subject:(Vascular endothelial growth factors)

Rutgers University

1. Mahon, Timothy, 1995-. Polymer-peptide conjugates as mimetics of erythropoietin and vascular endothelial growth factor.

Degree: MS, Biomedical Engineering, 2020, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/62545/

► Many cellular pathways are dependent on receptor activation by proteins which have low stability. Recombinant growth factors and cytokines used to activate these pathways are… (more)

Subjects/Keywords: Erythropoietin; Vascular endothelial growth factors

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APA (6^th Edition):

Mahon, Timothy, 1. (2020). Polymer-peptide conjugates as mimetics of erythropoietin and vascular endothelial growth factor. (Masters Thesis). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/62545/

Chicago Manual of Style (16^th Edition):

Mahon, Timothy, 1995-. “Polymer-peptide conjugates as mimetics of erythropoietin and vascular endothelial growth factor.” 2020. Masters Thesis, Rutgers University. Accessed February 28, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/62545/.

MLA Handbook (7^th Edition):

Mahon, Timothy, 1995-. “Polymer-peptide conjugates as mimetics of erythropoietin and vascular endothelial growth factor.” 2020. Web. 28 Feb 2021.

Vancouver:

Mahon, Timothy 1. Polymer-peptide conjugates as mimetics of erythropoietin and vascular endothelial growth factor. [Internet] [Masters thesis]. Rutgers University; 2020. [cited 2021 Feb 28]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/62545/.

Council of Science Editors:

Mahon, Timothy 1. Polymer-peptide conjugates as mimetics of erythropoietin and vascular endothelial growth factor. [Masters Thesis]. Rutgers University; 2020. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/62545/

Montana State University

2. Dunkel, Haley Ann Arthun. The role of FGF signaling in neural crest development.

Degree: PhD, College of Letters & Science, 2014, Montana State University

URL: https://scholarworks.montana.edu/xmlui/handle/1/9356

► The mechanisms that stimulate Neural Crest Cell (NCC) migration and cessation into discrete sympathetic ganglia (SG) and dorsal root ganglia (DRG) are incompletely understood. In… (more)

▼ The mechanisms that stimulate Neural Crest Cell (NCC) migration and cessation into discrete sympathetic ganglia (SG) and dorsal root ganglia (DRG) are incompletely understood. In this study we investigated the role of Endothelial Cells (ECs) and the shared growth factors of the nervous and vascular system: fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF) in the development of the peripheral nervous system. We hypothesized that ECs impact neural crest patterning. Using live time-lapse microscopy, we found that NCCs and ECs interact extensively during neural crest migration and DRG development, including stimulating proliferation of Pax3+ neural progenitors. These studies also revealed that ECs of the intersomitic vessel perhaps act as a substrate for migrating NCCs while the perisomitic vessel acted as a boundary keeping NCCs in the forming DRG. In order to determine the role of ECs in PNS development we focally eliminated them with FGF receptor (FGFR) blocker Su5402. Su5402 focally reduced ECs and caused NCCs to remain dorsal. Given that FGFs effects could be direct or indirect on NCC, we sought to reduce FGF signaling solely in NCe. To this end we overexpressed a dominant negative FGFRl (DNFGFR1) and FGFR3 in ovo in NCCs. Our studies demonstrated that while blocking FGFR3 signaling did not impair NCC migration, NCCs expressing the DNFGFRl behaved similarly as did the Su4502 treated NCCs: they stayed dorsally at the expense of the SG and DRG and exhibited distinct morphologies. Stimulating FGFR signaling with the ligand FGF8 promoted migration in vitro and increased ventral migration of NCCs in vivo. To determine if the alterations in DNFGFRl + NCCs was due to changes in cell adhesion molecule function, we transfected NCC with DNFGFRl and gain and loss of function Ncadherin constructs. Surprisingly the fate of DNFGFR1+ NCCs was rescued by increasing expression of N-cadherin, while double transfections of DNFGFRl and DN-N-cadherin further impaired migration. While it is possible that N-cadherin and FGFRl directly interact, the exact interactions of FGFRl and N-cadherin need to be further investigated. FGFR3 was not found to function in NCC migration, but preliminary findings show it is required for TrkA+ neural differentiation. Advisors/Committee Members: Chairperson, Graduate Committee: Frances Lefcort (advisor).

Subjects/Keywords: Neural crest.; Endothelial cells.; Fibroblast growth factors.; Vascular endothelial growth factors.; Nerves, Peripheral.

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APA (6^th Edition):

Dunkel, H. A. A. (2014). The role of FGF signaling in neural crest development. (Doctoral Dissertation). Montana State University. Retrieved from https://scholarworks.montana.edu/xmlui/handle/1/9356

Chicago Manual of Style (16^th Edition):

Dunkel, Haley Ann Arthun. “The role of FGF signaling in neural crest development.” 2014. Doctoral Dissertation, Montana State University. Accessed February 28, 2021. https://scholarworks.montana.edu/xmlui/handle/1/9356.

MLA Handbook (7^th Edition):

Dunkel, Haley Ann Arthun. “The role of FGF signaling in neural crest development.” 2014. Web. 28 Feb 2021.

Vancouver:

Dunkel HAA. The role of FGF signaling in neural crest development. [Internet] [Doctoral dissertation]. Montana State University; 2014. [cited 2021 Feb 28]. Available from: https://scholarworks.montana.edu/xmlui/handle/1/9356.

Council of Science Editors:

Dunkel HAA. The role of FGF signaling in neural crest development. [Doctoral Dissertation]. Montana State University; 2014. Available from: https://scholarworks.montana.edu/xmlui/handle/1/9356

Hong Kong University of Science and Technology

3. Hu, Weihui LIFS. Identification of active compounds from Chinese medicine interacting with VEGF by HerboChips : drug development in angiogenic regulation.

Degree: 2019, Hong Kong University of Science and Technology

URL: http://repository.ust.hk/ir/Record/1783.1-105911 ; https://doi.org/10.14711/thesis-991012753260803412 ; http://repository.ust.hk/ir/bitstream/1783.1-105911/1/th_redirect.html

► There is a long history about the usage of traditional Chinese medicine (TCM), and the medicine is renowned in treating diseases. However, the correlations between… (more)

▼ There is a long history about the usage of traditional Chinese medicine (TCM), and the medicine is renowned in treating diseases. However, the correlations between active ingredients and efficacies of TCM are still poorly understood. To identify active compounds from TCM for drug development, a microarray-based drug screening platform, constructed by arraying HPLC fractions of herbal extracts onto a surface-activated polystyrene slide, has been developed. The compounds deriving from individual herbal fractions were chemically coupled to a chip, named as HerboChips®. The phytochemical-coated chip could be applied in drug screening. The biotinylated protein probes, e.g. growth factor, hormone and enzyme, could be used to screen thousands of HerboChips within a short period of time. In view of this application, we aimed to identify effective compounds from TCM that could interact with vascular endothelial growth factor (VEGF) using HerboChips. The biotinylated-VEGF was hybridized with chips coated with different HPLC-separated fractions of herbal extracts. In the screening process, the Straptavidin-Cy5 was used to identify the VEGF-bound fractions. Over 500 TCM chips were screened, and several positive hits were identified, e.g. Ginkgo Folium, Polygoni Cuspidati Rhizoma et Radix, etc. The interaction of identified herbal extracts, or phytochemicals with VEGF, was further confirmed in cultured human umbilical endothelial cells (HUVECs). In HUVECs, the identified TCMs exerted potentiating or inhibitory effects on the VEGF-stimulated cell proliferation, cell migration, cell invasion and tube formation, as well as the VEGF-mediated downstream signallings. By using biacore assay, immunoprecipitation assay and molecular docking, the identified chemicals, i.e. resveratrol and polydatin from Polygoni Cuspidati Rhizoma et Radix, ginkgetin and kaempferol from Ginkgo Folium, were further shown to bind with VEGF markedly. To demonstrate the angiogenic functions of identified compounds, the application of resveratrol, polydatin and ginkgetin suppressed VEGF-induced cell mobilities in cultured HUVECs. These compounds exerted inhibitory effects on the sub-intestinal vessel formation in zebrafish embryos in vivo, as well as microvascular sprouting in rat aortic ring ex vivo. In signalling cascade, the application of resveratrol/polydatin/ginkgetin attenuated VEGF-induced phosphorylations of VEGF receptor 2 and c-Jun N-terminal kinase (JNK), and the VEGF-induced phosphorylations of Akt, eNOS and Erk were significantly decreased after the treatment of these phytochemicals. In contrast, kaempferol potentiated the VEGF-induced cell motility in HUVECs, as well as the formation of sub-intestinal vessel in zebrafish embryos and microvascular sprouting in rat aortic ring. In line to these observations, the potentiation effect of kaempferol was revealed in VEGF-induced migration of skin cell and monocyte. By auto-docking analysis, ginkgetin and resveratrol showed different binding sites to VEGF. The synergy of ginkgetin and resveratrol in…

Subjects/Keywords: Medicine, Chinese ; Analysis ; Herbs ; Therapeutic use ; Vascular endothelial growth factors

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APA (6^th Edition):

Hu, W. L. (2019). Identification of active compounds from Chinese medicine interacting with VEGF by HerboChips : drug development in angiogenic regulation. (Thesis). Hong Kong University of Science and Technology. Retrieved from http://repository.ust.hk/ir/Record/1783.1-105911 ; https://doi.org/10.14711/thesis-991012753260803412 ; http://repository.ust.hk/ir/bitstream/1783.1-105911/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hu, Weihui LIFS. “Identification of active compounds from Chinese medicine interacting with VEGF by HerboChips : drug development in angiogenic regulation.” 2019. Thesis, Hong Kong University of Science and Technology. Accessed February 28, 2021. http://repository.ust.hk/ir/Record/1783.1-105911 ; https://doi.org/10.14711/thesis-991012753260803412 ; http://repository.ust.hk/ir/bitstream/1783.1-105911/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hu, Weihui LIFS. “Identification of active compounds from Chinese medicine interacting with VEGF by HerboChips : drug development in angiogenic regulation.” 2019. Web. 28 Feb 2021.

Vancouver:

Hu WL. Identification of active compounds from Chinese medicine interacting with VEGF by HerboChips : drug development in angiogenic regulation. [Internet] [Thesis]. Hong Kong University of Science and Technology; 2019. [cited 2021 Feb 28]. Available from: http://repository.ust.hk/ir/Record/1783.1-105911 ; https://doi.org/10.14711/thesis-991012753260803412 ; http://repository.ust.hk/ir/bitstream/1783.1-105911/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hu WL. Identification of active compounds from Chinese medicine interacting with VEGF by HerboChips : drug development in angiogenic regulation. [Thesis]. Hong Kong University of Science and Technology; 2019. Available from: http://repository.ust.hk/ir/Record/1783.1-105911 ; https://doi.org/10.14711/thesis-991012753260803412 ; http://repository.ust.hk/ir/bitstream/1783.1-105911/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Columbia University

4. Pfister, Neil Thomas. Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to mediate VEGFR2 expression in breast cancer cells.

Degree: 2015, Columbia University

URL: https://doi.org/10.7916/D8H130R1

► Mutant p53 impacts the expression of numerous genes at the level of transcription to mediate oncogenesis. To investigate how mutant p53 impacts transcription, we studied… (more)

▼ Mutant p53 impacts the expression of numerous genes at the level of transcription to mediate oncogenesis. To investigate how mutant p53 impacts transcription, we studied how mutant p53 regulates vascular endothelial growth factor receptor 2 (VEGFR2), one of its strongest target genes that we identified through global gene expression profiling in mutant p53 expressing MDA 468 breast cancer cells. VEGFR2, the primary functional VEGF receptor and clinical target of bevacizumab, mediates endothelial cell neovascularization by promoting increased cellular proliferation, migration, and pro-survival signaling. In breast tumors, VEGFR2 is often aberrantly expressed on the breast tumor epithelia,which correlates with worse overall survival. We identify VEGFR2 as a mutant p53 transcriptional target in multiple breast cancer cell lines. Mutant p53 mediated upregulation of VEGFR2 mediates mutant 53 gain of function including increased cellular growth and migration. In humans, breast tumors with TP53 hotspot mutants have elevated VEGFR2 levels compared to tumors with loss of function mutations. The same class of tumors has significantly upregulated HIF1A and VEGFA compared to TP53 wild type tumors, indicating that mutant p53 containing breast tumors express a neoangiogenic gene signature that may intensify VEGFR2 autocrine signaling. A clinical trial suggests that TP53 mutated breast tumors may specifically respond to anti VEGF therapy, while TP53 wild type tumors may not respond. We suggest that mutant p53 containing breast tumors may be distinctively vulnerable to anti VEGF ntherapies. We investigated how mutant p53 impacts transcription of VEGFR2 using multiple techniques including scanning ChIP, micrococcal nuclease PCR, and in vivo DNase I footprinting by ligation mediated PCR. Mutant p53 was found to bind near the VEGFR2 transcriptional start site, causing the promoter to adopt a transcriptionally active conformation. Using SILAC mass spectrometry, we identified subunits of the SWI/SNF chromatin remodeling complex as mutant p53 interactors. Importantly, re ChIP and immunodepletion ChIP demonstrate that mutant p53 and SWI/SNF co-occupy the VEGFR2 promoter. Depletion of multiple SWI/SNF subunits reduced VEGFR2 RNA expression, and SWI/SNF is required for maximal mutant p53 promoter occupancy. Using RNA sequencing, we report that approximately half of all mutant p53 gene alteration impacts transcription of VEGFR2 as well as myriad other target genes by promoter remodeling through interaction with the SWI/SNF chromatin remodeling complex. Therefore, not only might mutant p53 expressing tumors be uniquely susceptible to anti VEGF therapies, but restoration of SWI/SNF tumor suppressor function by targeting mutant p53 may have therapeutic potential. Mutant p53 interaction with the SWI/SNF complex may explain how mutant p53 modulates the expression of such a diverse set of genes.

