier disruption in West Nile virus infected mice. [Thesis]. University of Hawaii – Manoa; 2016. Available from: http://hdl.handle.net/10125/101576
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Hawaii – Manoa
2.
Kumar, Mukesh.
Diabetes as a risk factor for West Nile virus-associated encephalitis.
Degree: 2016, University of Hawaii – Manoa
URL: http://hdl.handle.net/10125/101980
► Ph.D. University of Hawaii at Manoa 2013.
Background: Diabetes mellitus is a significant risk factor for West Nile virus (WNV) encephalitis (WNVE), the leading cause…
(more)
▼ Ph.D. University of Hawaii at Manoa 2013.
Background: Diabetes mellitus is a significant risk factor for West Nile virus (WNV) encephalitis (WNVE), the leading cause of arboviral encephalitis in the U.S. However, no experimental studies have elucidated the role of diabetes in WNV neuropathogenesis. Therefore, the objective of this study was to employ a diabetic mouse model, db/db, and evaluate the progression of WNV disease as well as the resultant host antiviral immune response to better understand WNV immunopathogenesis in diabetics.
Methods: db/db mice and wild-type (WT) mice were inoculated with 10 PFU of WNV and clinical symptoms and mortality were observed for 21 days. Virus burden in the serum, peripheral organs and brain was analyzed by plaque assay. Host immune responses such as interferon, antibodies production, leukocyte infiltration, expression of cell adhesion molecules (CAM) and levels of cytokines and chemokines in the serum and brain were determined by qRT-PCR, WB, ELISA, Luminex assay, PCR arrays and flow cytometry. Further, activation of astrocytes and neuronal death were evaluated by immunohistochemistry and TUNEL assay.
Results: Our results demonstrate that db/db mice were highly susceptible to WNV disease, exhibited increased tissue tropism and mortality than the WT mice, and were unable to clear the infection. Increased and sustained WNV replication was observed in the serum, peripheral tissues and brain of db/db mice. Antiviral immune response was impaired in db/db mice as characterized by delayed induction of IFN-α, significantly reduced levels of WNV-specific antibodies and reduced infiltration of immune cells in the brain. db/db mice exhibited attenuated expression of CAM such as Eselectin, and ICAM-1, which correlated with reduced immune cells recruitment in the brain. WNV infection in db/db mice was also associated with enhanced inflammatory response in the serum and brain. Elevated levels of cytokines correlated with increase in astrocytes activation and neuronal damage in the brain of db/db mice.
Conclusion: These data suggest that compromised immune response coupled with failure to clear virus leads to increased mortality in db/db mice. Our findings provide direct experimental evidence of diabetes as a risk factor for WNVE and provide unique mechanistic insight into the immunopathogenesis of WNVE in diabetics.
Subjects/Keywords: West Nile virus
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Kumar, M. (2016). Diabetes as a risk factor for West Nile virus-associated encephalitis. (Thesis). University of Hawaii – Manoa. Retrieved from http://hdl.handle.net/10125/101980
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Kumar, Mukesh. “Diabetes as a risk factor for West Nile virus-associated encephalitis.” 2016. Thesis, University of Hawaii – Manoa. Accessed January 17, 2021.
http://hdl.handle.net/10125/101980.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Kumar, Mukesh. “Diabetes as a risk factor for West Nile virus-associated encephalitis.” 2016. Web. 17 Jan 2021.
Vancouver:
Kumar M. Diabetes as a risk factor for West Nile virus-associated encephalitis. [Internet] [Thesis]. University of Hawaii – Manoa; 2016. [cited 2021 Jan 17].
Available from: http://hdl.handle.net/10125/101980.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Kumar M. Diabetes as a risk factor for West Nile virus-associated encephalitis. [Thesis]. University of Hawaii – Manoa; 2016. Available from: http://hdl.handle.net/10125/101980
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Texas A&M University
3.
Laine, Christopher Glen.
Mathematical Modeling the Zoonotic and Vector Transmission Dynamics of West Nile virus as They Relate to Human Morbidity and Mortality.
Degree: Doctor of Public Health, Epidemiology and Environmental Health, 2014, Texas A&M University
URL: http://hdl.handle.net/1969.1/153915
► West Nile virus (WNV), an arthropod-borne flavivirus, naturally circulates between passeriform birds and mosquitoes. Other vertebrates, such as humans, may become infected during the bloodmeal…
(more)
▼ West Nile virus (WNV), an arthropod-borne flavivirus, naturally circulates between passeriform birds and mosquitoes. Other vertebrates, such as humans, may become infected during the bloodmeal of infectious mosquitoes. WNV initially invaded New York in 1999, rapidly swept
west across the North American continent, and is now endemic across the continental United States. The focus of this study was to use mathematical modeling, for improving current public health understanding on how infectious cycles of birds and mosquitoes, infection and cross-infection, and environmental dynamics of WNV, along with human pathology, influences human morbidity and mortality in the Dallas, Tarrant, and Denton counties of Texas.
During a comprehensive literature review of WNV, avian pathophysiology, public health entomology, human pathophysiology, and epidemiology, we proposed a novel mathematical model. Subsequently, we developed an epidemic model of the WNV dynamics, in the avian host (American crow), mosquito vector (Culex), and two age classifications of humans (≤39 & ≥40). The bifurcation of human age was conducted due to the risk of humans developing neuroinvasive disease increases 1.5X for every decade of life. We also divided human infected classes into asymptomatic,
West Nile Fever (WNF), and
West Nile neuroinvasive disease (WNND), as WNND is the only fatal form. The model was then calibrated to observed data, from the endemic years between 2003-1012. A sensitivity analysis of each individual variable and parameter was conducted to test influence on human morbidity and mortality. Focusing on the most sensitive variables, we conducted a multivariate analysis, in which we formulated situations such as drought, avian concentration and population fragmentation, insecticide usage, larvae side usage, and habitat modification through the reduction of standing water.
We were able to successfully simulate the endemic years, and outbreaks, between 2003 and 2012, but underestimated the outbreak year of 2012. This model illustrates the observed link between infected mosquito densities to human health outcomes. Climate changes that effect the mosquito population and their interaction with humans have been shown to be important factors influencing human morbidity and mortality. In the future this model may also be useful in predicting the effect of various disease control strategies.
Advisors/Committee Members: Lillibridge, Scott R (advisor), Bissett, Wesley (committee member), Cizmas, Leslie (committee member), Tekwe, Carmen (committee member).
Subjects/Keywords: West Nile virus; West Nile virus epidemiology; West Nile virus disease modeling; West Nile virus mathematical modeling; neuroinvasive West Nile virus
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Laine, C. G. (2014). Mathematical Modeling the Zoonotic and Vector Transmission Dynamics of West Nile virus as They Relate to Human Morbidity and Mortality. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/153915
Chicago Manual of Style (16th Edition):
Laine, Christopher Glen. “Mathematical Modeling the Zoonotic and Vector Transmission Dynamics of West Nile virus as They Relate to Human Morbidity and Mortality.” 2014. Doctoral Dissertation, Texas A&M University. Accessed January 17, 2021.
http://hdl.handle.net/1969.1/153915.
MLA Handbook (7th Edition):
Laine, Christopher Glen. “Mathematical Modeling the Zoonotic and Vector Transmission Dynamics of West Nile virus as They Relate to Human Morbidity and Mortality.” 2014. Web. 17 Jan 2021.
Vancouver:
Laine CG. Mathematical Modeling the Zoonotic and Vector Transmission Dynamics of West Nile virus as They Relate to Human Morbidity and Mortality. [Internet] [Doctoral dissertation]. Texas A&M University; 2014. [cited 2021 Jan 17].
Available from: http://hdl.handle.net/1969.1/153915.
Council of Science Editors:
Laine CG. Mathematical Modeling the Zoonotic and Vector Transmission Dynamics of West Nile virus as They Relate to Human Morbidity and Mortality. [Doctoral Dissertation]. Texas A&M University; 2014. Available from: http://hdl.handle.net/1969.1/153915
Universiteit Utrecht
4.
Nijdam, P.
Establishment of an immunohistochemical method to detect West Nile virus in formalin-fixed paraffin-embedded tissues.
Degree: 2013, Universiteit Utrecht
URL: http://dspace.library.uu.nl:8080/handle/1874/285248
► With the emergence of West Nile virus in Northern America and the re-emergence ofthe virus in Europe, the relevance of West Nile virus as a…
(more)
▼ With the emergence of
West Nile virus in Northern America and the re-emergence ofthe
virus in Europe, the relevance of
West Nile virus as a pathogen has beenunderlined. In particular the quick spread on the American continent and the increasein virulence, compared to previous appearances, have lead to healthcare concerns.Reliable and accurate laboratory methods to detect this
virus are thereforenecessary. One of them is immunohistochemistry, which is an important instrument inresearch and histological pathology. In order to retrieve reproducible and reliableresults from tests, it is of utmost importance to work in a fixed order, or protocol.Protocols are also important since no two laboratories are the same in theirpreferences and working habits. The aim of this study was to establish such aprotocol, in this case for the detection of
West Nile virus in tissues.For the establishment of this protocol, a series of experiments were performed, inwhich different variables were tested, eventually resulting in a protocol that producessatisfactory results and can easily be reproduced. After the establishment of the protocol, several avian, equine and wildlife cases of a possible
West Nile virus infection were tested. However, no positive cases were found.
Advisors/Committee Members: Gröne, A..
Subjects/Keywords: Diergeneeskunde; West Nile virus, immunohistochemistry
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Nijdam, P. (2013). Establishment of an immunohistochemical method to detect West Nile virus in formalin-fixed paraffin-embedded tissues. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/285248
Chicago Manual of Style (16th Edition):
Nijdam, P. “Establishment of an immunohistochemical method to detect West Nile virus in formalin-fixed paraffin-embedded tissues.” 2013. Masters Thesis, Universiteit Utrecht. Accessed January 17, 2021.
http://dspace.library.uu.nl:8080/handle/1874/285248.
MLA Handbook (7th Edition):
Nijdam, P. “Establishment of an immunohistochemical method to detect West Nile virus in formalin-fixed paraffin-embedded tissues.” 2013. Web. 17 Jan 2021.
Vancouver:
Nijdam P. Establishment of an immunohistochemical method to detect West Nile virus in formalin-fixed paraffin-embedded tissues. [Internet] [Masters thesis]. Universiteit Utrecht; 2013. [cited 2021 Jan 17].
Available from: http://dspace.library.uu.nl:8080/handle/1874/285248.
Council of Science Editors:
Nijdam P. Establishment of an immunohistochemical method to detect West Nile virus in formalin-fixed paraffin-embedded tissues. [Masters Thesis]. Universiteit Utrecht; 2013. Available from: http://dspace.library.uu.nl:8080/handle/1874/285248
Rutgers University
5.
Shappell, Laura Jean, 1984-.
Urban wetland structure and its relationship to exotic plants, biodiversity, and West Nile virus risk.
Degree: PhD, Ecology and Evolution, 2015, Rutgers University
URL: https://rucore.libraries.rutgers.edu/rutgers-lib/48651/
► Wetlands provide crucial ecosystem functions that aid water security, stormwater management, and biodiversity conservation. However, the underlying mechanisms that influence headwater wetlands in urban landscapes…
(more)
▼ Wetlands provide crucial ecosystem functions that aid water security, stormwater management, and biodiversity conservation. However, the underlying mechanisms that influence headwater wetlands in urban landscapes are poorly understood. Further, biodiversity loss may reduce ecosystem function and increase the transmission risk for some enzootic diseases, such as West Nile virus (WNV). My research aimed to: 1) assess wetland vegetation structure and the importance of fragment size and landscape position on biodiversity; 2) test the importance of flooding conditions for mitigating invasive plant dominance in forested wetlands using Japanese stiltgrass (Microstegium vimineum) as my study system; and 3) identify relationships between vegetation structure, fragment size, and the relative abundance of competent avian WNV hosts and mosquito vectors. I used a combination of measurative and experimental research methods to address these objectives, the third of which was part of a collaborative interdisciplinary research grant. Vegetation structure was measured in 36 plots located in six forested wetlands and data loggers were used to monitor aboveground flooding. Avian and mosquito research teams coordinated iii with my sampling points. My results illustrate the capacity for urban headwater wetlands to support a diverse flora, as well as the complex interactions between human activities and wetland structure and function. Red maple, oak, sweetgum, and green ash were the dominant tree species. Half of the 287 plant species identified only occurred at 1-2 sample points. Groundcover composition reflected the confluence of hydrogeomorphology, and past and present human actions. Connectivity via nearby streams or ditches had a greater impact on exotic plant richness than did wetland patch size. Aboveground flooding prior to seedling emergence significantly reduced the distribution of Japanese stiltgrass. Avian species richness was positively correlated with plant richness. In contrast, mosquito richness was negatively correlated to plant richness. WNV hosts and vector abundance both increased with maple (Acer spp.) tree canopy dominance. Cumulative host abundance averaged 24% and was composed primarily of American Robin, which showed large interannual shifts in fragments <15 ha. The relative abundance of competent vectors ranged from 5 to 26% and their populations demonstrated less interannual variation than were observed in the host populations.
