subject:(Vascular grafts)

University of Utah

1. Vickers, Daniel Baker. Hyperthermia for treatment of hyperplasia in a hemodialysis access graft.

Degree: MS;, Bioengineering;, 2008, University of Utah

URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1473/rec/598

► I would like to express my appreciation to my supervisory committee. Committee chair Dr. Douglas Christensen provided the knowledge and expertise to make this all… (more)

Subjects/Keywords: Vascular grafts; Hemodialysis; Stenosis; Hyperplasia

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APA (6^th Edition):

Vickers, D. B. (2008). Hyperthermia for treatment of hyperplasia in a hemodialysis access graft. (Masters Thesis). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1473/rec/598

Chicago Manual of Style (16^th Edition):

Vickers, Daniel Baker. “Hyperthermia for treatment of hyperplasia in a hemodialysis access graft.” 2008. Masters Thesis, University of Utah. Accessed July 21, 2019. http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1473/rec/598.

MLA Handbook (7^th Edition):

Vickers, Daniel Baker. “Hyperthermia for treatment of hyperplasia in a hemodialysis access graft.” 2008. Web. 21 Jul 2019.

Vancouver:

Vickers DB. Hyperthermia for treatment of hyperplasia in a hemodialysis access graft. [Internet] [Masters thesis]. University of Utah; 2008. [cited 2019 Jul 21]. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1473/rec/598.

Council of Science Editors:

Vickers DB. Hyperthermia for treatment of hyperplasia in a hemodialysis access graft. [Masters Thesis]. University of Utah; 2008. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1473/rec/598

University of Limerick

2. Coakley, Daniel Nicholas Martin. Evaluation of xenogenic extracellular matrix scaffolds for use in tissue engineered vascular grafts.

Degree: 2015, University of Limerick

URL: http://hdl.handle.net/10344/4882

► Existing synthetic vascular grafts have unacceptably high failure rates when replacing below knee arteries. In vitro endothelialisation is an emerging procedure that has been shown… (more)

▼ Existing synthetic vascular grafts have unacceptably high failure rates when replacing below knee arteries. In vitro endothelialisation is an emerging procedure that has been shown to enhance the patency rates of below knee synthetic vascular grafts. Here autologous endothelial cells are harvested and cultured on the lining of the graft prior to implantation. The technique is limited by the narrow time frame availalble for culture and the finite cells obtainable following harvest. As well as this, existing synthetic materials are poor cellular substrates and must be combined with coatings to promote cellular growth and attachment. The most common coated graft used clinically is fibrin-coated polytetrafluoroethylene (ePTFE). The study aim was to compare the endothelialisation of fibrin-coated ePTFE with emerging novel extracellular matrix (ECM) scaffolds, which we hypothesise will provide a superior substrate for cell growth by mimicking the in vivo environment more closely. We also construct and verify a novel subatmospheric bioreactor in order to enhance the proliferation of cultured cells. Finally, we examine the culturing of endothelial cells inside the lumen of small diameter ECM vascular grafts. Our Results showed that cells remained viable and produced von Willebrand factor on all substrates tested. There was no difference in adhesion rates between ECM scaffolds and fibrin-coated ePTFE (p = 1.00). Endothelial cells proliferated fastest on ECM scaffolds when compared to all other materials tested (p <0.001). When seeded scaffolds were exposed to subatmospheric pressures in a closed bioreactor a mechanical strain was exerted on the construct. This was shown to alter cellular morphology and enhance cellular proliferation. We found we could rapidly form a confluent endothelial lining on the luminal surface of small diameter ECM grafts. In conclusion, ECM bioscaffolds offer a superior substrate for promoting rapid endothelialisation compared to existing fibrin-coated ePTFE by combining firm cellular anchorage and rapid cell expansion. Proliferation rates were positively influenced by a subatmospheric bioreactor. This work suggests that ECM materials are promising scaffolds for use in small vessel tissue engineering. Advisors/Committee Members: Robinson, J.S., Lavin, Michael.

Subjects/Keywords: synthetic vascular grafts; cardiovascular system

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APA (6^th Edition):

Coakley, D. N. M. (2015). Evaluation of xenogenic extracellular matrix scaffolds for use in tissue engineered vascular grafts. (Thesis). University of Limerick. Retrieved from http://hdl.handle.net/10344/4882

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Coakley, Daniel Nicholas Martin. “Evaluation of xenogenic extracellular matrix scaffolds for use in tissue engineered vascular grafts.” 2015. Thesis, University of Limerick. Accessed July 21, 2019. http://hdl.handle.net/10344/4882.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Coakley, Daniel Nicholas Martin. “Evaluation of xenogenic extracellular matrix scaffolds for use in tissue engineered vascular grafts.” 2015. Web. 21 Jul 2019.

Vancouver:

Coakley DNM. Evaluation of xenogenic extracellular matrix scaffolds for use in tissue engineered vascular grafts. [Internet] [Thesis]. University of Limerick; 2015. [cited 2019 Jul 21]. Available from: http://hdl.handle.net/10344/4882.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Coakley DNM. Evaluation of xenogenic extracellular matrix scaffolds for use in tissue engineered vascular grafts. [Thesis]. University of Limerick; 2015. Available from: http://hdl.handle.net/10344/4882

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Limerick

3. Davis, Laura M. Towards the development of a physiologically mimetic tissue engineered cardiovascular graft for the treatment of abdominal aortic aneurysms.

Degree: 2014, University of Limerick

URL: http://hdl.handle.net/10344/4208

►

peer-reviewed

With cardiovascular pathologies continuing to prevail, effective arterial replacements for the minimally invasive treatment of abdominal aortic aneurysms (AAAs) through endovascular aneurysm repair (EVAR)… (more)

▼

peer-reviewed

With cardiovascular pathologies continuing to prevail, effective arterial replacements for the minimally invasive treatment of abdominal aortic aneurysms (AAAs) through endovascular aneurysm repair (EVAR) are still an under-developed approach. A proposed solution to the identified problems of EVAR, including stent-graft migration and endoleaks, focuses on the use of a tissue engineered (TE) collar to create a biological seal between the device and the host artery. TE acellular vascular grafts are an emerging concept with the development and optimisation of biological scaffolds composed of naturally derived ECM, such as small intestinal submucosa (SIS) and urinary bladder matrix (UBM), receiving significant attention in the field of TE. In this research material characteristics such as scaffold surface topography and material wettability, of both naturally derived ECMs and comparative synthetically engineered materials were evaluated. As efficient endothelialisation is a desirable characteristic, cellular adhesion and proliferation as well as the interaction between the scaffold material and vascular cells were examined together with an assessment of scaffold mechanical behaviour. Overall, naturally derived ECM scaffolds demonstrated superior biocompatible surfaces for cellular growth, adhesion and proliferation while also exhibiting the biomechanical properties necessary to withstand the in vivo environment and providing improved compliance than currently employed synthetic materials. A factor currently limiting the success of biological scaffolds is effective shelf stable storage. This research demonstrated the viability, mechanical integrity and bioactive potential of ECM stent-grafts as suitable off-the-shelf vascular prosthetic devices. The effect of long-term hydrated storage in stented and un-stented configurations on the mechanical performance and bioactive potential of SIS and UBM were analysed. Additionally, inflammatory inducing cellular remnants leached after hydrated storage of single and multi-ply ECM scaffolds were quantified and the effect of such leached products on cellular proliferation was investigated. Residual DNA present in the scaffold after the hydration period was also evaluated. Results from these studies indicated a globally beneficial effect of hydrated storage on ECM material performance at both a biomechanical and biological level with hydration also facilitating the removal of residual cellular remnants from the ECM scaffolds prior to implantation. Due to the inherent similarities of ECM composition and the intended vascular site of implantation, the potential of decellularised porcine aortic tissue to develop a novel acellular TE collar material was investigated. Material decellularisation was examined with extensive evaluation of mechanical properties and residual cellular remnants. The resulting decellularised scaffolds demonstrated successful cellular adhesion indicating the potential of the material as a vascular graft upon…

Advisors/Committee Members: Walsh, Michael T., Carroll, Gráinne, McGloughlin, Timothy M., EI, European Regional Development Fund.

Subjects/Keywords: abdominal aortic aneurysms; ECMs; vascular grafts

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APA (6^th Edition):

Davis, L. M. (2014). Towards the development of a physiologically mimetic tissue engineered cardiovascular graft for the treatment of abdominal aortic aneurysms. (Thesis). University of Limerick. Retrieved from http://hdl.handle.net/10344/4208

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Davis, Laura M. “Towards the development of a physiologically mimetic tissue engineered cardiovascular graft for the treatment of abdominal aortic aneurysms.” 2014. Thesis, University of Limerick. Accessed July 21, 2019. http://hdl.handle.net/10344/4208.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Davis, Laura M. “Towards the development of a physiologically mimetic tissue engineered cardiovascular graft for the treatment of abdominal aortic aneurysms.” 2014. Web. 21 Jul 2019.

Vancouver:

Davis LM. Towards the development of a physiologically mimetic tissue engineered cardiovascular graft for the treatment of abdominal aortic aneurysms. [Internet] [Thesis]. University of Limerick; 2014. [cited 2019 Jul 21]. Available from: http://hdl.handle.net/10344/4208.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Davis LM. Towards the development of a physiologically mimetic tissue engineered cardiovascular graft for the treatment of abdominal aortic aneurysms. [Thesis]. University of Limerick; 2014. Available from: http://hdl.handle.net/10344/4208

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of California – Berkeley

4. Huang, Fang. Engineering Biomaterials and Biomolecules for Vascular Regeneration.

Degree: Bioengineering, 2016, University of California – Berkeley

URL: http://www.escholarship.org/uc/item/47m0z167

► Tissue engineering and regenerative medicine is a multidisciplinary field that combines the knowledge and technologies of biology, materials, chemistry and medicine among others. Within the… (more)

▼ Tissue engineering and regenerative medicine is a multidisciplinary field that combines the knowledge and technologies of biology, materials, chemistry and medicine among others. Within the realm of tissue repair and regeneration, vascular reconstruction, in particular, is influenced by both biophysical and biochemical cues and it is critical to fully understand how these cues interact with the physiological microenvironment. In this dissertation, we demonstrated how host vascular regenerative potential can be harnessed by optimizing vascular grafts from both the biomaterial and biochemical perspectives. We utilized and optimized electrospinning technology to create microfibrous vascular grafts. We showed that incorporating a fast degrading polymer into the vascular grafts effectively enhances cell infiltration without majorly compromising its mechanical and structural properties. Our in vivo data suggests that although the optimized vascular graft was able to induce the initiation of vascular regeneration, the process was accelerated and enhanced with the help of biochemical cues presented in the form of stromal cell-derived factor-1α (SDF-1α). In the presence of chemokine SDF-1α, the vascular grafts demonstrated better wall remodeling and long-term patency. This observation again highlights the significance of both biomaterial and biochemical effects. While the vascular grafts in our studies might recruit inflammatory cells, calcification which is a destructive complication typically associated with inflammatory response was not observed. The final part of this dissertation details our efforts in using protein engineering to broaden the biological application of SDF-1α by introducing a free cysteine residue on its C-terminus. We showed that the cysteine-modified SDF-1α exhibits a bioactivity different from its unmodified counterpart, the underlying mechanism of which needs to be elucidated in future studies. Taken together, this work is expected to provide insights into optimization of vascular graft platforms for broad therapeutic applications.

Subjects/Keywords: Biomedical engineering; Biomaterials; Electrospinning; SDF-1α; Tissue Engineering; Vascular Grafts; Vascular Regeneration

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APA (6^th Edition):

Huang, F. (2016). Engineering Biomaterials and Biomolecules for Vascular Regeneration. (Thesis). University of California – Berkeley. Retrieved from http://www.escholarship.org/uc/item/47m0z167

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Huang, Fang. “Engineering Biomaterials and Biomolecules for Vascular Regeneration.” 2016. Thesis, University of California – Berkeley. Accessed July 21, 2019. http://www.escholarship.org/uc/item/47m0z167.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Huang, Fang. “Engineering Biomaterials and Biomolecules for Vascular Regeneration.” 2016. Web. 21 Jul 2019.