Subjects/Keywords: Vascular endothelial growth factors; Transcription factors; Mutation (Biology); Oncology; Molecular biology; Medicine

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APA (6^th Edition):

Pfister, N. T. (2015). Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to mediate VEGFR2 expression in breast cancer cells. (Doctoral Dissertation). Columbia University. Retrieved from https://doi.org/10.7916/D8H130R1

Chicago Manual of Style (16^th Edition):

Pfister, Neil Thomas. “Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to mediate VEGFR2 expression in breast cancer cells.” 2015. Doctoral Dissertation, Columbia University. Accessed February 28, 2021. https://doi.org/10.7916/D8H130R1.

MLA Handbook (7^th Edition):

Pfister, Neil Thomas. “Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to mediate VEGFR2 expression in breast cancer cells.” 2015. Web. 28 Feb 2021.

Vancouver:

Pfister NT. Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to mediate VEGFR2 expression in breast cancer cells. [Internet] [Doctoral dissertation]. Columbia University; 2015. [cited 2021 Feb 28]. Available from: https://doi.org/10.7916/D8H130R1.

Council of Science Editors:

Pfister NT. Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to mediate VEGFR2 expression in breast cancer cells. [Doctoral Dissertation]. Columbia University; 2015. Available from: https://doi.org/10.7916/D8H130R1

Stellenbosch University

5. Marincowitz, Clara Maria Elizabeth. The Effects of HIV-1-proteins and Antiretroviral Therapy on Aortic Endothelial Cells (AECs) – A Mechanistic in vitro Approach.

Degree: MSc, Biomedical Sciences, 2019, Stellenbosch University

URL: http://hdl.handle.net/10019.1/105871

► Introduction: Endothelial dysfunction is an early precursor of cardiovascular disease characterized by decreased nitric oxide (NO) levels following the development of oxidative stress. Oxidative stress… (more)

▼ Introduction: Endothelial dysfunction is an early precursor of cardiovascular disease characterized by decreased nitric oxide (NO) levels following the development of oxidative stress. Oxidative stress has been shown to result not only in the inactivation of NO itself, but also of endothelial NO synthase (eNOS), the enzyme responsible for NO synthesis. This contributes to creating a pro-inflammatory environment in the vasculature, which can lead to atherosclerosis and cardiovascular disease. Increased endothelial dysfunction and cardiovascular risk have been observed in both HIV-1 infection and antiretroviral therapy (ART). Objectives: To establish a simulated model of in vitro HIV-1-infection and determine the effects of non/nucleoside reverse transcriptase inhibitors (NRTI/NNRTIs) and protease inhibitors (PIs) on markers of endothelial function and the expression/activation of important vascular signalling proteins within this HIV-1-model. Methods: A simulated HIV-1-model was established by adding recombinant HIV-1 proteins (100 ng/ml each of Nef, Tat and Gp160) to the growth medium of cultured rat aortic endothelial cells (AECs). Subsequently, the effects of NRTI/NNRTIs (efavirenz, emtricitabine and tenofovir) and PIs (lopinavir and ritonavir) on these HIV-1 exposed AECs were determined using fluorescent probes to assess cell viability, NO-production and oxidative stress via reactive nitrogen species (RNS) production. The expression/activation of important vascular signalling proteins, including eNOS and IκBα (an inhibitor of the inflammatory NFκB signalling pathway), was also evaluated by western blotting. Results: Exposure to 100 ng/ml of HIV-1 Nef, Tat and Gp160 for 24 hours led to a significant decrease in NO production in AECs (DAF-2/DA fluorescence intensity: 72.05±8.37% vs. 100±1.55%). NRTI/NNRTI treatment within an HIV-1-protein medium environment for 24 hours had no effect on NO production, possibly abrogating the reduced levels observed with HIV-1-protein treatment on its own. Furthermore, a decrease in RNS was observed (DHR-123 fluorescence intensity: 83.19±3.5% vs. 100±0.22%). PI treatment within an HIV-1-protein medium environment for 24 hours resulted in a reduction in NO production in a concentration-dependent manner (DAF-2/DA fluorescence intensity: 92.74±1.4% vs. 100±0.67% and 85±1.81% vs. 100±0.56%), probably due to decreased eNOS expression (0.28±0.04 vs. 1±0.21). Interestingly, neither HIV-1 protein exposure on its own, nor PI treatment in isolation had any effects on eNOS. The same was observed for IκBα, where combined HIV-1-protein and PI exposure reduced levels (0.37±0.03 vs. 1±0.15) and neither of these treatments in isolation had any effects. Conclusion: HIV-1 Nef, Tat and Gp160 attenuated NO production in AECs, while NRTI/NNRTI treatment within this HIV-1 protein environment showed minimal adverse effects, and could possibly even be beneficial, potentially reversing the detrimental consequences of HIV-1 proteins on NO production. PI treatment, on the other hand, seemed to demonstrate… Advisors/Committee Members: Genis, Amanda, Strijdom, Hans, Stellenbosch University. Faculty of Medicine and Health Science. Dept. of Biomedical Sciences: Medical Physiology..

Subjects/Keywords: Vascular endothelial growth factors; Antiretroviral agents; Endothelial Nitric Oxide Synthase; HIV-proteins; Human Immunodeficiency Virus; Nitric Oxide; UCTD

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APA (6^th Edition):

Marincowitz, C. M. E. (2019). The Effects of HIV-1-proteins and Antiretroviral Therapy on Aortic Endothelial Cells (AECs) – A Mechanistic in vitro Approach. (Masters Thesis). Stellenbosch University. Retrieved from http://hdl.handle.net/10019.1/105871

Chicago Manual of Style (16^th Edition):

Marincowitz, Clara Maria Elizabeth. “The Effects of HIV-1-proteins and Antiretroviral Therapy on Aortic Endothelial Cells (AECs) – A Mechanistic in vitro Approach.” 2019. Masters Thesis, Stellenbosch University. Accessed February 28, 2021. http://hdl.handle.net/10019.1/105871.

MLA Handbook (7^th Edition):

Marincowitz, Clara Maria Elizabeth. “The Effects of HIV-1-proteins and Antiretroviral Therapy on Aortic Endothelial Cells (AECs) – A Mechanistic in vitro Approach.” 2019. Web. 28 Feb 2021.

Vancouver:

Marincowitz CME. The Effects of HIV-1-proteins and Antiretroviral Therapy on Aortic Endothelial Cells (AECs) – A Mechanistic in vitro Approach. [Internet] [Masters thesis]. Stellenbosch University; 2019. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10019.1/105871.

Council of Science Editors:

Marincowitz CME. The Effects of HIV-1-proteins and Antiretroviral Therapy on Aortic Endothelial Cells (AECs) – A Mechanistic in vitro Approach. [Masters Thesis]. Stellenbosch University; 2019. Available from: http://hdl.handle.net/10019.1/105871

Penn State University

6. Subramanian, Anita. THE EFFECT OF PRENATAL VITAMIN D SUPPLEMENTATION ON MATERNAL BLOOD PRESSURE AND PLACENTAL ANGIOGENESIS IN BANGLADESH.

Degree: 2019, Penn State University

URL: https://submit-etda.libraries.psu.edu/catalog/17151afs5465

► min D deficiency has become a problem of public health concern with high prevalence rates among pregnant women especially in South Asia. Maternal vitamin D… (more)

▼ min D deficiency has become a problem of public health concern with high prevalence rates among pregnant women especially in South Asia. Maternal vitamin D deficiency during pregnancy has been associated with adverse maternal and birth outcomes such as increased risk of preeclampsia and fetal growth restriction. Although vitamin D has been associated with hypertensive disorders of pregnancy, the effect of vitamin D on blood pressure trajectory across pregnancy is unclear. The placenta functions in the metabolism of vitamin D during pregnancy and is related to growth and development of the fetus, but limited understanding exists on the role of vitamin D in placental angiogenesis. Further, there is some evidence to show that angiogenic factors released from the placenta into the maternal circulation may impact maternal vasculature. However, few studies have examined both placental angiogenic factors and maternal blood pressure in humans. The overall goal of this dissertation was to examine the effect of prenatal vitamin D supplementation on maternal blood pressure and placental angiogenesis within the context of a large randomized controlled trial in Bangladesh. The studies in this dissertation are nested within the Maternal Vitamin D for Infant Growth (MDIG) trial, a randomized, placebo-controlled, dose-ranging trial of vitamin D supplementation in Dhaka, Bangladesh (n=1298). Participants were individually randomized to one of four vitamin D doses during the prenatal period: placebo, 4200 IU/week, 16800 IU/wk or 28000 IU/wk. The MDIG trial enrolled healthy pregnant women at 17-24 weeks that had a singleton gestation and did not have preexisting hypertension or other health conditions. The first aim was to examine the dose-dependent effect of prenatal vitamin D supplementation on maternal blood pressure from mid to late pregnancy. Blood pressure was measured at enrollment, 24 weeks, and 30 weeks, and weekly from 36 weeks until delivery. This sub-study examined 1257 women with at least 2 blood pressure measurements prior to the onset of labor. The prevalence of vitamin D deficiency (25-hydroxyvitamin D [25(OH)D] <30 nmol/L) at enrollment was 64%. Vitamin D treatment did not have an effect on SBP or DBP at 24 or 30 weeks gestation; blood pressure was higher at 36 weeks gestation for the highest dose of vitamin D compared to placebo (mean difference (95% CI): SBP (mm Hg) = 2.32 (0.91, 3.72); DBP (mm Hg) = 1.86 (0.71, 3.00)), adjusting for baseline blood pressure and gestational age at enrollment. The differences in changes of SBP and DBP between vitamin D groups and placebo across intervals were all small (p values >0.10), but the difference for 28000 IU/wk vs. placebo was the highest from 30 to 36 weeks (SBP 0.2 (-0.1, 0.5) and DBP 0.19 (-0.0, 0.4) mm Hg) and lowest from 36 weeks to delivery (SBP -0.3 (-0.9, 0.3) mm Hg; DBP 0.1 (-0.6, 0.4). The second aim was to examine the dose-dependent effect of prenatal vitamin D supplementation on placental angiogenesis. We examined expression of two key angiogenic factors in… Advisors/Committee Members: Alison Diane Gernand, Dissertation Advisor/Co-Advisor, Alison Diane Gernand, Committee Chair/Co-Chair, Xiang Gao, Committee Member, Runze Li, Committee Member, Francisco Javier Diaz, Outside Member, Daniel E. Roth, Special Member, Laura E Murray-Kolb, Program Head/Chair.

Subjects/Keywords: Pregnancy; Vascular Endothelial Growth Factor; Placental Growth Factor; Angiogenic Factors; Vitamin D; Placental Villi; Systolic Blood Pressure; Diastolic Blood Pressure

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APA (6^th Edition):

Subramanian, A. (2019). THE EFFECT OF PRENATAL VITAMIN D SUPPLEMENTATION ON MATERNAL BLOOD PRESSURE AND PLACENTAL ANGIOGENESIS IN BANGLADESH. (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/17151afs5465

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Subramanian, Anita. “THE EFFECT OF PRENATAL VITAMIN D SUPPLEMENTATION ON MATERNAL BLOOD PRESSURE AND PLACENTAL ANGIOGENESIS IN BANGLADESH.” 2019. Thesis, Penn State University. Accessed February 28, 2021. https://submit-etda.libraries.psu.edu/catalog/17151afs5465.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Subramanian, Anita. “THE EFFECT OF PRENATAL VITAMIN D SUPPLEMENTATION ON MATERNAL BLOOD PRESSURE AND PLACENTAL ANGIOGENESIS IN BANGLADESH.” 2019. Web. 28 Feb 2021.