Advisors/Committee Members: Struwe, Lena (chair), Hartman, Jean Marie (internal member), Handel, Steven (internal member), Schneider, Laura (outside member).
Subjects/Keywords: West Nile virus; Wetlands; Biodiversity
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Shappell, Laura Jean, 1. (2015). Urban wetland structure and its relationship to exotic plants, biodiversity, and West Nile virus risk. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/48651/
Chicago Manual of Style (16th Edition):
Shappell, Laura Jean, 1984-. “Urban wetland structure and its relationship to exotic plants, biodiversity, and West Nile virus risk.” 2015. Doctoral Dissertation, Rutgers University. Accessed January 17, 2021.
https://rucore.libraries.rutgers.edu/rutgers-lib/48651/.
MLA Handbook (7th Edition):
Shappell, Laura Jean, 1984-. “Urban wetland structure and its relationship to exotic plants, biodiversity, and West Nile virus risk.” 2015. Web. 17 Jan 2021.
Vancouver:
Shappell, Laura Jean 1. Urban wetland structure and its relationship to exotic plants, biodiversity, and West Nile virus risk. [Internet] [Doctoral dissertation]. Rutgers University; 2015. [cited 2021 Jan 17].
Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/48651/.
Council of Science Editors:
Shappell, Laura Jean 1. Urban wetland structure and its relationship to exotic plants, biodiversity, and West Nile virus risk. [Doctoral Dissertation]. Rutgers University; 2015. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/48651/
Colorado State University
6.
Romo, Hannah Elizabeth.
Molecular analysis of the genetic determinants that contribute to virulence in lineage 2 West Nile virus.
Degree: PhD, Microbiology, Immunology, and Pathology, 2017, Colorado State University
URL: http://hdl.handle.net/10217/181331
► The ability of arboviruses to impart significant global disease burdens is related to the corresponding capacity of arboviruses to emerge in naïve environments or re-emerge…
(more)
▼ The ability of arboviruses to impart significant global disease burdens is related to the corresponding capacity of arboviruses to emerge in naïve environments or re-emerge in endemic environments. The introduction of
West Nile virus (WNV) into North America was marked by rapid spread across the continent, high rates of neuroinvasive disease in humans and horses, and subsequent displacement by newer evolved genotypes. In the last 12 years, an underrepresented lineage of WNV, lineage 2 (L2) has similarly emerged from sub-Saharan Africa into areas of Europe and Russia, causing widespread neurological disease and recurrent enzootic transmission. Given the potential for further geographic spread of L2 WNV and to understand mechanisms that drive emergence events for WNV, I sought to characterize L2 WNV in a comprehensive and comparative manner by investigating potential molecular mechanisms of pathogenesis in mosquitoes, birds, and mice (as models for human disease). A more thorough understanding of the mechanisms that dictate rapid dispersal and endemic maintenance of arboviruses will improve our ability to predict emergence events, increase the effectiveness of surveillance mechanisms, and develop effective intervention strategies. Within lineage 1 (L1) WNV, the role of the NS3-249P amino acid in modulating severe virogenesis in American Crows (AMCRs) has been well established and is predicted to be involved in facilitating the emergent capacity of L1 WNV. The evolution of a proline at the same NS3-249 locus in L2 WNV was initially observed during the first L2 WNV associated outbreak in Europe. However, no bird mortality was observed during the NS3-249P associated L2 WNV outbreak, and the extent of L2 WNV pathogenesis in birds is unclear. In this aim, I examined the viremia titers and mortality profiles of North American AMCRs and house sparrows following infection with African and European L2 WNV strains with and without amino acid mutations at the NS3-249 locus. Our results demonstrate that L2 WNV strains can elicit severe virogenic and fatal outcomes in AMCRs and HOSPs. Additionally, I found that the NS3-249 locus is modulating AMCR viremia titer outcomes, similar to what has been previously observed for the NS3-249 locus in L1 WNV strains. I also demonstrated the 3' UTR of NS10 reduces viremia titers of AMCRs at later time points. The vast majority of our understanding regarding the vector competence of Culex mosquitoes for WNV originates from studies performed with L1 WNV strains, and as such, little information is available regarding the competency of Culex mosquitoes for L2 WNV. To remediate this, I assessed the vector competence phenotypes of two different North American Culex mosquito species for multiple L2 WNV strains. Our results demonstrate that Culex pipiens and Culex quinquefasciatus mosquitoes can effectively transmit L2 WNV. I also identified a L2 strain harboring an NS3-249P mutation (NS10) that limited infection to the midgut of Culex pipiens mosquitoes. The competence of North American Culex…
Advisors/Committee Members: Ebel, Greg (advisor), Brault, Aaron (advisor), Blair, Carol (committee member), Bowen, Richard (committee member), Huyvaert, Kate (committee member).
Subjects/Keywords: lineage 2; West Nile virus
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Romo, H. E. (2017). Molecular analysis of the genetic determinants that contribute to virulence in lineage 2 West Nile virus. (Doctoral Dissertation). Colorado State University. Retrieved from http://hdl.handle.net/10217/181331
Chicago Manual of Style (16th Edition):
Romo, Hannah Elizabeth. “Molecular analysis of the genetic determinants that contribute to virulence in lineage 2 West Nile virus.” 2017. Doctoral Dissertation, Colorado State University. Accessed January 17, 2021.
http://hdl.handle.net/10217/181331.
MLA Handbook (7th Edition):
Romo, Hannah Elizabeth. “Molecular analysis of the genetic determinants that contribute to virulence in lineage 2 West Nile virus.” 2017. Web. 17 Jan 2021.
Vancouver:
Romo HE. Molecular analysis of the genetic determinants that contribute to virulence in lineage 2 West Nile virus. [Internet] [Doctoral dissertation]. Colorado State University; 2017. [cited 2021 Jan 17].
Available from: http://hdl.handle.net/10217/181331.
Council of Science Editors:
Romo HE. Molecular analysis of the genetic determinants that contribute to virulence in lineage 2 West Nile virus. [Doctoral Dissertation]. Colorado State University; 2017. Available from: http://hdl.handle.net/10217/181331
Université Montpellier II
7.
Bergaoui, Ramzi.
Epidémiologie de la maladie de West Nile en Tunisie : Epidemiology of West Nile disease in Tunisia.
Degree: Docteur es, Biologie Santé, 2012, Université Montpellier II
URL: http://www.theses.fr/2012MON20055
► Nous avons cherché à mieux comprendre la situation épidémiologique du virus West Nile (VWN) en Tunisie. Nous avons tout d'abord produit une carte du risque…
(more)
▼ Nous avons cherché à mieux comprendre la situation épidémiologique du virus West Nile (VWN) en Tunisie. Nous avons tout d'abord produit une carte du risque de transmission du VWN aux équidés montrant un risque élevé dans de nombreuses régions, dépendant de facteurs environnementaux : zones humides et climat favorables aux populations d'oiseaux sauvages et de moustiques. Le taux élevé de séroprévalence observé chez les équidés est compatible avec l'hypothèse d'une circulation endémique du VWN sans exclure la possibilité d'introductions répétées.Une étude complémentaire a démontré l'exposition des oiseaux domestiques, péri-domestiques et sauvages au VWN et a permis d'établir un premier inventaire des espèces d'oiseaux les plus exposées, pouvant servir de base à un système de surveillance de l'avifaune sauvage en Tunisie.Le suivi sérologique mensuel de poules sentinelles a permis de détecter la circulation du virus en fin de saison chaude (septembre, octobre) à proximité de zones humides pendant une période de forte activité des moustiques et d‘abondance des oiseaux sauvages. L'occurrence simultanée de cas humains de fièvre West Nile (FWN) laisse penser qu'un système de poules sentinelles serait utile pour une alerte précoce de recrudescence de l'activité du VWN.A l'issue de ce travail, nous proposons des pistes pour un système de surveillance multidisciplinaire de la FWN, adapté au contexte tunisien, et devant permettre la détection précoce de toute circulation virale.
Our investigations aimed at clarifying some aspects of the West Nile virus (WNV) epidemiological situation in Tunisia, and in particular at identifying areas at high risk of WNV circulation. A major achievement was the establishment of a risk map for the transmission of WNF in horses. This map shows that the risk of transmission strongly depends on environmental factors: increased risk associated to wetlands proximity and climatic factors favourable to wild birds and mosquitoes. The high seroprevalence observed in horses is compatible with an endemic circulation of WNV without excluding the possibility of repeated introductions.Another study in birds showed the exposure of domestic, wild resident and migratory birds to WNV, and helped establishing an initial inventory of bird species most exposed to WNV. These studies can serve as a basis for a monitoring system of wild birds in Tunisia.A system of monthly follow-up of sentinel chickens detected virus circulation at the end of the hot season (September, October), near wetlands and during a period of high mosquito activity, and abundance of wild birds. The simultaneous occurrence of human cases of WNF brought us to suggest that active surveillance in sentinel chickens would be useful for early warning of increased activity of WNV. This work allows us to propose trails for a WNV multidisciplinary monitoring system adapted to the Tunisian situation, enabling early detection of viral circulation.
Advisors/Committee Members: Lefrançois, Thierry (thesis director).
Subjects/Keywords: Virus; West nile; Épidémiologie; Tunisie; Virus; West Nile; Epidemiology; Tunisia
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Bergaoui, R. (2012). Epidémiologie de la maladie de West Nile en Tunisie : Epidemiology of West Nile disease in Tunisia. (Doctoral Dissertation). Université Montpellier II. Retrieved from http://www.theses.fr/2012MON20055
Chicago Manual of Style (16th Edition):
Bergaoui, Ramzi. “Epidémiologie de la maladie de West Nile en Tunisie : Epidemiology of West Nile disease in Tunisia.” 2012. Doctoral Dissertation, Université Montpellier II. Accessed January 17, 2021.
http://www.theses.fr/2012MON20055.
MLA Handbook (7th Edition):
Bergaoui, Ramzi. “Epidémiologie de la maladie de West Nile en Tunisie : Epidemiology of West Nile disease in Tunisia.” 2012. Web. 17 Jan 2021.
Vancouver:
Bergaoui R. Epidémiologie de la maladie de West Nile en Tunisie : Epidemiology of West Nile disease in Tunisia. [Internet] [Doctoral dissertation]. Université Montpellier II; 2012. [cited 2021 Jan 17].
Available from: http://www.theses.fr/2012MON20055.
Council of Science Editors:
Bergaoui R. Epidémiologie de la maladie de West Nile en Tunisie : Epidemiology of West Nile disease in Tunisia. [Doctoral Dissertation]. Université Montpellier II; 2012. Available from: http://www.theses.fr/2012MON20055
University of Georgia
8.
Ellis, Angela Elise.
The role of macrophages in the pathogenesis of West Nile virus in wild birds.
Degree: 2014, University of Georgia
URL: http://hdl.handle.net/10724/25173
► The major objective of this research was to further explore the pathogenesis of West Nile virus (WNV) in wild birds. Since it was first recognized…
(more)
▼ The major objective of this research was to further explore the pathogenesis of West Nile virus (WNV) in wild birds. Since it was first recognized in the United States in 1999, WNV has caused widespread mortality in birds. However, marked
differences in species susceptibility have been reported. Previous studies have suggested that macrophages may be a major target of the virus. Consequently, it was hypothesized that differences in macrophage function would explain differences in species
susceptibility. Specific aims included identification of susceptible species through passive surveillance, comparison of two different diagnostic methods (immunohistochemistry and virus isolation) for detection of WNV, description of gross and
histopathologic lesions in naturally and experimentally infected birds, characterization of the distribution of virus or viral antigen in tissues, description of viral kinetics in vitro and in vivo, and measurement of inflammatory mediators produced by
macrophages in vitro and in vivo. Passive surveillance suggested that corvids (crows and jays) were highly susceptible to infection and experienced high mortality. Other species such as rock doves had very low mortality. Both immunohistochemistry and
virus isolation were effective in diagnosis of WNV, and there was greater than 90% agreement between the two tests. Histologic lesions were often absent or nonspecific, and lesions did not correlate with presence or amount of viral antigen. Raptorial
species were examined in greater detail using histopathology, virus isolation, and immunohistochemistry. In raptors, WNV was primarily cardio- and neurotropic. Significant differences were noted between hawks and owls with owls tending to be less
severely affected. Red-tailed Hawks, Cooper’s Hawks, and Sharp-shinned Hawks were more commonly affected than other species.