Vancouver:

Huang F. Engineering Biomaterials and Biomolecules for Vascular Regeneration. [Internet] [Thesis]. University of California – Berkeley; 2016. [cited 2019 Jul 21]. Available from: http://www.escholarship.org/uc/item/47m0z167.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Huang F. Engineering Biomaterials and Biomolecules for Vascular Regeneration. [Thesis]. University of California – Berkeley; 2016. Available from: http://www.escholarship.org/uc/item/47m0z167

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas A&M University

5. Bulick, Allen. Systematic Investigation of Hydrogel Material Properties on Cell Responses for Vocal Fold and Vascular Graft Tissue Engineering.

Degree: 2010, Texas A&M University

URL: http://hdl.handle.net/1969.1/ETD-TAMU-2009-08-3249

► The research presented here deals with synthetic materials for application in tissue engineering, primarily poly(ethylene glycol) (PEG) and poly(dimethyl siloxane)star (PDMS)star. Tissue engineering seeks to… (more)

▼ The research presented here deals with synthetic materials for application in tissue engineering, primarily poly(ethylene glycol) (PEG) and poly(dimethyl siloxane)star (PDMS)star. Tissue engineering seeks to repair or replace damaged tissue through implantation of cell encapsulated in an artificial scaffold. Cell differentiation and extracellular matrix (ECM) deposition can be influenced through a wide variety of in vitro culture techniques including biochemical stimuli, cell-cell interactions, mechanical conditioning and scaffold physical properties. In order to systematically optimize in vitro conditions for tissue engineering experiments, the individual effects of these different components must be studied. PEG hydrogels are a suitable scaffold for this because of their biocompatibility and biological "blank slate" nature. This dissertation presents data investigating: the effects of glycosaminoglycans (GAGs) as biochemical stimuli on pig vocal fold fibroblasts (PVFfs); the effects of mechanical conditioning and cell-cell interactions on smooth muscle cells (SMCs); and the effects of scaffold physical properties on SMCs. Results show that GAGs influence PVFf behavior and are an important component in scaffold design. Hyaluronic acid (HA) formulations showed similar production in collagen I and III as well as reduced levels of smooth muscle a-actin (SMa-actin), while chondroitin sulfate (CSC) and heparin sulfate showed enriched collagen III environments with enhanced expression of SMa-actin. A physiological flow system was developed to give comprehensive control over in vitro mechanical conditioning on TEVGs. Experiments performed on SMCs involved creating multi-layered TEVGs to mimic natural vascular tissue. Constructs subjected to mechanical conditioning with an endothelial cell (EC) layer showed enhanced expression of SMC differentiation markers calponin h1 and myocardin and enhanced deposition of elastin. Consistent with other studies, EC presence diminished overall collagen production and collagen I, specifically. Novel PDMSstar-PEG hydrogels were studied to investigate the effects of inorganic content on mesenchymal stem cell differentiation for use in TEVGs. Results agree with previous observations showing that a ratio of 5:95 PDMSstar: PEG by weight enhances SMC differentiation markers; however, statistically significant conclusions could not be made. By studying and optimizing in vitro culture conditions including scaffold properties, mechanical conditioning and multi-layered cell-cell interactions, TEVGs can be designed to maximize SMC differentiation and ECM production. Advisors/Committee Members: Hahn, Mariah (advisor), Pishko, Michael (committee member), Grunlan, Melissa (committee member), Cheng, Zhengdong (committee member).

Subjects/Keywords: Tissue Engineering; Smooth Muscle Cells; Vocal Fold; Vascular Grafts

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APA (6^th Edition):

Bulick, A. (2010). Systematic Investigation of Hydrogel Material Properties on Cell Responses for Vocal Fold and Vascular Graft Tissue Engineering. (Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/ETD-TAMU-2009-08-3249

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bulick, Allen. “Systematic Investigation of Hydrogel Material Properties on Cell Responses for Vocal Fold and Vascular Graft Tissue Engineering.” 2010. Thesis, Texas A&M University. Accessed July 21, 2019. http://hdl.handle.net/1969.1/ETD-TAMU-2009-08-3249.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bulick, Allen. “Systematic Investigation of Hydrogel Material Properties on Cell Responses for Vocal Fold and Vascular Graft Tissue Engineering.” 2010. Web. 21 Jul 2019.

Vancouver:

Bulick A. Systematic Investigation of Hydrogel Material Properties on Cell Responses for Vocal Fold and Vascular Graft Tissue Engineering. [Internet] [Thesis]. Texas A&M University; 2010. [cited 2019 Jul 21]. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2009-08-3249.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bulick A. Systematic Investigation of Hydrogel Material Properties on Cell Responses for Vocal Fold and Vascular Graft Tissue Engineering. [Thesis]. Texas A&M University; 2010. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2009-08-3249

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Georgia Tech

6. Greer, Linda S. Material property testing of a collagen/smooth muscle cell gel for the development of a tissue engineered vascular graft.

Degree: MS, Mechanical engineering, 1994, Georgia Tech

URL: http://hdl.handle.net/1853/33447

Subjects/Keywords: Tissues; Biomedical engineering; Vascular grafts

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APA (6^th Edition):

Greer, L. S. (1994). Material property testing of a collagen/smooth muscle cell gel for the development of a tissue engineered vascular graft. (Masters Thesis). Georgia Tech. Retrieved from http://hdl.handle.net/1853/33447

Chicago Manual of Style (16^th Edition):

Greer, Linda S. “Material property testing of a collagen/smooth muscle cell gel for the development of a tissue engineered vascular graft.” 1994. Masters Thesis, Georgia Tech. Accessed July 21, 2019. http://hdl.handle.net/1853/33447.

MLA Handbook (7^th Edition):

Greer, Linda S. “Material property testing of a collagen/smooth muscle cell gel for the development of a tissue engineered vascular graft.” 1994. Web. 21 Jul 2019.

Vancouver:

Greer LS. Material property testing of a collagen/smooth muscle cell gel for the development of a tissue engineered vascular graft. [Internet] [Masters thesis]. Georgia Tech; 1994. [cited 2019 Jul 21]. Available from: http://hdl.handle.net/1853/33447.

Council of Science Editors:

Greer LS. Material property testing of a collagen/smooth muscle cell gel for the development of a tissue engineered vascular graft. [Masters Thesis]. Georgia Tech; 1994. Available from: http://hdl.handle.net/1853/33447

Clemson University

7. Khanna, Astha. Fabrication of Human Serum Albumin Film for Enhanced Hemocompatibility and Mitigation of Intimal Hyperplasia Under Physiologically Relevant Flow Shear Conditions.

Degree: PhD, Bioengineering, 2017, Clemson University

URL: https://tigerprints.clemson.edu/all_dissertations/2060

► Current endovascular stents and synthetic vascular grafts have poor clinical outcomes in small diameter applications due to high incidence of thrombogenicity and intimal hyperplasia. To… (more)

▼ Current endovascular stents and synthetic vascular grafts have poor clinical outcomes in small diameter applications due to high incidence of thrombogenicity and intimal hyperplasia. To address this, we have developed an albumin film for mitigation of the complications of platelet adhesion and smooth muscle cell hyperplasia and hypertrophy. A human serum albumin (HSA) film is fabricated on an anchoring layer of poly (glycidyl methacrylate) on surfaces of metallic and polymeric substrates. The PGMA and HSA layers are characterized by FT-IR spectroscopy, scanning electron microscopy, energy dispersive X-ray spectroscopy and contact angle analysis. We have confirmed the thromboresistance of albumin film by in vitro measurement of adsorption of human fibrinogen and platelets. We found that albumin film controlled the adsorption of fibrinogen evidenced by measurement of fluorescently labeled protein and adhesion force measurement. Human platelet adhesion was significantly lower on albumin coated compared to uncoated substrates. Smooth muscle cells play a key role in progression of intimal hyperplasia and hence we assessed the proliferation, hypertrophy and contractile state of cells in static and flow conditions. A vascular simulator was employed to provide forces of cyclic strain and flow shear to smooth muscle cells on albumin coated and uncoated ePTFE grafts. It was found that albumin film controlled proliferation and maintained the contractile state of smooth muscle cells on nitinol and ePTFE substrates. We developed a flow circulation loop model to assess the response of fibrinogen and platelets on albumin coated and uncoated e PTFE grafts. A significantly lower adsorption of fibrinogen and platelet adhesion was measured on albumin coated e PTFE grafts compared to uncoated grafts. Exhibiting strong adhesion strength to polymeric and metallic substrates, human albumin film fabricated using PGMA as an anchoring layer has been shown to shield the surface from adhesive protein fibrinogen and prevents adhesion of platelets thereby providing an anti-thrombogenic layer. Human albumin has been shown to maintain a controlled proliferation profile and spindle shaped morphology of vascular smooth muscle cells with increased expression of contractile protein smooth muscle alpha actin mitigating the complication of intimal hyperplasia post a percutaneous interventional procedure and bypass surgery. Advisors/Committee Members: Martine LaBerge, Ph.D., Committee Chair, Igor Luzinov, Ph.D., Agneta Simionescu, Ph.D., Vladimir Reukov, Ph.D., Eugene M. Langan III, M.D..

Subjects/Keywords: Bypass grafts; Endovascular stents; Hemocompatibility; Medical Devices; Vascular Devices

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APA (6^th Edition):

Khanna, A. (2017). Fabrication of Human Serum Albumin Film for Enhanced Hemocompatibility and Mitigation of Intimal Hyperplasia Under Physiologically Relevant Flow Shear Conditions. (Doctoral Dissertation). Clemson University. Retrieved from https://tigerprints.clemson.edu/all_dissertations/2060

Chicago Manual of Style (16^th Edition):

Khanna, Astha. “Fabrication of Human Serum Albumin Film for Enhanced Hemocompatibility and Mitigation of Intimal Hyperplasia Under Physiologically Relevant Flow Shear Conditions.” 2017. Doctoral Dissertation, Clemson University. Accessed July 21, 2019. https://tigerprints.clemson.edu/all_dissertations/2060.

MLA Handbook (7^th Edition):

Khanna, Astha. “Fabrication of Human Serum Albumin Film for Enhanced Hemocompatibility and Mitigation of Intimal Hyperplasia Under Physiologically Relevant Flow Shear Conditions.” 2017. Web. 21 Jul 2019.

Vancouver:

Khanna A. Fabrication of Human Serum Albumin Film for Enhanced Hemocompatibility and Mitigation of Intimal Hyperplasia Under Physiologically Relevant Flow Shear Conditions. [Internet] [Doctoral dissertation]. Clemson University; 2017. [cited 2019 Jul 21]. Available from: https://tigerprints.clemson.edu/all_dissertations/2060.