Vancouver:

Subramanian A. THE EFFECT OF PRENATAL VITAMIN D SUPPLEMENTATION ON MATERNAL BLOOD PRESSURE AND PLACENTAL ANGIOGENESIS IN BANGLADESH. [Internet] [Thesis]. Penn State University; 2019. [cited 2021 Feb 28]. Available from: https://submit-etda.libraries.psu.edu/catalog/17151afs5465.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Subramanian A. THE EFFECT OF PRENATAL VITAMIN D SUPPLEMENTATION ON MATERNAL BLOOD PRESSURE AND PLACENTAL ANGIOGENESIS IN BANGLADESH. [Thesis]. Penn State University; 2019. Available from: https://submit-etda.libraries.psu.edu/catalog/17151afs5465

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Pretoria

7. Mukorera, Varaidzo. Expression of vascular endothelial growth factor in dogs with Spirocerca lupi-associated neoplastic transformation .

Degree: 2012, University of Pretoria

URL: http://upetd.up.ac.za/thesis/available/etd-11222012-151159/

► Tumour development is dependent upon the formation of an adequate blood supply through angiogenesis. Vascular endothelial growth factor (VEGF) is one of the most potent… (more)

▼ Tumour development is dependent upon the formation of an adequate blood supply through angiogenesis. Vascular endothelial growth factor (VEGF) is one of the most potent and specific pro-angiogenic factors associated with tumour development. Vascular endothelial growth factor is elevated in dogs with a variety of neoplastic tumours and has been linked to an increased risk for metastasis and a poorer prognosis in several tumours. Spirocerca lupi (S. lupi) is a nematode of canids which infests the oesophagus where it forms a nodule. The oesophageal nodule can develop into a neoplastic tumour namely osteosarcoma, fibrosarcoma or anaplastic sarcoma. The pathogenesis of the neoplastic transformation is poorly understood. Diagnosis of neoplastic transformation can be challenging and is based on endoscopy-guided biopsies which are invasive, expensive and may yield non diagnostic samples. The aim of this prospective study was to determine if serum and plasma VEGF levels could be used to distinguish between neoplastic and non-neoplastic spirocercosis. Twenty four dogs were enrolled in the study, 9 with non-neoplastic, 9 with neoplastic spirocercosis, and 6 control dogs. Plasma and serum samples for VEGF analysis were collected at diagnosis. Measurement of VEGF was done using a canine VEGF Quantikine ELISA kit. Statistical analysis to compare the means of the VEGF concentrations between the groups was performed using the Kruskal-Wallis followed by the Dunn’s test. Significance was set at p<0.05 The median plasma VEGF concentration of the dogs with neoplastic spirocercosis 629pg/ml (range 282 – 2366) was higher than the median plasma VEGF concentrations of both the non-neoplastic 0pg/ml (range 0 – 716) and controls 0pg/ml (range 0 – 0) (p<0.001). The median serum VEGF concentration of the neoplastic dogs 69pg/ml (range 0 – 212) was higher than the serum VEGF concentrations in the non-neoplastic 0pg/ml (range 0 – 44.13) and control 0pg/ml (range 0 – 39.4) (p=0.001). Plasma VEGF at a cut off value of 250pg/ml was determined to have a sensitivity of 100%, specificity of 77.8%, a PPV of 81.8% and a NPV of 100% for determining neoplastic transformation. Serum VEGF at a cut off value of 25pg/ml was determined to have a sensitivity of 88.9%, specificity of 100%, a PPV of 100% and a NPV of 90% for determining neoplastic transformation. Both plasma and serum VEGF concentrations can be used to differentiate between non-neoplastic and neoplastic spirocercosis. Plasma VEGF concentrations were higher than serum VEGF concentrations, contrary to what is reported in literature. Both plasma and serum VEGF concentrations can, therefore, potentially be used for diagnosis of neoplastic vs. non-neoplastic cases in canine spirocercosis. There is a need to perform more studies to determine cut-off concentrations that would maximize the sensitivity and specificity for determining neoplastic transformation in canine spirocercosis as well as to determine the role of VEGF in the pathogenesis of the neoplastic transformation. Copyright Advisors/Committee Members: Prof E Dvir (advisor).

Subjects/Keywords: Vascular endothelial growth factor; Dogs; UCTD

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mukorera, V. (2012). Expression of vascular endothelial growth factor in dogs with Spirocerca lupi-associated neoplastic transformation . (Masters Thesis). University of Pretoria. Retrieved from http://upetd.up.ac.za/thesis/available/etd-11222012-151159/

Chicago Manual of Style (16^th Edition):

Mukorera, Varaidzo. “Expression of vascular endothelial growth factor in dogs with Spirocerca lupi-associated neoplastic transformation .” 2012. Masters Thesis, University of Pretoria. Accessed February 28, 2021. http://upetd.up.ac.za/thesis/available/etd-11222012-151159/.

MLA Handbook (7^th Edition):

Mukorera, Varaidzo. “Expression of vascular endothelial growth factor in dogs with Spirocerca lupi-associated neoplastic transformation .” 2012. Web. 28 Feb 2021.

Vancouver:

Mukorera V. Expression of vascular endothelial growth factor in dogs with Spirocerca lupi-associated neoplastic transformation . [Internet] [Masters thesis]. University of Pretoria; 2012. [cited 2021 Feb 28]. Available from: http://upetd.up.ac.za/thesis/available/etd-11222012-151159/.

Council of Science Editors:

Mukorera V. Expression of vascular endothelial growth factor in dogs with Spirocerca lupi-associated neoplastic transformation . [Masters Thesis]. University of Pretoria; 2012. Available from: http://upetd.up.ac.za/thesis/available/etd-11222012-151159/

University of Pretoria

8. Mukorera, Varaidzo. Expression of vascular endothelial growth factor in dogs with Spirocerca lupi-associated neoplastic transformation.

Degree: Companion Animal Clinical Studies, 2012, University of Pretoria

URL: http://hdl.handle.net/2263/29710

► Tumour development is dependent upon the formation of an adequate blood supply through angiogenesis. Vascular endothelial growth factor (VEGF) is one of the most potent… (more)

▼ Tumour development is dependent upon the formation of an adequate blood supply through angiogenesis. Vascular endothelial growth factor (VEGF) is one of the most potent and specific pro-angiogenic factors associated with tumour development. Vascular endothelial growth factor is elevated in dogs with a variety of neoplastic tumours and has been linked to an increased risk for metastasis and a poorer prognosis in several tumours. Spirocerca lupi (S. lupi) is a nematode of canids which infests the oesophagus where it forms a nodule. The oesophageal nodule can develop into a neoplastic tumour namely osteosarcoma, fibrosarcoma or anaplastic sarcoma. The pathogenesis of the neoplastic transformation is poorly understood. Diagnosis of neoplastic transformation can be challenging and is based on endoscopy-guided biopsies which are invasive, expensive and may yield non diagnostic samples. The aim of this prospective study was to determine if serum and plasma VEGF levels could be used to distinguish between neoplastic and non-neoplastic spirocercosis. Twenty four dogs were enrolled in the study, 9 with non-neoplastic, 9 with neoplastic spirocercosis, and 6 control dogs. Plasma and serum samples for VEGF analysis were collected at diagnosis. Measurement of VEGF was done using a canine VEGF Quantikine ELISA kit. Statistical analysis to compare the means of the VEGF concentrations between the groups was performed using the Kruskal-Wallis followed by the Dunn’s test. Significance was set at p<0.05 The median plasma VEGF concentration of the dogs with neoplastic spirocercosis 629pg/ml (range 282 – 2366) was higher than the median plasma VEGF concentrations of both the non-neoplastic 0pg/ml (range 0 – 716) and controls 0pg/ml (range 0 – 0) (p<0.001). The median serum VEGF concentration of the neoplastic dogs 69pg/ml (range 0 – 212) was higher than the serum VEGF concentrations in the non-neoplastic 0pg/ml (range 0 – 44.13) and control 0pg/ml (range 0 – 39.4) (p=0.001). Plasma VEGF at a cut off value of 250pg/ml was determined to have a sensitivity of 100%, specificity of 77.8%, a PPV of 81.8% and a NPV of 100% for determining neoplastic transformation. Serum VEGF at a cut off value of 25pg/ml was determined to have a sensitivity of 88.9%, specificity of 100%, a PPV of 100% and a NPV of 90% for determining neoplastic transformation. Both plasma and serum VEGF concentrations can be used to differentiate between non-neoplastic and neoplastic spirocercosis. Plasma VEGF concentrations were higher than serum VEGF concentrations, contrary to what is reported in literature. Both plasma and serum VEGF concentrations can, therefore, potentially be used for diagnosis of neoplastic vs. non-neoplastic cases in canine spirocercosis. There is a need to perform more studies to determine cut-off concentrations that would maximize the sensitivity and specificity for determining neoplastic transformation in canine spirocercosis as well as to determine the role of VEGF in the pathogenesis of the neoplastic transformation. Copyright Advisors/Committee Members: Prof E Dvir (advisor).

Subjects/Keywords: Vascular endothelial growth factor; Dogs; UCTD

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mukorera, V. (2012). Expression of vascular endothelial growth factor in dogs with Spirocerca lupi-associated neoplastic transformation. (Masters Thesis). University of Pretoria. Retrieved from http://hdl.handle.net/2263/29710

Chicago Manual of Style (16^th Edition):

Mukorera, Varaidzo. “Expression of vascular endothelial growth factor in dogs with Spirocerca lupi-associated neoplastic transformation.” 2012. Masters Thesis, University of Pretoria. Accessed February 28, 2021. http://hdl.handle.net/2263/29710.

MLA Handbook (7^th Edition):

Mukorera, Varaidzo. “Expression of vascular endothelial growth factor in dogs with Spirocerca lupi-associated neoplastic transformation.” 2012. Web. 28 Feb 2021.

Vancouver:

Mukorera V. Expression of vascular endothelial growth factor in dogs with Spirocerca lupi-associated neoplastic transformation. [Internet] [Masters thesis]. University of Pretoria; 2012. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/2263/29710.

Council of Science Editors:

Mukorera V. Expression of vascular endothelial growth factor in dogs with Spirocerca lupi-associated neoplastic transformation. [Masters Thesis]. University of Pretoria; 2012. Available from: http://hdl.handle.net/2263/29710

9. Costa, Rafaela Alkmin da. Dosagem seriada dos fatores reguladores de angiogênese soluble fms-like tyrosine kinase-1 (sFlt-1) e placental growth factor (PIGF) para predição de pré-eclâmpsia e pré-eclâmpsia superajuntada.