Subjects/Keywords: West Nile virus; avian; immunohistochemistry; cytokines; macrophages
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Ellis, A. E. (2014). The role of macrophages in the pathogenesis of West Nile virus in wild birds. (Thesis). University of Georgia. Retrieved from http://hdl.handle.net/10724/25173
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Ellis, Angela Elise. “The role of macrophages in the pathogenesis of West Nile virus in wild birds.” 2014. Thesis, University of Georgia. Accessed January 17, 2021.
http://hdl.handle.net/10724/25173.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Ellis, Angela Elise. “The role of macrophages in the pathogenesis of West Nile virus in wild birds.” 2014. Web. 17 Jan 2021.
Vancouver:
Ellis AE. The role of macrophages in the pathogenesis of West Nile virus in wild birds. [Internet] [Thesis]. University of Georgia; 2014. [cited 2021 Jan 17].
Available from: http://hdl.handle.net/10724/25173.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Ellis AE. The role of macrophages in the pathogenesis of West Nile virus in wild birds. [Thesis]. University of Georgia; 2014. Available from: http://hdl.handle.net/10724/25173
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of North Texas
9.
Adiji, Olubu Adeoye.
Presence of Wolbachia, A Potential Biocontrol Agent: Screening for Vertebrate Blood Meal Source and West Nile Virus in Mosquitoes in the North Texas Region.
Degree: 2016, University of North Texas
URL: https://digital.library.unt.edu/ark:/67531/metadc862878/
► West Nile virus (WNV) is a geographically endemic mosquito-borne flavivirus that has spread across the United States infecting birds, mosquitos, humans, horses and other mammals.…
(more)
▼ West Nile virus (WNV) is a geographically endemic mosquito-borne flavivirus that has spread across the United States infecting birds, mosquitos, humans, horses and other mammals. The wide spread nature of this
virus is due to the ability of the mosquito vector to persist in broad, ecological diverse environments across the United States. In this study, mosquito populations in North Texas region were sampled for detection of Wolbachia, blood meal source, and WNV. The ultimate goal of this study was to examine the potential of a biocontrol agent, Wolbachia sp. that colonizes the hindgut of various insects, including mosquitos, as a natural means to interrupt
virus transmission from mosquitos to other hosts, including humans. In Australia, Wolbachia sp. from fruit flies (Drosophila melanogaster) have been successfully used to block transmission of a similar pathogenic
virus from mosquitos responsible for transmission of Dengue fever.
Here, mosquitoes were collected using CDC style Gravid Traps in Denton, Texas, from October 2012 through September 2014. Collected mosquitoes were identified, sexed, and categorized as to the amount of host blood in their alimentary system using a Zeiss Axio Zoom microscope (Carl Zeiss Microscopy, LLC, Thornwood, NY). Culex quinquefaciatus was the dominant blood engorged species collected. Smaller populations of Culex tarsalis and Aedes albopictus, another known vector for WNV were also collected. Mosquito larva were also collected from the UNT water research field station and reared to adults. Cx. tarsalis was the dominant mosquito taken from this habitat.
Samples of Cx. quinquefasciatus, Cx. tarsalis and A. albopictus were analyzed for Wolbachia sp. and to identify host blood in the mosquito alimentary system. Total DNA extraction from the pool of mosquito samples was by both commercially available DNA extraction kits (Qiagen, Valencia, CA) and salt extraction technique. Polymerase chain reaction (PCR) was used to amplify and identify Wolbachia sp. 16SrDNA and mitochondrial DNA from vertebrate blood. The maternally inherited endosymbiont, Wolbachia, were found to be uniformly distributed across the mosquitoes sampled in this study. Blood meal analysis by PCR showed that Cx. quinquefaciatus fed more on birds than on mammalian blood sources based on the previously developed primers used in this study.
Advisors/Committee Members: Goven, Arthur, Kennedy, James, Allen, Michael S..
Subjects/Keywords: Wolbachia; Mosquito; West Nile Virus; Culex quinquefaciatus
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
York University
10.
Yu, Don Wonchae.
The Effect of Temperature on West Nile Virus Transmission Dynamics.
Degree: PhD, Mathematics & Statistics, 2018, York University
URL: http://hdl.handle.net/10315/34560
► West Nile virus (WNV) is a vector-borne disease that first appeared in New York in 1999, then in Southern Ontario, Canada in 2002. Since its…
(more)
▼ West Nile virus (WNV) is a vector-borne disease that first appeared in New York in 1999, then in Southern Ontario, Canada in 2002. Since its arrival, WNV has rapidly spread across the North American continent to establish itself as a seasonal endemic infection. Among other environmental variables, temperature is the primary determinant of WNV transmission dynamics. In this dissertation, the relationship between temperature and WNV transmission dynamics is investigated and a single-season predictive model that explicitly accounts for temperature in various biological and epidemiological processes is proposed. First, we develop a mosquito abundance model where temperature is the driving force behind mosquito development, survival, and diapause. Then, the model is extended to include the WNV transmission cycle between mosquitoes and birds. Under simplifying assumptions, we derive an expression for the basic reproduction number and analyze its dependence on temperature. The transmission model was applied to the Peel Region in Southern Ontario for validation. Numerical results demonstrate the capacity of the model to capture the within-season trends of mosquito- and WNV- surveillance data. The proposed model can potentially be used as a real-time predictive tool to inform public health policy.
Advisors/Committee Members: Zhu, Huaiping (advisor), Madras, Neal (advisor).
Subjects/Keywords: Biology; Mosquito; Temperature; West Nile virus
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Yu, D. W. (2018). The Effect of Temperature on West Nile Virus Transmission Dynamics. (Doctoral Dissertation). York University. Retrieved from http://hdl.handle.net/10315/34560
Chicago Manual of Style (16th Edition):
Yu, Don Wonchae. “The Effect of Temperature on West Nile Virus Transmission Dynamics.” 2018. Doctoral Dissertation, York University. Accessed January 17, 2021.
http://hdl.handle.net/10315/34560.
MLA Handbook (7th Edition):
Yu, Don Wonchae. “The Effect of Temperature on West Nile Virus Transmission Dynamics.” 2018. Web. 17 Jan 2021.
Vancouver:
Yu DW. The Effect of Temperature on West Nile Virus Transmission Dynamics. [Internet] [Doctoral dissertation]. York University; 2018. [cited 2021 Jan 17].
Available from: http://hdl.handle.net/10315/34560.
Council of Science Editors:
Yu DW. The Effect of Temperature on West Nile Virus Transmission Dynamics. [Doctoral Dissertation]. York University; 2018. Available from: http://hdl.handle.net/10315/34560
Washington University in St. Louis
11.
Vasek, Michael John.
Mechanisms Underlying Memory Deficits Following West Nile Virus Neuroinvasive Disease.
Degree: PhD, Biology & Biomedical Sciences (Neurosciences), 2015, Washington University in St. Louis
URL: https://openscholarship.wustl.edu/art_sci_etds/688
► Neurocognitive sequelae are observed in >50% of patients who survive neuroinvasive infections with encephalitic arboviruses, such as the mosquito-borne West Nile virus (WNV). Early…
(more)
▼ Neurocognitive sequelae are observed in >50% of patients who survive neuroinvasive infections with encephalitic arboviruses, such as the mosquito-borne
West Nile virus (WNV). Early diagnosis and high survival rates from WNV neuroinvasive disease (WNND) (>90%) have thus led cumulatively to approximately ten thousand patients living with neurocognitive impairments, with 1-3000 cases accruing yearly, yet underlying mechanisms responsible for these deficits have not been investigated. Within the last 15 years, studies have begun uncover many pathways which are utilized both by the developing CNS as well as the immune system, including the use of cytokines in the regulation of progenitor cell proliferation and synaptic refinement via the classical complement cascade. Under healthy conditions, an intact blood-brain-barrier limits potential crosstalk between these domains. But amidst settings of CNS infection or damage, invocation of CNS developmental programs could be initiated by proinflammatory factors. With this in mind, the chapters of this thesis are centered around a theme of studying pathways utilized by both the immune system and the developing CNS and determining what the consequences are for cognition and memory during CNS
West Nile virus infection. First we have established a novel murine model of recovery from WNND in which intracranial inoculation of the attenuated mutant WNV-NS5-E218A leads to similar CNS viral loads and inflammation as peripheral inoculation of its parent strain, WNV-NY99, with rates of survival and cognitive dysfunction that mirror human WNND. WNV-NS5-E218A-recovered mice exhibit impaired spatial learning without significant alterations in cortical and hippocampal volume or total neuron numbers, but exhibit persistently activated microglia. Whole transcriptome analysis of hippocampi from WNV-NS5-E218A-recovered mice with poor spatial learning revealed increased expression of genes known to drive microglial effects on synaptic pruning, including the classical complement pathway and phagocytosis. Indeed, the classical complement cascade initiation factor, C1qA, was found to be produced primarily by microglia and localized to infected neurons and synapses during WNND. Electron and confocal microscopy revealed a loss of hippocampal mossy fiber synapses while synaptophysin-positive puncta and phagosomes containing synaptic vesicles were observed within microglia. This loss of mossy fiber synapses was also observed in human WNND post-mortem samples. Importantly, mice with fewer microglia (IL34 -/-) or mice deficient in complement (C3 -/-) were protected from WNV-induced synapse loss. This study provides a novel murine model of WNV-induced spatial memory impairment, provides evidence that viral infection of adult neurons may induce complement-mediated elimination of synapses, and identifies a potential mechanism underlying neurocognitive impairments experienced by patients recovering from WNND. Next we report that during WNND recovery, significantly fewer new granule cell…
Advisors/Committee Members: Robyn S Klein, John Cirrito, Michael Diamond, David Gutmann, Keiko Hirose.
Subjects/Keywords: Complement; Memory; Neurogenesis; West Nile Virus
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Vasek, M. J. (2015). Mechanisms Underlying Memory Deficits Following West Nile Virus Neuroinvasive Disease. (Doctoral Dissertation). Washington University in St. Louis. Retrieved from https://openscholarship.wustl.edu/art_sci_etds/688
Chicago Manual of Style (16th Edition):
Vasek, Michael John. “Mechanisms Underlying Memory Deficits Following West Nile Virus Neuroinvasive Disease.” 2015. Doctoral Dissertation, Washington University in St. Louis. Accessed January 17, 2021.
https://openscholarship.wustl.edu/art_sci_etds/688.
MLA Handbook (7th Edition):
Vasek, Michael John. “Mechanisms Underlying Memory Deficits Following West Nile Virus Neuroinvasive Disease.” 2015. Web. 17 Jan 2021.
Vancouver:
Vasek MJ. Mechanisms Underlying Memory Deficits Following West Nile Virus Neuroinvasive Disease. [Internet] [Doctoral dissertation]. Washington University in St. Louis; 2015. [cited 2021 Jan 17].
Available from: https://openscholarship.wustl.edu/art_sci_etds/688.
Council of Science Editors:
Vasek MJ. Mechanisms Underlying Memory Deficits Following West Nile Virus Neuroinvasive Disease. [Doctoral Dissertation]. Washington University in St. Louis; 2015. Available from: https://openscholarship.wustl.edu/art_sci_etds/688
Latrobe University
12.
Ambrose, Rebecca L.
Contributions of NS4A and the unfolded protein response during West Nile Virus replication.
Degree: PhD, 2013, Latrobe University
URL: http://hdl.handle.net/1959.9/496783
► Thesis (Ph.D.) - La Trobe University, 2013
Submission note: "A thesis submitted in total fulfillment of the requirements for the degree of Doctor of Philosophy…
(more)
Subjects/Keywords: West Nile virus.; Viruses Physiology.; Proteins.