Council of Science Editors:

Khanna A. Fabrication of Human Serum Albumin Film for Enhanced Hemocompatibility and Mitigation of Intimal Hyperplasia Under Physiologically Relevant Flow Shear Conditions. [Doctoral Dissertation]. Clemson University; 2017. Available from: https://tigerprints.clemson.edu/all_dissertations/2060

Drexel University

8. Ostroha, Jamie Lyn. Peptide-modified polymer for endothelialization.

Degree: 2001, Drexel University

URL: http://hdl.handle.net/1860/73

►

A functionalized polycarbonate material derived from tyrosine containing varyinglevels of free acid functionality along the backbone, poly(DTE-co-X%DT carbonate), hasbeen functionalized with a peptide to promote… (more)

▼

A functionalized polycarbonate material derived from tyrosine containing varyinglevels of free acid functionality along the backbone, poly(DTE-co-X%DT carbonate), hasbeen functionalized with a peptide to promote endothelial cell attachment and evaluatedas a potential synthetic vascular graft material. Lysine derivatives have been produced topromote the attachment of engineered peptides for promoting endothelialization.NMR has been used to analyze the initial structure of the poly(DTEC-co-X%DTC) and changes in the structure with the attachment of L-lysine ethyl ester andpolylysine, polyalanine, and the (ARKKAAKA)4 peptide. The polymer peak at 4.8 ppmhas been labeled the a-peak. This peak is the primary peak used to evaluate changes inthe spectra related to changing polymer functionality and the attachment of molecules tothe pendant acid group. Changes in the Ã-peak (3.05 ppm), the R2 peak (4.1 ppm) and theR3 peak (1.3 ppm) are compared to the a-peak for quantification purposes. Key NMRpeaks have been identified and lysine attachment and quantification is discussed. A lysinepeak has been identified at 4.38 ppm. This peak is also compared to the polymer a-peak,indicating 85-90% attachment efficiency. The use of polylysine, polyalanine, andpeptides establish that peptide binding is successful; qualitative and semi-quantitativeresults are presented. Semi-quantitative results with polyalanine indicate a large degree ofattachment, although some interference with the spectral peaks has been noted.The effect of poly(DTEC-co-X%DTC) on human endothelial cell attachment andgrowth is also studied and compared to current synthetic materials. Cell attachment hasbeen shown to increase significantly as the polymer becomes more hydrophilic. Nonfunctionalizedpolymers show that less than five percent of cells remained attach at aforce of 300 g, while 50% functionalized polymers show 40% attachment at the sameforce. Cell growth studies show an increase in cell affinity with increasing hydophilicity.35% functionalized polymer shows over double the number of cells as the nonfunctionalizedmaterial after seven days. The results for the p(DTEC) at increasing levelsof functionality bracket Dacron and PLA depending. Cell spreading, confluence, anddivision have been confirmed by visual analysis.

M.S., Materials Engineering – Drexel University, 2001

Advisors/Committee Members: Twardowski, Thomas.

Subjects/Keywords: Vascular grafts; Polymers in medicine

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APA (6^th Edition):

Ostroha, J. L. (2001). Peptide-modified polymer for endothelialization. (Thesis). Drexel University. Retrieved from http://hdl.handle.net/1860/73

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ostroha, Jamie Lyn. “Peptide-modified polymer for endothelialization.” 2001. Thesis, Drexel University. Accessed July 21, 2019. http://hdl.handle.net/1860/73.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ostroha, Jamie Lyn. “Peptide-modified polymer for endothelialization.” 2001. Web. 21 Jul 2019.

Vancouver:

Ostroha JL. Peptide-modified polymer for endothelialization. [Internet] [Thesis]. Drexel University; 2001. [cited 2019 Jul 21]. Available from: http://hdl.handle.net/1860/73.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ostroha JL. Peptide-modified polymer for endothelialization. [Thesis]. Drexel University; 2001. Available from: http://hdl.handle.net/1860/73

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Virginia Tech

9. Gurjarpadhye, Abhijit Achyut. Dynamic Non-Destructive Monitoring of Bioengineered Blood Vessel Development within a Bioreactor using Multi-Modality Imaging.

Degree: PhD, Biomedical Engineering, 2013, Virginia Tech

URL: http://hdl.handle.net/10919/51359

► Regenerative medicine involves formation of tissue or organ for replacement of a wounded or dysfunctional tissue. Healthy cells extracted from the patient are expanded and… (more)

▼ Regenerative medicine involves formation of tissue or organ for replacement of a wounded or dysfunctional tissue. Healthy cells extracted from the patient are expanded and are seeded on a three-dimensional biodegradable scaffold. The structure is then placed in a bioreactor and is provided with nutrients for the cells, which proliferate and migrate throughout the scaffold to eventually form a desired to tissue that can be transplanted into the patient\'s body. Inability to monitor this complex process of regeneration in real-time makes control and optimization of this process extremely difficult. Histology, the gold standard used for tissue structural assessment, is a static technique that only provides "snapshots" of the progress and requires the specimen to be sacrificed. This inefficiency severely limits our understanding of the biological processes associated with tissue growth during the in vitro pre-conditioning phase. Optical Coherence Tomography (OCT) enables imaging of cross sectional structure in biological tissues by measuring the echo time delay of backreflected light. OCT has recently emerged as an important method to assess the structures of physiological, pathological as well as tissue engineered blood vessels. The goal of the present study is to develop an imaging system for non-destructive monitoring of blood vessels maturing within a bioreactor. Non-destructive structural imaging of tissue-engineered blood vessels cultured in a novel bioreactor was performed using free-space and catheter-based OCT imaging, while monitoring of the endothelium development was performed using a fluorescence imaging system that utilizes a commercial OCT catheter. The project included execution of three specific aims. Firstly, we developed OCT instrumentation to determine geometrical and optical properties of porcine and human skin in real-time. The purpose of the second aim was to assess structural development of tissue-engineered blood vessels maturing in a bioreactor. We constructed a novel quartz-based bioreactor that will permit free space and catheter-based OCT imaging of vascular grafts. The grafts were made of biodegradable PCL-collagen and seeded with multipotent mesenchymal cells. We imaged the maturing grafts over 30 days to assess changes in graft wall thickness. We also monitored change in optical properties of the grafts based on free-space OCT scanning. Finally, in order to visualize the proliferation of endothelial cells and development of the endothelium, we developed an imaging system that utilizes a commercial OCT catheter for single-cell-level imaging of the growing endothelium of a tissue-engineered blood vessel. We have developed two modules of an imaging system for non-destructive monitoring of maturing bioengineered vascular grafts. The first module provides the ability to non-destructively examine the structure of the grafts while the second module can track the progress of endothelialization. As both modules use the same endoscope for imaging, when operated in… Advisors/Committee Members: Rylander, Christopher G. (committeechair), Rylander, M Nichole (committee member), Wang, Ge (committee member), Soker, Shay (committee member), Xu, Yong (committee member).

Subjects/Keywords: Optical Coherence Tomography; Fluorescence Imaging; Vascular Grafts; Bioreactor; Non-destructive

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gurjarpadhye, A. A. (2013). Dynamic Non-Destructive Monitoring of Bioengineered Blood Vessel Development within a Bioreactor using Multi-Modality Imaging. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/51359

Chicago Manual of Style (16^th Edition):

Gurjarpadhye, Abhijit Achyut. “Dynamic Non-Destructive Monitoring of Bioengineered Blood Vessel Development within a Bioreactor using Multi-Modality Imaging.” 2013. Doctoral Dissertation, Virginia Tech. Accessed July 21, 2019. http://hdl.handle.net/10919/51359.

MLA Handbook (7^th Edition):

Gurjarpadhye, Abhijit Achyut. “Dynamic Non-Destructive Monitoring of Bioengineered Blood Vessel Development within a Bioreactor using Multi-Modality Imaging.” 2013. Web. 21 Jul 2019.

Vancouver:

Gurjarpadhye AA. Dynamic Non-Destructive Monitoring of Bioengineered Blood Vessel Development within a Bioreactor using Multi-Modality Imaging. [Internet] [Doctoral dissertation]. Virginia Tech; 2013. [cited 2019 Jul 21]. Available from: http://hdl.handle.net/10919/51359.

Council of Science Editors:

Gurjarpadhye AA. Dynamic Non-Destructive Monitoring of Bioengineered Blood Vessel Development within a Bioreactor using Multi-Modality Imaging. [Doctoral Dissertation]. Virginia Tech; 2013. Available from: http://hdl.handle.net/10919/51359

Virginia Commonwealth University

10. Wolfe, Patricia. Tissue Engineering an Acellular Bioresorbable Vascular Graft to Promote Regeneration.

Degree: PhD, Biomedical Engineering, 2011, Virginia Commonwealth University

URL: https://scholarscompass.vcu.edu/etd/2627

► Tissue engineering is an interdisciplinary field that aims to restore, maintain, or improve diseased or damaged tissues. Electrospinning has become one of the most popular… (more)

▼ Tissue engineering is an interdisciplinary field that aims to restore, maintain, or improve diseased or damaged tissues. Electrospinning has become one of the most popular means to fabricate a scaffold for various tissue engineering applications as the process is extremely versatile and inexpensive. The ability for electrospinning to consistently create nanofibrous structures capable of mimicking the native extracellular matrix (ECM) is the basis behind why this technique is so successful in tissue engineering. Cardiovascular disease has been the leading cause of death in the United States for over 100 years, and because of this, the need for coronary artery replacements is in serious demand. More specifically, small diameter vessels (<6 mm I.D.) are most needed, due to the fact that they are most often affected and the current clinical replacements provide less than optimal long-term patency and regenerative ability. Tissue engineering of vascular grafts has been investigated for over 50 years, however, synthetic replacements made of Dacron® and expanded-poly(tetrafluoroethylene) (e-PTFE) still remain the clinical standard. This study examines a variety of different ways to alter different characteristics of electrospun constructs, to create scaffolds that would be favorable for use as a blood vessel replacement; the end goal being the creation of an acellular bioresorbable vascular graft that would provide sufficient mechanical support to withstand physiological forces, as well as ample biocompatibility to allow host cells to infiltrate and regenerate the graft as the structure degrades. As a way of tailoring the mechanical and thermal properties of a scaffold to be more conducive to that of a native artery, a novel co-polymer was created from the random copolymerization of two monomers; 1,4-Dioxan-2-one (DX) and DL-3-methyl-1,4-dioxan-2-one (DL-3-MeDX) were mixed at different ratios and electrospun, forming nanofibrous scaffolds that exhibited different mechanical and thermal properties. Next, scaffolds were electrospun from natural and synthetic polymers, and the potential for these materials to elicit the formation of an acute thrombotic occlusion was investigated by quantifying tissue factor expression from monocytes using a novel technique. Tissue factor expression by monocytes on the electrospun natural and synthetic polymer scaffolds was compared to that of e-PTFE to determine their potential for use as vascular graft materials. Platelet-rich plasma (PRP), a naturally occurring blood component which is comprised of supraphysiologic concentrations of autologous growth factors, was activated and lyophilized to form a preparation rich in growth factors (PRGF). PRGF was electrospun for the first time, to create a scaffold that would mimic the role of the native ECM in the wound healing cascade. Characterization of these scaffolds proved their bioactivity was enhanced, with cell infiltration occurring throughout the structures in as little as 3 days. Lastly, PRP/PRGF and/or heparin were incorporated into… Advisors/Committee Members: Gary Bowlin.

Subjects/Keywords: tissue engineering; electrospinning; vascular grafts; Biomedical Engineering and Bioengineering; Engineering

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wolfe, P. (2011). Tissue Engineering an Acellular Bioresorbable Vascular Graft to Promote Regeneration. (Doctoral Dissertation). Virginia Commonwealth University. Retrieved from https://scholarscompass.vcu.edu/etd/2627

Chicago Manual of Style (16^th Edition):

Wolfe, Patricia. “Tissue Engineering an Acellular Bioresorbable Vascular Graft to Promote Regeneration.” 2011. Doctoral Dissertation, Virginia Commonwealth University. Accessed July 21, 2019. https://scholarscompass.vcu.edu/etd/2627.

MLA Handbook (7^th Edition):

Wolfe, Patricia. “Tissue Engineering an Acellular Bioresorbable Vascular Graft to Promote Regeneration.” 2011. Web. 21 Jul 2019.

Vancouver:

Wolfe P. Tissue Engineering an Acellular Bioresorbable Vascular Graft to Promote Regeneration. [Internet] [Doctoral dissertation]. Virginia Commonwealth University; 2011. [cited 2019 Jul 21]. Available from: https://scholarscompass.vcu.edu/etd/2627.