Degree: PhD, Obstetrícia e Ginecologia, 2014, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/5/5139/tde-12012015-144329/ ;

► Apesar de sua importância clínica e epidemiológica, a fisiopatologia da préeclâmpsia ainda não foi completamente compreendida. Sabe-se que a doença constitui-se de uma fase pré-clínica… (more)

▼ Apesar de sua importância clínica e epidemiológica, a fisiopatologia da préeclâmpsia ainda não foi completamente compreendida. Sabe-se que a doença constitui-se de uma fase pré-clínica e um estágio clínico. Durante a última década muito esforço tem se concentrado na identificação precoce da doença, ainda em sua fase pré-clínica. A literatura científica tem demonstrado claramente um desequilíbrio na regulação da angiogênese das gestantes com pré-eclâmpsia, marcado por níveis elevados do fator antiangiogênico soluble fms-like tyrosine kinase-1 (sFlt-1) e níveis diminuídos do fator pró-angiogênico placental growth fator (PlGF). Embora um número crescente de estudos em populações de alto risco tenha avaliado o papel desses biomarcadores no diagnóstico de pré-eclâmpsia, dados sobre sua utilização para a predição de pré-eclâmpsia superajuntada, cujo diagnóstico pode ser particularmente difícil, permanecem relativamente escassos e controversos. Com o presente estudo pretendemos avaliar o desempenho de medidas seriadas dos níveis maternos circulantes dos fatores sFlt-1 e PlGF, bem como da razão sFlt-1/PlGF, para predição de pré-eclâmpsia superajuntada e compará-lo ao seu desempenho na predição de pré-eclâmpsia em sua forma \"pura\", não superajuntada. Para este propósito, estudamos uma coorte prospectiva composta de dois braços, um de gestantes com hipertensão arterial crônica e outro de gestantes normotensas, e avaliamos os níveis séricos de sFlt-1 e de PlGF e a razão sFlt-1/PlGF nas idades gestacionais de 20, 26, 32 e 36 semanas, tendo como desfecho principal o diagnóstico de pré-eclâmpsia. Um total de 97 gestantes foram acompanhadas, 37 normotensas e 60 com hipertensão arterial crônica. Entre elas, 4 (10,8%) desenvolveram pré-eclâmpsia e 14 (23,3%) desenvolveram pré-eclâmpsia superajuntada. Para predição de pré-eclâmpsia, a análise ROC (Receiver Operating Characteristics) apresentou área sob a curva (AUC - area under curve) de 0,83 (IC 95% = 0,68-0,99, P = 0,035) para dosagem de PlGF com 20 semanas e AUC = 0,92 (IC 95% = 0,81 - 1,00, P = 0,007) para a razão sFlt-1/PlGF com 26 semanas de gestação. A variação percentual dos níveis de PlGF entre 26 e 32 semanas de gestação apresentou AUC = 0,96 (IC de 95% = 0,89-1,00, P = 0,003). Para a predição de pré-eclâmpsia superajuntada, a razão sFlt-1/PIGF na idade gestacional de 32 semanas apresentou AUC = 0,69 (IC de 95% = 0,53-0,85, P = 0,039). Entre 20 e 26 semanas de gestação, a variação percentual do PIGF e da razão sFlt-1/PlGF apresentaram, respectivamente, AUC = 0,74 (IC de 95% = 0,58-0,90, P = 0,018) e AUC = 0,71 (IC 95% = 0,52-0,91, P = 0,034). Por nossos resultados podemos concluir que, embora os níveis de PlGF e a razão sFlt-1/ PlGF tenham apresentado bons desempenhos na predição de pré-eclâmpsia, é preciso ter cuidado ao usá-los para a predição de pré-eclâmpsia superajuntada. Nessas gestantes, a dosagem dos fatores angiogênicos apresenta capacidade de predição menor e mais tardia. Avaliações seriadas dos fatores podem melhorar o desempenho dos testes para predição de… Advisors/Committee Members: Francisco, Rossana Pulcineli Vieira.

Subjects/Keywords: Angiogenic proteins; Fatores de crescimento do endotélio vascular; Pre-eclampsia; Préeclâmpsia; Proteínas angiogênicas; Receptor 1 dos fatores de crescimento do endotélio vascular; Vascular endothelial growth factor receptor-1; Vascular endothelial growth factors

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Costa, R. A. d. (2014). Dosagem seriada dos fatores reguladores de angiogênese soluble fms-like tyrosine kinase-1 (sFlt-1) e placental growth factor (PIGF) para predição de pré-eclâmpsia e pré-eclâmpsia superajuntada. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/5/5139/tde-12012015-144329/ ;

Chicago Manual of Style (16^th Edition):

Costa, Rafaela Alkmin da. “Dosagem seriada dos fatores reguladores de angiogênese soluble fms-like tyrosine kinase-1 (sFlt-1) e placental growth factor (PIGF) para predição de pré-eclâmpsia e pré-eclâmpsia superajuntada.” 2014. Doctoral Dissertation, University of São Paulo. Accessed February 28, 2021. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-12012015-144329/ ;.

MLA Handbook (7^th Edition):

Costa, Rafaela Alkmin da. “Dosagem seriada dos fatores reguladores de angiogênese soluble fms-like tyrosine kinase-1 (sFlt-1) e placental growth factor (PIGF) para predição de pré-eclâmpsia e pré-eclâmpsia superajuntada.” 2014. Web. 28 Feb 2021.

Vancouver:

Costa RAd. Dosagem seriada dos fatores reguladores de angiogênese soluble fms-like tyrosine kinase-1 (sFlt-1) e placental growth factor (PIGF) para predição de pré-eclâmpsia e pré-eclâmpsia superajuntada. [Internet] [Doctoral dissertation]. University of São Paulo; 2014. [cited 2021 Feb 28]. Available from: http://www.teses.usp.br/teses/disponiveis/5/5139/tde-12012015-144329/ ;.

Council of Science Editors:

Costa RAd. Dosagem seriada dos fatores reguladores de angiogênese soluble fms-like tyrosine kinase-1 (sFlt-1) e placental growth factor (PIGF) para predição de pré-eclâmpsia e pré-eclâmpsia superajuntada. [Doctoral Dissertation]. University of São Paulo; 2014. Available from: http://www.teses.usp.br/teses/disponiveis/5/5139/tde-12012015-144329/ ;

University of Hong Kong

10. Makkar, Guneet. Role of cytokines in reduced implantation following excessive ovarian stimulation.

Degree: 2005, University of Hong Kong

URL: http://hdl.handle.net/10722/52242

Subjects/Keywords: Ovulation - Induction.; Vascular endothelial growth factors.; Steroid hormones.; Cytokines.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Makkar, G. (2005). Role of cytokines in reduced implantation following excessive ovarian stimulation. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/52242

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Makkar, Guneet. “Role of cytokines in reduced implantation following excessive ovarian stimulation.” 2005. Thesis, University of Hong Kong. Accessed February 28, 2021. http://hdl.handle.net/10722/52242.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Makkar, Guneet. “Role of cytokines in reduced implantation following excessive ovarian stimulation.” 2005. Web. 28 Feb 2021.

Vancouver:

Makkar G. Role of cytokines in reduced implantation following excessive ovarian stimulation. [Internet] [Thesis]. University of Hong Kong; 2005. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10722/52242.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Makkar G. Role of cytokines in reduced implantation following excessive ovarian stimulation. [Thesis]. University of Hong Kong; 2005. Available from: http://hdl.handle.net/10722/52242

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Hong Kong

11. Poon, Tung-ping, Ronnie. Prognostic significance of circulating vascular endothlial [sic] growth factor in patients with hepatocellular carcinoma.

Degree: 2006, University of Hong Kong

URL: http://hdl.handle.net/10722/52770

Subjects/Keywords: Vascular endothelial growth factors; Liver - Cancer - Prognosis.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Poon, T. (2006). Prognostic significance of circulating vascular endothlial [sic] growth factor in patients with hepatocellular carcinoma. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/52770

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Poon, Tung-ping,. “Prognostic significance of circulating vascular endothlial [sic] growth factor in patients with hepatocellular carcinoma.” 2006. Thesis, University of Hong Kong. Accessed February 28, 2021. http://hdl.handle.net/10722/52770.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Poon, Tung-ping,. “Prognostic significance of circulating vascular endothlial [sic] growth factor in patients with hepatocellular carcinoma.” 2006. Web. 28 Feb 2021.

Vancouver:

Poon T. Prognostic significance of circulating vascular endothlial [sic] growth factor in patients with hepatocellular carcinoma. [Internet] [Thesis]. University of Hong Kong; 2006. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10722/52770.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Poon T. Prognostic significance of circulating vascular endothlial [sic] growth factor in patients with hepatocellular carcinoma. [Thesis]. University of Hong Kong; 2006. Available from: http://hdl.handle.net/10722/52770

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Hong Kong

12. Ng, Hoi-man. Regulation of vascular endothelial growth factor by ginsenoside RG1 inhuman endothelial cells.

Degree: 2009, University of Hong Kong

URL: http://hdl.handle.net/10722/61045

Subjects/Keywords: Ginseng - Therapeutic use.; Vascular endothelial growth factors.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ng, H. (2009). Regulation of vascular endothelial growth factor by ginsenoside RG1 inhuman endothelial cells. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/61045

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ng, Hoi-man. “Regulation of vascular endothelial growth factor by ginsenoside RG1 inhuman endothelial cells.” 2009. Thesis, University of Hong Kong. Accessed February 28, 2021. http://hdl.handle.net/10722/61045.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ng, Hoi-man. “Regulation of vascular endothelial growth factor by ginsenoside RG1 inhuman endothelial cells.” 2009. Web. 28 Feb 2021.

Vancouver:

Ng H. Regulation of vascular endothelial growth factor by ginsenoside RG1 inhuman endothelial cells. [Internet] [Thesis]. University of Hong Kong; 2009. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10722/61045.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ng H. Regulation of vascular endothelial growth factor by ginsenoside RG1 inhuman endothelial cells. [Thesis]. University of Hong Kong; 2009. Available from: http://hdl.handle.net/10722/61045

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade Nova

13. Rodrigues, Maria Inês Moreira Patrício. New roles of Rab GTPases on eye diseases: targeting VEGF secretion.

Degree: 2012, Universidade Nova

URL: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/10533

► RESUMO: A retina é composta, entre outras estruturas, pelo epitélio pigmentar da retina (EPR)e pela coróide. A região central da retina denomina-se mácula, e é… (more)

▼ RESUMO: A retina é composta, entre outras estruturas, pelo epitélio pigmentar da retina (EPR)e pela coróide. A região central da retina denomina-se mácula, e é a zona mais afetada na degenerescência macular relacionada com a idade, a forma mais comum de degenerescência da retina. Nesta doença, a secreção de fatores de crescimento pelo EPR é afetada, nomeadamente a do fator de crescimento vascular endotelial (VEGF), e pouco se sabe ainda sobre os mecanismos moleculares conducentes a esta condição. A família de proteínas Rab GTPases está envolvida nas vias intracelulares de sinalização e tráfego membranares, essenciais na transdução de sinais extracelulares em respostas biológicas. A sua crucial importância nestes mecanismos levou-nos a considerar o seu potencial envolvimento nas vias de secreção do VEGF, e a questionar-nos se teriam algum papel regulador sobre as mesmas. O principal objetivo deste trabalho é identificar Rab GTPases importantes para as vias de secreção e endocitose do VEGF no EPR. Essa identificação ajudará a esclarecer a patogénese da degenerescência macular da retina, e poderá servir para uma procura mais direcionada de novos agentes terapêuticos. A caracterização de dois modelos in vitro do EPR, células primárias isoladas de murganho e a linha celular B6-RPE07,levou-nos a concluir que são ambos semelhantes. Contudo, a linha celular foi escolhida como protótipo do EPR por permitir o acesso a um número ilimitado de células. No decurso deste trabalho, desenvolvemos e caracterizámos uma biblioteca de ferramentas moleculares que nos permitiram reduzir os níveis proteicos das proteínas Rab GTPases, com base na tecnologia de ácido ribonucleico (ARN) de interferência. O papel das proteínas Rab GTPases na secreção do VEGF no EPR foi estudado com base no silenciamento de apenas uma proteína, ou combinando várias, segundo a sua localização e funções intracelulares descritas. Este trabalho permitiu-nos concluir que as proteínas Rab GTPases são importantes intervenientes no processo de secreção de VEGF pelo EPR, e confirmar dados anteriores que relatam o envolvimento de algumas Rab GTPases endocíticas no processo. Propomos ainda um novo modelo para a interação destas proteínas no EPR, e sugerimos que a Rab10 e a Rab14 atuam negativamente sobre a Rab8, controlando o seu funcionamento. Os nossos resultados evidenciam a importância das proteínas Rab GTPases na secreção do VEGF pelas células do EPR, e servem de base a futuros estudos que melhor procurem compreender este mecanismo e de que modo a sua alteração se relaciona com a degenerescência da retina. – – – ABSTRACT: Retinal pigment epithelium (RPE) and choroid are components of the mammalian retina, of which the central region is called macula. The most common form of retinaldegeneration, age-related macular degeneration (AMD), involves primarily deregulation of growth factors secretion by the RPE. Very little is known about the molecular mechanisms that lead to impairment of RPE’s homeostatic intracellular processes, namely the secretion of vascular…

Subjects/Keywords: Eye Diseases; Vascular Endothelial Growth Factors - therapeutic use; GTP Phosphohydrolases - metabolism; Tumor Suppressor Proteins; Biologia Celular

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rodrigues, M. I. M. P. (2012). New roles of Rab GTPases on eye diseases: targeting VEGF secretion. (Thesis). Universidade Nova. Retrieved from http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/10533

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rodrigues, Maria Inês Moreira Patrício. “New roles of Rab GTPases on eye diseases: targeting VEGF secretion.” 2012. Thesis, Universidade Nova. Accessed February 28, 2021. http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/10533.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rodrigues, Maria Inês Moreira Patrício. “New roles of Rab GTPases on eye diseases: targeting VEGF secretion.” 2012. Web. 28 Feb 2021.