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Ambrose, R. L. (2013). Contributions of NS4A and the unfolded protein response during West Nile Virus replication. (Doctoral Dissertation). Latrobe University. Retrieved from http://hdl.handle.net/1959.9/496783
Chicago Manual of Style (16th Edition):
Ambrose, Rebecca L. “Contributions of NS4A and the unfolded protein response during West Nile Virus replication.” 2013. Doctoral Dissertation, Latrobe University. Accessed January 17, 2021.
http://hdl.handle.net/1959.9/496783.
MLA Handbook (7th Edition):
Ambrose, Rebecca L. “Contributions of NS4A and the unfolded protein response during West Nile Virus replication.” 2013. Web. 17 Jan 2021.
Vancouver:
Ambrose RL. Contributions of NS4A and the unfolded protein response during West Nile Virus replication. [Internet] [Doctoral dissertation]. Latrobe University; 2013. [cited 2021 Jan 17].
Available from: http://hdl.handle.net/1959.9/496783.
Council of Science Editors:
Ambrose RL. Contributions of NS4A and the unfolded protein response during West Nile Virus replication. [Doctoral Dissertation]. Latrobe University; 2013. Available from: http://hdl.handle.net/1959.9/496783
University of Texas – Austin
13.
Fox-Baker, Daniel.
Mosquitoes and the urban environment : towards establishing a more sustainable planning framework for the control of mosquitoes and the health threats they may pose.
Degree: MSin Community and Regional Planning, Community and Regional Planning, 2014, University of Texas – Austin
URL: http://hdl.handle.net/2152/32247
► This paper delves into the issue of mosquito control strategies through an examination of present day issues and evaluates literature on administrative, technical, regulatory and…
(more)
▼ This paper delves into the issue of mosquito control strategies through an examination of present day issues and evaluates literature on administrative, technical, regulatory and professional practices involved in reducing exposure to mosquito borne diseases and how are their strategies tailored to specific contexts. The main issue that this paper will attempt to address is the development of a more sustainable framework for the control of mosquitoes and their respective health threats. In order to accomplish this, an examination is conducted with stakeholders involved in public health and mosquito control at local, state and national levels who can comment on their activities with authority. A list of interview questions tailored to different groups of stakeholders is utilized with the intent of eliciting data that answer to my research questions. Through this process, I am able to examine the current processes that are in use within such organizations and determine whether they are efficient, forward thinking and effective in addressing the myriad issues involved in proper mosquito control when compared to current literature on the
subject. It is expected that through this paper, a better understanding of the current mosquito control processes within L.A. and Houston will be developed resulting in the creation of better practices as a direct result of the investigation.
Advisors/Committee Members: Dooling, Sarah (advisor), Jha, Shalene (committee member).
Subjects/Keywords: Mosquito; West Nile Virus; Public health
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Fox-Baker, D. (2014). Mosquitoes and the urban environment : towards establishing a more sustainable planning framework for the control of mosquitoes and the health threats they may pose. (Masters Thesis). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/32247
Chicago Manual of Style (16th Edition):
Fox-Baker, Daniel. “Mosquitoes and the urban environment : towards establishing a more sustainable planning framework for the control of mosquitoes and the health threats they may pose.” 2014. Masters Thesis, University of Texas – Austin. Accessed January 17, 2021.
http://hdl.handle.net/2152/32247.
MLA Handbook (7th Edition):
Fox-Baker, Daniel. “Mosquitoes and the urban environment : towards establishing a more sustainable planning framework for the control of mosquitoes and the health threats they may pose.” 2014. Web. 17 Jan 2021.
Vancouver:
Fox-Baker D. Mosquitoes and the urban environment : towards establishing a more sustainable planning framework for the control of mosquitoes and the health threats they may pose. [Internet] [Masters thesis]. University of Texas – Austin; 2014. [cited 2021 Jan 17].
Available from: http://hdl.handle.net/2152/32247.
Council of Science Editors:
Fox-Baker D. Mosquitoes and the urban environment : towards establishing a more sustainable planning framework for the control of mosquitoes and the health threats they may pose. [Masters Thesis]. University of Texas – Austin; 2014. Available from: http://hdl.handle.net/2152/32247
McMaster University
14.
Lelic, Alina.
RELATIONSHIP BETWEEN CD8+ T CELL IMMUNITY AND AGING USING WEST NILE VIRUS INFECTION AS A MODEL.
Degree: PhD, 2013, McMaster University
URL: http://hdl.handle.net/11375/13514
► The incidence and severity of infectious diseases increases in elderly people (>60 years of age). It is believe that the age-associated changes in the…
(more)
▼ The incidence and severity of infectious diseases increases in elderly people (>60 years of age). It is believe that the age-associated changes in the immune system, termed immunosenescence, lead to diminished effectiveness of the immune system leaving the aged susceptible to infectious pathogens and associated diseases. The limited efficacy of the currently available vaccines in elderly populations contribute immensely to the frequency of infectious diseases in the globally growing aging population. As such, the demographic shift warrants the development of effective prophylactic vaccines for the elderly. West Nile virus (WNV) became endemic in North America in 1999, and although it infects people of all ages, the incidence of severe neuroinvasive disease is more prevalent in the elderly. I hypothesized that the susceptibility of the elderly towards severe WNV disease is a consequence of aberrant immune function, and specifically lack of functional virus-specific CD8+ T cells. Contrary to my hypothesis, I found that the magnitude, breadth and functionality of WNV-specific CD8+ T cells were not different between the age cohorts. These results argue that advanced age does not limit the development of functional CD8+ T cell responses following primary infections with an acute virus. Furthermore, the aged members of our cohort maintained functional CD8+ T cells to cytomegalovirus (CMV) and Epstein-Barr virus (EBV), common persistent viruses. Collectively, my results demonstrate that development of vaccines designed to elicit CD8+ T cell immunity may be warranted for elderly individuals and perhaps live vectors should be considered for this population.
Doctor of Philosophy (Medical Science)
Advisors/Committee Members: Bramson, Jonathan, Ken Rosenthal, Zhou Xing, Medical Sciences.
Subjects/Keywords: Hamilton; Immunosenescence; West Nile virus; Medical Immunology; Virus Diseases; Medical Immunology
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Lelic, A. (2013). RELATIONSHIP BETWEEN CD8+ T CELL IMMUNITY AND AGING USING WEST NILE VIRUS INFECTION AS A MODEL. (Doctoral Dissertation). McMaster University. Retrieved from http://hdl.handle.net/11375/13514
Chicago Manual of Style (16th Edition):
Lelic, Alina. “RELATIONSHIP BETWEEN CD8+ T CELL IMMUNITY AND AGING USING WEST NILE VIRUS INFECTION AS A MODEL.” 2013. Doctoral Dissertation, McMaster University. Accessed January 17, 2021.
http://hdl.handle.net/11375/13514.
MLA Handbook (7th Edition):
Lelic, Alina. “RELATIONSHIP BETWEEN CD8+ T CELL IMMUNITY AND AGING USING WEST NILE VIRUS INFECTION AS A MODEL.” 2013. Web. 17 Jan 2021.
Vancouver:
Lelic A. RELATIONSHIP BETWEEN CD8+ T CELL IMMUNITY AND AGING USING WEST NILE VIRUS INFECTION AS A MODEL. [Internet] [Doctoral dissertation]. McMaster University; 2013. [cited 2021 Jan 17].
Available from: http://hdl.handle.net/11375/13514.
Council of Science Editors:
Lelic A. RELATIONSHIP BETWEEN CD8+ T CELL IMMUNITY AND AGING USING WEST NILE VIRUS INFECTION AS A MODEL. [Doctoral Dissertation]. McMaster University; 2013. Available from: http://hdl.handle.net/11375/13514
Purdue University
15.
Chang, Jinsam.
Role of NS1 in virus replication using Dengue virus and West Nile virus chimeras.
Degree: MS, Biological Science, 2015, Purdue University
URL: https://docs.lib.purdue.edu/open_access_theses/1172
► The flavivirus non-structural protein 1 (NS1) is translocated into the endoplasmic reticulum (ER), glycosylated, and secreted from the infected cell. Among its various functions, a…
(more)
▼ The flavivirus non-structural protein 1 (NS1) is translocated into the endoplasmic reticulum (ER), glycosylated, and secreted from the infected cell. Among its various functions, a role of NS1 in RNA synthesis has been reported. The NS1 has three domains; “β-roll”, “wing” and “β-ladder (spaghetti loop)” domain. The characterization of the three domains of NS1 may help us to understand the multiple functions of NS1 in the context of specific regions of the protein. In this study, we have constructed chimeric Dengue/
West Nile (DENV/WNV) viruses, which each contain one of the three domains of NS1 from WNV in a DENV genetic background. The chimeras were characterized with respect to viral RNA synthesis, trans-complementation and virion assembly. It was observed that the β-roll chimera was impaired in RNA synthesis, leading to decreased production of viral particles. The reciprocal chimera, WNV/DENV β-roll chimera also showed a reduced level of replication. The spaghetti loop chimera was defective in viral RNA synthesis, and formed small plaques. The wing domain chimera did not show viral RNA synthesis. Remarkably this chimera was rescued by mutations in the wing domain. Collectively, the results indicate that these three domains have a role in viral RNA synthesis. The wing domain is not interchangeable between DENV and WNV for DENV RNA replication, while β-roll and spaghetti loop chimeras could support RNA synthesis.
Advisors/Committee Members: Richard Kuhn, Richard Kuhn, Cynthia Stauffacher, Jason Lanman.
Subjects/Keywords: chimera; Dengue Virus; Non structural protein 1; West Nile Virus
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Chang, J. (2015). Role of NS1 in virus replication using Dengue virus and West Nile virus chimeras. (Thesis). Purdue University. Retrieved from https://docs.lib.purdue.edu/open_access_theses/1172
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Chang, Jinsam. “Role of NS1 in virus replication using Dengue virus and West Nile virus chimeras.” 2015. Thesis, Purdue University. Accessed January 17, 2021.
https://docs.lib.purdue.edu/open_access_theses/1172.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Chang, Jinsam. “Role of NS1 in virus replication using Dengue virus and West Nile virus chimeras.” 2015. Web. 17 Jan 2021.
Vancouver:
Chang J. Role of NS1 in virus replication using Dengue virus and West Nile virus chimeras. [Internet] [Thesis]. Purdue University; 2015. [cited 2021 Jan 17].
Available from: https://docs.lib.purdue.edu/open_access_theses/1172.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Chang J. Role of NS1 in virus replication using Dengue virus and West Nile virus chimeras. [Thesis]. Purdue University; 2015. Available from: https://docs.lib.purdue.edu/open_access_theses/1172
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of New Mexico
16.
Pesko, Kendra.
Population dynamics of flaviviruses in the United States.
Degree: Biomedical Sciences Graduate Program, 2012, University of New Mexico
URL: https://digitalrepository.unm.edu/biom_etds/55
► The genus Flavivirus comprises viral species with positive sense, single stranded RNA genomes, most of which are transmitted by mosquitoes and ticks. During replication, RNA…
(more)
▼ The genus Flavivirus comprises viral species with positive sense, single stranded RNA genomes, most of which are transmitted by mosquitoes and ticks. During replication, RNA viruses have higher mutation rates than DNA viruses, because their virally encoded RNA dependent RNA polymerase has no proofreading activity. These viruses have been shown to exist within and between hosts as swarms of closely related mutant genomes that can be examined through sequence analysis. In the work presented here we focus on the population dynamics of two zoonotic flaviviruses that cause human morbidity and mortality in the United States: tick-borne Powassan
virus (POW) and mosquito-borne
West Nile virus (WNV). We examine the molecular epidemiology of POW, which has increased in incidence over the past ten years, and exists as two distinct lineages in the United States. We examine the sequence variants in WNV populations in different mosquito tissues to determine the influence of potential bottlenecks within mosquitoes on viral genetic variability. We also test influence of internally deleted WNV genomes isolated from naturally infected birds in NM on
virus growth and pathogenesis, both in vitro and in vivo. The primary goal of this work is to develop a better understanding of the underlying evolutionary pressures that influence arbovirus populations and lead to disease emergence.
Advisors/Committee Members: Ebel, Gregory, Hjelle, Brian, Hanley, Kathryn, Chackerian, Bryce, Panganiban, Antonito.