Council of Science Editors:

Wolfe P. Tissue Engineering an Acellular Bioresorbable Vascular Graft to Promote Regeneration. [Doctoral Dissertation]. Virginia Commonwealth University; 2011. Available from: https://scholarscompass.vcu.edu/etd/2627

University of Oklahoma

11. Goktas, Selda. Development of a Novel Ex Vivo Scaffold for the Regeneration of Periodontal Tissues.

Degree: PhD, 2011, University of Oklahoma

URL: http://hdl.handle.net/11244/318693

► In order to create functional HUV bioscaffolds for periodontal tissue engineering applications, in vitro 3D culture conditions were developed and optimized. The goal was to… (more)

Subjects/Keywords: Guided tissue regeneration; Vascular grafts; Tissue engineering; Periodontal disease – Treatment

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Goktas, S. (2011). Development of a Novel Ex Vivo Scaffold for the Regeneration of Periodontal Tissues. (Doctoral Dissertation). University of Oklahoma. Retrieved from http://hdl.handle.net/11244/318693

Chicago Manual of Style (16^th Edition):

Goktas, Selda. “Development of a Novel Ex Vivo Scaffold for the Regeneration of Periodontal Tissues.” 2011. Doctoral Dissertation, University of Oklahoma. Accessed July 21, 2019. http://hdl.handle.net/11244/318693.

MLA Handbook (7^th Edition):

Goktas, Selda. “Development of a Novel Ex Vivo Scaffold for the Regeneration of Periodontal Tissues.” 2011. Web. 21 Jul 2019.

Vancouver:

Goktas S. Development of a Novel Ex Vivo Scaffold for the Regeneration of Periodontal Tissues. [Internet] [Doctoral dissertation]. University of Oklahoma; 2011. [cited 2019 Jul 21]. Available from: http://hdl.handle.net/11244/318693.

Council of Science Editors:

Goktas S. Development of a Novel Ex Vivo Scaffold for the Regeneration of Periodontal Tissues. [Doctoral Dissertation]. University of Oklahoma; 2011. Available from: http://hdl.handle.net/11244/318693

Cal Poly

12. Berry, Carolyn. DESIGN AND DEVELOPMENT OF TWO TEST FIXTURES TO TEST THE LONGITUDINAL AND TRANSVERSE TENSILE PROPERTIES OF SMALL DIAMETER TUBULAR POLYMERS.

Degree: MS, Biomedical and General Engineering, 2011, Cal Poly

URL: https://digitalcommons.calpoly.edu/theses/494 ; 10.15368/theses.2011.49

► Hundreds of thousands of vascular bypass grafts are implanted in the United States every year, but there has yet to be an ideal graft… (more)

▼ Hundreds of thousands of vascular bypass grafts are implanted in the United States every year, but there has yet to be an ideal graft material to substitute for one’s own autologous vessel. Many synthetic materials have been shown to be successful vessel replacements; however, none have been proven to exhibit the same mechanical properties as native vessels, one of the most important criteria in selecting a vascular graft material. Part of this issue is due to the fact that, currently, there is no “gold standard” for testing the longitudinal and transverse tensile properties of small diameter tubular materials. While there are ASTM and ISO standards that suggest ways to test tubes in their original form, many researchers have published tensile strength data based on cutting the tube and testing it as a flat sample. Thus, it was the aim of this thesis to understand, establish, and implement accurate tensile testing methods of small diameter polymers in their original, tubular state on Cal Poly’s campus. Two test fixtures were created based on specified design criteria in order to test materials in their tubular form in both the longitudinal and transverse directions. Both fixtures were successful in testing PLGA and ePTFE samples, and statistical data was gathered for the transverse test fixture. The new transverse test fixture was tested against the current method of testing, and a significant (α = 0.05) difference between methods was established for ultimate tensile strength. This analysis, however, cannot determine which test method is more accurate, thus more extensive testing is required to verify the design of both fixtures. By developing a method for testing small diameter polymers in tubular form on Cal Poly’s campus, it allows for more testing of various small diameter tubes and more comparative data to validate each design. It also demonstrates a need for a more detailed and widespread standardization of testing for small diameter tubes, especially in vascular substitute applications where the ideal vessel replacement has yet to be found. Advisors/Committee Members: Kristen O'Halloran Cardinal.

Subjects/Keywords: tensile properties; tubular polymers; vascular grafts; tensile testing; Biomaterials

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APA (6^th Edition):

Berry, C. (2011). DESIGN AND DEVELOPMENT OF TWO TEST FIXTURES TO TEST THE LONGITUDINAL AND TRANSVERSE TENSILE PROPERTIES OF SMALL DIAMETER TUBULAR POLYMERS. (Masters Thesis). Cal Poly. Retrieved from https://digitalcommons.calpoly.edu/theses/494 ; 10.15368/theses.2011.49

Chicago Manual of Style (16^th Edition):

Berry, Carolyn. “DESIGN AND DEVELOPMENT OF TWO TEST FIXTURES TO TEST THE LONGITUDINAL AND TRANSVERSE TENSILE PROPERTIES OF SMALL DIAMETER TUBULAR POLYMERS.” 2011. Masters Thesis, Cal Poly. Accessed July 21, 2019. https://digitalcommons.calpoly.edu/theses/494 ; 10.15368/theses.2011.49.

MLA Handbook (7^th Edition):

Berry, Carolyn. “DESIGN AND DEVELOPMENT OF TWO TEST FIXTURES TO TEST THE LONGITUDINAL AND TRANSVERSE TENSILE PROPERTIES OF SMALL DIAMETER TUBULAR POLYMERS.” 2011. Web. 21 Jul 2019.

Vancouver:

Berry C. DESIGN AND DEVELOPMENT OF TWO TEST FIXTURES TO TEST THE LONGITUDINAL AND TRANSVERSE TENSILE PROPERTIES OF SMALL DIAMETER TUBULAR POLYMERS. [Internet] [Masters thesis]. Cal Poly; 2011. [cited 2019 Jul 21]. Available from: https://digitalcommons.calpoly.edu/theses/494 ; 10.15368/theses.2011.49.

Council of Science Editors:

Berry C. DESIGN AND DEVELOPMENT OF TWO TEST FIXTURES TO TEST THE LONGITUDINAL AND TRANSVERSE TENSILE PROPERTIES OF SMALL DIAMETER TUBULAR POLYMERS. [Masters Thesis]. Cal Poly; 2011. Available from: https://digitalcommons.calpoly.edu/theses/494 ; 10.15368/theses.2011.49

Queen Mary, University of London

13. Qui, Lin. Interaction between vascular endothelial cells and surface textured biomaterials.

Degree: PhD, 2014, Queen Mary, University of London

URL: http://qmro.qmul.ac.uk/xmlui/handle/123456789/8854 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667301

► A promising approach to overcome thrombus and neointima formation on vascular grafts is to create a functional, quiescent monolayer of endothelial cells on the surface… (more)

▼ A promising approach to overcome thrombus and neointima formation on vascular grafts is to create a functional, quiescent monolayer of endothelial cells on the surface of implants. Surface topography of these implants is proven to enhance cell attachment and to reduce the inflammation associated with a smooth surface. Photoembossing is a relatively new, simple, environment-friendly and cost-effective technique to create surface topographies, since there is no etching step or mould needed. In this study, photopolymer films are photoembossed through contact mask photoembossing, while fibres are photoembossed through holographic lithography. Surface relief textures of ridges and grooves with various pitch sizes and heights are successfully obtained through both methods. Furthermore, we introduce this technique to fabricate, for the first time, reproducible surface textures on electrospun fibres. Human umbilical vein endothelial cells (HUVECs) are used in the study. Three different systems are investigated: non-degradable PMMA-TPETA, semi-degradable PLGA-TPETA and fully degradable PLGA-PEGDA-DTT, for different applications and therapeutic requirements. Both non-degradable PMMA-TPETA photopolymer and semi-degradable PLGA-TPETA photopolymer are shown to improve biocompatibility compared to PMMA and PLGA, respectively. Photoembossed films made from these two photopolymers show significantly improved cell attachment and proliferation, IV with a water contact angle around 70º. It is shown that the pitch size of surface topographies affects cell adhesion and migration in the wound healing assay study. Interaction between HUVECs and fibres shows that cells grow from their initial locations at fibre crossings. Focal adhesions are seen to be more aggregated on the surface textured fibres, while those on the glass cover slips are more dispersed near the edge of the cell membrane. The appearance of F-actin in the cytoplasm is also seen to be influenced by the surface topography, where changes in the diameter of the fibre and its surface texture result in F-actin rearrangement. Our study shows that a surface textured, fully degradable, gel-like photopolymer PLGA-PEGDA-DTT has great potential to be further developed for tissue engineering applications.

Subjects/Keywords: 610.28; Materials Science; Vascular grafts; Tissue Engineering; Biomaterials; Bioengineering

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APA (6^th Edition):

Qui, L. (2014). Interaction between vascular endothelial cells and surface textured biomaterials. (Doctoral Dissertation). Queen Mary, University of London. Retrieved from http://qmro.qmul.ac.uk/xmlui/handle/123456789/8854 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667301

Chicago Manual of Style (16^th Edition):

Qui, Lin. “Interaction between vascular endothelial cells and surface textured biomaterials.” 2014. Doctoral Dissertation, Queen Mary, University of London. Accessed July 21, 2019. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8854 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667301.

MLA Handbook (7^th Edition):

Qui, Lin. “Interaction between vascular endothelial cells and surface textured biomaterials.” 2014. Web. 21 Jul 2019.

Vancouver:

Qui L. Interaction between vascular endothelial cells and surface textured biomaterials. [Internet] [Doctoral dissertation]. Queen Mary, University of London; 2014. [cited 2019 Jul 21]. Available from: http://qmro.qmul.ac.uk/xmlui/handle/123456789/8854 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667301.

Council of Science Editors:

Qui L. Interaction between vascular endothelial cells and surface textured biomaterials. [Doctoral Dissertation]. Queen Mary, University of London; 2014. Available from: http://qmro.qmul.ac.uk/xmlui/handle/123456789/8854 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667301

14. Burrows, Mariana Carvalho. Suportes híbridos de PET e colágeno como modelo para enxertia vascular.

Degree: Mestrado, Química Orgânica, 2011, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/46/46135/tde-25042011-133342/ ;

►

Suportes eletrofiados para crescimento celular são de interesse para a engenharia de tecidos, principalmente em função de sua estrutura em forma de rede tridimensional de… (more)

▼

Suportes eletrofiados para crescimento celular são de interesse para a engenharia de tecidos, principalmente em função de sua estrutura em forma de rede tridimensional de fibras de diâmetro nanométrico. Esta arquitetura especial permite a geração de elevada área superficial e porosidade, características importantes para a adesão, proliferação e infiltração de células para o interior do suporte. A utilização de um suporte eletrofiado como enxerto vascular necessita ainda que este apresente excelentes propriedades mecânicas, associadas a uma elevada biocompatibilidade. Neste trabalho mostramos que estas propriedades podem ser alcançadas a partir da eletrofiação de uma co-solução de PET e colágeno gerando um material híbrido, visto que PET apresenta excelentes propriedades mecânicas e o colágeno é o principal componente da matriz extracelular. A obtenção dos suportes eletrofiados de PETcolágeno mostrou ser possível utilizando-se como solvente HFIP e HFIP/TFA 7:2. No entanto, neste último, o colágeno é completamente degradado durante o processo de solubilização. Fixando-se os parâmetros de eletrofiação, a morfologia da malha obtida mostrou ser dependente da relação massa PET/massa colágeno, concentração total da solução e solvente utilizado. Foram obtidos materiais com distribuição de diâmetros unimodal e bimodal, além de materiais com formato em fitas e teias entre as fibras. Ainda, PET e colágeno formam malhas de composição complexa, nas quais são encontradas fibras compostas de materiais puros, mas também formam blendas em que os dois materiais encontram-se misturados em uma mesma fibra. Os materiais S8,2 S4,6 foram caracterizados química-, mecânica- e biologicamente. Observou-se que, para filmes planos, estes materiais apresentaram energia de superfície mais próxima da do colágeno, o que justifica a melhor adesão celular em S8,2 e S4,6 do que no PET. S8,2 mostrou ter valores de módulo de elasticidade e elongação máxima próximos ao da artéria femoral, enquanto que S4,6 apresentou-se como um material quebradiço. Os ensaios de crescimento celular utilizando fibroblastos, um modelo de tecido conjuntivo (linhagem 3T3-L1) e células endoteliais, um modelo de tecido arterial e venoso (HUVECs) comprovaram a excelente adesão e proliferação celular nos suportes celulares. S8,2 apresentou-se como o melhor material frente às células HUVECS, enquanto que S4,6 foi o melhor material frente às células 3T3-L1. Propõe-se a utilização de S8,2 como um biomaterial para enxertia vascular e S4,6 como material de recobrimento de próteses já utilizadas.