Vancouver:

Rodrigues MIMP. New roles of Rab GTPases on eye diseases: targeting VEGF secretion. [Internet] [Thesis]. Universidade Nova; 2012. [cited 2021 Feb 28]. Available from: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/10533.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rodrigues MIMP. New roles of Rab GTPases on eye diseases: targeting VEGF secretion. [Thesis]. Universidade Nova; 2012. Available from: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/10533

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Missouri – Columbia

14. Chen, Jing, 1962-. Mechanism of induction of vascular endothelial growth factor (vegf) in osteoarthritis.

Degree: 2006, University of Missouri – Columbia

URL: https://doi.org/10.32469/10355/4616

► Vascular endothelial growth factor (VEGF) is an endothelial cell mitogen and an angiogenic factor. Angiogenesis regulated by VEGF is a critical event in the pathogenesis… (more)

Subjects/Keywords: Vascular endothelial growth factors; Osteoarthritis – Pathogenesis; Genetic regulation; Metalloproteinases

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APA (6^th Edition):

Chen, Jing, 1. (2006). Mechanism of induction of vascular endothelial growth factor (vegf) in osteoarthritis. (Thesis). University of Missouri – Columbia. Retrieved from https://doi.org/10.32469/10355/4616

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chen, Jing, 1962-. “Mechanism of induction of vascular endothelial growth factor (vegf) in osteoarthritis.” 2006. Thesis, University of Missouri – Columbia. Accessed February 28, 2021. https://doi.org/10.32469/10355/4616.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chen, Jing, 1962-. “Mechanism of induction of vascular endothelial growth factor (vegf) in osteoarthritis.” 2006. Web. 28 Feb 2021.

Vancouver:

Chen, Jing 1. Mechanism of induction of vascular endothelial growth factor (vegf) in osteoarthritis. [Internet] [Thesis]. University of Missouri – Columbia; 2006. [cited 2021 Feb 28]. Available from: https://doi.org/10.32469/10355/4616.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chen, Jing 1. Mechanism of induction of vascular endothelial growth factor (vegf) in osteoarthritis. [Thesis]. University of Missouri – Columbia; 2006. Available from: https://doi.org/10.32469/10355/4616

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Sul

15. Zart, Ronald Paulo Pinto. Identificação da expressão do vascular endothelial growth factor (VEGF) pela contagem de células marcadas imunoistoquimicamente no omento de ratos após ligadura arterial e após ligadura venosa.

Degree: 2007, Universidade do Rio Grande do Sul

URL: http://hdl.handle.net/10183/11516

►

O sistema cardiovascular está estrutural e funcionalmente disposto de modo “circular”. Situações de obstrução do fluxo sanguíneo determinam o aparecimento de mecanismos que visam suplantar… (more)

▼

O sistema cardiovascular está estrutural e funcionalmente disposto de modo “circular”. Situações de obstrução do fluxo sanguíneo determinam o aparecimento de mecanismos que visam suplantar tais interrupções e manter a circularidade íntegra. À nível molecular, o principal elemento envolvido nestes mecanismos é o Vascular Endothelial Growth Factor (VEGF). A expressão do VEGF quando há oclusão arterial está bem documentada, faltando elementos com relação à oclusão venosa. Neste estudo objetivamos verificar se a oclusão à nível arterial determina uma expressão do VEGF diferente daquela que ocorre se a oclusão acontecer à nível venoso. Para isso randomizamos dois grupos de ratos de experimentação. Em um grupo realizamos a oclusão da aorta infra-renal e em outro a oclusão da veia cava infra-renal. Posteriormente medimos a expressão do VEGF através da contagem do número de células marcadas imunoistoquimicamente no omento destes ratos. O resultado demonstrou que a expressão do VEGF, quando analisada pelo método proposto foi igual no grupo da oclusão venosa e no grupo da oclusão arterial.

The cardiovascular system is structurally and functionally circular. Situations in which there is obstruction to blood flow trigger mechanisms to bypass these blockages and maintenance the integrity of the circularity. At the molecular level the main factor involved is the Vascular Endothelial Growth Factor (VEGF). The VEGF expression associated with arterial occlusion is well documented but is lacking evidence when venous occlusion occurs. This study aimed to verify if the expression of VEGF when an occlusion occurs at venous level is the same or different from that caused at the arterial level. Two groups of rats were randomized by infra-renal aortic occlusion or inferior vena cava occlusion. VEGF was measured by counting the immunohistochemistry method marked cells at the omentum level. It was demonstrated that the VEGF expression is the same in the venous group obstruction as the arterial obstruction group.

Advisors/Committee Members: Saadi, Eduardo Keller.

Subjects/Keywords: Doença das coronárias; Circulatory system; Growth factors; Vascular endothelial growth factor; Arterial occlusion; Venous occlusion; Angiogenesis; Arteriogenesis; Venogenesis; Collateral circulation; Immunohistochemistry; Vascular density; Cellular densit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zart, R. P. P. (2007). Identificação da expressão do vascular endothelial growth factor (VEGF) pela contagem de células marcadas imunoistoquimicamente no omento de ratos após ligadura arterial e após ligadura venosa. (Thesis). Universidade do Rio Grande do Sul. Retrieved from http://hdl.handle.net/10183/11516

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Zart, Ronald Paulo Pinto. “Identificação da expressão do vascular endothelial growth factor (VEGF) pela contagem de células marcadas imunoistoquimicamente no omento de ratos após ligadura arterial e após ligadura venosa.” 2007. Thesis, Universidade do Rio Grande do Sul. Accessed February 28, 2021. http://hdl.handle.net/10183/11516.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Zart, Ronald Paulo Pinto. “Identificação da expressão do vascular endothelial growth factor (VEGF) pela contagem de células marcadas imunoistoquimicamente no omento de ratos após ligadura arterial e após ligadura venosa.” 2007. Web. 28 Feb 2021.

Vancouver:

Zart RPP. Identificação da expressão do vascular endothelial growth factor (VEGF) pela contagem de células marcadas imunoistoquimicamente no omento de ratos após ligadura arterial e após ligadura venosa. [Internet] [Thesis]. Universidade do Rio Grande do Sul; 2007. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10183/11516.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Zart RPP. Identificação da expressão do vascular endothelial growth factor (VEGF) pela contagem de células marcadas imunoistoquimicamente no omento de ratos após ligadura arterial e após ligadura venosa. [Thesis]. Universidade do Rio Grande do Sul; 2007. Available from: http://hdl.handle.net/10183/11516

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Manchester

16. Khalid, Mahmood Waseem Khalid. Vascular stability and maintenance in first trimester placental explants: An experimental study.

Degree: 2014, University of Manchester

URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:218029

► The human placenta is a highly vascularised organ which is responsible for the outgrowth and wellbeing of the growing foetus. Understanding the vascular development of… (more)

Subjects/Keywords: Vascular system maintenance; Vascular endothelial growth factor; Placental growth factor; First trimester placenta; Vascular structure

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APA (6^th Edition):

Khalid, M. W. K. (2014). Vascular stability and maintenance in first trimester placental explants: An experimental study. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:218029

Chicago Manual of Style (16^th Edition):

Khalid, Mahmood Waseem Khalid. “Vascular stability and maintenance in first trimester placental explants: An experimental study.” 2014. Doctoral Dissertation, University of Manchester. Accessed February 28, 2021. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:218029.

MLA Handbook (7^th Edition):

Khalid, Mahmood Waseem Khalid. “Vascular stability and maintenance in first trimester placental explants: An experimental study.” 2014. Web. 28 Feb 2021.

Vancouver:

Khalid MWK. Vascular stability and maintenance in first trimester placental explants: An experimental study. [Internet] [Doctoral dissertation]. University of Manchester; 2014. [cited 2021 Feb 28]. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:218029.

Council of Science Editors:

Khalid MWK. Vascular stability and maintenance in first trimester placental explants: An experimental study. [Doctoral Dissertation]. University of Manchester; 2014. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:218029

Freie Universität Berlin

17. Parotat, Anna. Effective cultivation of canine Schwann cells using VEGF and FGF-2 for reconstruction of peripheral nerve lesions.

Degree: 2010, Freie Universität Berlin

URL: https://refubium.fu-berlin.de/handle/fub188/12308

► Current surgical techniques to restore normal peripheral nerve function remain unsatisfying in veterinary as well as in human medicine, indicating a need for new treatment… (more)

▼ Current surgical techniques to restore normal peripheral nerve function remain unsatisfying in veterinary as well as in human medicine, indicating a need for new treatment strategies. Schwann cell coated tubular implants present one promising option. The development of such artificial grafts for the dog requires the isolation and in vitro expansion of pure canine Schwann cell cultures. The study aimed to establish an effective method for isolation, purification and expansion of canine Schwann cell cultures. The research results produced a guideline for such isolation, purification and expansion with the help of VEGF and FGF-2. Nerve biopsies from nine dogs of different ages were extracted from the N. radialis and N. ischiadicus directly after euthanasia. The biopsy length was about four cm. Nerves were prepared under sterile conditions and cut into pieces of one to two mm. Comparing serum added DMEM+ and serumfree MM+ as media for cultivation, serum added DMEM+ is recommended in this stage. The explants were passaged weekly and dissociated after 21 days with a digestion medium containing hyaluronidase (0.1%), collagenase (0.1%), DNase (0.1%) and trypsin. Mixed cell cultures were obtained after dissociation. Pure cultures of canine Schwann cells were gained by repeated short trypsination and incubation in MM+. Schwann cells in vitro and in situ were identified by immunolabeling with an established antibody to p75-NTR, which marks Schwann cells but not fibroblasts. The proliferative effect of VEGF and FGF-2 was examined in the purified and cryoconserved Schwann cell cultures. All experiments were done six-fold and repeated three times. Quantitative analyses of the proliferative effect were done using two different detection systems, the BrdU assay and the Resazurin-Resorufin assay. First the proliferative effect of VEGF and FGF-2 was tested separately in the concentrations of 5 ng/ml, 10 ng/ml, 50 ng/ml and 100 ng/ml, and compared to DMEM+ without growth factors (the negative control). Despite high variabilities of the absolute cell counts, an increase in arithmetic mean of the logarithmic cell count (lgCC) with increasing concentrations of VEGF and FGF-2 up to 50 ng/ml was detected in both proliferation assays and in all passages, for both growth factors. An enhancement in growth factor concentration of up to 100 ng/ml did not lead to higher amounts of Schwann cells. Concentrations of 50 ng/ml in both VEGF and FGF-2 contained the strongest proliferative effect on canine Schwann cells. Furthermore, incubation of canine Schwann cells in 50 ng/ml FGF-2 resulted in a significantly higher cell count compared to incubation in 50 ng/ml of VEGF. Therefore, cultivation of canine Schwann cells in 50 ng/ml FGF-2 recommends itself. Separate Schwann cells in 50 ng/ml FGF-2 concentrations of 5 ng/ml lead to a significantly higher lgCC in only one of the cases compared to the negative control group. Due to this effect, the growth factor concentrations of 10 ng/ml, 50 ng/ml and 100 ng/ml in DMEM+ were combined in each possible… Advisors/Committee Members: w (gender), Univ.-Prof. Dr. Johanna Plendl (firstReferee), Univ.-Prof. Dr. Leo Brunnberg (furtherReferee), Univ.-Prof. Dr. Angelika Richter (furtherReferee).

Subjects/Keywords: dogs; nervous system; regeneration; cultivation; growth factors; vascular endothelial growth factor a [MeSH]; fibroblast growth; 600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Parotat, A. (2010). Effective cultivation of canine Schwann cells using VEGF and FGF-2 for reconstruction of peripheral nerve lesions. (Thesis). Freie Universität Berlin. Retrieved from https://refubium.fu-berlin.de/handle/fub188/12308

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Parotat, Anna. “Effective cultivation of canine Schwann cells using VEGF and FGF-2 for reconstruction of peripheral nerve lesions.” 2010. Thesis, Freie Universität Berlin. Accessed February 28, 2021. https://refubium.fu-berlin.de/handle/fub188/12308.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Parotat, Anna. “Effective cultivation of canine Schwann cells using VEGF and FGF-2 for reconstruction of peripheral nerve lesions.” 2010. Web. 28 Feb 2021.