Subjects/Keywords: "West Nile virus; Powassan virus; Molecular epidemiology; vector borne disease"
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Pesko, K. (2012). Population dynamics of flaviviruses in the United States. (Doctoral Dissertation). University of New Mexico. Retrieved from https://digitalrepository.unm.edu/biom_etds/55
Chicago Manual of Style (16th Edition):
Pesko, Kendra. “Population dynamics of flaviviruses in the United States.” 2012. Doctoral Dissertation, University of New Mexico. Accessed January 17, 2021.
https://digitalrepository.unm.edu/biom_etds/55.
MLA Handbook (7th Edition):
Pesko, Kendra. “Population dynamics of flaviviruses in the United States.” 2012. Web. 17 Jan 2021.
Vancouver:
Pesko K. Population dynamics of flaviviruses in the United States. [Internet] [Doctoral dissertation]. University of New Mexico; 2012. [cited 2021 Jan 17].
Available from: https://digitalrepository.unm.edu/biom_etds/55.
Council of Science Editors:
Pesko K. Population dynamics of flaviviruses in the United States. [Doctoral Dissertation]. University of New Mexico; 2012. Available from: https://digitalrepository.unm.edu/biom_etds/55
Université Montpellier II
17.
Vittecoq, Marion.
Maladies infectieuses émergentes au sein des zones humides méditerranéennes dans le contexte des changements globaux : Climate changes and emerging infectious diseases in the Mediterranean wetlands.
Degree: Docteur es, Evolution, écologie, ressources génétiques, paléontologie, 2012, Université Montpellier II
URL: http://www.theses.fr/2012MON20269
► L'émergence de maladies telles que le SRAS et le SIDA au cours des dernières décennies a fait prendre conscience des liens étroits existant entre santé…
(more)
▼ L'émergence de maladies telles que le SRAS et le SIDA au cours des dernières décennies a fait prendre conscience des liens étroits existant entre santé animale, santé humaine et santé des écosystèmes. En effet, les pathogènes émergents ont pour la plupart une origine zoonotique (i.e. ils circulaient à l'origine au sein des populations animales). Les risques sanitaires associés à ces émergences sont en constante évolution sous l'influence des changements globaux qui modifient les écosystèmes et les contacts entre les hôtes. La prévention et le contrôle des maladies infectieuses émergentes nécessitent la compréhension de leur dynamique dans l'ensemble des compartiments dans lesquels elles circulent. Le travail présenté ici avait pour objectif d'améliorer cette compréhension au sein des zones humides méditerranéennes en ce concentrant sur deux pathogènes émergents : les virus Influenza A (VIA) et le virus West Nile. Il a été structuré selon trois axes de recherche : i) Utiliser la surveillance épidémiologique de l'avifaune sauvage pour comprendre la circulation du virus West Nile dans le bassin méditerranéen ii) Comprendre la dynamique des VIA au sein des différents compartiments où ils circulent et à leur interface iii) Comprendre le rôle des conditions environnementales dans la dynamique des VIA notamment au sein des populations humaines. Nos résultats mettent en évidence l'intérêt de mener des études multidisciplinaires sur le long terme pour comprendre l'épidémiologie des maladies émergentes. Ils soulignent également le rôle des activités anthropiques et des conditions environnementales dans la dynamique de ces maladies. Nos études apportent des éléments de réflexion pour allier gestion des risques d'émergence et gestion des écosystèmes et des populations. Elles encouragent à développer ce type d'approche afin de relever le défi de la prévention et du contrôle des pathogènes émergents.
During the last decades, the emergence of numerous infectious diseases such as SARS and AIDS has raised awareness of the close links that exist between animal health, human health and ecosystem health. Many of the emerging pathogens have a zoonotic origin (i.e. they originally circulated among animal populations). The health risks associated with the emergence of these diseases are progressing under the influence of global changes that affect ecosystems and contacts between hosts. The prevention and control of emerging infectious diseases require an in-depth understanding of their dynamics in all the compartments in which they occur. The aim of the present work is to improve our understanding of these phenomena within the context of Mediterranean wetlands by focusing on two emerging pathogens: Influenza A viruses (IAV) and West Nile virus. The thesis is structured around three research axes i) Using epidemiological surveillance of wild birds to investigate the circulation of West Nile virus in the Mediterranean Basin ii) Exploring IAV dynamics in the different compartments in which they circulate and at their interface iii)…
Advisors/Committee Members: Gauthier-Clerc, Michel (thesis director), Thomas, Frédéric (thesis director).
Subjects/Keywords: Maladies infectieuses; Influenza; Virus West Nile; Changements globaux; Méditerrannée; Infectious diseases; Influenza; West nile Virus; Global change; Mediterranean
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Vittecoq, M. (2012). Maladies infectieuses émergentes au sein des zones humides méditerranéennes dans le contexte des changements globaux : Climate changes and emerging infectious diseases in the Mediterranean wetlands. (Doctoral Dissertation). Université Montpellier II. Retrieved from http://www.theses.fr/2012MON20269
Chicago Manual of Style (16th Edition):
Vittecoq, Marion. “Maladies infectieuses émergentes au sein des zones humides méditerranéennes dans le contexte des changements globaux : Climate changes and emerging infectious diseases in the Mediterranean wetlands.” 2012. Doctoral Dissertation, Université Montpellier II. Accessed January 17, 2021.
http://www.theses.fr/2012MON20269.
MLA Handbook (7th Edition):
Vittecoq, Marion. “Maladies infectieuses émergentes au sein des zones humides méditerranéennes dans le contexte des changements globaux : Climate changes and emerging infectious diseases in the Mediterranean wetlands.” 2012. Web. 17 Jan 2021.
Vancouver:
Vittecoq M. Maladies infectieuses émergentes au sein des zones humides méditerranéennes dans le contexte des changements globaux : Climate changes and emerging infectious diseases in the Mediterranean wetlands. [Internet] [Doctoral dissertation]. Université Montpellier II; 2012. [cited 2021 Jan 17].
Available from: http://www.theses.fr/2012MON20269.
Council of Science Editors:
Vittecoq M. Maladies infectieuses émergentes au sein des zones humides méditerranéennes dans le contexte des changements globaux : Climate changes and emerging infectious diseases in the Mediterranean wetlands. [Doctoral Dissertation]. Université Montpellier II; 2012. Available from: http://www.theses.fr/2012MON20269
Université Paris-Sud – Paris XI
18.
Bahuon, Céline.
Construction d’un clone infectieux d’une souche méditerranéenne du Virus West Nile, validation de ses propriétés biologiques et développement de nouveaux modèles d’évaluation de la virulence : Construction of an infectious clone of a West Nile Mediterranean strain, validation of its biological properties and development of new models for the evaluation of virulence.
Degree: Docteur es, Microbiologie et thérapeutiques anti-infectieuses, 2012, Université Paris-Sud – Paris XI
URL: http://www.theses.fr/2012PA114828
► Le virus West Nile (VWN) est un virus neurotrope principalement transmis par piqûre de moustique et dont le réservoir est constitué par la faune aviaire…
(more)
▼ Le virus West Nile (VWN) est un virus neurotrope principalement transmis par piqûre de moustique et dont le réservoir est constitué par la faune aviaire sauvage. Les souches circulant en Europe appartiennent à 4 lignages génétiques différents à l’origine de nombreuses épidémies d’ampleur modérée à faible et limitées géographiquement, contrairement à ce qui a été observé en Amérique du Nord. En 1998 en Israël, une importante épidémie a a été associée pour la première fois à une forte mortalité de la faune aviaire sauvage. Le virus (souche IS-98-ST1, lignage 1a) a été isolé du cerveau d’une cigogne moribonde. L’objet de cette thèse a été de construire un clone infectieux de la souche IS-98-ST1 afin d’en explorer les propriétés de neuroinvasion et de pouvoir mettre en évidence les déterminants moléculaires de sa virulence.Le virus obtenu à partir de la construction clone infectieux s’est révélé posséder les mêmes propriétés biologiques que le virus parental, que ce soit in vitro sur cellules Vero ou in vivo sur souris sensibles ou résistantes ou encore sur l’embryon de poulet. L’embryon de poulet est présenté ici comme un nouveau modèle d’évaluation de la virulence du VWN. Un modèle cellulaire neuronale (lignée de neuroblastomes humains, SK-N-SH) est aussi évalué dans ce manuscrit. En conclusion, un nouvel outil de génétique inverse a été obtenu pour le VWN. Cet outil permettra de travailler sur l’impact de mutations ponctuelles, ou de modifications plus importantes touchant un ou plusieurs gènes viraux sur la virulence du VWN, spécifiquement dans le contexte européen.
West Nile virus (WNV) is a neurotropic virus mainly transmitted through mosquito bites. Wild birds represent the main reservoir hosts. Strains circulating in Europe belong to four lineages and have caused numerous but limited epidemics over the last few years. In 1998, an important outbreak associated to huge bird fatalities caused by a highly neuroinvasive strain (IS-98-ST1) took place in Israel. We aimed at producing a new infectious clone, based on the lineage 1a IS-98-ST1 WNV strain, for the characterization of its neuroinvasion properties as well as the molecular determinants of European WNV virulence. The growth kinetics of recombinant and parental WNV were similar in Vero cells. Moreover, the phenotypes of recombinant and parental WNV were indistinguishable in terms of viremia, viral load in the brain and mortality in susceptible and resistant mice. Finally, the pathobiology of the infectious clone was examined in embryonated chicken eggs, proposed as a new model for the evaluation of WNV virulence. The potential of human neuroblastoma cells (SK-N-SH) to discriminate between highly and mildly virulent WNV strains was assayed. In conclusion: a new molecular tool that is useful for the study of molecular determinants of WNV virulence has been generated. We take advantage of the high genetic stability of our one-piece infectious WNV cDNA clone to produce mutant viruses through the insertion of point mutations or the exchange of genetic fragments…
Advisors/Committee Members: Zientara, Stéphan (thesis director), Lecollinet, Sylvie (thesis director).
Subjects/Keywords: Virus West Nile; Clone infectieux; Déterminants moléculaires; Virulence; West Nile virus; Infectious clone; Molecular determinants; Virulence
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Bahuon, C. (2012). Construction d’un clone infectieux d’une souche méditerranéenne du Virus West Nile, validation de ses propriétés biologiques et développement de nouveaux modèles d’évaluation de la virulence : Construction of an infectious clone of a West Nile Mediterranean strain, validation of its biological properties and development of new models for the evaluation of virulence. (Doctoral Dissertation). Université Paris-Sud – Paris XI. Retrieved from http://www.theses.fr/2012PA114828
Chicago Manual of Style (16th Edition):
Bahuon, Céline. “Construction d’un clone infectieux d’une souche méditerranéenne du Virus West Nile, validation de ses propriétés biologiques et développement de nouveaux modèles d’évaluation de la virulence : Construction of an infectious clone of a West Nile Mediterranean strain, validation of its biological properties and development of new models for the evaluation of virulence.” 2012. Doctoral Dissertation, Université Paris-Sud – Paris XI. Accessed January 17, 2021.
http://www.theses.fr/2012PA114828.
MLA Handbook (7th Edition):
Bahuon, Céline. “Construction d’un clone infectieux d’une souche méditerranéenne du Virus West Nile, validation de ses propriétés biologiques et développement de nouveaux modèles d’évaluation de la virulence : Construction of an infectious clone of a West Nile Mediterranean strain, validation of its biological properties and development of new models for the evaluation of virulence.” 2012. Web. 17 Jan 2021.
Vancouver:
Bahuon C. Construction d’un clone infectieux d’une souche méditerranéenne du Virus West Nile, validation de ses propriétés biologiques et développement de nouveaux modèles d’évaluation de la virulence : Construction of an infectious clone of a West Nile Mediterranean strain, validation of its biological properties and development of new models for the evaluation of virulence. [Internet] [Doctoral dissertation]. Université Paris-Sud – Paris XI; 2012. [cited 2021 Jan 17].
Available from: http://www.theses.fr/2012PA114828.
Council of Science Editors:
Bahuon C. Construction d’un clone infectieux d’une souche méditerranéenne du Virus West Nile, validation de ses propriétés biologiques et développement de nouveaux modèles d’évaluation de la virulence : Construction of an infectious clone of a West Nile Mediterranean strain, validation of its biological properties and development of new models for the evaluation of virulence. [Doctoral Dissertation]. Université Paris-Sud – Paris XI; 2012. Available from: http://www.theses.fr/2012PA114828
University of Illinois – Chicago
19.