Scaffolds obtained by electrospinning for cellular growth are of interest for materials engineering, especially considering its structure in the form of a three-dimensional fiber mesh of nanometric diameter. This special architecture allows the generation of larger surface areas and higher porosity structures, and also important characteristics for the adhesion, proliferation and infiltration of cells into the scaffold. The use of an electrospun scaffold as a vascular graft additionally…

Advisors/Committee Members: Catalani, Luiz Henrique.

Subjects/Keywords: Colágeno; Collagen; Electrospinning; Electrospun scaffolds; Eletrofiação; Enxertos vasculares; PET; PET; Suportes eletrofiados; Vascular grafts

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Burrows, M. C. (2011). Suportes híbridos de PET e colágeno como modelo para enxertia vascular. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/46/46135/tde-25042011-133342/ ;

Chicago Manual of Style (16^th Edition):

Burrows, Mariana Carvalho. “Suportes híbridos de PET e colágeno como modelo para enxertia vascular.” 2011. Masters Thesis, University of São Paulo. Accessed July 21, 2019. http://www.teses.usp.br/teses/disponiveis/46/46135/tde-25042011-133342/ ;.

MLA Handbook (7^th Edition):

Burrows, Mariana Carvalho. “Suportes híbridos de PET e colágeno como modelo para enxertia vascular.” 2011. Web. 21 Jul 2019.

Vancouver:

Burrows MC. Suportes híbridos de PET e colágeno como modelo para enxertia vascular. [Internet] [Masters thesis]. University of São Paulo; 2011. [cited 2019 Jul 21]. Available from: http://www.teses.usp.br/teses/disponiveis/46/46135/tde-25042011-133342/ ;.

Council of Science Editors:

Burrows MC. Suportes híbridos de PET e colágeno como modelo para enxertia vascular. [Masters Thesis]. University of São Paulo; 2011. Available from: http://www.teses.usp.br/teses/disponiveis/46/46135/tde-25042011-133342/ ;

Texas A&M University

15. Dempsey, David Kandell. Development and Characterization of Novel Biomaterials for Fabrication of Multilayered Vascular Grafts.

Degree: 2013, Texas A&M University

URL: http://hdl.handle.net/1969.1/151874

► Current synthetic alternatives to autologous grafts have often failed in small diameter applications (<6 mm) due to their thrombogenicity and compliance mismatch of native vasculature.… (more)

▼ Current synthetic alternatives to autologous grafts have often failed in small diameter applications (<6 mm) due to their thrombogenicity and compliance mismatch of native vasculature. No known synthetic material is capable of providing a non-thrombogenic inner layer that promotes endothelial cell (EC) interactions while also providing sufficient compliance and burst pressure for long term success in vivo. We have developed a multilayer design with an inner thromboresistant poly(ethylene glycol) (PEG) hydrogel based on Scl2-2 proteins designed to promote rapid in situ endothelialization. The bioactive component is reinforced with an electrospun segmented polyurethane (SPU) layer with tunable mechanical properties to withstand physiological loading conditions. The modulating of electrospun parameters to influence graft architecture coupled with the tunability of SPU mechanical performance is expected to give rise to improved graft biomechanical properties. Unfortunately, this advantage was found to be limited to only one property at a time. To this end, we have developed a novel semi-IPN approach to expand the range of possible graft compliance and burst pressures in order to simultaneously achieve biomechanical properties that exceed autologous veins. In addition to matching biomechanical properties, probability of long term success is also dependent on the grafts retention of perfomance despite cell-mediated attack. Typically, in the case poly(ether urethanes) (PEUs) and poly(carbonate urethanes) (PCUs), oxidative stability is the primary focus in the development of biostable SPUs. We have characterized the biostability of several commercially available polyurethanes while simultaneously evaluating the predictive capabilities of two main in vitro test methods to optimize our graft?s design. Despite ensured long term performance through optimizing biostability, a permanent scaffold prevents vasoactivity, a key function of vasculature. We have taken a tissue engineering approach to restorate vasoactivity by evaluating a novel aromatic biodegradable poly(ester urethane) (PEsU) for the reinforcing layer of a tissue engineering vascular graft (TEVG). This PEsU was expected to degrade into safe byproducts given its design based on glycolic acid and ethylene glycol. Following characterization, the PEsU was determined to be a strong potential reinforcing layer of a potential TEVG design. In summary, we have improved small diameter grafts through a multilayer design approach. Our graft demonstrated favorable initial fabrication feasibility, promising in vivo testing, biomechanical properties exceeding autologous veins, and strong oxidative stability. Overall, we have optimized the reinforcing layer through improvement of biomechanical properties via modulated material chemistry, optimized biostability, and identification of a biodegradable component expected to allow for restored vasoactivity. Advisors/Committee Members: Cosgriff-Hernandez, Elizabeth M (advisor), Grunlan, Melissa (committee member), Maitland, Duncan (committee member), Hahn, Mariah (committee member).

Subjects/Keywords: Coronary Artery Disease; small diameter vascular grafts; polyurethanes; semi-interpenetrating networks; oxidation; hydrolysis; electrospinning

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APA (6^th Edition):

Dempsey, D. K. (2013). Development and Characterization of Novel Biomaterials for Fabrication of Multilayered Vascular Grafts. (Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/151874

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Dempsey, David Kandell. “Development and Characterization of Novel Biomaterials for Fabrication of Multilayered Vascular Grafts.” 2013. Thesis, Texas A&M University. Accessed July 21, 2019. http://hdl.handle.net/1969.1/151874.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Dempsey, David Kandell. “Development and Characterization of Novel Biomaterials for Fabrication of Multilayered Vascular Grafts.” 2013. Web. 21 Jul 2019.

Vancouver:

Dempsey DK. Development and Characterization of Novel Biomaterials for Fabrication of Multilayered Vascular Grafts. [Internet] [Thesis]. Texas A&M University; 2013. [cited 2019 Jul 21]. Available from: http://hdl.handle.net/1969.1/151874.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Dempsey DK. Development and Characterization of Novel Biomaterials for Fabrication of Multilayered Vascular Grafts. [Thesis]. Texas A&M University; 2013. Available from: http://hdl.handle.net/1969.1/151874

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Georgia Tech

16. Schutte, Stacey C. A study of strength and vasoactivity in a tissue engineered vascular media.

Degree: PhD, Mechanical Engineering, 2009, Georgia Tech

URL: http://hdl.handle.net/1853/28241

► To be successful a tissue engineered small diameter blood vessel must be non-immunogenic, non-thrombogenic, have mechanical properties similar to native vessel and be vasoactive. The… (more)

▼ To be successful a tissue engineered small diameter blood vessel must be non-immunogenic, non-thrombogenic, have mechanical properties similar to native vessel and be vasoactive. The vascular media is responsible for the mechanical properties and the vasoactivity of the vessel. The collagen hydrogel approach has been long used and has many advantages, but has not yet achieved the mechanical integrity needed for implantation. No collagen-based tissue engineered vascular media has been shown to be vasoactive using culture techniques required to achieve the cell numbers needed to make a vascular graft. To study collagen synthesis, two model systems were used. Cells were seeded on top of an adsorbed collagen I or fibrin layer. Alternatively the cells were encapsulated in a collagen or fibrin hydrogel. Collagen I, decorin and biglycan synthesis was affected by both matrix type and presentation. After two weeks in culture the smooth muscle cells produce more type I collagen in the collagen based hydrogels then in the fibrin hydrogels and was used for further studies. The collagen based tissue engineered vascular media produced a consistent vasoactive response between two and eight weeks of culture. The smooth muscle cells have functional endothelin, kinin, adrenergic, serotonergic and purinergic receptors. The application of cyclic strain improves both the tissue strength and the contractile response. Use of transforming growth factor-β improved tissue strength, but reduced the contractile response. Transforming growth factor- β actually promoted a more contractile cell phenotype, but a stronger contractile force was required to overcome the thick compact collagen hydrogel and elicit a measurable contraction. This work adds to what is known about collagen-based tissue engineered vascular medias by identifying means of improving not only strength but vasoactivity. The trade-offs found between these two important characteristics are relevant to all tissue engineered medias. Advisors/Committee Members: Nerem, Robert M. (Committee Chair), Gleason, Rudolf L. (Committee Member), Taylor, W. Robert (Committee Member), Vito, Raymond P. (Committee Member), Wang, Yadong (Committee Member).

Subjects/Keywords: Cardiovascular; Tissue engineering; Regenerative medicine; Vascular grafts; Blood-vessels; Blood vessel prosthesis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Schutte, S. C. (2009). A study of strength and vasoactivity in a tissue engineered vascular media. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/28241

Chicago Manual of Style (16^th Edition):

Schutte, Stacey C. “A study of strength and vasoactivity in a tissue engineered vascular media.” 2009. Doctoral Dissertation, Georgia Tech. Accessed July 21, 2019. http://hdl.handle.net/1853/28241.

MLA Handbook (7^th Edition):

Schutte, Stacey C. “A study of strength and vasoactivity in a tissue engineered vascular media.” 2009. Web. 21 Jul 2019.

Vancouver:

Schutte SC. A study of strength and vasoactivity in a tissue engineered vascular media. [Internet] [Doctoral dissertation]. Georgia Tech; 2009. [cited 2019 Jul 21]. Available from: http://hdl.handle.net/1853/28241.

Council of Science Editors:

Schutte SC. A study of strength and vasoactivity in a tissue engineered vascular media. [Doctoral Dissertation]. Georgia Tech; 2009. Available from: http://hdl.handle.net/1853/28241

Texas Tech University

17. Zuniga, Patricia O. Enhanced selectivity of a multifunctional biocatalyst, plasmin.

Degree: MS, Chemical Engineering, 1985, Texas Tech University

URL: http://hdl.handle.net/2346/59390

Subjects/Keywords: Plasmin; Fibrinolytic agents; Vascular grafts; Collagen

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APA (6^th Edition):

Zuniga, P. O. (1985). Enhanced selectivity of a multifunctional biocatalyst, plasmin. (Masters Thesis). Texas Tech University. Retrieved from http://hdl.handle.net/2346/59390

Chicago Manual of Style (16^th Edition):

Zuniga, Patricia O. “Enhanced selectivity of a multifunctional biocatalyst, plasmin.” 1985. Masters Thesis, Texas Tech University. Accessed July 21, 2019. http://hdl.handle.net/2346/59390.

MLA Handbook (7^th Edition):

Zuniga, Patricia O. “Enhanced selectivity of a multifunctional biocatalyst, plasmin.” 1985. Web. 21 Jul 2019.

Vancouver:

Zuniga PO. Enhanced selectivity of a multifunctional biocatalyst, plasmin. [Internet] [Masters thesis]. Texas Tech University; 1985. [cited 2019 Jul 21]. Available from: http://hdl.handle.net/2346/59390.