Vancouver:

Parotat A. Effective cultivation of canine Schwann cells using VEGF and FGF-2 for reconstruction of peripheral nerve lesions. [Internet] [Thesis]. Freie Universität Berlin; 2010. [cited 2021 Feb 28]. Available from: https://refubium.fu-berlin.de/handle/fub188/12308.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Parotat A. Effective cultivation of canine Schwann cells using VEGF and FGF-2 for reconstruction of peripheral nerve lesions. [Thesis]. Freie Universität Berlin; 2010. Available from: https://refubium.fu-berlin.de/handle/fub188/12308

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Bristol

18. Harris, Rachel E. VEGFR1 and VEGFR2 in dementia.

Degree: PhD, 2019, University of Bristol

URL: https://research-information.bris.ac.uk/en/studentTheses/46d762c2-8677-4b67-b430-62ea6f19c94f ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.782617

► Brain ischaemia is the defining pathological process in vascular dementia (VaD); however, cerebral blood flow is also reduced in Alzheimer's disease (AD) and there is… (more)

Subjects/Keywords: Vascular endothelial growth factor; VEGF; Alzheimer's disease; Vascular dementia; VEGFR1; VEGFR2

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APA (6^th Edition):

Harris, R. E. (2019). VEGFR1 and VEGFR2 in dementia. (Doctoral Dissertation). University of Bristol. Retrieved from https://research-information.bris.ac.uk/en/studentTheses/46d762c2-8677-4b67-b430-62ea6f19c94f ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.782617

Chicago Manual of Style (16^th Edition):

Harris, Rachel E. “VEGFR1 and VEGFR2 in dementia.” 2019. Doctoral Dissertation, University of Bristol. Accessed February 28, 2021. https://research-information.bris.ac.uk/en/studentTheses/46d762c2-8677-4b67-b430-62ea6f19c94f ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.782617.

MLA Handbook (7^th Edition):

Harris, Rachel E. “VEGFR1 and VEGFR2 in dementia.” 2019. Web. 28 Feb 2021.

Vancouver:

Harris RE. VEGFR1 and VEGFR2 in dementia. [Internet] [Doctoral dissertation]. University of Bristol; 2019. [cited 2021 Feb 28]. Available from: https://research-information.bris.ac.uk/en/studentTheses/46d762c2-8677-4b67-b430-62ea6f19c94f ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.782617.

Council of Science Editors:

Harris RE. VEGFR1 and VEGFR2 in dementia. [Doctoral Dissertation]. University of Bristol; 2019. Available from: https://research-information.bris.ac.uk/en/studentTheses/46d762c2-8677-4b67-b430-62ea6f19c94f ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.782617

University of Hong Kong

19. 戴娟. Recombinant adeno-associated virus mediated vascular endothelial growth factor gene therapy induces mandibular condylar growth.

Degree: 2007, University of Hong Kong

URL: http://hdl.handle.net/10722/50913

Subjects/Keywords: Vascular endothelial growth factors.; Mandibular condyle - Growth.; Adenoviruses.; Gene therapy.

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APA (6^th Edition):

戴娟.. (2007). Recombinant adeno-associated virus mediated vascular endothelial growth factor gene therapy induces mandibular condylar growth. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/50913

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

戴娟.. “Recombinant adeno-associated virus mediated vascular endothelial growth factor gene therapy induces mandibular condylar growth.” 2007. Thesis, University of Hong Kong. Accessed February 28, 2021. http://hdl.handle.net/10722/50913.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

戴娟.. “Recombinant adeno-associated virus mediated vascular endothelial growth factor gene therapy induces mandibular condylar growth.” 2007. Web. 28 Feb 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

戴娟.. Recombinant adeno-associated virus mediated vascular endothelial growth factor gene therapy induces mandibular condylar growth. [Internet] [Thesis]. University of Hong Kong; 2007. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10722/50913.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

戴娟.. Recombinant adeno-associated virus mediated vascular endothelial growth factor gene therapy induces mandibular condylar growth. [Thesis]. University of Hong Kong; 2007. Available from: http://hdl.handle.net/10722/50913

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

20. Cargill, Robert S. Regulation of VEGF by TEAD4 and HIF-1[alpha] in murine oxygen-induced retinopathy.

Degree: PhD, 2013, Oregon Health Sciences University

URL: doi:10.6083/M4TQ5ZKM ; http://digitalcommons.ohsu.edu/etd/930

Subjects/Keywords: Vascular endothelial growth factors; Retina – Diseases; Anoxemia; Transcription factors; Vascular Endothelial Growth Factors; Retinal Diseases; Anoxia; Transcription Factors; Hypoxia-Inducible Factor 1

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APA (6^th Edition):

Cargill, R. S. (2013). Regulation of VEGF by TEAD4 and HIF-1[alpha] in murine oxygen-induced retinopathy. (Doctoral Dissertation). Oregon Health Sciences University. Retrieved from doi:10.6083/M4TQ5ZKM ; http://digitalcommons.ohsu.edu/etd/930

Chicago Manual of Style (16^th Edition):

Cargill, Robert S. “Regulation of VEGF by TEAD4 and HIF-1[alpha] in murine oxygen-induced retinopathy.” 2013. Doctoral Dissertation, Oregon Health Sciences University. Accessed February 28, 2021. doi:10.6083/M4TQ5ZKM ; http://digitalcommons.ohsu.edu/etd/930.

MLA Handbook (7^th Edition):

Cargill, Robert S. “Regulation of VEGF by TEAD4 and HIF-1[alpha] in murine oxygen-induced retinopathy.” 2013. Web. 28 Feb 2021.

Vancouver:

Cargill RS. Regulation of VEGF by TEAD4 and HIF-1[alpha] in murine oxygen-induced retinopathy. [Internet] [Doctoral dissertation]. Oregon Health Sciences University; 2013. [cited 2021 Feb 28]. Available from: doi:10.6083/M4TQ5ZKM ; http://digitalcommons.ohsu.edu/etd/930.

Council of Science Editors:

Cargill RS. Regulation of VEGF by TEAD4 and HIF-1[alpha] in murine oxygen-induced retinopathy. [Doctoral Dissertation]. Oregon Health Sciences University; 2013. Available from: doi:10.6083/M4TQ5ZKM ; http://digitalcommons.ohsu.edu/etd/930

Loma Linda University

21. Ajao, David Olufemi. Caveolins and NJKs Influence Brain Endothelial Permeability after Juvenile TBI.

Degree: PhD, Basic Sciences, 2013, Loma Linda University

URL: https://scholarsrepository.llu.edu/etd/217

► Disruption of blood-brain barrier (BBB) is a key secondary event that exacerbates brain damage following traumatic brain injury (TBI). BBB disruption is particularly damaging… (more)

▼ Disruption of blood-brain barrier (BBB) is a key secondary event that exacerbates brain damage following traumatic brain injury (TBI). BBB disruption is particularly damaging to the developing brain – which is highly vulnerable to various stress stimuli, resulting in increased brain swelling, disrupted cerebral blood flow (CBF) autoregulation, long-term disabilities and death following TBI in young demographic. Unsurprisingly, BBB disruption and the resultant cerebral edema have emerged as therapeutic targets in juvenile TBI. It is therefore important to understand the molecular players and mechanisms involved in TBI-induced BBB disruption in the juvenile brain. To this end, the endothelial caveolins and c-Jun N-terminal kinases (JNKs) were identified as proteins of interest in the regulation of brain endothelial permeability after injury. These were investigated under a three-fold aim. The first was to characterize the acute and long-term histological and functional changes occurring following injury to the developing brain. Second was the attempt to profile the changes in expression patterns of caveolins after juvenile TBI in conjunction with BBB disruption. And lastly, the effects of molecular agents that target JNK (DJNKI-1) and caveolin (cavtratin) pathways respectively were examined on BBB integrity, and on imaging, histological and functional outcomes. To achieve these aims, an experimental model of TBI in juvenile rats was developed and characterized. Evidence emerged that long-term white matter dysfunction occurs in this model, in parallel with delayed neurodevelopment and persistence of behavioral deficits, which mimics data from clinical and longitudinal TBI observations. There was both acute and long-term increase in the expression level of caveolin-1 in the endothelium and reactive astrocytes following juvenile TBI. Furthermore, acute administration of cavtratin, a peptide mimetic of caveolin-1 scaffolding domain, markedly reduced edema formation and lesion volume without improving sensorimotor outcome in the acute time points. However, competitive inhibition of the JNK pathway with acute administration of DJNKI-1 markedly ameliorates BBB permeability, reduced edema formation, and improves neuroimaging and neurological outcomes at both acute and chronic time points. These findings could potentially be exploited for future therapeutic applications in juvenile brain trauma. Advisors/Committee Members: Pearce, William J., Badaut, Jerome, Hirt, Lorenz, Obenaus, Andre, Zhang, John H..

Subjects/Keywords: Medical Neurobiology; Medical Physiology; Neurology; Physiology; Brain Injuries - Physiopathology; Brain Edema; Brain - Growth & Development; Endothelium - Vascular; Vascular Endothelial Growth Factors; Vesicular Transport Proteins; Caveolins; JNK Mitogen-Activated Protein Kinases; Blood-Brain Barrier; Cerebral Brain Flow; Juvenile Brains; Brain Endothelial Permeability; Traumatic Brain Injury; TBI; BBB

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ajao, D. O. (2013). Caveolins and NJKs Influence Brain Endothelial Permeability after Juvenile TBI. (Doctoral Dissertation). Loma Linda University. Retrieved from https://scholarsrepository.llu.edu/etd/217

Chicago Manual of Style (16^th Edition):

Ajao, David Olufemi. “Caveolins and NJKs Influence Brain Endothelial Permeability after Juvenile TBI.” 2013. Doctoral Dissertation, Loma Linda University. Accessed February 28, 2021. https://scholarsrepository.llu.edu/etd/217.

MLA Handbook (7^th Edition):

Ajao, David Olufemi. “Caveolins and NJKs Influence Brain Endothelial Permeability after Juvenile TBI.” 2013. Web. 28 Feb 2021.

Vancouver:

Ajao DO. Caveolins and NJKs Influence Brain Endothelial Permeability after Juvenile TBI. [Internet] [Doctoral dissertation]. Loma Linda University; 2013. [cited 2021 Feb 28]. Available from: https://scholarsrepository.llu.edu/etd/217.

Council of Science Editors:

Ajao DO. Caveolins and NJKs Influence Brain Endothelial Permeability after Juvenile TBI. [Doctoral Dissertation]. Loma Linda University; 2013. Available from: https://scholarsrepository.llu.edu/etd/217

Univerzitet u Beogradu

22. Skorobać Ašanin, Violeta, 1970-. Analiza preživljavanja autolognih adipocita u rekonstruktivnoj i plastičnoj hirurgiji.

Degree: Medicinski fakultet, 2018, Univerzitet u Beogradu

URL: https://fedorabg.bg.ac.rs/fedora/get/o:17454/bdef:Content/get

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Medicina - Plastična, rekonstruktivna i estetska hirurgija / Medicine - Plastic, reconstructive and aesthetic surgery

Uvod. Savremeno doba je obeležilo razvoj tehnika uzimanja i transplantacije… (more)

▼

Medicina - Plastična, rekonstruktivna i estetska hirurgija / Medicine - Plastic, reconstructive and aesthetic surgery

Uvod. Savremeno doba je obeležilo razvoj tehnika uzimanja i transplantacije autolognog masnog tkiva u svrhu rekonstrukcija meko-tkivnih defekata sa jedne strane, a sa druge strane javila se potreba za istraživanjem njegovih regenerativnih potencijala. Masno tkivo kao jedan od najvećih endokrinih organa u ljudskom organizmu, reguliše brojne metaboličke procese, ne samo masti već i drugih endokrinih sistema. U njegovim sekretornim aktivnostima učestvuju, naizgled, jednostavna masna ćelija i njegov ćelijski bogat ekstracelularni matriks. Povećana zainteresovanost brojnih istraživača se pojavila nakon izdvajanja mezenhimnih matičnih ćelija iz frakcije vaskularne strome masnog tkiva. Međutim, obezbediti sigurno preživljavanje autolognog masnog tkiva je veliki zadatak savremenih istraživača. Sam proces preživljavanja adipocita ili diferencijacija progenitorskih ćelija adipocita u druge ćeliske linije i dalje je kontraverzno pitanje. Prednost korišćenja masnog tkiva je u njegovoj dostupnosti u većim količinama, potencijalno lakoj implementaciji u pojedine delove tela, biološke kompatibilnosti, niskog antigenog potencijala i minimalnog donorskog morbiditeta. Ciljevi istraživanja. Naš cilj je bio da ispitamo preoperativne i postoperativne morfološke i volumetrijske karakteristike transplantiranog masnog tkiva recipijentnog tkiva potkolenice magnetnom rezonancom. U cilju utvrđivanja morfoloških i funkcionalnih ćeliskih promena radili smo histološka i imunohistohemijaska ispitivanja masnog tkiva subkutano aspirirane masti iz donorskog i recipijentnog regiona. Materijal i metod. Studija je obuhvatila 67 ispitanika ženskog pola starosti između 20 i 58 godina sa hipoplazijom potkolenice Tip III - posteriorna hipoplazija sa slabo razvijenim m.gastrocnemis-om i m. soleus-om. Ispitanike smo, pre operacije i jedan, tri i šest meseci posle operacije, fotografisali i antropološki merili: telesnu masu, indeks telesne mase, obime pojedinih delova potkolenica. Takođe, pre operativno i šest meseci postoperativno smo radili magnetnu rezonancu potkolenica radi utvrđivanja morfološke različitosti u recipijentnom regionu. U toku operacije uzimali smo uzorke različito pripremljenih transplantanata masti iz donorskog regiona, koji su histološki i imunohistohemijski ispitivani. Isti postupak uzorkovanja masti iz recipijentnog regiona radili smo šest meseci nakon operacije...