Matzke, Hannah.
Urbanization, Land Cover, Weather, and Incidence Rates of Neuroinvasive West Nile Virus Infection.
Degree: 2016, University of Illinois – Chicago
URL: http://hdl.handle.net/10027/21337
► The first case of human West Nile Virus (WNV) in Illinois was reported in 2002, and infections have been reported in Illinois every year since.…
(more)
▼ The first case of human
West Nile Virus (WNV) in Illinois was reported in 2002, and infections have been reported in Illinois every year since. Many human infections are asymptomatic, but some exhibit flu-like symptoms, and the most severe infections become neuroinvasive and can be fatal. The transmission cycle is maintained between Culex mosquitoes and passerine birds, humans and horses are incidental hosts. Both birds and mosquitoes have preferred habitats and regional species variations; life cycle and behavioral patterns can be influenced by weather. Urban environments allow for close proximity of humans and mosquitoes, and may create microenvironments that are suitable habitats for mosquito populations to flourish. The aim of this study is to understand the associations of human neuroinvasive WNV infections and urbanization, weather, and land cover in Illinois using a multivariate model. These relationships are important to understand to assess the impact of climate change on future WNV transmission.
Advisors/Committee Members: Dorevitch, Samuel (advisor), Dworkin, Mark (committee member), Friedman, Lee (committee member).
Subjects/Keywords: West Nile Virus; Neuroinvasive West Nile Virus; Temperature; Precipitation; Land Cover; Developed Land; Weather; Climate; Climate Change; BRACE Illinois; Culex
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Matzke, H. (2016). Urbanization, Land Cover, Weather, and Incidence Rates of Neuroinvasive West Nile Virus Infection. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/21337
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Matzke, Hannah. “Urbanization, Land Cover, Weather, and Incidence Rates of Neuroinvasive West Nile Virus Infection.” 2016. Thesis, University of Illinois – Chicago. Accessed January 17, 2021.
http://hdl.handle.net/10027/21337.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Matzke, Hannah. “Urbanization, Land Cover, Weather, and Incidence Rates of Neuroinvasive West Nile Virus Infection.” 2016. Web. 17 Jan 2021.
Vancouver:
Matzke H. Urbanization, Land Cover, Weather, and Incidence Rates of Neuroinvasive West Nile Virus Infection. [Internet] [Thesis]. University of Illinois – Chicago; 2016. [cited 2021 Jan 17].
Available from: http://hdl.handle.net/10027/21337.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Matzke H. Urbanization, Land Cover, Weather, and Incidence Rates of Neuroinvasive West Nile Virus Infection. [Thesis]. University of Illinois – Chicago; 2016. Available from: http://hdl.handle.net/10027/21337
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Alberta
20.
Xu, Zaikun.
Functional Analyses of West Nile virus-Host
Interactions.
Degree: PhD, Department of Cell Biology, 2013, University of Alberta
URL: https://era.library.ualberta.ca/files/1n79h534r
► West Nile virus (WNV) is a neurotropic, blood-borne flavivirus that can cause serious neurological disease in humans and animals. While significant progress has been made…
(more)
▼ West Nile virus (WNV) is a neurotropic, blood-borne
flavivirus that can cause serious neurological disease in humans
and animals. While significant progress has been made in
identifying virus-encoded pathogenic determinants, very little is
known regarding how these viral proteins interact with host cell
proteins. Recent evidence suggests that in addition to its
structural role in packaging genomic RNA, the WNV capsid protein
plays important roles in virus host interactions and therefore,
characterizing the interactions between capsid and cellular
proteins should contribute to our understanding of WNV disease and
may even reveal targets for antiviral therapy. Through an extensive
yeast two-hybrid screen, I identified DDX56, a novel WNV
capsid-interacting nucleolar RNA helicase. Experimental analyses
revealed DDX56 is not required for production of viral RNA or
proteins, however, WNV virions secreted from DDX56-depleted cells
are 100 times less infectious than those produced in normal cells.
Collectively, these data suggest that DDX56 is critical for
assembly of infectious WNV virions possibly by facilitating the
packaging of viral RNA. I also investigated how WNV infection
affects tight junctions in polarized cells with the goal of
understanding how the virus breaches the blood-brain barrier to
gain access to the central nervous system. While a number of recent
studies have documented that WNV infection negatively impacts the
barrier function of tight junctions, the intracellular mechanism by
which this occurs is poorly understood. Using a coordinated
approach to understand the direct effects of WNV infection on tight
junction proteins in both epithelial and endothelial cells, I
discovered that WNV infection results in endocytosis of a specific
subset of tight junction membrane proteins including claudin-1 and
JAM-1 followed by microtubule-based transport to and degradation in
lysosomes. Further studies into this process could lead to
therapeutic treatments that block viral spread and/or design of
attenuated vaccine strains.
Subjects/Keywords: Virus-Host interactions; Endocytosis; DDX56; Capsid; Virus assembly; Tight junction; West Nile virus; RNA helicase
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Xu, Z. (2013). Functional Analyses of West Nile virus-Host
Interactions. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/1n79h534r
Chicago Manual of Style (16th Edition):
Xu, Zaikun. “Functional Analyses of West Nile virus-Host
Interactions.” 2013. Doctoral Dissertation, University of Alberta. Accessed January 17, 2021.
https://era.library.ualberta.ca/files/1n79h534r.
MLA Handbook (7th Edition):
Xu, Zaikun. “Functional Analyses of West Nile virus-Host
Interactions.” 2013. Web. 17 Jan 2021.
Vancouver:
Xu Z. Functional Analyses of West Nile virus-Host
Interactions. [Internet] [Doctoral dissertation]. University of Alberta; 2013. [cited 2021 Jan 17].
Available from: https://era.library.ualberta.ca/files/1n79h534r.
Council of Science Editors:
Xu Z. Functional Analyses of West Nile virus-Host
Interactions. [Doctoral Dissertation]. University of Alberta; 2013. Available from: https://era.library.ualberta.ca/files/1n79h534r
University of Pretoria
21.
[No author].
Molecular characterization of South African lineage II
West Nile virus isolates and development of a diagnostic
assay
.
Degree: 2008, University of Pretoria
URL: http://upetd.up.ac.za/thesis/available/etd-06122008-130924/
► West Nile virus (WNV) belongs to the Flaviviridae family, a virus family of which many members are known as human pathogens. WNV has a worldwide…
(more)
▼ West Nile virus (WNV) belongs to the Flaviviridae
family, a
virus family of which many members are known as human
pathogens. WNV has a worldwide distribution and strains that
cluster in lineage II is endemic to sub-Saharan Africa. The
complete nucleotide sequence of four lineage II
West Nile virus
strains, isolated in South Africa from patients with mild or severe
WNV infections, were determined. Using a murine model, these
strains had been shown to produce either highly or less
neuroinvasive infections and induced similar genes to corresponding
highly or less neuroinvasive lineage I strains. Nucleotide and
amino acid sequence comparison between highly and less pathogenic
lineage II strains demonstrated that the non-structural genes and
in particular the gene coding for the NS5 proteins were the most
variable. All the lineage II strains sequenced in this study were
found to possess the E-protein glycosylation site previously
postulated to be associated with virulence. Comparison of the
signalase cleavage sites suggested that lineage II strains may be
cleaved slightly more efficiently than lineage I strains in the
C-prM junction, but less efficiently between prM and E genes.
Relative to the highly neuroinvasive strains sequenced in this
study major deletions were found in the 3’ noncoding region of 2
lineage II strains shown in previous studies to be either less- or
not at all neuroinvasive. This is the first report of full genome
sequences of highly neuroinvasive lineage II WNV strains. Currently
available commercial WNV ELISA kits were developed with lineage I
WNV strains and are expensive to use. For these reasons the
development of a potential ELISA diagnostic assay based on the
South African lineage II strain, H442, was envisaged. Such assay,
if reliable and efficacious would be a useful tool towards WNV
surveillance. The prM and E genes were selected to be expressed as
recombinant antigens because of their co-expression nature and
because the envelope protein is the principal target for
neutralization. After cloning of the respective genes and
verification of integrity, a mammalian expression system was
utilized. Different mammalian cells and transfection media were
tested and BHK 21 cells with SuperFect transfection medium were
found to be best. Attempted expression of proteins was tested with
immunofluorescent antibody testing as well as SDS-PAGE and Western
blot analysis. Expression of recombinant WNV antigens were also
tested in indirect and sandwich ELISA’s systems. It was however not
possible to perform these two ELISA systems at a satisfactory level
or clearly indicated if expression of proteins was
successful.
Advisors/Committee Members: Prof L H Nel (advisor), Dr W Markotter (advisor), Dr J Paweska (advisor), Dr M Venter (advisor).
Subjects/Keywords: South africa;
West nile virus;
Infections;
Molecular;
UCTD
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
author], [. (2008). Molecular characterization of South African lineage II
West Nile virus isolates and development of a diagnostic
assay
. (Masters Thesis). University of Pretoria. Retrieved from http://upetd.up.ac.za/thesis/available/etd-06122008-130924/
Chicago Manual of Style (16th Edition):
author], [No. “Molecular characterization of South African lineage II
West Nile virus isolates and development of a diagnostic
assay
.” 2008. Masters Thesis, University of Pretoria. Accessed January 17, 2021.
http://upetd.up.ac.za/thesis/available/etd-06122008-130924/.
MLA Handbook (7th Edition):
author], [No. “Molecular characterization of South African lineage II
West Nile virus isolates and development of a diagnostic
assay
.” 2008. Web. 17 Jan 2021.
Vancouver:
author] [. Molecular characterization of South African lineage II
West Nile virus isolates and development of a diagnostic
assay
. [Internet] [Masters thesis]. University of Pretoria; 2008. [cited 2021 Jan 17].
Available from: http://upetd.up.ac.za/thesis/available/etd-06122008-130924/.
Council of Science Editors:
author] [. Molecular characterization of South African lineage II
West Nile virus isolates and development of a diagnostic
assay
. [Masters Thesis]. University of Pretoria; 2008. Available from: http://upetd.up.ac.za/thesis/available/etd-06122008-130924/
Universiteit Utrecht
22.
Jonquière, F.J.
West NileVirus Vaccination: IgM and IgG responses in horses after injection in Different Muscles & The Prevalence of MRSA in healthy horses in the Netherlands: a follow-up study.
Degree: 2008, Universiteit Utrecht
URL: http://dspace.library.uu.nl:8080/handle/1874/183163
► West Nile Virus Vaccination: West Nile Virus (WNV) may cause severe symptoms in birds, horses and humans. WNV is not (yet) present in the Netherlands,…
(more)
▼ West Nile Virus Vaccination:
West Nile Virus (WNV) may cause severe symptoms in birds, horses and humans. WNV is not (yet) present in the Netherlands, but it is steadily approaching from south-eastern Europe. Recently, a WNV-vaccine (Duvaxyn®-WNV) became available in Europe. It is claimed that vaccination results solely in an IgG response making it possible to differentiate acutely-infected horses from vaccinated horses by using an IgM-based ELISA. The aims of the study were to investigate this claim and to evaluate whether different intramuscular injection sites influence the immunological responses and whether any local or systemic adverse reactions would occur.
Twenty horses, 3 to 21 years old, were vaccinated twice (day 0 and 21) in different muscle groups. Weekly blood samples were collected over a period of 42 days and tested for Flavivirus IgM antibodies using a WNV-IgM ELISA and for Flavivirus Ig antibodies using a WNV blocking ELISA.
None of the horses tested positive for WNV antibodies on Day 0. No side effects were found following any of the intramuscular injections.
Location of the intramuscular injections showed no significant effect on the immunogenic response.
All horses showed a clear Ig (total antibody) response to the WNV vaccination, but in two horses this response was limited. Surprisingly, ten horses gave also a (limited) positive IgM response. This indicates that an IgM capture ELISA is not reliable to diagnose acute WNV infections in recently vaccinated horses.
