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Georgia Tech

1. McLane, Jesica Mata. Investigation of 1alpha,25-dihydroxy vitamin D3 membrane receptor ERp60 in adipocytes from male and female lean and obese mice.

Degree: MS, Biomedical Engineering, 2009, Georgia Tech

URL: http://hdl.handle.net/1853/31793 

The purpose of this study is to determine whether or not adipocytes harvested directly from fat pads or induced from bone marrow in lean and obese mice exhibit a sex-dependent rapid response to vitamin D metabolite 1á,25(OH)2D3 and if so to elucidate if it is via an ERp60 receptor mediated signaling pathway. The role of 1á,25(OH)2D3 and specifically the membrane effect will be examined in two genetically distinct mice to see if their cells have a differing sensitivity. The results indicate that there are differing responses in adipocytes that are induced from bone marrow versus differentiated fat pad adipocytes, and the function of 1á,25(OH)2D3 is sex-specific in some cases. Additionally, all the adipocytes tested demonstrated a rapid response to 1á,25(OH)2D3; mRNA for nVDR and ERp60 were found in all cells however the only functional protein found in the plasma membrane was ERp60 indicating that it may be necessary for the rapid response whereas nVDR is not required. Advisors/Committee Members: Dr. Barbara Boyan (Committee Chair), Dr. Zvi Schwartz (Committee Co-Chair), Dr. Hanjoong Jo (Committee Member).

Subjects/Keywords: Vitamin D; Pdia3; Vitmain D receptor; ERp60; Adipocytes; PKC; Adipogenesis; Fat cells; Adipose tissues; Cell receptors

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

McLane, J. M. (2009). Investigation of 1alpha,25-dihydroxy vitamin D3 membrane receptor ERp60 in adipocytes from male and female lean and obese mice. (Masters Thesis). Georgia Tech. Retrieved from http://hdl.handle.net/1853/31793

Chicago Manual of Style (16th Edition):

McLane, Jesica Mata. “Investigation of 1alpha,25-dihydroxy vitamin D3 membrane receptor ERp60 in adipocytes from male and female lean and obese mice.” 2009. Masters Thesis, Georgia Tech. Accessed February 28, 2021. http://hdl.handle.net/1853/31793.

MLA Handbook (7th Edition):

McLane, Jesica Mata. “Investigation of 1alpha,25-dihydroxy vitamin D3 membrane receptor ERp60 in adipocytes from male and female lean and obese mice.” 2009. Web. 28 Feb 2021.

Vancouver:

McLane JM. Investigation of 1alpha,25-dihydroxy vitamin D3 membrane receptor ERp60 in adipocytes from male and female lean and obese mice. [Internet] [Masters thesis]. Georgia Tech; 2009. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1853/31793.

Council of Science Editors:

McLane JM. Investigation of 1alpha,25-dihydroxy vitamin D3 membrane receptor ERp60 in adipocytes from male and female lean and obese mice. [Masters Thesis]. Georgia Tech; 2009. Available from: http://hdl.handle.net/1853/31793

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