Advisors/Committee Members: Sopta, Jelena, 1971-.

Subjects/Keywords: lower leg augmentation; fat transplantation; MRI; fat tissue survival; fat reabsorption; stromal vascular fraction; growth factors; vascular endothelial growth factor VEGF; epidermal growth factor EFG; thrombocytes growth factor PDGF; mesenchyme cells; lipo-filling

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Skorobać Ašanin, Violeta, 1. (2018). Analiza preživljavanja autolognih adipocita u rekonstruktivnoj i plastičnoj hirurgiji. (Thesis). Univerzitet u Beogradu. Retrieved from https://fedorabg.bg.ac.rs/fedora/get/o:17454/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Skorobać Ašanin, Violeta, 1970-. “Analiza preživljavanja autolognih adipocita u rekonstruktivnoj i plastičnoj hirurgiji.” 2018. Thesis, Univerzitet u Beogradu. Accessed February 28, 2021. https://fedorabg.bg.ac.rs/fedora/get/o:17454/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Skorobać Ašanin, Violeta, 1970-. “Analiza preživljavanja autolognih adipocita u rekonstruktivnoj i plastičnoj hirurgiji.” 2018. Web. 28 Feb 2021.

Vancouver:

Skorobać Ašanin, Violeta 1. Analiza preživljavanja autolognih adipocita u rekonstruktivnoj i plastičnoj hirurgiji. [Internet] [Thesis]. Univerzitet u Beogradu; 2018. [cited 2021 Feb 28]. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:17454/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Skorobać Ašanin, Violeta 1. Analiza preživljavanja autolognih adipocita u rekonstruktivnoj i plastičnoj hirurgiji. [Thesis]. Univerzitet u Beogradu; 2018. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:17454/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Queensland University of Technology

23. Gillies, Peter John. Modulation of dermal microvascular endithelial cell responses to growth factors and haemostatic factors in the presence of vitronectin.

Degree: 2008, Queensland University of Technology

URL: https://eprints.qut.edu.au/37176/

► In order to effect permanent closure in burns patients suffering from full thickness wounds, replacing their skin via split thickness autografting, is essential. Dermal substitutes… (more)

▼ In order to effect permanent closure in burns patients suffering from full thickness wounds, replacing their skin via split thickness autografting, is essential. Dermal substitutes in conjunction with widely meshed split thickness autografts (+/- cultured keratinocytes) reduce scarring at the donor and recipient sites of burns patients by reducing demand for autologous skin (both surface area and thickness), without compromising dermal delivery at the wound face. Tissue engineered products such as Integra consist of a dermal template which is rapidly remodelled to form a neodermis, at which time the temporary silicone outer layer is removed and replaced with autologous split thickness skin. Whilst provision of a thick tissue engineered dermis at full thickness burn sites reduces scarring, it is hampered by delays in vascularisation which results in clinical failure. The ultimate success of any skin graft product is dependent upon a number of basic factors including adherence, haemostasis and in the case of viable tissue grafts, success is ultimately dependent upon restoration of a normal blood supply, and hence this study. Ultimately, the goal of this research is to improve the therapeutic properties of tissue replacements, through impregnation with growth factors aimed at stimulating migration and proliferation of microvascular endothelial cells into the donor tissue post grafting. For the purpose of my masters, the aim was to evaluate the responsiveness of a dermal microvascular endothelial cell line to growth factors and haemostatic factors, in the presence of the glycoprotein vitronectin. Vitronectin formed the backbone for my hypothesis and research due to its association with both epithelial and, more specifically, endothelial migration and proliferation. Early work using a platform technology referred to as VitroGro (Tissue Therapies Ltd), which is comprised of vitronectin bound BP5/IGF-1, aided keratinocyte proliferation. I hypothesised that this result would translate to another epithelium - endothelium. VitroGro had no effect on endothelial proliferation or migration. Vitronectin increases the presence of Fibroblast Growth Factor (FGF) and Vascular Endothelial Growth Factor (VEGF) receptors, enhancing cell responsiveness to their respective ligands. So, although Human Microvascular Endothelial Cell line 1 (HMEC-1) VEGF receptor expression is generally low, it was hypothesised that exposure to vitronectin would up-regulate this receptor. HMEC-1 migration, but not proliferation, was enhanced by vitronectin bound VEGF, as well as vitronectin bound Epidermal Growth Factor (EGF), both of which could be used to stimulate microvascular endothelial cell migration for the purpose of transplantation. In addition to vitronectin's synergy with various growth factors, it has also been shown to play a role in haemostasis. Vitronectin binds thrombin-antithrombin III (TAT) to form a trimeric complex that takes on many of the attributes of vitronectin, such as heparin affinity, which results in its adherence to endothelium…

Subjects/Keywords: Growth factors; Skin grafting; Burns and scalds Treatment; Vitronectin; burns; skin grafting; angiogenesis; dermal microvascular endithelial cells; HMEC-1; growth factors; insulin-like growth factors; insulin-like growth factor binding proteins; epidermal growth factor; fibroblast growth factor; placenta growth factor; vascular endothelial growth factor; vitronectin; thrombin; antithrombin III; cell proliferation; cell migration; thesis; masters

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gillies, P. J. (2008). Modulation of dermal microvascular endithelial cell responses to growth factors and haemostatic factors in the presence of vitronectin. (Thesis). Queensland University of Technology. Retrieved from https://eprints.qut.edu.au/37176/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gillies, Peter John. “Modulation of dermal microvascular endithelial cell responses to growth factors and haemostatic factors in the presence of vitronectin.” 2008. Thesis, Queensland University of Technology. Accessed February 28, 2021. https://eprints.qut.edu.au/37176/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gillies, Peter John. “Modulation of dermal microvascular endithelial cell responses to growth factors and haemostatic factors in the presence of vitronectin.” 2008. Web. 28 Feb 2021.

Vancouver:

Gillies PJ. Modulation of dermal microvascular endithelial cell responses to growth factors and haemostatic factors in the presence of vitronectin. [Internet] [Thesis]. Queensland University of Technology; 2008. [cited 2021 Feb 28]. Available from: https://eprints.qut.edu.au/37176/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gillies PJ. Modulation of dermal microvascular endithelial cell responses to growth factors and haemostatic factors in the presence of vitronectin. [Thesis]. Queensland University of Technology; 2008. Available from: https://eprints.qut.edu.au/37176/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Kentucky

24. Li, Xiaobo. PHYSICAL INTERACTIONS BETWEEN NEUROPILIN AND VEGFRS, INTEGRINS IN REGULATING ENDOTHELIAL CELL FUNCTIONS.

Degree: 2015, University of Kentucky

URL: https://uknowledge.uky.edu/biochem_etds/23

► The neuropilin (Nrp) family consists of multifunctional cell surface receptors with critical roles in a number of different cell and tissue types. A core aspect… (more)

▼ The neuropilin (Nrp) family consists of multifunctional cell surface receptors with critical roles in a number of different cell and tissue types. A core aspect of Nrp function is ligand-dependent cellular adhesion and migration, where it controls the multistep process of cellular motility through integration of ligand binding, receptor coupling and signaling via the coordinated action of its extracellular and intracellular domains. While Nrp regulates cellular adhesion and motility in the cardiovascular and nervous systems under physiological conditions, the emerging pathological role of Nrp in tumor cell migration and metastasis has been identified and provides motivation for continued efforts toward developing Nrp inhibitors. At the molecular level, the role of Nrp in adhesion and migration is intimately connected to the control of adhesive interactions and cytoskeletal reorganization. The adhesive “interactome” for Nrp draws much attention because of its lack of enzymatic activity and inability to transduce signals on its own. It is an active area of research and is still expanding dramatically. Nrp has been well defined as a co-receptor for vascular endothelial growth factor receptor (VEGFR)/vascular endothelial growth factor (VEGF) signaling through enhancing receptor-ligand interaction in angiogenesis. Here, we contribute to this concept through characterization in more biochemical detail about Nrp-1/VEGF physical interactions. VEGF has been shown to compete with Sema3 for binding to Nrp-1 b1 ligand binding pocket. This competition fine-tunes VEGF-induced angiogenesis. Our data provides a molecular mechanism for high affinity Sema3F binding to Nrp-1 in the b1 domain. As to the VEGFR-independent function, Nrp/integrin association has been demonstrated. The functional integration has been shown for Nrp/integrin in angiogenic sprouting. Both proteins are highly expressed in endothelial tip cells to mediate endothelial cell migration during angiogenesis and knockdown of either one in mice leads to embryonic lethality due to similar defects in vascular development. To identify the structure and function correlation, we characterized in more detail about Nrp-1/integrin physical interactions with biochemical and cell-based assays. Through an integrated approach of biochemical, molecular and cellular methods, we defined the direct physical interactions between Nrp-1 and integrins. We have also extended this work to demonstrate the functional importance and contribution of the interactions in integrin-mediated cell adhesion on extracellular matrix (ECM) in angiogenesis and platelet function during wound healing and provide a molecular basis for the integration of Nrps/integrins in cell migration, adhesion to ECM, breast cancer initiation and breast cancer stem cell fate determination.

Subjects/Keywords: Neuropilin 1; Vascular Endothelial Growth Factor Receptor; Vascular Endothelial Growth Factor; Integrin and Extracellular Matrix; Biochemistry; Molecular Biology; Structural Biology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Li, X. (2015). PHYSICAL INTERACTIONS BETWEEN NEUROPILIN AND VEGFRS, INTEGRINS IN REGULATING ENDOTHELIAL CELL FUNCTIONS. (Doctoral Dissertation). University of Kentucky. Retrieved from https://uknowledge.uky.edu/biochem_etds/23

Chicago Manual of Style (16^th Edition):

Li, Xiaobo. “PHYSICAL INTERACTIONS BETWEEN NEUROPILIN AND VEGFRS, INTEGRINS IN REGULATING ENDOTHELIAL CELL FUNCTIONS.” 2015. Doctoral Dissertation, University of Kentucky. Accessed February 28, 2021. https://uknowledge.uky.edu/biochem_etds/23.

MLA Handbook (7^th Edition):

Li, Xiaobo. “PHYSICAL INTERACTIONS BETWEEN NEUROPILIN AND VEGFRS, INTEGRINS IN REGULATING ENDOTHELIAL CELL FUNCTIONS.” 2015. Web. 28 Feb 2021.

Vancouver:

Li X. PHYSICAL INTERACTIONS BETWEEN NEUROPILIN AND VEGFRS, INTEGRINS IN REGULATING ENDOTHELIAL CELL FUNCTIONS. [Internet] [Doctoral dissertation]. University of Kentucky; 2015. [cited 2021 Feb 28]. Available from: https://uknowledge.uky.edu/biochem_etds/23.