MRSA:
Methicillin resistant Staphylococcus aureus (MRSA) is considered to be an increasing problem in hospitalized horses in the Netherlands. In 2008, 24 of 259 horses admitted to a veterinary hospital tested positive (1), while in a study in 2005, 200 randomly selected ostensibly healthy horses all tested negative for MRSA (2). This raised the question as to whether the high percentage of MRSA-positive horses reflected an overall increase in the population or was a product of the selection of the referral horses. The aim of the present study was to perform a follow-up screening of the 200 horses tested previously in the 2005 study. Of the horses screened in 2005, only 48 were still accessible (11 different premises). These horses were sampled with an additional 54 horses selected randomly at 6 other premises. Two nasal swabs were collected from each horse and incubated in two different selective media: one method similar to the study in 2005 (2) and one more sensitive method that is now used as a standard and has been used in the study of the referral horses (1). All 102 horses tested negative for MRSA using both isolation methods. No MRSA was found in the 102 healthy horses tested in the Netherlands. Further studies are needed to establish whether specific risk factors for testing MRSA-positive can be identified in the group of referred horses.
Advisors/Committee Members: Sloet van Oldruitenborgh-Oosterbaan, M.M., Duijkeren, E. van, Wagenaar, J..
Subjects/Keywords: Diergeneeskunde; West Nile Virus, Vaccination response, ELISA, MRSA, Staphylococcus Aureus
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Jonquière, F. J. (2008). West NileVirus Vaccination: IgM and IgG responses in horses after injection in Different Muscles & The Prevalence of MRSA in healthy horses in the Netherlands: a follow-up study. (Doctoral Dissertation). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/183163
Chicago Manual of Style (16th Edition):
Jonquière, F J. “West NileVirus Vaccination: IgM and IgG responses in horses after injection in Different Muscles & The Prevalence of MRSA in healthy horses in the Netherlands: a follow-up study.” 2008. Doctoral Dissertation, Universiteit Utrecht. Accessed January 17, 2021.
http://dspace.library.uu.nl:8080/handle/1874/183163.
MLA Handbook (7th Edition):
Jonquière, F J. “West NileVirus Vaccination: IgM and IgG responses in horses after injection in Different Muscles & The Prevalence of MRSA in healthy horses in the Netherlands: a follow-up study.” 2008. Web. 17 Jan 2021.
Vancouver:
Jonquière FJ. West NileVirus Vaccination: IgM and IgG responses in horses after injection in Different Muscles & The Prevalence of MRSA in healthy horses in the Netherlands: a follow-up study. [Internet] [Doctoral dissertation]. Universiteit Utrecht; 2008. [cited 2021 Jan 17].
Available from: http://dspace.library.uu.nl:8080/handle/1874/183163.
Council of Science Editors:
Jonquière FJ. West NileVirus Vaccination: IgM and IgG responses in horses after injection in Different Muscles & The Prevalence of MRSA in healthy horses in the Netherlands: a follow-up study. [Doctoral Dissertation]. Universiteit Utrecht; 2008. Available from: http://dspace.library.uu.nl:8080/handle/1874/183163
Cornell University
23.
DeCarlo, Christine.
The Epidemiological Risk Assessment Of West Nile Virus In New York State.
Degree: PhD, Zoology, 2011, Cornell University
URL: http://hdl.handle.net/1813/33497
► Epidemiology is a holistic investigation of factors affecting the health and illness of populations. The goal of this study was to assess different risk factors…
(more)
▼ Epidemiology is a holistic investigation of factors affecting the health and illness of populations. The goal of this study was to assess different risk factors related to
West Nile virus (WNV) in New York State (NYS). WNV first appeared here in 1999 and is now considered endemic in NYS. The factors that play a role in the perpetuation of the
virus are not fully understood. We studied a known host, a possible vector, and two other possible hosts. Our study encompassed the risk factors of crows in Tompkins County, the role of non-Culex species mosquitoes in Tompkins, Nassau, and Suffolk Counties, the possible component of dairy cattle in the New York City Watershed (Delaware County), and the element of mesopredators in Nassau and Suffolk Counties.
Advisors/Committee Members: Mohammed, Hussni Omar (chair), Harrington, Laura C. (committee member), Glaser, Amy L (committee member), Chang, Yung-Fu (committee member).
Subjects/Keywords: West Nile virus; arbovirus; risk factors; zoonosis; epidemiology
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
DeCarlo, C. (2011). The Epidemiological Risk Assessment Of West Nile Virus In New York State. (Doctoral Dissertation). Cornell University. Retrieved from http://hdl.handle.net/1813/33497
Chicago Manual of Style (16th Edition):
DeCarlo, Christine. “The Epidemiological Risk Assessment Of West Nile Virus In New York State.” 2011. Doctoral Dissertation, Cornell University. Accessed January 17, 2021.
http://hdl.handle.net/1813/33497.
MLA Handbook (7th Edition):
DeCarlo, Christine. “The Epidemiological Risk Assessment Of West Nile Virus In New York State.” 2011. Web. 17 Jan 2021.
Vancouver:
DeCarlo C. The Epidemiological Risk Assessment Of West Nile Virus In New York State. [Internet] [Doctoral dissertation]. Cornell University; 2011. [cited 2021 Jan 17].
Available from: http://hdl.handle.net/1813/33497.
Council of Science Editors:
DeCarlo C. The Epidemiological Risk Assessment Of West Nile Virus In New York State. [Doctoral Dissertation]. Cornell University; 2011. Available from: http://hdl.handle.net/1813/33497
Colorado State University
24.
Schurich, Jessica.
Modeling Culex tarsalis Coquillett abundance on the northern Colorado Front Range using a landscape-level approach.
Degree: MS(M.S.), Bioagricultural Sciences and Pest Management, 2012, Colorado State University
URL: http://hdl.handle.net/10217/75116
► Endemic and emerging vector-borne diseases are major health problems, and some of them are unlikely to be eliminated regardless of control efforts. The applications for…
(more)
▼ Endemic and emerging vector-borne diseases are major health problems, and some of them are unlikely to be eliminated regardless of control efforts. The applications for remote sensing and Geographic Information System (GIS) data include the identification of larval mosquito habitats and forecasting of species distribution and abundance, thereby improving the ability to target control efforts to reduce the risk of transmission of vector-borne pathogens. The practicality for the incorporation of remotely sensed environmental data into a GIS has greatly enhanced the understanding for the spatial and temporal distribution patterns of vectors, thereby enabling improved vector control operations and disease management response. Since the initial detection of
West Nile virus (WNV) in Colorado in 2002, the northern part of the Colorado Front Range has come to be recognized as a high-risk area for WNV infections in humans, with 7.5% of the national cases of WNV being reported from Boulder, Weld and Larimer counties during 2003-2011. Culex tarsalis Coquillett is recognized as the primary species of concern in the transmission of WNV to humans along the northern Colorado Front Range. Before implementing the tools needed to control the spread of a vector-borne disease, public health agencies and organization officials must consider the spatial and temporal factors which are driving the interactions between the pathogen, the vertebrate host(s), and the vector(s). A sound understanding of the vector biology will vastly improve the efficacy for its control. Previous research performed on the northern Colorado Front Range used National Land Cover Data (NLCD) and IKONOS satellite imagery to model adult mosquito abundance of Cx. tarsalis. I applied a landscape-level approach to elucidate the effects of landscape-level environmental factors (independent or predictor variables) at multiple spatial extents on monthly adult Cx. tarsalis abundance (dependent variable) in Fort Collins, Loveland and Johnstown, Colorado using GIS technology. Multiple regression models provided empirical evidence for the seasonal variability in adult Cx. tarsalis populations. A more detailed representation for the importance of spatial extent for elevation, slope, distance to and area of irrigated lands and the distance to larval mosquito sites was obtained from this study. Multiple regression models developed using stepAIC were able to explain and forecast monthly adult mosquito abundance with accuracies ranging from 43%-73% in Fort Collins and 36%-68% in Loveland and Johnstown. The expression of environmental variables also differed by month and year. Mean elevation within a 500 m buffer of mosquito trap locations in Fort Collins were negatively correlated with mean monthly adult Cx. tarsalis abundance. A positive relationship existed between mean monthly adult Cx. tarsalis abundance in Fort Collins and the perimeter of larval mosquito habitats within a 1.0 km buffer of traps and the distance to irrigated lands at a spatial extent of 500 m around traps. Mean…
Advisors/Committee Members: Kondratieff, Boris (advisor), Kumar, Sunil (advisor), Moore, Chester (committee member), Eisen, Lars (committee member).
Subjects/Keywords: Colorado; GIS; landscape; Culex tarsalis; West Nile virus
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Schurich, J. (2012). Modeling Culex tarsalis Coquillett abundance on the northern Colorado Front Range using a landscape-level approach. (Masters Thesis). Colorado State University. Retrieved from http://hdl.handle.net/10217/75116
Chicago Manual of Style (16th Edition):
Schurich, Jessica. “Modeling Culex tarsalis Coquillett abundance on the northern Colorado Front Range using a landscape-level approach.” 2012. Masters Thesis, Colorado State University. Accessed January 17, 2021.
http://hdl.handle.net/10217/75116.
MLA Handbook (7th Edition):
Schurich, Jessica. “Modeling Culex tarsalis Coquillett abundance on the northern Colorado Front Range using a landscape-level approach.” 2012. Web. 17 Jan 2021.
Vancouver:
Schurich J. Modeling Culex tarsalis Coquillett abundance on the northern Colorado Front Range using a landscape-level approach. [Internet] [Masters thesis]. Colorado State University; 2012. [cited 2021 Jan 17].
Available from: http://hdl.handle.net/10217/75116.
Council of Science Editors:
Schurich J. Modeling Culex tarsalis Coquillett abundance on the northern Colorado Front Range using a landscape-level approach. [Masters Thesis]. Colorado State University; 2012. Available from: http://hdl.handle.net/10217/75116
Texas A&M University
25.
Wittich, Courtney Anne.
Spatial analysis of West Nile Virus and predictors of hyperendemicity in the Texas equine industry.
Degree: MS, Epidemiology, 2009, Texas A&M University
URL: http://hdl.handle.net/1969.1/ETD-TAMU-2074
► West Nile Virus (WNV) first appeared in Texas equids during June 2002. It has since spread rapidly across the state and apparently become endemic. Data…
(more)
▼ West Nile Virus (WNV) first appeared in Texas equids during June 2002. It has
since spread rapidly across the state and apparently become endemic. Data from
outbreaks occurring between 2002 and 2004 were analyzed to determine hotspots of
equine WNV disease, identify environmental factors associated with outbreaks, and to
create risk maps of locations with horses at a higher risk of the disease. Kriging was used
to model the smoothed WNV attack rates, and interpolated rates were mapped to describe
the spatial distribution of WNV disease risk in Texas. A retrospective time-space
analysis using a Poisson model was conducted on each year’s data to identify clusters
with high attack rates. The resulting overlapping yearly clusters were considered areas of
hyperendemicity (hotspots). The counties identified as hotspots included Hockley,
Lubbock, and Lynn (primary cluster) and Leon and Roberstson (secondary cluster).
Environmental and geographic features were added to the disease maps and analyzed to
determine possible environmental factors associated with outbreaks. Locations in close
proximity to lakes, bird breeding routes, migratory flyway zones, crop farm and
agricultural land, and all dense vegetation were found to be important environmental predictors. Finally, risk maps were created that combined surveillance data on WNV
positive mosquito collections and wild bird WNV cases with previously identified
environmental risk factors to predict areas of high occurrence of WNV. These risk maps
could be used to implement various preventative measures to reduce the transmission of
WNV in the Texas equine industry.
Advisors/Committee Members: Michael, Ward P. (advisor), Fosgate, Geoff (committee member), Srinivasan, R. (committee member).
Subjects/Keywords: West Nile Virus; Spatial Epidemiology
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Wittich, C. A. (2009). Spatial analysis of West Nile Virus and predictors of hyperendemicity in the Texas equine industry. (Masters Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/ETD-TAMU-2074
Chicago Manual of Style (16th Edition):
Wittich, Courtney Anne. “Spatial analysis of West Nile Virus and predictors of hyperendemicity in the Texas equine industry.” 2009. Masters Thesis, Texas A&M University. Accessed January 17, 2021.
http://hdl.handle.net/1969.1/ETD-TAMU-2074.
MLA Handbook (7th Edition):
Wittich, Courtney Anne. “Spatial analysis of West Nile Virus and predictors of hyperendemicity in the Texas equine industry.” 2009. Web. 17 Jan 2021.
Vancouver:
Wittich CA. Spatial analysis of West Nile Virus and predictors of hyperendemicity in the Texas equine industry. [Internet] [Masters thesis]. Texas A&M University; 2009. [cited 2021 Jan 17].
Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2074.
Council of Science Editors:
Wittich CA. Spatial analysis of West Nile Virus and predictors of hyperendemicity in the Texas equine industry. [Masters Thesis]. Texas A&M University; 2009. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2074
Texas A&M University
26.