Council of Science Editors:

Zuniga PO. Enhanced selectivity of a multifunctional biocatalyst, plasmin. [Masters Thesis]. Texas Tech University; 1985. Available from: http://hdl.handle.net/2346/59390

University of Missouri – Columbia

18. Ostdiek, Allison M. Development of a nanomaterial-tissue patch for vascular and cardiac reconstruction.

Degree: 2014, University of Missouri – Columbia

URL: http://hdl.handle.net/10355/45772

Subjects/Keywords: Biomedical materials; Vascular grafts; Vascular endothelial cells; Nanostructured materials

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APA (6^th Edition):

Ostdiek, A. M. (2014). Development of a nanomaterial-tissue patch for vascular and cardiac reconstruction. (Thesis). University of Missouri – Columbia. Retrieved from http://hdl.handle.net/10355/45772

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ostdiek, Allison M. “Development of a nanomaterial-tissue patch for vascular and cardiac reconstruction.” 2014. Thesis, University of Missouri – Columbia. Accessed July 21, 2019. http://hdl.handle.net/10355/45772.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ostdiek, Allison M. “Development of a nanomaterial-tissue patch for vascular and cardiac reconstruction.” 2014. Web. 21 Jul 2019.

Vancouver:

Ostdiek AM. Development of a nanomaterial-tissue patch for vascular and cardiac reconstruction. [Internet] [Thesis]. University of Missouri – Columbia; 2014. [cited 2019 Jul 21]. Available from: http://hdl.handle.net/10355/45772.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ostdiek AM. Development of a nanomaterial-tissue patch for vascular and cardiac reconstruction. [Thesis]. University of Missouri – Columbia; 2014. Available from: http://hdl.handle.net/10355/45772

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

North Carolina State University

19. Moghe, Ajit Keshav. Study and Characterization of Small Diameter Woven Tubular Fabrics.

Degree: MS, Textile Engineering, 2003, North Carolina State University

URL: http://www.lib.ncsu.edu/resolver/1840.16/1468

► Woven tubular structures have been used since 1950s as vascular grafts in repairing damaged or diseased arteries and veins. The grafts for large caliber blood… (more)

Subjects/Keywords: medical textiles; textile biomaterials; artificial arteries; vascular grafts; arterial grafts; tubular structures

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APA (6^th Edition):

Moghe, A. K. (2003). Study and Characterization of Small Diameter Woven Tubular Fabrics. (Thesis). North Carolina State University. Retrieved from http://www.lib.ncsu.edu/resolver/1840.16/1468

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Moghe, Ajit Keshav. “Study and Characterization of Small Diameter Woven Tubular Fabrics.” 2003. Thesis, North Carolina State University. Accessed July 21, 2019. http://www.lib.ncsu.edu/resolver/1840.16/1468.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Moghe, Ajit Keshav. “Study and Characterization of Small Diameter Woven Tubular Fabrics.” 2003. Web. 21 Jul 2019.

Vancouver:

Moghe AK. Study and Characterization of Small Diameter Woven Tubular Fabrics. [Internet] [Thesis]. North Carolina State University; 2003. [cited 2019 Jul 21]. Available from: http://www.lib.ncsu.edu/resolver/1840.16/1468.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Moghe AK. Study and Characterization of Small Diameter Woven Tubular Fabrics. [Thesis]. North Carolina State University; 2003. Available from: http://www.lib.ncsu.edu/resolver/1840.16/1468

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Gothenburg / Göteborgs Universitet

20. Fink, Helen. Artificial blood vessels - Studies on endothelial cell and blood interactions with bacterial cellulose.

Degree: 2009, University of Gothenburg / Göteborgs Universitet

URL: http://hdl.handle.net/2077/21217

► Cardiovascular diseases are still the number one cause of death or invalidity in the western world today. Atherosclerotic plaques and restenosis can result in severe… (more)

▼ Cardiovascular diseases are still the number one cause of death or invalidity in the western world today. Atherosclerotic plaques and restenosis can result in severe occlusions of peripheral and coronary arteries. Treatment depends on the severity of the disease and includes drug therapy and bypass surgery. Generally, autologous vessels are used as replacement grafts and are the first choices as vascular graft materials. However, if the patient does not have vessels with sufficient quality, as a result of previous operations or other diseases, artificial grafts may be used to replace vessels. Today’s materials are limited to substitute large vessels (>5 mm) because of frequent thrombosis and occlusion of small diameter grafts. About 10% of patients with coronary artery disease are therefore left untreated. Considering the high number of patients in the need of replacement grafts, the demand for an alternative small-caliber graft is enormous and has driven scientist to search for new materials. Bacterial cellulose (BC) has unique qualities and is an interesting material for vascular grafts. In this thesis, bacterial cellulose has been investigated as a potential new vascular graft material by evaluating cell and blood interactions with BC. The specific aims were to evaluate if surface modifications could promote human endothelial cells and to investigate the thrombogenic properties of BC compared to conventional graft materials. Modification of BC with a novel technique, were xyloglucan is used as a carrier molecule for the adhesion-promoting peptide RGD, resulted in increased cell adhesion, metabolism and cell spreading. Luminal coating of BC-tubes with fibrin glue resulted in increased cell adhesion during static experiments and good cell retention during physiological shear stress. The evaluation of thrombogenicity in human blood plasma revealed that BC induces a slower coagulation compared with clinically available materials such as Gore-Tex® and Dacron®. In addition, BC induced the least contact activation evaluated by XIIa generation. A Chandler loop system with freshly drawn blood showed that BC consumed low amounts of platelets and generated low thrombin values compared with Dacron® and Gore-Tex®. This Thesis shows that BC is a promising, novel vascular graft material based on low thrombogenicity and promising endothelial cell adhesion.

Subjects/Keywords: bacterial cellulose; endothelial cells; thrombogenicity; xyloglucan; contact activation; imaging of coagulation; vascular grafts; RGD; cell adhesion; bioreactor

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APA (6^th Edition):

Fink, H. (2009). Artificial blood vessels - Studies on endothelial cell and blood interactions with bacterial cellulose. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/21217

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Fink, Helen. “Artificial blood vessels - Studies on endothelial cell and blood interactions with bacterial cellulose.” 2009. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed July 21, 2019. http://hdl.handle.net/2077/21217.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Fink, Helen. “Artificial blood vessels - Studies on endothelial cell and blood interactions with bacterial cellulose.” 2009. Web. 21 Jul 2019.

Vancouver:

Fink H. Artificial blood vessels - Studies on endothelial cell and blood interactions with bacterial cellulose. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 2009. [cited 2019 Jul 21]. Available from: http://hdl.handle.net/2077/21217.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Fink H. Artificial blood vessels - Studies on endothelial cell and blood interactions with bacterial cellulose. [Thesis]. University of Gothenburg / Göteborgs Universitet; 2009. Available from: http://hdl.handle.net/2077/21217

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Georgia Tech

21. Kumar, Vivek Ashok. Design and evaluation of scaffolds for arterial grafts using extracellular matrix based materials.

Degree: PhD, Biomedical Engineering, 2011, Georgia Tech

URL: http://hdl.handle.net/1853/45869

► For small diameter (<6 mm) blood vessel replacements, lack of collaterals and vascular disease preclude homografts; while synthetic analogs, ePTFE, expanded polytetrafluoroethylene, and PET, polyethyleneterephathalate,… (more)

Subjects/Keywords: Rat aortic interposition; Rat tail tendon; Vascular; Elastin; Collagen; Soft tissue; Blood vessels; Tissue engineering; Regenerative medicine; Arterial grafts; Tissue scaffolds

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APA (6^th Edition):

Kumar, V. A. (2011). Design and evaluation of scaffolds for arterial grafts using extracellular matrix based materials. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/45869

Chicago Manual of Style (16^th Edition):

Kumar, Vivek Ashok. “Design and evaluation of scaffolds for arterial grafts using extracellular matrix based materials.” 2011. Doctoral Dissertation, Georgia Tech. Accessed July 21, 2019. http://hdl.handle.net/1853/45869.

MLA Handbook (7^th Edition):

Kumar, Vivek Ashok. “Design and evaluation of scaffolds for arterial grafts using extracellular matrix based materials.” 2011. Web. 21 Jul 2019.

Vancouver:

Kumar VA. Design and evaluation of scaffolds for arterial grafts using extracellular matrix based materials. [Internet] [Doctoral dissertation]. Georgia Tech; 2011. [cited 2019 Jul 21]. Available from: http://hdl.handle.net/1853/45869.

Council of Science Editors:

Kumar VA. Design and evaluation of scaffolds for arterial grafts using extracellular matrix based materials. [Doctoral Dissertation]. Georgia Tech; 2011. Available from: http://hdl.handle.net/1853/45869

Georgia Tech

22. Costello, James Robert. Effect of Material Properties and Hemodynamics on the Healing of Vascular Grafts in baboons.

Degree: PhD, Biomedical Engineering, 2004, Georgia Tech

URL: http://hdl.handle.net/1853/5226

► Each year, more than one million prosthetic vascular grafts are implanted. Well-over 50 % of these artificial vessels are of the small caliber variety with… (more)

▼ Each year, more than one million prosthetic vascular grafts are implanted. Well-over 50 % of these artificial vessels are of the small caliber variety with an inner diameter less than or equal to 10 mm. The challenge rests in implanting these synthetic substitutes into a hemodynamic environment with a high downstream resistance and low rates of flow. Over the course of four interrelated studies, we investigated the healing properties of small caliber prosthetic vascular grafts. All of these studies were conducted using baboons. First, we documented the difference in healing response between three different types of vascular grafts: (1) autologous artery (2) allogeneic vessel (3) prosthetic ePTFE. This comparison furnished an important model of graft healing. Proliferating endothelial cells were localized to the top 10 % of the neointima, while the proliferating smooth muscle cells were identified within the lower 10 % of the neointima. Secondly, we examined the effects of changing a prosthetic grafts material properties and how that change impacts healing of the grafts surface. These ultrastructural changes were introduced by radially stretching a porous 60 mm ePTFE vascular graft. Radially stretching the graft material decreased the void fraction, reduced the potential for transmural ingrowth, and changed the healing characteristics of the implanted vessels. Thirdly, we investigated the effect of a changing hemodynamic environment upon the healing of a vascular graft with uniform material properties. The changing hemodynamics were generated with a stenotic model. Under sub-acute conditions, an inverse relationship failed to exist between intimal thickening and wall shear stress. Lastly, the details of this hemodynamic environment were documented with computational fluid dynamics (CFD). The computational grids were constructed using three sets of geometric information: (1) incorporating the ideal material dimensions of the implanted vessel (2) utilizing contour information from pressure-perfused histologic cross-sections (3) applying geometric information form detailed MRI imaging. MRI imaging information provided the best description of the vessels hemodynamic environment. With this computational information, correlations were made between the intimal thickening and hemodynamic parameters. Advisors/Committee Members: Don P. Giddens (Committee Co-Chair), Stephen R. Hanson (Committee Co-Chair), Changyi Chen (Committee Member), Hanjoong Jo (Committee Member), Robert Nerem (Committee Member).

Subjects/Keywords: CFD; MRI imaging; Hemodynamics; ePTFE; Prosthetic vascular grafts

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Costello, J. R. (2004). Effect of Material Properties and Hemodynamics on the Healing of Vascular Grafts in baboons. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/5226

Chicago Manual of Style (16^th Edition):

Costello, James Robert. “Effect of Material Properties and Hemodynamics on the Healing of Vascular Grafts in baboons.” 2004. Doctoral Dissertation, Georgia Tech. Accessed July 21, 2019. http://hdl.handle.net/1853/5226.

MLA Handbook (7^th Edition):

Costello, James Robert. “Effect of Material Properties and Hemodynamics on the Healing of Vascular Grafts in baboons.” 2004. Web. 21 Jul 2019.