Council of Science Editors:

Li X. PHYSICAL INTERACTIONS BETWEEN NEUROPILIN AND VEGFRS, INTEGRINS IN REGULATING ENDOTHELIAL CELL FUNCTIONS. [Doctoral Dissertation]. University of Kentucky; 2015. Available from: https://uknowledge.uky.edu/biochem_etds/23

25. Zamani, Ali. Serotonin signaling in angiogenesis.

Degree: PhD, 2012, University of Alabama – Birmingham

URL: http://contentdm.mhsl.uab.edu/u?/etd,1383

►

Serotonin (5-hydroxytryptamine, 5-HT) is a well-known "happy" neurotransmitter. Selective serotonin reuptake inhibitors (SSRIs) are the most prescribed class of antidepressant medications to raise the serotonin… (more)

▼

Serotonin (5-hydroxytryptamine, 5-HT) is a well-known "happy" neurotransmitter. Selective serotonin reuptake inhibitors (SSRIs) are the most prescribed class of antidepressant medications to raise the serotonin level in the brain. However, the majority of serotonin in the human body is present outside of the brain and stored in platelets in blood circulation. Blood coagulation is a common feature of malignant solid tumors and leads to significant serotonin release from activated platelets into tumor environment. Due to the unique feature of platelet in lacking nucleus, the impact of platelet and serotonin on cancer progression has been overlooked by studies focusing on cancer genomic profiling. This research with in vitro and in vivo approaches has demonstrated serotonin angiogenesis promoting activities. Serotonin receptor 1B (HTR1B) has been identified for its high expression level in human endothelial cells and its role in mediating serotonin induced angiogenic signaling. Serotonin and the known angiogenic factor, vascular endothelial growth factor (VEGF) stimulate a same set of downstream signaling kinases, highlighting the overlapping angiogenic signalings activated by different angiogenic factors in tumor environment. These results suggest a potential mechanism underlying the resistance to the current VEGF-targeting anti-angiogenic therapy against cancer. Selective antagonists of HTR1B have demonstrated in vitro anti-angiogenic activities and inhibition of tumor angiogenesis in an ex vivo tumor angiogenesis model system. Systemic treatment of tumor-bearing mice with HTR1B antagonists has resulted in a significant inhibition against tumor growth and tumor microvessel density in a xenograft mouse model of human ovarian cancer. This study provides evidence that, under physiologically relevant conditions of tumor environment, serotonin functions as a potent angiokine with a higher angiogenic potential than that of VEGF and reveals a new molecular mechanism of tumor angiogenesis. This research has identified HTR1B and its downstream angiogenicsignaling pathway as novel targets for development of new cancer therapy. In addition, to understand the correlation between the antidepressants use and cancer risks as a critical public health issue, this study suggests a future investigation on possible effects of SSRIs in tumor angiogenesis through regulating serotonin levels in tumor environment and around dormant tumor.

1 online resource (xiv, 127 p.) :ill., digital, PDF file.

Pharmacology And Toxicology

Joint Health Sciences

Serotonin, HTR1B, GPCR, Angiogenesis, Platelet, Cancer

UNRESTRICTED

Advisors/Committee Members: Mahmoud El Kouni, Additional advisors: Mary-Ann Bjornsti, Xu Feng, Andra Frost, Zhican Qu..

Subjects/Keywords: Angiogenesis Inducing Agents – pharmacology <; br>; Blood Platelets<; br>; HTR1B protein, human<; br>; Neoplasms<; br>; Serotonin<; br>; Vascular Endothelial Growth Factors

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zamani, A. (2012). Serotonin signaling in angiogenesis. (Doctoral Dissertation). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,1383

Chicago Manual of Style (16^th Edition):

Zamani, Ali. “Serotonin signaling in angiogenesis.” 2012. Doctoral Dissertation, University of Alabama – Birmingham. Accessed February 28, 2021. http://contentdm.mhsl.uab.edu/u?/etd,1383.

MLA Handbook (7^th Edition):

Zamani, Ali. “Serotonin signaling in angiogenesis.” 2012. Web. 28 Feb 2021.

Vancouver:

Zamani A. Serotonin signaling in angiogenesis. [Internet] [Doctoral dissertation]. University of Alabama – Birmingham; 2012. [cited 2021 Feb 28]. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1383.

Council of Science Editors:

Zamani A. Serotonin signaling in angiogenesis. [Doctoral Dissertation]. University of Alabama – Birmingham; 2012. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1383

University of Hong Kong

26. 虞曉敏. Characterization of VEGF-C and its clinical relevance in lymphangiogenesis of papillary thyroid carcinoma.

Degree: 2007, University of Hong Kong

URL: http://hdl.handle.net/10722/52763

Subjects/Keywords: Lymphatics - Cancer.; Vascular endothelial growth factors.; Lymphatic metastasis.; Thyroid gland - Cancer.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

虞曉敏. (2007). Characterization of VEGF-C and its clinical relevance in lymphangiogenesis of papillary thyroid carcinoma. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/52763

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

虞曉敏. “Characterization of VEGF-C and its clinical relevance in lymphangiogenesis of papillary thyroid carcinoma.” 2007. Thesis, University of Hong Kong. Accessed February 28, 2021. http://hdl.handle.net/10722/52763.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

虞曉敏. “Characterization of VEGF-C and its clinical relevance in lymphangiogenesis of papillary thyroid carcinoma.” 2007. Web. 28 Feb 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

虞曉敏. Characterization of VEGF-C and its clinical relevance in lymphangiogenesis of papillary thyroid carcinoma. [Internet] [Thesis]. University of Hong Kong; 2007. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10722/52763.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

虞曉敏. Characterization of VEGF-C and its clinical relevance in lymphangiogenesis of papillary thyroid carcinoma. [Thesis]. University of Hong Kong; 2007. Available from: http://hdl.handle.net/10722/52763

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Vanderbilt University

27. DeBusk, Laura M. AKT/IKKα/VAV1 signaling in endothelial cell survival and angiogenesis.

Degree: PhD, Cancer Biology, 2008, Vanderbilt University

URL: http://hdl.handle.net/1803/11831

► We have identified a novel signaling pathway, AKT/IKKα/VAV1, which induces endothelial cell survival and motility. Ang1/Tie2 and VEGF/VEGFR signaling activates Akt and induces cell survival.… (more)

Subjects/Keywords: angiogenesis; Neovascularization – Regulation; Vascular endothelial growth factors – Pathophysiology; Cellular control mechanisms

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

DeBusk, L. M. (2008). AKT/IKKα/VAV1 signaling in endothelial cell survival and angiogenesis. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/11831

Chicago Manual of Style (16^th Edition):

DeBusk, Laura M. “AKT/IKKα/VAV1 signaling in endothelial cell survival and angiogenesis.” 2008. Doctoral Dissertation, Vanderbilt University. Accessed February 28, 2021. http://hdl.handle.net/1803/11831.

MLA Handbook (7^th Edition):

DeBusk, Laura M. “AKT/IKKα/VAV1 signaling in endothelial cell survival and angiogenesis.” 2008. Web. 28 Feb 2021.

Vancouver:

DeBusk LM. AKT/IKKα/VAV1 signaling in endothelial cell survival and angiogenesis. [Internet] [Doctoral dissertation]. Vanderbilt University; 2008. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1803/11831.

Council of Science Editors:

DeBusk LM. AKT/IKKα/VAV1 signaling in endothelial cell survival and angiogenesis. [Doctoral Dissertation]. Vanderbilt University; 2008. Available from: http://hdl.handle.net/1803/11831

Washington State University

28. [No author]. Ethanol affects vascular endothelial growth factor and its receptors in coronary microvascular endothelial cells .

Degree: 2004, Washington State University

URL: http://hdl.handle.net/2376/178

Subjects/Keywords: Vascular endothelial growth factors.; Alcohol – Physiological effect.; Cardiovascular system – Diseases.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

author], [. (2004). Ethanol affects vascular endothelial growth factor and its receptors in coronary microvascular endothelial cells . (Thesis). Washington State University. Retrieved from http://hdl.handle.net/2376/178

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

author], [No. “Ethanol affects vascular endothelial growth factor and its receptors in coronary microvascular endothelial cells .” 2004. Thesis, Washington State University. Accessed February 28, 2021. http://hdl.handle.net/2376/178.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

author], [No. “Ethanol affects vascular endothelial growth factor and its receptors in coronary microvascular endothelial cells .” 2004. Web. 28 Feb 2021.

Vancouver:

author] [. Ethanol affects vascular endothelial growth factor and its receptors in coronary microvascular endothelial cells . [Internet] [Thesis]. Washington State University; 2004. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/2376/178.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

author] [. Ethanol affects vascular endothelial growth factor and its receptors in coronary microvascular endothelial cells . [Thesis]. Washington State University; 2004. Available from: http://hdl.handle.net/2376/178

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

29. Sedin, Engla Maria Helena. Semi-automated immunohistochemical staining of the VEGF-A-protein for clinical use and the identification in NHG-graded breast carcinoma.

Degree: Women's and Children's Health, 2014, Uppsala University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-237106

► Angiogenesis has a crucial influence on tumour development and identification of microvessels in malignant breast cancer tissue is an indicator for worse prognosis. Angiogenesis… (more)

Subjects/Keywords: CD31; grade; immunohistochemistry; invasive breast cancer; vascular endothelial growth factors

…Yancopoulos GD, Davis S, Gale NW, et al., Vascular-specific growth factors and blood vessel… …al., Vascular endothelial growth factor (VEGF) and its receptors, FASEB J, 1999… …vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon… …Extracellular cleavage of the vascular endothelial growth factor 189-amino acid form by urokinase is… …Activation of Vascular Endothelial Growth Factor Gene Transcription by Hypoxia-Inducible Factor 1…

4 more images…

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APA (6^th Edition):

Sedin, E. M. H. (2014). Semi-automated immunohistochemical staining of the VEGF-A-protein for clinical use and the identification in NHG-graded breast carcinoma. (Thesis). Uppsala University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-237106

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sedin, Engla Maria Helena. “Semi-automated immunohistochemical staining of the VEGF-A-protein for clinical use and the identification in NHG-graded breast carcinoma.” 2014. Thesis, Uppsala University. Accessed February 28, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-237106.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sedin, Engla Maria Helena. “Semi-automated immunohistochemical staining of the VEGF-A-protein for clinical use and the identification in NHG-graded breast carcinoma.” 2014. Web. 28 Feb 2021.

Vancouver:

Sedin EMH. Semi-automated immunohistochemical staining of the VEGF-A-protein for clinical use and the identification in NHG-graded breast carcinoma. [Internet] [Thesis]. Uppsala University; 2014. [cited 2021 Feb 28]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-237106.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sedin EMH. Semi-automated immunohistochemical staining of the VEGF-A-protein for clinical use and the identification in NHG-graded breast carcinoma. [Thesis]. Uppsala University; 2014. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-237106

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Florida Atlantic University

30. Bancalari-Schmidlapp, Angela. Vascular endothelial growth factor (VEGF), BCL-2, and BAX expression in fibropapilloma tumor tissue and skin tissue of sea turtles.

Degree: MS, 2009, Florida Atlantic University

URL: http://purl.flvc.org/FAU/209981

►

Summary: In sea turtles, the study of the etiology and development of fibropapillomatosis is not fully understood. Sea turtle fibropapillomatosis is a disease characterized by… (more)

Subjects/Keywords: Sea turtles – Physiology; Cancer – Pathophysiology; Vascular endothelial growth factors – Pathophysiology; Cellular signal transduction

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bancalari-Schmidlapp, A. (2009). Vascular endothelial growth factor (VEGF), BCL-2, and BAX expression in fibropapilloma tumor tissue and skin tissue of sea turtles. (Masters Thesis). Florida Atlantic University. Retrieved from http://purl.flvc.org/FAU/209981

Chicago Manual of Style (16^th Edition):

Bancalari-Schmidlapp, Angela. “Vascular endothelial growth factor (VEGF), BCL-2, and BAX expression in fibropapilloma tumor tissue and skin tissue of sea turtles.” 2009. Masters Thesis, Florida Atlantic University. Accessed February 28, 2021. http://purl.flvc.org/FAU/209981.

MLA Handbook (7^th Edition):

Bancalari-Schmidlapp, Angela. “Vascular endothelial growth factor (VEGF), BCL-2, and BAX expression in fibropapilloma tumor tissue and skin tissue of sea turtles.” 2009. Web. 28 Feb 2021.

Vancouver:

Bancalari-Schmidlapp A. Vascular endothelial growth factor (VEGF), BCL-2, and BAX expression in fibropapilloma tumor tissue and skin tissue of sea turtles. [Internet] [Masters thesis]. Florida Atlantic University; 2009. [cited 2021 Feb 28]. Available from: http://purl.flvc.org/FAU/209981.

Council of Science Editors:

Bancalari-Schmidlapp A. Vascular endothelial growth factor (VEGF), BCL-2, and BAX expression in fibropapilloma tumor tissue and skin tissue of sea turtles. [Masters Thesis]. Florida Atlantic University; 2009. Available from: http://purl.flvc.org/FAU/209981

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