Berhane, Stephen.
The Role of Climatic and Environmental Variability on West Nile Virus in Harris County, Texas, 2006-2007.
Degree: MS, Geography, 2010, Texas A&M University
URL: http://hdl.handle.net/1969.1/ETD-TAMU-2009-05-794
► Between the years 2006-2007, Harris County, located at the heart of the Houston metropolitan area, experienced a nearly 90% decline in the number of female…
(more)
▼ Between the years 2006-2007, Harris County, located at the heart of the
Houston metropolitan area, experienced a nearly 90% decline in the number of female
mosquitoes which tested positive for the
West Nile virus. Different theories exist as to
why such a precipitous drop occurred and this study attempts to determine the extent to
which climatic variability between the two years played a role. The Mosquito Control
Division of Harris County Public Health and Environmental Services gathered the data
on vectors and reservoirs. Then using GIS, spatial analysis, and geostatistical tools the
vector and reservoir data was compared to climatic data to investigate any changes in
viral distribution.
Previous studies of the area until now have used a limited amount of climatic
data; this study seeks to improve the resolution of climatic data analyzed. A higher
resolution of data was achieved by including as-of-yet unused data from a network of
over 150 gauges maintained by various state and local agencies in addition to
previously used data from NOAA COOP stations. Using this dense network of station's
values for precipitation, temperature and other climatic variables were interpolated for
all of Harris County and used in the analysis. Based on results, water availability was the most likely out of all the climatic
variables to the precipitous drop of
West Nile virus positive female mosquitoes from
2006-2007. Correlations between all climatic variables and mosquito abundance and
West Nile virus positives showed mixed results compared to a previous study in the
same area.
Advisors/Committee Members: Sui, Daniel (advisor), Liu, Hongxing (committee member), Slotman, Michel (committee member).
Subjects/Keywords: Medical geography; West Nile virus
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Berhane, S. (2010). The Role of Climatic and Environmental Variability on West Nile Virus in Harris County, Texas, 2006-2007. (Masters Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/ETD-TAMU-2009-05-794
Chicago Manual of Style (16th Edition):
Berhane, Stephen. “The Role of Climatic and Environmental Variability on West Nile Virus in Harris County, Texas, 2006-2007.” 2010. Masters Thesis, Texas A&M University. Accessed January 17, 2021.
http://hdl.handle.net/1969.1/ETD-TAMU-2009-05-794.
MLA Handbook (7th Edition):
Berhane, Stephen. “The Role of Climatic and Environmental Variability on West Nile Virus in Harris County, Texas, 2006-2007.” 2010. Web. 17 Jan 2021.
Vancouver:
Berhane S. The Role of Climatic and Environmental Variability on West Nile Virus in Harris County, Texas, 2006-2007. [Internet] [Masters thesis]. Texas A&M University; 2010. [cited 2021 Jan 17].
Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2009-05-794.
Council of Science Editors:
Berhane S. The Role of Climatic and Environmental Variability on West Nile Virus in Harris County, Texas, 2006-2007. [Masters Thesis]. Texas A&M University; 2010. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2009-05-794
27.
Roldan, Josiah Javier.
West Nile virus : forecasting models for a resurging vector-borne disease in Arizona, U.S.A.
Degree: PhD, Public Health, 2012, Oregon State University
URL: http://hdl.handle.net/1957/35783
► West Nile Virus (WNV), a vector-borne disease continues to be a serious threat to public health in the United States, particularly in the Southwest region.…
(more)
▼ West Nile Virus (WNV), a vector-borne disease continues to be a serious threat to public health in the United States, particularly in the Southwest region. While all the states in the U.S. experienced a decreasing trend of WNV disease in 2010, the state of Arizona experienced a sharp increase from 20 in 2009 to 166 cases the following year. This dissertation endeavored to develop forecasting models to predict future cases of disease and identify counties with increased propensity for WNV. Furthermore, this study aimed to identify environmental and economic factors that contributed to the increase in WNV cases in Maricopa County, Arizona.
A spatiotemporal stochastic regression model was developed using Bayesian principles and was successful in calculating the annual mean cases of disease from 2003 to 2011 for all counties. The model was also able to predict future cases of disease by fitting historical data. The model-based inference identified counties in the southern region of Arizona as having an elevated propensity for disease compared to counties in the northern region.
A Seasonal Autoregressive Integrated Moving Average (SARIMA) model was developed and effectively forecasted monthly cases of human WNV in Maricopa County, Arizona. By fitting the SARIMA model to monthly historical disease data from 2005 to 2011, the temporal model presented a decreasing trend of monthly incidence of disease for 2012.
The impact of home foreclosures, climate variability, and population growth on the resurgence of human WNV disease cases in Maricopa County during the 2010 epidemic was investigated. These factors were found to have contributed to the resurgence of the disease by creating the optimal environmental conditions that allowed the amplification of mosquito populations, thus increasing the risk of disease transmission to humans.
As spatiotemporal disease data become readily available, forecasting models can be an important and viable risk assessment tool for public health practitioners. Forecasting models allow the mobilization and distribution of limited resources to areas with elevated propensity for disease, and the timely deployment of intervention programs to reduce the overall risk of disease.
Advisors/Committee Members: Veltri, Anthony T. (advisor), Stone, David L. (committee member).
Subjects/Keywords: West Nile virus – Arizona
…Prevalence and Distribution of Human West Nile Virus
Disease in the U.S
6
2.2
Clinical… …Description of Human West Nile Virus Disease
12
2.3
The Resurgence of West Nile Virus in Arizona… …15
2.4
Best Practices in the Prevention of Human West
Nile Virus Disease
20
2.1
2.5… …Forecasting Models: A Critical Risk Assessment Tool
for the Prevention of Human West Nile Virus… …schematic of West Nile Virus transmission cycle
8
2.2
The Cu lex species or common household…
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Roldan, J. J. (2012). West Nile virus : forecasting models for a resurging vector-borne disease in Arizona, U.S.A. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/35783
Chicago Manual of Style (16th Edition):
Roldan, Josiah Javier. “West Nile virus : forecasting models for a resurging vector-borne disease in Arizona, U.S.A.” 2012. Doctoral Dissertation, Oregon State University. Accessed January 17, 2021.
http://hdl.handle.net/1957/35783.
MLA Handbook (7th Edition):
Roldan, Josiah Javier. “West Nile virus : forecasting models for a resurging vector-borne disease in Arizona, U.S.A.” 2012. Web. 17 Jan 2021.
Vancouver:
Roldan JJ. West Nile virus : forecasting models for a resurging vector-borne disease in Arizona, U.S.A. [Internet] [Doctoral dissertation]. Oregon State University; 2012. [cited 2021 Jan 17].
Available from: http://hdl.handle.net/1957/35783.
Council of Science Editors:
Roldan JJ. West Nile virus : forecasting models for a resurging vector-borne disease in Arizona, U.S.A. [Doctoral Dissertation]. Oregon State University; 2012. Available from: http://hdl.handle.net/1957/35783
Erasmus University Rotterdam
28.
S.M. Lim (Stephanie).
West Nile virus in Europe : Host susceptibility, pathogenesis, and intervention studies.
Degree: 2016, Erasmus University Rotterdam
URL: http://hdl.handle.net/1765/93234
Subjects/Keywords: West Nile Virus (WNV)
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
(Stephanie), S. L. (2016). West Nile virus in Europe : Host susceptibility, pathogenesis, and intervention studies. (Thesis). Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/93234
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
(Stephanie), S.M. Lim. “West Nile virus in Europe : Host susceptibility, pathogenesis, and intervention studies.” 2016. Thesis, Erasmus University Rotterdam. Accessed January 17, 2021.
http://hdl.handle.net/1765/93234.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
(Stephanie), S.M. Lim. “West Nile virus in Europe : Host susceptibility, pathogenesis, and intervention studies.” 2016. Web. 17 Jan 2021.
Vancouver:
(Stephanie) SL. West Nile virus in Europe : Host susceptibility, pathogenesis, and intervention studies. [Internet] [Thesis]. Erasmus University Rotterdam; 2016. [cited 2021 Jan 17].
Available from: http://hdl.handle.net/1765/93234.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
(Stephanie) SL. West Nile virus in Europe : Host susceptibility, pathogenesis, and intervention studies. [Thesis]. Erasmus University Rotterdam; 2016. Available from: http://hdl.handle.net/1765/93234
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Ottawa
29.
Mallya, Shruti.
Modelling Human Risk of West Nile Virus Using Surveillance and Environmental Data
.
Degree: 2017, University of Ottawa
URL: http://hdl.handle.net/10393/35734
► Limited research has been performed in Ontario to ascertain risk factors for West Nile Virus (WNV) and to develop a unified risk prediction strategy. The…
(more)
▼ Limited research has been performed in Ontario to ascertain risk factors for West Nile Virus (WNV) and to develop a unified risk prediction strategy. The aim of the current body of work was to use spatio-temporal modelling in conjunction with surveillance and environmental data to determine which pre-WNV season factors could forecast a high risk season and to explore how well mosquito surveillance data could predict human cases in space and time during the WNV season. Generalized linear mixed modelling found that mean minimum monthly temperature variables and annual WNV-positive mosquito pools were most significantly predictive of number of human WNV cases (p<0.001). Spatio-temporal cluster analysis found that positive mosquito pool clusters could predict human case clusters up to one month in advance. These results demonstrate the usefulness of mosquito surveillance data as well as publicly available climate data for assessing risk and informing public health practice.
Subjects/Keywords: West Nile Virus;
Spatial Analysis;
Generalized Linear Mixed Modelling;
Public Health
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Mallya, S. (2017). Modelling Human Risk of West Nile Virus Using Surveillance and Environmental Data
. (Thesis). University of Ottawa. Retrieved from http://hdl.handle.net/10393/35734
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Mallya, Shruti. “Modelling Human Risk of West Nile Virus Using Surveillance and Environmental Data
.” 2017. Thesis, University of Ottawa. Accessed January 17, 2021.
http://hdl.handle.net/10393/35734.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Mallya, Shruti. “Modelling Human Risk of West Nile Virus Using Surveillance and Environmental Data
.” 2017. Web. 17 Jan 2021.
Vancouver:
Mallya S. Modelling Human Risk of West Nile Virus Using Surveillance and Environmental Data
. [Internet] [Thesis]. University of Ottawa; 2017. [cited 2021 Jan 17].
Available from: http://hdl.handle.net/10393/35734.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Mallya S. Modelling Human Risk of West Nile Virus Using Surveillance and Environmental Data
. [Thesis]. University of Ottawa; 2017. Available from: http://hdl.handle.net/10393/35734
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Texas Medical Branch – Galveston
30.
[No author].
West Nile Virus Vaccination: Current Threats and Future Considerations
.
Degree: University of Texas Medical Branch – Galveston
URL: http://hdl.handle.net/2152.3/779
The potential role of vaccination of West Nile virus in the future and the public health logistics that may be involved.
Advisors/Committee Members: de Boer, Melanie A (advisor), Freeman, Daniel H (committeeMember), Barrett, Alan D (committeeMember).Subjects/Keywords: west nile virus; vaccination
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
author], [. (n.d.). West Nile Virus Vaccination: Current Threats and Future Considerations
. (Thesis). University of Texas Medical Branch – Galveston. Retrieved from http://hdl.handle.net/2152.3/779
Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
author], [No. “West Nile Virus Vaccination: Current Threats and Future Considerations
.” Thesis, University of Texas Medical Branch – Galveston. Accessed January 17, 2021.
http://hdl.handle.net/2152.3/779.
Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
author], [No. “West Nile Virus Vaccination: Current Threats and Future Considerations
.” Web. 17 Jan 2021.
Note: this citation may be lacking information needed for this citation format:
No year of publication.
Vancouver:
author] [. West Nile Virus Vaccination: Current Threats and Future Considerations
. [Internet] [Thesis]. University of Texas Medical Branch – Galveston; [cited 2021 Jan 17].
Available from: http://hdl.handle.net/2152.3/779.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.
Council of Science Editors:
author] [. West Nile Virus Vaccination: Current Threats and Future Considerations
. [Thesis]. University of Texas Medical Branch – Galveston; Available from: http://hdl.handle.net/2152.3/779
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.
◁ [1] [2] [3] [4] [5] [6] [7] [8] ▶
. 
Open Access Theses and Dissertations