Vancouver:

Costello JR. Effect of Material Properties and Hemodynamics on the Healing of Vascular Grafts in baboons. [Internet] [Doctoral dissertation]. Georgia Tech; 2004. [cited 2019 Jul 21]. Available from: http://hdl.handle.net/1853/5226.

Council of Science Editors:

Costello JR. Effect of Material Properties and Hemodynamics on the Healing of Vascular Grafts in baboons. [Doctoral Dissertation]. Georgia Tech; 2004. Available from: http://hdl.handle.net/1853/5226

23. HE WEI. Electrospun Nanofibre Scaffolds for Tissue Engineered Small-Diameter Vascular Grafts.

Degree: 2008, National University of Singapore

URL: http://scholarbank.nus.edu.sg/handle/10635/16104

Subjects/Keywords: electrospinning; nanofibers; tissue engineering; vascular grafts. scaffolds

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APA (6^th Edition):

WEI, H. (2008). Electrospun Nanofibre Scaffolds for Tissue Engineered Small-Diameter Vascular Grafts. (Thesis). National University of Singapore. Retrieved from http://scholarbank.nus.edu.sg/handle/10635/16104

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

WEI, HE. “Electrospun Nanofibre Scaffolds for Tissue Engineered Small-Diameter Vascular Grafts.” 2008. Thesis, National University of Singapore. Accessed July 21, 2019. http://scholarbank.nus.edu.sg/handle/10635/16104.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

WEI, HE. “Electrospun Nanofibre Scaffolds for Tissue Engineered Small-Diameter Vascular Grafts.” 2008. Web. 21 Jul 2019.

Vancouver:

WEI H. Electrospun Nanofibre Scaffolds for Tissue Engineered Small-Diameter Vascular Grafts. [Internet] [Thesis]. National University of Singapore; 2008. [cited 2019 Jul 21]. Available from: http://scholarbank.nus.edu.sg/handle/10635/16104.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

WEI H. Electrospun Nanofibre Scaffolds for Tissue Engineered Small-Diameter Vascular Grafts. [Thesis]. National University of Singapore; 2008. Available from: http://scholarbank.nus.edu.sg/handle/10635/16104

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

North Carolina State University

24. Agrawal, Pankaj. Design And Study of Biodegradable Small Diameter Vascular Grafts.

Degree: MS, Textile Engineering, 2003, North Carolina State University

URL: http://www.lib.ncsu.edu/resolver/1840.16/1362

► In this research, the focus has been on designing and producing small diameter woven grafts having a biodegradable material. Woven tubes in diameters ranging from… (more)

Subjects/Keywords: Woven Vascular Grafts; medical textiles; Polyglactin 910; PLGA; Biodegradable

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APA (6^th Edition):

Agrawal, P. (2003). Design And Study of Biodegradable Small Diameter Vascular Grafts. (Thesis). North Carolina State University. Retrieved from http://www.lib.ncsu.edu/resolver/1840.16/1362

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Agrawal, Pankaj. “Design And Study of Biodegradable Small Diameter Vascular Grafts.” 2003. Thesis, North Carolina State University. Accessed July 21, 2019. http://www.lib.ncsu.edu/resolver/1840.16/1362.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Agrawal, Pankaj. “Design And Study of Biodegradable Small Diameter Vascular Grafts.” 2003. Web. 21 Jul 2019.

Vancouver:

Agrawal P. Design And Study of Biodegradable Small Diameter Vascular Grafts. [Internet] [Thesis]. North Carolina State University; 2003. [cited 2019 Jul 21]. Available from: http://www.lib.ncsu.edu/resolver/1840.16/1362.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Agrawal P. Design And Study of Biodegradable Small Diameter Vascular Grafts. [Thesis]. North Carolina State University; 2003. Available from: http://www.lib.ncsu.edu/resolver/1840.16/1362

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Arizona

25. Cardinal, Kristen O'Halloran. Development and Utilization of a Tissue Engineered Blood Vessel Mimic to Assess the Neointimal Response to Intravascular Stents .

Degree: 2007, University of Arizona

URL: http://hdl.handle.net/10150/195387

► The use of intravascular stents to restore blood flow through restricted vessels in patients with coronary artery disease has become the preferred method for treating… (more)

▼ The use of intravascular stents to restore blood flow through restricted vessels in patients with coronary artery disease has become the preferred method for treating a variety of lesion locations and pathologies. As new stent configurations and coatings are developed, a great need exists for high-throughput preclinical evaluation techniques that can interface human tissue with three-dimensional devices. Thus, the goals of this dissertation research were 1) to develop an in vitro blood vessel mimic composed of human cells for preclinical evaluation of intravascular devices, and 2) to utilize the mimic to assess neointimal responses to implanted stents.Experiments in support of these goals were broken into four specific aims. The first aim was to develop an in vitro human blood vessel mimic based on techniques for creating tissue engineered vascular grafts. The second aim was to determine the feasibility of utilizing this vessel mimic for bare metal stent evaluation. The third aim was to use the in vitro vessel to evaluate the cellular response to protein-coated stents. The fourth aim was to take advantage of the ability to control the in vitro vessel environment in order to evaluate the effect of shear rate on the neointimal response to implanted stents.Human blood vessel mimics were created by sodding fat-derived microvascular endothelial cells onto expanded polytetrafluoroethylene grafts and cultivating the vessels in bioreactor systems. This resulted in the development of a luminal lining of endothelial cells with sub-endothelial smooth muscle and mesenchymal cells. Deployment and assessment of bare metal stents within blood vessel mimics supported the feasibility of using the model for stent evaluation, and demonstrated that cell coverage of the device surface could be observed and measured. Protein-modified stents were created by submerging devices in enriched medium, and following implantation in the blood vessel mimic exhibited increased cell coverage and increased tissue thickness as compared with bare metal stents. Finally, an increase in shear rate lead to decreased neointimal coverage of implanted bare metal and modified stents. Overall, this dissertation demonstrates that in vitro human blood vessel mimics can be created and utilized for preclinical device evaluation. Advisors/Committee Members: Williams, Stuart K. (committeemember), Hoying, James (committeemember), Riley, Mark (committeemember), Hossainy, Syed (committeemember), Berman, Scott (committeemember).

Subjects/Keywords: tissue engineered vascular grafts; stents; endothelial cells

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cardinal, K. O. (2007). Development and Utilization of a Tissue Engineered Blood Vessel Mimic to Assess the Neointimal Response to Intravascular Stents . (Doctoral Dissertation). University of Arizona. Retrieved from http://hdl.handle.net/10150/195387

Chicago Manual of Style (16^th Edition):

Cardinal, Kristen O'Halloran. “Development and Utilization of a Tissue Engineered Blood Vessel Mimic to Assess the Neointimal Response to Intravascular Stents .” 2007. Doctoral Dissertation, University of Arizona. Accessed July 21, 2019. http://hdl.handle.net/10150/195387.

MLA Handbook (7^th Edition):

Cardinal, Kristen O'Halloran. “Development and Utilization of a Tissue Engineered Blood Vessel Mimic to Assess the Neointimal Response to Intravascular Stents .” 2007. Web. 21 Jul 2019.

Vancouver:

Cardinal KO. Development and Utilization of a Tissue Engineered Blood Vessel Mimic to Assess the Neointimal Response to Intravascular Stents . [Internet] [Doctoral dissertation]. University of Arizona; 2007. [cited 2019 Jul 21]. Available from: http://hdl.handle.net/10150/195387.

Council of Science Editors:

Cardinal KO. Development and Utilization of a Tissue Engineered Blood Vessel Mimic to Assess the Neointimal Response to Intravascular Stents . [Doctoral Dissertation]. University of Arizona; 2007. Available from: http://hdl.handle.net/10150/195387

Georgia Tech

26. Williams, Chrysanthi. Perfusion bioreactor for tissue-engineered blood vessels.

Degree: PhD, Bioengineering, 2003, Georgia Tech

URL: http://hdl.handle.net/1853/9455

Subjects/Keywords: Tissue engineering; Bioreactors Design and construction; Vascular grafts; Vascular grafts; Tissue engineering; Bioreactors Design and construction

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Williams, C. (2003). Perfusion bioreactor for tissue-engineered blood vessels. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/9455

Chicago Manual of Style (16^th Edition):

Williams, Chrysanthi. “Perfusion bioreactor for tissue-engineered blood vessels.” 2003. Doctoral Dissertation, Georgia Tech. Accessed July 21, 2019. http://hdl.handle.net/1853/9455.

MLA Handbook (7^th Edition):

Williams, Chrysanthi. “Perfusion bioreactor for tissue-engineered blood vessels.” 2003. Web. 21 Jul 2019.

Vancouver:

Williams C. Perfusion bioreactor for tissue-engineered blood vessels. [Internet] [Doctoral dissertation]. Georgia Tech; 2003. [cited 2019 Jul 21]. Available from: http://hdl.handle.net/1853/9455.

Council of Science Editors:

Williams C. Perfusion bioreactor for tissue-engineered blood vessels. [Doctoral Dissertation]. Georgia Tech; 2003. Available from: http://hdl.handle.net/1853/9455

27. Zahedmanesh, Houman. Finite element and mechanobiological modelling of vascular devices.

Degree: School of Mechanical and Manufacturing Engineering, 2011, Dublin City University

URL: http://doras.dcu.ie/16470/

► There are two main surgical treatments for vascular diseases, (i) percutaneous stent deployment and (ii) replacement of an atherosclerotic artery with a vascular graft or… (more)

▼ There are two main surgical treatments for vascular diseases, (i) percutaneous stent deployment and (ii) replacement of an atherosclerotic artery with a vascular graft or tissue engineered blood vessel. The aim of this thesis was to develop computational models that could assist in the design of vascular stents and tissue engineered vascular grafts and scaffolds. In this context, finite element (FE) models of stent expansion in idealised and patient specific models of atherosclerotic arteries were developed. Different modelling strategies were investigated and an optimal modelling approach was identified which minimised computational cost without compromising accuracy. Numerical models of thin and thick strut stents were developed using this modelling approach to replicate the ISAR-STEREO clinical trial and the models identified arterial stresses as a suitable measure of stent induced vascular injury. In terms of evaluating vascular graft performance, mechanical characterisation experiments can be conducted in order to develop constitutive models that can be used in FE models of vascular grafts to predict their mechanical behaviour in-situ. In this context, bacterial cellulose (BC), a novel biomaterial, was mechanically characterised and a constitutive model was developed to describe its mechanical response. In addition, the interaction of smooth muscle cells with BC was studied using cell culture experiments. The constitutive model developed for BC was used as an input for a novel multi-scale mechanobiological modelling framework. The mechanobiological model was developed by coupling an FE model of a vascular scaffold and a lattice free agent based model of cell growth dynamics and remodelling in vascular scaffolds. By comparison with published in-vivo and in-vitro works, the model was found to successfully capture the key characteristics of vascular remodelling. It can therefore be used as a predictive tool for the growth and remodelling of vascular scaffolds and grafts Advisors/Committee Members: Lally, Caitríona.

Subjects/Keywords: Biomedical engineering; atherosclerotic arteries; computational models; design; vascular stents; tissue engineered vascular grafts; vascular scaffolds

…tissue engineered vascular grafts and scaffolds. In this context, finite element (FE)… …that can be used in FE models of vascular grafts to predict their mechanical behaviour in… …including balloon angioplasty and stent deployment. 1.2 Objectives Vascular grafts and stents are… …biomechanics related challenges in relation to vascular grafts and stents, (also see Figure 1-1… …mechanical properties of vascular grafts and their design to minimise renarrowing of grafts…

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APA (6^th Edition):

Zahedmanesh, H. (2011). Finite element and mechanobiological modelling of vascular devices. (Thesis). Dublin City University. Retrieved from http://doras.dcu.ie/16470/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Zahedmanesh, Houman. “Finite element and mechanobiological modelling of vascular devices.” 2011. Thesis, Dublin City University. Accessed July 21, 2019. http://doras.dcu.ie/16470/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Zahedmanesh, Houman. “Finite element and mechanobiological modelling of vascular devices.” 2011. Web. 21 Jul 2019.

Vancouver:

Zahedmanesh H. Finite element and mechanobiological modelling of vascular devices. [Internet] [Thesis]. Dublin City University; 2011. [cited 2019 Jul 21]. Available from: http://doras.dcu.ie/16470/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Zahedmanesh H. Finite element and mechanobiological modelling of vascular devices. [Thesis]. Dublin City University; 2011. Available from: http://doras.dcu.ie/16470/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

28. Munoz Pinto, Dany 1981-. Hybrid Polyethylene Glycol Hydrogels for Tissue Engineering Applications.

Degree: 2012, Texas A&M University

URL: http://hdl.handle.net/1969.1/149213

► Currently, organ transplant procedures are insufficient to address the needs of the number of patients that suffer of organ failure related disease. In the United… (more)

▼ Currently, organ transplant procedures are insufficient to address the needs of the number of patients that suffer of organ failure related disease. In the United States alone, only around 19% of the patients are able to get an organ transplant surgery and 25% die while waiting for a suitable donor. Tissue engineering (TE) has emerged as an alternative to organ transplant; thus, the aim of the present study was to validate a poly(ethylene glycol) diacrylate (PEG-DA) hydrogel system as a model for material scaffolding in TE applications. This work explores the influence of scaffold material properties on cell behavior. Specifically, scaffold modulus, mesh size, and biochemical stimuli were characterized and their influence on cell response was analyzed at the biochemical, histological and microenvironmental levels. Three different TE targets were evaluated: vocal fold restoration, vascular grafts and osteochondral applications. Vocal fold fibroblast (VFF) phenotype and extracellular matrix (ECM) production were impacted by initial scaffold mesh size and modulus. The results showed increasing levels of SM-?-actin and collagen production with decreasing initial mesh size/increasing initial modulus, which indicated that VFFs were induced to take an undesirable myofibroblast-like phenotype. In addition, it was possible to preserve VFF phenotype in long-term cultured hydrogels containing high molecular weight hyaluronan (HAHMW). On the other hand, regarding vascular graft applications, smooth muscle cell (SMC) phenotype was enhanced by increasing scaffold mesh size and modulus. Finally, the effect of scaffold inorganic content (siloxane) on rat osteoblasts and mouse mesenchymal stem cells was evaluated. Interestingly, the impact of inorganic content on cell differentiation seemed to be highly dependent on the initial cell state. Specifically, mature osteoblasts underwent transdifferentiation into chondrocyte-like cells with increasing inorganic content. However, Mesenchymal stem cells appeared to be preferentially driven toward osteoblast-like cells with an associated increase in osteocalcin and collagen type I production. Advisors/Committee Members: Hahn, Mariah S (advisor), Grunlan, Melissa (committee member), Pishko, Michael (committee member), Ugaz, Victor (committee member).

Subjects/Keywords: Bone tissue engineering; Vascular grafts; Tissue engineering; Hydrogel

…small diameter vascular graft, and bone regeneration. Cell responses were analyzed at the…

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APA (6^th Edition):

Munoz Pinto, D. 1. (2012). Hybrid Polyethylene Glycol Hydrogels for Tissue Engineering Applications. (Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/149213

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Munoz Pinto, Dany 1981-. “Hybrid Polyethylene Glycol Hydrogels for Tissue Engineering Applications.” 2012. Thesis, Texas A&M University. Accessed July 21, 2019. http://hdl.handle.net/1969.1/149213.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Munoz Pinto, Dany 1981-. “Hybrid Polyethylene Glycol Hydrogels for Tissue Engineering Applications.” 2012. Web. 21 Jul 2019.

Vancouver:

Munoz Pinto D1. Hybrid Polyethylene Glycol Hydrogels for Tissue Engineering Applications. [Internet] [Thesis]. Texas A&M University; 2012. [cited 2019 Jul 21]. Available from: http://hdl.handle.net/1969.1/149213.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Munoz Pinto D1. Hybrid Polyethylene Glycol Hydrogels for Tissue Engineering Applications. [Thesis]. Texas A&M University; 2012. Available from: http://hdl.handle.net/1969.1/149213

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

29. Λυκούδης, Ευστάθιος. Η δράση του ανασυνδυασμένου ιστικού ενεργοποιητή του πλασμινογόνου (rt-PA) στη βατότητα και ανάπτυξη ενδοθηλίου μικροχειρουργικών συνθετικ...: πειραματική μελέτη.

Degree: 2000, Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); National and Kapodistrian University of Athens

URL: http://hdl.handle.net/10442/hedi/11857

Subjects/Keywords: Μοσχεύματα; Αγγειακό μόσχευμα; Ινωδόλυση; Θρομβόλυση; Πολυτετραφλουοροαιθυλένιο; Polytetrafluoroethylene; Grafts; Vascular graft

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Λυκούδης, �. (2000). Η δράση του ανασυνδυασμένου ιστικού ενεργοποιητή του πλασμινογόνου (rt-PA) στη βατότητα και ανάπτυξη ενδοθηλίου μικροχειρουργικών συνθετικ...: πειραματική μελέτη. (Thesis). Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); National and Kapodistrian University of Athens. Retrieved from http://hdl.handle.net/10442/hedi/11857

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Λυκούδης, Ευστάθιος. “Η δράση του ανασυνδυασμένου ιστικού ενεργοποιητή του πλασμινογόνου (rt-PA) στη βατότητα και ανάπτυξη ενδοθηλίου μικροχειρουργικών συνθετικ...: πειραματική μελέτη.” 2000. Thesis, Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); National and Kapodistrian University of Athens. Accessed July 21, 2019. http://hdl.handle.net/10442/hedi/11857.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Λυκούδης, Ευστάθιος. “Η δράση του ανασυνδυασμένου ιστικού ενεργοποιητή του πλασμινογόνου (rt-PA) στη βατότητα και ανάπτυξη ενδοθηλίου μικροχειρουργικών συνθετικ...: πειραματική μελέτη.” 2000. Web. 21 Jul 2019.

Vancouver:

Λυκούδης �. Η δράση του ανασυνδυασμένου ιστικού ενεργοποιητή του πλασμινογόνου (rt-PA) στη βατότητα και ανάπτυξη ενδοθηλίου μικροχειρουργικών συνθετικ...: πειραματική μελέτη. [Internet] [Thesis]. Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); National and Kapodistrian University of Athens; 2000. [cited 2019 Jul 21]. Available from: http://hdl.handle.net/10442/hedi/11857.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Λυκούδης �. Η δράση του ανασυνδυασμένου ιστικού ενεργοποιητή του πλασμινογόνου (rt-PA) στη βατότητα και ανάπτυξη ενδοθηλίου μικροχειρουργικών συνθετικ...: πειραματική μελέτη. [Thesis]. Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); National and Kapodistrian University of Athens; 2000. Available from: http://hdl.handle.net/10442/hedi/11857

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

30. Query, Michael Earl. Ultrasound-induced thermal therapy of hyperplasia in ringed expanded polytetrafluoroethylene (ePTFE) access grafts.

Degree: MS, Electrical & Computer Engineering, 2014, University of Utah

URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd3/id/2782/rec/2818

► Hemodialysis vascular access, the interface between a dialysis patient and a dialysis machine, is quite literally the lifeblood of a patient’s health. Vascular access dysfunction… (more)

▼ Hemodialysis vascular access, the interface between a dialysis patient and a dialysis machine, is quite literally the lifeblood of a patient’s health. Vascular access dysfunction is the leading cause of hospitalization in hemodialysis patients. The occlusive growth of neointimal hyperplasia (NH) in expanded polytetrafluoroethylene (ePTFE) ringed grafts is the primary cause of failure. To further develop a proposed thermal ultrasound treatment to reduce or prevent NH in arteriovenous vascular grafts, the acoustic properties of ePTFE were studied in water and alcohol solutions. Previous reports of ePTFE acoustic properties are critiqued. It was found that the acoustic transmission and attenuation through ePTFE, and therefore the potential for an ultrasound-based therapy for NH, are heavily dependent on the medium in which the graft is immersed, suggesting that the acoustic properties of implanted grafts will change as grafts mature in vivo. The acoustic impedance and attenuation of water-soaked ePTFE were 0.478 ± 1.43 × 10-2 MRayl and 1.78 ± 0.111 Np/cm·MHz, respectively, while the acoustic impedance and attenuation of ePTFE in alcohol were 1.49 ± 0.149 MRayl and 0.77 ± 1.1 × 10-2 Np/cm·MHz, respectively.The use of focused ultrasound to heat implanted ringed ePTFE grafts was numerically modeled from 1.35- and 1.443-MHz transducers for in vitro geometries. Power deposition and heating, in turn, differed by an order of magnitude between various graft acoustic properties. Graft rings were predicted to be substantial absorbing andivscattering features.In vitro phantom models were constructed: one with and one without thermocouples. At 1 W of acoustic power, the maximum temperature rise was 8˚ C. The thermocouple model containing a water-soaked graft did not experience heating in the far graft wall. The MRTI model confirmed that the graft rings are an absorbing/scattering feature. Heating was not prevented in the presence of water flow through the graft. Water was not heated significantly. Overall, results suggest ultrasound exposure can be used to generate temperature rises corresponding with the potential prevention or inhibition of NH in ringed ePTFE vascular grafts.A hybrid therapeutic/diagnostic transducer design with a therapeutic semi-annular array surrounding a diagnostic linear array is presented. Compared to a solid transducer of the same dimensions, there were only marginal aberrations in the focal plane. Numerical optimization of the element drive configuration indicated that the least distorted focal plane was produced by uniform phase and magnitude at each element.

Subjects/Keywords: ePTFE; Neointimal hyperplasia; Ultrasonic thermal therapy; Ultrasound; Vascular access grafts

…vascular access: arteriovenous (AV) fistulae, AV grafts, and central venous catheters… …vascular access for hemodialysis patients. 1.2 Problem Statement AV grafts are most commonly… …the bare grafts described in [2] [3]. In many vascular applications… …1. Bare (bottom) and ringed (top) ePTFE vascular grafts. 3 rise in… …parameters of ringed ePTFE vascular grafts; second, numerically simulating and physically measuring…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Query, M. E. (2014). Ultrasound-induced thermal therapy of hyperplasia in ringed expanded polytetrafluoroethylene (ePTFE) access grafts. (Masters Thesis). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd3/id/2782/rec/2818

Chicago Manual of Style (16^th Edition):

Query, Michael Earl. “Ultrasound-induced thermal therapy of hyperplasia in ringed expanded polytetrafluoroethylene (ePTFE) access grafts.” 2014. Masters Thesis, University of Utah. Accessed July 21, 2019. http://content.lib.utah.edu/cdm/singleitem/collection/etd3/id/2782/rec/2818.

MLA Handbook (7^th Edition):

Query, Michael Earl. “Ultrasound-induced thermal therapy of hyperplasia in ringed expanded polytetrafluoroethylene (ePTFE) access grafts.” 2014. Web. 21 Jul 2019.

Vancouver:

Query ME. Ultrasound-induced thermal therapy of hyperplasia in ringed expanded polytetrafluoroethylene (ePTFE) access grafts. [Internet] [Masters thesis]. University of Utah; 2014. [cited 2019 Jul 21]. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd3/id/2782/rec/2818.

Council of Science Editors:

Query ME. Ultrasound-induced thermal therapy of hyperplasia in ringed expanded polytetrafluoroethylene (ePTFE) access grafts. [Masters Thesis]. University of Utah; 2014. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd3/id/2782/rec/2818

Open Access Theses and Dissertations